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|---|---|---|---|---|---|---|
split_0_train_28300
|
split_0_train_28300
|
[
{
"id": "split_0_train_28300_passage",
"type": "progene_text",
"text": [
"A variety of severe illnesses can induce changes in thyroid hormone metabolism , leading to findings referred to as \" sick euthyroid syndrome \" ( ESS ) ."
],
"offsets": [
[
0,
153
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28301
|
split_0_train_28301
|
[
{
"id": "split_0_train_28301_passage",
"type": "progene_text",
"text": [
"These thyroid hormone changes may be mediated in part by cytokines or other inflammatory mediators , acting at the level of the hypothalamus and pituitary gland , the thyroid gland , and the hepatic deiodinase system ."
],
"offsets": [
[
0,
218
]
]
}
] |
[
{
"id": "split_0_train_45844_entity",
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"text": [
"cytokines"
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57,
66
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{
"id": "split_0_train_45845_entity",
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"text": [
"deiodinase"
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[
199,
209
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28302
|
split_0_train_28302
|
[
{
"id": "split_0_train_28302_passage",
"type": "progene_text",
"text": [
"The degree of thyroid function disturbance correlates with disease severity and low levels of thyroid hormones predict a poor prognosis in several illnesses ."
],
"offsets": [
[
0,
158
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28303
|
split_0_train_28303
|
[
{
"id": "split_0_train_28303_passage",
"type": "progene_text",
"text": [
"It remains unresolved whether the hormone responses in the ESS represent part of an adaptative response , which lowers tissue energy requirements in the face of systemic illness , or a maladaptive response , which induces damaging tissue hypothyroidism ."
],
"offsets": [
[
0,
254
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28304
|
split_0_train_28304
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[
{
"id": "split_0_train_28304_passage",
"type": "progene_text",
"text": [
"METHODS :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28305
|
split_0_train_28305
|
[
{
"id": "split_0_train_28305_passage",
"type": "progene_text",
"text": [
"This study examines the incidence of ESS among 220 elderly subjects hospitalized with cancer ."
],
"offsets": [
[
0,
94
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28306
|
split_0_train_28306
|
[
{
"id": "split_0_train_28306_passage",
"type": "progene_text",
"text": [
"In each subjects some individual variables were studied : age , sex , type of cancer , presence of metastasis , rapid shortage of corporeal weight , general clinic condition ."
],
"offsets": [
[
0,
175
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28307
|
split_0_train_28307
|
[
{
"id": "split_0_train_28307_passage",
"type": "progene_text",
"text": [
"The following laboratory parameters were studied : serum glucose , sodium , potassium , calcium , cholesterol , lipids , proteins , leukocytes , serum , lipids haemoglobin , plateletes , VES and the end free triiodothyronine , free tiroxine and thyrotropin ."
],
"offsets": [
[
0,
258
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]
}
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{
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160,
171
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"type": "progene_text",
"text": [
"thyrotropin"
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"offsets": [
[
245,
256
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28308
|
split_0_train_28308
|
[
{
"id": "split_0_train_28308_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28309
|
split_0_train_28309
|
[
{
"id": "split_0_train_28309_passage",
"type": "progene_text",
"text": [
"The research points out that ESS is more frequent in the elderly subjects with cancer ( incidence 58 % ) ."
],
"offsets": [
[
0,
106
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28310
|
split_0_train_28310
|
[
{
"id": "split_0_train_28310_passage",
"type": "progene_text",
"text": [
"ESS type 1 , with FT3 low and FT4 and TSH normal , is the most frequent form ."
],
"offsets": [
[
0,
78
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]
}
] |
[
{
"id": "split_0_train_45848_entity",
"type": "progene_text",
"text": [
"TSH"
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"offsets": [
[
38,
41
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28311
|
split_0_train_28311
|
[
{
"id": "split_0_train_28311_passage",
"type": "progene_text",
"text": [
"The incidence of ESS is higher in elderly subjects with cancer , with recent and marked lose of corporeal weight ( incidence 86 % ) and in subjects with worst clinical conditions ."
],
"offsets": [
[
0,
180
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28312
|
split_0_train_28312
|
[
{
"id": "split_0_train_28312_passage",
"type": "progene_text",
"text": [
"Finally , a significant direct correlation between FT3 / serum cholesterol , FT3 / serum proteins , FT3 / serum sodium , FT3 / FT4 is observed ."
],
"offsets": [
[
0,
144
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28313
|
split_0_train_28313
|
[
{
"id": "split_0_train_28313_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28314
|
split_0_train_28314
|
[
{
"id": "split_0_train_28314_passage",
"type": "progene_text",
"text": [
"The results obtained point out the not yet solved problem of hormone replacement therapy in elderly patients with cancer in bad clinical conditions ."
],
"offsets": [
[
0,
149
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28315
|
split_0_train_28315
|
[
{
"id": "split_0_train_28315_passage",
"type": "progene_text",
"text": [
"Caenorhabditis elegans has scores of hedgehog - related genes : sequence and expression analysis ."
],
"offsets": [
[
0,
98
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]
}
] |
[
{
"id": "split_0_train_45849_entity",
"type": "progene_text",
"text": [
"hedgehog"
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"offsets": [
[
37,
45
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28316
|
split_0_train_28316
|
[
{
"id": "split_0_train_28316_passage",
"type": "progene_text",
"text": [
"Previously , we have described novel families of genes , warthog ( wrt ) and groundhog ( grd ) , in Caenorhabditis elegans ."
],
"offsets": [
[
0,
124
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]
}
] |
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{
"id": "split_0_train_45850_entity",
"type": "progene_text",
"text": [
"warthog"
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57,
64
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"normalized": []
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{
"id": "split_0_train_45851_entity",
"type": "progene_text",
"text": [
"wrt"
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67,
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{
"id": "split_0_train_45852_entity",
"type": "progene_text",
"text": [
"groundhog"
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{
"id": "split_0_train_45853_entity",
"type": "progene_text",
"text": [
"grd"
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"offsets": [
[
89,
92
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28317
|
split_0_train_28317
|
[
{
"id": "split_0_train_28317_passage",
"type": "progene_text",
"text": [
"They are related to Hedgehog ( Hh ) through the carboxy - terminal autoprocessing domain ( called Hog or Hint ) ."
],
"offsets": [
[
0,
113
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]
}
] |
[
{
"id": "split_0_train_45854_entity",
"type": "progene_text",
"text": [
"Hedgehog"
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20,
28
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{
"id": "split_0_train_45855_entity",
"type": "progene_text",
"text": [
"Hh"
],
"offsets": [
[
31,
33
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28318
|
split_0_train_28318
|
[
{
"id": "split_0_train_28318_passage",
"type": "progene_text",
"text": [
"A comprehensive survey revealed 10 genes with Hog / Hint modules in C. elegans ."
],
"offsets": [
[
0,
80
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28319
|
split_0_train_28319
|
[
{
"id": "split_0_train_28319_passage",
"type": "progene_text",
"text": [
"Five of these are associated with a Wart domain in wrt genes , and three with multiple copies of the Ground domain in grd genes ."
],
"offsets": [
[
0,
129
]
]
}
] |
[
{
"id": "split_0_train_45856_entity",
"type": "progene_text",
"text": [
"wrt"
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"offsets": [
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51,
54
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{
"id": "split_0_train_45857_entity",
"type": "progene_text",
"text": [
"grd"
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"offsets": [
[
118,
121
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28320
|
split_0_train_28320
|
[
{
"id": "split_0_train_28320_passage",
"type": "progene_text",
"text": [
"Both the Wart domain and the Ground domain occur also in genes encoding no Hog domain ."
],
"offsets": [
[
0,
87
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28321
|
split_0_train_28321
|
[
{
"id": "split_0_train_28321_passage",
"type": "progene_text",
"text": [
"Further , we define a new group of genes related to the grd genes , called ground - like ( grl ) ."
],
"offsets": [
[
0,
98
]
]
}
] |
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{
"id": "split_0_train_45858_entity",
"type": "progene_text",
"text": [
"grd"
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56,
59
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"normalized": []
},
{
"id": "split_0_train_45859_entity",
"type": "progene_text",
"text": [
"ground - like"
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"offsets": [
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75,
88
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"normalized": []
},
{
"id": "split_0_train_45860_entity",
"type": "progene_text",
"text": [
"grl"
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"offsets": [
[
91,
94
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28322
|
split_0_train_28322
|
[
{
"id": "split_0_train_28322_passage",
"type": "progene_text",
"text": [
"Overall , C. elegans has more than 50 genes belonging to these gene families ."
],
"offsets": [
[
0,
78
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28323
|
split_0_train_28323
|
[
{
"id": "split_0_train_28323_passage",
"type": "progene_text",
"text": [
"Phylogenetic and sequence analysis shows that the wrt , grd , and grl genes are derived from each other ."
],
"offsets": [
[
0,
105
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]
}
] |
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{
"id": "split_0_train_45861_entity",
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"text": [
"wrt"
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50,
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{
"id": "split_0_train_45862_entity",
"type": "progene_text",
"text": [
"grd"
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56,
59
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{
"id": "split_0_train_45863_entity",
"type": "progene_text",
"text": [
"grl"
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"offsets": [
[
66,
69
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28324
|
split_0_train_28324
|
[
{
"id": "split_0_train_28324_passage",
"type": "progene_text",
"text": [
"Further examination reveals a sequence motif with similarity to the core of the amino - terminal - signaling domain of Hh proteins ."
],
"offsets": [
[
0,
132
]
]
}
] |
[
{
"id": "split_0_train_45864_entity",
"type": "progene_text",
"text": [
"Hh"
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"offsets": [
[
119,
121
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28325
|
split_0_train_28325
|
[
{
"id": "split_0_train_28325_passage",
"type": "progene_text",
"text": [
"Our data suggest that the wrt , grd , grl , and hh genes are derived from a single ancestral gene ."
],
"offsets": [
[
0,
99
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]
}
] |
[
{
"id": "split_0_train_45865_entity",
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"wrt"
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26,
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{
"id": "split_0_train_45866_entity",
"type": "progene_text",
"text": [
"grd"
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32,
35
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{
"id": "split_0_train_45867_entity",
"type": "progene_text",
"text": [
"grl"
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38,
41
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"normalized": []
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{
"id": "split_0_train_45868_entity",
"type": "progene_text",
"text": [
"hh"
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"offsets": [
[
48,
50
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28326
|
split_0_train_28326
|
[
{
"id": "split_0_train_28326_passage",
"type": "progene_text",
"text": [
"wrt , grd , and grl genes are also present in other nematodes , but so far not in any other phyla ."
],
"offsets": [
[
0,
99
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]
}
] |
[
{
"id": "split_0_train_45869_entity",
"type": "progene_text",
"text": [
"wrt"
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3
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{
"id": "split_0_train_45870_entity",
"type": "progene_text",
"text": [
"grd"
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6,
9
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{
"id": "split_0_train_45871_entity",
"type": "progene_text",
"text": [
"grl"
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"offsets": [
[
16,
19
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28327
|
split_0_train_28327
|
[
{
"id": "split_0_train_28327_passage",
"type": "progene_text",
"text": [
"Conversely , hh is not found presently in C. elegans nor other nematodes ."
],
"offsets": [
[
0,
74
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]
}
] |
[
{
"id": "split_0_train_45872_entity",
"type": "progene_text",
"text": [
"hh"
],
"offsets": [
[
13,
15
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28328
|
split_0_train_28328
|
[
{
"id": "split_0_train_28328_passage",
"type": "progene_text",
"text": [
"Thus , the nematode genes could be the homologs of Hh molecules in other phyla ."
],
"offsets": [
[
0,
80
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]
}
] |
[
{
"id": "split_0_train_45873_entity",
"type": "progene_text",
"text": [
"Hh"
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"offsets": [
[
51,
53
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28329
|
split_0_train_28329
|
[
{
"id": "split_0_train_28329_passage",
"type": "progene_text",
"text": [
"The membrane molecule Patched has been shown previously to be a receptor of Hh ."
],
"offsets": [
[
0,
80
]
]
}
] |
[
{
"id": "split_0_train_45874_entity",
"type": "progene_text",
"text": [
"Patched"
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22,
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{
"id": "split_0_train_45875_entity",
"type": "progene_text",
"text": [
"Hh"
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"offsets": [
[
76,
78
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28330
|
split_0_train_28330
|
[
{
"id": "split_0_train_28330_passage",
"type": "progene_text",
"text": [
"Many Patched - related proteins are present in C. elegans , which may be targets of the hh - related genes ."
],
"offsets": [
[
0,
108
]
]
}
] |
[
{
"id": "split_0_train_45876_entity",
"type": "progene_text",
"text": [
"Patched"
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"offsets": [
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5,
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"normalized": []
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{
"id": "split_0_train_45877_entity",
"type": "progene_text",
"text": [
"hh"
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"offsets": [
[
88,
90
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28331
|
split_0_train_28331
|
[
{
"id": "split_0_train_28331_passage",
"type": "progene_text",
"text": [
"No Hedgehog - interacting protein ( Hip ) was found ."
],
"offsets": [
[
0,
53
]
]
}
] |
[
{
"id": "split_0_train_45878_entity",
"type": "progene_text",
"text": [
"Hedgehog - interacting protein"
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[
3,
33
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{
"id": "split_0_train_45879_entity",
"type": "progene_text",
"text": [
"Hip"
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"offsets": [
[
36,
39
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28332
|
split_0_train_28332
|
[
{
"id": "split_0_train_28332_passage",
"type": "progene_text",
"text": [
"We analyzed the expression patterns of eight wrt and eight grd genes ."
],
"offsets": [
[
0,
70
]
]
}
] |
[
{
"id": "split_0_train_45880_entity",
"type": "progene_text",
"text": [
"wrt"
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"offsets": [
[
45,
48
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{
"id": "split_0_train_45881_entity",
"type": "progene_text",
"text": [
"grd"
],
"offsets": [
[
59,
62
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28333
|
split_0_train_28333
|
[
{
"id": "split_0_train_28333_passage",
"type": "progene_text",
"text": [
"The results show that some closely related genes are expressed in the same tissues , but , overall , the expression patterns are diverse , comprising hypodermis , seam cells , the excretory cell , sheath and socket cells , and different types of neurons ."
],
"offsets": [
[
0,
255
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28334
|
split_0_train_28334
|
[
{
"id": "split_0_train_28334_passage",
"type": "progene_text",
"text": [
"Mutational analysis and NMR spectroscopy of quail cysteine and glycine - rich protein CRP2 reveal an intrinsic segmental flexibility of LIM domains ."
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"offsets": [
[
0,
149
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]
}
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{
"id": "split_0_train_45882_entity",
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136,
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}
] |
[] |
[] |
[] |
split_0_train_28335
|
split_0_train_28335
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[
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"type": "progene_text",
"text": [
"The LIM domain is a conserved cysteine and histidine - containing structural module of two tandemly arranged zinc fingers ."
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0,
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{
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"LIM"
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4,
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}
] |
[] |
[] |
[] |
split_0_train_28336
|
split_0_train_28336
|
[
{
"id": "split_0_train_28336_passage",
"type": "progene_text",
"text": [
"It has been identified in single or multiple copies in a variety of regulatory proteins , either in combination with defined functional domains , like homeodomains , or alone , like in the CRP family of LIM proteins ."
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0,
217
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}
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{
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203,
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] |
[] |
[] |
[] |
split_0_train_28337
|
split_0_train_28337
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[
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"type": "progene_text",
"text": [
"Structural studies of CRP proteins have allowed a detailed evaluation of interactions in LIM - domains at the molecular level ."
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0,
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{
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"LIM"
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89,
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] |
[] |
[] |
[] |
split_0_train_28338
|
split_0_train_28338
|
[
{
"id": "split_0_train_28338_passage",
"type": "progene_text",
"text": [
"The packing interactions in the hydrophobic core have been identified as a significant contribution to the LIM domain fold , whereas hydrogen bonding within each single zinc binding site stabilizes zinc finger geometry in a so - called \" outer \" or \" indirect \" coordination sphere ."
],
"offsets": [
[
0,
283
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}
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[
{
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"text": [
"LIM"
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[
107,
110
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}
] |
[] |
[] |
[] |
split_0_train_28339
|
split_0_train_28339
|
[
{
"id": "split_0_train_28339_passage",
"type": "progene_text",
"text": [
"Here we report the solution structure of a point - mutant of the carboxyl - terminal LIM domain of quail cysteine and glycine - rich protein CRP2 , CRP2 ( LIM2 ) R122A , and discuss the structural consequences of the disruption of the hydrogen bond formed between the guanidinium side - chain of Arg122 and the zinc - coordinating cysteine thiolate group in the CCHC rubredoxin - knuckle ."
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0,
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{
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{
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"type": "progene_text",
"text": [
"rubredoxin"
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[
367,
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}
] |
[] |
[] |
[] |
split_0_train_28340
|
split_0_train_28340
|
[
{
"id": "split_0_train_28340_passage",
"type": "progene_text",
"text": [
"The structural analysis revealed that the three - dimensional structure of the CCHC zinc binding site in CRP2 ( LIM2 ) R122A is adapted as a consequence of the modified hydrogen bonding pattern ."
],
"offsets": [
[
0,
195
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]
}
] |
[
{
"id": "split_0_train_45897_entity",
"type": "progene_text",
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105,
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{
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"type": "progene_text",
"text": [
"LIM2"
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[
112,
116
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28341
|
split_0_train_28341
|
[
{
"id": "split_0_train_28341_passage",
"type": "progene_text",
"text": [
"Additionally , as a result of the conformational rearrangement of the zinc binding site , the packing interactions in the hydrophobic core region are altered , leading to a change in the relative orientation of the two zinc fingers with a concomitant change in the solvent accessibilities of hydrophobic residues located at the interface of the two modules ."
],
"offsets": [
[
0,
358
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28342
|
split_0_train_28342
|
[
{
"id": "split_0_train_28342_passage",
"type": "progene_text",
"text": [
"The backbone dynamics of residues located in the folded part of CRP2 ( LIM2 ) R122A have been characterized by proton-detected(15)N NMR spectroscopy ."
],
"offsets": [
[
0,
150
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]
}
] |
[
{
"id": "split_0_train_45899_entity",
"type": "progene_text",
"text": [
"CRP2"
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64,
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{
"id": "split_0_train_45900_entity",
"type": "progene_text",
"text": [
"LIM2"
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"offsets": [
[
71,
75
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28343
|
split_0_train_28343
|
[
{
"id": "split_0_train_28343_passage",
"type": "progene_text",
"text": [
"Analysis of the R2 / R1ratios revealed a rotational correlation time of approximately 6.2 ns and tumbling with an axially symmetric diffusion tensor ( D parallel / D perpendicular = 1.43 ) ."
],
"offsets": [
[
0,
190
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28344
|
split_0_train_28344
|
[
{
"id": "split_0_train_28344_passage",
"type": "progene_text",
"text": [
"The relaxation data were also analyzed using a reduced spectral density mapping approach ."
],
"offsets": [
[
0,
90
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28345
|
split_0_train_28345
|
[
{
"id": "split_0_train_28345_passage",
"type": "progene_text",
"text": [
"As in wild - type CRP2 ( LIM2 ) , significant mobility on a picosecond / nanosecond time - scale was detected , and conformational exchange on a microsecond time - scale was identified for residues located in loop regions between secondary structure elements ."
],
"offsets": [
[
0,
260
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]
}
] |
[
{
"id": "split_0_train_45901_entity",
"type": "progene_text",
"text": [
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18,
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{
"id": "split_0_train_45902_entity",
"type": "progene_text",
"text": [
"LIM2"
],
"offsets": [
[
25,
29
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28346
|
split_0_train_28346
|
[
{
"id": "split_0_train_28346_passage",
"type": "progene_text",
"text": [
"In summary , the relative orientation of the two zinc binding sites and the accessibility of hydrophobic residues is not only determined by hydrophobic interactions , but can also be modified by the formation and/or breakage of hydrogen bonds ."
],
"offsets": [
[
0,
244
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28347
|
split_0_train_28347
|
[
{
"id": "split_0_train_28347_passage",
"type": "progene_text",
"text": [
"This may be important for the molecular interactions of an adaptor - type LIM domain protein in macromolecular complexes , particularly for the modulation of protein - protein interactions ."
],
"offsets": [
[
0,
190
]
]
}
] |
[
{
"id": "split_0_train_45903_entity",
"type": "progene_text",
"text": [
"LIM"
],
"offsets": [
[
74,
77
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28348
|
split_0_train_28348
|
[
{
"id": "split_0_train_28348_passage",
"type": "progene_text",
"text": [
"Cloning and partial characterization of the proteasome S4 ATPase from Plasmodium falciparum ."
],
"offsets": [
[
0,
93
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]
}
] |
[
{
"id": "split_0_train_45904_entity",
"type": "progene_text",
"text": [
"proteasome S4 ATPase"
],
"offsets": [
[
44,
64
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28349
|
split_0_train_28349
|
[
{
"id": "split_0_train_28349_passage",
"type": "progene_text",
"text": [
"Certad , G. , Abrahem , A. , and Georges , E. 1999 ."
],
"offsets": [
[
0,
52
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28350
|
split_0_train_28350
|
[
{
"id": "split_0_train_28350_passage",
"type": "progene_text",
"text": [
"Cloning and Partial characterization of the proteasome S4 ATPase from Plasmodium falciparum ."
],
"offsets": [
[
0,
93
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]
}
] |
[
{
"id": "split_0_train_45905_entity",
"type": "progene_text",
"text": [
"proteasome S4 ATPase"
],
"offsets": [
[
44,
64
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28351
|
split_0_train_28351
|
[
{
"id": "split_0_train_28351_passage",
"type": "progene_text",
"text": [
"Experimental Parasitology 93 , 123 - 131 ."
],
"offsets": [
[
0,
42
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28352
|
split_0_train_28352
|
[
{
"id": "split_0_train_28352_passage",
"type": "progene_text",
"text": [
"The ATP - ubiquitin - proteasome pathway mediates the nonlysosomal degradation of cytosolic proteins in eukaryotic cells ."
],
"offsets": [
[
0,
122
]
]
}
] |
[
{
"id": "split_0_train_45906_entity",
"type": "progene_text",
"text": [
"ubiquitin"
],
"offsets": [
[
10,
19
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28353
|
split_0_train_28353
|
[
{
"id": "split_0_train_28353_passage",
"type": "progene_text",
"text": [
"The activities of this pathway have been shown to regulate cell growth and differentiation through modulation of regulatory proteins ."
],
"offsets": [
[
0,
134
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28354
|
split_0_train_28354
|
[
{
"id": "split_0_train_28354_passage",
"type": "progene_text",
"text": [
"The proteasome is a large complex consisting of two multisubunit structures , the 20S and 19S ( PA700 ) or P28 complexes , that combine to form the 26S particles ."
],
"offsets": [
[
0,
163
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28355
|
split_0_train_28355
|
[
{
"id": "split_0_train_28355_passage",
"type": "progene_text",
"text": [
"In this study , we describe the cloning of a cDNA encoding the proteasome subunit 4 ATPase homologue from Plasmodium falciparum ( PFS4 ) ."
],
"offsets": [
[
0,
138
]
]
}
] |
[
{
"id": "split_0_train_45907_entity",
"type": "progene_text",
"text": [
"proteasome subunit 4 ATPase"
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"offsets": [
[
63,
90
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},
{
"id": "split_0_train_45908_entity",
"type": "progene_text",
"text": [
"PFS4"
],
"offsets": [
[
130,
134
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28356
|
split_0_train_28356
|
[
{
"id": "split_0_train_28356_passage",
"type": "progene_text",
"text": [
"Analysis of the PFS4 cDNA sequence shows an open reading frame encoding a deduced protein of 455 amino acids ."
],
"offsets": [
[
0,
110
]
]
}
] |
[
{
"id": "split_0_train_45909_entity",
"type": "progene_text",
"text": [
"PFS4"
],
"offsets": [
[
16,
20
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28357
|
split_0_train_28357
|
[
{
"id": "split_0_train_28357_passage",
"type": "progene_text",
"text": [
"Moreover , comparison of PFS4 cDNA sequence to that of genomic fragments encoding PFS4 showed identical sequences with no detectable introns ."
],
"offsets": [
[
0,
142
]
]
}
] |
[
{
"id": "split_0_train_45910_entity",
"type": "progene_text",
"text": [
"PFS4"
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"offsets": [
[
25,
29
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],
"normalized": []
},
{
"id": "split_0_train_45911_entity",
"type": "progene_text",
"text": [
"PFS4"
],
"offsets": [
[
82,
86
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28358
|
split_0_train_28358
|
[
{
"id": "split_0_train_28358_passage",
"type": "progene_text",
"text": [
"Database searches revealed a high sequence identity to those of rice , yeast , mouse , Drosophila , and human S4 ATPases ."
],
"offsets": [
[
0,
122
]
]
}
] |
[
{
"id": "split_0_train_45912_entity",
"type": "progene_text",
"text": [
"S4 ATPases"
],
"offsets": [
[
110,
120
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28359
|
split_0_train_28359
|
[
{
"id": "split_0_train_28359_passage",
"type": "progene_text",
"text": [
"However , PFS4 contains two unique inserts of nine and seven amino acid residues in the N - terminal domain ."
],
"offsets": [
[
0,
109
]
]
}
] |
[
{
"id": "split_0_train_45913_entity",
"type": "progene_text",
"text": [
"PFS4"
],
"offsets": [
[
10,
14
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28360
|
split_0_train_28360
|
[
{
"id": "split_0_train_28360_passage",
"type": "progene_text",
"text": [
"Interestingly , only the rice S4 contains the latter ( seven amino acids ) insert with four identical amino acids ."
],
"offsets": [
[
0,
115
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28361
|
split_0_train_28361
|
[
{
"id": "split_0_train_28361_passage",
"type": "progene_text",
"text": [
"In vitro expression of the full - length cDNA encoding the PFS4 , using a transcription - translation - coupled reticulocyte lysate , shows a 50 - kDa [(35)S]methionine - labeled protein which was immunoprecipitated with PFS4 anti - peptide antiserum ."
],
"offsets": [
[
0,
252
]
]
}
] |
[
{
"id": "split_0_train_45914_entity",
"type": "progene_text",
"text": [
"PFS4"
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"offsets": [
[
59,
63
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],
"normalized": []
},
{
"id": "split_0_train_45915_entity",
"type": "progene_text",
"text": [
"PFS4"
],
"offsets": [
[
221,
225
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28362
|
split_0_train_28362
|
[
{
"id": "split_0_train_28362_passage",
"type": "progene_text",
"text": [
"Southern blot analysis of genomic DNA digests shows a single gene copy of PFS4 in P. falciparum ."
],
"offsets": [
[
0,
97
]
]
}
] |
[
{
"id": "split_0_train_45916_entity",
"type": "progene_text",
"text": [
"PFS4"
],
"offsets": [
[
74,
78
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28363
|
split_0_train_28363
|
[
{
"id": "split_0_train_28363_passage",
"type": "progene_text",
"text": [
"Of interest was the effect of the proteasome - specific natural product , lactacystin , on the growth of the parasite , with IC(50) values of 0.6 - 0.92 microM ."
],
"offsets": [
[
0,
161
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28364
|
split_0_train_28364
|
[
{
"id": "split_0_train_28364_passage",
"type": "progene_text",
"text": [
"The latter IC(50) values of lactacystin for different clones of P. falciparum are comparable to those obtained for mammalian cell lines ( 0.65 microM ) , suggesting the presence of a conserved proteasome complex ."
],
"offsets": [
[
0,
213
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28365
|
split_0_train_28365
|
[
{
"id": "split_0_train_28365_passage",
"type": "progene_text",
"text": [
"Moreover , lactacystin was equally toxic to drug - sensitive and resistant parasites ."
],
"offsets": [
[
0,
86
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28366
|
split_0_train_28366
|
[
{
"id": "split_0_train_28366_passage",
"type": "progene_text",
"text": [
"Exact rebinning methods for three - dimensional PET ."
],
"offsets": [
[
0,
53
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28367
|
split_0_train_28367
|
[
{
"id": "split_0_train_28367_passage",
"type": "progene_text",
"text": [
"The high computational cost of data processing in volume PET imaging is still hindering the routine application of this successful technique , especially in the case of dynamic studies ."
],
"offsets": [
[
0,
186
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28368
|
split_0_train_28368
|
[
{
"id": "split_0_train_28368_passage",
"type": "progene_text",
"text": [
"This paper describes two new algorithms based on an exact rebinning equation , which can be applied to accelerate the processing of three - dimensional ( 3-D ) PET data ."
],
"offsets": [
[
0,
170
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28369
|
split_0_train_28369
|
[
{
"id": "split_0_train_28369_passage",
"type": "progene_text",
"text": [
"The first algorithm , FOREPROJ , is a fast - forward projection algorithm that allows calculation of the 3-D attenuation correction factors ( ACF 's ) directly from a two - dimensional ( 2-D ) transmission scan , without first reconstructing the attenuation map and then performing a 3-D forward projection ."
],
"offsets": [
[
0,
308
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28370
|
split_0_train_28370
|
[
{
"id": "split_0_train_28370_passage",
"type": "progene_text",
"text": [
"The use of FOREPROJ speeds up the estimation of the 3-D ACF 's by more than a factor five ."
],
"offsets": [
[
0,
91
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28371
|
split_0_train_28371
|
[
{
"id": "split_0_train_28371_passage",
"type": "progene_text",
"text": [
"The second algorithm , FOREX , is a rebinning algorithm that is also more than five times faster , compared to the standard reprojection algorithm ( 3DRP ) and does not suffer from the image distortions generated by the even faster approximate Fourier rebinning ( FORE ) method at large axial apertures ."
],
"offsets": [
[
0,
304
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28372
|
split_0_train_28372
|
[
{
"id": "split_0_train_28372_passage",
"type": "progene_text",
"text": [
"However , FOREX is probably not required by most existing scanners , as the axial apertures are not large enough to show improvements over FORE with clinical data ."
],
"offsets": [
[
0,
164
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28373
|
split_0_train_28373
|
[
{
"id": "split_0_train_28373_passage",
"type": "progene_text",
"text": [
"Both algorithms have been implemented and applied to data simulated for a scanner with a large axial aperture ( 30 degrees ) , and also to data acquired with the ECAT HR and the ECAT HR + scanners ."
],
"offsets": [
[
0,
198
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28374
|
split_0_train_28374
|
[
{
"id": "split_0_train_28374_passage",
"type": "progene_text",
"text": [
"Results demonstrate the excellent accuracy achieved by these algorithms and the important speedup when the sinogram sizes are powers of two ."
],
"offsets": [
[
0,
141
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28375
|
split_0_train_28375
|
[
{
"id": "split_0_train_28375_passage",
"type": "progene_text",
"text": [
"The role of pulmonary and systemic circulation in the tracheal blood supply in rats ."
],
"offsets": [
[
0,
85
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28376
|
split_0_train_28376
|
[
{
"id": "split_0_train_28376_passage",
"type": "progene_text",
"text": [
"The different roles of bronchial and pulmonary circulation in the tracheal blood supply were investigated in 26 female rats : a control group ( CG , n = 7 ) , a group with pulmonary hilar ligation ( PL , n = 5 ) , another with tracheal transsection ( TL , n = 9 ) and a group with both these procedures ( TL & PL , n = 5 ) ."
],
"offsets": [
[
0,
324
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28377
|
split_0_train_28377
|
[
{
"id": "split_0_train_28377_passage",
"type": "progene_text",
"text": [
"Technetium 99 - m was injected into the left ventricle postoperatively , and the radioactivity of tracheal samples was calculated as a percentage of injected activity / g tissue ( % ID / g ) ."
],
"offsets": [
[
0,
192
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28378
|
split_0_train_28378
|
[
{
"id": "split_0_train_28378_passage",
"type": "progene_text",
"text": [
"The tracheal uptake averaged 1.9 in group CG , and 1.7 , 1.3 and 1.5 % ID / g in groups PL , TL and TL&PL , respectively ."
],
"offsets": [
[
0,
122
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28379
|
split_0_train_28379
|
[
{
"id": "split_0_train_28379_passage",
"type": "progene_text",
"text": [
"Tracheal transsection ( TL ) thus reduced the tracheal blood supply by 29.7 % compared with the control group ( p < 0.05 ) , whereas the reduction of tracheal blood supply following pulmonary hilar ligation ( PL ) was only 10.9 % ( n.s. ) ."
],
"offsets": [
[
0,
240
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28380
|
split_0_train_28380
|
[
{
"id": "split_0_train_28380_passage",
"type": "progene_text",
"text": [
"Tracheal transsection combined with hilar ligation ( TL & PL ) effected a reduction of 19.9 % ( n.s. ) ."
],
"offsets": [
[
0,
104
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28381
|
split_0_train_28381
|
[
{
"id": "split_0_train_28381_passage",
"type": "progene_text",
"text": [
"We conclude that only 10.9 % of the tracheal blood supply comes from the pulmonary circulation ."
],
"offsets": [
[
0,
96
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28382
|
split_0_train_28382
|
[
{
"id": "split_0_train_28382_passage",
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"text": [
"Recombinant human aggrecan G1-G2 exhibits native binding properties and substrate specificity for matrix metalloproteinases and aggrecanase ."
],
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[
0,
141
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]
}
] |
[
{
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"text": [
"aggrecanase"
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"offsets": [
[
128,
139
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"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28383
|
split_0_train_28383
|
[
{
"id": "split_0_train_28383_passage",
"type": "progene_text",
"text": [
"A recombinant human aggrecan G1-G2 fragment comprising amino acids Val(1)-Arg(656) has been expressed in Sf21 cells using a baculovirus expression system ."
],
"offsets": [
[
0,
155
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]
}
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[
{
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"type": "progene_text",
"text": [
"aggrecan"
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"offsets": [
[
20,
28
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"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28384
|
split_0_train_28384
|
[
{
"id": "split_0_train_28384_passage",
"type": "progene_text",
"text": [
"The recombinant G1-G2 ( rG1-G2 ) was purified to homogeneity by hyaluronan - Sepharose affinity chromatography followed by high performance liquid chromatography gel filtration , and gave a single band of M(r) 90,000-95,000 by silver stain or immunoblotting with monoclonal antibody 1-C-6 ."
],
"offsets": [
[
0,
290
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28385
|
split_0_train_28385
|
[
{
"id": "split_0_train_28385_passage",
"type": "progene_text",
"text": [
"The expressed G1-G2 bound to both hyaluronan and link protein indicating that the immunoglobulin - fold motif and proteoglycan tandem repeat loops of the G1 domain were correctly folded ."
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[
0,
187
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}
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[
{
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"type": "progene_text",
"text": [
"immunoglobulin"
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[
82,
96
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}
] |
[] |
[] |
[] |
split_0_train_28386
|
split_0_train_28386
|
[
{
"id": "split_0_train_28386_passage",
"type": "progene_text",
"text": [
"Further analysis of secondary structure by rotary shadowing electron microscopy confirmed a double globe appearance , but revealed that the rG1-G2 was more compact than its native counterpart ."
],
"offsets": [
[
0,
193
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28387
|
split_0_train_28387
|
[
{
"id": "split_0_train_28387_passage",
"type": "progene_text",
"text": [
"The size of rG1-G2 by SDS-polyacrylamide gel electorphoresis was unchanged following digestion with keratanase and keratanase II and reduced by only 2-5 kDa following digestion with either O-glycosidase or N-glycosidase F ."
],
"offsets": [
[
0,
223
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]
}
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{
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"text": [
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100,
110
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{
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115,
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{
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189,
202
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{
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"text": [
"N-glycosidase F"
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"offsets": [
[
206,
221
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28388
|
split_0_train_28388
|
[
{
"id": "split_0_train_28388_passage",
"type": "progene_text",
"text": [
"Recombinant G1-G2 was digested with purified matrix metalloproteinases ( MMP ) , isolated aggrecanase , purified atrolysin C , or proteinases present in conditioned medium from cartilage explant cultures , and the products analyzed on SDS gels by silver stain and immunoblotting ."
],
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[
0,
280
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]
}
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{
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"text": [
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45,
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{
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73,
76
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{
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"text": [
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90,
101
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{
"id": "split_0_train_45929_entity",
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"text": [
"atrolysin C"
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113,
124
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{
"id": "split_0_train_45930_entity",
"type": "progene_text",
"text": [
"proteinases"
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"offsets": [
[
130,
141
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28389
|
split_0_train_28389
|
[
{
"id": "split_0_train_28389_passage",
"type": "progene_text",
"text": [
"Neoepitope antibodies recognizing the N - terminal F ( 342 ) FGVG or C - terminal DIPEN(341) sequences were used to confirm MMP cleavage at the Asn ( 341 ) downward arrow Phe bond , while neoepitope antibodies recognizing the N-terminal A ( 374 ) RGSV or C - terminal ITEGE ( 373 ) sequences were used to confirm aggrecanase cleavage at the Glu ( 373 ) downward arrow Ala bond ."
],
"offsets": [
[
0,
378
]
]
}
] |
[
{
"id": "split_0_train_45931_entity",
"type": "progene_text",
"text": [
"MMP"
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124,
127
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{
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"type": "progene_text",
"text": [
"aggrecanase"
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"offsets": [
[
313,
324
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"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28390
|
split_0_train_28390
|
[
{
"id": "split_0_train_28390_passage",
"type": "progene_text",
"text": [
"Cleavage at the authentic MMP and aggrecanase sites revealed that these proteinases have the same specificity for rG1-G2 as for native aggrecan ."
],
"offsets": [
[
0,
145
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]
}
] |
[
{
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"type": "progene_text",
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{
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34,
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{
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72,
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{
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"type": "progene_text",
"text": [
"aggrecan"
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"offsets": [
[
135,
143
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28391
|
split_0_train_28391
|
[
{
"id": "split_0_train_28391_passage",
"type": "progene_text",
"text": [
"Incubation of rG1-G2 with conditioned medium from porcine cartilage cultures revealed that active soluble aggrecanase but no active MMPs , was released following stimulation with interleukin-1alpha or retinoic acid ."
],
"offsets": [
[
0,
216
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]
}
] |
[
{
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"text": [
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106,
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{
"id": "split_0_train_45938_entity",
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132,
136
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{
"id": "split_0_train_45939_entity",
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"text": [
"interleukin-1alpha"
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"offsets": [
[
179,
197
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"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28392
|
split_0_train_28392
|
[
{
"id": "split_0_train_28392_passage",
"type": "progene_text",
"text": [
"Atrolysin C , which cleaves native bovine aggrecan at both the aggrecanase and MMP sites , efficiently cleaved rG1-G2 at the aggrecanase site but failed to cleave at the MMP site ."
],
"offsets": [
[
0,
180
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]
}
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[
{
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{
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42,
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{
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63,
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{
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79,
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},
{
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125,
136
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{
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"type": "progene_text",
"text": [
"MMP"
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"offsets": [
[
170,
173
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28393
|
split_0_train_28393
|
[
{
"id": "split_0_train_28393_passage",
"type": "progene_text",
"text": [
"In contrast , native glycosylated G1-G2 with or without keratanase treatment was cleaved by atrolysin C at both the aggrecanase and MMP sites ."
],
"offsets": [
[
0,
143
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]
}
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[
{
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{
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{
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"text": [
"aggrecanase"
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116,
127
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{
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"type": "progene_text",
"text": [
"MMP"
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"offsets": [
[
132,
135
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28394
|
split_0_train_28394
|
[
{
"id": "split_0_train_28394_passage",
"type": "progene_text",
"text": [
"The results suggest that the presence or absence per se of keratan sulfate on native G1-G2 does not affect the activity of atrolysin C toward the two sites ."
],
"offsets": [
[
0,
157
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]
}
] |
[
{
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"type": "progene_text",
"text": [
"keratan"
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[
59,
66
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},
{
"id": "split_0_train_45951_entity",
"type": "progene_text",
"text": [
"atrolysin C"
],
"offsets": [
[
123,
134
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28395
|
split_0_train_28395
|
[
{
"id": "split_0_train_28395_passage",
"type": "progene_text",
"text": [
"Phosphatidylinositol 3-kinase requirement in activation of the ras / C-raf-1 / MEK / ERK and p70(s6k) signaling cascade by the insulinomimetic agent vanadyl sulfate ."
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"offsets": [
[
0,
166
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}
] |
[
{
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{
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{
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79,
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},
{
"id": "split_0_train_45956_entity",
"type": "progene_text",
"text": [
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[
85,
88
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},
{
"id": "split_0_train_45957_entity",
"type": "progene_text",
"text": [
"p70(s6k)"
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"offsets": [
[
93,
101
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28396
|
split_0_train_28396
|
[
{
"id": "split_0_train_28396_passage",
"type": "progene_text",
"text": [
"The mechanisms by which inorganic salts of the trace element vanadium mediate their insulinomimetic effects are not clearly understood and were investigated ."
],
"offsets": [
[
0,
158
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28397
|
split_0_train_28397
|
[
{
"id": "split_0_train_28397_passage",
"type": "progene_text",
"text": [
"We have shown previously that vanadium salts activate mitogen - activated protein kinase ( MAPK ) and phosphatidylinositol 3-kinase activities ( PI3 - K ) via a pathway that does not involve the insulin receptor ( IR ) tyrosine kinase function [ Pandey , S. K. , Anand - Srivastava , M. B. , and Srivastava , A. K. ( 1998 ) Biochemistry 37 , 7006 - 7014 ] ."
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"offsets": [
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0,
357
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}
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[
{
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{
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{
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"type": "progene_text",
"text": [
"PI3 - K"
],
"offsets": [
[
145,
152
]
],
"normalized": []
},
{
"id": "split_0_train_45962_entity",
"type": "progene_text",
"text": [
"insulin receptor"
],
"offsets": [
[
195,
211
]
],
"normalized": []
},
{
"id": "split_0_train_45963_entity",
"type": "progene_text",
"text": [
"IR"
],
"offsets": [
[
214,
216
]
],
"normalized": []
},
{
"id": "split_0_train_45964_entity",
"type": "progene_text",
"text": [
"tyrosine kinase"
],
"offsets": [
[
219,
234
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28398
|
split_0_train_28398
|
[
{
"id": "split_0_train_28398_passage",
"type": "progene_text",
"text": [
"Herein , we have examined a possible role of PI3-K in the vanadyl sulfate ( VS ) - mediated increase in the level of ras - MAPK activation as well as the contribution of signaling components upstream to MAPK in this VS response ."
],
"offsets": [
[
0,
229
]
]
}
] |
[
{
"id": "split_0_train_45965_entity",
"type": "progene_text",
"text": [
"PI3-K"
],
"offsets": [
[
45,
50
]
],
"normalized": []
},
{
"id": "split_0_train_45966_entity",
"type": "progene_text",
"text": [
"ras"
],
"offsets": [
[
117,
120
]
],
"normalized": []
},
{
"id": "split_0_train_45967_entity",
"type": "progene_text",
"text": [
"MAPK"
],
"offsets": [
[
123,
127
]
],
"normalized": []
},
{
"id": "split_0_train_45968_entity",
"type": "progene_text",
"text": [
"MAPK"
],
"offsets": [
[
203,
207
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28399
|
split_0_train_28399
|
[
{
"id": "split_0_train_28399_passage",
"type": "progene_text",
"text": [
"Treatment of IR - overexpressing cells with VS resulted in an increased level of tyrosine phosphorylation of p44 ( mapk ) ( ERK-1 ) and p42 ( mapk ) ( ERK-2 ) along with stimulation of MAPK , MAPK kinase ( MEK ) , and C-raf-1 activities , and ras activation ."
],
"offsets": [
[
0,
259
]
]
}
] |
[
{
"id": "split_0_train_45969_entity",
"type": "progene_text",
"text": [
"IR"
],
"offsets": [
[
13,
15
]
],
"normalized": []
},
{
"id": "split_0_train_45970_entity",
"type": "progene_text",
"text": [
"p44 ( mapk )"
],
"offsets": [
[
109,
121
]
],
"normalized": []
},
{
"id": "split_0_train_45971_entity",
"type": "progene_text",
"text": [
"ERK-1"
],
"offsets": [
[
124,
129
]
],
"normalized": []
},
{
"id": "split_0_train_45972_entity",
"type": "progene_text",
"text": [
"p42 ( mapk )"
],
"offsets": [
[
136,
148
]
],
"normalized": []
},
{
"id": "split_0_train_45973_entity",
"type": "progene_text",
"text": [
"ERK-2"
],
"offsets": [
[
151,
156
]
],
"normalized": []
},
{
"id": "split_0_train_45974_entity",
"type": "progene_text",
"text": [
"MAPK"
],
"offsets": [
[
185,
189
]
],
"normalized": []
},
{
"id": "split_0_train_45975_entity",
"type": "progene_text",
"text": [
"MAPK kinase"
],
"offsets": [
[
192,
203
]
],
"normalized": []
},
{
"id": "split_0_train_45976_entity",
"type": "progene_text",
"text": [
"MEK"
],
"offsets": [
[
206,
209
]
],
"normalized": []
},
{
"id": "split_0_train_45977_entity",
"type": "progene_text",
"text": [
"C-raf-1"
],
"offsets": [
[
218,
225
]
],
"normalized": []
},
{
"id": "split_0_train_45978_entity",
"type": "progene_text",
"text": [
"ras"
],
"offsets": [
[
243,
246
]
],
"normalized": []
}
] |
[] |
[] |
[] |
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