id
stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
split_0_train_28500
|
split_0_train_28500
|
[
{
"id": "split_0_train_28500_passage",
"type": "progene_text",
"text": [
"Characterization of a novel DNA primase from the Salmonella typhimurium bacteriophage SP6 ."
],
"offsets": [
[
0,
91
]
]
}
] |
[
{
"id": "split_0_train_46140_entity",
"type": "progene_text",
"text": [
"DNA primase"
],
"offsets": [
[
28,
39
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28501
|
split_0_train_28501
|
[
{
"id": "split_0_train_28501_passage",
"type": "progene_text",
"text": [
"The gene for the DNA primase encoded by Salmonella typhimurium bacteriophage SP6 has been cloned and expressed in Escherichia coli and its 74 - kDa protein product purified to homogeneity ."
],
"offsets": [
[
0,
189
]
]
}
] |
[
{
"id": "split_0_train_46141_entity",
"type": "progene_text",
"text": [
"DNA primase"
],
"offsets": [
[
17,
28
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28502
|
split_0_train_28502
|
[
{
"id": "split_0_train_28502_passage",
"type": "progene_text",
"text": [
"The SP6 primase is a DNA - dependent RNA polymerase that synthesizes short oligoribonucleotides containing each of the four canonical ribonucleotides ."
],
"offsets": [
[
0,
151
]
]
}
] |
[
{
"id": "split_0_train_46142_entity",
"type": "progene_text",
"text": [
"primase"
],
"offsets": [
[
8,
15
]
],
"normalized": []
},
{
"id": "split_0_train_46143_entity",
"type": "progene_text",
"text": [
"DNA - dependent RNA polymerase"
],
"offsets": [
[
21,
51
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28503
|
split_0_train_28503
|
[
{
"id": "split_0_train_28503_passage",
"type": "progene_text",
"text": [
"GTP and CTP are both required for the initiation of oligoribonucleotide synthesis ."
],
"offsets": [
[
0,
83
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28504
|
split_0_train_28504
|
[
{
"id": "split_0_train_28504_passage",
"type": "progene_text",
"text": [
"In reactions containing only GTP and CTP , SP6 primase incorporates GTP at the 5' - end of oligoribonucleotides and CMP at the second position ."
],
"offsets": [
[
0,
144
]
]
}
] |
[
{
"id": "split_0_train_46144_entity",
"type": "progene_text",
"text": [
"primase"
],
"offsets": [
[
47,
54
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28505
|
split_0_train_28505
|
[
{
"id": "split_0_train_28505_passage",
"type": "progene_text",
"text": [
"On synthetic DNA templates , pppGpC dinucleotides are synthesized most rapidly in the presence of the sequence 5 ' - GCA - 3 ' ."
],
"offsets": [
[
0,
128
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28506
|
split_0_train_28506
|
[
{
"id": "split_0_train_28506_passage",
"type": "progene_text",
"text": [
"This trinucleotide sequence , containing a cryptic dA at the 3' - end , differs from other known bacterial and phage primase recognition sites ."
],
"offsets": [
[
0,
144
]
]
}
] |
[
{
"id": "split_0_train_46145_entity",
"type": "progene_text",
"text": [
"primase"
],
"offsets": [
[
117,
124
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28507
|
split_0_train_28507
|
[
{
"id": "split_0_train_28507_passage",
"type": "progene_text",
"text": [
"SP6 primase shares some properties with the well - characterized E. colibacteriophage T7 primase ."
],
"offsets": [
[
0,
98
]
]
}
] |
[
{
"id": "split_0_train_46146_entity",
"type": "progene_text",
"text": [
"primase"
],
"offsets": [
[
4,
11
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],
"normalized": []
},
{
"id": "split_0_train_46147_entity",
"type": "progene_text",
"text": [
"primase"
],
"offsets": [
[
89,
96
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28508
|
split_0_train_28508
|
[
{
"id": "split_0_train_28508_passage",
"type": "progene_text",
"text": [
"The T7 DNA polymerase can use oligoribonucleotides synthesized by SP6 primase as primers for DNA synthesis ."
],
"offsets": [
[
0,
108
]
]
}
] |
[
{
"id": "split_0_train_46148_entity",
"type": "progene_text",
"text": [
"DNA polymerase"
],
"offsets": [
[
7,
21
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],
"normalized": []
},
{
"id": "split_0_train_46149_entity",
"type": "progene_text",
"text": [
"primase"
],
"offsets": [
[
70,
77
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28509
|
split_0_train_28509
|
[
{
"id": "split_0_train_28509_passage",
"type": "progene_text",
"text": [
"However , oligoribonucleotide synthesis by SP6 primase is not stimulated by either the E. coli - or the T7 - encoded ssDNA binding protein ."
],
"offsets": [
[
0,
140
]
]
}
] |
[
{
"id": "split_0_train_46150_entity",
"type": "progene_text",
"text": [
"primase"
],
"offsets": [
[
47,
54
]
],
"normalized": []
},
{
"id": "split_0_train_46151_entity",
"type": "progene_text",
"text": [
"ssDNA binding protein"
],
"offsets": [
[
117,
138
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28510
|
split_0_train_28510
|
[
{
"id": "split_0_train_28510_passage",
"type": "progene_text",
"text": [
"An amino acid sequence alignment of the SP6 and T7 primases , which share only 22.4 % amino acid identity , indicates amino acids likely critical for oligoribonucleotide synthesis as well as a putative Cys ( 3 ) His zinc finger motif that may be involved in DNA binding ."
],
"offsets": [
[
0,
271
]
]
}
] |
[
{
"id": "split_0_train_46152_entity",
"type": "progene_text",
"text": [
"primases"
],
"offsets": [
[
51,
59
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28511
|
split_0_train_28511
|
[
{
"id": "split_0_train_28511_passage",
"type": "progene_text",
"text": [
"Cloning and functional characterization of novel large conductance calcium - activated potassium channel beta subunits , hKCNMB3 and hKCNMB4 ."
],
"offsets": [
[
0,
142
]
]
}
] |
[
{
"id": "split_0_train_46153_entity",
"type": "progene_text",
"text": [
"calcium - activated potassium channel beta"
],
"offsets": [
[
67,
109
]
],
"normalized": []
},
{
"id": "split_0_train_46154_entity",
"type": "progene_text",
"text": [
"hKCNMB3"
],
"offsets": [
[
121,
128
]
],
"normalized": []
},
{
"id": "split_0_train_46155_entity",
"type": "progene_text",
"text": [
"hKCNMB4"
],
"offsets": [
[
133,
140
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28512
|
split_0_train_28512
|
[
{
"id": "split_0_train_28512_passage",
"type": "progene_text",
"text": [
"We present the cloning and characterization of two novel calcium - activated potassium channel beta subunits , hKCNMB3 and hKCNMB4 , that are enriched in the testis and brain , respectively ."
],
"offsets": [
[
0,
191
]
]
}
] |
[
{
"id": "split_0_train_46156_entity",
"type": "progene_text",
"text": [
"calcium - activated potassium channel beta"
],
"offsets": [
[
57,
99
]
],
"normalized": []
},
{
"id": "split_0_train_46157_entity",
"type": "progene_text",
"text": [
"hKCNMB3"
],
"offsets": [
[
111,
118
]
],
"normalized": []
},
{
"id": "split_0_train_46158_entity",
"type": "progene_text",
"text": [
"hKCNMB4"
],
"offsets": [
[
123,
130
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28513
|
split_0_train_28513
|
[
{
"id": "split_0_train_28513_passage",
"type": "progene_text",
"text": [
"We compare and contrast the steady state and kinetic properties of these beta subunits with the previously cloned mouse beta1 ( mKCNMB1 ) and the human beta2 subunit ( hKCNMB2 ) ."
],
"offsets": [
[
0,
179
]
]
}
] |
[
{
"id": "split_0_train_46159_entity",
"type": "progene_text",
"text": [
"mKCNMB1"
],
"offsets": [
[
128,
135
]
],
"normalized": []
},
{
"id": "split_0_train_46160_entity",
"type": "progene_text",
"text": [
"hKCNMB2"
],
"offsets": [
[
168,
175
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28514
|
split_0_train_28514
|
[
{
"id": "split_0_train_28514_passage",
"type": "progene_text",
"text": [
"Once inactivation is removed , we find that hKCNMB2 has properties similar to mKCNMB1 ."
],
"offsets": [
[
0,
87
]
]
}
] |
[
{
"id": "split_0_train_46161_entity",
"type": "progene_text",
"text": [
"hKCNMB2"
],
"offsets": [
[
44,
51
]
],
"normalized": []
},
{
"id": "split_0_train_46162_entity",
"type": "progene_text",
"text": [
"mKCNMB1"
],
"offsets": [
[
78,
85
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28515
|
split_0_train_28515
|
[
{
"id": "split_0_train_28515_passage",
"type": "progene_text",
"text": [
"hKCNMB2 slows Hslo1 channel gating and shifts the current - voltage relationship to more negative potentials ."
],
"offsets": [
[
0,
110
]
]
}
] |
[
{
"id": "split_0_train_46163_entity",
"type": "progene_text",
"text": [
"hKCNMB2"
],
"offsets": [
[
0,
7
]
],
"normalized": []
},
{
"id": "split_0_train_46164_entity",
"type": "progene_text",
"text": [
"Hslo1"
],
"offsets": [
[
14,
19
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28516
|
split_0_train_28516
|
[
{
"id": "split_0_train_28516_passage",
"type": "progene_text",
"text": [
"hKCNMB3 and hKCNMB4 have distinct effects on slo currents not observed with mKCNMB1 and hKCNMB2 ."
],
"offsets": [
[
0,
97
]
]
}
] |
[
{
"id": "split_0_train_46165_entity",
"type": "progene_text",
"text": [
"hKCNMB3"
],
"offsets": [
[
0,
7
]
],
"normalized": []
},
{
"id": "split_0_train_46166_entity",
"type": "progene_text",
"text": [
"hKCNMB4"
],
"offsets": [
[
12,
19
]
],
"normalized": []
},
{
"id": "split_0_train_46167_entity",
"type": "progene_text",
"text": [
"slo"
],
"offsets": [
[
45,
48
]
],
"normalized": []
},
{
"id": "split_0_train_46168_entity",
"type": "progene_text",
"text": [
"mKCNMB1"
],
"offsets": [
[
76,
83
]
],
"normalized": []
},
{
"id": "split_0_train_46169_entity",
"type": "progene_text",
"text": [
"hKCNMB2"
],
"offsets": [
[
88,
95
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28517
|
split_0_train_28517
|
[
{
"id": "split_0_train_28517_passage",
"type": "progene_text",
"text": [
"Although we found that hKCNMB3 does interact with Hslo channels , its effects on Hslo1 channel properties were slight , increasing Hslo1 activation rates ."
],
"offsets": [
[
0,
155
]
]
}
] |
[
{
"id": "split_0_train_46170_entity",
"type": "progene_text",
"text": [
"hKCNMB3"
],
"offsets": [
[
23,
30
]
],
"normalized": []
},
{
"id": "split_0_train_46171_entity",
"type": "progene_text",
"text": [
"Hslo"
],
"offsets": [
[
50,
54
]
],
"normalized": []
},
{
"id": "split_0_train_46172_entity",
"type": "progene_text",
"text": [
"Hslo1"
],
"offsets": [
[
81,
86
]
],
"normalized": []
},
{
"id": "split_0_train_46173_entity",
"type": "progene_text",
"text": [
"Hslo1"
],
"offsets": [
[
131,
136
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28518
|
split_0_train_28518
|
[
{
"id": "split_0_train_28518_passage",
"type": "progene_text",
"text": [
"In contrast , hKCNMB4 slows Hslo1 gating kinetics , and modulates the apparent calcium sensitivity of Hslo1 ."
],
"offsets": [
[
0,
109
]
]
}
] |
[
{
"id": "split_0_train_46174_entity",
"type": "progene_text",
"text": [
"hKCNMB4"
],
"offsets": [
[
14,
21
]
],
"normalized": []
},
{
"id": "split_0_train_46175_entity",
"type": "progene_text",
"text": [
"Hslo1"
],
"offsets": [
[
28,
33
]
],
"normalized": []
},
{
"id": "split_0_train_46176_entity",
"type": "progene_text",
"text": [
"Hslo1"
],
"offsets": [
[
102,
107
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28519
|
split_0_train_28519
|
[
{
"id": "split_0_train_28519_passage",
"type": "progene_text",
"text": [
"We found that the different effects of the beta subunits on some Hslo1 channel properties are calcium - dependent ."
],
"offsets": [
[
0,
115
]
]
}
] |
[
{
"id": "split_0_train_46177_entity",
"type": "progene_text",
"text": [
"Hslo1"
],
"offsets": [
[
65,
70
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28520
|
split_0_train_28520
|
[
{
"id": "split_0_train_28520_passage",
"type": "progene_text",
"text": [
"mKCNMB1 and hKCNMB2 slow activation at 1 microM but not at 10 microM free calcium concentrations ."
],
"offsets": [
[
0,
98
]
]
}
] |
[
{
"id": "split_0_train_46178_entity",
"type": "progene_text",
"text": [
"mKCNMB1"
],
"offsets": [
[
0,
7
]
],
"normalized": []
},
{
"id": "split_0_train_46179_entity",
"type": "progene_text",
"text": [
"hKCNMB2"
],
"offsets": [
[
12,
19
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28521
|
split_0_train_28521
|
[
{
"id": "split_0_train_28521_passage",
"type": "progene_text",
"text": [
"hKCNMB4 decreases Hslo1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations ."
],
"offsets": [
[
0,
134
]
]
}
] |
[
{
"id": "split_0_train_46180_entity",
"type": "progene_text",
"text": [
"hKCNMB4"
],
"offsets": [
[
0,
7
]
],
"normalized": []
},
{
"id": "split_0_train_46181_entity",
"type": "progene_text",
"text": [
"Hslo1"
],
"offsets": [
[
18,
23
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28522
|
split_0_train_28522
|
[
{
"id": "split_0_train_28522_passage",
"type": "progene_text",
"text": [
"These results suggest that beta subunits in diverse tissue types fine - tune slo channel properties to the needs of a particular cell ."
],
"offsets": [
[
0,
135
]
]
}
] |
[
{
"id": "split_0_train_46182_entity",
"type": "progene_text",
"text": [
"slo"
],
"offsets": [
[
77,
80
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28523
|
split_0_train_28523
|
[
{
"id": "split_0_train_28523_passage",
"type": "progene_text",
"text": [
"Bone morphogenetic protein receptor complexes on the surface of live cells : a new oligomerization mode for serine / threonine kinase receptors ."
],
"offsets": [
[
0,
145
]
]
}
] |
[
{
"id": "split_0_train_46183_entity",
"type": "progene_text",
"text": [
"Bone morphogenetic protein receptor"
],
"offsets": [
[
0,
35
]
],
"normalized": []
},
{
"id": "split_0_train_46184_entity",
"type": "progene_text",
"text": [
"serine / threonine kinase receptors"
],
"offsets": [
[
108,
143
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28524
|
split_0_train_28524
|
[
{
"id": "split_0_train_28524_passage",
"type": "progene_text",
"text": [
"The bone morphogenetic proteins ( BMPs ) play important roles in embryogenesis and normal cell growth ."
],
"offsets": [
[
0,
103
]
]
}
] |
[
{
"id": "split_0_train_46185_entity",
"type": "progene_text",
"text": [
"bone morphogenetic proteins"
],
"offsets": [
[
4,
31
]
],
"normalized": []
},
{
"id": "split_0_train_46186_entity",
"type": "progene_text",
"text": [
"BMPs"
],
"offsets": [
[
34,
38
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28525
|
split_0_train_28525
|
[
{
"id": "split_0_train_28525_passage",
"type": "progene_text",
"text": [
"The BMP receptors belong to the family of serine / threonine kinase receptors , whose activation has been investigated intensively for the transforming growth factor - beta ( TGF-beta ) receptor subfamily ."
],
"offsets": [
[
0,
206
]
]
}
] |
[
{
"id": "split_0_train_46187_entity",
"type": "progene_text",
"text": [
"BMP receptors"
],
"offsets": [
[
4,
17
]
],
"normalized": []
},
{
"id": "split_0_train_46188_entity",
"type": "progene_text",
"text": [
"family of serine / threonine kinase receptors"
],
"offsets": [
[
32,
77
]
],
"normalized": []
},
{
"id": "split_0_train_46189_entity",
"type": "progene_text",
"text": [
"transforming growth factor - beta ( TGF-beta ) receptor subfamily"
],
"offsets": [
[
139,
204
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28526
|
split_0_train_28526
|
[
{
"id": "split_0_train_28526_passage",
"type": "progene_text",
"text": [
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] |
[] |
[] |
[] |
split_0_train_28527
|
split_0_train_28527
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"Here we demonstrate that the oligomerization pattern of the BMP receptors is different and is more flexible and susceptible to modulation by ligand ."
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"BMP receptors"
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] |
[] |
[] |
[] |
split_0_train_28528
|
split_0_train_28528
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"id": "split_0_train_28528_passage",
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"Using several complementary approaches , we investigated the formation of homomeric and heteromeric complexes between the two known BMP type I receptors ( BR - Ia and BR - Ib ) and the BMP type II receptor ( BR-II ) ."
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"BR-II"
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208,
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}
] |
[] |
[] |
[] |
split_0_train_28529
|
split_0_train_28529
|
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"text": [
"Coimmunoprecipitation studies detected the formation of heteromeric and homomeric complexes among all the BMP receptor types even in the absence of ligand ."
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106,
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] |
[] |
[] |
[] |
split_0_train_28530
|
split_0_train_28530
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"These complexes were also detected at the cell surface after BMP-2 binding and cross - linking ."
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"text": [
"BMP-2"
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61,
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}
] |
[] |
[] |
[] |
split_0_train_28531
|
split_0_train_28531
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"Using antibody - mediated immunofluorescence copatching of epitope - tagged receptors , we provide evidence in live cells for preexisting heteromeric ( BR - II / BR - Ia and BR - II / BR - Ib ) and homomeric ( BR - II / BR - II , BR - Ia / BR - Ia , BR - Ib / BR - Ib , and also BR-Ia / BR-Ib ) oligomers in the absence of ligand ."
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"text": [
"BR-Ib"
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287,
292
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}
] |
[] |
[] |
[] |
split_0_train_28532
|
split_0_train_28532
|
[
{
"id": "split_0_train_28532_passage",
"type": "progene_text",
"text": [
"BMP-2 binding significantly increased hetero - and homo - oligomerization ( except for the BR - II homo - oligomer , which binds ligand poorly in the absence of BR-I ) ."
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0,
169
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}
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"text": [
"BR-I"
],
"offsets": [
[
161,
165
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28533
|
split_0_train_28533
|
[
{
"id": "split_0_train_28533_passage",
"type": "progene_text",
"text": [
"In contrast to previous observations on TGF-beta receptors , which were found to be fully homodimeric in the absence of ligand , the BMP receptors show a much more flexible oligomerization pattern ."
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[
0,
198
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]
}
] |
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"text": [
"TGF-beta receptors"
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"offsets": [
[
40,
58
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],
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}
] |
[] |
[] |
[] |
split_0_train_28534
|
split_0_train_28534
|
[
{
"id": "split_0_train_28534_passage",
"type": "progene_text",
"text": [
"This novel feature in the oligomerization mode of the BMP receptors allows higher variety and flexibility in their responses to various ligands as compared with the TGF-beta receptors ."
],
"offsets": [
[
0,
185
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]
}
] |
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{
"id": "split_0_train_46216_entity",
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54,
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"text": [
"TGF-beta receptors"
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"offsets": [
[
165,
183
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28535
|
split_0_train_28535
|
[
{
"id": "split_0_train_28535_passage",
"type": "progene_text",
"text": [
"Corrective effects of interleukin-12 on age - related deficiencies in IFN-gamma production and IL-12Rbeta2 expression in virus - specific CD8 + T cells ."
],
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[
0,
153
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]
}
] |
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95,
106
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"type": "progene_text",
"text": [
"CD8"
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"offsets": [
[
138,
141
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28536
|
split_0_train_28536
|
[
{
"id": "split_0_train_28536_passage",
"type": "progene_text",
"text": [
"Interleukin-12 receptor beta2 ( IL-12Rbeta2 ) has been shown to be selectively expressed on Th1 T cell subsets , and we have previously shown that influenza - specific CD8 + cytotoxic T lymphocyte ( CTL ) deficiency in old mice was associated with deficient Th1 ( interferon-gamma [ IFN-gamma]) cytokine production ."
],
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0,
316
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}
] |
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280
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283,
294
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"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
295,
303
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28537
|
split_0_train_28537
|
[
{
"id": "split_0_train_28537_passage",
"type": "progene_text",
"text": [
"This study tested whether IL-12Rbeta2 expression was also deficient in CD8 + CTL from old mice and the effect of IL-12 treatment on these responses ."
],
"offsets": [
[
0,
149
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]
}
] |
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{
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71,
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{
"id": "split_0_train_46230_entity",
"type": "progene_text",
"text": [
"IL-12"
],
"offsets": [
[
113,
118
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28538
|
split_0_train_28538
|
[
{
"id": "split_0_train_28538_passage",
"type": "progene_text",
"text": [
"Splenic lymphocytes from influenza - primed old and young BALB/c mice were stimulated with influenza virus in vitro with and without IL-12 and then enriched for CD8 + T cells ."
],
"offsets": [
[
0,
176
]
]
}
] |
[
{
"id": "split_0_train_46231_entity",
"type": "progene_text",
"text": [
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133,
138
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"type": "progene_text",
"text": [
"CD8"
],
"offsets": [
[
161,
164
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28539
|
split_0_train_28539
|
[
{
"id": "split_0_train_28539_passage",
"type": "progene_text",
"text": [
"IFN-gamma was significantly reduced , whereas IL-4 and IL-12p40 ( an antagonist of IL-12 function ) were evaluated in old when compared with young mice ."
],
"offsets": [
[
0,
153
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]
}
] |
[
{
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{
"id": "split_0_train_46235_entity",
"type": "progene_text",
"text": [
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55,
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{
"id": "split_0_train_46236_entity",
"type": "progene_text",
"text": [
"IL-12"
],
"offsets": [
[
83,
88
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28540
|
split_0_train_28540
|
[
{
"id": "split_0_train_28540_passage",
"type": "progene_text",
"text": [
"This was true for secreted protein measured by ELISA and for mRNA levels quantitated by RT - PCR ."
],
"offsets": [
[
0,
98
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28541
|
split_0_train_28541
|
[
{
"id": "split_0_train_28541_passage",
"type": "progene_text",
"text": [
"IL-12Rbeta2 mRNA expression in CD8 + CTL was also significantly reduced in old mice ."
],
"offsets": [
[
0,
85
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]
}
] |
[
{
"id": "split_0_train_46237_entity",
"type": "progene_text",
"text": [
"IL-12Rbeta2"
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11
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{
"id": "split_0_train_46238_entity",
"type": "progene_text",
"text": [
"CD8"
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"offsets": [
[
31,
34
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28542
|
split_0_train_28542
|
[
{
"id": "split_0_train_28542_passage",
"type": "progene_text",
"text": [
"IL-12 treatment in vitro caused significant upregulation of IFN-gamma and IL-12Rbeta2 and downregulation of IL-4 in CD8 + T cells from old mice and young mice ."
],
"offsets": [
[
0,
160
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]
}
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[
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74,
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{
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"text": [
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108,
112
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{
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"type": "progene_text",
"text": [
"CD8"
],
"offsets": [
[
116,
119
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28543
|
split_0_train_28543
|
[
{
"id": "split_0_train_28543_passage",
"type": "progene_text",
"text": [
"The present demonstration of an age - related downregulation in IL-12Rbeta2 expression and our previous data showing reduced IFN-gamma and elevated IL-4 production provide strong evidence that CD8 + CTL deficiency in aging results from a Th1 / Th2 cytokine production switch ."
],
"offsets": [
[
0,
276
]
]
}
] |
[
{
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{
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125,
134
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{
"id": "split_0_train_46246_entity",
"type": "progene_text",
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148,
152
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{
"id": "split_0_train_46247_entity",
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"text": [
"CD8"
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193,
196
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{
"id": "split_0_train_46248_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
248,
256
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28544
|
split_0_train_28544
|
[
{
"id": "split_0_train_28544_passage",
"type": "progene_text",
"text": [
"Agents that increase IL-12Rbeta2 expression and redirect Th2 to Thl immune responses are likely to enhance CD8 + CTL - mediated control of viral infections in aging ."
],
"offsets": [
[
0,
166
]
]
}
] |
[
{
"id": "split_0_train_46249_entity",
"type": "progene_text",
"text": [
"IL-12Rbeta2"
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[
21,
32
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{
"id": "split_0_train_46250_entity",
"type": "progene_text",
"text": [
"CD8"
],
"offsets": [
[
107,
110
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28545
|
split_0_train_28545
|
[
{
"id": "split_0_train_28545_passage",
"type": "progene_text",
"text": [
"Elucidating the essential role of the A14 phosphoprotein in vaccinia virus morphogenesis : construction and characterization of a tetracycline - inducible recombinant ."
],
"offsets": [
[
0,
168
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]
}
] |
[
{
"id": "split_0_train_46251_entity",
"type": "progene_text",
"text": [
"A14"
],
"offsets": [
[
38,
41
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28546
|
split_0_train_28546
|
[
{
"id": "split_0_train_28546_passage",
"type": "progene_text",
"text": [
"We have previously reported the construction and characterization of vindH1 , an inducible recombinant in which expression of the vaccinia virus H1 phosphatase is regulated experimentally by IPTG ( isopropyl - beta - D - thiogalactopyranoside ) ( 35 ) ."
],
"offsets": [
[
0,
253
]
]
}
] |
[
{
"id": "split_0_train_46252_entity",
"type": "progene_text",
"text": [
"H1 phosphatase"
],
"offsets": [
[
145,
159
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28547
|
split_0_train_28547
|
[
{
"id": "split_0_train_28547_passage",
"type": "progene_text",
"text": [
"In the absence of H1 expression , the transcriptional competence and infectivity of nascent virions are severely compromised ."
],
"offsets": [
[
0,
126
]
]
}
] |
[
{
"id": "split_0_train_46253_entity",
"type": "progene_text",
"text": [
"H1"
],
"offsets": [
[
18,
20
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28548
|
split_0_train_28548
|
[
{
"id": "split_0_train_28548_passage",
"type": "progene_text",
"text": [
"We have sought to identify H1 substrates by characterizing proteins that are hyperphosphorylated in H1 - deficient virions ."
],
"offsets": [
[
0,
124
]
]
}
] |
[
{
"id": "split_0_train_46254_entity",
"type": "progene_text",
"text": [
"H1"
],
"offsets": [
[
27,
29
]
],
"normalized": []
},
{
"id": "split_0_train_46255_entity",
"type": "progene_text",
"text": [
"H1"
],
"offsets": [
[
100,
102
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28549
|
split_0_train_28549
|
[
{
"id": "split_0_train_28549_passage",
"type": "progene_text",
"text": [
"Here , we demonstrate that the A14 protein , a component of the virion membrane , is indeed an H1 phosphatase substrate in vivo and in vitro ."
],
"offsets": [
[
0,
142
]
]
}
] |
[
{
"id": "split_0_train_46256_entity",
"type": "progene_text",
"text": [
"A14"
],
"offsets": [
[
31,
34
]
],
"normalized": []
},
{
"id": "split_0_train_46257_entity",
"type": "progene_text",
"text": [
"H1 phosphatase"
],
"offsets": [
[
95,
109
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28550
|
split_0_train_28550
|
[
{
"id": "split_0_train_28550_passage",
"type": "progene_text",
"text": [
"A14 is hyperphosphorylated on serine residues in the absence of H1 expression ."
],
"offsets": [
[
0,
79
]
]
}
] |
[
{
"id": "split_0_train_46258_entity",
"type": "progene_text",
"text": [
"A14"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "split_0_train_46259_entity",
"type": "progene_text",
"text": [
"H1"
],
"offsets": [
[
64,
66
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28551
|
split_0_train_28551
|
[
{
"id": "split_0_train_28551_passage",
"type": "progene_text",
"text": [
"To enable a genetic analysis of A14 's function during the viral life cycle , we have adopted the regulatory components of the tetracycline ( TET ) operon and created new reagents for the construction of TET - inducible vaccinia virus recombinants ."
],
"offsets": [
[
0,
249
]
]
}
] |
[
{
"id": "split_0_train_46260_entity",
"type": "progene_text",
"text": [
"A14"
],
"offsets": [
[
32,
35
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28552
|
split_0_train_28552
|
[
{
"id": "split_0_train_28552_passage",
"type": "progene_text",
"text": [
"In the context of a virus expressing the TET repressor ( tetR ) , insertion of the TET operator between the transcriptional and translational start sites of a late viral gene enables its expression to be tightly regulated by TET ."
],
"offsets": [
[
0,
230
]
]
}
] |
[
{
"id": "split_0_train_46261_entity",
"type": "progene_text",
"text": [
"TET repressor"
],
"offsets": [
[
41,
54
]
],
"normalized": []
},
{
"id": "split_0_train_46262_entity",
"type": "progene_text",
"text": [
"tetR"
],
"offsets": [
[
57,
61
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28553
|
split_0_train_28553
|
[
{
"id": "split_0_train_28553_passage",
"type": "progene_text",
"text": [
"We constructed a TET - inducible recombinant for the A14 gene , vindA14 ."
],
"offsets": [
[
0,
73
]
]
}
] |
[
{
"id": "split_0_train_46263_entity",
"type": "progene_text",
"text": [
"A14"
],
"offsets": [
[
53,
56
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28554
|
split_0_train_28554
|
[
{
"id": "split_0_train_28554_passage",
"type": "progene_text",
"text": [
"In the absence of TET , vindA14 fails to form plaques and the 24 - h yield of infectious progeny is reduced by 3 orders of magnitude ."
],
"offsets": [
[
0,
134
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28555
|
split_0_train_28555
|
[
{
"id": "split_0_train_28555_passage",
"type": "progene_text",
"text": [
"The infection arrests early during viral morphogenesis , with the accumulation of large numbers of vesicles and the appearance of \" empty \" crescents that appear to adhere only loosely to virosomes ."
],
"offsets": [
[
0,
199
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28556
|
split_0_train_28556
|
[
{
"id": "split_0_train_28556_passage",
"type": "progene_text",
"text": [
"This phenotype corresponds closely to that observed for an IPTG - inducible A14 recombinant whose construction and characterization were reported while our work was ongoing ( 47 ) ."
],
"offsets": [
[
0,
181
]
]
}
] |
[
{
"id": "split_0_train_46264_entity",
"type": "progene_text",
"text": [
"A14"
],
"offsets": [
[
76,
79
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28557
|
split_0_train_28557
|
[
{
"id": "split_0_train_28557_passage",
"type": "progene_text",
"text": [
"The consistency in the phenotypes seen for the IPTG - and TET - inducible recombinants confirms the efficacy of the TET - inducible system and reinforces the value of having a second , independent system available for generating inducible recombinants ."
],
"offsets": [
[
0,
253
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28558
|
split_0_train_28558
|
[
{
"id": "split_0_train_28558_passage",
"type": "progene_text",
"text": [
"Nutritonal evaluation of pemphigus foliaceus patients on long term glucocorticoid therapy ."
],
"offsets": [
[
0,
91
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28559
|
split_0_train_28559
|
[
{
"id": "split_0_train_28559_passage",
"type": "progene_text",
"text": [
"Our objective was to compare food intake and nutritional status of Pemphigus Foliaceus patients ( PG ) on long term glucocorticoid therapy to a Control Group ( CG ) ."
],
"offsets": [
[
0,
166
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28560
|
split_0_train_28560
|
[
{
"id": "split_0_train_28560_passage",
"type": "progene_text",
"text": [
"Fourteen PG female inpatients receiving prednisone ( 0.33 +/- 0.22mg / kg ) for at least 12 months and twelve CG subjects were submitted to nutritional evaluation , including anthropometry , urinary creatinine determination and serum biochemical measurements , besides 48 - h - based food intake records ."
],
"offsets": [
[
0,
305
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28561
|
split_0_train_28561
|
[
{
"id": "split_0_train_28561_passage",
"type": "progene_text",
"text": [
"Groups were compared by Chi - square , Mann - Whitney and \" t \" tests ."
],
"offsets": [
[
0,
71
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28562
|
split_0_train_28562
|
[
{
"id": "split_0_train_28562_passage",
"type": "progene_text",
"text": [
"PG patients and CG were paired , respectively , in relation to age ( 24.7 +/- 14.1 vs. 22.0 +/- 12.0 years ) , body mass index ( 25.8 +/- 6.4 vs. 24.0 +/- 5.6kg / m2 ) , daily protein intake ( 132.9 +/- 49.8 vs. 95.2 +/- 58.9g ) , and serum albumin ( median ; range ) ( 3.8 ; 3.5 - 4.1 vs. 3.8 ; 3.6-5.0g / dl ) ."
],
"offsets": [
[
0,
313
]
]
}
] |
[
{
"id": "split_0_train_46265_entity",
"type": "progene_text",
"text": [
"serum albumin"
],
"offsets": [
[
235,
248
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28563
|
split_0_train_28563
|
[
{
"id": "split_0_train_28563_passage",
"type": "progene_text",
"text": [
"However , PG patients had lower height - creatinine index ( 64.8 +/- 17.6 vs. 90.1 +/- 33.4 % ) , and higher daily energy ( 3080 +/- 1099 vs. 2187 +/- 702kcal ) and carbohydrate ( 376.8 +/- 135.8 vs. 242.0 +/- 80.7g ) intakes ."
],
"offsets": [
[
0,
227
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28564
|
split_0_train_28564
|
[
{
"id": "split_0_train_28564_passage",
"type": "progene_text",
"text": [
"Despite high food , protein and energy consumption , PG patients on long term glucocorticoid therapy had lower body muscle mass than controls , while showing high body fat stores ."
],
"offsets": [
[
0,
180
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28565
|
split_0_train_28565
|
[
{
"id": "split_0_train_28565_passage",
"type": "progene_text",
"text": [
"These findings are possibly related to combined metabolic effects of long term corticotherapy and inflammatory disease plus corticosteroid - induced increased appetite ."
],
"offsets": [
[
0,
169
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28566
|
split_0_train_28566
|
[
{
"id": "split_0_train_28566_passage",
"type": "progene_text",
"text": [
"Characterization of elements mediating regulation of phosphoenolpyruvate carboxykinase gene transcription by protein kinase A and insulin ."
],
"offsets": [
[
0,
139
]
]
}
] |
[
{
"id": "split_0_train_46266_entity",
"type": "progene_text",
"text": [
"phosphoenolpyruvate carboxykinase"
],
"offsets": [
[
53,
86
]
],
"normalized": []
},
{
"id": "split_0_train_46267_entity",
"type": "progene_text",
"text": [
"protein kinase A"
],
"offsets": [
[
109,
125
]
],
"normalized": []
},
{
"id": "split_0_train_46268_entity",
"type": "progene_text",
"text": [
"insulin"
],
"offsets": [
[
130,
137
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28567
|
split_0_train_28567
|
[
{
"id": "split_0_train_28567_passage",
"type": "progene_text",
"text": [
"Identification of a distinct complex formed in cells that mediate insulin inhibition ."
],
"offsets": [
[
0,
86
]
]
}
] |
[
{
"id": "split_0_train_46269_entity",
"type": "progene_text",
"text": [
"insulin"
],
"offsets": [
[
66,
73
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28568
|
split_0_train_28568
|
[
{
"id": "split_0_train_28568_passage",
"type": "progene_text",
"text": [
"The in vivo pattern of induction of phosphoenolpyruvate carboxykinase ( PEPCK ) gene transcription by cAMP and its inhibition by insulin is reproduced in H4IIe cells and is mediated by a bipartite cAMP / insulin response unit ( C / IRU ) consisting of a cAMP response element (-95 / - 87 ) and an upstream enhancer , AC (-271 / - 225 ) ."
],
"offsets": [
[
0,
337
]
]
}
] |
[
{
"id": "split_0_train_46270_entity",
"type": "progene_text",
"text": [
"phosphoenolpyruvate carboxykinase"
],
"offsets": [
[
36,
69
]
],
"normalized": []
},
{
"id": "split_0_train_46271_entity",
"type": "progene_text",
"text": [
"PEPCK"
],
"offsets": [
[
72,
77
]
],
"normalized": []
},
{
"id": "split_0_train_46272_entity",
"type": "progene_text",
"text": [
"insulin"
],
"offsets": [
[
129,
136
]
],
"normalized": []
},
{
"id": "split_0_train_46273_entity",
"type": "progene_text",
"text": [
"insulin"
],
"offsets": [
[
204,
211
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28569
|
split_0_train_28569
|
[
{
"id": "split_0_train_28569_passage",
"type": "progene_text",
"text": [
"Studies in HepG2 cells showed that binding of AP-1 and CAAT / enhancer - binding protein ( C / EBP ) to AC is required for induction by cAMP , but insulin did not inhibit cAMP - induced PEPCK expression in HepG2 cells ."
],
"offsets": [
[
0,
219
]
]
}
] |
[
{
"id": "split_0_train_46274_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
46,
50
]
],
"normalized": []
},
{
"id": "split_0_train_46275_entity",
"type": "progene_text",
"text": [
"CAAT / enhancer - binding protein"
],
"offsets": [
[
55,
88
]
],
"normalized": []
},
{
"id": "split_0_train_46276_entity",
"type": "progene_text",
"text": [
"C / EBP"
],
"offsets": [
[
91,
98
]
],
"normalized": []
},
{
"id": "split_0_train_46277_entity",
"type": "progene_text",
"text": [
"insulin"
],
"offsets": [
[
147,
154
]
],
"normalized": []
},
{
"id": "split_0_train_46278_entity",
"type": "progene_text",
"text": [
"PEPCK"
],
"offsets": [
[
186,
191
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28570
|
split_0_train_28570
|
[
{
"id": "split_0_train_28570_passage",
"type": "progene_text",
"text": [
"Binding of H4IIe nuclear proteins to an AC element probe was inhibited by antibodies or a consensus site for C / EBP , but not AP-1 ."
],
"offsets": [
[
0,
133
]
]
}
] |
[
{
"id": "split_0_train_46279_entity",
"type": "progene_text",
"text": [
"C / EBP"
],
"offsets": [
[
109,
116
]
],
"normalized": []
},
{
"id": "split_0_train_46280_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
127,
131
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28571
|
split_0_train_28571
|
[
{
"id": "split_0_train_28571_passage",
"type": "progene_text",
"text": [
"Transfection with dominant negative bZIP factors , which prevent endogenous factors from binding to DNA , showed that elimination of cAMP regulatory element - binding protein CREB or C / EBP activity blocked induction by protein kinase A ( PKA ) , whereas elimination of AP-1 activity had no effect ."
],
"offsets": [
[
0,
300
]
]
}
] |
[
{
"id": "split_0_train_46281_entity",
"type": "progene_text",
"text": [
"cAMP regulatory element - binding protein"
],
"offsets": [
[
133,
174
]
],
"normalized": []
},
{
"id": "split_0_train_46282_entity",
"type": "progene_text",
"text": [
"CREB"
],
"offsets": [
[
175,
179
]
],
"normalized": []
},
{
"id": "split_0_train_46283_entity",
"type": "progene_text",
"text": [
"C / EBP"
],
"offsets": [
[
183,
190
]
],
"normalized": []
},
{
"id": "split_0_train_46284_entity",
"type": "progene_text",
"text": [
"protein kinase A"
],
"offsets": [
[
221,
237
]
],
"normalized": []
},
{
"id": "split_0_train_46285_entity",
"type": "progene_text",
"text": [
"PKA"
],
"offsets": [
[
240,
243
]
],
"normalized": []
},
{
"id": "split_0_train_46286_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
271,
275
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28572
|
split_0_train_28572
|
[
{
"id": "split_0_train_28572_passage",
"type": "progene_text",
"text": [
"In addition , promoters with multiple CREB sites , or a single CREB site and multiple C / EBP sites , mediated PKA induction , but this was inhibited to no greater extent than basal activity was by insulin ."
],
"offsets": [
[
0,
207
]
]
}
] |
[
{
"id": "split_0_train_46287_entity",
"type": "progene_text",
"text": [
"CREB"
],
"offsets": [
[
38,
42
]
],
"normalized": []
},
{
"id": "split_0_train_46288_entity",
"type": "progene_text",
"text": [
"CREB"
],
"offsets": [
[
63,
67
]
],
"normalized": []
},
{
"id": "split_0_train_46289_entity",
"type": "progene_text",
"text": [
"C / EBP"
],
"offsets": [
[
86,
93
]
],
"normalized": []
},
{
"id": "split_0_train_46290_entity",
"type": "progene_text",
"text": [
"PKA"
],
"offsets": [
[
111,
114
]
],
"normalized": []
},
{
"id": "split_0_train_46291_entity",
"type": "progene_text",
"text": [
"insulin"
],
"offsets": [
[
198,
205
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28573
|
split_0_train_28573
|
[
{
"id": "split_0_train_28573_passage",
"type": "progene_text",
"text": [
"These results indicate that an AC factor other than C / EBP must mediate insulin inhibition ."
],
"offsets": [
[
0,
93
]
]
}
] |
[
{
"id": "split_0_train_46292_entity",
"type": "progene_text",
"text": [
"C / EBP"
],
"offsets": [
[
52,
59
]
],
"normalized": []
},
{
"id": "split_0_train_46293_entity",
"type": "progene_text",
"text": [
"insulin"
],
"offsets": [
[
73,
80
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28574
|
split_0_train_28574
|
[
{
"id": "split_0_train_28574_passage",
"type": "progene_text",
"text": [
"An A-site probe ( - 265 / - 247 ) or a probe across the middle of the AC element ( - 256 / - 237 ) competed for complexes formed by factors other than AP-1 or C / EBP ."
],
"offsets": [
[
0,
168
]
]
}
] |
[
{
"id": "split_0_train_46294_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
151,
155
]
],
"normalized": []
},
{
"id": "split_0_train_46295_entity",
"type": "progene_text",
"text": [
"C / EBP"
],
"offsets": [
[
159,
166
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28575
|
split_0_train_28575
|
[
{
"id": "split_0_train_28575_passage",
"type": "progene_text",
"text": [
"However , analysis of competitor oligonucleotides and antibodies for candidate factors failed to identify other factors ."
],
"offsets": [
[
0,
121
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28576
|
split_0_train_28576
|
[
{
"id": "split_0_train_28576_passage",
"type": "progene_text",
"text": [
"Scanning mutations throughout the AC element interfered with induction but allowed us to define five overlapping sites for regulatory factors in AC and to design probes binding just one or two factors ."
],
"offsets": [
[
0,
202
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28577
|
split_0_train_28577
|
[
{
"id": "split_0_train_28577_passage",
"type": "progene_text",
"text": [
"Comparison of the protein - DNA complexes formed on these smaller probes revealed that a specific complex present in rat liver and H4IIe cell nuclear extracts differed from those formed by HepG2 cell nuclear extracts ."
],
"offsets": [
[
0,
218
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28578
|
split_0_train_28578
|
[
{
"id": "split_0_train_28578_passage",
"type": "progene_text",
"text": [
"Our results suggest that multiple factors binding the AC element of the C / IRU interact with each other and CREB to regulate PEPCK induction by cAMP and inhibition by insulin and that the unique factor expressed in H4IIe cells is a candidate for involvement in insulin regulation of PKA - induced PEPCK gene transcription ."
],
"offsets": [
[
0,
324
]
]
}
] |
[
{
"id": "split_0_train_46296_entity",
"type": "progene_text",
"text": [
"CREB"
],
"offsets": [
[
109,
113
]
],
"normalized": []
},
{
"id": "split_0_train_46297_entity",
"type": "progene_text",
"text": [
"PEPCK"
],
"offsets": [
[
126,
131
]
],
"normalized": []
},
{
"id": "split_0_train_46298_entity",
"type": "progene_text",
"text": [
"insulin"
],
"offsets": [
[
168,
175
]
],
"normalized": []
},
{
"id": "split_0_train_46299_entity",
"type": "progene_text",
"text": [
"insulin"
],
"offsets": [
[
262,
269
]
],
"normalized": []
},
{
"id": "split_0_train_46300_entity",
"type": "progene_text",
"text": [
"PKA"
],
"offsets": [
[
284,
287
]
],
"normalized": []
},
{
"id": "split_0_train_46301_entity",
"type": "progene_text",
"text": [
"PEPCK"
],
"offsets": [
[
298,
303
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28579
|
split_0_train_28579
|
[
{
"id": "split_0_train_28579_passage",
"type": "progene_text",
"text": [
"A new mutation in spo0A with intragenic suppressors in the effector domain ."
],
"offsets": [
[
0,
76
]
]
}
] |
[
{
"id": "split_0_train_46302_entity",
"type": "progene_text",
"text": [
"spo0A"
],
"offsets": [
[
18,
23
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28580
|
split_0_train_28580
|
[
{
"id": "split_0_train_28580_passage",
"type": "progene_text",
"text": [
"Spo0A is a two domain response regulator , a key protein in the initiation of sporulation of Bacillus subtilis ."
],
"offsets": [
[
0,
112
]
]
}
] |
[
{
"id": "split_0_train_46303_entity",
"type": "progene_text",
"text": [
"Spo0A"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "split_0_train_46304_entity",
"type": "progene_text",
"text": [
"response regulator"
],
"offsets": [
[
22,
40
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28581
|
split_0_train_28581
|
[
{
"id": "split_0_train_28581_passage",
"type": "progene_text",
"text": [
"This protein controls a number of changes in gene expression that occur during the transition from stationary phase to the onset of sporulation ."
],
"offsets": [
[
0,
145
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28582
|
split_0_train_28582
|
[
{
"id": "split_0_train_28582_passage",
"type": "progene_text",
"text": [
"The phosphorylated form of Spo0A influences the transcription of a specific set of genes ."
],
"offsets": [
[
0,
90
]
]
}
] |
[
{
"id": "split_0_train_46305_entity",
"type": "progene_text",
"text": [
"Spo0A"
],
"offsets": [
[
27,
32
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28583
|
split_0_train_28583
|
[
{
"id": "split_0_train_28583_passage",
"type": "progene_text",
"text": [
"In addition to others , it represses abrB and activates spoIIA and spoIIE transcription ."
],
"offsets": [
[
0,
89
]
]
}
] |
[
{
"id": "split_0_train_46306_entity",
"type": "progene_text",
"text": [
"abrB"
],
"offsets": [
[
37,
41
]
],
"normalized": []
},
{
"id": "split_0_train_46307_entity",
"type": "progene_text",
"text": [
"spoIIA"
],
"offsets": [
[
56,
62
]
],
"normalized": []
},
{
"id": "split_0_train_46308_entity",
"type": "progene_text",
"text": [
"spoIIE"
],
"offsets": [
[
67,
73
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28584
|
split_0_train_28584
|
[
{
"id": "split_0_train_28584_passage",
"type": "progene_text",
"text": [
"Although the N - terminal phosphoacceptor domain is well characterised , there is limited information on the C - terminal , DNA - binding domain ."
],
"offsets": [
[
0,
146
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28585
|
split_0_train_28585
|
[
{
"id": "split_0_train_28585_passage",
"type": "progene_text",
"text": [
"Comparisons of Spo0A homologues from a number of Bacillus and Clostridium species show that the C - terminal domain contains three highly conserved regions ."
],
"offsets": [
[
0,
157
]
]
}
] |
[
{
"id": "split_0_train_46309_entity",
"type": "progene_text",
"text": [
"Spo0A"
],
"offsets": [
[
15,
20
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28586
|
split_0_train_28586
|
[
{
"id": "split_0_train_28586_passage",
"type": "progene_text",
"text": [
"In this study , we have investigated the influence of spo0A mutations mapping within the C - terminal domain on transcription from the abrB , spoIIA and spoIIE promoters using lacZ fusions ."
],
"offsets": [
[
0,
190
]
]
}
] |
[
{
"id": "split_0_train_46310_entity",
"type": "progene_text",
"text": [
"spo0A"
],
"offsets": [
[
54,
59
]
],
"normalized": []
},
{
"id": "split_0_train_46311_entity",
"type": "progene_text",
"text": [
"abrB"
],
"offsets": [
[
135,
139
]
],
"normalized": []
},
{
"id": "split_0_train_46312_entity",
"type": "progene_text",
"text": [
"spoIIA"
],
"offsets": [
[
142,
148
]
],
"normalized": []
},
{
"id": "split_0_train_46313_entity",
"type": "progene_text",
"text": [
"spoIIE"
],
"offsets": [
[
153,
159
]
],
"normalized": []
},
{
"id": "split_0_train_46314_entity",
"type": "progene_text",
"text": [
"lacZ"
],
"offsets": [
[
176,
180
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28587
|
split_0_train_28587
|
[
{
"id": "split_0_train_28587_passage",
"type": "progene_text",
"text": [
"Our results indicate that described mutations can be part of signalling between N - and C - terminal domains of the protein ."
],
"offsets": [
[
0,
125
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28588
|
split_0_train_28588
|
[
{
"id": "split_0_train_28588_passage",
"type": "progene_text",
"text": [
"Also , the increased expression observed from the spoIIE promoter in some Spo0A mutants might result from a stabilising function of these mutations on the transcriptional apparatus utilising sigma ( A ) ."
],
"offsets": [
[
0,
204
]
]
}
] |
[
{
"id": "split_0_train_46315_entity",
"type": "progene_text",
"text": [
"spoIIE"
],
"offsets": [
[
50,
56
]
],
"normalized": []
},
{
"id": "split_0_train_46316_entity",
"type": "progene_text",
"text": [
"Spo0A"
],
"offsets": [
[
74,
79
]
],
"normalized": []
},
{
"id": "split_0_train_46317_entity",
"type": "progene_text",
"text": [
"sigma ( A )"
],
"offsets": [
[
191,
202
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28589
|
split_0_train_28589
|
[
{
"id": "split_0_train_28589_passage",
"type": "progene_text",
"text": [
"DNA methyltransferase levels and altered CpG methylation in the total genome and in the GSTP1 gene in human glioma cells transfected with sense and antisense DNA methyltransferase cDNA ."
],
"offsets": [
[
0,
186
]
]
}
] |
[
{
"id": "split_0_train_46318_entity",
"type": "progene_text",
"text": [
"DNA methyltransferase"
],
"offsets": [
[
0,
21
]
],
"normalized": []
},
{
"id": "split_0_train_46319_entity",
"type": "progene_text",
"text": [
"GSTP1"
],
"offsets": [
[
88,
93
]
],
"normalized": []
},
{
"id": "split_0_train_46320_entity",
"type": "progene_text",
"text": [
"methyltransferase"
],
"offsets": [
[
162,
179
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28590
|
split_0_train_28590
|
[
{
"id": "split_0_train_28590_passage",
"type": "progene_text",
"text": [
"This study examines the efficacy of using plasmid expression vectors containing sense and antisense DNA MTase cDNA to both up - and downregulate intracellular DNA MTase levels in human glioma cells ."
],
"offsets": [
[
0,
199
]
]
}
] |
[
{
"id": "split_0_train_46321_entity",
"type": "progene_text",
"text": [
"DNA MTase"
],
"offsets": [
[
100,
109
]
],
"normalized": []
},
{
"id": "split_0_train_46322_entity",
"type": "progene_text",
"text": [
"DNA MTase"
],
"offsets": [
[
159,
168
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28591
|
split_0_train_28591
|
[
{
"id": "split_0_train_28591_passage",
"type": "progene_text",
"text": [
"The effects of the changes in MTase levels on global genomic DNA methylation and on the methylation status of CpG dinucleotides in the GSTP1 gene were determined in a glioma cell line that overexpresses the GSTP1 gene ."
],
"offsets": [
[
0,
219
]
]
}
] |
[
{
"id": "split_0_train_46323_entity",
"type": "progene_text",
"text": [
"MTase"
],
"offsets": [
[
30,
35
]
],
"normalized": []
},
{
"id": "split_0_train_46324_entity",
"type": "progene_text",
"text": [
"GSTP1"
],
"offsets": [
[
135,
140
]
],
"normalized": []
},
{
"id": "split_0_train_46325_entity",
"type": "progene_text",
"text": [
"GSTP1"
],
"offsets": [
[
207,
212
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28592
|
split_0_train_28592
|
[
{
"id": "split_0_train_28592_passage",
"type": "progene_text",
"text": [
"In cells transfected with sense DNA MTase cDNA , MTase gene transcripts increased to a maximum of 2 ."
],
"offsets": [
[
0,
101
]
]
}
] |
[
{
"id": "split_0_train_46326_entity",
"type": "progene_text",
"text": [
"DNA MTase"
],
"offsets": [
[
32,
41
]
],
"normalized": []
},
{
"id": "split_0_train_46327_entity",
"type": "progene_text",
"text": [
"MTase"
],
"offsets": [
[
49,
54
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28593
|
split_0_train_28593
|
[
{
"id": "split_0_train_28593_passage",
"type": "progene_text",
"text": [
"5 - fold at 24 h , while MTase activity increased to a maximum of 3 ."
],
"offsets": [
[
0,
69
]
]
}
] |
[
{
"id": "split_0_train_46328_entity",
"type": "progene_text",
"text": [
"MTase"
],
"offsets": [
[
25,
30
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28594
|
split_0_train_28594
|
[
{
"id": "split_0_train_28594_passage",
"type": "progene_text",
"text": [
"6 - fold at 48 h ."
],
"offsets": [
[
0,
18
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28595
|
split_0_train_28595
|
[
{
"id": "split_0_train_28595_passage",
"type": "progene_text",
"text": [
"The effects of antisense MTase cDNA transfections were less pronounced , and levels of MTase gene transcripts and enzyme activity in transfectants were decreased to only , approximately , one-half the levels of controls ."
],
"offsets": [
[
0,
221
]
]
}
] |
[
{
"id": "split_0_train_46329_entity",
"type": "progene_text",
"text": [
"MTase"
],
"offsets": [
[
25,
30
]
],
"normalized": []
},
{
"id": "split_0_train_46330_entity",
"type": "progene_text",
"text": [
"MTase"
],
"offsets": [
[
87,
92
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28596
|
split_0_train_28596
|
[
{
"id": "split_0_train_28596_passage",
"type": "progene_text",
"text": [
"The alterations in DNA MTase expression were associated with corresponding changes in the level of global DNA methylation and in the methylation of the GSTP1 gene in the cells , however , with no detectable morphological or cytotoxic effects on the cells ."
],
"offsets": [
[
0,
256
]
]
}
] |
[
{
"id": "split_0_train_46331_entity",
"type": "progene_text",
"text": [
"DNA MTase"
],
"offsets": [
[
19,
28
]
],
"normalized": []
},
{
"id": "split_0_train_46332_entity",
"type": "progene_text",
"text": [
"GSTP1"
],
"offsets": [
[
152,
157
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28597
|
split_0_train_28597
|
[
{
"id": "split_0_train_28597_passage",
"type": "progene_text",
"text": [
"No significant changes in GSTP1 gene expression were detected after the transfections , presumably because of the high levels of basal GSTP1 expression in the cells ."
],
"offsets": [
[
0,
166
]
]
}
] |
[
{
"id": "split_0_train_46333_entity",
"type": "progene_text",
"text": [
"GSTP1"
],
"offsets": [
[
26,
31
]
],
"normalized": []
},
{
"id": "split_0_train_46334_entity",
"type": "progene_text",
"text": [
"GSTP1"
],
"offsets": [
[
135,
140
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28598
|
split_0_train_28598
|
[
{
"id": "split_0_train_28598_passage",
"type": "progene_text",
"text": [
"Consequently , the p16 gene , known to be repressed transcriptionally by DNA methylation , was examined for the functional effects of the altered MTase levels ."
],
"offsets": [
[
0,
160
]
]
}
] |
[
{
"id": "split_0_train_46335_entity",
"type": "progene_text",
"text": [
"p16"
],
"offsets": [
[
19,
22
]
],
"normalized": []
},
{
"id": "split_0_train_46336_entity",
"type": "progene_text",
"text": [
"MTase"
],
"offsets": [
[
146,
151
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28599
|
split_0_train_28599
|
[
{
"id": "split_0_train_28599_passage",
"type": "progene_text",
"text": [
"The results showed a 2 - fold decrease in p16 gene transcripts with the sense MTase transfectants , while in the MTase antisense - transfected cells p16 transcript levels increased by 30 % ."
],
"offsets": [
[
0,
190
]
]
}
] |
[
{
"id": "split_0_train_46337_entity",
"type": "progene_text",
"text": [
"p16"
],
"offsets": [
[
42,
45
]
],
"normalized": []
},
{
"id": "split_0_train_46338_entity",
"type": "progene_text",
"text": [
"MTase"
],
"offsets": [
[
78,
83
]
],
"normalized": []
},
{
"id": "split_0_train_46339_entity",
"type": "progene_text",
"text": [
"MTase"
],
"offsets": [
[
113,
118
]
],
"normalized": []
},
{
"id": "split_0_train_46340_entity",
"type": "progene_text",
"text": [
"p16"
],
"offsets": [
[
149,
152
]
],
"normalized": []
}
] |
[] |
[] |
[] |
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