id
stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
split_0_train_28600
|
split_0_train_28600
|
[
{
"id": "split_0_train_28600_passage",
"type": "progene_text",
"text": [
"Together , these results demonstrate the feasibility of using both sense and antisense DNA MTase expression vectors to regulate DNA MTase levels in glioma cells and that , over relatively short periods of time , the alterations in MTase activities are not deleterious to the cells ."
],
"offsets": [
[
0,
282
]
]
}
] |
[
{
"id": "split_0_train_46341_entity",
"type": "progene_text",
"text": [
"DNA MTase"
],
"offsets": [
[
87,
96
]
],
"normalized": []
},
{
"id": "split_0_train_46342_entity",
"type": "progene_text",
"text": [
"DNA MTase"
],
"offsets": [
[
128,
137
]
],
"normalized": []
},
{
"id": "split_0_train_46343_entity",
"type": "progene_text",
"text": [
"MTase"
],
"offsets": [
[
231,
236
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28601
|
split_0_train_28601
|
[
{
"id": "split_0_train_28601_passage",
"type": "progene_text",
"text": [
"The system provides a model with which the role of DNA methylation in critical genes and DNA sequences can be investigated in glioma cells ."
],
"offsets": [
[
0,
140
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28602
|
split_0_train_28602
|
[
{
"id": "split_0_train_28602_passage",
"type": "progene_text",
"text": [
"Surface modification of polyethylene balloon catheters for local drug delivery ."
],
"offsets": [
[
0,
80
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28603
|
split_0_train_28603
|
[
{
"id": "split_0_train_28603_passage",
"type": "progene_text",
"text": [
"Local drug delivery is an attractive approach to the associated problems of percutaneous transluminal coronary angioplasty ( PTCA ) , including arterial injury ."
],
"offsets": [
[
0,
161
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28604
|
split_0_train_28604
|
[
{
"id": "split_0_train_28604_passage",
"type": "progene_text",
"text": [
"The objective of the present research was to deliver a high concentration of a potent anti - thrombin agent , argatroban ( ARG ) , to the vessel wall in order to reduce arterial injury ."
],
"offsets": [
[
0,
186
]
]
}
] |
[
{
"id": "split_0_train_46344_entity",
"type": "progene_text",
"text": [
"thrombin"
],
"offsets": [
[
93,
101
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28605
|
split_0_train_28605
|
[
{
"id": "split_0_train_28605_passage",
"type": "progene_text",
"text": [
"Local delivery was accomplished by the ionic attachment of drug particles to a modified balloon surface ."
],
"offsets": [
[
0,
105
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28606
|
split_0_train_28606
|
[
{
"id": "split_0_train_28606_passage",
"type": "progene_text",
"text": [
"Surface graft polymerization of ionic monomers to a high - density poly ( ethylene ) ( PE ) substrate was performed utilizing ultra - violet ( UV ) methods ."
],
"offsets": [
[
0,
157
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28607
|
split_0_train_28607
|
[
{
"id": "split_0_train_28607_passage",
"type": "progene_text",
"text": [
"Acrylic acid ( AAc ) and 2 ( dimethylamino ) ethyl methacrylate ( DMAEMA ) were successfully grafted onto PE surfaces ."
],
"offsets": [
[
0,
119
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28608
|
split_0_train_28608
|
[
{
"id": "split_0_train_28608_passage",
"type": "progene_text",
"text": [
"Surface grafting was verified by contact angle , X - ray photoelectron spectroscopy , and zeta potential measurements ."
],
"offsets": [
[
0,
119
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28609
|
split_0_train_28609
|
[
{
"id": "split_0_train_28609_passage",
"type": "progene_text",
"text": [
"The amount of ARG adsorbed onto the modified PE surface was highly dependent on the pH of the drug media for both anionic and cationic grafted monomers ."
],
"offsets": [
[
0,
153
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28610
|
split_0_train_28610
|
[
{
"id": "split_0_train_28610_passage",
"type": "progene_text",
"text": [
"The efficacy of local drug delivery to the arterial wall was analyzed using drug - immobilized PE balloon catheters in the rabbit common carotid artery model ."
],
"offsets": [
[
0,
159
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28611
|
split_0_train_28611
|
[
{
"id": "split_0_train_28611_passage",
"type": "progene_text",
"text": [
"High concentrations of ARG ( 280 nmol / g tissue ) were found within the ballooned arterial segment immediately after angioplasty , followed by a decrease after blood flow was restored ."
],
"offsets": [
[
0,
186
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28612
|
split_0_train_28612
|
[
{
"id": "split_0_train_28612_passage",
"type": "progene_text",
"text": [
"Functional differences between human and bovine immunodeficiency virus Tat transcription factors ."
],
"offsets": [
[
0,
98
]
]
}
] |
[
{
"id": "split_0_train_46345_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
71,
74
]
],
"normalized": []
},
{
"id": "split_0_train_46346_entity",
"type": "progene_text",
"text": [
"transcription factors"
],
"offsets": [
[
75,
96
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28613
|
split_0_train_28613
|
[
{
"id": "split_0_train_28613_passage",
"type": "progene_text",
"text": [
"Transcriptional transactivation of the human immunodeficiency virus type 1 ( HIV-1 ) long terminal repeat ( LTR ) promoter element by the essential viral Tat protein requires recruitment of positive transcription elongation factor b ( P - TEFb ) to the viral TAR RNA target ."
],
"offsets": [
[
0,
275
]
]
}
] |
[
{
"id": "split_0_train_46347_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
154,
157
]
],
"normalized": []
},
{
"id": "split_0_train_46348_entity",
"type": "progene_text",
"text": [
"positive transcription elongation factor b"
],
"offsets": [
[
190,
232
]
],
"normalized": []
},
{
"id": "split_0_train_46349_entity",
"type": "progene_text",
"text": [
"P - TEFb"
],
"offsets": [
[
235,
243
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28614
|
split_0_train_28614
|
[
{
"id": "split_0_train_28614_passage",
"type": "progene_text",
"text": [
"The recruitment of P-TEFb , which has been proposed to be necessary and sufficient for activation of viral gene expression , is mediated by the highly cooperative interaction of Tat and cyclin T1 , an essential component of P - TEFb , with the HIV-1 TAR element ."
],
"offsets": [
[
0,
263
]
]
}
] |
[
{
"id": "split_0_train_46350_entity",
"type": "progene_text",
"text": [
"P-TEFb"
],
"offsets": [
[
19,
25
]
],
"normalized": []
},
{
"id": "split_0_train_46351_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
178,
181
]
],
"normalized": []
},
{
"id": "split_0_train_46352_entity",
"type": "progene_text",
"text": [
"cyclin T1"
],
"offsets": [
[
186,
195
]
],
"normalized": []
},
{
"id": "split_0_train_46353_entity",
"type": "progene_text",
"text": [
"P - TEFb"
],
"offsets": [
[
224,
232
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28615
|
split_0_train_28615
|
[
{
"id": "split_0_train_28615_passage",
"type": "progene_text",
"text": [
"Species , such as rodents , that encode cyclin T1 variants that are unable to support TAR binding by the Tat - cyclin T1 heterodimer are also unable to support HIV-1 Tat function ."
],
"offsets": [
[
0,
180
]
]
}
] |
[
{
"id": "split_0_train_46354_entity",
"type": "progene_text",
"text": [
"cyclin T1"
],
"offsets": [
[
40,
49
]
],
"normalized": []
},
{
"id": "split_0_train_46355_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
105,
108
]
],
"normalized": []
},
{
"id": "split_0_train_46356_entity",
"type": "progene_text",
"text": [
"cyclin T1"
],
"offsets": [
[
111,
120
]
],
"normalized": []
},
{
"id": "split_0_train_46357_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
166,
169
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28616
|
split_0_train_28616
|
[
{
"id": "split_0_train_28616_passage",
"type": "progene_text",
"text": [
"In contrast , we here demonstrate that the bovine immunodeficiency virus ( BIV ) Tat protein is fully able to bind to BIV TAR both in vivo and in vitro in the absence of any cellular cofactor ."
],
"offsets": [
[
0,
193
]
]
}
] |
[
{
"id": "split_0_train_46358_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
81,
84
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28617
|
split_0_train_28617
|
[
{
"id": "split_0_train_28617_passage",
"type": "progene_text",
"text": [
"Nevertheless , BIV Tat can specifically recruit cyclin T1 to the BIV TAR element , and this recruitment is as essential for BIV Tat function as it is for HIV-1 Tat activity ."
],
"offsets": [
[
0,
174
]
]
}
] |
[
{
"id": "split_0_train_46359_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
19,
22
]
],
"normalized": []
},
{
"id": "split_0_train_46360_entity",
"type": "progene_text",
"text": [
"cyclin T1"
],
"offsets": [
[
48,
57
]
],
"normalized": []
},
{
"id": "split_0_train_46361_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
128,
131
]
],
"normalized": []
},
{
"id": "split_0_train_46362_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
160,
163
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28618
|
split_0_train_28618
|
[
{
"id": "split_0_train_28618_passage",
"type": "progene_text",
"text": [
"However , because the cyclin T1 protein does not contribute to TAR binding , BIV Tat is able to function effectively in cells from several species that do not support HIV-1 Tat function ."
],
"offsets": [
[
0,
187
]
]
}
] |
[
{
"id": "split_0_train_46363_entity",
"type": "progene_text",
"text": [
"cyclin T1"
],
"offsets": [
[
22,
31
]
],
"normalized": []
},
{
"id": "split_0_train_46364_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
81,
84
]
],
"normalized": []
},
{
"id": "split_0_train_46365_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
173,
176
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28619
|
split_0_train_28619
|
[
{
"id": "split_0_train_28619_passage",
"type": "progene_text",
"text": [
"Thus , BIV Tat , while apparently dependent on the same cellular cofactor as the Tat proteins encoded by other lentiviruses , is nevertheless unique in terms of the mechanism used to recruit the BIV Tat - cyclin T1 complex to the viral LTR promoter ."
],
"offsets": [
[
0,
250
]
]
}
] |
[
{
"id": "split_0_train_46366_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
11,
14
]
],
"normalized": []
},
{
"id": "split_0_train_46367_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
81,
84
]
],
"normalized": []
},
{
"id": "split_0_train_46368_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
199,
202
]
],
"normalized": []
},
{
"id": "split_0_train_46369_entity",
"type": "progene_text",
"text": [
"cyclin T1"
],
"offsets": [
[
205,
214
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28620
|
split_0_train_28620
|
[
{
"id": "split_0_train_28620_passage",
"type": "progene_text",
"text": [
"[ Cloning and expression of the lux - operon of Photorhabdus luminescens , strain Zm1 : nucleotide sequence of luxAB genes and basic properties of luciferase ]"
],
"offsets": [
[
0,
159
]
]
}
] |
[
{
"id": "split_0_train_46370_entity",
"type": "progene_text",
"text": [
"lux - operon"
],
"offsets": [
[
32,
44
]
],
"normalized": []
},
{
"id": "split_0_train_46371_entity",
"type": "progene_text",
"text": [
"luxAB"
],
"offsets": [
[
111,
116
]
],
"normalized": []
},
{
"id": "split_0_train_46372_entity",
"type": "progene_text",
"text": [
"luciferase"
],
"offsets": [
[
147,
157
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28621
|
split_0_train_28621
|
[
{
"id": "split_0_train_28621_passage",
"type": "progene_text",
"text": [
"A chromosomal fragment of bacteria Photorhabdus luminescence Zm1 , which contains the lux operon , was cloned into the vector pUC18 ."
],
"offsets": [
[
0,
133
]
]
}
] |
[
{
"id": "split_0_train_46373_entity",
"type": "progene_text",
"text": [
"lux operon"
],
"offsets": [
[
86,
96
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28622
|
split_0_train_28622
|
[
{
"id": "split_0_train_28622_passage",
"type": "progene_text",
"text": [
"The hybrid clone containing plasmid pXen7 with the EcoRI fragment approximately 7 - kb was shown to manifest a high level of bioluminescence ."
],
"offsets": [
[
0,
142
]
]
}
] |
[
{
"id": "split_0_train_46374_entity",
"type": "progene_text",
"text": [
"EcoRI"
],
"offsets": [
[
51,
56
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28623
|
split_0_train_28623
|
[
{
"id": "split_0_train_28623_passage",
"type": "progene_text",
"text": [
"By subcloning and restriction analysis of the EcoRI fragment , the location of luxCDABE genes relative to restriction sites was determined ."
],
"offsets": [
[
0,
140
]
]
}
] |
[
{
"id": "split_0_train_46375_entity",
"type": "progene_text",
"text": [
"EcoRI"
],
"offsets": [
[
46,
51
]
],
"normalized": []
},
{
"id": "split_0_train_46376_entity",
"type": "progene_text",
"text": [
"luxCDABE"
],
"offsets": [
[
79,
87
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28624
|
split_0_train_28624
|
[
{
"id": "split_0_train_28624_passage",
"type": "progene_text",
"text": [
"The nucleotide sequence of the DNA fragment containing the luxA and luxB genes encoding alpha - and beta - subunits of luciferase was determined ."
],
"offsets": [
[
0,
146
]
]
}
] |
[
{
"id": "split_0_train_46377_entity",
"type": "progene_text",
"text": [
"luxA"
],
"offsets": [
[
59,
63
]
],
"normalized": []
},
{
"id": "split_0_train_46378_entity",
"type": "progene_text",
"text": [
"luxB"
],
"offsets": [
[
68,
72
]
],
"normalized": []
},
{
"id": "split_0_train_46379_entity",
"type": "progene_text",
"text": [
"luciferase"
],
"offsets": [
[
119,
129
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28625
|
split_0_train_28625
|
[
{
"id": "split_0_train_28625_passage",
"type": "progene_text",
"text": [
"A comparison with the nucleotide sequences of luxAB genes in Hm and Hw strains of Ph. luminescence revealed 94.5 and 89.7 % homology , respectively ."
],
"offsets": [
[
0,
149
]
]
}
] |
[
{
"id": "split_0_train_46380_entity",
"type": "progene_text",
"text": [
"luxAB"
],
"offsets": [
[
46,
51
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28626
|
split_0_train_28626
|
[
{
"id": "split_0_train_28626_passage",
"type": "progene_text",
"text": [
"The enterobacterial repetitive intergenic sequence ( ERIC ) of 126 bp typical for Hw strains was identified in the spacer between the luxD and luxA genes ."
],
"offsets": [
[
0,
155
]
]
}
] |
[
{
"id": "split_0_train_46381_entity",
"type": "progene_text",
"text": [
"luxD"
],
"offsets": [
[
134,
138
]
],
"normalized": []
},
{
"id": "split_0_train_46382_entity",
"type": "progene_text",
"text": [
"luxA"
],
"offsets": [
[
143,
147
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28627
|
split_0_train_28627
|
[
{
"id": "split_0_train_28627_passage",
"type": "progene_text",
"text": [
"The lux operon of Zm1 is assumed to emerge through recombination between Hm and Hw strains ."
],
"offsets": [
[
0,
92
]
]
}
] |
[
{
"id": "split_0_train_46383_entity",
"type": "progene_text",
"text": [
"lux operon"
],
"offsets": [
[
4,
14
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28628
|
split_0_train_28628
|
[
{
"id": "split_0_train_28628_passage",
"type": "progene_text",
"text": [
"Luciferase of Ph. luminescence was shown to possess a high thermal stability : its activity decreased by a factor of 10 at 44 degrees C for 30 min , whereas luciferases of marine bacteria Vibrio fischeri and Vibrio harveyi were inactivated by one order of magnitude at 44 degrees C for 1 and 6 min , respectively ."
],
"offsets": [
[
0,
314
]
]
}
] |
[
{
"id": "split_0_train_46384_entity",
"type": "progene_text",
"text": [
"Luciferase"
],
"offsets": [
[
0,
10
]
],
"normalized": []
},
{
"id": "split_0_train_46385_entity",
"type": "progene_text",
"text": [
"luciferases"
],
"offsets": [
[
157,
168
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28629
|
split_0_train_28629
|
[
{
"id": "split_0_train_28629_passage",
"type": "progene_text",
"text": [
"The lux genes of Ph. luminescence are suggested for use in gene engineering and biotechnology ."
],
"offsets": [
[
0,
95
]
]
}
] |
[
{
"id": "split_0_train_46386_entity",
"type": "progene_text",
"text": [
"lux"
],
"offsets": [
[
4,
7
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28630
|
split_0_train_28630
|
[
{
"id": "split_0_train_28630_passage",
"type": "progene_text",
"text": [
"Transactivation properties of parsley proline - rich bZIP transcription factors ."
],
"offsets": [
[
0,
81
]
]
}
] |
[
{
"id": "split_0_train_46387_entity",
"type": "progene_text",
"text": [
"transcription factors"
],
"offsets": [
[
58,
79
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28631
|
split_0_train_28631
|
[
{
"id": "split_0_train_28631_passage",
"type": "progene_text",
"text": [
"Light - responsive chalcone synthase ( CHS ) gene activation requires LRUCHS , a light regulatory promoter unit including the MYB recognition element MRECHS and the ACGT - containing element ACECHS ."
],
"offsets": [
[
0,
199
]
]
}
] |
[
{
"id": "split_0_train_46388_entity",
"type": "progene_text",
"text": [
"chalcone synthase"
],
"offsets": [
[
19,
36
]
],
"normalized": []
},
{
"id": "split_0_train_46389_entity",
"type": "progene_text",
"text": [
"CHS"
],
"offsets": [
[
39,
42
]
],
"normalized": []
},
{
"id": "split_0_train_46390_entity",
"type": "progene_text",
"text": [
"MYB"
],
"offsets": [
[
126,
129
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28632
|
split_0_train_28632
|
[
{
"id": "split_0_train_28632_passage",
"type": "progene_text",
"text": [
"ACECHS is bound by the parsley basic region / leucine zipper ( bZIP ) factors CPRF1 and 4 ."
],
"offsets": [
[
0,
91
]
]
}
] |
[
{
"id": "split_0_train_46391_entity",
"type": "progene_text",
"text": [
"CPRF1 and 4"
],
"offsets": [
[
78,
89
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28633
|
split_0_train_28633
|
[
{
"id": "split_0_train_28633_passage",
"type": "progene_text",
"text": [
"Factors containing the bZIP domain exist in animals , plants and yeast , and recognize DNA sequence - specifically after formation of homo - or heterodimers ."
],
"offsets": [
[
0,
158
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28634
|
split_0_train_28634
|
[
{
"id": "split_0_train_28634_passage",
"type": "progene_text",
"text": [
"To determine the potential role of CPRFs in the regulation of CHS promoter activity , we investigated the functions of distinct CPRF domains in a homologous co - transfection system ."
],
"offsets": [
[
0,
183
]
]
}
] |
[
{
"id": "split_0_train_46392_entity",
"type": "progene_text",
"text": [
"CPRFs"
],
"offsets": [
[
35,
40
]
],
"normalized": []
},
{
"id": "split_0_train_46393_entity",
"type": "progene_text",
"text": [
"CHS"
],
"offsets": [
[
62,
65
]
],
"normalized": []
},
{
"id": "split_0_train_46394_entity",
"type": "progene_text",
"text": [
"CPRF"
],
"offsets": [
[
128,
132
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28635
|
split_0_train_28635
|
[
{
"id": "split_0_train_28635_passage",
"type": "progene_text",
"text": [
"The proline - rich domains of CPRF1 and CPRF4 activate transcription , indicating that CPRF1 and CPRF4 have transactivating properties ."
],
"offsets": [
[
0,
136
]
]
}
] |
[
{
"id": "split_0_train_46395_entity",
"type": "progene_text",
"text": [
"CPRF1"
],
"offsets": [
[
30,
35
]
],
"normalized": []
},
{
"id": "split_0_train_46396_entity",
"type": "progene_text",
"text": [
"CPRF4"
],
"offsets": [
[
40,
45
]
],
"normalized": []
},
{
"id": "split_0_train_46397_entity",
"type": "progene_text",
"text": [
"CPRF1"
],
"offsets": [
[
87,
92
]
],
"normalized": []
},
{
"id": "split_0_train_46398_entity",
"type": "progene_text",
"text": [
"CPRF4"
],
"offsets": [
[
97,
102
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28636
|
split_0_train_28636
|
[
{
"id": "split_0_train_28636_passage",
"type": "progene_text",
"text": [
"Over - expression of the CPRF1 bZIP domain caused a reduction of LRUCHS - mediated light inducibility , and point mutations throughout ACECHS affected both responsiveness to UV - containing white light and transactivation by CPRF1 : VP16 ."
],
"offsets": [
[
0,
239
]
]
}
] |
[
{
"id": "split_0_train_46399_entity",
"type": "progene_text",
"text": [
"CPRF1"
],
"offsets": [
[
25,
30
]
],
"normalized": []
},
{
"id": "split_0_train_46400_entity",
"type": "progene_text",
"text": [
"CPRF1"
],
"offsets": [
[
225,
230
]
],
"normalized": []
},
{
"id": "split_0_train_46401_entity",
"type": "progene_text",
"text": [
"VP16"
],
"offsets": [
[
233,
237
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28637
|
split_0_train_28637
|
[
{
"id": "split_0_train_28637_passage",
"type": "progene_text",
"text": [
"The data suggest that a CPRF1 - containing bZIP heterodimer interacts with ACECHS in vivo ."
],
"offsets": [
[
0,
91
]
]
}
] |
[
{
"id": "split_0_train_46402_entity",
"type": "progene_text",
"text": [
"CPRF1"
],
"offsets": [
[
24,
29
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28638
|
split_0_train_28638
|
[
{
"id": "split_0_train_28638_passage",
"type": "progene_text",
"text": [
"We discuss regulatory steps in light - induced CHS transcription that may be influenced by CPRF1 and/or related bZIP factors ."
],
"offsets": [
[
0,
126
]
]
}
] |
[
{
"id": "split_0_train_46403_entity",
"type": "progene_text",
"text": [
"CHS"
],
"offsets": [
[
47,
50
]
],
"normalized": []
},
{
"id": "split_0_train_46404_entity",
"type": "progene_text",
"text": [
"CPRF1"
],
"offsets": [
[
91,
96
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28639
|
split_0_train_28639
|
[
{
"id": "split_0_train_28639_passage",
"type": "progene_text",
"text": [
"Cloning and functional characterization of a putative sodium channel auxiliary subunit gene from the house fly ( Musca domestica ) ."
],
"offsets": [
[
0,
132
]
]
}
] |
[
{
"id": "split_0_train_46405_entity",
"type": "progene_text",
"text": [
"sodium channel"
],
"offsets": [
[
54,
68
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28640
|
split_0_train_28640
|
[
{
"id": "split_0_train_28640_passage",
"type": "progene_text",
"text": [
"The functional expression of cloned Drosophila melanogaster and house fly ( Musca domestica ) voltage - sensitive sodium channels in Xenopus oocytes is enhanced , and the inactivation kinetics of the expressed channels are accelerated , by coexpression with the tipE protein , a putative sodium channel auxiliary subunit encoded by the tipE gene of D. melanogaster ."
],
"offsets": [
[
0,
366
]
]
}
] |
[
{
"id": "split_0_train_46406_entity",
"type": "progene_text",
"text": [
"voltage - sensitive sodium"
],
"offsets": [
[
94,
120
]
],
"normalized": []
},
{
"id": "split_0_train_46407_entity",
"type": "progene_text",
"text": [
"tipE"
],
"offsets": [
[
262,
266
]
],
"normalized": []
},
{
"id": "split_0_train_46408_entity",
"type": "progene_text",
"text": [
"sodium channel"
],
"offsets": [
[
288,
302
]
],
"normalized": []
},
{
"id": "split_0_train_46409_entity",
"type": "progene_text",
"text": [
"tipE"
],
"offsets": [
[
336,
340
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28641
|
split_0_train_28641
|
[
{
"id": "split_0_train_28641_passage",
"type": "progene_text",
"text": [
"These results predict the existence of a tipE ortholog in the house fly ."
],
"offsets": [
[
0,
73
]
]
}
] |
[
{
"id": "split_0_train_46410_entity",
"type": "progene_text",
"text": [
"tipE"
],
"offsets": [
[
41,
45
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28642
|
split_0_train_28642
|
[
{
"id": "split_0_train_28642_passage",
"type": "progene_text",
"text": [
"Using a PCR - based homology probing approach , we isolated cDNA clones encoding an ortholog of tipE ( designated Vssc beta ) from adult house fly heads ."
],
"offsets": [
[
0,
154
]
]
}
] |
[
{
"id": "split_0_train_46411_entity",
"type": "progene_text",
"text": [
"tipE"
],
"offsets": [
[
96,
100
]
],
"normalized": []
},
{
"id": "split_0_train_46412_entity",
"type": "progene_text",
"text": [
"Vssc"
],
"offsets": [
[
114,
118
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28643
|
split_0_train_28643
|
[
{
"id": "split_0_train_28643_passage",
"type": "progene_text",
"text": [
"Clones comprising 3444 bp of cDNA sequence contained a 1317 bp open - reading frame encoding a 438 amino acid protein ."
],
"offsets": [
[
0,
119
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28644
|
split_0_train_28644
|
[
{
"id": "split_0_train_28644_passage",
"type": "progene_text",
"text": [
"The predicted Vssc beta protein exhibited 72 % amino acid sequence identity to the entire D. melanogaster tipE protein sequence and 97 % identity within the two hydrophobic segments identified as probable transmembrane domains ."
],
"offsets": [
[
0,
228
]
]
}
] |
[
{
"id": "split_0_train_46413_entity",
"type": "progene_text",
"text": [
"Vssc"
],
"offsets": [
[
14,
18
]
],
"normalized": []
},
{
"id": "split_0_train_46414_entity",
"type": "progene_text",
"text": [
"tipE"
],
"offsets": [
[
106,
110
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28645
|
split_0_train_28645
|
[
{
"id": "split_0_train_28645_passage",
"type": "progene_text",
"text": [
"Coexpression of Vssc beta with the house fly sodium channel alpha subunit ( Vssc1 ) in oocytes enhanced the level of sodium current expression five - fold and accelerated the rate of sodium current inactivation 2.2 - fold ."
],
"offsets": [
[
0,
223
]
]
}
] |
[
{
"id": "split_0_train_46415_entity",
"type": "progene_text",
"text": [
"Vssc"
],
"offsets": [
[
16,
20
]
],
"normalized": []
},
{
"id": "split_0_train_46416_entity",
"type": "progene_text",
"text": [
"sodium channel"
],
"offsets": [
[
45,
59
]
],
"normalized": []
},
{
"id": "split_0_train_46417_entity",
"type": "progene_text",
"text": [
"Vssc1"
],
"offsets": [
[
76,
81
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28646
|
split_0_train_28646
|
[
{
"id": "split_0_train_28646_passage",
"type": "progene_text",
"text": [
"Both of these effects were significantly larger in magnitude than the corresponding effects of the D. melanogaster tipE protein on the expression and kinetics of Vssc1 sodium channels ."
],
"offsets": [
[
0,
185
]
]
}
] |
[
{
"id": "split_0_train_46418_entity",
"type": "progene_text",
"text": [
"tipE"
],
"offsets": [
[
115,
119
]
],
"normalized": []
},
{
"id": "split_0_train_46419_entity",
"type": "progene_text",
"text": [
"Vssc1"
],
"offsets": [
[
162,
167
]
],
"normalized": []
},
{
"id": "split_0_train_46420_entity",
"type": "progene_text",
"text": [
"sodium channels"
],
"offsets": [
[
168,
183
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28647
|
split_0_train_28647
|
[
{
"id": "split_0_train_28647_passage",
"type": "progene_text",
"text": [
"These results identify a second example of a putative sodium channel auxiliary subunit from an insect having functional but not structural homology to vertebrate sodium channel beta subunits ."
],
"offsets": [
[
0,
192
]
]
}
] |
[
{
"id": "split_0_train_46421_entity",
"type": "progene_text",
"text": [
"sodium channel"
],
"offsets": [
[
54,
68
]
],
"normalized": []
},
{
"id": "split_0_train_46422_entity",
"type": "progene_text",
"text": [
"sodium channel"
],
"offsets": [
[
162,
176
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28648
|
split_0_train_28648
|
[
{
"id": "split_0_train_28648_passage",
"type": "progene_text",
"text": [
"Expression and localization of enzymes of arginine metabolism in the rat eye ."
],
"offsets": [
[
0,
78
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28649
|
split_0_train_28649
|
[
{
"id": "split_0_train_28649_passage",
"type": "progene_text",
"text": [
"PURPOSE :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28650
|
split_0_train_28650
|
[
{
"id": "split_0_train_28650_passage",
"type": "progene_text",
"text": [
"Production of NO may be regulated by argininosuccinate synthetase and argininosuccinate lyase which recycle citrulline to arginine , and by arginase which hydrolyzes arginine to urea and ornithine ."
],
"offsets": [
[
0,
198
]
]
}
] |
[
{
"id": "split_0_train_46423_entity",
"type": "progene_text",
"text": [
"argininosuccinate synthetase"
],
"offsets": [
[
37,
65
]
],
"normalized": []
},
{
"id": "split_0_train_46424_entity",
"type": "progene_text",
"text": [
"argininosuccinate lyase"
],
"offsets": [
[
70,
93
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28651
|
split_0_train_28651
|
[
{
"id": "split_0_train_28651_passage",
"type": "progene_text",
"text": [
"Expression of these and related enzymes in rat eye was studied ."
],
"offsets": [
[
0,
64
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28652
|
split_0_train_28652
|
[
{
"id": "split_0_train_28652_passage",
"type": "progene_text",
"text": [
"METHODS :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28653
|
split_0_train_28653
|
[
{
"id": "split_0_train_28653_passage",
"type": "progene_text",
"text": [
"mRNAs for the enzymes were analyzed by reverse transcription - polymerase chain reaction ( RT - PCR ) ."
],
"offsets": [
[
0,
103
]
]
}
] |
[
{
"id": "split_0_train_46425_entity",
"type": "progene_text",
"text": [
"polymerase"
],
"offsets": [
[
63,
73
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28654
|
split_0_train_28654
|
[
{
"id": "split_0_train_28654_passage",
"type": "progene_text",
"text": [
"Localization of the enzyme proteins and mRNAs was analyzed by immunohistochemistry and in situ hybridization , respectively ."
],
"offsets": [
[
0,
125
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28655
|
split_0_train_28655
|
[
{
"id": "split_0_train_28655_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28656
|
split_0_train_28656
|
[
{
"id": "split_0_train_28656_passage",
"type": "progene_text",
"text": [
"In RT - PCR analysis , arginase II ( nonhepatic type ) mRNA was detected in retina and weakly in cornea , whereas arginase I ( hepatic type ) mRNA was not detected in any area ."
],
"offsets": [
[
0,
177
]
]
}
] |
[
{
"id": "split_0_train_46426_entity",
"type": "progene_text",
"text": [
"arginase II"
],
"offsets": [
[
23,
34
]
],
"normalized": []
},
{
"id": "split_0_train_46427_entity",
"type": "progene_text",
"text": [
"arginase I"
],
"offsets": [
[
114,
124
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28657
|
split_0_train_28657
|
[
{
"id": "split_0_train_28657_passage",
"type": "progene_text",
"text": [
"mRNAs for argininosuccinate synthetase , argininosuccinate lyase , ornithine aminotransferase and ornithine decarboxylase were present in all areas ."
],
"offsets": [
[
0,
149
]
]
}
] |
[
{
"id": "split_0_train_46428_entity",
"type": "progene_text",
"text": [
"argininosuccinate synthetase"
],
"offsets": [
[
10,
38
]
],
"normalized": []
},
{
"id": "split_0_train_46429_entity",
"type": "progene_text",
"text": [
"argininosuccinate lyase"
],
"offsets": [
[
41,
64
]
],
"normalized": []
},
{
"id": "split_0_train_46430_entity",
"type": "progene_text",
"text": [
"ornithine aminotransferase"
],
"offsets": [
[
67,
93
]
],
"normalized": []
},
{
"id": "split_0_train_46431_entity",
"type": "progene_text",
"text": [
"ornithine decarboxylase"
],
"offsets": [
[
98,
121
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28658
|
split_0_train_28658
|
[
{
"id": "split_0_train_28658_passage",
"type": "progene_text",
"text": [
"In immunohistochemical analysis , arginase II was stained in cornea , epithelium of iris and ciliary process , inner part of neural retina and retinal pigment epithelium ."
],
"offsets": [
[
0,
171
]
]
}
] |
[
{
"id": "split_0_train_46432_entity",
"type": "progene_text",
"text": [
"arginase II"
],
"offsets": [
[
34,
45
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28659
|
split_0_train_28659
|
[
{
"id": "split_0_train_28659_passage",
"type": "progene_text",
"text": [
"Immunostaining of ornithine aminotransferase resembled that of arginase II ."
],
"offsets": [
[
0,
76
]
]
}
] |
[
{
"id": "split_0_train_46433_entity",
"type": "progene_text",
"text": [
"ornithine aminotransferase"
],
"offsets": [
[
18,
44
]
],
"normalized": []
},
{
"id": "split_0_train_46434_entity",
"type": "progene_text",
"text": [
"arginase II"
],
"offsets": [
[
63,
74
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28660
|
split_0_train_28660
|
[
{
"id": "split_0_train_28660_passage",
"type": "progene_text",
"text": [
"In in situ hybridization , arginase II and ornithine aminotransferase mRNAs were located much as seen with the enzyme proteins ."
],
"offsets": [
[
0,
128
]
]
}
] |
[
{
"id": "split_0_train_46435_entity",
"type": "progene_text",
"text": [
"arginase II"
],
"offsets": [
[
27,
38
]
],
"normalized": []
},
{
"id": "split_0_train_46436_entity",
"type": "progene_text",
"text": [
"ornithine aminotransferase"
],
"offsets": [
[
43,
69
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28661
|
split_0_train_28661
|
[
{
"id": "split_0_train_28661_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28662
|
split_0_train_28662
|
[
{
"id": "split_0_train_28662_passage",
"type": "progene_text",
"text": [
"These results indicate that arginine recycling activity from citrulline is present widely in ocular tissues , whereas expression of arginase II differs among the tissues ."
],
"offsets": [
[
0,
171
]
]
}
] |
[
{
"id": "split_0_train_46437_entity",
"type": "progene_text",
"text": [
"arginase II"
],
"offsets": [
[
132,
143
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28663
|
split_0_train_28663
|
[
{
"id": "split_0_train_28663_passage",
"type": "progene_text",
"text": [
"We suggest that NO production may be regulated by these enzymes in the cells where NO synthase is colocalized ."
],
"offsets": [
[
0,
111
]
]
}
] |
[
{
"id": "split_0_train_46438_entity",
"type": "progene_text",
"text": [
"NO synthase"
],
"offsets": [
[
83,
94
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28664
|
split_0_train_28664
|
[
{
"id": "split_0_train_28664_passage",
"type": "progene_text",
"text": [
"Colocalization of arginase II and ornithine aminotransferase suggests a role for arginase II in collagen synthesis in the eye ."
],
"offsets": [
[
0,
127
]
]
}
] |
[
{
"id": "split_0_train_46439_entity",
"type": "progene_text",
"text": [
"arginase II"
],
"offsets": [
[
18,
29
]
],
"normalized": []
},
{
"id": "split_0_train_46440_entity",
"type": "progene_text",
"text": [
"ornithine aminotransferase"
],
"offsets": [
[
34,
60
]
],
"normalized": []
},
{
"id": "split_0_train_46441_entity",
"type": "progene_text",
"text": [
"arginase II"
],
"offsets": [
[
81,
92
]
],
"normalized": []
},
{
"id": "split_0_train_46442_entity",
"type": "progene_text",
"text": [
"collagen"
],
"offsets": [
[
96,
104
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28665
|
split_0_train_28665
|
[
{
"id": "split_0_train_28665_passage",
"type": "progene_text",
"text": [
"Interactions between the soluble domain I of nicotinamide nucleotide transhydrogenase from Rhodospirillum rubrum and transhydrogenase from Escherichia coli ."
],
"offsets": [
[
0,
157
]
]
}
] |
[
{
"id": "split_0_train_46443_entity",
"type": "progene_text",
"text": [
"nicotinamide nucleotide transhydrogenase"
],
"offsets": [
[
45,
85
]
],
"normalized": []
},
{
"id": "split_0_train_46444_entity",
"type": "progene_text",
"text": [
"transhydrogenase"
],
"offsets": [
[
117,
133
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28666
|
split_0_train_28666
|
[
{
"id": "split_0_train_28666_passage",
"type": "progene_text",
"text": [
"Effects on catalytic and H + - pumping activities ."
],
"offsets": [
[
0,
51
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28667
|
split_0_train_28667
|
[
{
"id": "split_0_train_28667_passage",
"type": "progene_text",
"text": [
"Nicotinamide nucleotide transhydrogenase from Escherichia coli is composed of two subunits , the alpha and the beta subunits , each of which contains a hydrophilic domain , domain I and III , respectively , as well as several transmembrane helices , collectively denoted domain II ."
],
"offsets": [
[
0,
282
]
]
}
] |
[
{
"id": "split_0_train_46445_entity",
"type": "progene_text",
"text": [
"Nicotinamide nucleotide transhydrogenase"
],
"offsets": [
[
0,
40
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28668
|
split_0_train_28668
|
[
{
"id": "split_0_train_28668_passage",
"type": "progene_text",
"text": [
"The interactions between domain I from Rhodospirillum rubrum ( rrI ) and the intact or the protease - treated enzyme from E. coli was investigated using the separately expressed and purified domain I from R. rubrum , and His - tagged intact and trypsin - treated E. coli transhydrogenase ."
],
"offsets": [
[
0,
289
]
]
}
] |
[
{
"id": "split_0_train_46446_entity",
"type": "progene_text",
"text": [
"protease"
],
"offsets": [
[
91,
99
]
],
"normalized": []
},
{
"id": "split_0_train_46447_entity",
"type": "progene_text",
"text": [
"trypsin"
],
"offsets": [
[
245,
252
]
],
"normalized": []
},
{
"id": "split_0_train_46448_entity",
"type": "progene_text",
"text": [
"transhydrogenase"
],
"offsets": [
[
271,
287
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28669
|
split_0_train_28669
|
[
{
"id": "split_0_train_28669_passage",
"type": "progene_text",
"text": [
"Despite harsh treatments with , e.g. detergents and denaturing agents , the alpha and beta subunits remained tightly associated ."
],
"offsets": [
[
0,
129
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28670
|
split_0_train_28670
|
[
{
"id": "split_0_train_28670_passage",
"type": "progene_text",
"text": [
"A monoclonal antibody directed towards the alpha subunit was strongly inhibitory , an effect that was relieved by added rrI ."
],
"offsets": [
[
0,
125
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28671
|
split_0_train_28671
|
[
{
"id": "split_0_train_28671_passage",
"type": "progene_text",
"text": [
"In addition , rrI also reactivated the trypsin - digested E. coli enzyme in which domain I had been partly removed ."
],
"offsets": [
[
0,
116
]
]
}
] |
[
{
"id": "split_0_train_46449_entity",
"type": "progene_text",
"text": [
"trypsin"
],
"offsets": [
[
39,
46
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28672
|
split_0_train_28672
|
[
{
"id": "split_0_train_28672_passage",
"type": "progene_text",
"text": [
"This suggests that the hydrophilic domains I and III are not in permanent contact but are mobile during catalysis while being anchored to domain II ."
],
"offsets": [
[
0,
149
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28673
|
split_0_train_28673
|
[
{
"id": "split_0_train_28673_passage",
"type": "progene_text",
"text": [
"Replacement of domain I of intact , as well as trypsin - digested , E. coli transhydrogenase with rrI resulted in a markedly different pH dependence of the cyclic reduction of 3 - acetyl - pyridine - NAD + by NADH in the presence of NADP ( H ) , suggesting that the protonation of one or more protonable groups in domain I is controlling this reaction ."
],
"offsets": [
[
0,
353
]
]
}
] |
[
{
"id": "split_0_train_46450_entity",
"type": "progene_text",
"text": [
"trypsin"
],
"offsets": [
[
47,
54
]
],
"normalized": []
},
{
"id": "split_0_train_46451_entity",
"type": "progene_text",
"text": [
"transhydrogenase"
],
"offsets": [
[
76,
92
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28674
|
split_0_train_28674
|
[
{
"id": "split_0_train_28674_passage",
"type": "progene_text",
"text": [
"The reverse reaction and proton pumping showed a less pronounced change in pH dependence , demonstrating the regulatory role of domain II in these reactions ."
],
"offsets": [
[
0,
158
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28675
|
split_0_train_28675
|
[
{
"id": "split_0_train_28675_passage",
"type": "progene_text",
"text": [
"Apg13p and Vac8p are part of a complex of phosphoproteins that are required for cytoplasm to vacuole targeting ."
],
"offsets": [
[
0,
112
]
]
}
] |
[
{
"id": "split_0_train_46452_entity",
"type": "progene_text",
"text": [
"Apg13p"
],
"offsets": [
[
0,
6
]
],
"normalized": []
},
{
"id": "split_0_train_46453_entity",
"type": "progene_text",
"text": [
"Vac8p"
],
"offsets": [
[
11,
16
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28676
|
split_0_train_28676
|
[
{
"id": "split_0_train_28676_passage",
"type": "progene_text",
"text": [
"We have been studying protein components that function in the cytoplasm to vacuole targeting ( Cvt ) pathway and the overlapping process of macroautophagy ."
],
"offsets": [
[
0,
156
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28677
|
split_0_train_28677
|
[
{
"id": "split_0_train_28677_passage",
"type": "progene_text",
"text": [
"The Vac8 and Apg13 proteins are required for the import of aminopeptidase I ( API ) through the Cvt pathway ."
],
"offsets": [
[
0,
109
]
]
}
] |
[
{
"id": "split_0_train_46454_entity",
"type": "progene_text",
"text": [
"Vac8"
],
"offsets": [
[
4,
8
]
],
"normalized": []
},
{
"id": "split_0_train_46455_entity",
"type": "progene_text",
"text": [
"Apg13"
],
"offsets": [
[
13,
18
]
],
"normalized": []
},
{
"id": "split_0_train_46456_entity",
"type": "progene_text",
"text": [
"aminopeptidase I"
],
"offsets": [
[
59,
75
]
],
"normalized": []
},
{
"id": "split_0_train_46457_entity",
"type": "progene_text",
"text": [
"API"
],
"offsets": [
[
78,
81
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28678
|
split_0_train_28678
|
[
{
"id": "split_0_train_28678_passage",
"type": "progene_text",
"text": [
"We have identified a protein - protein interaction between Vac8p and Apg13p by both two - hybrid and co - immunoprecipitation analysis ."
],
"offsets": [
[
0,
136
]
]
}
] |
[
{
"id": "split_0_train_46458_entity",
"type": "progene_text",
"text": [
"Vac8p"
],
"offsets": [
[
59,
64
]
],
"normalized": []
},
{
"id": "split_0_train_46459_entity",
"type": "progene_text",
"text": [
"Apg13p"
],
"offsets": [
[
69,
75
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28679
|
split_0_train_28679
|
[
{
"id": "split_0_train_28679_passage",
"type": "progene_text",
"text": [
"Subcellular fractionation of API indicates that Vac8p and Apg13p are involved in the vesicle formation step of the Cvt pathway ."
],
"offsets": [
[
0,
128
]
]
}
] |
[
{
"id": "split_0_train_46460_entity",
"type": "progene_text",
"text": [
"API"
],
"offsets": [
[
29,
32
]
],
"normalized": []
},
{
"id": "split_0_train_46461_entity",
"type": "progene_text",
"text": [
"Vac8p"
],
"offsets": [
[
48,
53
]
],
"normalized": []
},
{
"id": "split_0_train_46462_entity",
"type": "progene_text",
"text": [
"Apg13p"
],
"offsets": [
[
58,
64
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28680
|
split_0_train_28680
|
[
{
"id": "split_0_train_28680_passage",
"type": "progene_text",
"text": [
"Kinetic analysis of the Cvt pathway and autophagy indicates that , although Vac8p is essential for Cvt transport , it is less important for autophagy ."
],
"offsets": [
[
0,
151
]
]
}
] |
[
{
"id": "split_0_train_46463_entity",
"type": "progene_text",
"text": [
"Vac8p"
],
"offsets": [
[
76,
81
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28681
|
split_0_train_28681
|
[
{
"id": "split_0_train_28681_passage",
"type": "progene_text",
"text": [
"In vivo phosphorylation experiments demonstrate that both Vac8p and Apg13p are phosphorylated proteins , and Apg13p phosphorylation is regulated by changing nutrient conditions ."
],
"offsets": [
[
0,
178
]
]
}
] |
[
{
"id": "split_0_train_46464_entity",
"type": "progene_text",
"text": [
"Vac8p"
],
"offsets": [
[
58,
63
]
],
"normalized": []
},
{
"id": "split_0_train_46465_entity",
"type": "progene_text",
"text": [
"Apg13p"
],
"offsets": [
[
68,
74
]
],
"normalized": []
},
{
"id": "split_0_train_46466_entity",
"type": "progene_text",
"text": [
"Apg13p"
],
"offsets": [
[
109,
115
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28682
|
split_0_train_28682
|
[
{
"id": "split_0_train_28682_passage",
"type": "progene_text",
"text": [
"Although Apg13p interacts with the serine / threonine kinase Apg1p , this protein is not required for phosphorylation of either Vac8p or Apg13p ."
],
"offsets": [
[
0,
145
]
]
}
] |
[
{
"id": "split_0_train_46467_entity",
"type": "progene_text",
"text": [
"Apg13p"
],
"offsets": [
[
9,
15
]
],
"normalized": []
},
{
"id": "split_0_train_46468_entity",
"type": "progene_text",
"text": [
"serine / threonine kinase"
],
"offsets": [
[
35,
60
]
],
"normalized": []
},
{
"id": "split_0_train_46469_entity",
"type": "progene_text",
"text": [
"Apg1p"
],
"offsets": [
[
61,
66
]
],
"normalized": []
},
{
"id": "split_0_train_46470_entity",
"type": "progene_text",
"text": [
"Vac8p"
],
"offsets": [
[
128,
133
]
],
"normalized": []
},
{
"id": "split_0_train_46471_entity",
"type": "progene_text",
"text": [
"Apg13p"
],
"offsets": [
[
137,
143
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28683
|
split_0_train_28683
|
[
{
"id": "split_0_train_28683_passage",
"type": "progene_text",
"text": [
"Subcellular fractionation experiments indicate that Apg13p and a fraction of Apg1p are membrane - associated ."
],
"offsets": [
[
0,
110
]
]
}
] |
[
{
"id": "split_0_train_46472_entity",
"type": "progene_text",
"text": [
"Apg13p"
],
"offsets": [
[
52,
58
]
],
"normalized": []
},
{
"id": "split_0_train_46473_entity",
"type": "progene_text",
"text": [
"Apg1p"
],
"offsets": [
[
77,
82
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28684
|
split_0_train_28684
|
[
{
"id": "split_0_train_28684_passage",
"type": "progene_text",
"text": [
"Vac8p and Apg13p may be part of a larger protein complex that includes Apg1p and additional interacting proteins ."
],
"offsets": [
[
0,
114
]
]
}
] |
[
{
"id": "split_0_train_46474_entity",
"type": "progene_text",
"text": [
"Vac8p"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "split_0_train_46475_entity",
"type": "progene_text",
"text": [
"Apg13p"
],
"offsets": [
[
10,
16
]
],
"normalized": []
},
{
"id": "split_0_train_46476_entity",
"type": "progene_text",
"text": [
"Apg1p"
],
"offsets": [
[
71,
76
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28685
|
split_0_train_28685
|
[
{
"id": "split_0_train_28685_passage",
"type": "progene_text",
"text": [
"Together , these components may form a protein complex that regulates the conversion between Cvt transport and autophagy in response to changing nutrient conditions ."
],
"offsets": [
[
0,
166
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28686
|
split_0_train_28686
|
[
{
"id": "split_0_train_28686_passage",
"type": "progene_text",
"text": [
"Amino - and carboxy - terminal PEST domains mediate gastrin stabilization of rat L-histidine decarboxylase isoforms ."
],
"offsets": [
[
0,
117
]
]
}
] |
[
{
"id": "split_0_train_46477_entity",
"type": "progene_text",
"text": [
"gastrin"
],
"offsets": [
[
52,
59
]
],
"normalized": []
},
{
"id": "split_0_train_46478_entity",
"type": "progene_text",
"text": [
"L-histidine decarboxylase"
],
"offsets": [
[
81,
106
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28687
|
split_0_train_28687
|
[
{
"id": "split_0_train_28687_passage",
"type": "progene_text",
"text": [
"Control of enzymatic function by peptide hormones can occur at a number of different levels and can involve diverse pathways that regulate cleavage , intracellular trafficking , and protein degradation ."
],
"offsets": [
[
0,
203
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28688
|
split_0_train_28688
|
[
{
"id": "split_0_train_28688_passage",
"type": "progene_text",
"text": [
"Gastrin is a peptide hormone that binds to the cholecystokinin B-gastrin receptor and regulates the activity of L-histidine decarboxylase ( HDC ) , the enzyme that produces histamine ."
],
"offsets": [
[
0,
184
]
]
}
] |
[
{
"id": "split_0_train_46479_entity",
"type": "progene_text",
"text": [
"Gastrin"
],
"offsets": [
[
0,
7
]
],
"normalized": []
},
{
"id": "split_0_train_46480_entity",
"type": "progene_text",
"text": [
"peptide hormone"
],
"offsets": [
[
13,
28
]
],
"normalized": []
},
{
"id": "split_0_train_46481_entity",
"type": "progene_text",
"text": [
"cholecystokinin B-gastrin receptor"
],
"offsets": [
[
47,
81
]
],
"normalized": []
},
{
"id": "split_0_train_46482_entity",
"type": "progene_text",
"text": [
"L-histidine decarboxylase"
],
"offsets": [
[
112,
137
]
],
"normalized": []
},
{
"id": "split_0_train_46483_entity",
"type": "progene_text",
"text": [
"HDC"
],
"offsets": [
[
140,
143
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28689
|
split_0_train_28689
|
[
{
"id": "split_0_train_28689_passage",
"type": "progene_text",
"text": [
"Here we show that gastrin can increase the steady - state levels of at least six HDC isoforms without affecting HDC mRNA levels ."
],
"offsets": [
[
0,
129
]
]
}
] |
[
{
"id": "split_0_train_46484_entity",
"type": "progene_text",
"text": [
"gastrin"
],
"offsets": [
[
18,
25
]
],
"normalized": []
},
{
"id": "split_0_train_46485_entity",
"type": "progene_text",
"text": [
"HDC"
],
"offsets": [
[
81,
84
]
],
"normalized": []
},
{
"id": "split_0_train_46486_entity",
"type": "progene_text",
"text": [
"HDC"
],
"offsets": [
[
112,
115
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28690
|
split_0_train_28690
|
[
{
"id": "split_0_train_28690_passage",
"type": "progene_text",
"text": [
"Pulse - chase experiments indicated that HDC isoforms are rapidly degraded and that gastrin - dependent increases are due to enhanced isoform stability ."
],
"offsets": [
[
0,
153
]
]
}
] |
[
{
"id": "split_0_train_46487_entity",
"type": "progene_text",
"text": [
"HDC"
],
"offsets": [
[
41,
44
]
],
"normalized": []
},
{
"id": "split_0_train_46488_entity",
"type": "progene_text",
"text": [
"gastrin"
],
"offsets": [
[
84,
91
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28691
|
split_0_train_28691
|
[
{
"id": "split_0_train_28691_passage",
"type": "progene_text",
"text": [
"Deletion analysis identified two PEST domains ( PEST1 and PEST2 ) and an intracellular targeting domain ( ER2 ) which regulate HDC protein expression levels ."
],
"offsets": [
[
0,
158
]
]
}
] |
[
{
"id": "split_0_train_46489_entity",
"type": "progene_text",
"text": [
"HDC"
],
"offsets": [
[
127,
130
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28692
|
split_0_train_28692
|
[
{
"id": "split_0_train_28692_passage",
"type": "progene_text",
"text": [
"Experiments with PEST domain fusion proteins demonstrated that PEST1 and PEST2 are strong and portable degradation - promoting elements which are positively regulated by both gastrin stimulation and proteasome inhibition ."
],
"offsets": [
[
0,
222
]
]
}
] |
[
{
"id": "split_0_train_46490_entity",
"type": "progene_text",
"text": [
"gastrin"
],
"offsets": [
[
175,
182
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28693
|
split_0_train_28693
|
[
{
"id": "split_0_train_28693_passage",
"type": "progene_text",
"text": [
"A chimeric protein containing the PEST domain of ornithine decarboxylase was similarly affected , indicating that gastrin can regulate the stability of other PEST domain - containing proteins and does so independently of antizyme / antizyme inhibitor regulation ."
],
"offsets": [
[
0,
263
]
]
}
] |
[
{
"id": "split_0_train_46491_entity",
"type": "progene_text",
"text": [
"ornithine decarboxylase"
],
"offsets": [
[
49,
72
]
],
"normalized": []
},
{
"id": "split_0_train_46492_entity",
"type": "progene_text",
"text": [
"gastrin"
],
"offsets": [
[
114,
121
]
],
"normalized": []
},
{
"id": "split_0_train_46493_entity",
"type": "progene_text",
"text": [
"antizyme"
],
"offsets": [
[
221,
229
]
],
"normalized": []
},
{
"id": "split_0_train_46494_entity",
"type": "progene_text",
"text": [
"antizyme inhibitor"
],
"offsets": [
[
232,
250
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28694
|
split_0_train_28694
|
[
{
"id": "split_0_train_28694_passage",
"type": "progene_text",
"text": [
"At the same time , endoplasmic reticulum localization of a fluorescent chimera containing the ER2 domain of HDC was unaltered by gastrin stimulation ."
],
"offsets": [
[
0,
150
]
]
}
] |
[
{
"id": "split_0_train_46495_entity",
"type": "progene_text",
"text": [
"HDC"
],
"offsets": [
[
108,
111
]
],
"normalized": []
},
{
"id": "split_0_train_46496_entity",
"type": "progene_text",
"text": [
"gastrin"
],
"offsets": [
[
129,
136
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28695
|
split_0_train_28695
|
[
{
"id": "split_0_train_28695_passage",
"type": "progene_text",
"text": [
"We conclude that gastrin stabilization of HDC isoforms is dependent upon two transferable and sequentially unrelated PEST domains that regulate degradation ."
],
"offsets": [
[
0,
157
]
]
}
] |
[
{
"id": "split_0_train_46497_entity",
"type": "progene_text",
"text": [
"gastrin"
],
"offsets": [
[
17,
24
]
],
"normalized": []
},
{
"id": "split_0_train_46498_entity",
"type": "progene_text",
"text": [
"HDC"
],
"offsets": [
[
42,
45
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28696
|
split_0_train_28696
|
[
{
"id": "split_0_train_28696_passage",
"type": "progene_text",
"text": [
"These experiments revealed a novel regulatory mechanism by which a peptide hormone such as gastrin can disrupt the degradation function of multiple PEST - domain - containing proteins ."
],
"offsets": [
[
0,
185
]
]
}
] |
[
{
"id": "split_0_train_46499_entity",
"type": "progene_text",
"text": [
"gastrin"
],
"offsets": [
[
91,
98
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28697
|
split_0_train_28697
|
[
{
"id": "split_0_train_28697_passage",
"type": "progene_text",
"text": [
"Identification and functional characterization of human soluble epoxide hydrolase genetic polymorphisms ."
],
"offsets": [
[
0,
105
]
]
}
] |
[
{
"id": "split_0_train_46500_entity",
"type": "progene_text",
"text": [
"soluble epoxide hydrolase"
],
"offsets": [
[
56,
81
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28698
|
split_0_train_28698
|
[
{
"id": "split_0_train_28698_passage",
"type": "progene_text",
"text": [
"Human soluble epoxide hydrolase ( sEH ) , an enzyme directing the functional disposition of a variety of endogenous and xenobiotic - derived chemical epoxides , was characterized at the genomic level for interindividual variation capable of impacting function ."
],
"offsets": [
[
0,
261
]
]
}
] |
[
{
"id": "split_0_train_46501_entity",
"type": "progene_text",
"text": [
"soluble epoxide hydrolase"
],
"offsets": [
[
6,
31
]
],
"normalized": []
},
{
"id": "split_0_train_46502_entity",
"type": "progene_text",
"text": [
"sEH"
],
"offsets": [
[
34,
37
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28699
|
split_0_train_28699
|
[
{
"id": "split_0_train_28699_passage",
"type": "progene_text",
"text": [
"RNA was isolated from 25 human liver samples and used to generate full - length copies of soluble epoxide hydrolase cDNA ."
],
"offsets": [
[
0,
122
]
]
}
] |
[
{
"id": "split_0_train_46503_entity",
"type": "progene_text",
"text": [
"soluble epoxide hydrolase"
],
"offsets": [
[
90,
115
]
],
"normalized": []
}
] |
[] |
[] |
[] |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.