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stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
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|---|---|---|---|---|---|---|
split_0_train_28800
|
split_0_train_28800
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[
{
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"text": [
"ykuD was transcribed by SigK RNA polymerase from T(4) of sporulation ."
],
"offsets": [
[
0,
70
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]
}
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{
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0,
4
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24,
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"text": [
"RNA polymerase"
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"offsets": [
[
29,
43
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"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28801
|
split_0_train_28801
|
[
{
"id": "split_0_train_28801_passage",
"type": "progene_text",
"text": [
"Both SigK and GerE were essential for ykvP expression , and this gene was transcribed from T(5) of sporulation ."
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"offsets": [
[
0,
112
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}
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{
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5,
9
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14,
18
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"type": "progene_text",
"text": [
"ykvP"
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"offsets": [
[
38,
42
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28802
|
split_0_train_28802
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[
{
"id": "split_0_train_28802_passage",
"type": "progene_text",
"text": [
"Inactivation of these genes by insertion of an erythromycin resistance gene did not affect vegetative growth , spore resistance to heat , chloroform , and lysozyme , or spore germination in the presence of L-alanine or in a mixture of L-asparagine , D-glucose , D-fructose , and potassium chloride ."
],
"offsets": [
[
0,
299
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28803
|
split_0_train_28803
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[
{
"id": "split_0_train_28803_passage",
"type": "progene_text",
"text": [
"The His tag fusions of YdhD , YkuD , and YkvP downstream of their natural promoter regions were introduced into a multicopy plasmid ."
],
"offsets": [
[
0,
133
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]
}
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{
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23,
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30,
34
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"type": "progene_text",
"text": [
"YkvP"
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"offsets": [
[
41,
45
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"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28804
|
split_0_train_28804
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[
{
"id": "split_0_train_28804_passage",
"type": "progene_text",
"text": [
"These fusion proteins were produced during sporulation in B. subtilis transformants and were detected in mature spores , indicating that YdhD , YkuD , and YkvP are all proteins intrinsic to spores ."
],
"offsets": [
[
0,
198
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}
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{
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137,
141
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{
"id": "split_0_train_46719_entity",
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"YkuD"
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144,
148
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{
"id": "split_0_train_46720_entity",
"type": "progene_text",
"text": [
"YkvP"
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"offsets": [
[
155,
159
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28805
|
split_0_train_28805
|
[
{
"id": "split_0_train_28805_passage",
"type": "progene_text",
"text": [
"Excessive YkuD and YkvP in the sporulating cells did not affect spore resistance or germination ."
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"offsets": [
[
0,
97
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}
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{
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"YkuD"
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10,
14
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{
"id": "split_0_train_46722_entity",
"type": "progene_text",
"text": [
"YkvP"
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"offsets": [
[
19,
23
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"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28806
|
split_0_train_28806
|
[
{
"id": "split_0_train_28806_passage",
"type": "progene_text",
"text": [
"The cells producing excessive YdhD also did not show impaired spore resistance , but their germination properties were changed : the spores revealed reduced response to L-alanine and some of them germinated even without germinants ."
],
"offsets": [
[
0,
232
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]
}
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{
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"type": "progene_text",
"text": [
"YdhD"
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"offsets": [
[
30,
34
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28807
|
split_0_train_28807
|
[
{
"id": "split_0_train_28807_passage",
"type": "progene_text",
"text": [
"Escherichia coli b-lactamase , whose signal sequence had been genetically replaced by the cell wall binding motif of YaaH , was produced in sporulating cells , and Western blot analysis indicated that the fused protein was assembled into spores ."
],
"offsets": [
[
0,
246
]
]
}
] |
[
{
"id": "split_0_train_46724_entity",
"type": "progene_text",
"text": [
"b-lactamase"
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17,
28
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{
"id": "split_0_train_46725_entity",
"type": "progene_text",
"text": [
"YaaH"
],
"offsets": [
[
117,
121
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28808
|
split_0_train_28808
|
[
{
"id": "split_0_train_28808_passage",
"type": "progene_text",
"text": [
"We speculate that the conserved motif functions as a kind of signal sequence involved in assembly of these proteins on forespores ."
],
"offsets": [
[
0,
131
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28809
|
split_0_train_28809
|
[
{
"id": "split_0_train_28809_passage",
"type": "progene_text",
"text": [
"Cytokines and osteolysis around total hip prostheses ."
],
"offsets": [
[
0,
54
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]
}
] |
[
{
"id": "split_0_train_46726_entity",
"type": "progene_text",
"text": [
"Cytokines"
],
"offsets": [
[
0,
9
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28810
|
split_0_train_28810
|
[
{
"id": "split_0_train_28810_passage",
"type": "progene_text",
"text": [
"The aim of this work is to assess the correlation between the osteolysis around the prosthesis and the presence of cytokines favouring inflammation in the tissues at the interface between loosened prosthesis and bone ."
],
"offsets": [
[
0,
218
]
]
}
] |
[
{
"id": "split_0_train_46727_entity",
"type": "progene_text",
"text": [
"cytokines"
],
"offsets": [
[
115,
124
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28811
|
split_0_train_28811
|
[
{
"id": "split_0_train_28811_passage",
"type": "progene_text",
"text": [
"In this study , twenty - nine patients that underwent revision surgery were examined ."
],
"offsets": [
[
0,
86
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28812
|
split_0_train_28812
|
[
{
"id": "split_0_train_28812_passage",
"type": "progene_text",
"text": [
"Bioptic samples were collected at the interface between bone and implant both at the stem and socket level ."
],
"offsets": [
[
0,
108
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28813
|
split_0_train_28813
|
[
{
"id": "split_0_train_28813_passage",
"type": "progene_text",
"text": [
"Semiquantitative immunohistochemistry was performed to detect interleukin 1 alpha , interleukin 1 beta , interleukin 6 and tumour necrosis factor , cytokines that directly cause bone resorption and indirectly induce synthesis of other bone resorbing cytokines ."
],
"offsets": [
[
0,
261
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]
}
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{
"id": "split_0_train_46728_entity",
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62,
81
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{
"id": "split_0_train_46729_entity",
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84,
102
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{
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"interleukin 6"
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105,
118
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{
"id": "split_0_train_46731_entity",
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"tumour necrosis factor"
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123,
145
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{
"id": "split_0_train_46732_entity",
"type": "progene_text",
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"cytokines"
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148,
157
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{
"id": "split_0_train_46733_entity",
"type": "progene_text",
"text": [
"cytokines"
],
"offsets": [
[
250,
259
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28814
|
split_0_train_28814
|
[
{
"id": "split_0_train_28814_passage",
"type": "progene_text",
"text": [
"Wear particles were identified and quantified by light microscopy ."
],
"offsets": [
[
0,
67
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28815
|
split_0_train_28815
|
[
{
"id": "split_0_train_28815_passage",
"type": "progene_text",
"text": [
"Radiographic evidence for osteolysis was scored by the Engh and Bobyn score ."
],
"offsets": [
[
0,
77
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28816
|
split_0_train_28816
|
[
{
"id": "split_0_train_28816_passage",
"type": "progene_text",
"text": [
"In tissues collected at the interface , the percentage of cells positive to IL1 , IL6 and particularly to TNF increased in relation to the tissues collected at the interface with stable components ."
],
"offsets": [
[
0,
198
]
]
}
] |
[
{
"id": "split_0_train_46734_entity",
"type": "progene_text",
"text": [
"IL1"
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[
76,
79
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],
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},
{
"id": "split_0_train_46735_entity",
"type": "progene_text",
"text": [
"IL6"
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82,
85
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{
"id": "split_0_train_46736_entity",
"type": "progene_text",
"text": [
"TNF"
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"offsets": [
[
106,
109
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28817
|
split_0_train_28817
|
[
{
"id": "split_0_train_28817_passage",
"type": "progene_text",
"text": [
"The cells occurring in the new capsule do not secrete cytokines in quantities that can be related to severity of wear ."
],
"offsets": [
[
0,
119
]
]
}
] |
[
{
"id": "split_0_train_46737_entity",
"type": "progene_text",
"text": [
"cytokines"
],
"offsets": [
[
54,
63
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28818
|
split_0_train_28818
|
[
{
"id": "split_0_train_28818_passage",
"type": "progene_text",
"text": [
"Cemented prostheses showed higher incidence of severe osteolysis , and higher levels of cytokines ."
],
"offsets": [
[
0,
99
]
]
}
] |
[
{
"id": "split_0_train_46738_entity",
"type": "progene_text",
"text": [
"cytokines"
],
"offsets": [
[
88,
97
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28819
|
split_0_train_28819
|
[
{
"id": "split_0_train_28819_passage",
"type": "progene_text",
"text": [
"It can be concluded that TNF , and to a lesser extent IL1 and IL6 , are positively related to the severity of osteolysis around the prosthesis and therefore a pharmacological treatment can be hypothesized with anti - inflammatory or anti - cytokine drugs in order to limit or to avoid prosthesis loosening ."
],
"offsets": [
[
0,
307
]
]
}
] |
[
{
"id": "split_0_train_46739_entity",
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"text": [
"TNF"
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25,
28
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{
"id": "split_0_train_46740_entity",
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54,
57
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{
"id": "split_0_train_46741_entity",
"type": "progene_text",
"text": [
"IL6"
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62,
65
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],
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{
"id": "split_0_train_46742_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
240,
248
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28820
|
split_0_train_28820
|
[
{
"id": "split_0_train_28820_passage",
"type": "progene_text",
"text": [
"New steps in the Wnt / beta-catenin signal transduction pathway ."
],
"offsets": [
[
0,
65
]
]
}
] |
[
{
"id": "split_0_train_46743_entity",
"type": "progene_text",
"text": [
"Wnt"
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"offsets": [
[
17,
20
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],
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},
{
"id": "split_0_train_46744_entity",
"type": "progene_text",
"text": [
"beta-catenin"
],
"offsets": [
[
23,
35
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28821
|
split_0_train_28821
|
[
{
"id": "split_0_train_28821_passage",
"type": "progene_text",
"text": [
"Wnt regulates developmental and oncogenic processes through its downstream effector , beta-catenin , and a set of other intracellular regulators that are largely conserved among species ."
],
"offsets": [
[
0,
187
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]
}
] |
[
{
"id": "split_0_train_46745_entity",
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"text": [
"Wnt"
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0,
3
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{
"id": "split_0_train_46746_entity",
"type": "progene_text",
"text": [
"beta-catenin"
],
"offsets": [
[
86,
98
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28822
|
split_0_train_28822
|
[
{
"id": "split_0_train_28822_passage",
"type": "progene_text",
"text": [
"Wnt family genes encode secreted glycoproteins that act as ligands for membrane receptors belonging to the Frizzled family of proteins ."
],
"offsets": [
[
0,
136
]
]
}
] |
[
{
"id": "split_0_train_46747_entity",
"type": "progene_text",
"text": [
"Wnt family"
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[
0,
10
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],
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},
{
"id": "split_0_train_46748_entity",
"type": "progene_text",
"text": [
"Frizzled family"
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"offsets": [
[
107,
122
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28823
|
split_0_train_28823
|
[
{
"id": "split_0_train_28823_passage",
"type": "progene_text",
"text": [
"Wnt-1 originally was found as a proto - oncogene that was upregulated in tumors caused by the mouse mammary tumor virus ."
],
"offsets": [
[
0,
121
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]
}
] |
[
{
"id": "split_0_train_46749_entity",
"type": "progene_text",
"text": [
"Wnt-1"
],
"offsets": [
[
0,
5
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28824
|
split_0_train_28824
|
[
{
"id": "split_0_train_28824_passage",
"type": "progene_text",
"text": [
"The Drosophila homologue of Wnt-1 , wingless , is a segment polarity gene that regulates body patterning of the fly embryo ."
],
"offsets": [
[
0,
124
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]
}
] |
[
{
"id": "split_0_train_46750_entity",
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28,
33
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{
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"text": [
"wingless"
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36,
44
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],
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}
] |
[] |
[] |
[] |
split_0_train_28825
|
split_0_train_28825
|
[
{
"id": "split_0_train_28825_passage",
"type": "progene_text",
"text": [
"In Xenopus , the Wnt pathway regulates formation of the ventral - dorsal axis ."
],
"offsets": [
[
0,
79
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]
}
] |
[
{
"id": "split_0_train_46752_entity",
"type": "progene_text",
"text": [
"Wnt"
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"offsets": [
[
17,
20
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28826
|
split_0_train_28826
|
[
{
"id": "split_0_train_28826_passage",
"type": "progene_text",
"text": [
"Although Wnt proteins are expressed widely in mammals , the function of the Wnt signaling pathway in normal adult mammalian tissues is not understood ."
],
"offsets": [
[
0,
151
]
]
}
] |
[
{
"id": "split_0_train_46753_entity",
"type": "progene_text",
"text": [
"Wnt"
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"offsets": [
[
9,
12
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],
"normalized": []
},
{
"id": "split_0_train_46754_entity",
"type": "progene_text",
"text": [
"Wnt"
],
"offsets": [
[
76,
79
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28827
|
split_0_train_28827
|
[
{
"id": "split_0_train_28827_passage",
"type": "progene_text",
"text": [
"Downstream components of the Wnt pathway , APC ( adenomatous polyposis coli ) and beta-catenin , clearly are involved in human cancer ."
],
"offsets": [
[
0,
135
]
]
}
] |
[
{
"id": "split_0_train_46755_entity",
"type": "progene_text",
"text": [
"Wnt"
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29,
32
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},
{
"id": "split_0_train_46756_entity",
"type": "progene_text",
"text": [
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43,
46
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],
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49,
75
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[] |
[] |
[] |
split_0_train_28828
|
split_0_train_28828
|
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[] |
[] |
[] |
split_0_train_28829
|
split_0_train_28829
|
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112,
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] |
[] |
[] |
[] |
split_0_train_28830
|
split_0_train_28830
|
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] |
[] |
[] |
[] |
split_0_train_28831
|
split_0_train_28831
|
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"text": [
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36,
41
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}
] |
[] |
[] |
[] |
split_0_train_28832
|
split_0_train_28832
|
[
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"Recent studies have shown that some of the intracellular signaling molecules that mediate the Wnt pathway are in complexes , including Dishevelled ( Dsh or Dvl ) , GSK-3beta , and APC protein ."
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0,
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"text": [
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180,
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}
] |
[] |
[] |
[] |
split_0_train_28833
|
split_0_train_28833
|
[
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"type": "progene_text",
"text": [
"However , little is known about how Wnt or other upstream stimuli regulate these complexes to stabilize beta-catenin ."
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}
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"text": [
"beta-catenin"
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104,
116
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}
] |
[] |
[] |
[] |
split_0_train_28834
|
split_0_train_28834
|
[
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"type": "progene_text",
"text": [
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"text": [
"Wnt"
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66,
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}
] |
[] |
[] |
[] |
split_0_train_28835
|
split_0_train_28835
|
[
{
"id": "split_0_train_28835_passage",
"type": "progene_text",
"text": [
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}
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133,
136
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}
] |
[] |
[] |
[] |
split_0_train_28836
|
split_0_train_28836
|
[
{
"id": "split_0_train_28836_passage",
"type": "progene_text",
"text": [
"Overexpression of CKIepsilon mimics Wnt by stabilizing beta-catenin , thereby increasing expression of beta-catenin - dependent genes ."
],
"offsets": [
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0,
135
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]
}
] |
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"text": [
"beta-catenin"
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"offsets": [
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103,
115
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}
] |
[] |
[] |
[] |
split_0_train_28837
|
split_0_train_28837
|
[
{
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"type": "progene_text",
"text": [
"Inhibition of endogenous CKIepsilon attenuated gene transcription stimulated by Wnt or by Dsh ."
],
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0,
95
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}
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"text": [
"Dsh"
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"offsets": [
[
90,
93
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28838
|
split_0_train_28838
|
[
{
"id": "split_0_train_28838_passage",
"type": "progene_text",
"text": [
"CKIepsilon forms a complex with Axin and the other downstream components of the Wnt pathway ."
],
"offsets": [
[
0,
93
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]
}
] |
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{
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"type": "progene_text",
"text": [
"Wnt"
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"offsets": [
[
80,
83
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28839
|
split_0_train_28839
|
[
{
"id": "split_0_train_28839_passage",
"type": "progene_text",
"text": [
"CKIepsilon is a positive regulator of the Wnt pathway and a possible functional link between upstream signals and the intracellular Axin signaling complex that regulates beta-catenin ."
],
"offsets": [
[
0,
184
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]
}
] |
[
{
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"text": [
"beta-catenin"
],
"offsets": [
[
170,
182
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28840
|
split_0_train_28840
|
[
{
"id": "split_0_train_28840_passage",
"type": "progene_text",
"text": [
"In separate experiments , we have identified a Dishevelled - associated kinase ( DAK ) that binds to Dsh and regulates its functions ."
],
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[
0,
134
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]
}
] |
[
{
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47,
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"type": "progene_text",
"text": [
"Dsh"
],
"offsets": [
[
101,
104
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28841
|
split_0_train_28841
|
[
{
"id": "split_0_train_28841_passage",
"type": "progene_text",
"text": [
"Dsh is required for two different pathways , the Wnt pathway and planar polarity pathway in Drosophila ."
],
"offsets": [
[
0,
104
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]
}
] |
[
{
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"type": "progene_text",
"text": [
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0,
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"type": "progene_text",
"text": [
"Wnt"
],
"offsets": [
[
49,
52
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28842
|
split_0_train_28842
|
[
{
"id": "split_0_train_28842_passage",
"type": "progene_text",
"text": [
"DAK dramatically enhances the function of Dsh in the Wnt pathway and inhibits its function in the planar polarity pathway ."
],
"offsets": [
[
0,
123
]
]
}
] |
[
{
"id": "split_0_train_46803_entity",
"type": "progene_text",
"text": [
"Dsh"
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42,
45
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{
"id": "split_0_train_46804_entity",
"type": "progene_text",
"text": [
"Wnt"
],
"offsets": [
[
53,
56
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28843
|
split_0_train_28843
|
[
{
"id": "split_0_train_28843_passage",
"type": "progene_text",
"text": [
"This chapter will discuss these newly identified components of the Wnt pathway ."
],
"offsets": [
[
0,
80
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]
}
] |
[
{
"id": "split_0_train_46805_entity",
"type": "progene_text",
"text": [
"Wnt"
],
"offsets": [
[
67,
70
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28844
|
split_0_train_28844
|
[
{
"id": "split_0_train_28844_passage",
"type": "progene_text",
"text": [
"In vivo expression of the interleukin 4 receptor alpha by astrocytes in epilepsy cerebral cortex ."
],
"offsets": [
[
0,
98
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]
}
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[
{
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"text": [
"interleukin 4 receptor alpha"
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"offsets": [
[
26,
54
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}
] |
[] |
[] |
[] |
split_0_train_28845
|
split_0_train_28845
|
[
{
"id": "split_0_train_28845_passage",
"type": "progene_text",
"text": [
"We reported previously that non - neoplastic astrocytes ( derived from brain tissues of patients with epilepsy ) expressed interleukin 4 receptor alpha ( IL-4Ralpha ) and responded to interleukin 4 ( IL-4 ) in culture ."
],
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[
0,
219
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}
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[
{
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123,
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{
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154,
164
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{
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184,
197
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"type": "progene_text",
"text": [
"IL-4"
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"offsets": [
[
200,
204
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28846
|
split_0_train_28846
|
[
{
"id": "split_0_train_28846_passage",
"type": "progene_text",
"text": [
"To determine whether reactivity of cultured astrocytes was relevant to primary tissue , we investigated IL-4Ralpha expression in specimens of non - neoplastic cerebral cortex removed for surgical treatment of intractable epilepsy compared to specimens of glial tumours , which have been reported to contain IL-4Ralpha ."
],
"offsets": [
[
0,
319
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]
}
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[
{
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104,
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"text": [
"IL-4Ralpha"
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"offsets": [
[
307,
317
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}
] |
[] |
[] |
[] |
split_0_train_28847
|
split_0_train_28847
|
[
{
"id": "split_0_train_28847_passage",
"type": "progene_text",
"text": [
"Freshly frozen tissues from eight cases ( four epilepsy , four malignant astrocytoma ) were evaluated for IL-4Ralpha expression by reverse - transcriptase polymerase chain reaction ( RT - PCR ) , Southern blotting , and double - labelled immunohistochemistry with antibodies to IL-4Ralpha and glial fibrillary acidic protein ( GFAP ) ."
],
"offsets": [
[
0,
335
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]
}
] |
[
{
"id": "split_0_train_46813_entity",
"type": "progene_text",
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106,
116
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"type": "progene_text",
"text": [
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278,
288
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{
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"type": "progene_text",
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293,
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{
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"type": "progene_text",
"text": [
"GFAP"
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"offsets": [
[
327,
331
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28848
|
split_0_train_28848
|
[
{
"id": "split_0_train_28848_passage",
"type": "progene_text",
"text": [
"IL-4Ralpha mRNA was detectable in both non - neoplastic and neoplastic tissues , whereas interleukin 2 receptor gamma chain ( IL-2Rgammac ) mRNA was not found ."
],
"offsets": [
[
0,
160
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]
}
] |
[
{
"id": "split_0_train_46817_entity",
"type": "progene_text",
"text": [
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0,
10
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{
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89,
117
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{
"id": "split_0_train_46819_entity",
"type": "progene_text",
"text": [
"IL-2Rgammac"
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"offsets": [
[
126,
137
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28849
|
split_0_train_28849
|
[
{
"id": "split_0_train_28849_passage",
"type": "progene_text",
"text": [
"By immunohistochemistry , IL-4Ralpha protein co - localized to cells displaying GFAP and astrocytic morphology in epilepsy tissues ."
],
"offsets": [
[
0,
132
]
]
}
] |
[
{
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26,
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{
"id": "split_0_train_46821_entity",
"type": "progene_text",
"text": [
"GFAP"
],
"offsets": [
[
80,
84
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28850
|
split_0_train_28850
|
[
{
"id": "split_0_train_28850_passage",
"type": "progene_text",
"text": [
"As anticipated , IL-4Ralpha was detectable in astrocytoma , but , surprisingly , was also observed in GFAP - positive , non - neoplastic \" reactive \" astrocytes adjacent to tumour ."
],
"offsets": [
[
0,
181
]
]
}
] |
[
{
"id": "split_0_train_46822_entity",
"type": "progene_text",
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"IL-4Ralpha"
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17,
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{
"id": "split_0_train_46823_entity",
"type": "progene_text",
"text": [
"GFAP"
],
"offsets": [
[
102,
106
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28851
|
split_0_train_28851
|
[
{
"id": "split_0_train_28851_passage",
"type": "progene_text",
"text": [
"Results are consistent with the concept that non - neoplastic epilepsy astrocytes express IL-4Ralpha in situ , thus confirming in vitro studies and implying IL-4 sensitivity in vivo ."
],
"offsets": [
[
0,
183
]
]
}
] |
[
{
"id": "split_0_train_46824_entity",
"type": "progene_text",
"text": [
"IL-4Ralpha"
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90,
100
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{
"id": "split_0_train_46825_entity",
"type": "progene_text",
"text": [
"IL-4"
],
"offsets": [
[
157,
161
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28852
|
split_0_train_28852
|
[
{
"id": "split_0_train_28852_passage",
"type": "progene_text",
"text": [
"Multiple histidine kinases regulate entry into stationary phase and sporulation in Bacillus subtilis ."
],
"offsets": [
[
0,
102
]
]
}
] |
[
{
"id": "split_0_train_46826_entity",
"type": "progene_text",
"text": [
"histidine kinases"
],
"offsets": [
[
9,
26
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28853
|
split_0_train_28853
|
[
{
"id": "split_0_train_28853_passage",
"type": "progene_text",
"text": [
"Protein homology studies identified five kinases potentially capable of phosphorylating the Spo0F response regulator and initiating sporulation in Bacillus subtilis ."
],
"offsets": [
[
0,
166
]
]
}
] |
[
{
"id": "split_0_train_46827_entity",
"type": "progene_text",
"text": [
"kinases"
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41,
48
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{
"id": "split_0_train_46828_entity",
"type": "progene_text",
"text": [
"Spo0F"
],
"offsets": [
[
92,
97
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28854
|
split_0_train_28854
|
[
{
"id": "split_0_train_28854_passage",
"type": "progene_text",
"text": [
"Two of these kinases , KinA and KinB , were known from previous studies to be responsible for sporulation in laboratory media ."
],
"offsets": [
[
0,
127
]
]
}
] |
[
{
"id": "split_0_train_46829_entity",
"type": "progene_text",
"text": [
"kinases"
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[
13,
20
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"normalized": []
},
{
"id": "split_0_train_46830_entity",
"type": "progene_text",
"text": [
"KinA"
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"offsets": [
[
23,
27
]
],
"normalized": []
},
{
"id": "split_0_train_46831_entity",
"type": "progene_text",
"text": [
"KinB"
],
"offsets": [
[
32,
36
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28855
|
split_0_train_28855
|
[
{
"id": "split_0_train_28855_passage",
"type": "progene_text",
"text": [
"In vivo studies of the activity of four of the kinases , KinA , KinC , KinD ( ykvD ) and KinE ( ykrQ ) , using abrB transcription as an indicator of Spo0A approximately P level , revealed that KinC and KinD were responsible for Spo0A approximately P production during the exponential phase of growth in the absence of KinA and KinB ."
],
"offsets": [
[
0,
333
]
]
}
] |
[
{
"id": "split_0_train_46832_entity",
"type": "progene_text",
"text": [
"kinases"
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[
47,
54
]
],
"normalized": []
},
{
"id": "split_0_train_46833_entity",
"type": "progene_text",
"text": [
"KinA"
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[
57,
61
]
],
"normalized": []
},
{
"id": "split_0_train_46834_entity",
"type": "progene_text",
"text": [
"KinC"
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[
64,
68
]
],
"normalized": []
},
{
"id": "split_0_train_46835_entity",
"type": "progene_text",
"text": [
"KinD"
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[
71,
75
]
],
"normalized": []
},
{
"id": "split_0_train_46836_entity",
"type": "progene_text",
"text": [
"ykvD"
],
"offsets": [
[
78,
82
]
],
"normalized": []
},
{
"id": "split_0_train_46837_entity",
"type": "progene_text",
"text": [
"KinE"
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89,
93
]
],
"normalized": []
},
{
"id": "split_0_train_46838_entity",
"type": "progene_text",
"text": [
"ykrQ"
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[
96,
100
]
],
"normalized": []
},
{
"id": "split_0_train_46839_entity",
"type": "progene_text",
"text": [
"abrB"
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[
111,
115
]
],
"normalized": []
},
{
"id": "split_0_train_46840_entity",
"type": "progene_text",
"text": [
"Spo0A"
],
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[
149,
154
]
],
"normalized": []
},
{
"id": "split_0_train_46841_entity",
"type": "progene_text",
"text": [
"KinC"
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"offsets": [
[
193,
197
]
],
"normalized": []
},
{
"id": "split_0_train_46842_entity",
"type": "progene_text",
"text": [
"KinD"
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[
202,
206
]
],
"normalized": []
},
{
"id": "split_0_train_46843_entity",
"type": "progene_text",
"text": [
"Spo0A"
],
"offsets": [
[
228,
233
]
],
"normalized": []
},
{
"id": "split_0_train_46844_entity",
"type": "progene_text",
"text": [
"KinA"
],
"offsets": [
[
318,
322
]
],
"normalized": []
},
{
"id": "split_0_train_46845_entity",
"type": "progene_text",
"text": [
"KinB"
],
"offsets": [
[
327,
331
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28856
|
split_0_train_28856
|
[
{
"id": "split_0_train_28856_passage",
"type": "progene_text",
"text": [
"In vitro , all four kinases dephosphorylated Spo0F approximately P with the production of ATP at approximately the same rate , indicating that they possess approximately equal affinity for Spo0F ."
],
"offsets": [
[
0,
196
]
]
}
] |
[
{
"id": "split_0_train_46846_entity",
"type": "progene_text",
"text": [
"kinases"
],
"offsets": [
[
20,
27
]
],
"normalized": []
},
{
"id": "split_0_train_46847_entity",
"type": "progene_text",
"text": [
"Spo0F"
],
"offsets": [
[
45,
50
]
],
"normalized": []
},
{
"id": "split_0_train_46848_entity",
"type": "progene_text",
"text": [
"Spo0F"
],
"offsets": [
[
189,
194
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28857
|
split_0_train_28857
|
[
{
"id": "split_0_train_28857_passage",
"type": "progene_text",
"text": [
"All the kinases were expressed during growth and early stationary phase , suggesting that the differential activity observed in growth and sporulation results from differential activation by signal ligands unique to each kinase ."
],
"offsets": [
[
0,
229
]
]
}
] |
[
{
"id": "split_0_train_46849_entity",
"type": "progene_text",
"text": [
"kinases"
],
"offsets": [
[
8,
15
]
],
"normalized": []
},
{
"id": "split_0_train_46850_entity",
"type": "progene_text",
"text": [
"kinase"
],
"offsets": [
[
221,
227
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28858
|
split_0_train_28858
|
[
{
"id": "split_0_train_28858_passage",
"type": "progene_text",
"text": [
"Identification of a novel acidic mammalian chitinase distinct from chitotriosidase ."
],
"offsets": [
[
0,
84
]
]
}
] |
[
{
"id": "split_0_train_46851_entity",
"type": "progene_text",
"text": [
"acidic mammalian chitinase"
],
"offsets": [
[
26,
52
]
],
"normalized": []
},
{
"id": "split_0_train_46852_entity",
"type": "progene_text",
"text": [
"chitotriosidase"
],
"offsets": [
[
67,
82
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28859
|
split_0_train_28859
|
[
{
"id": "split_0_train_28859_passage",
"type": "progene_text",
"text": [
"Chitinases are ubiquitous chitin - fragmenting hydrolases ."
],
"offsets": [
[
0,
59
]
]
}
] |
[
{
"id": "split_0_train_46853_entity",
"type": "progene_text",
"text": [
"Chitinases"
],
"offsets": [
[
0,
10
]
],
"normalized": []
},
{
"id": "split_0_train_46854_entity",
"type": "progene_text",
"text": [
"hydrolases"
],
"offsets": [
[
47,
57
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28860
|
split_0_train_28860
|
[
{
"id": "split_0_train_28860_passage",
"type": "progene_text",
"text": [
"Recently we discovered the first human chitinase , named chitotriosidase , that is specifically expressed by phagocytes ."
],
"offsets": [
[
0,
121
]
]
}
] |
[
{
"id": "split_0_train_46855_entity",
"type": "progene_text",
"text": [
"chitinase"
],
"offsets": [
[
39,
48
]
],
"normalized": []
},
{
"id": "split_0_train_46856_entity",
"type": "progene_text",
"text": [
"chitotriosidase"
],
"offsets": [
[
57,
72
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28861
|
split_0_train_28861
|
[
{
"id": "split_0_train_28861_passage",
"type": "progene_text",
"text": [
"We here report the identification , purification , and subsequent cloning of a second mammalian chitinase ."
],
"offsets": [
[
0,
107
]
]
}
] |
[
{
"id": "split_0_train_46857_entity",
"type": "progene_text",
"text": [
"chitinase"
],
"offsets": [
[
96,
105
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28862
|
split_0_train_28862
|
[
{
"id": "split_0_train_28862_passage",
"type": "progene_text",
"text": [
"This enzyme is characterized by an acidic isoelectric point and therefore named acidic mammalian chitinase ( AMCase ) ."
],
"offsets": [
[
0,
119
]
]
}
] |
[
{
"id": "split_0_train_46858_entity",
"type": "progene_text",
"text": [
"acidic mammalian chitinase"
],
"offsets": [
[
80,
106
]
],
"normalized": []
},
{
"id": "split_0_train_46859_entity",
"type": "progene_text",
"text": [
"AMCase"
],
"offsets": [
[
109,
115
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28863
|
split_0_train_28863
|
[
{
"id": "split_0_train_28863_passage",
"type": "progene_text",
"text": [
"In rodents and man the enzyme is relatively abundant in the gastrointestinal tract and is found to a lesser extent in the lung ."
],
"offsets": [
[
0,
128
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28864
|
split_0_train_28864
|
[
{
"id": "split_0_train_28864_passage",
"type": "progene_text",
"text": [
"Like chitotriosidase , AMCase is synthesized as a 50 - kDa protein containing a 39 - kDa N - terminal catalytic domain , a hinge region , and a C - terminal chitin - binding domain ."
],
"offsets": [
[
0,
182
]
]
}
] |
[
{
"id": "split_0_train_46860_entity",
"type": "progene_text",
"text": [
"chitotriosidase"
],
"offsets": [
[
5,
20
]
],
"normalized": []
},
{
"id": "split_0_train_46861_entity",
"type": "progene_text",
"text": [
"AMCase"
],
"offsets": [
[
23,
29
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28865
|
split_0_train_28865
|
[
{
"id": "split_0_train_28865_passage",
"type": "progene_text",
"text": [
"In contrast to chitotriosidase , the enzyme is extremely acid stable and shows a distinct second pH optimum around pH 2 ."
],
"offsets": [
[
0,
121
]
]
}
] |
[
{
"id": "split_0_train_46862_entity",
"type": "progene_text",
"text": [
"chitotriosidase"
],
"offsets": [
[
15,
30
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28866
|
split_0_train_28866
|
[
{
"id": "split_0_train_28866_passage",
"type": "progene_text",
"text": [
"AMCase is capable of cleaving artificial chitin - like substrates as well as crab shell chitin and chitin as present in the fungal cell wall ."
],
"offsets": [
[
0,
142
]
]
}
] |
[
{
"id": "split_0_train_46863_entity",
"type": "progene_text",
"text": [
"AMCase"
],
"offsets": [
[
0,
6
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28867
|
split_0_train_28867
|
[
{
"id": "split_0_train_28867_passage",
"type": "progene_text",
"text": [
"Our study has revealed the existence of a chitinolytic enzyme in the gastrointestinal tract and lung that may play a role in digestion and/or defense ."
],
"offsets": [
[
0,
151
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28868
|
split_0_train_28868
|
[
{
"id": "split_0_train_28868_passage",
"type": "progene_text",
"text": [
"Development - related increase in cortisol biosynthesis by human granulosa cells ."
],
"offsets": [
[
0,
82
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28869
|
split_0_train_28869
|
[
{
"id": "split_0_train_28869_passage",
"type": "progene_text",
"text": [
"Antiinflammatory mechanisms are important in ovulation and may be regulated by cortisol ( F ) ."
],
"offsets": [
[
0,
95
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28870
|
split_0_train_28870
|
[
{
"id": "split_0_train_28870_passage",
"type": "progene_text",
"text": [
"We previously showed that after administration of human ( h ) CG for ovulation induction , luteinized granulosa cells ( LGC ) abundantly express 11beta-hydroxysteroid dehydrogenase type 1 ( 11betaHSD1 ) messenger RNA but not 11betaHSD type 2 ( 11betaHSD2 ) messenger RNA ."
],
"offsets": [
[
0,
272
]
]
}
] |
[
{
"id": "split_0_train_46864_entity",
"type": "progene_text",
"text": [
"CG"
],
"offsets": [
[
62,
64
]
],
"normalized": []
},
{
"id": "split_0_train_46865_entity",
"type": "progene_text",
"text": [
"11beta-hydroxysteroid dehydrogenase type 1"
],
"offsets": [
[
145,
187
]
],
"normalized": []
},
{
"id": "split_0_train_46866_entity",
"type": "progene_text",
"text": [
"11betaHSD1"
],
"offsets": [
[
190,
200
]
],
"normalized": []
},
{
"id": "split_0_train_46867_entity",
"type": "progene_text",
"text": [
"11betaHSD type 2"
],
"offsets": [
[
225,
241
]
],
"normalized": []
},
{
"id": "split_0_train_46868_entity",
"type": "progene_text",
"text": [
"11betaHSD2"
],
"offsets": [
[
244,
254
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28871
|
split_0_train_28871
|
[
{
"id": "split_0_train_28871_passage",
"type": "progene_text",
"text": [
"11ssHSD1 is responsible for the reversible formation of antiinflammatory F from its inactive precursor cortisone ( E ) , whereas 11betaHSD2 unidirectionally converts F to E through 11-oxidation ."
],
"offsets": [
[
0,
195
]
]
}
] |
[
{
"id": "split_0_train_46869_entity",
"type": "progene_text",
"text": [
"11ssHSD1"
],
"offsets": [
[
0,
8
]
],
"normalized": []
},
{
"id": "split_0_train_46870_entity",
"type": "progene_text",
"text": [
"11betaHSD2"
],
"offsets": [
[
129,
139
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28872
|
split_0_train_28872
|
[
{
"id": "split_0_train_28872_passage",
"type": "progene_text",
"text": [
"This pattern of gene expression predicts that LGC from periovulatory follicles would show increased activation of E to F , compared with granulosa cells from immature follicles ( IGC ) , and that follicular fluid concentrations of E and F would alter accordingly ."
],
"offsets": [
[
0,
264
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28873
|
split_0_train_28873
|
[
{
"id": "split_0_train_28873_passage",
"type": "progene_text",
"text": [
"To test this hypothesis , we isolated IGC , thecal cells ( TC ) , and follicular fluid , from ovaries of cyclic women , removed during surgery for benign gynecological disease ."
],
"offsets": [
[
0,
177
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28874
|
split_0_train_28874
|
[
{
"id": "split_0_train_28874_passage",
"type": "progene_text",
"text": [
"LGC and follicular fluid were aspirated from periovulatory follicles , 35 h after hCG injection , in patients undergoing in vitro fertilization treatment ."
],
"offsets": [
[
0,
155
]
]
}
] |
[
{
"id": "split_0_train_46871_entity",
"type": "progene_text",
"text": [
"hCG"
],
"offsets": [
[
82,
85
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28875
|
split_0_train_28875
|
[
{
"id": "split_0_train_28875_passage",
"type": "progene_text",
"text": [
"In an 11betaHSD assay based on interconversion of tritiated E and F by cell suspensions in vitro , IGC ( % conversion , 0.6 +/- 0.4 , mean +/- SEM ) and collagenase - dispersed TC ( 0.2 +/- 0.1 % ) were unable to convert E to F , whereas LGC ( 36.3 +/- 3.7 % ) were highly efficient at this reaction ."
],
"offsets": [
[
0,
301
]
]
}
] |
[
{
"id": "split_0_train_46872_entity",
"type": "progene_text",
"text": [
"11betaHSD"
],
"offsets": [
[
6,
15
]
],
"normalized": []
},
{
"id": "split_0_train_46873_entity",
"type": "progene_text",
"text": [
"collagenase"
],
"offsets": [
[
153,
164
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28876
|
split_0_train_28876
|
[
{
"id": "split_0_train_28876_passage",
"type": "progene_text",
"text": [
"Immature granulosa cells , LGC , and ( to a lesser extent ) TC were all able to convert F to E ."
],
"offsets": [
[
0,
96
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28877
|
split_0_train_28877
|
[
{
"id": "split_0_train_28877_passage",
"type": "progene_text",
"text": [
"Correspondingly , follicular fluid concentrations of total F and F : E ratios were significantly higher in periovulatory follicles , compared with immature follicles ."
],
"offsets": [
[
0,
167
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28878
|
split_0_train_28878
|
[
{
"id": "split_0_train_28878_passage",
"type": "progene_text",
"text": [
"Culturing IGC for 48 h in the presence of hFSH resulted in increased 11betaHSD1 reductase activity , paralleling stimulation of estrogen ( aromatase activity ) and progesterone biosynthesis ."
],
"offsets": [
[
0,
191
]
]
}
] |
[
{
"id": "split_0_train_46874_entity",
"type": "progene_text",
"text": [
"hFSH"
],
"offsets": [
[
42,
46
]
],
"normalized": []
},
{
"id": "split_0_train_46875_entity",
"type": "progene_text",
"text": [
"11betaHSD1 reductase"
],
"offsets": [
[
69,
89
]
],
"normalized": []
},
{
"id": "split_0_train_46876_entity",
"type": "progene_text",
"text": [
"aromatase"
],
"offsets": [
[
139,
148
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28879
|
split_0_train_28879
|
[
{
"id": "split_0_train_28879_passage",
"type": "progene_text",
"text": [
"Similar treatment with hLH did not influence 11betaHSD1 reductase activity , except in a patient with more mature IGC , which also showed a significant increase in E-to-F conversion , as well as progesterone synthesis in response to hLH ."
],
"offsets": [
[
0,
238
]
]
}
] |
[
{
"id": "split_0_train_46877_entity",
"type": "progene_text",
"text": [
"hLH"
],
"offsets": [
[
23,
26
]
],
"normalized": []
},
{
"id": "split_0_train_46878_entity",
"type": "progene_text",
"text": [
"11betaHSD1 reductase"
],
"offsets": [
[
45,
65
]
],
"normalized": []
},
{
"id": "split_0_train_46879_entity",
"type": "progene_text",
"text": [
"hLH"
],
"offsets": [
[
233,
236
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28880
|
split_0_train_28880
|
[
{
"id": "split_0_train_28880_passage",
"type": "progene_text",
"text": [
"These data confirm that 11betaHSD activity in the human ovary is developmentally regulated and gonadotropin responsive , favoring metabolism of F to E in immature follicles and E to F in periovulatory follicles ."
],
"offsets": [
[
0,
212
]
]
}
] |
[
{
"id": "split_0_train_46880_entity",
"type": "progene_text",
"text": [
"11betaHSD"
],
"offsets": [
[
24,
33
]
],
"normalized": []
},
{
"id": "split_0_train_46881_entity",
"type": "progene_text",
"text": [
"gonadotropin"
],
"offsets": [
[
95,
107
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28881
|
split_0_train_28881
|
[
{
"id": "split_0_train_28881_passage",
"type": "progene_text",
"text": [
"Increased formation of F by LGC in periovulatory follicles is consistent with an antiinflammatory function for this glucocorticoid at ovulation ."
],
"offsets": [
[
0,
145
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28882
|
split_0_train_28882
|
[
{
"id": "split_0_train_28882_passage",
"type": "progene_text",
"text": [
"The skeletal muscle ryanodine receptor identified as a molecular target of [3H]azidodantrolene by photoaffinity labeling ."
],
"offsets": [
[
0,
122
]
]
}
] |
[
{
"id": "split_0_train_46882_entity",
"type": "progene_text",
"text": [
"skeletal muscle ryanodine receptor"
],
"offsets": [
[
4,
38
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28883
|
split_0_train_28883
|
[
{
"id": "split_0_train_28883_passage",
"type": "progene_text",
"text": [
"Dantrolene is a skeletal muscle relaxant which acts by inhibiting intracellular Ca(2+) release from sarcoplasmic reticulum ( SR ) ."
],
"offsets": [
[
0,
131
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28884
|
split_0_train_28884
|
[
{
"id": "split_0_train_28884_passage",
"type": "progene_text",
"text": [
"It is used primarily in the treatment of malignant hyperthermia ( MH ) , a pharmacogenetic sensitivity to volatile anesthetics resulting in massive intracellular Ca(2+) release ."
],
"offsets": [
[
0,
178
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28885
|
split_0_train_28885
|
[
{
"id": "split_0_train_28885_passage",
"type": "progene_text",
"text": [
"Determination of the site and mechanism of action of dantrolene should contribute to the understanding of the regulation of intracellular Ca(2+) release in skeletal muscle ."
],
"offsets": [
[
0,
173
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28886
|
split_0_train_28886
|
[
{
"id": "split_0_train_28886_passage",
"type": "progene_text",
"text": [
"Photoaffinity labeling of porcine SR with [(3)H]azidodantrolene , a photoactivatable analogue of dantrolene , has identified a 160 kDa SR protein with immunologic cross - reactivity to skeletal muscle ryanodine receptor ( RyR ) as a possible target [ Palnitkar et al. ( 1999 ) J. Med. Chem. 42 , 1872 - 1880 ] ."
],
"offsets": [
[
0,
311
]
]
}
] |
[
{
"id": "split_0_train_46883_entity",
"type": "progene_text",
"text": [
"skeletal muscle ryanodine receptor"
],
"offsets": [
[
185,
219
]
],
"normalized": []
},
{
"id": "split_0_train_46884_entity",
"type": "progene_text",
"text": [
"RyR"
],
"offsets": [
[
222,
225
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28887
|
split_0_train_28887
|
[
{
"id": "split_0_train_28887_passage",
"type": "progene_text",
"text": [
"Here we demonstrate specific , AMP-PCP - enhanced , [(3)H]azidodantrolene photolabeling of both the RyR monomer and a 160 or 172 kDa protein in porcine and rabbit SR , respectively ."
],
"offsets": [
[
0,
182
]
]
}
] |
[
{
"id": "split_0_train_46885_entity",
"type": "progene_text",
"text": [
"RyR"
],
"offsets": [
[
100,
103
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28888
|
split_0_train_28888
|
[
{
"id": "split_0_train_28888_passage",
"type": "progene_text",
"text": [
"The 160 / 172 kDa protein is shown to be the NH(2) - terminus of the RyR cleaved from the monomer by an endogenous protease activity consistent with that of n-calpain ."
],
"offsets": [
[
0,
168
]
]
}
] |
[
{
"id": "split_0_train_46886_entity",
"type": "progene_text",
"text": [
"RyR"
],
"offsets": [
[
69,
72
]
],
"normalized": []
},
{
"id": "split_0_train_46887_entity",
"type": "progene_text",
"text": [
"protease"
],
"offsets": [
[
115,
123
]
],
"normalized": []
},
{
"id": "split_0_train_46888_entity",
"type": "progene_text",
"text": [
"n-calpain"
],
"offsets": [
[
157,
166
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28889
|
split_0_train_28889
|
[
{
"id": "split_0_train_28889_passage",
"type": "progene_text",
"text": [
"MALDI - mass spectrometric analysis of the porcine 160 kDa protein identifies it as the 1400 amino acid NH(2) - terminal fragment of the skeletal muscle RyR reportedly generated by n-calpain [ Shevchenko et al. ( 1998 ) J. Membr. Biol. 161 , 33 - 34 ] ."
],
"offsets": [
[
0,
253
]
]
}
] |
[
{
"id": "split_0_train_46889_entity",
"type": "progene_text",
"text": [
"skeletal muscle RyR"
],
"offsets": [
[
137,
156
]
],
"normalized": []
},
{
"id": "split_0_train_46890_entity",
"type": "progene_text",
"text": [
"n-calpain"
],
"offsets": [
[
181,
190
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28890
|
split_0_train_28890
|
[
{
"id": "split_0_train_28890_passage",
"type": "progene_text",
"text": [
"Immunoprecipitation of solubilized , [(3)H]azidodantrolene-photolabeled SR protein reveals that the cleaved 160 / 172 kDa protein remains associated with the C - terminal , 410 kDa portion of the RyR ."
],
"offsets": [
[
0,
201
]
]
}
] |
[
{
"id": "split_0_train_46891_entity",
"type": "progene_text",
"text": [
"RyR"
],
"offsets": [
[
196,
199
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28891
|
split_0_train_28891
|
[
{
"id": "split_0_train_28891_passage",
"type": "progene_text",
"text": [
"[(3)H]Dantrolene binding to both the intact and the n - calpain - cleaved channel RyR is similarly enhanced by AMP-PCP ."
],
"offsets": [
[
0,
120
]
]
}
] |
[
{
"id": "split_0_train_46892_entity",
"type": "progene_text",
"text": [
"n - calpain"
],
"offsets": [
[
52,
63
]
],
"normalized": []
},
{
"id": "split_0_train_46893_entity",
"type": "progene_text",
"text": [
"RyR"
],
"offsets": [
[
82,
85
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28892
|
split_0_train_28892
|
[
{
"id": "split_0_train_28892_passage",
"type": "progene_text",
"text": [
"n-Calpain cleavage of the RyR does not affect [(3)H]dantrolene binding in the presence of AMP-PCP , but depresses drug binding in the absence of nucleotide ."
],
"offsets": [
[
0,
157
]
]
}
] |
[
{
"id": "split_0_train_46894_entity",
"type": "progene_text",
"text": [
"n-Calpain"
],
"offsets": [
[
0,
9
]
],
"normalized": []
},
{
"id": "split_0_train_46895_entity",
"type": "progene_text",
"text": [
"RyR"
],
"offsets": [
[
26,
29
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28893
|
split_0_train_28893
|
[
{
"id": "split_0_train_28893_passage",
"type": "progene_text",
"text": [
"These results demonstrate that the NH(2) - terminus of the RyR is a molecular target for dantrolene , and suggest a regulatory role for both n-calpain activity and ATP in the interaction of dantrolene with the RyR in vivo ."
],
"offsets": [
[
0,
223
]
]
}
] |
[
{
"id": "split_0_train_46896_entity",
"type": "progene_text",
"text": [
"RyR"
],
"offsets": [
[
59,
62
]
],
"normalized": []
},
{
"id": "split_0_train_46897_entity",
"type": "progene_text",
"text": [
"n-calpain"
],
"offsets": [
[
141,
150
]
],
"normalized": []
},
{
"id": "split_0_train_46898_entity",
"type": "progene_text",
"text": [
"RyR"
],
"offsets": [
[
210,
213
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28894
|
split_0_train_28894
|
[
{
"id": "split_0_train_28894_passage",
"type": "progene_text",
"text": [
"The polycomb group protein EED interacts with YY1 , and both proteins induce neural tissue in Xenopus embryos ."
],
"offsets": [
[
0,
111
]
]
}
] |
[
{
"id": "split_0_train_46899_entity",
"type": "progene_text",
"text": [
"polycomb group protein"
],
"offsets": [
[
4,
26
]
],
"normalized": []
},
{
"id": "split_0_train_46900_entity",
"type": "progene_text",
"text": [
"EED"
],
"offsets": [
[
27,
30
]
],
"normalized": []
},
{
"id": "split_0_train_46901_entity",
"type": "progene_text",
"text": [
"YY1"
],
"offsets": [
[
46,
49
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28895
|
split_0_train_28895
|
[
{
"id": "split_0_train_28895_passage",
"type": "progene_text",
"text": [
"Polycomb group ( PcG ) proteins form multimeric protein complexes which are involved in the heritable stable repression of genes ."
],
"offsets": [
[
0,
130
]
]
}
] |
[
{
"id": "split_0_train_46902_entity",
"type": "progene_text",
"text": [
"Polycomb group ( PcG ) proteins"
],
"offsets": [
[
0,
31
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28896
|
split_0_train_28896
|
[
{
"id": "split_0_train_28896_passage",
"type": "progene_text",
"text": [
"Previously , we identified two distinct human PcG protein complexes ."
],
"offsets": [
[
0,
69
]
]
}
] |
[
{
"id": "split_0_train_46903_entity",
"type": "progene_text",
"text": [
"PcG protein"
],
"offsets": [
[
46,
57
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28897
|
split_0_train_28897
|
[
{
"id": "split_0_train_28897_passage",
"type": "progene_text",
"text": [
"The EED - EZH protein complex contains the EED and EZH2 PcG proteins , and the HPC-HPH PcG complex contains the HPC , HPH , BMI1 , and RING1 PcG proteins ."
],
"offsets": [
[
0,
155
]
]
}
] |
[
{
"id": "split_0_train_46904_entity",
"type": "progene_text",
"text": [
"EED"
],
"offsets": [
[
4,
7
]
],
"normalized": []
},
{
"id": "split_0_train_46905_entity",
"type": "progene_text",
"text": [
"EZH"
],
"offsets": [
[
10,
13
]
],
"normalized": []
},
{
"id": "split_0_train_46906_entity",
"type": "progene_text",
"text": [
"EED"
],
"offsets": [
[
43,
46
]
],
"normalized": []
},
{
"id": "split_0_train_46907_entity",
"type": "progene_text",
"text": [
"EZH2"
],
"offsets": [
[
51,
55
]
],
"normalized": []
},
{
"id": "split_0_train_46908_entity",
"type": "progene_text",
"text": [
"PcG proteins"
],
"offsets": [
[
56,
68
]
],
"normalized": []
},
{
"id": "split_0_train_46909_entity",
"type": "progene_text",
"text": [
"HPC-HPH PcG complex"
],
"offsets": [
[
79,
98
]
],
"normalized": []
},
{
"id": "split_0_train_46910_entity",
"type": "progene_text",
"text": [
"HPC"
],
"offsets": [
[
112,
115
]
],
"normalized": []
},
{
"id": "split_0_train_46911_entity",
"type": "progene_text",
"text": [
"HPH"
],
"offsets": [
[
118,
121
]
],
"normalized": []
},
{
"id": "split_0_train_46912_entity",
"type": "progene_text",
"text": [
"BMI1"
],
"offsets": [
[
124,
128
]
],
"normalized": []
},
{
"id": "split_0_train_46913_entity",
"type": "progene_text",
"text": [
"RING1"
],
"offsets": [
[
135,
140
]
],
"normalized": []
},
{
"id": "split_0_train_46914_entity",
"type": "progene_text",
"text": [
"PcG proteins"
],
"offsets": [
[
141,
153
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28898
|
split_0_train_28898
|
[
{
"id": "split_0_train_28898_passage",
"type": "progene_text",
"text": [
"Here we show that YY1 , a homolog of the Drosophila PcG protein pleiohomeotic ( Pho ) , interacts specificially with the human PcG protein EED but not with proteins of the HPC-HPH PcG complex ."
],
"offsets": [
[
0,
193
]
]
}
] |
[
{
"id": "split_0_train_46915_entity",
"type": "progene_text",
"text": [
"YY1"
],
"offsets": [
[
18,
21
]
],
"normalized": []
},
{
"id": "split_0_train_46916_entity",
"type": "progene_text",
"text": [
"PcG protein"
],
"offsets": [
[
52,
63
]
],
"normalized": []
},
{
"id": "split_0_train_46917_entity",
"type": "progene_text",
"text": [
"pleiohomeotic"
],
"offsets": [
[
64,
77
]
],
"normalized": []
},
{
"id": "split_0_train_46918_entity",
"type": "progene_text",
"text": [
"Pho"
],
"offsets": [
[
80,
83
]
],
"normalized": []
},
{
"id": "split_0_train_46919_entity",
"type": "progene_text",
"text": [
"PcG protein"
],
"offsets": [
[
127,
138
]
],
"normalized": []
},
{
"id": "split_0_train_46920_entity",
"type": "progene_text",
"text": [
"EED"
],
"offsets": [
[
139,
142
]
],
"normalized": []
},
{
"id": "split_0_train_46921_entity",
"type": "progene_text",
"text": [
"HPC-HPH PcG complex"
],
"offsets": [
[
172,
191
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28899
|
split_0_train_28899
|
[
{
"id": "split_0_train_28899_passage",
"type": "progene_text",
"text": [
"Since YY1 and Pho are DNA - binding proteins , the interaction between YY1 and EED provides a direct link between the chromatin - associated EED - EZH PcG complex and the DNA of target genes ."
],
"offsets": [
[
0,
192
]
]
}
] |
[
{
"id": "split_0_train_46922_entity",
"type": "progene_text",
"text": [
"YY1"
],
"offsets": [
[
6,
9
]
],
"normalized": []
},
{
"id": "split_0_train_46923_entity",
"type": "progene_text",
"text": [
"Pho"
],
"offsets": [
[
14,
17
]
],
"normalized": []
},
{
"id": "split_0_train_46924_entity",
"type": "progene_text",
"text": [
"YY1"
],
"offsets": [
[
71,
74
]
],
"normalized": []
},
{
"id": "split_0_train_46925_entity",
"type": "progene_text",
"text": [
"EED"
],
"offsets": [
[
79,
82
]
],
"normalized": []
},
{
"id": "split_0_train_46926_entity",
"type": "progene_text",
"text": [
"EED"
],
"offsets": [
[
141,
144
]
],
"normalized": []
},
{
"id": "split_0_train_46927_entity",
"type": "progene_text",
"text": [
"EZH"
],
"offsets": [
[
147,
150
]
],
"normalized": []
},
{
"id": "split_0_train_46928_entity",
"type": "progene_text",
"text": [
"PcG"
],
"offsets": [
[
151,
154
]
],
"normalized": []
}
] |
[] |
[] |
[] |
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