id
stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
split_0_train_29000
|
split_0_train_29000
|
[
{
"id": "split_0_train_29000_passage",
"type": "progene_text",
"text": [
"We have identified a novel galactose 3-O-sulfotransferase , termed Gal3ST - 4 , by analysis of an expression sequence tag using the amino acid sequence of human cerebroside 3'-sulfotransferase ( Gal3ST-1 ) ."
],
"offsets": [
[
0,
207
]
]
}
] |
[
{
"id": "split_0_train_47134_entity",
"type": "progene_text",
"text": [
"galactose 3-O-sulfotransferase"
],
"offsets": [
[
27,
57
]
],
"normalized": []
},
{
"id": "split_0_train_47135_entity",
"type": "progene_text",
"text": [
"Gal3ST - 4"
],
"offsets": [
[
67,
77
]
],
"normalized": []
},
{
"id": "split_0_train_47136_entity",
"type": "progene_text",
"text": [
"cerebroside 3'-sulfotransferase"
],
"offsets": [
[
161,
192
]
],
"normalized": []
},
{
"id": "split_0_train_47137_entity",
"type": "progene_text",
"text": [
"Gal3ST-1"
],
"offsets": [
[
195,
203
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29001
|
split_0_train_29001
|
[
{
"id": "split_0_train_29001_passage",
"type": "progene_text",
"text": [
"The isolated cDNA contains a single open reading frame coding for a protein of 486 amino acids with a type II transmembrane topology ."
],
"offsets": [
[
0,
134
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29002
|
split_0_train_29002
|
[
{
"id": "split_0_train_29002_passage",
"type": "progene_text",
"text": [
"The amino acid sequence of Gal3ST-4 revealed 33 % , 39 % , and 30 % identity to human Gal3ST-1 , Gal beta 1 --> 3 / 4GlcNAc : -->3'-sulfotransferase ( Gal3ST-2 ) and Gal beta 1 --> 4GlcNAc : --> 3' - sulfotransferase ( Gal3ST - 3 ) , respectively ."
],
"offsets": [
[
0,
248
]
]
}
] |
[
{
"id": "split_0_train_47138_entity",
"type": "progene_text",
"text": [
"Gal3ST-4"
],
"offsets": [
[
27,
35
]
],
"normalized": []
},
{
"id": "split_0_train_47139_entity",
"type": "progene_text",
"text": [
"Gal3ST-1"
],
"offsets": [
[
86,
94
]
],
"normalized": []
},
{
"id": "split_0_train_47140_entity",
"type": "progene_text",
"text": [
"Gal beta 1 --> 3 / 4GlcNAc : -->3'-sulfotransferase"
],
"offsets": [
[
97,
148
]
],
"normalized": []
},
{
"id": "split_0_train_47141_entity",
"type": "progene_text",
"text": [
"Gal3ST-2"
],
"offsets": [
[
151,
159
]
],
"normalized": []
},
{
"id": "split_0_train_47142_entity",
"type": "progene_text",
"text": [
"Gal beta 1 --> 4GlcNAc : --> 3' - sulfotransferase"
],
"offsets": [
[
166,
216
]
],
"normalized": []
},
{
"id": "split_0_train_47143_entity",
"type": "progene_text",
"text": [
"Gal3ST - 3"
],
"offsets": [
[
219,
229
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29003
|
split_0_train_29003
|
[
{
"id": "split_0_train_29003_passage",
"type": "progene_text",
"text": [
"The Gal3ST-4 gene comprised at least four exons and was located on human chromosome 7q22 ."
],
"offsets": [
[
0,
90
]
]
}
] |
[
{
"id": "split_0_train_47144_entity",
"type": "progene_text",
"text": [
"Gal3ST-4"
],
"offsets": [
[
4,
12
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29004
|
split_0_train_29004
|
[
{
"id": "split_0_train_29004_passage",
"type": "progene_text",
"text": [
"Expression of Gal3ST-4 in COS-7 cells produced a sulfotransferase activity that catalyzes the transfer of [(35)S]sulfate to the C-3' position of Gal beta 1 --> 3GalNAc alpha 1-O-Bn ."
],
"offsets": [
[
0,
182
]
]
}
] |
[
{
"id": "split_0_train_47145_entity",
"type": "progene_text",
"text": [
"Gal3ST-4"
],
"offsets": [
[
14,
22
]
],
"normalized": []
},
{
"id": "split_0_train_47146_entity",
"type": "progene_text",
"text": [
"sulfotransferase"
],
"offsets": [
[
49,
65
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29005
|
split_0_train_29005
|
[
{
"id": "split_0_train_29005_passage",
"type": "progene_text",
"text": [
"Gal3ST-4 recognizes Gal beta 1 --> 3GalNAc and Gal beta 1 --> 3 ( GlcNAc beta 1 --> 6 ) GalNAc as good substrates , but not Gal beta 1 --> 3GalNAc ( OH ) or Gal beta 1 -->3/4GlcNAc ."
],
"offsets": [
[
0,
182
]
]
}
] |
[
{
"id": "split_0_train_47147_entity",
"type": "progene_text",
"text": [
"Gal3ST-4"
],
"offsets": [
[
0,
8
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29006
|
split_0_train_29006
|
[
{
"id": "split_0_train_29006_passage",
"type": "progene_text",
"text": [
"Asialofetuin is also a good substrate , and the sulfation was found exclusively in O - linked glycans that consist of the Gal beta 1 --> 3GalNAc moiety , suggesting that the enzyme is specific for O - linked glycans ."
],
"offsets": [
[
0,
217
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29007
|
split_0_train_29007
|
[
{
"id": "split_0_train_29007_passage",
"type": "progene_text",
"text": [
"Northern blot analysis revealed that 2.5 - kilobase mRNA for the enzyme is expressed extensively in various tissues ."
],
"offsets": [
[
0,
117
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29008
|
split_0_train_29008
|
[
{
"id": "split_0_train_29008_passage",
"type": "progene_text",
"text": [
"These results suggest that Gal3ST-4 is the fourth member of a Gal : --> 3 - sulfotransferase family and that the four members , Gal3ST-1 , Gal3ST-2 , Gal3ST-3 , and Gal3ST-4 , are responsible for sulfation of different acceptor substrates ."
],
"offsets": [
[
0,
240
]
]
}
] |
[
{
"id": "split_0_train_47148_entity",
"type": "progene_text",
"text": [
"Gal3ST-4"
],
"offsets": [
[
27,
35
]
],
"normalized": []
},
{
"id": "split_0_train_47149_entity",
"type": "progene_text",
"text": [
"Gal : --> 3 - sulfotransferase family"
],
"offsets": [
[
62,
99
]
],
"normalized": []
},
{
"id": "split_0_train_47150_entity",
"type": "progene_text",
"text": [
"Gal3ST-1"
],
"offsets": [
[
128,
136
]
],
"normalized": []
},
{
"id": "split_0_train_47151_entity",
"type": "progene_text",
"text": [
"Gal3ST-2"
],
"offsets": [
[
139,
147
]
],
"normalized": []
},
{
"id": "split_0_train_47152_entity",
"type": "progene_text",
"text": [
"Gal3ST-3"
],
"offsets": [
[
150,
158
]
],
"normalized": []
},
{
"id": "split_0_train_47153_entity",
"type": "progene_text",
"text": [
"Gal3ST-4"
],
"offsets": [
[
165,
173
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29009
|
split_0_train_29009
|
[
{
"id": "split_0_train_29009_passage",
"type": "progene_text",
"text": [
"Control of electron transfer in neuronal NO synthase ."
],
"offsets": [
[
0,
54
]
]
}
] |
[
{
"id": "split_0_train_47154_entity",
"type": "progene_text",
"text": [
"neuronal NO synthase"
],
"offsets": [
[
32,
52
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29010
|
split_0_train_29010
|
[
{
"id": "split_0_train_29010_passage",
"type": "progene_text",
"text": [
"The nitric oxide synthases ( NOSs ) are dimeric flavocytochromes consisting of an oxygenase domain with cytochrome P450 - like Cys - ligated haem , coupled to a diflavin reductase domain , which is related to cytochrome P450 reductase ."
],
"offsets": [
[
0,
236
]
]
}
] |
[
{
"id": "split_0_train_47155_entity",
"type": "progene_text",
"text": [
"nitric oxide synthases"
],
"offsets": [
[
4,
26
]
],
"normalized": []
},
{
"id": "split_0_train_47156_entity",
"type": "progene_text",
"text": [
"NOSs"
],
"offsets": [
[
29,
33
]
],
"normalized": []
},
{
"id": "split_0_train_47157_entity",
"type": "progene_text",
"text": [
"oxygenase"
],
"offsets": [
[
82,
91
]
],
"normalized": []
},
{
"id": "split_0_train_47158_entity",
"type": "progene_text",
"text": [
"cytochrome P450"
],
"offsets": [
[
104,
119
]
],
"normalized": []
},
{
"id": "split_0_train_47159_entity",
"type": "progene_text",
"text": [
"reductase"
],
"offsets": [
[
170,
179
]
],
"normalized": []
},
{
"id": "split_0_train_47160_entity",
"type": "progene_text",
"text": [
"cytochrome P450 reductase"
],
"offsets": [
[
209,
234
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29011
|
split_0_train_29011
|
[
{
"id": "split_0_train_29011_passage",
"type": "progene_text",
"text": [
"The NOSs catalyse the sequential mono - oxygenation of arginine to N-hydroxyarginine and then to citrulline and NO ."
],
"offsets": [
[
0,
116
]
]
}
] |
[
{
"id": "split_0_train_47161_entity",
"type": "progene_text",
"text": [
"NOSs"
],
"offsets": [
[
4,
8
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29012
|
split_0_train_29012
|
[
{
"id": "split_0_train_29012_passage",
"type": "progene_text",
"text": [
"The constitutive NOS isoforms ( cNOSs ) are regulated by calmodulin ( CaM ) , which binds at elevated concentrations of free Ca(2+) , whereas the inducible isoform binds CaM irreversibly ."
],
"offsets": [
[
0,
188
]
]
}
] |
[
{
"id": "split_0_train_47162_entity",
"type": "progene_text",
"text": [
"constitutive NOS"
],
"offsets": [
[
4,
20
]
],
"normalized": []
},
{
"id": "split_0_train_47163_entity",
"type": "progene_text",
"text": [
"cNOSs"
],
"offsets": [
[
32,
37
]
],
"normalized": []
},
{
"id": "split_0_train_47164_entity",
"type": "progene_text",
"text": [
"calmodulin"
],
"offsets": [
[
57,
67
]
],
"normalized": []
},
{
"id": "split_0_train_47165_entity",
"type": "progene_text",
"text": [
"CaM"
],
"offsets": [
[
70,
73
]
],
"normalized": []
},
{
"id": "split_0_train_47166_entity",
"type": "progene_text",
"text": [
"CaM"
],
"offsets": [
[
170,
173
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29013
|
split_0_train_29013
|
[
{
"id": "split_0_train_29013_passage",
"type": "progene_text",
"text": [
"One of the main structural differences between the constitutive and inducible isoforms is an insert of 40 - 50 amino acids in the FMN - binding domain of the cNOSs ."
],
"offsets": [
[
0,
165
]
]
}
] |
[
{
"id": "split_0_train_47167_entity",
"type": "progene_text",
"text": [
"cNOSs"
],
"offsets": [
[
158,
163
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29014
|
split_0_train_29014
|
[
{
"id": "split_0_train_29014_passage",
"type": "progene_text",
"text": [
"Deletion of the insert in rat neuronal NOS ( nNOS ) led to a mutant enzyme which binds CaM at lower Ca(2+) concentrations and which retains activity in the absence of CaM ."
],
"offsets": [
[
0,
172
]
]
}
] |
[
{
"id": "split_0_train_47168_entity",
"type": "progene_text",
"text": [
"neuronal NOS"
],
"offsets": [
[
30,
42
]
],
"normalized": []
},
{
"id": "split_0_train_47169_entity",
"type": "progene_text",
"text": [
"nNOS"
],
"offsets": [
[
45,
49
]
],
"normalized": []
},
{
"id": "split_0_train_47170_entity",
"type": "progene_text",
"text": [
"CaM"
],
"offsets": [
[
87,
90
]
],
"normalized": []
},
{
"id": "split_0_train_47171_entity",
"type": "progene_text",
"text": [
"CaM"
],
"offsets": [
[
167,
170
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29015
|
split_0_train_29015
|
[
{
"id": "split_0_train_29015_passage",
"type": "progene_text",
"text": [
"In order to resolve the mechanism of action of CaM activation we determined reduction potentials for the FMN and FAD cofactors of rat nNOS in the presence and absence of CaM using a recombinant form of the reductase domain ."
],
"offsets": [
[
0,
224
]
]
}
] |
[
{
"id": "split_0_train_47172_entity",
"type": "progene_text",
"text": [
"CaM"
],
"offsets": [
[
47,
50
]
],
"normalized": []
},
{
"id": "split_0_train_47173_entity",
"type": "progene_text",
"text": [
"nNOS"
],
"offsets": [
[
134,
138
]
],
"normalized": []
},
{
"id": "split_0_train_47174_entity",
"type": "progene_text",
"text": [
"CaM"
],
"offsets": [
[
170,
173
]
],
"normalized": []
},
{
"id": "split_0_train_47175_entity",
"type": "progene_text",
"text": [
"reductase"
],
"offsets": [
[
206,
215
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29016
|
split_0_train_29016
|
[
{
"id": "split_0_train_29016_passage",
"type": "progene_text",
"text": [
"The results indicate that CaM binding does not modulate the reduction potentials of the flavins , but appears to control electron transfer primarily via a large structural rearrangement ."
],
"offsets": [
[
0,
187
]
]
}
] |
[
{
"id": "split_0_train_47176_entity",
"type": "progene_text",
"text": [
"CaM"
],
"offsets": [
[
26,
29
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29017
|
split_0_train_29017
|
[
{
"id": "split_0_train_29017_passage",
"type": "progene_text",
"text": [
"We also report the creation of chimaeric enzymes in which the reductase domains of nNOS and flavocytochrome P450 BM3 ( Bacillus megaterium III ) have been exchanged ."
],
"offsets": [
[
0,
166
]
]
}
] |
[
{
"id": "split_0_train_47177_entity",
"type": "progene_text",
"text": [
"reductase"
],
"offsets": [
[
62,
71
]
],
"normalized": []
},
{
"id": "split_0_train_47178_entity",
"type": "progene_text",
"text": [
"nNOS"
],
"offsets": [
[
83,
87
]
],
"normalized": []
},
{
"id": "split_0_train_47179_entity",
"type": "progene_text",
"text": [
"flavocytochrome P450 BM3"
],
"offsets": [
[
92,
116
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29018
|
split_0_train_29018
|
[
{
"id": "split_0_train_29018_passage",
"type": "progene_text",
"text": [
"Despite its very different flavin redox potentials , the BM3 reductase domain was able to support low levels of CaM - dependent NO synthesis , whereas the NOS reductase domain did not effectively substitute for that of cytochrome P450 BM3 ."
],
"offsets": [
[
0,
240
]
]
}
] |
[
{
"id": "split_0_train_47180_entity",
"type": "progene_text",
"text": [
"BM3 reductase"
],
"offsets": [
[
57,
70
]
],
"normalized": []
},
{
"id": "split_0_train_47181_entity",
"type": "progene_text",
"text": [
"CaM"
],
"offsets": [
[
112,
115
]
],
"normalized": []
},
{
"id": "split_0_train_47182_entity",
"type": "progene_text",
"text": [
"NOS reductase"
],
"offsets": [
[
155,
168
]
],
"normalized": []
},
{
"id": "split_0_train_47183_entity",
"type": "progene_text",
"text": [
"cytochrome P450 BM3"
],
"offsets": [
[
219,
238
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29019
|
split_0_train_29019
|
[
{
"id": "split_0_train_29019_passage",
"type": "progene_text",
"text": [
"Induction of 11beta-hydroxysteroid dehydrogenase type 1 but not - 2 in human aortic smooth muscle cells by inflammatory stimuli ."
],
"offsets": [
[
0,
129
]
]
}
] |
[
{
"id": "split_0_train_47184_entity",
"type": "progene_text",
"text": [
"11beta-hydroxysteroid dehydrogenase type 1 but not - 2"
],
"offsets": [
[
13,
67
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29020
|
split_0_train_29020
|
[
{
"id": "split_0_train_29020_passage",
"type": "progene_text",
"text": [
"The 11beta-hydroxysteroid dehydrogenase ( 11beta-HSD ) enzymes catalyze the interconversion of active glucocorticoids ( GC ) with their inert metabolites , thereby regulating the functional activity of GC ."
],
"offsets": [
[
0,
206
]
]
}
] |
[
{
"id": "split_0_train_47185_entity",
"type": "progene_text",
"text": [
"11beta-hydroxysteroid dehydrogenase"
],
"offsets": [
[
4,
39
]
],
"normalized": []
},
{
"id": "split_0_train_47186_entity",
"type": "progene_text",
"text": [
"11beta-HSD"
],
"offsets": [
[
42,
52
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29021
|
split_0_train_29021
|
[
{
"id": "split_0_train_29021_passage",
"type": "progene_text",
"text": [
"While 11beta-HSD type 1 ( 11beta-HSD1 ) activates GC from their 11-keto metabolites , 11beta-HSD type 2 ( 11beta-HSD2 ) inactivates GC ."
],
"offsets": [
[
0,
136
]
]
}
] |
[
{
"id": "split_0_train_47187_entity",
"type": "progene_text",
"text": [
"11beta-HSD type 1"
],
"offsets": [
[
6,
23
]
],
"normalized": []
},
{
"id": "split_0_train_47188_entity",
"type": "progene_text",
"text": [
"11beta-HSD1"
],
"offsets": [
[
26,
37
]
],
"normalized": []
},
{
"id": "split_0_train_47189_entity",
"type": "progene_text",
"text": [
"11beta-HSD type 2"
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[] |
split_0_train_29022
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split_0_train_29022
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[] |
split_0_train_29023
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split_0_train_29023
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[] |
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[] |
split_0_train_29024
|
split_0_train_29024
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[] |
split_0_train_29025
|
split_0_train_29025
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"A similar increase of 11beta-HSD1 mRNA expression was also found in human bronchial SMC upon stimulation , indicating the regulatory effect is not limited to vascular smooth muscle ."
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[] |
[] |
split_0_train_29026
|
split_0_train_29026
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[] |
[] |
split_0_train_29027
|
split_0_train_29027
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[] |
[] |
[] |
split_0_train_29028
|
split_0_train_29028
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44,
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[] |
[] |
[] |
split_0_train_29029
|
split_0_train_29029
|
[
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112
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[] |
[] |
[] |
[] |
split_0_train_29030
|
split_0_train_29030
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[] |
[] |
[] |
split_0_train_29031
|
split_0_train_29031
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[] |
[] |
[] |
split_0_train_29032
|
split_0_train_29032
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"text": [
"The size of the cDNA is consistent with its estimated mRNA size ."
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] |
[] |
[] |
[] |
[] |
split_0_train_29033
|
split_0_train_29033
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[
{
"id": "split_0_train_29033_passage",
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[] |
[] |
[] |
split_0_train_29034
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split_0_train_29034
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219,
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] |
[] |
[] |
[] |
split_0_train_29035
|
split_0_train_29035
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"type": "progene_text",
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96,
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] |
[] |
[] |
[] |
split_0_train_29036
|
split_0_train_29036
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[] |
[] |
[] |
split_0_train_29037
|
split_0_train_29037
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[
{
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82,
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[] |
[] |
[] |
split_0_train_29038
|
split_0_train_29038
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128,
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[] |
[] |
[] |
split_0_train_29039
|
split_0_train_29039
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[] |
[] |
[] |
[] |
split_0_train_29040
|
split_0_train_29040
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{
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[] |
[] |
[] |
split_0_train_29041
|
split_0_train_29041
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[] |
[] |
[] |
split_0_train_29042
|
split_0_train_29042
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[] |
[] |
[] |
split_0_train_29043
|
split_0_train_29043
|
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[] |
[] |
[] |
split_0_train_29044
|
split_0_train_29044
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85,
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[] |
[] |
[] |
split_0_train_29045
|
split_0_train_29045
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"The cAMP receptor protein ( CRP ; sometimes known as CAP , the catabolite gene activator protein ) and the fumarate and nitrate reduction regulator ( FNR ) of Escherichia coli are founder members of an expanding superfamily of structurally related transcription factors ."
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{
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248,
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[] |
[] |
[] |
split_0_train_29046
|
split_0_train_29046
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[
{
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155
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15,
18
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29047
|
split_0_train_29047
|
[
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"id": "split_0_train_29047_passage",
"type": "progene_text",
"text": [
"It allows different functional specificities at the sensory , DNA - recognition and RNA - polymerase - interaction levels to be ' mixed and matched ' in order to create a diverse range of transcription factors tailored to respond to particular physiological conditions ."
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[
0,
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]
}
] |
[
{
"id": "split_0_train_47244_entity",
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84,
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"id": "split_0_train_47245_entity",
"type": "progene_text",
"text": [
"transcription factors"
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[
188,
209
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],
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}
] |
[] |
[] |
[] |
split_0_train_29048
|
split_0_train_29048
|
[
{
"id": "split_0_train_29048_passage",
"type": "progene_text",
"text": [
"This versatility is clearly illustrated by comparing the properties of the CRP , FNR and FLP ( FNR - like protein ) regulators ."
],
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[
0,
128
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]
}
] |
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{
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"type": "progene_text",
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"text": [
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{
"id": "split_0_train_47248_entity",
"type": "progene_text",
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{
"id": "split_0_train_47249_entity",
"type": "progene_text",
"text": [
"FNR - like protein"
],
"offsets": [
[
95,
113
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29049
|
split_0_train_29049
|
[
{
"id": "split_0_train_29049_passage",
"type": "progene_text",
"text": [
"At the sensory level , the basic structural fold has been adapted in FNR and FLP by the acquisition in the N - terminal region of different combinations of cysteine or other residues ; which bestow oxygen / redox sensing mechanisms that are poised according to the oxidative stress thresholds affecting the metabolism of specific bacteria ."
],
"offsets": [
[
0,
340
]
]
}
] |
[
{
"id": "split_0_train_47250_entity",
"type": "progene_text",
"text": [
"FNR"
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69,
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{
"id": "split_0_train_47251_entity",
"type": "progene_text",
"text": [
"FLP"
],
"offsets": [
[
77,
80
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29050
|
split_0_train_29050
|
[
{
"id": "split_0_train_29050_passage",
"type": "progene_text",
"text": [
"At the DNA - recognition level , discrimination between distinct but related DNA targets is mediated by amino acid sequence modifications in the conserved core contact between the DNA - recognition helix and target DNA ."
],
"offsets": [
[
0,
220
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29051
|
split_0_train_29051
|
[
{
"id": "split_0_train_29051_passage",
"type": "progene_text",
"text": [
"And , at the level of RNA - polymerase - interaction , different combinations of three discrete regions contacting the polymerase ( the activating regions ) are used for polymerase recruitment and promoting transcription ."
],
"offsets": [
[
0,
222
]
]
}
] |
[
{
"id": "split_0_train_47252_entity",
"type": "progene_text",
"text": [
"RNA - polymerase"
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22,
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{
"id": "split_0_train_47253_entity",
"type": "progene_text",
"text": [
"polymerase"
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119,
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{
"id": "split_0_train_47254_entity",
"type": "progene_text",
"text": [
"polymerase"
],
"offsets": [
[
170,
180
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29052
|
split_0_train_29052
|
[
{
"id": "split_0_train_29052_passage",
"type": "progene_text",
"text": [
"Mutations of the beta - and gamma - catenin genes are uncommon in human lung , breast , kidney , cervical and ovarian carcinomas ."
],
"offsets": [
[
0,
130
]
]
}
] |
[
{
"id": "split_0_train_47255_entity",
"type": "progene_text",
"text": [
"beta - and gamma - catenin"
],
"offsets": [
[
17,
43
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29053
|
split_0_train_29053
|
[
{
"id": "split_0_train_29053_passage",
"type": "progene_text",
"text": [
"Beta-catenin forms complexes with Tcf and Lef-1 and functions as a transcriptional activator in the Wnt signalling pathway ."
],
"offsets": [
[
0,
124
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]
}
] |
[
{
"id": "split_0_train_47256_entity",
"type": "progene_text",
"text": [
"Beta-catenin"
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0,
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{
"id": "split_0_train_47257_entity",
"type": "progene_text",
"text": [
"Tcf"
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34,
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{
"id": "split_0_train_47258_entity",
"type": "progene_text",
"text": [
"Lef-1"
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42,
47
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{
"id": "split_0_train_47259_entity",
"type": "progene_text",
"text": [
"Wnt"
],
"offsets": [
[
100,
103
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29054
|
split_0_train_29054
|
[
{
"id": "split_0_train_29054_passage",
"type": "progene_text",
"text": [
"Although recent investigations have been focused on the role of the adenomatous polyposis coli ( APC ) / beta-catenin / Tcf pathway in human tumorigenesis , there have been very few reports on mutations of the beta-catenin gene in a variety of tumour types ."
],
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[
0,
258
]
]
}
] |
[
{
"id": "split_0_train_47260_entity",
"type": "progene_text",
"text": [
"adenomatous polyposis coli"
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68,
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{
"id": "split_0_train_47261_entity",
"type": "progene_text",
"text": [
"APC"
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97,
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{
"id": "split_0_train_47262_entity",
"type": "progene_text",
"text": [
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105,
117
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{
"id": "split_0_train_47263_entity",
"type": "progene_text",
"text": [
"Tcf"
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120,
123
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{
"id": "split_0_train_47264_entity",
"type": "progene_text",
"text": [
"beta-catenin"
],
"offsets": [
[
210,
222
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29055
|
split_0_train_29055
|
[
{
"id": "split_0_train_29055_passage",
"type": "progene_text",
"text": [
"Using PCR and single - strand conformational polymorphism analysis , we examined 93 lung , 9 breast , 6 kidney , 19 cervical and 7 ovarian carcinoma cell lines for mutations in exon 3 of the beta - catenin gene ."
],
"offsets": [
[
0,
212
]
]
}
] |
[
{
"id": "split_0_train_47265_entity",
"type": "progene_text",
"text": [
"beta - catenin"
],
"offsets": [
[
191,
205
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29056
|
split_0_train_29056
|
[
{
"id": "split_0_train_29056_passage",
"type": "progene_text",
"text": [
"In addition , we tested these same samples for mutations in the NH2 - terminal regulatory region of the gamma-catenin gene ."
],
"offsets": [
[
0,
124
]
]
}
] |
[
{
"id": "split_0_train_47266_entity",
"type": "progene_text",
"text": [
"gamma-catenin"
],
"offsets": [
[
104,
117
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29057
|
split_0_train_29057
|
[
{
"id": "split_0_train_29057_passage",
"type": "progene_text",
"text": [
"Mutational analysis for the entire coding region of beta-catenin cDNA was also undertaken in 20 lung , 9 breast , 5 kidney and 6 cervical carcinoma cell lines ."
],
"offsets": [
[
0,
160
]
]
}
] |
[
{
"id": "split_0_train_47267_entity",
"type": "progene_text",
"text": [
"beta-catenin"
],
"offsets": [
[
52,
64
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29058
|
split_0_train_29058
|
[
{
"id": "split_0_train_29058_passage",
"type": "progene_text",
"text": [
"Deletion of most beta-catenin coding exons was confirmed in line NCI-H28 ( lung mesothelioma ) and a silent mutation at codon 214 in exon 5 was found in HeLa ( cervical adenocarcinoma ) ."
],
"offsets": [
[
0,
187
]
]
}
] |
[
{
"id": "split_0_train_47268_entity",
"type": "progene_text",
"text": [
"beta-catenin"
],
"offsets": [
[
17,
29
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29059
|
split_0_train_29059
|
[
{
"id": "split_0_train_29059_passage",
"type": "progene_text",
"text": [
"A missense mutation at codon 19 and a silent mutation at codon 28 in the NH2 - terminal regulatory region of the gamma-catenin gene were found in H1726 ( squamous cell lung carcinoma ) and H1048 ( small cell lung carcinoma ) , respectively ."
],
"offsets": [
[
0,
241
]
]
}
] |
[
{
"id": "split_0_train_47269_entity",
"type": "progene_text",
"text": [
"gamma-catenin"
],
"offsets": [
[
113,
126
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29060
|
split_0_train_29060
|
[
{
"id": "split_0_train_29060_passage",
"type": "progene_text",
"text": [
"Neither deletions nor mutations of these genes were detected in the other cell lines examined ."
],
"offsets": [
[
0,
95
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29061
|
split_0_train_29061
|
[
{
"id": "split_0_train_29061_passage",
"type": "progene_text",
"text": [
"These results suggest that beta - and gamma - catenins are infrequent mutational targets during development of human lung , breast , kidney , cervical and ovarian carcinomas ."
],
"offsets": [
[
0,
175
]
]
}
] |
[
{
"id": "split_0_train_47270_entity",
"type": "progene_text",
"text": [
"beta - and gamma - catenins"
],
"offsets": [
[
27,
54
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29062
|
split_0_train_29062
|
[
{
"id": "split_0_train_29062_passage",
"type": "progene_text",
"text": [
"Astrocyte differentiation of fetal neuroepithelial cells involving cardiotrophin-1 - induced activation of STAT3 ."
],
"offsets": [
[
0,
114
]
]
}
] |
[
{
"id": "split_0_train_47271_entity",
"type": "progene_text",
"text": [
"cardiotrophin-1"
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"offsets": [
[
67,
82
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"normalized": []
},
{
"id": "split_0_train_47272_entity",
"type": "progene_text",
"text": [
"STAT3"
],
"offsets": [
[
107,
112
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29063
|
split_0_train_29063
|
[
{
"id": "split_0_train_29063_passage",
"type": "progene_text",
"text": [
"Cardiotrophin-1 ( CT-1 ) belongs to the interleukin ( IL-) 6 family of cytokines that share membrane glycoprotein 130 ( gp130 ) as a receptor component critical for signal transduction ."
],
"offsets": [
[
0,
186
]
]
}
] |
[
{
"id": "split_0_train_47273_entity",
"type": "progene_text",
"text": [
"Cardiotrophin-1"
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"offsets": [
[
0,
15
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],
"normalized": []
},
{
"id": "split_0_train_47274_entity",
"type": "progene_text",
"text": [
"CT-1"
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18,
22
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],
"normalized": []
},
{
"id": "split_0_train_47275_entity",
"type": "progene_text",
"text": [
"interleukin ( IL-) 6 family of cytokines"
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"offsets": [
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40,
80
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],
"normalized": []
},
{
"id": "split_0_train_47276_entity",
"type": "progene_text",
"text": [
"glycoprotein 130"
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"offsets": [
[
101,
117
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],
"normalized": []
},
{
"id": "split_0_train_47277_entity",
"type": "progene_text",
"text": [
"gp130"
],
"offsets": [
[
120,
125
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29064
|
split_0_train_29064
|
[
{
"id": "split_0_train_29064_passage",
"type": "progene_text",
"text": [
"We here observed that CT-1 was expressed in mouse fetal neuroepithelial cells , and was capable of inducing astrocyte differentiation from these cells in a synergistic manner with bone morphogenetic protein ( BMP ) - 2 , whose expression was also found in the fetal brain ."
],
"offsets": [
[
0,
273
]
]
}
] |
[
{
"id": "split_0_train_47278_entity",
"type": "progene_text",
"text": [
"CT-1"
],
"offsets": [
[
22,
26
]
],
"normalized": []
},
{
"id": "split_0_train_47279_entity",
"type": "progene_text",
"text": [
"bone morphogenetic protein ( BMP ) - 2"
],
"offsets": [
[
180,
218
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29065
|
split_0_train_29065
|
[
{
"id": "split_0_train_29065_passage",
"type": "progene_text",
"text": [
"CT-1 - induced astrocyte differentiation was solely gp130 - dependent ."
],
"offsets": [
[
0,
71
]
]
}
] |
[
{
"id": "split_0_train_47280_entity",
"type": "progene_text",
"text": [
"CT-1"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_47281_entity",
"type": "progene_text",
"text": [
"gp130"
],
"offsets": [
[
52,
57
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29066
|
split_0_train_29066
|
[
{
"id": "split_0_train_29066_passage",
"type": "progene_text",
"text": [
"CT-1 - stimulation led to promoter activation of the gene for an astrocyte marker , glial fibrillary acidic protein ( GFAP ) , which was clearly inhibited by expression of a dominant negative form of a gp130 - downstream transcription factor , signal transducer and activator of transcription 3 ( STAT3 ) , or by introduction of a mutation in a single STAT3 - binding site in the promoter , suggesting a critical role of STAT3 in the CT-1 - induced GFAP transcription ."
],
"offsets": [
[
0,
469
]
]
}
] |
[
{
"id": "split_0_train_47282_entity",
"type": "progene_text",
"text": [
"CT-1"
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"offsets": [
[
0,
4
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],
"normalized": []
},
{
"id": "split_0_train_47283_entity",
"type": "progene_text",
"text": [
"glial fibrillary acidic protein"
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"offsets": [
[
84,
115
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"normalized": []
},
{
"id": "split_0_train_47284_entity",
"type": "progene_text",
"text": [
"GFAP"
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"offsets": [
[
118,
122
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"normalized": []
},
{
"id": "split_0_train_47285_entity",
"type": "progene_text",
"text": [
"gp130"
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"offsets": [
[
202,
207
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],
"normalized": []
},
{
"id": "split_0_train_47286_entity",
"type": "progene_text",
"text": [
"transcription factor"
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"offsets": [
[
221,
241
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],
"normalized": []
},
{
"id": "split_0_train_47287_entity",
"type": "progene_text",
"text": [
"signal transducer and activator of transcription 3"
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"offsets": [
[
244,
294
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],
"normalized": []
},
{
"id": "split_0_train_47288_entity",
"type": "progene_text",
"text": [
"STAT3"
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"offsets": [
[
297,
302
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],
"normalized": []
},
{
"id": "split_0_train_47289_entity",
"type": "progene_text",
"text": [
"STAT3"
],
"offsets": [
[
352,
357
]
],
"normalized": []
},
{
"id": "split_0_train_47290_entity",
"type": "progene_text",
"text": [
"STAT3"
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"offsets": [
[
421,
426
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],
"normalized": []
},
{
"id": "split_0_train_47291_entity",
"type": "progene_text",
"text": [
"CT-1"
],
"offsets": [
[
434,
438
]
],
"normalized": []
},
{
"id": "split_0_train_47292_entity",
"type": "progene_text",
"text": [
"GFAP"
],
"offsets": [
[
449,
453
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29067
|
split_0_train_29067
|
[
{
"id": "split_0_train_29067_passage",
"type": "progene_text",
"text": [
"These results suggest that astrocyte differentiation in the developing brain involves CT-1 - signaling which cooperates with BMP2 ."
],
"offsets": [
[
0,
131
]
]
}
] |
[
{
"id": "split_0_train_47293_entity",
"type": "progene_text",
"text": [
"CT-1"
],
"offsets": [
[
86,
90
]
],
"normalized": []
},
{
"id": "split_0_train_47294_entity",
"type": "progene_text",
"text": [
"BMP2"
],
"offsets": [
[
125,
129
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29068
|
split_0_train_29068
|
[
{
"id": "split_0_train_29068_passage",
"type": "progene_text",
"text": [
"Escherichia coli SecA helicase activity is not required in vivo for efficient protein translocation or autogenous regulation ."
],
"offsets": [
[
0,
126
]
]
}
] |
[
{
"id": "split_0_train_47295_entity",
"type": "progene_text",
"text": [
"SecA"
],
"offsets": [
[
17,
21
]
],
"normalized": []
},
{
"id": "split_0_train_47296_entity",
"type": "progene_text",
"text": [
"helicase"
],
"offsets": [
[
22,
30
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29069
|
split_0_train_29069
|
[
{
"id": "split_0_train_29069_passage",
"type": "progene_text",
"text": [
"SecA is an essential ATP - driven motor protein that binds to preproteins and the translocon to promote protein translocation across the eubacterial plasma membrane ."
],
"offsets": [
[
0,
166
]
]
}
] |
[
{
"id": "split_0_train_47297_entity",
"type": "progene_text",
"text": [
"SecA"
],
"offsets": [
[
0,
4
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29070
|
split_0_train_29070
|
[
{
"id": "split_0_train_29070_passage",
"type": "progene_text",
"text": [
"Escherichia coli SecA contains seven conserved motifs characteristic of superfamily II of DNA and RNA helicases , and it has been shown previously to possess RNA helicase activity ."
],
"offsets": [
[
0,
181
]
]
}
] |
[
{
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"type": "progene_text",
"text": [
"RNA helicase"
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[
158,
170
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],
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}
] |
[] |
[] |
[] |
split_0_train_29071
|
split_0_train_29071
|
[
{
"id": "split_0_train_29071_passage",
"type": "progene_text",
"text": [
"SecA has also been shown to be an autogenous repressor that binds to its translation initiation region on secM - secA mRNA , thereby blocking and dissociating 30 S ribosomal subunits ."
],
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[
0,
184
]
]
}
] |
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{
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{
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"type": "progene_text",
"text": [
"secA"
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"offsets": [
[
113,
117
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29072
|
split_0_train_29072
|
[
{
"id": "split_0_train_29072_passage",
"type": "progene_text",
"text": [
"Here we show that SecA is an ATP - dependent helicase that unwinds a mimic of the repressor helix of secM - secA mRNA ."
],
"offsets": [
[
0,
119
]
]
}
] |
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{
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18,
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{
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"text": [
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45,
53
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{
"id": "split_0_train_47306_entity",
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101,
105
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{
"id": "split_0_train_47307_entity",
"type": "progene_text",
"text": [
"secA"
],
"offsets": [
[
108,
112
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29073
|
split_0_train_29073
|
[
{
"id": "split_0_train_29073_passage",
"type": "progene_text",
"text": [
"Mutational analysis of the seven conserved helicase motifs in SecA allowed us to identify mutants that uncouple SecA - dependent protein translocation activity from its helicase activity ."
],
"offsets": [
[
0,
188
]
]
}
] |
[
{
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43,
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{
"id": "split_0_train_47310_entity",
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"SecA"
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112,
116
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{
"id": "split_0_train_47311_entity",
"type": "progene_text",
"text": [
"helicase"
],
"offsets": [
[
169,
177
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29074
|
split_0_train_29074
|
[
{
"id": "split_0_train_29074_passage",
"type": "progene_text",
"text": [
"Helicase - defective secA mutants displayed normal protein translocation activity and autogenous repression of secA in vivo ."
],
"offsets": [
[
0,
125
]
]
}
] |
[
{
"id": "split_0_train_47312_entity",
"type": "progene_text",
"text": [
"Helicase"
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[
0,
8
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{
"id": "split_0_train_47313_entity",
"type": "progene_text",
"text": [
"secA"
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21,
25
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{
"id": "split_0_train_47314_entity",
"type": "progene_text",
"text": [
"secA"
],
"offsets": [
[
111,
115
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29075
|
split_0_train_29075
|
[
{
"id": "split_0_train_29075_passage",
"type": "progene_text",
"text": [
"Our studies indicate that SecA helicase activity is nonessential and does not appear to be necessary for efficient protein secretion and secA autoregulation ."
],
"offsets": [
[
0,
158
]
]
}
] |
[
{
"id": "split_0_train_47315_entity",
"type": "progene_text",
"text": [
"SecA"
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"offsets": [
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26,
30
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},
{
"id": "split_0_train_47316_entity",
"type": "progene_text",
"text": [
"helicase"
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31,
39
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],
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},
{
"id": "split_0_train_47317_entity",
"type": "progene_text",
"text": [
"secA"
],
"offsets": [
[
137,
141
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29076
|
split_0_train_29076
|
[
{
"id": "split_0_train_29076_passage",
"type": "progene_text",
"text": [
"Evidence for a novel thrombopoietin signalling event : activation of protein kinase A in human megakaryoblastic CMK cells ."
],
"offsets": [
[
0,
123
]
]
}
] |
[
{
"id": "split_0_train_47318_entity",
"type": "progene_text",
"text": [
"thrombopoietin"
],
"offsets": [
[
21,
35
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],
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},
{
"id": "split_0_train_47319_entity",
"type": "progene_text",
"text": [
"protein kinase A"
],
"offsets": [
[
69,
85
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29077
|
split_0_train_29077
|
[
{
"id": "split_0_train_29077_passage",
"type": "progene_text",
"text": [
"Thrombopoietin ( TPO ) plays a crucial role in megakaryocyte development ."
],
"offsets": [
[
0,
74
]
]
}
] |
[
{
"id": "split_0_train_47320_entity",
"type": "progene_text",
"text": [
"Thrombopoietin"
],
"offsets": [
[
0,
14
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],
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},
{
"id": "split_0_train_47321_entity",
"type": "progene_text",
"text": [
"TPO"
],
"offsets": [
[
17,
20
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29078
|
split_0_train_29078
|
[
{
"id": "split_0_train_29078_passage",
"type": "progene_text",
"text": [
"TPO signalling , which is mediated by its receptor Mpl , includes Janus kinase , ( JAK ) signal transducer and activator of transcription ( STAT ) and Shc / Ras / mitogen - activated protein kinase ( MAPK ) pathways ."
],
"offsets": [
[
0,
217
]
]
}
] |
[
{
"id": "split_0_train_47322_entity",
"type": "progene_text",
"text": [
"TPO"
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"offsets": [
[
0,
3
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],
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},
{
"id": "split_0_train_47323_entity",
"type": "progene_text",
"text": [
"Mpl"
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[
51,
54
]
],
"normalized": []
},
{
"id": "split_0_train_47324_entity",
"type": "progene_text",
"text": [
"Janus kinase"
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"offsets": [
[
66,
78
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],
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},
{
"id": "split_0_train_47325_entity",
"type": "progene_text",
"text": [
"JAK"
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83,
86
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],
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},
{
"id": "split_0_train_47326_entity",
"type": "progene_text",
"text": [
"signal transducer and activator of transcription"
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89,
137
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],
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},
{
"id": "split_0_train_47327_entity",
"type": "progene_text",
"text": [
"STAT"
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[
140,
144
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],
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},
{
"id": "split_0_train_47328_entity",
"type": "progene_text",
"text": [
"Shc"
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[
151,
154
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],
"normalized": []
},
{
"id": "split_0_train_47329_entity",
"type": "progene_text",
"text": [
"Ras"
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[
157,
160
]
],
"normalized": []
},
{
"id": "split_0_train_47330_entity",
"type": "progene_text",
"text": [
"mitogen - activated protein kinase"
],
"offsets": [
[
163,
197
]
],
"normalized": []
},
{
"id": "split_0_train_47331_entity",
"type": "progene_text",
"text": [
"MAPK"
],
"offsets": [
[
200,
204
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29079
|
split_0_train_29079
|
[
{
"id": "split_0_train_29079_passage",
"type": "progene_text",
"text": [
"The precise nature of these signalling routes has not been clarified in detail up until now ."
],
"offsets": [
[
0,
93
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29080
|
split_0_train_29080
|
[
{
"id": "split_0_train_29080_passage",
"type": "progene_text",
"text": [
"We investigated the effect of TPO on activation of cAMP - dependent protein kinase ( PKA ) and its involvement in MAPK signalling in human megakaryoblastic leukaemia CMK cells ."
],
"offsets": [
[
0,
177
]
]
}
] |
[
{
"id": "split_0_train_47332_entity",
"type": "progene_text",
"text": [
"TPO"
],
"offsets": [
[
30,
33
]
],
"normalized": []
},
{
"id": "split_0_train_47333_entity",
"type": "progene_text",
"text": [
"cAMP - dependent protein kinase"
],
"offsets": [
[
51,
82
]
],
"normalized": []
},
{
"id": "split_0_train_47334_entity",
"type": "progene_text",
"text": [
"PKA"
],
"offsets": [
[
85,
88
]
],
"normalized": []
},
{
"id": "split_0_train_47335_entity",
"type": "progene_text",
"text": [
"MAPK"
],
"offsets": [
[
114,
118
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29081
|
split_0_train_29081
|
[
{
"id": "split_0_train_29081_passage",
"type": "progene_text",
"text": [
"For estimation of PKA activity , phosphorylation of a PKA - specific peptide substrate was assayed in CMK cell lysates ."
],
"offsets": [
[
0,
120
]
]
}
] |
[
{
"id": "split_0_train_47336_entity",
"type": "progene_text",
"text": [
"PKA"
],
"offsets": [
[
18,
21
]
],
"normalized": []
},
{
"id": "split_0_train_47337_entity",
"type": "progene_text",
"text": [
"PKA"
],
"offsets": [
[
54,
57
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29082
|
split_0_train_29082
|
[
{
"id": "split_0_train_29082_passage",
"type": "progene_text",
"text": [
"Since activation of PKA is associated with translocation of its catalytic subunit alpha ( C - PKA ) into the cell nucleus , Western blot analysis of nuclear fractions with an anti - C - PKA antibody was additionally performed ."
],
"offsets": [
[
0,
227
]
]
}
] |
[
{
"id": "split_0_train_47338_entity",
"type": "progene_text",
"text": [
"PKA"
],
"offsets": [
[
20,
23
]
],
"normalized": []
},
{
"id": "split_0_train_47339_entity",
"type": "progene_text",
"text": [
"PKA"
],
"offsets": [
[
94,
97
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],
"normalized": []
},
{
"id": "split_0_train_47340_entity",
"type": "progene_text",
"text": [
"PKA"
],
"offsets": [
[
186,
189
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29083
|
split_0_train_29083
|
[
{
"id": "split_0_train_29083_passage",
"type": "progene_text",
"text": [
"The activation of TPO - induced MAPK activation and the effect of the PKA inhibitor H-89 was measured using immunoblotting with a monoclonal anti - pERK antibody ."
],
"offsets": [
[
0,
163
]
]
}
] |
[
{
"id": "split_0_train_47341_entity",
"type": "progene_text",
"text": [
"TPO"
],
"offsets": [
[
18,
21
]
],
"normalized": []
},
{
"id": "split_0_train_47342_entity",
"type": "progene_text",
"text": [
"MAPK"
],
"offsets": [
[
32,
36
]
],
"normalized": []
},
{
"id": "split_0_train_47343_entity",
"type": "progene_text",
"text": [
"PKA"
],
"offsets": [
[
70,
73
]
],
"normalized": []
},
{
"id": "split_0_train_47344_entity",
"type": "progene_text",
"text": [
"pERK"
],
"offsets": [
[
148,
152
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29084
|
split_0_train_29084
|
[
{
"id": "split_0_train_29084_passage",
"type": "progene_text",
"text": [
"TPO enhanced cAMP and induced activation of PKA in CMK cells ."
],
"offsets": [
[
0,
62
]
]
}
] |
[
{
"id": "split_0_train_47345_entity",
"type": "progene_text",
"text": [
"TPO"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "split_0_train_47346_entity",
"type": "progene_text",
"text": [
"PKA"
],
"offsets": [
[
44,
47
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29085
|
split_0_train_29085
|
[
{
"id": "split_0_train_29085_passage",
"type": "progene_text",
"text": [
"In addition , H-89 partly blocked TPO - induced MAPK activation in CMK cells ."
],
"offsets": [
[
0,
78
]
]
}
] |
[
{
"id": "split_0_train_47347_entity",
"type": "progene_text",
"text": [
"TPO"
],
"offsets": [
[
34,
37
]
],
"normalized": []
},
{
"id": "split_0_train_47348_entity",
"type": "progene_text",
"text": [
"MAPK"
],
"offsets": [
[
48,
52
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29086
|
split_0_train_29086
|
[
{
"id": "split_0_train_29086_passage",
"type": "progene_text",
"text": [
"Our results indicate a novel TPO - triggered signalling event , activation of the cAMP / PKA pathway in human megakaryoblastic CMK cells ."
],
"offsets": [
[
0,
138
]
]
}
] |
[
{
"id": "split_0_train_47349_entity",
"type": "progene_text",
"text": [
"TPO"
],
"offsets": [
[
29,
32
]
],
"normalized": []
},
{
"id": "split_0_train_47350_entity",
"type": "progene_text",
"text": [
"PKA"
],
"offsets": [
[
89,
92
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29087
|
split_0_train_29087
|
[
{
"id": "split_0_train_29087_passage",
"type": "progene_text",
"text": [
"This signal transduction route seems to be involved in TPO - induced MAPK signaling ."
],
"offsets": [
[
0,
85
]
]
}
] |
[
{
"id": "split_0_train_47351_entity",
"type": "progene_text",
"text": [
"TPO"
],
"offsets": [
[
55,
58
]
],
"normalized": []
},
{
"id": "split_0_train_47352_entity",
"type": "progene_text",
"text": [
"MAPK"
],
"offsets": [
[
69,
73
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29088
|
split_0_train_29088
|
[
{
"id": "split_0_train_29088_passage",
"type": "progene_text",
"text": [
"The ASK1 gene regulates B function gene expression in cooperation with UFO and LEAFY in Arabidopsis ."
],
"offsets": [
[
0,
101
]
]
}
] |
[
{
"id": "split_0_train_47353_entity",
"type": "progene_text",
"text": [
"ASK1"
],
"offsets": [
[
4,
8
]
],
"normalized": []
},
{
"id": "split_0_train_47354_entity",
"type": "progene_text",
"text": [
"UFO"
],
"offsets": [
[
71,
74
]
],
"normalized": []
},
{
"id": "split_0_train_47355_entity",
"type": "progene_text",
"text": [
"LEAFY"
],
"offsets": [
[
79,
84
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29089
|
split_0_train_29089
|
[
{
"id": "split_0_train_29089_passage",
"type": "progene_text",
"text": [
"The Arabidopsis floral regulatory genes APETALA3 ( AP3 ) and PISTILLATA ( PI ) are required for the B function according to the ABC model for floral organ identity ."
],
"offsets": [
[
0,
165
]
]
}
] |
[
{
"id": "split_0_train_47356_entity",
"type": "progene_text",
"text": [
"APETALA3"
],
"offsets": [
[
40,
48
]
],
"normalized": []
},
{
"id": "split_0_train_47357_entity",
"type": "progene_text",
"text": [
"AP3"
],
"offsets": [
[
51,
54
]
],
"normalized": []
},
{
"id": "split_0_train_47358_entity",
"type": "progene_text",
"text": [
"PISTILLATA"
],
"offsets": [
[
61,
71
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],
"normalized": []
},
{
"id": "split_0_train_47359_entity",
"type": "progene_text",
"text": [
"PI"
],
"offsets": [
[
74,
76
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29090
|
split_0_train_29090
|
[
{
"id": "split_0_train_29090_passage",
"type": "progene_text",
"text": [
"AP3 and PI expression are positively regulated by the LEAFY ( LFY ) and UNUSUAL FLORAL ORGANS ( UFO ) genes ."
],
"offsets": [
[
0,
109
]
]
}
] |
[
{
"id": "split_0_train_47360_entity",
"type": "progene_text",
"text": [
"AP3"
],
"offsets": [
[
0,
3
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],
"normalized": []
},
{
"id": "split_0_train_47361_entity",
"type": "progene_text",
"text": [
"PI"
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"offsets": [
[
8,
10
]
],
"normalized": []
},
{
"id": "split_0_train_47362_entity",
"type": "progene_text",
"text": [
"LEAFY"
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"offsets": [
[
54,
59
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],
"normalized": []
},
{
"id": "split_0_train_47363_entity",
"type": "progene_text",
"text": [
"LFY"
],
"offsets": [
[
62,
65
]
],
"normalized": []
},
{
"id": "split_0_train_47364_entity",
"type": "progene_text",
"text": [
"UNUSUAL FLORAL ORGANS"
],
"offsets": [
[
72,
93
]
],
"normalized": []
},
{
"id": "split_0_train_47365_entity",
"type": "progene_text",
"text": [
"UFO"
],
"offsets": [
[
96,
99
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29091
|
split_0_train_29091
|
[
{
"id": "split_0_train_29091_passage",
"type": "progene_text",
"text": [
"UFO encodes an F-box protein , and we have shown previously that UFO genetically interacts with the ASK1 gene encoding a SKP1 homologue ; both the F-box containing protein and SKP1 are subunits of ubiquitin ligases ."
],
"offsets": [
[
0,
216
]
]
}
] |
[
{
"id": "split_0_train_47366_entity",
"type": "progene_text",
"text": [
"UFO"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "split_0_train_47367_entity",
"type": "progene_text",
"text": [
"UFO"
],
"offsets": [
[
65,
68
]
],
"normalized": []
},
{
"id": "split_0_train_47368_entity",
"type": "progene_text",
"text": [
"ASK1"
],
"offsets": [
[
100,
104
]
],
"normalized": []
},
{
"id": "split_0_train_47369_entity",
"type": "progene_text",
"text": [
"SKP1"
],
"offsets": [
[
121,
125
]
],
"normalized": []
},
{
"id": "split_0_train_47370_entity",
"type": "progene_text",
"text": [
"SKP1"
],
"offsets": [
[
176,
180
]
],
"normalized": []
},
{
"id": "split_0_train_47371_entity",
"type": "progene_text",
"text": [
"ubiquitin ligases"
],
"offsets": [
[
197,
214
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29092
|
split_0_train_29092
|
[
{
"id": "split_0_train_29092_passage",
"type": "progene_text",
"text": [
"We show here that the ask1 - 1 mutation can enhance the floral phenotypes of weak lfy and ap3 mutants ; therefore , like UFO , ASK1 also interacts with LFY and AP3 genetically ."
],
"offsets": [
[
0,
177
]
]
}
] |
[
{
"id": "split_0_train_47372_entity",
"type": "progene_text",
"text": [
"ask1"
],
"offsets": [
[
22,
26
]
],
"normalized": []
},
{
"id": "split_0_train_47373_entity",
"type": "progene_text",
"text": [
"lfy"
],
"offsets": [
[
82,
85
]
],
"normalized": []
},
{
"id": "split_0_train_47374_entity",
"type": "progene_text",
"text": [
"ap3"
],
"offsets": [
[
90,
93
]
],
"normalized": []
},
{
"id": "split_0_train_47375_entity",
"type": "progene_text",
"text": [
"UFO"
],
"offsets": [
[
121,
124
]
],
"normalized": []
},
{
"id": "split_0_train_47376_entity",
"type": "progene_text",
"text": [
"ASK1"
],
"offsets": [
[
127,
131
]
],
"normalized": []
},
{
"id": "split_0_train_47377_entity",
"type": "progene_text",
"text": [
"LFY"
],
"offsets": [
[
152,
155
]
],
"normalized": []
},
{
"id": "split_0_train_47378_entity",
"type": "progene_text",
"text": [
"AP3"
],
"offsets": [
[
160,
163
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29093
|
split_0_train_29093
|
[
{
"id": "split_0_train_29093_passage",
"type": "progene_text",
"text": [
"Furthermore , our results from RNA in situ hybridizations indicate that ASK1 regulates early AP3 and PI expression ."
],
"offsets": [
[
0,
116
]
]
}
] |
[
{
"id": "split_0_train_47379_entity",
"type": "progene_text",
"text": [
"ASK1"
],
"offsets": [
[
72,
76
]
],
"normalized": []
},
{
"id": "split_0_train_47380_entity",
"type": "progene_text",
"text": [
"AP3"
],
"offsets": [
[
93,
96
]
],
"normalized": []
},
{
"id": "split_0_train_47381_entity",
"type": "progene_text",
"text": [
"PI"
],
"offsets": [
[
101,
103
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29094
|
split_0_train_29094
|
[
{
"id": "split_0_train_29094_passage",
"type": "progene_text",
"text": [
"These results support the idea that UFO and ASK1 together positively regulate AP3 and PI expression ."
],
"offsets": [
[
0,
101
]
]
}
] |
[
{
"id": "split_0_train_47382_entity",
"type": "progene_text",
"text": [
"UFO"
],
"offsets": [
[
36,
39
]
],
"normalized": []
},
{
"id": "split_0_train_47383_entity",
"type": "progene_text",
"text": [
"ASK1"
],
"offsets": [
[
44,
48
]
],
"normalized": []
},
{
"id": "split_0_train_47384_entity",
"type": "progene_text",
"text": [
"AP3"
],
"offsets": [
[
78,
81
]
],
"normalized": []
},
{
"id": "split_0_train_47385_entity",
"type": "progene_text",
"text": [
"PI"
],
"offsets": [
[
86,
88
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29095
|
split_0_train_29095
|
[
{
"id": "split_0_train_29095_passage",
"type": "progene_text",
"text": [
"We propose that the UFO and ASK1 proteins are components of a ubiquitin ligase that mediates the proteolysis of a repressor of AP3 and PI expression ."
],
"offsets": [
[
0,
150
]
]
}
] |
[
{
"id": "split_0_train_47386_entity",
"type": "progene_text",
"text": [
"UFO"
],
"offsets": [
[
20,
23
]
],
"normalized": []
},
{
"id": "split_0_train_47387_entity",
"type": "progene_text",
"text": [
"ASK1"
],
"offsets": [
[
28,
32
]
],
"normalized": []
},
{
"id": "split_0_train_47388_entity",
"type": "progene_text",
"text": [
"ubiquitin ligase"
],
"offsets": [
[
62,
78
]
],
"normalized": []
},
{
"id": "split_0_train_47389_entity",
"type": "progene_text",
"text": [
"AP3"
],
"offsets": [
[
127,
130
]
],
"normalized": []
},
{
"id": "split_0_train_47390_entity",
"type": "progene_text",
"text": [
"PI"
],
"offsets": [
[
135,
137
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29096
|
split_0_train_29096
|
[
{
"id": "split_0_train_29096_passage",
"type": "progene_text",
"text": [
"Our genetic studies also indicate that ASK1 and UFO play a role in regulating the number of floral organ primordia , and we discuss possible mechanisms for such a regulation ."
],
"offsets": [
[
0,
175
]
]
}
] |
[
{
"id": "split_0_train_47391_entity",
"type": "progene_text",
"text": [
"ASK1"
],
"offsets": [
[
39,
43
]
],
"normalized": []
},
{
"id": "split_0_train_47392_entity",
"type": "progene_text",
"text": [
"UFO"
],
"offsets": [
[
48,
51
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29097
|
split_0_train_29097
|
[
{
"id": "split_0_train_29097_passage",
"type": "progene_text",
"text": [
"Protease inhibitors as potential antiviral agents for the treatment of picornaviral infections ."
],
"offsets": [
[
0,
96
]
]
}
] |
[
{
"id": "split_0_train_47393_entity",
"type": "progene_text",
"text": [
"Protease"
],
"offsets": [
[
0,
8
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29098
|
split_0_train_29098
|
[
{
"id": "split_0_train_29098_passage",
"type": "progene_text",
"text": [
"The picornavirus family contains several human pathogens including human rhinovirus ( HRV ) and hepatitis A virus ( HAV ) ."
],
"offsets": [
[
0,
123
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29099
|
split_0_train_29099
|
[
{
"id": "split_0_train_29099_passage",
"type": "progene_text",
"text": [
"In the case of HRVs , these small single - stranded positive - sense RNA viruses translate their genetic information into a polyprotein precursor which is further processed mainly by two viral proteases designated 2A and 3C ."
],
"offsets": [
[
0,
225
]
]
}
] |
[
{
"id": "split_0_train_47394_entity",
"type": "progene_text",
"text": [
"proteases"
],
"offsets": [
[
193,
202
]
],
"normalized": []
},
{
"id": "split_0_train_47395_entity",
"type": "progene_text",
"text": [
"2A"
],
"offsets": [
[
214,
216
]
],
"normalized": []
},
{
"id": "split_0_train_47396_entity",
"type": "progene_text",
"text": [
"3C"
],
"offsets": [
[
221,
223
]
],
"normalized": []
}
] |
[] |
[] |
[] |
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