id
stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
split_0_train_29100
|
split_0_train_29100
|
[
{
"id": "split_0_train_29100_passage",
"type": "progene_text",
"text": [
"The 2A protease ( 2Apro ) makes the first cleavage between the structural and non - structural proteins , while 3C protease ( 3Cpro ) catalyzes most of the remaining internal cleavages ."
],
"offsets": [
[
0,
186
]
]
}
] |
[
{
"id": "split_0_train_47397_entity",
"type": "progene_text",
"text": [
"2A protease"
],
"offsets": [
[
4,
15
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],
"normalized": []
},
{
"id": "split_0_train_47398_entity",
"type": "progene_text",
"text": [
"2Apro"
],
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[
18,
23
]
],
"normalized": []
},
{
"id": "split_0_train_47399_entity",
"type": "progene_text",
"text": [
"structural and non - structural proteins"
],
"offsets": [
[
63,
103
]
],
"normalized": []
},
{
"id": "split_0_train_47400_entity",
"type": "progene_text",
"text": [
"3C protease"
],
"offsets": [
[
112,
123
]
],
"normalized": []
},
{
"id": "split_0_train_47401_entity",
"type": "progene_text",
"text": [
"3Cpro"
],
"offsets": [
[
126,
131
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29101
|
split_0_train_29101
|
[
{
"id": "split_0_train_29101_passage",
"type": "progene_text",
"text": [
"It has been shown that both 2Apro and 3Cpro are cysteine proteases but their overall protein folding is more like trypsin - type serine proteases ."
],
"offsets": [
[
0,
147
]
]
}
] |
[
{
"id": "split_0_train_47402_entity",
"type": "progene_text",
"text": [
"2Apro"
],
"offsets": [
[
28,
33
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],
"normalized": []
},
{
"id": "split_0_train_47403_entity",
"type": "progene_text",
"text": [
"3Cpro"
],
"offsets": [
[
38,
43
]
],
"normalized": []
},
{
"id": "split_0_train_47404_entity",
"type": "progene_text",
"text": [
"cysteine proteases"
],
"offsets": [
[
48,
66
]
],
"normalized": []
},
{
"id": "split_0_train_47405_entity",
"type": "progene_text",
"text": [
"trypsin - type serine proteases"
],
"offsets": [
[
114,
145
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29102
|
split_0_train_29102
|
[
{
"id": "split_0_train_29102_passage",
"type": "progene_text",
"text": [
"Due to their unique protein structure and essential roles in viral replication , 2Apro and 3Cpro have been viewed as excellent targets for antiviral intervention ."
],
"offsets": [
[
0,
163
]
]
}
] |
[
{
"id": "split_0_train_47406_entity",
"type": "progene_text",
"text": [
"2Apro"
],
"offsets": [
[
81,
86
]
],
"normalized": []
},
{
"id": "split_0_train_47407_entity",
"type": "progene_text",
"text": [
"3Cpro"
],
"offsets": [
[
91,
96
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29103
|
split_0_train_29103
|
[
{
"id": "split_0_train_29103_passage",
"type": "progene_text",
"text": [
"In recent years , considerable efforts have been made in the development of antiviral compounds targeting these proteases ."
],
"offsets": [
[
0,
123
]
]
}
] |
[
{
"id": "split_0_train_47408_entity",
"type": "progene_text",
"text": [
"proteases"
],
"offsets": [
[
112,
121
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29104
|
split_0_train_29104
|
[
{
"id": "split_0_train_29104_passage",
"type": "progene_text",
"text": [
"This article summarizes the recent approaches in the design of novel 2A and 3C protease inhibitors as potential antiviral agents for the treatment of picornaviral infections ."
],
"offsets": [
[
0,
175
]
]
}
] |
[
{
"id": "split_0_train_47409_entity",
"type": "progene_text",
"text": [
"2A and 3C protease"
],
"offsets": [
[
69,
87
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29105
|
split_0_train_29105
|
[
{
"id": "split_0_train_29105_passage",
"type": "progene_text",
"text": [
"Molecular cloning of a gene encoding matrix metalloproteinase - like protein from Gnathostoma spinigerum ."
],
"offsets": [
[
0,
106
]
]
}
] |
[
{
"id": "split_0_train_47410_entity",
"type": "progene_text",
"text": [
"matrix metalloproteinase - like protein"
],
"offsets": [
[
37,
76
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29106
|
split_0_train_29106
|
[
{
"id": "split_0_train_29106_passage",
"type": "progene_text",
"text": [
"The advanced third - stage larvae ( aL3 ) of Gnathostoma spinigerum contain a 24 kDa glycoprotein with diagnostic potential ."
],
"offsets": [
[
0,
125
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29107
|
split_0_train_29107
|
[
{
"id": "split_0_train_29107_passage",
"type": "progene_text",
"text": [
"Immunoscreening with the monoclonal antibody to the 24 - kDa protein ( mAb GN6 / 24 ) has identified a cDNA clone with an insert of 932 base pairs ( bp ) ."
],
"offsets": [
[
0,
155
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29108
|
split_0_train_29108
|
[
{
"id": "split_0_train_29108_passage",
"type": "progene_text",
"text": [
"The insert contains a full - length gene of 732 bp encoding a protein that is 33 - 39 % similar to matrix metalloproteinases ( MMPs ) of Caenorhabditis elegans and several lower and higher vertebrates ."
],
"offsets": [
[
0,
202
]
]
}
] |
[
{
"id": "split_0_train_47411_entity",
"type": "progene_text",
"text": [
"matrix metalloproteinases"
],
"offsets": [
[
99,
124
]
],
"normalized": []
},
{
"id": "split_0_train_47412_entity",
"type": "progene_text",
"text": [
"MMPs"
],
"offsets": [
[
127,
131
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29109
|
split_0_train_29109
|
[
{
"id": "split_0_train_29109_passage",
"type": "progene_text",
"text": [
"The MMP - like protein of G. spinigerum possesses the catalytic domain , but lacks the propeptide and hemopexin - like domains found in other MMPs ."
],
"offsets": [
[
0,
148
]
]
}
] |
[
{
"id": "split_0_train_47413_entity",
"type": "progene_text",
"text": [
"MMP - like protein"
],
"offsets": [
[
4,
22
]
],
"normalized": []
},
{
"id": "split_0_train_47414_entity",
"type": "progene_text",
"text": [
"hemopexin"
],
"offsets": [
[
102,
111
]
],
"normalized": []
},
{
"id": "split_0_train_47415_entity",
"type": "progene_text",
"text": [
"MMPs"
],
"offsets": [
[
142,
146
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29110
|
split_0_train_29110
|
[
{
"id": "split_0_train_29110_passage",
"type": "progene_text",
"text": [
"A signal peptide of 23 amino acids at its amino terminus indicates that it is a secretory protein , which is confirmed by Western blot analysis showing the presence of the 24 kDa protein in the excretory - secretory products of aL3 ."
],
"offsets": [
[
0,
233
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29111
|
split_0_train_29111
|
[
{
"id": "split_0_train_29111_passage",
"type": "progene_text",
"text": [
"Phosphotyrosyl peptides block Stat3 - mediated DNA binding activity , gene regulation , and cell transformation ."
],
"offsets": [
[
0,
113
]
]
}
] |
[
{
"id": "split_0_train_47416_entity",
"type": "progene_text",
"text": [
"Stat3"
],
"offsets": [
[
30,
35
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29112
|
split_0_train_29112
|
[
{
"id": "split_0_train_29112_passage",
"type": "progene_text",
"text": [
"Signal transducers and activators of transcription ( STATs ) comprise a family of cytoplasmic signaling proteins that participates in normal cellular responses to cytokines and growth factors ."
],
"offsets": [
[
0,
193
]
]
}
] |
[
{
"id": "split_0_train_47417_entity",
"type": "progene_text",
"text": [
"Signal transducers and activators of transcription"
],
"offsets": [
[
0,
50
]
],
"normalized": []
},
{
"id": "split_0_train_47418_entity",
"type": "progene_text",
"text": [
"STATs"
],
"offsets": [
[
53,
58
]
],
"normalized": []
},
{
"id": "split_0_train_47419_entity",
"type": "progene_text",
"text": [
"cytokines"
],
"offsets": [
[
163,
172
]
],
"normalized": []
},
{
"id": "split_0_train_47420_entity",
"type": "progene_text",
"text": [
"growth factors"
],
"offsets": [
[
177,
191
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29113
|
split_0_train_29113
|
[
{
"id": "split_0_train_29113_passage",
"type": "progene_text",
"text": [
"Frequently , however , constitutive activation of certain STAT family members , particularly Stat3 , has accompanied a wide variety of human malignancies ."
],
"offsets": [
[
0,
155
]
]
}
] |
[
{
"id": "split_0_train_47421_entity",
"type": "progene_text",
"text": [
"STAT family"
],
"offsets": [
[
58,
69
]
],
"normalized": []
},
{
"id": "split_0_train_47422_entity",
"type": "progene_text",
"text": [
"Stat3"
],
"offsets": [
[
93,
98
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29114
|
split_0_train_29114
|
[
{
"id": "split_0_train_29114_passage",
"type": "progene_text",
"text": [
"To identify small molecule inhibitors of Stat3 , we investigated the ability of the Stat3 SH2 domain - binding peptide , PY*LKTK ( where Y* represents phosphotyrosine ) , to disrupt Stat3 activity in vitro ."
],
"offsets": [
[
0,
207
]
]
}
] |
[
{
"id": "split_0_train_47423_entity",
"type": "progene_text",
"text": [
"Stat3"
],
"offsets": [
[
41,
46
]
],
"normalized": []
},
{
"id": "split_0_train_47424_entity",
"type": "progene_text",
"text": [
"Stat3"
],
"offsets": [
[
84,
89
]
],
"normalized": []
},
{
"id": "split_0_train_47425_entity",
"type": "progene_text",
"text": [
"Stat3"
],
"offsets": [
[
182,
187
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29115
|
split_0_train_29115
|
[
{
"id": "split_0_train_29115_passage",
"type": "progene_text",
"text": [
"The presence of PY*LKTK , but not PYLKTK or PFLKTK , in nuclear extracts results in significant reduction in the levels of DNA binding activities of Stat3 , to a lesser extent of Stat1 , and with no effect on that of Stat5 ."
],
"offsets": [
[
0,
224
]
]
}
] |
[
{
"id": "split_0_train_47426_entity",
"type": "progene_text",
"text": [
"Stat3"
],
"offsets": [
[
149,
154
]
],
"normalized": []
},
{
"id": "split_0_train_47427_entity",
"type": "progene_text",
"text": [
"Stat1"
],
"offsets": [
[
179,
184
]
],
"normalized": []
},
{
"id": "split_0_train_47428_entity",
"type": "progene_text",
"text": [
"Stat5"
],
"offsets": [
[
217,
222
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29116
|
split_0_train_29116
|
[
{
"id": "split_0_train_29116_passage",
"type": "progene_text",
"text": [
"Analyses of alanine scanning mutagenesis and deletion derivatives of PY*LKTK reveal that the Leu residue at the Y+1 position and a substituent at the Y-1 position ( but not necessarily Pro ) are essential for the disruption of active Stat3 , thereby mapping the minimum active sequence to the tripeptide , XY*L ."
],
"offsets": [
[
0,
312
]
]
}
] |
[
{
"id": "split_0_train_47429_entity",
"type": "progene_text",
"text": [
"Stat3"
],
"offsets": [
[
234,
239
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29117
|
split_0_train_29117
|
[
{
"id": "split_0_train_29117_passage",
"type": "progene_text",
"text": [
"Studies involving bead - coupled PY*LKTK peptide demonstrate that this phosphopeptide directly complexes with Stat3 monomers in vitro , suggesting that PY*LKTK disrupts Stat3 : Stat3 dimers ."
],
"offsets": [
[
0,
191
]
]
}
] |
[
{
"id": "split_0_train_47430_entity",
"type": "progene_text",
"text": [
"Stat3"
],
"offsets": [
[
110,
115
]
],
"normalized": []
},
{
"id": "split_0_train_47431_entity",
"type": "progene_text",
"text": [
"Stat3"
],
"offsets": [
[
169,
174
]
],
"normalized": []
},
{
"id": "split_0_train_47432_entity",
"type": "progene_text",
"text": [
"Stat3"
],
"offsets": [
[
177,
182
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29118
|
split_0_train_29118
|
[
{
"id": "split_0_train_29118_passage",
"type": "progene_text",
"text": [
"As evidence for the functional importance of peptide - directed inhibition of Stat3 , PY*LKTK-mts ( mts , membrane translocating sequence ) selectively inhibits constitutive and ligand - induced Stat3 activation in vivo ."
],
"offsets": [
[
0,
221
]
]
}
] |
[
{
"id": "split_0_train_47433_entity",
"type": "progene_text",
"text": [
"Stat3"
],
"offsets": [
[
78,
83
]
],
"normalized": []
},
{
"id": "split_0_train_47434_entity",
"type": "progene_text",
"text": [
"Stat3"
],
"offsets": [
[
195,
200
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29119
|
split_0_train_29119
|
[
{
"id": "split_0_train_29119_passage",
"type": "progene_text",
"text": [
"Furthermore , PY*LKTK - mts suppresses transformation by the Src oncoprotein , which has been shown previously to require constitutive Stat3 activation ."
],
"offsets": [
[
0,
153
]
]
}
] |
[
{
"id": "split_0_train_47435_entity",
"type": "progene_text",
"text": [
"Src"
],
"offsets": [
[
61,
64
]
],
"normalized": []
},
{
"id": "split_0_train_47436_entity",
"type": "progene_text",
"text": [
"Stat3"
],
"offsets": [
[
135,
140
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29120
|
split_0_train_29120
|
[
{
"id": "split_0_train_29120_passage",
"type": "progene_text",
"text": [
"Altogether , we have identified a minimal peptide that inhibits Stat3 signaling and provides the conceptual basis for use of this peptide as a lead for novel peptidomimetic drug design ."
],
"offsets": [
[
0,
186
]
]
}
] |
[
{
"id": "split_0_train_47437_entity",
"type": "progene_text",
"text": [
"Stat3"
],
"offsets": [
[
64,
69
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29121
|
split_0_train_29121
|
[
{
"id": "split_0_train_29121_passage",
"type": "progene_text",
"text": [
"Clinical impact of combination of scatter , attenuation correction , and depth - dependent resolution recovery for ( 201 ) Tl studies ."
],
"offsets": [
[
0,
135
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29122
|
split_0_train_29122
|
[
{
"id": "split_0_train_29122_passage",
"type": "progene_text",
"text": [
"A lack of specificity for myocardial perfusion imaging has been widely reported , mostly related to false - positive defects on the inferior wall ."
],
"offsets": [
[
0,
147
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29123
|
split_0_train_29123
|
[
{
"id": "split_0_train_29123_passage",
"type": "progene_text",
"text": [
"The application of depth - dependent resolution recovery ( RR ) , attenuation correction ( AC ) using external source devices , and scatter correction has been proposed to resolve this pitfall ."
],
"offsets": [
[
0,
194
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29124
|
split_0_train_29124
|
[
{
"id": "split_0_train_29124_passage",
"type": "progene_text",
"text": [
"METHODS :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29125
|
split_0_train_29125
|
[
{
"id": "split_0_train_29125_passage",
"type": "progene_text",
"text": [
"We studied the clinical benefit of depth - dependent RR , nonuniform AC using a scanning line source , and scatter correction ( photon energy recovery [ PER]) compared with filtered backprojection alone ."
],
"offsets": [
[
0,
204
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29126
|
split_0_train_29126
|
[
{
"id": "split_0_train_29126_passage",
"type": "progene_text",
"text": [
"Eighty - two patients were included : 40 healthy volunteers with a low likelihood of coronary artery disease ( control group ) and 42 patients with proven right or circumflex coronary artery disease but without involvement of the left anterior descending artery ."
],
"offsets": [
[
0,
263
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29127
|
split_0_train_29127
|
[
{
"id": "split_0_train_29127_passage",
"type": "progene_text",
"text": [
"Among these 82 patients , the images of 33 were also processed with PER ."
],
"offsets": [
[
0,
73
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29128
|
split_0_train_29128
|
[
{
"id": "split_0_train_29128_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29129
|
split_0_train_29129
|
[
{
"id": "split_0_train_29129_passage",
"type": "progene_text",
"text": [
"RR did not alter the performance of filtered backprojection alone ."
],
"offsets": [
[
0,
67
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29130
|
split_0_train_29130
|
[
{
"id": "split_0_train_29130_passage",
"type": "progene_text",
"text": [
"AC + RR greatly improved specificity and the rate of normal ( 201 ) Tl SPECT findings in the control population ( from 56 % to 95 % and from 53 % to 100 % , respectively ) but significantly decreased sensitivity ( from 92 % to 54 % ) ."
],
"offsets": [
[
0,
235
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29131
|
split_0_train_29131
|
[
{
"id": "split_0_train_29131_passage",
"type": "progene_text",
"text": [
"AC + RR generated a false anteroapical defect in 21 % of patients and reverse redistribution of the apex in 23 % ."
],
"offsets": [
[
0,
114
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29132
|
split_0_train_29132
|
[
{
"id": "split_0_train_29132_passage",
"type": "progene_text",
"text": [
"AC + RR significantly decreased the extent of the stress defect ( from 4.09 to 3.21 segments , P < 0.003 ) and increased the perfusion score of the stress defect ( from 0.78 +/- 0.72 to 1.47 +/- 1.11 , P < 0.00061 ) ."
],
"offsets": [
[
0,
217
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29133
|
split_0_train_29133
|
[
{
"id": "split_0_train_29133_passage",
"type": "progene_text",
"text": [
"Moreover , AC + RR generated overcorrection on the inferior wall , leading to false estimation of viability for 11 of 15 patients with an old inferior myocardial scar without evidence of residual viability ."
],
"offsets": [
[
0,
207
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29134
|
split_0_train_29134
|
[
{
"id": "split_0_train_29134_passage",
"type": "progene_text",
"text": [
"PER decreased overcorrection on the inferior wall , but without improving sensitivity ."
],
"offsets": [
[
0,
87
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29135
|
split_0_train_29135
|
[
{
"id": "split_0_train_29135_passage",
"type": "progene_text",
"text": [
"PER did not significantly reduce the number of anteroapical false - positives or the number of apical reverse distribution cases ."
],
"offsets": [
[
0,
130
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29136
|
split_0_train_29136
|
[
{
"id": "split_0_train_29136_passage",
"type": "progene_text",
"text": [
"CONCLUSION :"
],
"offsets": [
[
0,
12
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29137
|
split_0_train_29137
|
[
{
"id": "split_0_train_29137_passage",
"type": "progene_text",
"text": [
"AC + RR improved the specificity and normalcy rate of ( 201 ) Tl SPECT myocardial perfusion imaging but generated overcorrection on the inferior wall , leading to low sensitivity and to false evaluation of myocardial viability in 73 % of the patients with inferior infarction ."
],
"offsets": [
[
0,
277
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29138
|
split_0_train_29138
|
[
{
"id": "split_0_train_29138_passage",
"type": "progene_text",
"text": [
"AC + RR also generated anteroapical artifacts ."
],
"offsets": [
[
0,
47
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29139
|
split_0_train_29139
|
[
{
"id": "split_0_train_29139_passage",
"type": "progene_text",
"text": [
"The addition of scatter correction did not significantly reduce these drawbacks ."
],
"offsets": [
[
0,
81
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29140
|
split_0_train_29140
|
[
{
"id": "split_0_train_29140_passage",
"type": "progene_text",
"text": [
"Hermansky - Pudlak syndrome type 3 in Ashkenazi Jews and other non - Puerto Rican patients with hypopigmentation and platelet storage - pool deficiency ."
],
"offsets": [
[
0,
153
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29141
|
split_0_train_29141
|
[
{
"id": "split_0_train_29141_passage",
"type": "progene_text",
"text": [
"Hermansky - Pudlak syndrome ( HPS ) , consisting of oculocutaneous albinism and a bleeding diathesis due to the absence of platelet dense granules , displays extensive locus heterogeneity ."
],
"offsets": [
[
0,
189
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29142
|
split_0_train_29142
|
[
{
"id": "split_0_train_29142_passage",
"type": "progene_text",
"text": [
"HPS1 mutations cause HPS-1 disease , and ADTB3A mutations cause HPS-2 disease , which is known to involve abnormal intracellular vesicle formation ."
],
"offsets": [
[
0,
148
]
]
}
] |
[
{
"id": "split_0_train_47438_entity",
"type": "progene_text",
"text": [
"HPS1"
],
"offsets": [
[
0,
4
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29143
|
split_0_train_29143
|
[
{
"id": "split_0_train_29143_passage",
"type": "progene_text",
"text": [
"A third HPS - causing gene , HPS3 , was recently identified on the basis of homozygosity mapping of a genetic isolate of HPS in central Puerto Rico ."
],
"offsets": [
[
0,
149
]
]
}
] |
[
{
"id": "split_0_train_47439_entity",
"type": "progene_text",
"text": [
"HPS3"
],
"offsets": [
[
29,
33
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29144
|
split_0_train_29144
|
[
{
"id": "split_0_train_29144_passage",
"type": "progene_text",
"text": [
"We now describe the clinical and molecular characteristics of eight patients with HPS-3 who are of non - Puerto Rican heritage ."
],
"offsets": [
[
0,
128
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29145
|
split_0_train_29145
|
[
{
"id": "split_0_train_29145_passage",
"type": "progene_text",
"text": [
"Five are Ashkenazi Jews ; three of these are homozygous for a 1303 + 1G --> A splice - site mutation that causes skipping of exon 5 , deleting an RsaI restriction site and decreasing the amounts of mRNA found on northern blotting ."
],
"offsets": [
[
0,
231
]
]
}
] |
[
{
"id": "split_0_train_47440_entity",
"type": "progene_text",
"text": [
"RsaI"
],
"offsets": [
[
146,
150
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29146
|
split_0_train_29146
|
[
{
"id": "split_0_train_29146_passage",
"type": "progene_text",
"text": [
"The other two are heterozygous for the 1303 +1G --> A mutation and for either an 1831 +2T --> G or a 2621 -2A --> G splicing mutation ."
],
"offsets": [
[
0,
135
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29147
|
split_0_train_29147
|
[
{
"id": "split_0_train_29147_passage",
"type": "progene_text",
"text": [
"Of 235 anonymous Ashkenazi Jewish DNA samples , one was heterozygous for the 1303 + 1G --> A mutation ."
],
"offsets": [
[
0,
103
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29148
|
split_0_train_29148
|
[
{
"id": "split_0_train_29148_passage",
"type": "progene_text",
"text": [
"One seven - year - old boy of German / Swiss extraction was compound heterozygous for a 2729 + 1G --> C mutation , causing skipping of exon 14 , and resulting in a C1329T missense ( R396W ) , with decreased mRNA production ."
],
"offsets": [
[
0,
224
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29149
|
split_0_train_29149
|
[
{
"id": "split_0_train_29149_passage",
"type": "progene_text",
"text": [
"A 15 - year - old Irish / English boy was heterozygous for an 89 - bp insertion between exons 16 and 17 resulting from abnormal splicing ; his fibroblast HPS3 mRNA is normal in amount but is increased in size ."
],
"offsets": [
[
0,
210
]
]
}
] |
[
{
"id": "split_0_train_47441_entity",
"type": "progene_text",
"text": [
"HPS3"
],
"offsets": [
[
154,
158
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29150
|
split_0_train_29150
|
[
{
"id": "split_0_train_29150_passage",
"type": "progene_text",
"text": [
"A 12 - year - old girl of Puerto Rican and Italian background has the 3,904-bp founder deletion from central Puerto Rico on one allele ."
],
"offsets": [
[
0,
136
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29151
|
split_0_train_29151
|
[
{
"id": "split_0_train_29151_passage",
"type": "progene_text",
"text": [
"All eight patients have mild symptoms of HPS ; two Jewish patients had received the diagnosis of ocular , rather than oculocutaneous , albinism ."
],
"offsets": [
[
0,
145
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29152
|
split_0_train_29152
|
[
{
"id": "split_0_train_29152_passage",
"type": "progene_text",
"text": [
"These findings expand the molecular diagnosis of HPS , provide a screening method for a mutation common among Jews , and suggest that other patients with mild hypopigmentation and decreased vision should be examined for HPS ."
],
"offsets": [
[
0,
225
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29153
|
split_0_train_29153
|
[
{
"id": "split_0_train_29153_passage",
"type": "progene_text",
"text": [
"Genetic factors in the development of gastric precancerous lesions -- a role of Helicobacter pylori ?"
],
"offsets": [
[
0,
101
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29154
|
split_0_train_29154
|
[
{
"id": "split_0_train_29154_passage",
"type": "progene_text",
"text": [
"Helicobacter pylori is believed to predispose to gastric cancer by inducing gastric precancerous alterations ."
],
"offsets": [
[
0,
110
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29155
|
split_0_train_29155
|
[
{
"id": "split_0_train_29155_passage",
"type": "progene_text",
"text": [
"There is a well known predisposition to gastric cancer and the risk of developing it is greater in relatives of patients with familial cases of this malignancy ."
],
"offsets": [
[
0,
161
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29156
|
split_0_train_29156
|
[
{
"id": "split_0_train_29156_passage",
"type": "progene_text",
"text": [
"The aim of this study was to determine the prevalence of gastric precancerous lesions ( atrophy and intestinal metaplasia ) and their association with Hp infection in first - degree relatives in patients with noncardia gastric cancer ."
],
"offsets": [
[
0,
235
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29157
|
split_0_train_29157
|
[
{
"id": "split_0_train_29157_passage",
"type": "progene_text",
"text": [
"METHODS :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29158
|
split_0_train_29158
|
[
{
"id": "split_0_train_29158_passage",
"type": "progene_text",
"text": [
"Hp status and gastric histology assessed by upper gastrointestinal endoscopy , biopsies from the antral and body region , the rapid urease test and staining for Hp , inflammation , activity , atrophy and intestinal metaplasia ( prevalence and grading ) were studied in 108 first - degree relatives of patients with noncardia gastric cancer and compared with 73 controls with mild non - ulcer dyspepsia who had no cancer relatives and were examined in the same way ."
],
"offsets": [
[
0,
465
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29159
|
split_0_train_29159
|
[
{
"id": "split_0_train_29159_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29160
|
split_0_train_29160
|
[
{
"id": "split_0_train_29160_passage",
"type": "progene_text",
"text": [
"subjects with and without cancer relatives had a similar prevalence of Hp infection ( 49 vs. 47 % ) ."
],
"offsets": [
[
0,
101
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29161
|
split_0_train_29161
|
[
{
"id": "split_0_train_29161_passage",
"type": "progene_text",
"text": [
"Endoscopy revealed a few asymptomatic duodenal ulcers and small hiatus hernias in Hp positive subjects of both groups ."
],
"offsets": [
[
0,
119
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29162
|
split_0_train_29162
|
[
{
"id": "split_0_train_29162_passage",
"type": "progene_text",
"text": [
"Hp positive relatives of gastric cancer had a markedly higher prevalence of atrophy than those with Hp negativity without cancer relatives ( 29 vs. 9 % ) and those with Hp negativity and cancer relatives ( 29 vs. 3 % . Prevalence of intestinal metaplasia was also higher in those with Hp positivity and cancer relatives than in those without cancer relatives ( 15 vs. 5 % and was not present in Hp negative subjects with cancer relatives. Inflammation and activity showed similar scores in subjects with and without cancer relatives with higher scores in both Hp positive groups ."
],
"offsets": [
[
0,
580
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29163
|
split_0_train_29163
|
[
{
"id": "split_0_train_29163_passage",
"type": "progene_text",
"text": [
"The prevalence of precancerous lesions in the relatives of gastric cancer was nearly always confined to those with Hp positivity ."
],
"offsets": [
[
0,
130
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29164
|
split_0_train_29164
|
[
{
"id": "split_0_train_29164_passage",
"type": "progene_text",
"text": [
"One year after eradication the prevalence of atrophy in cancer relatives decreased from 29 to 14 % ; prevalence of intestinal metaplasia remained without substantial changes ."
],
"offsets": [
[
0,
175
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29165
|
split_0_train_29165
|
[
{
"id": "split_0_train_29165_passage",
"type": "progene_text",
"text": [
"Scores for inflammation and activity were also lower after eradication ."
],
"offsets": [
[
0,
72
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29166
|
split_0_train_29166
|
[
{
"id": "split_0_train_29166_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29167
|
split_0_train_29167
|
[
{
"id": "split_0_train_29167_passage",
"type": "progene_text",
"text": [
"First - degree relatives of patients with gastric cancer have an increased prevalence of gastric precancerous abnormalities which are strongly confined to those with Hp infection ."
],
"offsets": [
[
0,
180
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29168
|
split_0_train_29168
|
[
{
"id": "split_0_train_29168_passage",
"type": "progene_text",
"text": [
"Eradication of Hp in these subjects with cancer relatives reduces the prevalence of precancerous lesions ( atrophy ) and grades of inflammation and activity ."
],
"offsets": [
[
0,
158
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29169
|
split_0_train_29169
|
[
{
"id": "split_0_train_29169_passage",
"type": "progene_text",
"text": [
"In view of these results , eradication of Hp should be offered to such subjects ."
],
"offsets": [
[
0,
81
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29170
|
split_0_train_29170
|
[
{
"id": "split_0_train_29170_passage",
"type": "progene_text",
"text": [
"Molecular control of acid phosphatase secretion into the rhizosphere of proteoid roots from phosphorus - stressed white lupin ."
],
"offsets": [
[
0,
127
]
]
}
] |
[
{
"id": "split_0_train_47442_entity",
"type": "progene_text",
"text": [
"acid phosphatase"
],
"offsets": [
[
21,
37
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29171
|
split_0_train_29171
|
[
{
"id": "split_0_train_29171_passage",
"type": "progene_text",
"text": [
"White lupin ( Lupinus albus ) grown under P deficiency displays a suite of highly coordinated adaptive responses ."
],
"offsets": [
[
0,
114
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29172
|
split_0_train_29172
|
[
{
"id": "split_0_train_29172_passage",
"type": "progene_text",
"text": [
"Included among these is secretion of copious amounts of acid phosphatase ( APase ) ."
],
"offsets": [
[
0,
84
]
]
}
] |
[
{
"id": "split_0_train_47443_entity",
"type": "progene_text",
"text": [
"acid phosphatase"
],
"offsets": [
[
56,
72
]
],
"normalized": []
},
{
"id": "split_0_train_47444_entity",
"type": "progene_text",
"text": [
"APase"
],
"offsets": [
[
75,
80
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29173
|
split_0_train_29173
|
[
{
"id": "split_0_train_29173_passage",
"type": "progene_text",
"text": [
"Although numerous reports document that plants secrete APases in response to P deficiency , little is known of the biochemical and molecular events involved in this process ."
],
"offsets": [
[
0,
174
]
]
}
] |
[
{
"id": "split_0_train_47445_entity",
"type": "progene_text",
"text": [
"APases"
],
"offsets": [
[
55,
61
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29174
|
split_0_train_29174
|
[
{
"id": "split_0_train_29174_passage",
"type": "progene_text",
"text": [
"Here we characterize the secreted APase protein , cDNA , and gene from white lupin ."
],
"offsets": [
[
0,
84
]
]
}
] |
[
{
"id": "split_0_train_47446_entity",
"type": "progene_text",
"text": [
"APase"
],
"offsets": [
[
34,
39
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29175
|
split_0_train_29175
|
[
{
"id": "split_0_train_29175_passage",
"type": "progene_text",
"text": [
"The secreted APase enzyme is a glycoprotein with broad substrate specificity ."
],
"offsets": [
[
0,
78
]
]
}
] |
[
{
"id": "split_0_train_47447_entity",
"type": "progene_text",
"text": [
"APase"
],
"offsets": [
[
13,
18
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29176
|
split_0_train_29176
|
[
{
"id": "split_0_train_29176_passage",
"type": "progene_text",
"text": [
"It is synthesized as a preprotein with a deduced M(r) of 52,000 containing a 31 - amino acid presequence ."
],
"offsets": [
[
0,
106
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29177
|
split_0_train_29177
|
[
{
"id": "split_0_train_29177_passage",
"type": "progene_text",
"text": [
"Analysis of the presequence predicts that the protein is targeted to outside the cell ."
],
"offsets": [
[
0,
87
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29178
|
split_0_train_29178
|
[
{
"id": "split_0_train_29178_passage",
"type": "progene_text",
"text": [
"The processed protein has a predicted M(r) of 49,000 but migrates as a protein with M(r) of 70,000 on sodium dodecyl sulfate gels ."
],
"offsets": [
[
0,
131
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29179
|
split_0_train_29179
|
[
{
"id": "split_0_train_29179_passage",
"type": "progene_text",
"text": [
"This is likely due to glycosylation ."
],
"offsets": [
[
0,
37
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29180
|
split_0_train_29180
|
[
{
"id": "split_0_train_29180_passage",
"type": "progene_text",
"text": [
"Enhanced expression is fairly specific to proteoid roots of P-stressed plants and involves enhanced synthesis of both enzyme protein and mRNA ."
],
"offsets": [
[
0,
143
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29181
|
split_0_train_29181
|
[
{
"id": "split_0_train_29181_passage",
"type": "progene_text",
"text": [
"Secreted APase appears to be encoded by a single gene containing seven exons interrupted by six introns ."
],
"offsets": [
[
0,
105
]
]
}
] |
[
{
"id": "split_0_train_47448_entity",
"type": "progene_text",
"text": [
"APase"
],
"offsets": [
[
9,
14
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29182
|
split_0_train_29182
|
[
{
"id": "split_0_train_29182_passage",
"type": "progene_text",
"text": [
"The 5' - upstream putative promoter of the white lupin - secreted APase contains a 50 - base pair region having 72 % identity to an Arabidopsis APase promoter that is responsive to P deficiency ."
],
"offsets": [
[
0,
195
]
]
}
] |
[
{
"id": "split_0_train_47449_entity",
"type": "progene_text",
"text": [
"APase"
],
"offsets": [
[
66,
71
]
],
"normalized": []
},
{
"id": "split_0_train_47450_entity",
"type": "progene_text",
"text": [
"APase"
],
"offsets": [
[
144,
149
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29183
|
split_0_train_29183
|
[
{
"id": "split_0_train_29183_passage",
"type": "progene_text",
"text": [
"The white lupin - secreted APase promoter and targeting sequence may be useful tools for genetically engineering important proteins from plant roots ."
],
"offsets": [
[
0,
150
]
]
}
] |
[
{
"id": "split_0_train_47451_entity",
"type": "progene_text",
"text": [
"APase"
],
"offsets": [
[
27,
32
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29184
|
split_0_train_29184
|
[
{
"id": "split_0_train_29184_passage",
"type": "progene_text",
"text": [
"Further identification and characterization of novel intermediate and mature cleavage products released from the ORF 1b region of the avian coronavirus infectious bronchitis virus 1a / 1b polyprotein ."
],
"offsets": [
[
0,
201
]
]
}
] |
[
{
"id": "split_0_train_47452_entity",
"type": "progene_text",
"text": [
"1a / 1b polyprotein"
],
"offsets": [
[
180,
199
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29185
|
split_0_train_29185
|
[
{
"id": "split_0_train_29185_passage",
"type": "progene_text",
"text": [
"The coronavirus 3C - like proteinase is one of the viral proteinases responsible for processing of the 1a and 1a / 1b polyproteins to multiple mature products ."
],
"offsets": [
[
0,
160
]
]
}
] |
[
{
"id": "split_0_train_47453_entity",
"type": "progene_text",
"text": [
"3C - like proteinase"
],
"offsets": [
[
16,
36
]
],
"normalized": []
},
{
"id": "split_0_train_47454_entity",
"type": "progene_text",
"text": [
"proteinases"
],
"offsets": [
[
57,
68
]
],
"normalized": []
},
{
"id": "split_0_train_47455_entity",
"type": "progene_text",
"text": [
"1a and 1a / 1b polyproteins"
],
"offsets": [
[
103,
130
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29186
|
split_0_train_29186
|
[
{
"id": "split_0_train_29186_passage",
"type": "progene_text",
"text": [
"In cells infected with avian coronavirus infectious bronchitis virus ( IBV ) , three proteins of 100 , 39 , and 35 kDa , respectively , were previously identified as mature cleavage products released from the 1b region of the 1a / 1b polyprotein by the 3C - like proteinase ."
],
"offsets": [
[
0,
275
]
]
}
] |
[
{
"id": "split_0_train_47456_entity",
"type": "progene_text",
"text": [
"1a / 1b polyprotein"
],
"offsets": [
[
226,
245
]
],
"normalized": []
},
{
"id": "split_0_train_47457_entity",
"type": "progene_text",
"text": [
"3C - like proteinase"
],
"offsets": [
[
253,
273
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29187
|
split_0_train_29187
|
[
{
"id": "split_0_train_29187_passage",
"type": "progene_text",
"text": [
"In this report , we show the identification of two more cleavage products of 68 and 58 kDa released from the same region of the polyprotein ."
],
"offsets": [
[
0,
141
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29188
|
split_0_train_29188
|
[
{
"id": "split_0_train_29188_passage",
"type": "progene_text",
"text": [
"In addition , two stable intermediate cleavage products with molecular masses of 160 and 132 kDa , respectively , were identified in IBV - infected cells ."
],
"offsets": [
[
0,
155
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29189
|
split_0_train_29189
|
[
{
"id": "split_0_train_29189_passage",
"type": "progene_text",
"text": [
"The 160 - kDa protein was shown to be an intermediate cleavage product covering the 100 - and 68 - kDa proteins , and the 132 - kDa protein to be an intermediate cleavage product covering the 58 - , 39 - , and 35 - kDa proteins ."
],
"offsets": [
[
0,
229
]
]
}
] |
[
{
"id": "split_0_train_47458_entity",
"type": "progene_text",
"text": [
"100 - and 68 - kDa proteins"
],
"offsets": [
[
84,
111
]
],
"normalized": []
},
{
"id": "split_0_train_47459_entity",
"type": "progene_text",
"text": [
"58 - , 39 - , and 35 - kDa proteins"
],
"offsets": [
[
192,
227
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29190
|
split_0_train_29190
|
[
{
"id": "split_0_train_29190_passage",
"type": "progene_text",
"text": [
"Immunofluorescent staining of IBV - infected cells and cells expressing individual cleavage products showed that the 100 - , 68 - , and 58 - kDa proteins were associated with the membranes of the endoplasmic reticulum , and the 39 - and 35 - kDa proteins displayed diffuse distribution patterns ."
],
"offsets": [
[
0,
296
]
]
}
] |
[
{
"id": "split_0_train_47460_entity",
"type": "progene_text",
"text": [
"100 - , 68 - , and 58 - kDa proteins"
],
"offsets": [
[
117,
153
]
],
"normalized": []
},
{
"id": "split_0_train_47461_entity",
"type": "progene_text",
"text": [
"39 - and 35 - kDa proteins"
],
"offsets": [
[
228,
254
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29191
|
split_0_train_29191
|
[
{
"id": "split_0_train_29191_passage",
"type": "progene_text",
"text": [
"Comparison of German language versions of the QWB-SA and SF-36 evaluating outcomes for patients with prostate disease ."
],
"offsets": [
[
0,
119
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29192
|
split_0_train_29192
|
[
{
"id": "split_0_train_29192_passage",
"type": "progene_text",
"text": [
"BACKGROUND :"
],
"offsets": [
[
0,
12
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29193
|
split_0_train_29193
|
[
{
"id": "split_0_train_29193_passage",
"type": "progene_text",
"text": [
"The quality of well - being scale ( QWB ) and the Medical Outcome Study 36 - item short form ( SF-36 ) are alternative methods for measuring general health outcomes ."
],
"offsets": [
[
0,
166
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29194
|
split_0_train_29194
|
[
{
"id": "split_0_train_29194_passage",
"type": "progene_text",
"text": [
"Few studies compare these approaches against one another and no studies have compared German language versions ."
],
"offsets": [
[
0,
112
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29195
|
split_0_train_29195
|
[
{
"id": "split_0_train_29195_passage",
"type": "progene_text",
"text": [
"METHOD :"
],
"offsets": [
[
0,
8
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29196
|
split_0_train_29196
|
[
{
"id": "split_0_train_29196_passage",
"type": "progene_text",
"text": [
"A German language version of the self - administered quality of well - being scale ( QWB-SA ) was developed using forward and back translation methods ."
],
"offsets": [
[
0,
152
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29197
|
split_0_train_29197
|
[
{
"id": "split_0_train_29197_passage",
"type": "progene_text",
"text": [
"The German QWB-SA and a German language version of the SF-36 were administered to clinical population groups with current diagnoses of prostate cancer , benign hyperplasia of the prostate , colon cancer , and rectal cancer ."
],
"offsets": [
[
0,
224
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29198
|
split_0_train_29198
|
[
{
"id": "split_0_train_29198_passage",
"type": "progene_text",
"text": [
"Data were obtained from four German clinics ."
],
"offsets": [
[
0,
45
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29199
|
split_0_train_29199
|
[
{
"id": "split_0_train_29199_passage",
"type": "progene_text",
"text": [
"In addition to the quality of life measures , data on cancer stage and disease state were obtained ."
],
"offsets": [
[
0,
100
]
]
}
] |
[] |
[] |
[] |
[] |
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