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stringlengths 15
19
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19
| passages
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list | events
list | coreferences
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|---|---|---|---|---|---|---|
split_0_train_29300
|
split_0_train_29300
|
[
{
"id": "split_0_train_29300_passage",
"type": "progene_text",
"text": [
"Deafferentation of the eye muscles did not affect baseline ocular motor control , either acutely or over a 5 - week period of study ."
],
"offsets": [
[
0,
133
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29301
|
split_0_train_29301
|
[
{
"id": "split_0_train_29301_passage",
"type": "progene_text",
"text": [
"Furthermore , visually mediated adaptation of the eye movement subtypes was also unaffected by deafferentation ."
],
"offsets": [
[
0,
112
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29302
|
split_0_train_29302
|
[
{
"id": "split_0_train_29302_passage",
"type": "progene_text",
"text": [
"These results suggest that ocular proprioception in primates is not used in the immediate , on - line control of eye movements and does not interact with visual cues in the adaptive modification of ocular motor function ."
],
"offsets": [
[
0,
221
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29303
|
split_0_train_29303
|
[
{
"id": "split_0_train_29303_passage",
"type": "progene_text",
"text": [
"We conclude that the efferent command ( efference copy ) provides sufficient information about eye kinematics to the brain for accurate eye movement control in normal monkeys , and that this information is modified by visual feedback independently of proprioception ."
],
"offsets": [
[
0,
267
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29304
|
split_0_train_29304
|
[
{
"id": "split_0_train_29304_passage",
"type": "progene_text",
"text": [
"We hypothesize that proprioception may be used to calibrate the efference copy during development and in response to perturbations by signaling potential mismatches between eye movement information derived from the efferent command and the actual motion of the eye transduced by the proprioceptive organs ."
],
"offsets": [
[
0,
306
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29305
|
split_0_train_29305
|
[
{
"id": "split_0_train_29305_passage",
"type": "progene_text",
"text": [
"Skill transfer from virtual reality to a real laparoscopic task ."
],
"offsets": [
[
0,
65
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29306
|
split_0_train_29306
|
[
{
"id": "split_0_train_29306_passage",
"type": "progene_text",
"text": [
"BACKGROUND :"
],
"offsets": [
[
0,
12
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29307
|
split_0_train_29307
|
[
{
"id": "split_0_train_29307_passage",
"type": "progene_text",
"text": [
"To validate the usefulness of virtual reality surgical simulators , we investigated the transfer of skills achieved by their use to real tasks ."
],
"offsets": [
[
0,
144
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29308
|
split_0_train_29308
|
[
{
"id": "split_0_train_29308_passage",
"type": "progene_text",
"text": [
"METHODS :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29309
|
split_0_train_29309
|
[
{
"id": "split_0_train_29309_passage",
"type": "progene_text",
"text": [
"Thirty medical students underwent a pretest using a real laparoscopic trainer ."
],
"offsets": [
[
0,
79
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29310
|
split_0_train_29310
|
[
{
"id": "split_0_train_29310_passage",
"type": "progene_text",
"text": [
"They were then randomized to the following three groups : group I received no training ; group II received training using the Minimal Invasive Surgical Trainer in Virtual Reality ( MIST-VR ) ; and group III received training using conventional training exercises ."
],
"offsets": [
[
0,
264
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29311
|
split_0_train_29311
|
[
{
"id": "split_0_train_29311_passage",
"type": "progene_text",
"text": [
"Each group then underwent a posttest ."
],
"offsets": [
[
0,
38
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29312
|
split_0_train_29312
|
[
{
"id": "split_0_train_29312_passage",
"type": "progene_text",
"text": [
"Using the Imperial College Surgical Assessment Device ( ICSAD ) , scores were generated for time taken , distance traveled , number of movements made , and speed of instrument movement ."
],
"offsets": [
[
0,
186
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29313
|
split_0_train_29313
|
[
{
"id": "split_0_train_29313_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29314
|
split_0_train_29314
|
[
{
"id": "split_0_train_29314_passage",
"type": "progene_text",
"text": [
"Significant changes between the MIST - VR group ( group II ) and the conventionally trained group ( group III ) , were observed in the speed of movement of the left hand and the numbers of movements taken by each hand , when compared to the untrained group ( group I ) ."
],
"offsets": [
[
0,
270
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29315
|
split_0_train_29315
|
[
{
"id": "split_0_train_29315_passage",
"type": "progene_text",
"text": [
"CONCLUSION :"
],
"offsets": [
[
0,
12
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29316
|
split_0_train_29316
|
[
{
"id": "split_0_train_29316_passage",
"type": "progene_text",
"text": [
"The training of novices using MIST-VR yields quantifiable changes in skill that are transferable to a simple real task and are similar to the results achieved with conventional training ."
],
"offsets": [
[
0,
187
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29317
|
split_0_train_29317
|
[
{
"id": "split_0_train_29317_passage",
"type": "progene_text",
"text": [
"Development and field validation of an avidin - biotin enzyme - linked immunosorbent assay kit for bovine brucellosis ."
],
"offsets": [
[
0,
119
]
]
}
] |
[
{
"id": "split_0_train_47490_entity",
"type": "progene_text",
"text": [
"avidin"
],
"offsets": [
[
39,
45
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29318
|
split_0_train_29318
|
[
{
"id": "split_0_train_29318_passage",
"type": "progene_text",
"text": [
"The avidin - biotin enzyme - linked immunosorbent assay ( A-B ELISA ) , for use in surveillance for bovine brucellosis in India was developed and calibrated using the indirect brucellosis ELISA kit of the International Atomic Energy Agency ( IAEA ) as a reference ."
],
"offsets": [
[
0,
265
]
]
}
] |
[
{
"id": "split_0_train_47491_entity",
"type": "progene_text",
"text": [
"avidin"
],
"offsets": [
[
4,
10
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29319
|
split_0_train_29319
|
[
{
"id": "split_0_train_29319_passage",
"type": "progene_text",
"text": [
"The reagents used in the A-B ELISA were as follows : the smooth lipopolysaccharide of Brucella abortus strain 99 ( antigen ) ; biotinylated anti - bovine immunoglobulin G ( detection antibody ) ; avidin - horseradish peroxidase ( conjugate ) ; and O-phenylenediamine dihydrochloride ( chromogen ) ."
],
"offsets": [
[
0,
298
]
]
}
] |
[
{
"id": "split_0_train_47492_entity",
"type": "progene_text",
"text": [
"immunoglobulin G"
],
"offsets": [
[
154,
170
]
],
"normalized": []
},
{
"id": "split_0_train_47493_entity",
"type": "progene_text",
"text": [
"avidin"
],
"offsets": [
[
196,
202
]
],
"normalized": []
},
{
"id": "split_0_train_47494_entity",
"type": "progene_text",
"text": [
"peroxidase"
],
"offsets": [
[
217,
227
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29320
|
split_0_train_29320
|
[
{
"id": "split_0_train_29320_passage",
"type": "progene_text",
"text": [
"The test results were interpreted using the IAEA software EDI version 2.1.1 , which was modified for use in the A-B ELISA ."
],
"offsets": [
[
0,
123
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29321
|
split_0_train_29321
|
[
{
"id": "split_0_train_29321_passage",
"type": "progene_text",
"text": [
"The cut - off percentage positivity value was established using 500 brucellosis - positive and 500 brucellosis - negative serum samples , confirmed with reference to the sample data using the indirect ELISA kit ."
],
"offsets": [
[
0,
212
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29322
|
split_0_train_29322
|
[
{
"id": "split_0_train_29322_passage",
"type": "progene_text",
"text": [
"The overall specificity of A-B ELISA was 98.8 % and overall sensitivity was 98.2 % ."
],
"offsets": [
[
0,
84
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29323
|
split_0_train_29323
|
[
{
"id": "split_0_train_29323_passage",
"type": "progene_text",
"text": [
"Field validation of the A-B ELISA kit was undertaken in six laboratories in India ."
],
"offsets": [
[
0,
83
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29324
|
split_0_train_29324
|
[
{
"id": "split_0_train_29324_passage",
"type": "progene_text",
"text": [
"Screening of 7,040 cattle and 678 buffalo serum samples from 12 states revealed serological evidence of brucellosis in 8.7 % of cattle and 10.2 % of buffalo ."
],
"offsets": [
[
0,
158
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29325
|
split_0_train_29325
|
[
{
"id": "split_0_train_29325_passage",
"type": "progene_text",
"text": [
"This kit proved to be robust and performed with a similar sensitivity and specificity to the indirect ELISA ."
],
"offsets": [
[
0,
109
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29326
|
split_0_train_29326
|
[
{
"id": "split_0_train_29326_passage",
"type": "progene_text",
"text": [
"The kit can be supplied at a lower cost than current commercial ELISA kits ."
],
"offsets": [
[
0,
76
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29327
|
split_0_train_29327
|
[
{
"id": "split_0_train_29327_passage",
"type": "progene_text",
"text": [
"Autosomal - dominant hypophosphatemic rickets ( ADHR ) mutations stabilize FGF-23 ."
],
"offsets": [
[
0,
83
]
]
}
] |
[
{
"id": "split_0_train_47495_entity",
"type": "progene_text",
"text": [
"FGF-23"
],
"offsets": [
[
75,
81
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29328
|
split_0_train_29328
|
[
{
"id": "split_0_train_29328_passage",
"type": "progene_text",
"text": [
"BACKGROUND :"
],
"offsets": [
[
0,
12
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29329
|
split_0_train_29329
|
[
{
"id": "split_0_train_29329_passage",
"type": "progene_text",
"text": [
"The gene for the renal phosphate wasting disorder autosomal - dominant hypophosphatemic rickets ( ADHR ) is FGF23 , which encodes a secreted protein related to the fibroblast growth factors ( FGFs ) ."
],
"offsets": [
[
0,
200
]
]
}
] |
[
{
"id": "split_0_train_47496_entity",
"type": "progene_text",
"text": [
"FGF23"
],
"offsets": [
[
108,
113
]
],
"normalized": []
},
{
"id": "split_0_train_47497_entity",
"type": "progene_text",
"text": [
"fibroblast growth factors"
],
"offsets": [
[
164,
189
]
],
"normalized": []
},
{
"id": "split_0_train_47498_entity",
"type": "progene_text",
"text": [
"FGFs"
],
"offsets": [
[
192,
196
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29330
|
split_0_train_29330
|
[
{
"id": "split_0_train_29330_passage",
"type": "progene_text",
"text": [
"We previously detected missense mutations R176Q , R179W , and R179Q in FGF23 from ADHR kindreds ."
],
"offsets": [
[
0,
97
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29331
|
split_0_train_29331
|
[
{
"id": "split_0_train_29331_passage",
"type": "progene_text",
"text": [
"The mutations replace R residues within a subtilisin - like proprotein convertase ( SPC ) cleavage site 176RHTR-179 ( RXXR motif ) ."
],
"offsets": [
[
0,
132
]
]
}
] |
[
{
"id": "split_0_train_47499_entity",
"type": "progene_text",
"text": [
"subtilisin - like proprotein convertase"
],
"offsets": [
[
42,
81
]
],
"normalized": []
},
{
"id": "split_0_train_47500_entity",
"type": "progene_text",
"text": [
"SPC"
],
"offsets": [
[
84,
87
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29332
|
split_0_train_29332
|
[
{
"id": "split_0_train_29332_passage",
"type": "progene_text",
"text": [
"The goal of these studies was to determine if the ADHR mutations lead to protease resistance of FGF-23 ."
],
"offsets": [
[
0,
104
]
]
}
] |
[
{
"id": "split_0_train_47501_entity",
"type": "progene_text",
"text": [
"protease"
],
"offsets": [
[
73,
81
]
],
"normalized": []
},
{
"id": "split_0_train_47502_entity",
"type": "progene_text",
"text": [
"FGF-23"
],
"offsets": [
[
96,
102
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29333
|
split_0_train_29333
|
[
{
"id": "split_0_train_29333_passage",
"type": "progene_text",
"text": [
"METHODS :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29334
|
split_0_train_29334
|
[
{
"id": "split_0_train_29334_passage",
"type": "progene_text",
"text": [
"The ADHR mutations were introduced into human FGF-23 cDNA clones with or without an N - terminal FLAG tag by site - directed mutagenesis and were transiently transfected into HEK293 cells ."
],
"offsets": [
[
0,
189
]
]
}
] |
[
{
"id": "split_0_train_47503_entity",
"type": "progene_text",
"text": [
"FGF-23"
],
"offsets": [
[
46,
52
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29335
|
split_0_train_29335
|
[
{
"id": "split_0_train_29335_passage",
"type": "progene_text",
"text": [
"Protein expression was determined by Western analyses ."
],
"offsets": [
[
0,
55
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29336
|
split_0_train_29336
|
[
{
"id": "split_0_train_29336_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29337
|
split_0_train_29337
|
[
{
"id": "split_0_train_29337_passage",
"type": "progene_text",
"text": [
"Antibodies directed toward the C - terminal portion of FGF-23 revealed that the native FGF-23 protein resolved as 32 kD and 12 kD species in HEK293 conditioned media ; however , the three mutated proteins were detected only as the 32 kD band ."
],
"offsets": [
[
0,
243
]
]
}
] |
[
{
"id": "split_0_train_47504_entity",
"type": "progene_text",
"text": [
"FGF-23"
],
"offsets": [
[
55,
61
]
],
"normalized": []
},
{
"id": "split_0_train_47505_entity",
"type": "progene_text",
"text": [
"FGF-23"
],
"offsets": [
[
87,
93
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29338
|
split_0_train_29338
|
[
{
"id": "split_0_train_29338_passage",
"type": "progene_text",
"text": [
"An N - terminal FLAG - tagged native FGF-23 resolved as two bands of 36 kD and 26 kD when detected with a FLAG antibody , whereas the R176Q mutant resolved primarily as the 36 kD protein species ."
],
"offsets": [
[
0,
196
]
]
}
] |
[
{
"id": "split_0_train_47506_entity",
"type": "progene_text",
"text": [
"FGF-23"
],
"offsets": [
[
37,
43
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29339
|
split_0_train_29339
|
[
{
"id": "split_0_train_29339_passage",
"type": "progene_text",
"text": [
"Cleavage of FGF-23 was not enhanced by extracellular incubation of FGF-23 with HEK293 cells ."
],
"offsets": [
[
0,
93
]
]
}
] |
[
{
"id": "split_0_train_47507_entity",
"type": "progene_text",
"text": [
"FGF-23"
],
"offsets": [
[
12,
18
]
],
"normalized": []
},
{
"id": "split_0_train_47508_entity",
"type": "progene_text",
"text": [
"FGF-23"
],
"offsets": [
[
67,
73
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29340
|
split_0_train_29340
|
[
{
"id": "split_0_train_29340_passage",
"type": "progene_text",
"text": [
"Native and mutant FGF-23s bound heparin ."
],
"offsets": [
[
0,
41
]
]
}
] |
[
{
"id": "split_0_train_47509_entity",
"type": "progene_text",
"text": [
"FGF-23s"
],
"offsets": [
[
18,
25
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29341
|
split_0_train_29341
|
[
{
"id": "split_0_train_29341_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29342
|
split_0_train_29342
|
[
{
"id": "split_0_train_29342_passage",
"type": "progene_text",
"text": [
"FGF-23 proteins containing the ADHR mutations are secreted , and produce polypeptides less sensitive to protease cleavage than wild - type FGF-23 ."
],
"offsets": [
[
0,
147
]
]
}
] |
[
{
"id": "split_0_train_47510_entity",
"type": "progene_text",
"text": [
"FGF-23"
],
"offsets": [
[
0,
6
]
],
"normalized": []
},
{
"id": "split_0_train_47511_entity",
"type": "progene_text",
"text": [
"protease"
],
"offsets": [
[
104,
112
]
],
"normalized": []
},
{
"id": "split_0_train_47512_entity",
"type": "progene_text",
"text": [
"FGF-23"
],
"offsets": [
[
139,
145
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split_0_train_29345
|
split_0_train_29345
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split_0_train_29346
|
split_0_train_29346
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split_0_train_29347
|
split_0_train_29347
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[] |
[] |
[] |
split_0_train_29348
|
split_0_train_29348
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"The interaction was enhanced by conditions that favor the oligomerization of vinculin ."
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[] |
[] |
split_0_train_29349
|
split_0_train_29349
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[] |
[] |
split_0_train_29350
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split_0_train_29350
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"text": [
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[] |
[] |
[] |
split_0_train_29351
|
split_0_train_29351
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[
{
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[] |
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split_0_train_29352
|
split_0_train_29352
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"We suggest a possible mechanism whereby phospholipid - regulated conformational changes in vinculin may lead to exposure of a docking site for protein kinase Calpha and subsequent phosphorylation of vinculin and/or vinculin interaction partners , thereby affecting the formation of cell adhesion complexes ."
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[] |
[] |
[] |
split_0_train_29353
|
split_0_train_29353
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"text": [
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] |
[] |
[] |
[] |
split_0_train_29354
|
split_0_train_29354
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{
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"text": [
"Recent reports have shown that tumor necrosis factor - alpha ( TNF-alpha ) can augment the effects of radiation against certain tumor types ."
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0,
141
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{
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63,
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[] |
[] |
[] |
split_0_train_29355
|
split_0_train_29355
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[
{
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"type": "progene_text",
"text": [
"However , the high concentrations of intravenous infusion of TNF-alpha needed to cause tumor regression can induce many systemic side effects ."
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"text": [
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61,
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[] |
[] |
[] |
split_0_train_29356
|
split_0_train_29356
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[
{
"id": "split_0_train_29356_passage",
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"text": [
"The aims of this study were to determine if TNF-alpha encapsulated in sterically stabilized ( Stealth , ALZA Corporation , Mountain View , CA ) , PEGylated liposomes ( SL ) augments the antitumor effects of radiation and to compare its efficacy and possible toxicity with free TNF-alpha in the LS174T human colon tumor xenograft model ."
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0,
336
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{
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277,
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[] |
[] |
[] |
split_0_train_29357
|
split_0_train_29357
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[
{
"id": "split_0_train_29357_passage",
"type": "progene_text",
"text": [
"Nude mice were injected subcutaneously ( s.c. ) with LS174T cells and treated intravenously ( i.v. ) with Stealth - liposomal TNF-alpha ( SL-TNF-alpha ) with and without radiation or TNF-alpha with or without radiation when tumor size was approximately 200 mm(3) ."
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183,
192
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] |
[] |
[] |
[] |
split_0_train_29358
|
split_0_train_29358
|
[
{
"id": "split_0_train_29358_passage",
"type": "progene_text",
"text": [
"In phase 1 , a significant decrease ( p = 0.047 ) in tumor growth was observed with radiation at day 21 but not with SL - TNF - alpha or free TNF-alpha alone ."
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[
0,
159
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}
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[
{
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122,
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142,
151
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] |
[] |
[] |
[] |
split_0_train_29359
|
split_0_train_29359
|
[
{
"id": "split_0_train_29359_passage",
"type": "progene_text",
"text": [
"By the end of phase 1 ( day 27 ) with continued treatments , the SL - TNF - alpha plus radiation group had significantly smaller tumors ( p = 0.044 ) than those in the free TNF-alpha plus radiation group ."
],
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[
0,
205
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]
}
] |
[
{
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"text": [
"TNF-alpha"
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173,
182
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}
] |
[] |
[] |
[] |
split_0_train_29360
|
split_0_train_29360
|
[
{
"id": "split_0_train_29360_passage",
"type": "progene_text",
"text": [
"In phase 2 , where a similar tumor growth reduction pattern was observed , the addition of TNF-alpha to radiation , either as free protein or within SL , increased lymphocyte activation and natural killer ( NK ) cell numbers in both blood and spleen ."
],
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[
0,
251
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]
}
] |
[
{
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"text": [
"TNF-alpha"
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[
91,
100
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}
] |
[] |
[] |
[] |
split_0_train_29361
|
split_0_train_29361
|
[
{
"id": "split_0_train_29361_passage",
"type": "progene_text",
"text": [
"The effect was generally more pronounced with SL - TNF-alpha ."
],
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[
0,
62
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]
}
] |
[
{
"id": "split_0_train_47546_entity",
"type": "progene_text",
"text": [
"TNF-alpha"
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51,
60
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}
] |
[] |
[] |
[] |
split_0_train_29362
|
split_0_train_29362
|
[
{
"id": "split_0_train_29362_passage",
"type": "progene_text",
"text": [
"Systemic toxicity , based on hematologic analyses and body weight , was absent or minimal ."
],
"offsets": [
[
0,
91
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29363
|
split_0_train_29363
|
[
{
"id": "split_0_train_29363_passage",
"type": "progene_text",
"text": [
"Collectively , the data show that pretreatment with SL - TNF-alpha can enhance more effectively , and possibly more safely , the effects of radiation against human colon tumor xenografts than can free TNF-alpha and that the increased antitumor action may involve upregulation of lymphocytes ."
],
"offsets": [
[
0,
292
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]
}
] |
[
{
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57,
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"type": "progene_text",
"text": [
"TNF-alpha"
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201,
210
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}
] |
[] |
[] |
[] |
split_0_train_29364
|
split_0_train_29364
|
[
{
"id": "split_0_train_29364_passage",
"type": "progene_text",
"text": [
"Alvimopan* ( ADL 8 - 2698 ) is a novel peripheral opioid antagonist ."
],
"offsets": [
[
0,
69
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29365
|
split_0_train_29365
|
[
{
"id": "split_0_train_29365_passage",
"type": "progene_text",
"text": [
"Alvimopan ( ADL 8 - 2698 ; Adolor Corporation , Exton , PA , USA ) is a novel , peripherally restricted opioid antagonist ."
],
"offsets": [
[
0,
123
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29366
|
split_0_train_29366
|
[
{
"id": "split_0_train_29366_passage",
"type": "progene_text",
"text": [
"After oral administration , it has activity specific to the gastrointestinal ( GI ) tract ."
],
"offsets": [
[
0,
91
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29367
|
split_0_train_29367
|
[
{
"id": "split_0_train_29367_passage",
"type": "progene_text",
"text": [
"ADL 8 - 2698 has low systemic absorption and a high affinity for mu - opioid receptors ."
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[
0,
88
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]
}
] |
[
{
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"type": "progene_text",
"text": [
"mu - opioid receptors"
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[
65,
86
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}
] |
[] |
[] |
[] |
split_0_train_29368
|
split_0_train_29368
|
[
{
"id": "split_0_train_29368_passage",
"type": "progene_text",
"text": [
"In healthy subjects , ADL 8 - 2698 antagonized loperamide - induced changes in GI transit and prevented morphine - induced delays in oral - cecal transit time without antagonizing centrally mediated opioid effects , such as analgesia or pupillary constriction ."
],
"offsets": [
[
0,
261
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29369
|
split_0_train_29369
|
[
{
"id": "split_0_train_29369_passage",
"type": "progene_text",
"text": [
"In the treatment of opioid naive patients who underwent surgery and received opioids for acute pain , oral ADL 8 - 2698 ( 6.0 mg ) improved the management of postoperative ileus ( POI ) by shortening the time to achieve normal bowel function and , ultimately , hospital stay ."
],
"offsets": [
[
0,
276
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29370
|
split_0_train_29370
|
[
{
"id": "split_0_train_29370_passage",
"type": "progene_text",
"text": [
"Postoperative nausea and vomiting and the overall incidence of all GI side effects were reduced in patients treated with ADL 8 - 2698 for POI ."
],
"offsets": [
[
0,
143
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29371
|
split_0_train_29371
|
[
{
"id": "split_0_train_29371_passage",
"type": "progene_text",
"text": [
"Analgesia was not compromised , because there were no changes in median opioid consumption or Visual Analog Scale ( VAS ) pain scores in patients treated with ADL 8 - 2698 versus patients treated with placebo ."
],
"offsets": [
[
0,
210
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29372
|
split_0_train_29372
|
[
{
"id": "split_0_train_29372_passage",
"type": "progene_text",
"text": [
"No drug - related side effects were observed in acute pain postsurgical patients in the initial POI study ."
],
"offsets": [
[
0,
107
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29373
|
split_0_train_29373
|
[
{
"id": "split_0_train_29373_passage",
"type": "progene_text",
"text": [
"In patients treated with opioids for chronic pain or opioid addiction , lower doses of oral ADL 8 - 2698 ( 0.5 to 3.0 mg ) reversed opioid bowel dysfunction ( OBD ) and normalized GI activity ."
],
"offsets": [
[
0,
193
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29374
|
split_0_train_29374
|
[
{
"id": "split_0_train_29374_passage",
"type": "progene_text",
"text": [
"These effects were evident without compromising opioid analgesia or inducing central nervous system symptoms of withdrawal ."
],
"offsets": [
[
0,
124
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29375
|
split_0_train_29375
|
[
{
"id": "split_0_train_29375_passage",
"type": "progene_text",
"text": [
"Some chronic opioid patients receiving apparently supramaximal doses of ADL 8 - 2698 ( > or = 3.0 mg ) reported localized GI side effects , possibly indicative of a localized GI withdrawal response ."
],
"offsets": [
[
0,
199
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29376
|
split_0_train_29376
|
[
{
"id": "split_0_train_29376_passage",
"type": "progene_text",
"text": [
"The most common side effects of ADL 8 - 2698 in chronic pain patients with OBD were abdominal pain , flatulence , and diarrhea ."
],
"offsets": [
[
0,
128
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29377
|
split_0_train_29377
|
[
{
"id": "split_0_train_29377_passage",
"type": "progene_text",
"text": [
"These effects were not observed in most OBD patients receiving lower doses of ADL 8 - 2698 ."
],
"offsets": [
[
0,
92
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29378
|
split_0_train_29378
|
[
{
"id": "split_0_train_29378_passage",
"type": "progene_text",
"text": [
"Overall , ADL 8 - 2698 was well tolerated in clinical trials ."
],
"offsets": [
[
0,
62
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29379
|
split_0_train_29379
|
[
{
"id": "split_0_train_29379_passage",
"type": "progene_text",
"text": [
"Further studies to evaluate the efficacy and safety of ADL 8 - 2698 in clinical practice are in progress ."
],
"offsets": [
[
0,
106
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29380
|
split_0_train_29380
|
[
{
"id": "split_0_train_29380_passage",
"type": "progene_text",
"text": [
"[ Cochleography and cochlear view as the way of assessment of successful surgical inner ear implantation ] 115 cochlear implantation were performed in ENT Department Karol Marcinkowski University of Medical Sciences in PoznaÃ?â?? in 1994 - 2001 ."
],
"offsets": [
[
0,
246
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29381
|
split_0_train_29381
|
[
{
"id": "split_0_train_29381_passage",
"type": "progene_text",
"text": [
"Nucleus Mini System 22 and Nucleus 24 of Cochlear Ltd were used in these operations ."
],
"offsets": [
[
0,
85
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29382
|
split_0_train_29382
|
[
{
"id": "split_0_train_29382_passage",
"type": "progene_text",
"text": [
"Two approaches were performed : middle fossa approach in one case and traditional one ."
],
"offsets": [
[
0,
87
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29383
|
split_0_train_29383
|
[
{
"id": "split_0_train_29383_passage",
"type": "progene_text",
"text": [
"The aim of this study was evaluation of cochleogram and cochlear view as the ways of assessment of successful inner ear implantation ."
],
"offsets": [
[
0,
134
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29384
|
split_0_train_29384
|
[
{
"id": "split_0_train_29384_passage",
"type": "progene_text",
"text": [
"One of X-ray projection were performed in implanted patients 24 hours after implantation ."
],
"offsets": [
[
0,
90
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29385
|
split_0_train_29385
|
[
{
"id": "split_0_train_29385_passage",
"type": "progene_text",
"text": [
"In cochleograms the degree of electrodes rotation in cochlea was calculated ."
],
"offsets": [
[
0,
77
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29386
|
split_0_train_29386
|
[
{
"id": "split_0_train_29386_passage",
"type": "progene_text",
"text": [
"The number of inserted electrodes in cochlea was calculated in cochler view projection ."
],
"offsets": [
[
0,
88
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29387
|
split_0_train_29387
|
[
{
"id": "split_0_train_29387_passage",
"type": "progene_text",
"text": [
"Described X-ray projection were performed in 70 patients ."
],
"offsets": [
[
0,
58
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29388
|
split_0_train_29388
|
[
{
"id": "split_0_train_29388_passage",
"type": "progene_text",
"text": [
"On X-ray projection ( cochleograms ) rotation degree of electrodes in majority were equal or higher than 250 grades ( according to literature it is sufficient for successful speech rehabilitation ) ."
],
"offsets": [
[
0,
199
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29389
|
split_0_train_29389
|
[
{
"id": "split_0_train_29389_passage",
"type": "progene_text",
"text": [
"X - ray projection -- cochlear view confirmed full insertion of electrode ."
],
"offsets": [
[
0,
75
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29390
|
split_0_train_29390
|
[
{
"id": "split_0_train_29390_passage",
"type": "progene_text",
"text": [
"[ CT evaluation of the primary extracranial neoplastic diseases eroding the central skull base ]"
],
"offsets": [
[
0,
96
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29391
|
split_0_train_29391
|
[
{
"id": "split_0_train_29391_passage",
"type": "progene_text",
"text": [
"OBJECTIVE :"
],
"offsets": [
[
0,
11
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29392
|
split_0_train_29392
|
[
{
"id": "split_0_train_29392_passage",
"type": "progene_text",
"text": [
"To evaluate the central skull base erosion caused by primary extracranial mass lesions with CT ."
],
"offsets": [
[
0,
96
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29393
|
split_0_train_29393
|
[
{
"id": "split_0_train_29393_passage",
"type": "progene_text",
"text": [
"METHODS :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29394
|
split_0_train_29394
|
[
{
"id": "split_0_train_29394_passage",
"type": "progene_text",
"text": [
"Forty-nine patients ( 33 males and 16 females ; mean , 40.2 years ) suffered from the primary extracranial neoplastic diseases with middle skull base involvement were divided into two groups : group I ( 10 cases ) , primary osseous lesions of the central skull base and group II ( 39 cases ) , primary maxillofacial neoplasms ."
],
"offsets": [
[
0,
327
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29395
|
split_0_train_29395
|
[
{
"id": "split_0_train_29395_passage",
"type": "progene_text",
"text": [
"All lesions were confirmed histopathologically by surgery and biopsy ."
],
"offsets": [
[
0,
70
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29396
|
split_0_train_29396
|
[
{
"id": "split_0_train_29396_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29397
|
split_0_train_29397
|
[
{
"id": "split_0_train_29397_passage",
"type": "progene_text",
"text": [
"Four invasion patterns of the central skull base were identified on CT : I. resorption of the cortical bone ( 30 cases ) , including outer cortical margin destruction in 16 cases ( group II lesions ) and both inner and outer laminae resorption in 14 cases ( 4 group I lesions and 10 groups II lesions ) ."
],
"offsets": [
[
0,
304
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29398
|
split_0_train_29398
|
[
{
"id": "split_0_train_29398_passage",
"type": "progene_text",
"text": [
"II. ossification and thickening of the skull base ( 4 group I cases , all were fibrous dysplasia ) III ."
],
"offsets": [
[
0,
104
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29399
|
split_0_train_29399
|
[
{
"id": "split_0_train_29399_passage",
"type": "progene_text",
"text": [
"erosive enlargement of the ovale and rotundam foramina ( 9 group II cases ) ."
],
"offsets": [
[
0,
77
]
]
}
] |
[] |
[] |
[] |
[] |
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