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split_0_train_29400
|
split_0_train_29400
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"IV. combined sclerosis and resorption of the skull base ( 6 cases , 2 group I lesions and 4 group II lesions ) ."
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0,
112
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[] |
[] |
[] |
[] |
split_0_train_29401
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split_0_train_29401
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"Involvement of the intracranial structures embraced the cavernous sinus ( n = 12 ; group II lesions ) , temporal lobe ( n = 11 ; 5 group I lesions and 6 group II lesions ) , and pituitary ( n = 2 , group II lesions ) ."
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218
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[] |
[] |
[] |
[] |
split_0_train_29402
|
split_0_train_29402
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"CT demonstrated the following central skull base structures were eroded : greater wing of sphenoid bone ( n = 34 ) , sphenoid body ( n = 22 ) , sphenoid process ( n = 23 ) , petrous bone ( n = 15 ) , and articular fossa of the temporal bone ( n = 8 ) ."
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[] |
[] |
[] |
[] |
split_0_train_29403
|
split_0_train_29403
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"text": [
"CONCLUSION :"
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12
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}
] |
[] |
[] |
[] |
[] |
split_0_train_29404
|
split_0_train_29404
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"text": [
"Osseous lesions originating from the central skull base have various CT manifestations ."
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[] |
[] |
[] |
[] |
split_0_train_29405
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split_0_train_29405
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"The cortical resorption of the central skull base may be regarded as a main pattern of bone erosion caused by primary maxillofacial neoplasms , and most of them have lesions involve the greater wing of sphenoid bone through the deeper maxillofacial spaces , such as the infratemporal , pterygopalatine and parapharyngeal spaces ."
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[] |
[] |
[] |
[] |
split_0_train_29406
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split_0_train_29406
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"The ankyrin - B C - terminal domain determines activity of ankyrin-B / G chimeras in rescue of abnormal inositol 1,4,5-trisphosphate and ryanodine receptor distribution in ankyrin-B ( -/- ) neonatal cardiomyocytes ."
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215
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4,
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"ankyrin-B"
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172,
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[] |
[] |
split_0_train_29407
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split_0_train_29407
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"Ankyrins are a closely related family of membrane adaptor proteins that are believed to participate in targeting diverse membrane proteins to specialized domains in the plasma membrane and endoplasmic reticulum ."
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0,
212
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"adaptor proteins"
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50,
66
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[] |
[] |
[] |
split_0_train_29408
|
split_0_train_29408
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{
"id": "split_0_train_29408_passage",
"type": "progene_text",
"text": [
"This study addresses the question of how individual ankyrin isoforms achieve functional specificity when co - expressed in the same cell ."
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0,
138
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"ankyrin"
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52,
59
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[] |
[] |
[] |
split_0_train_29409
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split_0_train_29409
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"Cardiomyocytes from ankyrin-B ( -/- ) mice display mis - localization of inositol 1,4,5-trisphosphate receptors and ryanodine receptors along with reduced contraction rates that can be rescued by expression of green fluorescent protein ( GFP ) - ankyrin-B but not GFP - ankyrin-G ."
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0,
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20,
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73,
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246,
255
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"GFP"
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264,
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"text": [
"ankyrin-G"
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[
270,
279
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}
] |
[] |
[] |
[] |
split_0_train_29410
|
split_0_train_29410
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[
{
"id": "split_0_train_29410_passage",
"type": "progene_text",
"text": [
"We developed chimeric GFP expression constructs containing all combinations of the three major domains of ankyrin - B and ankyrin-G to determine which domain(s) of ankyrin-B are required for ankyrin-B - specific functions ."
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"offsets": [
[
0,
223
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"GFP"
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22,
25
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"ankyrin - B"
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106,
117
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{
"id": "split_0_train_47567_entity",
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"ankyrin-G"
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122,
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"ankyrin-B"
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164,
173
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"type": "progene_text",
"text": [
"ankyrin-B"
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"offsets": [
[
191,
200
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29411
|
split_0_train_29411
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[
{
"id": "split_0_train_29411_passage",
"type": "progene_text",
"text": [
"The death / C - terminal domain of ankyrin - B determined activity of ankyrin-B / G chimeras in localization in a striated pattern in cardiomyocytes and in restoration of a normal striated distribution of both ryanodine and inositol 1,4,5-trisphosphate receptors as well as normal beat frequency of contracting cardiomyocytes ."
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"offsets": [
[
0,
327
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]
}
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[
{
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"text": [
"ankyrin - B"
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[
35,
46
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{
"id": "split_0_train_47571_entity",
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"ankyrin-B / G"
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70,
83
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{
"id": "split_0_train_47572_entity",
"type": "progene_text",
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"ryanodine and inositol 1,4,5-trisphosphate receptors"
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"offsets": [
[
210,
262
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29412
|
split_0_train_29412
|
[
{
"id": "split_0_train_29412_passage",
"type": "progene_text",
"text": [
"Further deletions within the death / C - terminal domain demonstrated that the C - terminal domain determines ankyrin - B activity , whereas deletion of the death domain had no effect ."
],
"offsets": [
[
0,
185
]
]
}
] |
[
{
"id": "split_0_train_47573_entity",
"type": "progene_text",
"text": [
"ankyrin - B"
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"offsets": [
[
110,
121
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29413
|
split_0_train_29413
|
[
{
"id": "split_0_train_29413_passage",
"type": "progene_text",
"text": [
"C - terminal domains are the most divergent between ankyrin isoforms and are candidates to encode the signal(s) that enable ankyrins to selectively target proteins to diverse cellular sites ."
],
"offsets": [
[
0,
191
]
]
}
] |
[
{
"id": "split_0_train_47574_entity",
"type": "progene_text",
"text": [
"ankyrin"
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[
52,
59
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{
"id": "split_0_train_47575_entity",
"type": "progene_text",
"text": [
"ankyrins"
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"offsets": [
[
124,
132
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29414
|
split_0_train_29414
|
[
{
"id": "split_0_train_29414_passage",
"type": "progene_text",
"text": [
"Identification and molecular characterisation of hordoindolines from barley grain ."
],
"offsets": [
[
0,
83
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29415
|
split_0_train_29415
|
[
{
"id": "split_0_train_29415_passage",
"type": "progene_text",
"text": [
"Grain texture in barley is an important quality character as soft - textured cultivars have better malting quality ."
],
"offsets": [
[
0,
116
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29416
|
split_0_train_29416
|
[
{
"id": "split_0_train_29416_passage",
"type": "progene_text",
"text": [
"In wheat , texture is considered to be determined by the puroindolines , a group of basic hydrophobic proteins present on the surface of the starch granule ."
],
"offsets": [
[
0,
157
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29417
|
split_0_train_29417
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[
{
"id": "split_0_train_29417_passage",
"type": "progene_text",
"text": [
"Hard wheats have been proposed to lack puroindoline a or to have mutant forms of puroindoline b which do not bind to the granule surface ."
],
"offsets": [
[
0,
138
]
]
}
] |
[
{
"id": "split_0_train_47576_entity",
"type": "progene_text",
"text": [
"puroindoline a"
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[
39,
53
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{
"id": "split_0_train_47577_entity",
"type": "progene_text",
"text": [
"puroindoline b"
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"offsets": [
[
81,
95
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29418
|
split_0_train_29418
|
[
{
"id": "split_0_train_29418_passage",
"type": "progene_text",
"text": [
"Analysis of six barley cultivars ( three soft - textured and three hard ) showed that all contained proteins homologous to wheat puroindoline b , but PCR analysis failed to show any differences in amino acid sequences similar to those which have been proposed to determine textural differences in wheat ."
],
"offsets": [
[
0,
304
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]
}
] |
[
{
"id": "split_0_train_47578_entity",
"type": "progene_text",
"text": [
"puroindoline b"
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"offsets": [
[
129,
143
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29419
|
split_0_train_29419
|
[
{
"id": "split_0_train_29419_passage",
"type": "progene_text",
"text": [
"Southern blot analysis showed two hordoindoline b genes which were isolated and shown to encode proteins with 94 % sequence identity ."
],
"offsets": [
[
0,
134
]
]
}
] |
[
{
"id": "split_0_train_47579_entity",
"type": "progene_text",
"text": [
"hordoindoline b"
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"offsets": [
[
34,
49
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29420
|
split_0_train_29420
|
[
{
"id": "split_0_train_29420_passage",
"type": "progene_text",
"text": [
"Expression of hordoindoline b mRNA occurred in the starchy endosperm and aleurone layer of the developing seed , but not in the embryo ."
],
"offsets": [
[
0,
136
]
]
}
] |
[
{
"id": "split_0_train_47580_entity",
"type": "progene_text",
"text": [
"hordoindoline b"
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"offsets": [
[
14,
29
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29421
|
split_0_train_29421
|
[
{
"id": "split_0_train_29421_passage",
"type": "progene_text",
"text": [
"Analysis of seven soft - and six hard - textured barley varieties showed that all contained hordoindoline a except two hard varieties ( Sundance , Hart ) which were subsequently shown to both lack hordoindoline a mRNA ."
],
"offsets": [
[
0,
219
]
]
}
] |
[
{
"id": "split_0_train_47581_entity",
"type": "progene_text",
"text": [
"hordoindoline"
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"offsets": [
[
92,
105
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],
"normalized": []
},
{
"id": "split_0_train_47582_entity",
"type": "progene_text",
"text": [
"hordoindoline a"
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"offsets": [
[
197,
212
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29422
|
split_0_train_29422
|
[
{
"id": "split_0_train_29422_passage",
"type": "progene_text",
"text": [
"It was therefore concluded that there is not a clear relationship between the presence of hordoindoline a and grain texture in barley ."
],
"offsets": [
[
0,
135
]
]
}
] |
[
{
"id": "split_0_train_47583_entity",
"type": "progene_text",
"text": [
"hordoindoline"
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"offsets": [
[
90,
103
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29423
|
split_0_train_29423
|
[
{
"id": "split_0_train_29423_passage",
"type": "progene_text",
"text": [
"Antiapoptotic proteins ."
],
"offsets": [
[
0,
24
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29424
|
split_0_train_29424
|
[
{
"id": "split_0_train_29424_passage",
"type": "progene_text",
"text": [
"The bcl-2 and inhibitor of apoptosis protein families ."
],
"offsets": [
[
0,
55
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]
}
] |
[
{
"id": "split_0_train_47584_entity",
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"text": [
"bcl-2 and inhibitor of apoptosis protein families"
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"offsets": [
[
4,
53
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29425
|
split_0_train_29425
|
[
{
"id": "split_0_train_29425_passage",
"type": "progene_text",
"text": [
"The balance between pro - and antiapoptotic proteins can determine cellular fate ."
],
"offsets": [
[
0,
82
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29426
|
split_0_train_29426
|
[
{
"id": "split_0_train_29426_passage",
"type": "progene_text",
"text": [
"In this regard , the Bcl-2 and IAP protein families have evolved as highly conserved regulators of cell death ."
],
"offsets": [
[
0,
111
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]
}
] |
[
{
"id": "split_0_train_47585_entity",
"type": "progene_text",
"text": [
"Bcl-2 and IAP protein families"
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"offsets": [
[
21,
51
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29427
|
split_0_train_29427
|
[
{
"id": "split_0_train_29427_passage",
"type": "progene_text",
"text": [
"A further testament to their critical roles in maintaining balance between cell life and death may be the increasing implication of Bcl-2 and TAP proteins in the pathologies of human diseases ."
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[
0,
193
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]
}
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[
{
"id": "split_0_train_47586_entity",
"type": "progene_text",
"text": [
"Bcl-2"
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[
132,
137
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{
"id": "split_0_train_47587_entity",
"type": "progene_text",
"text": [
"TAP"
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"offsets": [
[
142,
145
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29428
|
split_0_train_29428
|
[
{
"id": "split_0_train_29428_passage",
"type": "progene_text",
"text": [
"Although much has been learned about these families of proteins , future studies of the Bcl-2 and IAP families are sure to hold more exciting discoveries and will continue to reveal new strategies for combating human diseases ."
],
"offsets": [
[
0,
227
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]
}
] |
[
{
"id": "split_0_train_47588_entity",
"type": "progene_text",
"text": [
"Bcl-2 and IAP families"
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"offsets": [
[
88,
110
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29429
|
split_0_train_29429
|
[
{
"id": "split_0_train_29429_passage",
"type": "progene_text",
"text": [
"Manipulation of hyaluronan synthase expression in prostate adenocarcinoma cells alters pericellular matrix retention and adhesion to bone marrow endothelial cells ."
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"offsets": [
[
0,
164
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]
}
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[
{
"id": "split_0_train_47589_entity",
"type": "progene_text",
"text": [
"hyaluronan synthase"
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"offsets": [
[
16,
35
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29430
|
split_0_train_29430
|
[
{
"id": "split_0_train_29430_passage",
"type": "progene_text",
"text": [
"Prostate cancer metastasis to bone marrow involves initial adhesion of tumor cells to the bone marrow endothelium , followed by transmigration and proliferation within the marrow ."
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0,
180
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29431
|
split_0_train_29431
|
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"text": [
"Rapid , specific adhesion of highly metastatic prostate adenocarcinoma cells ( PC3M-LN4 ) to bone marrow endothelial cell ( BMEC ) lines requires a pericellular hyaluronan ( HA ) matrix and correlates with dramatically up - regulated HA synthase ( HAS ) expression ."
],
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0,
266
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]
}
] |
[
{
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"text": [
"HAS"
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248,
251
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}
] |
[] |
[] |
[] |
split_0_train_29432
|
split_0_train_29432
|
[
{
"id": "split_0_train_29432_passage",
"type": "progene_text",
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"Non - metastatic prostate tumor cells ( LNCaP ) do not assemble a HA matrix , adhere poorly to BMECs , and express normal levels of HAS ."
],
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[
0,
137
]
]
}
] |
[
{
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"type": "progene_text",
"text": [
"HAS"
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[
132,
135
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29433
|
split_0_train_29433
|
[
{
"id": "split_0_train_29433_passage",
"type": "progene_text",
"text": [
"Preferential bone metastasis of prostate carcinoma cells may therefore be facilitated by tumor cell HA biosynthesis ."
],
"offsets": [
[
0,
117
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29434
|
split_0_train_29434
|
[
{
"id": "split_0_train_29434_passage",
"type": "progene_text",
"text": [
"In this report , HAS gene expression was manipulated to investigate the direct impact of prostate tumor cell HA production on adhesion to BMECs ."
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[
0,
145
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]
}
] |
[
{
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"text": [
"HAS"
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[
17,
20
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}
] |
[] |
[] |
[] |
split_0_train_29435
|
split_0_train_29435
|
[
{
"id": "split_0_train_29435_passage",
"type": "progene_text",
"text": [
"PC3M-LN4 cells stably transfected with antisense HAS2 and HAS3 failed to form pericellular matrices ."
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[
0,
101
]
]
}
] |
[
{
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"text": [
"HAS3"
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[
58,
62
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29436
|
split_0_train_29436
|
[
{
"id": "split_0_train_29436_passage",
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"text": [
"Adhesion of these transfectants to BMECs was significantly diminished , comparable to the low level exhibited by LNCaP cells ."
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[
0,
126
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29437
|
split_0_train_29437
|
[
{
"id": "split_0_train_29437_passage",
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"Upon transfection with full-length HAS2 or HAS3 , the non - adherent LNCaP cells retained pericellular HA and adhered to BMECs ."
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0,
128
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]
}
] |
[
{
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35,
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"text": [
"HAS3"
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43,
47
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"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29438
|
split_0_train_29438
|
[
{
"id": "split_0_train_29438_passage",
"type": "progene_text",
"text": [
"The results of this study are consistent with a model in which HA matrix formation , BMEC adhesion , and metastatic potential are mediated by HAS expression ."
],
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0,
158
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]
}
] |
[
{
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"text": [
"HAS"
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142,
145
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}
] |
[] |
[] |
[] |
split_0_train_29439
|
split_0_train_29439
|
[
{
"id": "split_0_train_29439_passage",
"type": "progene_text",
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"CD40 ligation induces macrophage IL-10 and TNF-alpha production : differential use of the PI3K and p42 / 44 MAPK - pathways ."
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0,
125
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}
] |
[
{
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"text": [
"p42 / 44 MAPK"
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[
99,
112
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29440
|
split_0_train_29440
|
[
{
"id": "split_0_train_29440_passage",
"type": "progene_text",
"text": [
"Interleukin 10 ( IL-10 ) is an anti - inflammatory cytokine produced in the rheumatoid arthritis ( RA ) joint by macrophages / monocytes and infiltrating peripheral blood derived lymphocytes ."
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0,
192
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]
}
] |
[
{
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"text": [
"cytokine"
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"offsets": [
[
51,
59
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29441
|
split_0_train_29441
|
[
{
"id": "split_0_train_29441_passage",
"type": "progene_text",
"text": [
"Recent data suggest a role for physical cell - to - cell interactions in the production of IL-10 ."
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0,
98
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}
] |
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{
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"type": "progene_text",
"text": [
"IL-10"
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"offsets": [
[
91,
96
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29442
|
split_0_train_29442
|
[
{
"id": "split_0_train_29442_passage",
"type": "progene_text",
"text": [
"In this report , we have investigated the signalling mechanisms involved in IL-10 production by peripheral blood - derived macrophages upon interaction with fixed CD40L transfectants ."
],
"offsets": [
[
0,
184
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]
}
] |
[
{
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76,
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"type": "progene_text",
"text": [
"CD40L"
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"offsets": [
[
163,
168
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29443
|
split_0_train_29443
|
[
{
"id": "split_0_train_29443_passage",
"type": "progene_text",
"text": [
"IL-10 and tumour necrosis factor alpha ( TNF-alpha ) are produced by macrophage colony - stimulating factor ( M-CSF ) - primed monocytes / macrophages in response to CD40 ligation ."
],
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[
0,
181
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]
}
] |
[
{
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{
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110,
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"type": "progene_text",
"text": [
"CD40"
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"offsets": [
[
166,
170
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29444
|
split_0_train_29444
|
[
{
"id": "split_0_train_29444_passage",
"type": "progene_text",
"text": [
"The utilization of the inhibitors , wortmannin and LY294002 , demonstrated a role for phosphatidylinositol 3-kinase ( PI3K ) whereas rapamycin demonstrated p70 S6 - kinase ( p70S6K ) involvement in the production of IL-10 by these monocytes ."
],
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0,
242
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]
}
] |
[
{
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"text": [
"IL-10"
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216,
221
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29445
|
split_0_train_29445
|
[
{
"id": "split_0_train_29445_passage",
"type": "progene_text",
"text": [
"The production of TNF-alpha was enhanced by wortmannin and LY294002 , suggesting negative regulation by PI3K ; however , it was dependent on p70S6K suggesting a PI3K - independent mechanism of p70S6K activation ."
],
"offsets": [
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0,
212
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]
}
] |
[
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"type": "progene_text",
"text": [
"PI3K"
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"offsets": [
[
161,
165
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29446
|
split_0_train_29446
|
[
{
"id": "split_0_train_29446_passage",
"type": "progene_text",
"text": [
"One alternative pathway that activates p70S6K independently of PI3K and also differentiates between IL-10 and TNF-alpha is the p42 / 44 mitogen - activated protein kinase ( MAPK ) , which regulates TNF-alpha production in a PI3K - independent manner ."
],
"offsets": [
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0,
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]
}
] |
[
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{
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{
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"type": "progene_text",
"text": [
"PI3K"
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"offsets": [
[
224,
228
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29447
|
split_0_train_29447
|
[
{
"id": "split_0_train_29447_passage",
"type": "progene_text",
"text": [
"These observations suggest that CD40 ligation induces macrophage IL-10 and TNF-alpha production , the mechanism of which is p70S6K - dependent yet bifurcates at the level of PI3K and p42 / 44 MAPK ."
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[
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198
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]
}
] |
[
{
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{
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{
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{
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{
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174,
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{
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"type": "progene_text",
"text": [
"p42 / 44 MAPK"
],
"offsets": [
[
183,
196
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29448
|
split_0_train_29448
|
[
{
"id": "split_0_train_29448_passage",
"type": "progene_text",
"text": [
"Regulated trafficking of neurotransmitter transporters : common notes but different melodies ."
],
"offsets": [
[
0,
94
]
]
}
] |
[
{
"id": "split_0_train_47639_entity",
"type": "progene_text",
"text": [
"neurotransmitter transporters"
],
"offsets": [
[
25,
54
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29449
|
split_0_train_29449
|
[
{
"id": "split_0_train_29449_passage",
"type": "progene_text",
"text": [
"The activity of biogenic amine and amino acid neurotransmitters is limited by presynaptic and astrocytic Na ( + ) - dependent transport systems ."
],
"offsets": [
[
0,
145
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29450
|
split_0_train_29450
|
[
{
"id": "split_0_train_29450_passage",
"type": "progene_text",
"text": [
"Their functional importance is underscored by the observation that these transporters are the targets of broad classes of psychotherapeutic agents , including antidepressants and stimulants ."
],
"offsets": [
[
0,
191
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29451
|
split_0_train_29451
|
[
{
"id": "split_0_train_29451_passage",
"type": "progene_text",
"text": [
"Early studies suggested that the activity of these transporters can be fine tuned by a number of different signaling pathways ."
],
"offsets": [
[
0,
127
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29452
|
split_0_train_29452
|
[
{
"id": "split_0_train_29452_passage",
"type": "progene_text",
"text": [
"In the past five years , several groups have provided compelling evidence that changing the cell surface availability of these transporters contributes to this fine tuning ."
],
"offsets": [
[
0,
173
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29453
|
split_0_train_29453
|
[
{
"id": "split_0_train_29453_passage",
"type": "progene_text",
"text": [
"This regulated trafficking can result in rapid ( within minutes ) increases or decreases in the plasma membrane expression of these transporters and is independent of transcriptional or translational control mechanisms ."
],
"offsets": [
[
0,
220
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29454
|
split_0_train_29454
|
[
{
"id": "split_0_train_29454_passage",
"type": "progene_text",
"text": [
"Many of the same signaling molecules , including protein kinase C ( PKC ) , tyrosine kinase , phosphatidylinositol 3-kinase ( P13 - K ) , and protein phosphatase , regulate the transporters for different neurotransmitters ."
],
"offsets": [
[
0,
223
]
]
}
] |
[
{
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{
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{
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{
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{
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},
{
"id": "split_0_train_47645_entity",
"type": "progene_text",
"text": [
"protein phosphatase"
],
"offsets": [
[
142,
161
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29455
|
split_0_train_29455
|
[
{
"id": "split_0_train_29455_passage",
"type": "progene_text",
"text": [
"In addition to these classical receptor activated pathways , transporter substrates also regulate activity and cell surface expression of these transporters ."
],
"offsets": [
[
0,
158
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29456
|
split_0_train_29456
|
[
{
"id": "split_0_train_29456_passage",
"type": "progene_text",
"text": [
"In fact , some of the transporters form complexes with signaling molecules ."
],
"offsets": [
[
0,
76
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29457
|
split_0_train_29457
|
[
{
"id": "split_0_train_29457_passage",
"type": "progene_text",
"text": [
"Given the functional and genetic similarities of these transporters , it is not surprising that the same signaling molecules regulate their trafficking , but except for the molecules , the actual effects on individual transporters are remarkably different ."
],
"offsets": [
[
0,
257
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29458
|
split_0_train_29458
|
[
{
"id": "split_0_train_29458_passage",
"type": "progene_text",
"text": [
"It is as if the same musical notes have been rearranged into several different melodies ."
],
"offsets": [
[
0,
89
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29459
|
split_0_train_29459
|
[
{
"id": "split_0_train_29459_passage",
"type": "progene_text",
"text": [
"Fc alpha RI / CD89 circulates in human serum covalently linked to IgA in a polymeric state ."
],
"offsets": [
[
0,
92
]
]
}
] |
[
{
"id": "split_0_train_47646_entity",
"type": "progene_text",
"text": [
"Fc alpha RI"
],
"offsets": [
[
0,
11
]
],
"normalized": []
},
{
"id": "split_0_train_47647_entity",
"type": "progene_text",
"text": [
"CD89"
],
"offsets": [
[
14,
18
]
],
"normalized": []
},
{
"id": "split_0_train_47648_entity",
"type": "progene_text",
"text": [
"IgA"
],
"offsets": [
[
66,
69
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29460
|
split_0_train_29460
|
[
{
"id": "split_0_train_29460_passage",
"type": "progene_text",
"text": [
"The FcR for IgA CD89 / FcalphaRI , is a type I receptor glycoprotein , expressed on myeloid cells , with important immune effector functions ."
],
"offsets": [
[
0,
142
]
]
}
] |
[
{
"id": "split_0_train_47649_entity",
"type": "progene_text",
"text": [
"FcR for IgA"
],
"offsets": [
[
4,
15
]
],
"normalized": []
},
{
"id": "split_0_train_47650_entity",
"type": "progene_text",
"text": [
"CD89"
],
"offsets": [
[
16,
20
]
],
"normalized": []
},
{
"id": "split_0_train_47651_entity",
"type": "progene_text",
"text": [
"FcalphaRI"
],
"offsets": [
[
23,
32
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29461
|
split_0_train_29461
|
[
{
"id": "split_0_train_29461_passage",
"type": "progene_text",
"text": [
"In vitro CD89 can be released from CD89 - expressing cells upon activation ."
],
"offsets": [
[
0,
76
]
]
}
] |
[
{
"id": "split_0_train_47652_entity",
"type": "progene_text",
"text": [
"CD89"
],
"offsets": [
[
9,
13
]
],
"normalized": []
},
{
"id": "split_0_train_47653_entity",
"type": "progene_text",
"text": [
"CD89"
],
"offsets": [
[
35,
39
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29462
|
split_0_train_29462
|
[
{
"id": "split_0_train_29462_passage",
"type": "progene_text",
"text": [
"Little information is available on the existence of this soluble molecule in vivo ."
],
"offsets": [
[
0,
83
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29463
|
split_0_train_29463
|
[
{
"id": "split_0_train_29463_passage",
"type": "progene_text",
"text": [
"Using specific and sensitive ELISA techniques ( detection limit 50 pg / ml ) , we were not able to detect circulating CD89 in human sera ."
],
"offsets": [
[
0,
138
]
]
}
] |
[
{
"id": "split_0_train_47654_entity",
"type": "progene_text",
"text": [
"CD89"
],
"offsets": [
[
118,
122
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29464
|
split_0_train_29464
|
[
{
"id": "split_0_train_29464_passage",
"type": "progene_text",
"text": [
"However , using Western blotting , a 30 - kDa soluble CD89 molecule was demonstrated in both serum and plasma ."
],
"offsets": [
[
0,
111
]
]
}
] |
[
{
"id": "split_0_train_47655_entity",
"type": "progene_text",
"text": [
"CD89"
],
"offsets": [
[
54,
58
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29465
|
split_0_train_29465
|
[
{
"id": "split_0_train_29465_passage",
"type": "progene_text",
"text": [
"Moreover , using a specific semiquantitative dot - blot system , we found CD89 in all human sera tested ( mean concentration 1900 ng / ml ) ."
],
"offsets": [
[
0,
141
]
]
}
] |
[
{
"id": "split_0_train_47656_entity",
"type": "progene_text",
"text": [
"CD89"
],
"offsets": [
[
74,
78
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29466
|
split_0_train_29466
|
[
{
"id": "split_0_train_29466_passage",
"type": "progene_text",
"text": [
"Size fractionation of human serum using gel filtration chromatography showed that the CD89 molecule was predominantly present in larger molecular mass fractions ."
],
"offsets": [
[
0,
162
]
]
}
] |
[
{
"id": "split_0_train_47657_entity",
"type": "progene_text",
"text": [
"CD89"
],
"offsets": [
[
86,
90
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29467
|
split_0_train_29467
|
[
{
"id": "split_0_train_29467_passage",
"type": "progene_text",
"text": [
"Direct complexes between IgA and CD89 were demonstrated by anti - IgA affinity purification , and when analyzed under nonreducing conditions appeared to be covalently linked ."
],
"offsets": [
[
0,
175
]
]
}
] |
[
{
"id": "split_0_train_47658_entity",
"type": "progene_text",
"text": [
"IgA"
],
"offsets": [
[
25,
28
]
],
"normalized": []
},
{
"id": "split_0_train_47659_entity",
"type": "progene_text",
"text": [
"CD89"
],
"offsets": [
[
33,
37
]
],
"normalized": []
},
{
"id": "split_0_train_47660_entity",
"type": "progene_text",
"text": [
"IgA"
],
"offsets": [
[
66,
69
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29468
|
split_0_train_29468
|
[
{
"id": "split_0_train_29468_passage",
"type": "progene_text",
"text": [
"Size fractionation of affinity - purified IgA showed the presence of soluble CD89 only in the high molecular mass fractions of IgA , but not in monomeric IgA ."
],
"offsets": [
[
0,
159
]
]
}
] |
[
{
"id": "split_0_train_47661_entity",
"type": "progene_text",
"text": [
"IgA"
],
"offsets": [
[
42,
45
]
],
"normalized": []
},
{
"id": "split_0_train_47662_entity",
"type": "progene_text",
"text": [
"CD89"
],
"offsets": [
[
77,
81
]
],
"normalized": []
},
{
"id": "split_0_train_47663_entity",
"type": "progene_text",
"text": [
"IgA"
],
"offsets": [
[
127,
130
]
],
"normalized": []
},
{
"id": "split_0_train_47664_entity",
"type": "progene_text",
"text": [
"IgA"
],
"offsets": [
[
154,
157
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29469
|
split_0_train_29469
|
[
{
"id": "split_0_train_29469_passage",
"type": "progene_text",
"text": [
"High molecular mass complexes of CD89 - IgA could be distinguished from J chain containing dimeric IgA ."
],
"offsets": [
[
0,
104
]
]
}
] |
[
{
"id": "split_0_train_47665_entity",
"type": "progene_text",
"text": [
"CD89"
],
"offsets": [
[
33,
37
]
],
"normalized": []
},
{
"id": "split_0_train_47666_entity",
"type": "progene_text",
"text": [
"IgA"
],
"offsets": [
[
40,
43
]
],
"normalized": []
},
{
"id": "split_0_train_47667_entity",
"type": "progene_text",
"text": [
"IgA"
],
"offsets": [
[
99,
102
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29470
|
split_0_train_29470
|
[
{
"id": "split_0_train_29470_passage",
"type": "progene_text",
"text": [
"These data show that CD89 circulates in complex with IgA , and suggest that CD89 might contribute to the formation of polymeric serum IgA ."
],
"offsets": [
[
0,
139
]
]
}
] |
[
{
"id": "split_0_train_47668_entity",
"type": "progene_text",
"text": [
"CD89"
],
"offsets": [
[
21,
25
]
],
"normalized": []
},
{
"id": "split_0_train_47669_entity",
"type": "progene_text",
"text": [
"IgA"
],
"offsets": [
[
53,
56
]
],
"normalized": []
},
{
"id": "split_0_train_47670_entity",
"type": "progene_text",
"text": [
"CD89"
],
"offsets": [
[
76,
80
]
],
"normalized": []
},
{
"id": "split_0_train_47671_entity",
"type": "progene_text",
"text": [
"IgA"
],
"offsets": [
[
134,
137
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29471
|
split_0_train_29471
|
[
{
"id": "split_0_train_29471_passage",
"type": "progene_text",
"text": [
"Insulin - degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain ( AICD ) ."
],
"offsets": [
[
0,
109
]
]
}
] |
[
{
"id": "split_0_train_47672_entity",
"type": "progene_text",
"text": [
"Insulin - degrading enzyme"
],
"offsets": [
[
0,
26
]
],
"normalized": []
},
{
"id": "split_0_train_47673_entity",
"type": "progene_text",
"text": [
"beta-amyloid precursor protein intracellular domain"
],
"offsets": [
[
47,
98
]
],
"normalized": []
},
{
"id": "split_0_train_47674_entity",
"type": "progene_text",
"text": [
"AICD"
],
"offsets": [
[
101,
105
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29472
|
split_0_train_29472
|
[
{
"id": "split_0_train_29472_passage",
"type": "progene_text",
"text": [
"The intramembranous gamma - secretase cleavage of the beta-amyloid precursor protein ( APP ) is dependent on biologically active presenilins ( PS ) ."
],
"offsets": [
[
0,
149
]
]
}
] |
[
{
"id": "split_0_train_47675_entity",
"type": "progene_text",
"text": [
"gamma - secretase"
],
"offsets": [
[
20,
37
]
],
"normalized": []
},
{
"id": "split_0_train_47676_entity",
"type": "progene_text",
"text": [
"beta-amyloid precursor protein"
],
"offsets": [
[
54,
84
]
],
"normalized": []
},
{
"id": "split_0_train_47677_entity",
"type": "progene_text",
"text": [
"APP"
],
"offsets": [
[
87,
90
]
],
"normalized": []
},
{
"id": "split_0_train_47678_entity",
"type": "progene_text",
"text": [
"presenilins"
],
"offsets": [
[
129,
140
]
],
"normalized": []
},
{
"id": "split_0_train_47679_entity",
"type": "progene_text",
"text": [
"PS"
],
"offsets": [
[
143,
145
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29473
|
split_0_train_29473
|
[
{
"id": "split_0_train_29473_passage",
"type": "progene_text",
"text": [
"Notch also undergoes a similar PS - dependent gamma - secretase - like cleavage , resulting in the liberation of the Notch intracellular domain ( NICD ) , which is critically required for developmental signal transduction ."
],
"offsets": [
[
0,
223
]
]
}
] |
[
{
"id": "split_0_train_47680_entity",
"type": "progene_text",
"text": [
"Notch"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "split_0_train_47681_entity",
"type": "progene_text",
"text": [
"PS"
],
"offsets": [
[
31,
33
]
],
"normalized": []
},
{
"id": "split_0_train_47682_entity",
"type": "progene_text",
"text": [
"gamma - secretase"
],
"offsets": [
[
46,
63
]
],
"normalized": []
},
{
"id": "split_0_train_47683_entity",
"type": "progene_text",
"text": [
"Notch intracellular domain"
],
"offsets": [
[
117,
143
]
],
"normalized": []
},
{
"id": "split_0_train_47684_entity",
"type": "progene_text",
"text": [
"NICD"
],
"offsets": [
[
146,
150
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29474
|
split_0_train_29474
|
[
{
"id": "split_0_train_29474_passage",
"type": "progene_text",
"text": [
"gamma - Secretase processing of APP results in the production of a similar fragment called AICD ( APP intracellular domain ) , which may function in nuclear signaling as well ."
],
"offsets": [
[
0,
176
]
]
}
] |
[
{
"id": "split_0_train_47685_entity",
"type": "progene_text",
"text": [
"gamma - Secretase"
],
"offsets": [
[
0,
17
]
],
"normalized": []
},
{
"id": "split_0_train_47686_entity",
"type": "progene_text",
"text": [
"APP"
],
"offsets": [
[
32,
35
]
],
"normalized": []
},
{
"id": "split_0_train_47687_entity",
"type": "progene_text",
"text": [
"AICD"
],
"offsets": [
[
91,
95
]
],
"normalized": []
},
{
"id": "split_0_train_47688_entity",
"type": "progene_text",
"text": [
"APP intracellular domain"
],
"offsets": [
[
98,
122
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29475
|
split_0_train_29475
|
[
{
"id": "split_0_train_29475_passage",
"type": "progene_text",
"text": [
"AICD , like NICD , is rapidly removed ."
],
"offsets": [
[
0,
39
]
]
}
] |
[
{
"id": "split_0_train_47689_entity",
"type": "progene_text",
"text": [
"AICD"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_47690_entity",
"type": "progene_text",
"text": [
"NICD"
],
"offsets": [
[
12,
16
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29476
|
split_0_train_29476
|
[
{
"id": "split_0_train_29476_passage",
"type": "progene_text",
"text": [
"By using a battery of protease inhibitors we demonstrate that AICD , in contrast to NICD , is degraded by a cytoplasmic metalloprotease ."
],
"offsets": [
[
0,
137
]
]
}
] |
[
{
"id": "split_0_train_47691_entity",
"type": "progene_text",
"text": [
"protease"
],
"offsets": [
[
22,
30
]
],
"normalized": []
},
{
"id": "split_0_train_47692_entity",
"type": "progene_text",
"text": [
"AICD"
],
"offsets": [
[
62,
66
]
],
"normalized": []
},
{
"id": "split_0_train_47693_entity",
"type": "progene_text",
"text": [
"NICD"
],
"offsets": [
[
84,
88
]
],
"normalized": []
},
{
"id": "split_0_train_47694_entity",
"type": "progene_text",
"text": [
"metalloprotease"
],
"offsets": [
[
120,
135
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29477
|
split_0_train_29477
|
[
{
"id": "split_0_train_29477_passage",
"type": "progene_text",
"text": [
"In vitro degradation of AICD can be reconstituted with cytoplasmic fractions obtained from neuronal and non - neuronal cells ."
],
"offsets": [
[
0,
126
]
]
}
] |
[
{
"id": "split_0_train_47695_entity",
"type": "progene_text",
"text": [
"AICD"
],
"offsets": [
[
24,
28
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29478
|
split_0_train_29478
|
[
{
"id": "split_0_train_29478_passage",
"type": "progene_text",
"text": [
"Taking into account the inhibition profile and the cytoplasmic localization , we identified three candidate enzymes ( neurolysin , thimet oligopeptidase , and insulin - degrading enzyme ( IDE ) , also known as insulysin ) , which all are involved in the degradation of bioactive peptides in the brain ."
],
"offsets": [
[
0,
302
]
]
}
] |
[
{
"id": "split_0_train_47696_entity",
"type": "progene_text",
"text": [
"neurolysin"
],
"offsets": [
[
118,
128
]
],
"normalized": []
},
{
"id": "split_0_train_47697_entity",
"type": "progene_text",
"text": [
"thimet oligopeptidase"
],
"offsets": [
[
131,
152
]
],
"normalized": []
},
{
"id": "split_0_train_47698_entity",
"type": "progene_text",
"text": [
"insulin - degrading enzyme"
],
"offsets": [
[
159,
185
]
],
"normalized": []
},
{
"id": "split_0_train_47699_entity",
"type": "progene_text",
"text": [
"IDE"
],
"offsets": [
[
188,
191
]
],
"normalized": []
},
{
"id": "split_0_train_47700_entity",
"type": "progene_text",
"text": [
"insulysin"
],
"offsets": [
[
210,
219
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29479
|
split_0_train_29479
|
[
{
"id": "split_0_train_29479_passage",
"type": "progene_text",
"text": [
"When insulin , a well characterized substrate of IDE , was added to the in vitro degradation assay , removal of AICD was efficiently blocked ."
],
"offsets": [
[
0,
142
]
]
}
] |
[
{
"id": "split_0_train_47701_entity",
"type": "progene_text",
"text": [
"insulin"
],
"offsets": [
[
5,
12
]
],
"normalized": []
},
{
"id": "split_0_train_47702_entity",
"type": "progene_text",
"text": [
"IDE"
],
"offsets": [
[
49,
52
]
],
"normalized": []
},
{
"id": "split_0_train_47703_entity",
"type": "progene_text",
"text": [
"AICD"
],
"offsets": [
[
112,
116
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29480
|
split_0_train_29480
|
[
{
"id": "split_0_train_29480_passage",
"type": "progene_text",
"text": [
"Moreover , overexpression of IDE resulted in enhanced degradation of AICD , whereas overexpression of the inactive IDE E111Q mutant did not affect AICD degradation ."
],
"offsets": [
[
0,
165
]
]
}
] |
[
{
"id": "split_0_train_47704_entity",
"type": "progene_text",
"text": [
"IDE"
],
"offsets": [
[
29,
32
]
],
"normalized": []
},
{
"id": "split_0_train_47705_entity",
"type": "progene_text",
"text": [
"AICD"
],
"offsets": [
[
69,
73
]
],
"normalized": []
},
{
"id": "split_0_train_47706_entity",
"type": "progene_text",
"text": [
"IDE"
],
"offsets": [
[
115,
118
]
],
"normalized": []
},
{
"id": "split_0_train_47707_entity",
"type": "progene_text",
"text": [
"AICD"
],
"offsets": [
[
147,
151
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29481
|
split_0_train_29481
|
[
{
"id": "split_0_train_29481_passage",
"type": "progene_text",
"text": [
"Finally , immunodepletion of IDE significantly reduced the AICD degrading activity ."
],
"offsets": [
[
0,
84
]
]
}
] |
[
{
"id": "split_0_train_47708_entity",
"type": "progene_text",
"text": [
"IDE"
],
"offsets": [
[
29,
32
]
],
"normalized": []
},
{
"id": "split_0_train_47709_entity",
"type": "progene_text",
"text": [
"AICD"
],
"offsets": [
[
59,
63
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29482
|
split_0_train_29482
|
[
{
"id": "split_0_train_29482_passage",
"type": "progene_text",
"text": [
"Therefore our data demonstrate that IDE , which is one of the proteases implicated in the removal of extracellular Abeta , also removes the cytoplasmic product of gamma-secretase cleaved APP ."
],
"offsets": [
[
0,
192
]
]
}
] |
[
{
"id": "split_0_train_47710_entity",
"type": "progene_text",
"text": [
"IDE"
],
"offsets": [
[
36,
39
]
],
"normalized": []
},
{
"id": "split_0_train_47711_entity",
"type": "progene_text",
"text": [
"proteases"
],
"offsets": [
[
62,
71
]
],
"normalized": []
},
{
"id": "split_0_train_47712_entity",
"type": "progene_text",
"text": [
"Abeta"
],
"offsets": [
[
115,
120
]
],
"normalized": []
},
{
"id": "split_0_train_47713_entity",
"type": "progene_text",
"text": [
"gamma-secretase"
],
"offsets": [
[
163,
178
]
],
"normalized": []
},
{
"id": "split_0_train_47714_entity",
"type": "progene_text",
"text": [
"APP"
],
"offsets": [
[
187,
190
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29483
|
split_0_train_29483
|
[
{
"id": "split_0_train_29483_passage",
"type": "progene_text",
"text": [
"Variations in respiratory muscle activity during echolocation when stationary in three species of bat ( Microchiroptera : Vespertilionidae ) ."
],
"offsets": [
[
0,
142
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29484
|
split_0_train_29484
|
[
{
"id": "split_0_train_29484_passage",
"type": "progene_text",
"text": [
"Echolocating bats use respiratory muscles to power the production of biosonar vocalisations ."
],
"offsets": [
[
0,
93
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29485
|
split_0_train_29485
|
[
{
"id": "split_0_train_29485_passage",
"type": "progene_text",
"text": [
"The physical characteristics of these calls vary among species of bat , and variations also exist in the timing and patterns of respiratory muscle recruitment during echolocation ."
],
"offsets": [
[
0,
180
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29486
|
split_0_train_29486
|
[
{
"id": "split_0_train_29486_passage",
"type": "progene_text",
"text": [
"We recorded electromyograms from the respiratory muscles of three species of bat ( Family Vespertilionidae ) while the animals vocalised from stationary positions ."
],
"offsets": [
[
0,
164
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29487
|
split_0_train_29487
|
[
{
"id": "split_0_train_29487_passage",
"type": "progene_text",
"text": [
"Activity was recorded consistently from the lateral abdominal muscles ( internal abdominal oblique and transversus abdominis ) from all calling bats , but we found much variation within and among species ."
],
"offsets": [
[
0,
205
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29488
|
split_0_train_29488
|
[
{
"id": "split_0_train_29488_passage",
"type": "progene_text",
"text": [
"Bats in the family Vespertilionidae devoted longer periods of expiratory muscle activity to each call than did the mormoopid bat Pteronotus parnellii ."
],
"offsets": [
[
0,
151
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29489
|
split_0_train_29489
|
[
{
"id": "split_0_train_29489_passage",
"type": "progene_text",
"text": [
"These differences correlate negatively with the duration of calls ."
],
"offsets": [
[
0,
67
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29490
|
split_0_train_29490
|
[
{
"id": "split_0_train_29490_passage",
"type": "progene_text",
"text": [
"We suggest that morphological adaptations in some bats may facilitate the economic production of echolocation calls at rest ."
],
"offsets": [
[
0,
125
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29491
|
split_0_train_29491
|
[
{
"id": "split_0_train_29491_passage",
"type": "progene_text",
"text": [
"High serum concentrations of dimeric inhibins A and B in normal newborn girls ."
],
"offsets": [
[
0,
79
]
]
}
] |
[
{
"id": "split_0_train_47715_entity",
"type": "progene_text",
"text": [
"inhibins A and B"
],
"offsets": [
[
37,
53
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29492
|
split_0_train_29492
|
[
{
"id": "split_0_train_29492_passage",
"type": "progene_text",
"text": [
"OBJECTIVE :"
],
"offsets": [
[
0,
11
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29493
|
split_0_train_29493
|
[
{
"id": "split_0_train_29493_passage",
"type": "progene_text",
"text": [
"To establish the serum pattern of dimeric inhibins in normal girls during the newborn period and to examine its relationship with the postnatal gonadotropic surge ."
],
"offsets": [
[
0,
164
]
]
}
] |
[
{
"id": "split_0_train_47716_entity",
"type": "progene_text",
"text": [
"inhibins"
],
"offsets": [
[
42,
50
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29494
|
split_0_train_29494
|
[
{
"id": "split_0_train_29494_passage",
"type": "progene_text",
"text": [
"DESIGN :"
],
"offsets": [
[
0,
8
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29495
|
split_0_train_29495
|
[
{
"id": "split_0_train_29495_passage",
"type": "progene_text",
"text": [
"Retrospective study ."
],
"offsets": [
[
0,
21
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29496
|
split_0_train_29496
|
[
{
"id": "split_0_train_29496_passage",
"type": "progene_text",
"text": [
"SETTING ; Division of endocrinology of a children 's hospital ."
],
"offsets": [
[
0,
63
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29497
|
split_0_train_29497
|
[
{
"id": "split_0_train_29497_passage",
"type": "progene_text",
"text": [
"PATIENT(S) :"
],
"offsets": [
[
0,
12
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29498
|
split_0_train_29498
|
[
{
"id": "split_0_train_29498_passage",
"type": "progene_text",
"text": [
"Thirty-one girls 4 to 65 days of age ."
],
"offsets": [
[
0,
38
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29499
|
split_0_train_29499
|
[
{
"id": "split_0_train_29499_passage",
"type": "progene_text",
"text": [
"MAIN OUTCOME MEASURE(S) :"
],
"offsets": [
[
0,
25
]
]
}
] |
[] |
[] |
[] |
[] |
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