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split_0_train_29200
|
split_0_train_29200
|
[
{
"id": "split_0_train_29200_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29201
|
split_0_train_29201
|
[
{
"id": "split_0_train_29201_passage",
"type": "progene_text",
"text": [
"The QWB-SA and SF-36 were highly correlated ."
],
"offsets": [
[
0,
45
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29202
|
split_0_train_29202
|
[
{
"id": "split_0_train_29202_passage",
"type": "progene_text",
"text": [
"The QWB-SA was systematically related to disease state ."
],
"offsets": [
[
0,
56
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29203
|
split_0_train_29203
|
[
{
"id": "split_0_train_29203_passage",
"type": "progene_text",
"text": [
"Those with no symptomatic evidence had the highest scores followed by those who were stable with no metastatic disease and those with metastatic progression ."
],
"offsets": [
[
0,
158
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29204
|
split_0_train_29204
|
[
{
"id": "split_0_train_29204_passage",
"type": "progene_text",
"text": [
"Similar patterns were found for most SF-36 scales although the SF-36 failed to discriminate between those with no evidence of disease and those with stable disease without metastasis ."
],
"offsets": [
[
0,
184
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29205
|
split_0_train_29205
|
[
{
"id": "split_0_train_29205_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29206
|
split_0_train_29206
|
[
{
"id": "split_0_train_29206_passage",
"type": "progene_text",
"text": [
"Both the QWB-SA and SF-36 perform as expected using German language translations ."
],
"offsets": [
[
0,
82
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29207
|
split_0_train_29207
|
[
{
"id": "split_0_train_29207_passage",
"type": "progene_text",
"text": [
"Although both measures differentiate patients with metastasis from those without symptoms , the QWB-SA better differentiated those with no evidence of disease from those with stable disease without metastasis ."
],
"offsets": [
[
0,
210
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29208
|
split_0_train_29208
|
[
{
"id": "split_0_train_29208_passage",
"type": "progene_text",
"text": [
"Relation between blood pressure variability and carotid artery damage in hypertension : baseline data from the European Lacidipine Study on Atherosclerosis ( ELSA ) ."
],
"offsets": [
[
0,
166
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29209
|
split_0_train_29209
|
[
{
"id": "split_0_train_29209_passage",
"type": "progene_text",
"text": [
"BACKGROUND :"
],
"offsets": [
[
0,
12
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29210
|
split_0_train_29210
|
[
{
"id": "split_0_train_29210_passage",
"type": "progene_text",
"text": [
"Baseline data from the European Lacidipine Study on Atherosclerosis ( ELSA ) have shown that carotid intima - media thickness ( IMT ) is not related to diastolic blood pressure ( BP ) , but that it is related to clinic systolic (S) or pulse pressure ( PP ) and more so to their 24 h average values ."
],
"offsets": [
[
0,
299
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29211
|
split_0_train_29211
|
[
{
"id": "split_0_train_29211_passage",
"type": "progene_text",
"text": [
"The aim of the present study was to determine whether IMT independently relates to additional information obtained through ambulatory BP , in particular to SBP or PP variability ."
],
"offsets": [
[
0,
179
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29212
|
split_0_train_29212
|
[
{
"id": "split_0_train_29212_passage",
"type": "progene_text",
"text": [
"METHODS AND RESULTS : In 1663 hypertensive patients , after a wash - out period from antihypertensive treatment ( mean age 56.2 +/- 7.65 years ) , IMT was assessed from 12 different carotid sites ."
],
"offsets": [
[
0,
197
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29213
|
split_0_train_29213
|
[
{
"id": "split_0_train_29213_passage",
"type": "progene_text",
"text": [
"Ambulatory BP measurements were performed every 15 min ( day ) and every 20 min ( night ) ."
],
"offsets": [
[
0,
91
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29214
|
split_0_train_29214
|
[
{
"id": "split_0_train_29214_passage",
"type": "progene_text",
"text": [
"IMT values were positively related to 24 h , day and night average SBP and PP ."
],
"offsets": [
[
0,
79
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29215
|
split_0_train_29215
|
[
{
"id": "split_0_train_29215_passage",
"type": "progene_text",
"text": [
"There was some relationship of IMT with day - night or clinic - day SBP and PP differences ."
],
"offsets": [
[
0,
92
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29216
|
split_0_train_29216
|
[
{
"id": "split_0_train_29216_passage",
"type": "progene_text",
"text": [
"The most important finding , however , was that IMT values were related with 24 h SBP or PP standard deviation ( P < 0.001 ) , a measure of overall SBP or PP variability ."
],
"offsets": [
[
0,
171
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29217
|
split_0_train_29217
|
[
{
"id": "split_0_train_29217_passage",
"type": "progene_text",
"text": [
"The relationship was seen also by multiple regression analysis , the standard deviation for SBP or PP only following age and 24 h average SBP or PP in accounting for IMT values ."
],
"offsets": [
[
0,
178
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29218
|
split_0_train_29218
|
[
{
"id": "split_0_train_29218_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS : This is the first demonstration from a large database that not only average 24 h PP and SBP values , but also 24 h BP fluctuations , are associated with , and possibly determinants of , the alterations of large artery structure in hypertension ."
],
"offsets": [
[
0,
259
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29219
|
split_0_train_29219
|
[
{
"id": "split_0_train_29219_passage",
"type": "progene_text",
"text": [
"The maternal gene spn-4 encodes a predicted RRM protein required for mitotic spindle orientation and cell fate patterning in early C. elegans embryos ."
],
"offsets": [
[
0,
151
]
]
}
] |
[
{
"id": "split_0_train_47462_entity",
"type": "progene_text",
"text": [
"spn-4"
],
"offsets": [
[
18,
23
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29220
|
split_0_train_29220
|
[
{
"id": "split_0_train_29220_passage",
"type": "progene_text",
"text": [
"C. elegans embryogenesis begins with a stereotyped sequence of asymmetric cell divisions that are largely responsible for establishing the nematode body plan ."
],
"offsets": [
[
0,
159
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29221
|
split_0_train_29221
|
[
{
"id": "split_0_train_29221_passage",
"type": "progene_text",
"text": [
"These early asymmetries are specified after fertilization by the widely conserved , cortically enriched PAR and PKC-3 proteins , which include three kinases and two PDZ domain proteins ."
],
"offsets": [
[
0,
186
]
]
}
] |
[
{
"id": "split_0_train_47463_entity",
"type": "progene_text",
"text": [
"PAR"
],
"offsets": [
[
104,
107
]
],
"normalized": []
},
{
"id": "split_0_train_47464_entity",
"type": "progene_text",
"text": [
"PKC-3"
],
"offsets": [
[
112,
117
]
],
"normalized": []
},
{
"id": "split_0_train_47465_entity",
"type": "progene_text",
"text": [
"kinases"
],
"offsets": [
[
149,
156
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29222
|
split_0_train_29222
|
[
{
"id": "split_0_train_29222_passage",
"type": "progene_text",
"text": [
"During asymmetric cell divisions in the early embryo , centrosome pairs initially are positioned on transverse axes but then rotate to align with the anteroposterior embryonic axis ."
],
"offsets": [
[
0,
182
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29223
|
split_0_train_29223
|
[
{
"id": "split_0_train_29223_passage",
"type": "progene_text",
"text": [
"We show that rotation of the centrosomal / nuclear complex in an embryonic cell called P(1) requires a maternally expressed gene we name spn - 4 ."
],
"offsets": [
[
0,
146
]
]
}
] |
[
{
"id": "split_0_train_47466_entity",
"type": "progene_text",
"text": [
"spn - 4"
],
"offsets": [
[
137,
144
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29224
|
split_0_train_29224
|
[
{
"id": "split_0_train_29224_passage",
"type": "progene_text",
"text": [
"The predicted SPN-4 protein contains a single RNA recognition motif ( RRM ) , and belongs to a small subfamily of RRM proteins that includes one Drosophila and two human family members ."
],
"offsets": [
[
0,
186
]
]
}
] |
[
{
"id": "split_0_train_47467_entity",
"type": "progene_text",
"text": [
"SPN-4"
],
"offsets": [
[
14,
19
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29225
|
split_0_train_29225
|
[
{
"id": "split_0_train_29225_passage",
"type": "progene_text",
"text": [
"Remarkably , in mutant embryos lacking spn-4 function the transversely oriented ' P(1)' mitotic spindle appears to re - specify the axis of cell polarity , and the division remains asymmetric ."
],
"offsets": [
[
0,
193
]
]
}
] |
[
{
"id": "split_0_train_47468_entity",
"type": "progene_text",
"text": [
"spn-4"
],
"offsets": [
[
39,
44
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29226
|
split_0_train_29226
|
[
{
"id": "split_0_train_29226_passage",
"type": "progene_text",
"text": [
"spn-4 also is required for other developmental processes , including the specification of mesendoderm , the restriction of mesectoderm fate to P(1) descendants , and germline quiescence during embryogenesis ."
],
"offsets": [
[
0,
208
]
]
}
] |
[
{
"id": "split_0_train_47469_entity",
"type": "progene_text",
"text": [
"spn-4"
],
"offsets": [
[
0,
5
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29227
|
split_0_train_29227
|
[
{
"id": "split_0_train_29227_passage",
"type": "progene_text",
"text": [
"We suggest that SPN-4 post - transcriptionally regulates the expression of multiple developmental regulators ."
],
"offsets": [
[
0,
110
]
]
}
] |
[
{
"id": "split_0_train_47470_entity",
"type": "progene_text",
"text": [
"SPN-4"
],
"offsets": [
[
16,
21
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29228
|
split_0_train_29228
|
[
{
"id": "split_0_train_29228_passage",
"type": "progene_text",
"text": [
"Such SPN-4 targets might then act more specifically to generate a subset of the anterior - posterior asymmetries initially specified after fertilization by the more generally required PAR and PKC-3 proteins ."
],
"offsets": [
[
0,
208
]
]
}
] |
[
{
"id": "split_0_train_47471_entity",
"type": "progene_text",
"text": [
"SPN-4"
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"offsets": [
[
5,
10
]
],
"normalized": []
},
{
"id": "split_0_train_47472_entity",
"type": "progene_text",
"text": [
"PAR"
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"offsets": [
[
184,
187
]
],
"normalized": []
},
{
"id": "split_0_train_47473_entity",
"type": "progene_text",
"text": [
"PKC-3"
],
"offsets": [
[
192,
197
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29229
|
split_0_train_29229
|
[
{
"id": "split_0_train_29229_passage",
"type": "progene_text",
"text": [
"Ulcerative colitis and sarcoidosis ."
],
"offsets": [
[
0,
36
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29230
|
split_0_train_29230
|
[
{
"id": "split_0_train_29230_passage",
"type": "progene_text",
"text": [
"A 38 - year - old woman with ulcerative colitis subsequently developed sarcoidosis ."
],
"offsets": [
[
0,
84
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29231
|
split_0_train_29231
|
[
{
"id": "split_0_train_29231_passage",
"type": "progene_text",
"text": [
"After ten years of recurrent episodes of colitis , she had presented with respiratory symptoms ."
],
"offsets": [
[
0,
96
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29232
|
split_0_train_29232
|
[
{
"id": "split_0_train_29232_passage",
"type": "progene_text",
"text": [
"The diagnosis of sarcoidosis was confirmed by mediastinal lymph node biopsy ."
],
"offsets": [
[
0,
77
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29233
|
split_0_train_29233
|
[
{
"id": "split_0_train_29233_passage",
"type": "progene_text",
"text": [
"Her respiratory symptoms gradually resolved without any specific treatment ."
],
"offsets": [
[
0,
76
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29234
|
split_0_train_29234
|
[
{
"id": "split_0_train_29234_passage",
"type": "progene_text",
"text": [
"Within the remission period of sarcoidosis , she underwent uneventful subtotal colectomy due to refractory colitis ."
],
"offsets": [
[
0,
116
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29235
|
split_0_train_29235
|
[
{
"id": "split_0_train_29235_passage",
"type": "progene_text",
"text": [
"Alterations in immune function and genetic susceptibility have been suggested to be present in both ulcerative colitis and sarcoidosis ."
],
"offsets": [
[
0,
136
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29236
|
split_0_train_29236
|
[
{
"id": "split_0_train_29236_passage",
"type": "progene_text",
"text": [
"However , the occurrence of both in the same patient has been rare ."
],
"offsets": [
[
0,
68
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29237
|
split_0_train_29237
|
[
{
"id": "split_0_train_29237_passage",
"type": "progene_text",
"text": [
"This is only the nineteenth case reported in the literature ."
],
"offsets": [
[
0,
61
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29238
|
split_0_train_29238
|
[
{
"id": "split_0_train_29238_passage",
"type": "progene_text",
"text": [
"Dietary boron supplementation enhanced the action of estrogen , but not that of parathyroid hormone , to improve trabecular bone quality in ovariectomized rats ."
],
"offsets": [
[
0,
161
]
]
}
] |
[
{
"id": "split_0_train_47474_entity",
"type": "progene_text",
"text": [
"parathyroid hormone"
],
"offsets": [
[
80,
99
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29239
|
split_0_train_29239
|
[
{
"id": "split_0_train_29239_passage",
"type": "progene_text",
"text": [
"This study investigated whether boron would enhance the ability of 17beta-estradiol ( E2 ) or parathyroid hormone ( PTH ) to improve bone quality in ovariectomized OVX rats ."
],
"offsets": [
[
0,
174
]
]
}
] |
[
{
"id": "split_0_train_47475_entity",
"type": "progene_text",
"text": [
"parathyroid hormone"
],
"offsets": [
[
94,
113
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],
"normalized": []
},
{
"id": "split_0_train_47476_entity",
"type": "progene_text",
"text": [
"PTH"
],
"offsets": [
[
116,
119
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29240
|
split_0_train_29240
|
[
{
"id": "split_0_train_29240_passage",
"type": "progene_text",
"text": [
"Adult OVX rats were treated for 5 wk with vehicle , boron ( 5 ppm as boric acid ) , E2 ( 30 microg / kg / d , sc ) , PTH ( 60 microg / kg / d , sc ) , or a combination of boron and E2 or PTH , respectively ."
],
"offsets": [
[
0,
207
]
]
}
] |
[
{
"id": "split_0_train_47477_entity",
"type": "progene_text",
"text": [
"PTH"
],
"offsets": [
[
187,
190
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29241
|
split_0_train_29241
|
[
{
"id": "split_0_train_29241_passage",
"type": "progene_text",
"text": [
"The E2 treatment corrected many adverse effects of OVX on bone quality , increased bone Ca , P , and Mg contents , and decreased trabecular plate separation ."
],
"offsets": [
[
0,
158
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29242
|
split_0_train_29242
|
[
{
"id": "split_0_train_29242_passage",
"type": "progene_text",
"text": [
"Dietary boron supplementation had no effects on these bone parameters in OVX rats ."
],
"offsets": [
[
0,
83
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29243
|
split_0_train_29243
|
[
{
"id": "split_0_train_29243_passage",
"type": "progene_text",
"text": [
"When OVX rats were treated with boron and E2 together , trabecular bone volume ( Tb.BS / TV ) and plate density were increased significantly more than that caused by E2 alone ."
],
"offsets": [
[
0,
176
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29244
|
split_0_train_29244
|
[
{
"id": "split_0_train_29244_passage",
"type": "progene_text",
"text": [
"The boron and E2 combination also increased trabecular bone surface ( Tb.BV / TV ) and decreased trabecular plate separation in OVX rats ."
],
"offsets": [
[
0,
138
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29245
|
split_0_train_29245
|
[
{
"id": "split_0_train_29245_passage",
"type": "progene_text",
"text": [
"In contrast , whereas daily PTH injection also increased bone Ca , Mg , and P contents , Tb.BV / TV , Tb.BS / TV , trabecular plate density and thickness , and decreased trabecular plate separation in OVX rats , the combination of boron and PTH had no additional improvement in bone quality over that achieved by PTH alone ."
],
"offsets": [
[
0,
324
]
]
}
] |
[
{
"id": "split_0_train_47478_entity",
"type": "progene_text",
"text": [
"PTH"
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28,
31
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{
"id": "split_0_train_47479_entity",
"type": "progene_text",
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"PTH"
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241,
244
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{
"id": "split_0_train_47480_entity",
"type": "progene_text",
"text": [
"PTH"
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"offsets": [
[
313,
316
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"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29246
|
split_0_train_29246
|
[
{
"id": "split_0_train_29246_passage",
"type": "progene_text",
"text": [
"In summary , this study shows for the first time that boron enhanced the action of E2 , but not that of PTH , to improve trabecular bone quality in OVX rats ."
],
"offsets": [
[
0,
158
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]
}
] |
[
{
"id": "split_0_train_47481_entity",
"type": "progene_text",
"text": [
"PTH"
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"offsets": [
[
104,
107
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29247
|
split_0_train_29247
|
[
{
"id": "split_0_train_29247_passage",
"type": "progene_text",
"text": [
"Psoriasis of the scalp ."
],
"offsets": [
[
0,
24
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29248
|
split_0_train_29248
|
[
{
"id": "split_0_train_29248_passage",
"type": "progene_text",
"text": [
"Diagnosis and management ."
],
"offsets": [
[
0,
26
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29249
|
split_0_train_29249
|
[
{
"id": "split_0_train_29249_passage",
"type": "progene_text",
"text": [
"Psoriasis of the scalp is a frequently occurring condition affecting approximately 2 % of the Western population ."
],
"offsets": [
[
0,
114
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29250
|
split_0_train_29250
|
[
{
"id": "split_0_train_29250_passage",
"type": "progene_text",
"text": [
"The sharply demarcated erythematosquamous lesions with silver - white scaling characterize scalp psoriasis ."
],
"offsets": [
[
0,
108
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29251
|
split_0_train_29251
|
[
{
"id": "split_0_train_29251_passage",
"type": "progene_text",
"text": [
"Quality of life can be seriously reduced by this condition and therefore long term treatment is needed in most patients ."
],
"offsets": [
[
0,
121
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29252
|
split_0_train_29252
|
[
{
"id": "split_0_train_29252_passage",
"type": "progene_text",
"text": [
"Coal tar shampoos , containing 2 to 10 % coal tar solution , are effective in scalp psoriasis ."
],
"offsets": [
[
0,
95
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29253
|
split_0_train_29253
|
[
{
"id": "split_0_train_29253_passage",
"type": "progene_text",
"text": [
"However , no double - blind studies are available to support such an assumption ."
],
"offsets": [
[
0,
81
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29254
|
split_0_train_29254
|
[
{
"id": "split_0_train_29254_passage",
"type": "progene_text",
"text": [
"Salicylic acid 5 to 10 % has a pronounced keratolytic effect ."
],
"offsets": [
[
0,
62
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29255
|
split_0_train_29255
|
[
{
"id": "split_0_train_29255_passage",
"type": "progene_text",
"text": [
"Salicylic acid should be formulated in an ointment , which can be washed off easily ."
],
"offsets": [
[
0,
85
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29256
|
split_0_train_29256
|
[
{
"id": "split_0_train_29256_passage",
"type": "progene_text",
"text": [
"Crude coal tar is the most effective tar available for the treatment of psoriasis ."
],
"offsets": [
[
0,
83
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29257
|
split_0_train_29257
|
[
{
"id": "split_0_train_29257_passage",
"type": "progene_text",
"text": [
"An important feature of coal tar is its potent efficacy against pruritus ."
],
"offsets": [
[
0,
74
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29258
|
split_0_train_29258
|
[
{
"id": "split_0_train_29258_passage",
"type": "progene_text",
"text": [
"At the scalp , the application of crude coal tar is difficult ."
],
"offsets": [
[
0,
63
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29259
|
split_0_train_29259
|
[
{
"id": "split_0_train_29259_passage",
"type": "progene_text",
"text": [
"Therefore coal tar solution is the most frequently applied tar preparation in scalp psoriasis ."
],
"offsets": [
[
0,
95
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29260
|
split_0_train_29260
|
[
{
"id": "split_0_train_29260_passage",
"type": "progene_text",
"text": [
"Dithranol 0.1 to 3 % is manufactured in various formulations ."
],
"offsets": [
[
0,
62
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29261
|
split_0_train_29261
|
[
{
"id": "split_0_train_29261_passage",
"type": "progene_text",
"text": [
"Treatment is initiated at a low concentration and the concentration is increased stepwise until a slight irritation , the feeling of warmth , is reached ."
],
"offsets": [
[
0,
154
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29262
|
split_0_train_29262
|
[
{
"id": "split_0_train_29262_passage",
"type": "progene_text",
"text": [
"In the treatment of scalp psoriasis , cream formulations are used ."
],
"offsets": [
[
0,
67
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29263
|
split_0_train_29263
|
[
{
"id": "split_0_train_29263_passage",
"type": "progene_text",
"text": [
"Imidazole antifungals have been used with success in scalp psoriasis ."
],
"offsets": [
[
0,
70
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29264
|
split_0_train_29264
|
[
{
"id": "split_0_train_29264_passage",
"type": "progene_text",
"text": [
"Overgrowth of the scalp with pityrosporon is a well - known feature of scalp psoriasis and seborrheic dermatitis ."
],
"offsets": [
[
0,
114
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29265
|
split_0_train_29265
|
[
{
"id": "split_0_train_29265_passage",
"type": "progene_text",
"text": [
"In case of resistance to other topical treatments use of a topical or systemic imidazole derivative might be helpful ."
],
"offsets": [
[
0,
118
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29266
|
split_0_train_29266
|
[
{
"id": "split_0_train_29266_passage",
"type": "progene_text",
"text": [
"So far , topical corticosteroids are the most frequently used treatments for psoriasis of the scalp ."
],
"offsets": [
[
0,
101
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29267
|
split_0_train_29267
|
[
{
"id": "split_0_train_29267_passage",
"type": "progene_text",
"text": [
"Corticosteroids inhibit epidermal proliferation , inhibit inflammation and modulate immune functions ."
],
"offsets": [
[
0,
102
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29268
|
split_0_train_29268
|
[
{
"id": "split_0_train_29268_passage",
"type": "progene_text",
"text": [
"Topical corticosteroids are fast acting : within 3 to 4 weeks maximal efficacy is reached ."
],
"offsets": [
[
0,
91
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29269
|
split_0_train_29269
|
[
{
"id": "split_0_train_29269_passage",
"type": "progene_text",
"text": [
"No data are available to support the efficacy and safety of topical corticosteroids during long term use ."
],
"offsets": [
[
0,
106
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29270
|
split_0_train_29270
|
[
{
"id": "split_0_train_29270_passage",
"type": "progene_text",
"text": [
"However , from epidemiologic surveys we know that these treatments are used by the majority of patients for more than 8 weeks ."
],
"offsets": [
[
0,
127
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29271
|
split_0_train_29271
|
[
{
"id": "split_0_train_29271_passage",
"type": "progene_text",
"text": [
"Since 1992 vitamin D3 formulations have been developed for the treatment of psoriasis ."
],
"offsets": [
[
0,
87
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29272
|
split_0_train_29272
|
[
{
"id": "split_0_train_29272_passage",
"type": "progene_text",
"text": [
"Calcipotriol is available in most countries ."
],
"offsets": [
[
0,
45
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29273
|
split_0_train_29273
|
[
{
"id": "split_0_train_29273_passage",
"type": "progene_text",
"text": [
"Tacalcitol is available in Japan and several other countries ."
],
"offsets": [
[
0,
62
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29274
|
split_0_train_29274
|
[
{
"id": "split_0_train_29274_passage",
"type": "progene_text",
"text": [
"Vitamin D3 analogues inhibit epidermal proliferation , enhance cornification and inhibit inflammation ."
],
"offsets": [
[
0,
103
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29275
|
split_0_train_29275
|
[
{
"id": "split_0_train_29275_passage",
"type": "progene_text",
"text": [
"Therefore , vitamin D3 analogues have a substantial antipsoriatic effect ."
],
"offsets": [
[
0,
74
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29276
|
split_0_train_29276
|
[
{
"id": "split_0_train_29276_passage",
"type": "progene_text",
"text": [
"Systemic treatments such as methotrexate , cyclosporine and acitretin are indicated in patients with recalcitrant disease ."
],
"offsets": [
[
0,
123
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29277
|
split_0_train_29277
|
[
{
"id": "split_0_train_29277_passage",
"type": "progene_text",
"text": [
"Management of scalp psoriasis requires long term strategies in order to reach an optimal improvement of the condition , while avoiding the adverse effects associated with the long term use of treatments ."
],
"offsets": [
[
0,
204
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29278
|
split_0_train_29278
|
[
{
"id": "split_0_train_29278_passage",
"type": "progene_text",
"text": [
"Phase II trial of the anti - G(D2) monoclonal antibody 3F8 and granulocyte - macrophage colony - stimulating factor for neuroblastoma ."
],
"offsets": [
[
0,
135
]
]
}
] |
[
{
"id": "split_0_train_47482_entity",
"type": "progene_text",
"text": [
"granulocyte - macrophage colony - stimulating factor"
],
"offsets": [
[
63,
115
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29279
|
split_0_train_29279
|
[
{
"id": "split_0_train_29279_passage",
"type": "progene_text",
"text": [
"PURPOSE :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29280
|
split_0_train_29280
|
[
{
"id": "split_0_train_29280_passage",
"type": "progene_text",
"text": [
"To describe oncolytic effects of treatment with anti - G(D2) monoclonal antibody 3F8 plus granulocyte - macrophage colony - stimulating factor ( GM-CSF ) in patients with neuroblastoma ( NB ) ."
],
"offsets": [
[
0,
193
]
]
}
] |
[
{
"id": "split_0_train_47483_entity",
"type": "progene_text",
"text": [
"granulocyte - macrophage colony - stimulating factor"
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"offsets": [
[
90,
142
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],
"normalized": []
},
{
"id": "split_0_train_47484_entity",
"type": "progene_text",
"text": [
"GM-CSF"
],
"offsets": [
[
145,
151
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29281
|
split_0_train_29281
|
[
{
"id": "split_0_train_29281_passage",
"type": "progene_text",
"text": [
"PATIENTS AND METHODS :"
],
"offsets": [
[
0,
22
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29282
|
split_0_train_29282
|
[
{
"id": "split_0_train_29282_passage",
"type": "progene_text",
"text": [
"Patients were eligible for 3F8 / GM-CSF if intensive therapy had not eradicated potentially lethal NB ."
],
"offsets": [
[
0,
103
]
]
}
] |
[
{
"id": "split_0_train_47485_entity",
"type": "progene_text",
"text": [
"GM-CSF"
],
"offsets": [
[
33,
39
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29283
|
split_0_train_29283
|
[
{
"id": "split_0_train_29283_passage",
"type": "progene_text",
"text": [
"One cycle consisted of GM-CSF ( subcutaneous bolus ) on days 1 through 5 , 11 , and 12 , and GM-CSF ( 2 - hour intravenous [ IV ] infusion ) followed after a 1 - hour interval by 3F8 ( 1.5 - hour IV infusion ) on days 6 through 10 and 13 through 17 ."
],
"offsets": [
[
0,
250
]
]
}
] |
[
{
"id": "split_0_train_47486_entity",
"type": "progene_text",
"text": [
"GM-CSF"
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"offsets": [
[
23,
29
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],
"normalized": []
},
{
"id": "split_0_train_47487_entity",
"type": "progene_text",
"text": [
"GM-CSF"
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"offsets": [
[
93,
99
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29284
|
split_0_train_29284
|
[
{
"id": "split_0_train_29284_passage",
"type": "progene_text",
"text": [
"GM-CSF was dosed at 250 microg / m(2) / d on days 1 through 7 and at 500 microg / m(2) / d on days 8 through 17 ."
],
"offsets": [
[
0,
113
]
]
}
] |
[
{
"id": "split_0_train_47488_entity",
"type": "progene_text",
"text": [
"GM-CSF"
],
"offsets": [
[
0,
6
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29285
|
split_0_train_29285
|
[
{
"id": "split_0_train_29285_passage",
"type": "progene_text",
"text": [
"3F8 was dosed at 10 mg / m(2) / d ( 100 mg / m(2) / cycle ) ."
],
"offsets": [
[
0,
61
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29286
|
split_0_train_29286
|
[
{
"id": "split_0_train_29286_passage",
"type": "progene_text",
"text": [
"3F8 was given with an opiate and an antihistamine ."
],
"offsets": [
[
0,
51
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29287
|
split_0_train_29287
|
[
{
"id": "split_0_train_29287_passage",
"type": "progene_text",
"text": [
"Patients without progressive disease ( PD ) or elevated human antimouse antibody titers could be treated again beginning 3 weeks after completion of a cycle ."
],
"offsets": [
[
0,
158
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29288
|
split_0_train_29288
|
[
{
"id": "split_0_train_29288_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29289
|
split_0_train_29289
|
[
{
"id": "split_0_train_29289_passage",
"type": "progene_text",
"text": [
"Among 19 patients treated for NB resistant to induction therapy , 12 of 15 had complete remission ( CR ) of bone marrow ( BM ) disease , and three others who had less than partial responses achieved prolonged progression - free survival ( one remains on study at 21 + months , two had PD at 12 and 17 months ) ."
],
"offsets": [
[
0,
311
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29290
|
split_0_train_29290
|
[
{
"id": "split_0_train_29290_passage",
"type": "progene_text",
"text": [
"Among patients treated for recurrent NB resistant to retrieval therapy , five of 10 had CR in BM ."
],
"offsets": [
[
0,
98
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29291
|
split_0_train_29291
|
[
{
"id": "split_0_train_29291_passage",
"type": "progene_text",
"text": [
"The 15 patients treated for PD fared poorly , although two had scintigraphic findings suggestive of a short - term response ."
],
"offsets": [
[
0,
125
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29292
|
split_0_train_29292
|
[
{
"id": "split_0_train_29292_passage",
"type": "progene_text",
"text": [
"Side effects were limited to readily manageable pain and , less commonly , rash of short duration ; hence , patients were treated as outpatients ."
],
"offsets": [
[
0,
146
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29293
|
split_0_train_29293
|
[
{
"id": "split_0_train_29293_passage",
"type": "progene_text",
"text": [
"CONCLUSION :"
],
"offsets": [
[
0,
12
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29294
|
split_0_train_29294
|
[
{
"id": "split_0_train_29294_passage",
"type": "progene_text",
"text": [
"3F8 / GM-CSF is well tolerated and shows promise for treatment of minimal residual NB in BM ."
],
"offsets": [
[
0,
93
]
]
}
] |
[
{
"id": "split_0_train_47489_entity",
"type": "progene_text",
"text": [
"GM-CSF"
],
"offsets": [
[
6,
12
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_29295
|
split_0_train_29295
|
[
{
"id": "split_0_train_29295_passage",
"type": "progene_text",
"text": [
"Oculomotor function in the rhesus monkey after deafferentation of the extraocular muscles ."
],
"offsets": [
[
0,
91
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29296
|
split_0_train_29296
|
[
{
"id": "split_0_train_29296_passage",
"type": "progene_text",
"text": [
"The function of extraocular muscle proprioception in the control of eye movements remains uncertain ."
],
"offsets": [
[
0,
101
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29297
|
split_0_train_29297
|
[
{
"id": "split_0_train_29297_passage",
"type": "progene_text",
"text": [
"In this study , we examined the effect of bilateral proprioceptive deafferentation of the extraocular muscles on eye movements in two rhesus monkeys ."
],
"offsets": [
[
0,
150
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29298
|
split_0_train_29298
|
[
{
"id": "split_0_train_29298_passage",
"type": "progene_text",
"text": [
"Before and after deafferentation , we analyzed baseline ocular alignment , saccades , pursuit , and vestibular eye movements ."
],
"offsets": [
[
0,
126
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_29299
|
split_0_train_29299
|
[
{
"id": "split_0_train_29299_passage",
"type": "progene_text",
"text": [
"We also examined visually mediated adaptation of ocular alignment , saccades , and pursuit ."
],
"offsets": [
[
0,
92
]
]
}
] |
[] |
[] |
[] |
[] |
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