id
stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
split_0_train_28900
|
split_0_train_28900
|
[
{
"id": "split_0_train_28900_passage",
"type": "progene_text",
"text": [
"To study the functional significance of the interaction , we expressed the Xenopus homologs of EED and YY1 in Xenopus embryos ."
],
"offsets": [
[
0,
127
]
]
}
] |
[
{
"id": "split_0_train_46929_entity",
"type": "progene_text",
"text": [
"EED"
],
"offsets": [
[
95,
98
]
],
"normalized": []
},
{
"id": "split_0_train_46930_entity",
"type": "progene_text",
"text": [
"YY1"
],
"offsets": [
[
103,
106
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28901
|
split_0_train_28901
|
[
{
"id": "split_0_train_28901_passage",
"type": "progene_text",
"text": [
"Both Xeed and XYY1 induce an ectopic neural axis but do not induce mesodermal tissues ."
],
"offsets": [
[
0,
87
]
]
}
] |
[
{
"id": "split_0_train_46931_entity",
"type": "progene_text",
"text": [
"Xeed"
],
"offsets": [
[
5,
9
]
],
"normalized": []
},
{
"id": "split_0_train_46932_entity",
"type": "progene_text",
"text": [
"XYY1"
],
"offsets": [
[
14,
18
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28902
|
split_0_train_28902
|
[
{
"id": "split_0_train_28902_passage",
"type": "progene_text",
"text": [
"In contrast , members of the HPC-HPH PcG complex do not induce neural tissue ."
],
"offsets": [
[
0,
78
]
]
}
] |
[
{
"id": "split_0_train_46933_entity",
"type": "progene_text",
"text": [
"HPC-HPH PcG complex"
],
"offsets": [
[
29,
48
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28903
|
split_0_train_28903
|
[
{
"id": "split_0_train_28903_passage",
"type": "progene_text",
"text": [
"The exclusive , direct neuralizing activity of both the Xeed and XYY1 proteins underlines the significance of the interaction between the two proteins ."
],
"offsets": [
[
0,
152
]
]
}
] |
[
{
"id": "split_0_train_46934_entity",
"type": "progene_text",
"text": [
"Xeed"
],
"offsets": [
[
56,
60
]
],
"normalized": []
},
{
"id": "split_0_train_46935_entity",
"type": "progene_text",
"text": [
"XYY1"
],
"offsets": [
[
65,
69
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28904
|
split_0_train_28904
|
[
{
"id": "split_0_train_28904_passage",
"type": "progene_text",
"text": [
"Our data also indicate a role for chromatin - associated proteins , such as PcG proteins , in Xenopus neural induction ."
],
"offsets": [
[
0,
120
]
]
}
] |
[
{
"id": "split_0_train_46936_entity",
"type": "progene_text",
"text": [
"PcG proteins"
],
"offsets": [
[
76,
88
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28905
|
split_0_train_28905
|
[
{
"id": "split_0_train_28905_passage",
"type": "progene_text",
"text": [
"The proteasome inhibitor MG132 promotes accumulation of the steroidogenic acute regulatory protein ( StAR ) and steroidogenesis ."
],
"offsets": [
[
0,
129
]
]
}
] |
[
{
"id": "split_0_train_46937_entity",
"type": "progene_text",
"text": [
"steroidogenic acute regulatory protein"
],
"offsets": [
[
60,
98
]
],
"normalized": []
},
{
"id": "split_0_train_46938_entity",
"type": "progene_text",
"text": [
"StAR"
],
"offsets": [
[
101,
105
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28906
|
split_0_train_28906
|
[
{
"id": "split_0_train_28906_passage",
"type": "progene_text",
"text": [
"StAR , a protein synthesized in the cytoplasm and subsequently imported into mitochondria , regulates the rate - determining step in steroidogenesis , the transport of cholesterol from the outer to the inner mitochondrial membrane ."
],
"offsets": [
[
0,
232
]
]
}
] |
[
{
"id": "split_0_train_46939_entity",
"type": "progene_text",
"text": [
"StAR"
],
"offsets": [
[
0,
4
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28907
|
split_0_train_28907
|
[
{
"id": "split_0_train_28907_passage",
"type": "progene_text",
"text": [
"The active form of StAR is the 37 kDa pre - protein , which has a short half - life ."
],
"offsets": [
[
0,
85
]
]
}
] |
[
{
"id": "split_0_train_46940_entity",
"type": "progene_text",
"text": [
"StAR"
],
"offsets": [
[
19,
23
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28908
|
split_0_train_28908
|
[
{
"id": "split_0_train_28908_passage",
"type": "progene_text",
"text": [
"To determine whether proteasomes participate in the turnover of StAR , we incubated primary cultures of preovulatory rat granulosa cells and immortalized human granulosa cells in the presence of MG132 , a specific inhibitor to proteasome catalysis ."
],
"offsets": [
[
0,
249
]
]
}
] |
[
{
"id": "split_0_train_46941_entity",
"type": "progene_text",
"text": [
"StAR"
],
"offsets": [
[
64,
68
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28909
|
split_0_train_28909
|
[
{
"id": "split_0_train_28909_passage",
"type": "progene_text",
"text": [
"This treatment caused accumulation of StAR in unstimulated cells ."
],
"offsets": [
[
0,
66
]
]
}
] |
[
{
"id": "split_0_train_46942_entity",
"type": "progene_text",
"text": [
"StAR"
],
"offsets": [
[
38,
42
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28910
|
split_0_train_28910
|
[
{
"id": "split_0_train_28910_passage",
"type": "progene_text",
"text": [
"Moreover , incubation of the cells with MG132 in the presence of forskolin ( FK ) , luteinizing hormone / chorionic gonadotropin or follicular stimulating hormone augmented the accumulation of both the 37 kDa cytoplasmic protein and the 30 kDa mature mitochondrial protein , compared to cells incubated with FK or the gonadotropic hormones alone ."
],
"offsets": [
[
0,
347
]
]
}
] |
[
{
"id": "split_0_train_46943_entity",
"type": "progene_text",
"text": [
"luteinizing hormone"
],
"offsets": [
[
84,
103
]
],
"normalized": []
},
{
"id": "split_0_train_46944_entity",
"type": "progene_text",
"text": [
"chorionic gonadotropin"
],
"offsets": [
[
106,
128
]
],
"normalized": []
},
{
"id": "split_0_train_46945_entity",
"type": "progene_text",
"text": [
"follicular stimulating hormone"
],
"offsets": [
[
132,
162
]
],
"normalized": []
},
{
"id": "split_0_train_46946_entity",
"type": "progene_text",
"text": [
"gonadotropic hormones"
],
"offsets": [
[
318,
339
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28911
|
split_0_train_28911
|
[
{
"id": "split_0_train_28911_passage",
"type": "progene_text",
"text": [
"Concomitantly , progesterone production was enhanced ."
],
"offsets": [
[
0,
54
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28912
|
split_0_train_28912
|
[
{
"id": "split_0_train_28912_passage",
"type": "progene_text",
"text": [
"In contrast no elevation in the 37 kDa StAR intracellular levels or progesterone production was observed following incubation of the cells with the cysteine protease inhibitor E-64 ."
],
"offsets": [
[
0,
182
]
]
}
] |
[
{
"id": "split_0_train_46947_entity",
"type": "progene_text",
"text": [
"StAR"
],
"offsets": [
[
39,
43
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28913
|
split_0_train_28913
|
[
{
"id": "split_0_train_28913_passage",
"type": "progene_text",
"text": [
"The increase of the 37 kDa StAR protein was evident after 15 min and 30 min of incubation with MG132 ( 143 % and 187 % of control values , respectively ) with no significant elevation of the 30 kDa protein ."
],
"offsets": [
[
0,
207
]
]
}
] |
[
{
"id": "split_0_train_46948_entity",
"type": "progene_text",
"text": [
"StAR"
],
"offsets": [
[
27,
31
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28914
|
split_0_train_28914
|
[
{
"id": "split_0_train_28914_passage",
"type": "progene_text",
"text": [
"Accumulation of the intermediate mitochondrial 32 kDa protein was evident after 1 - 2 h and the accumulation of the 30 kDa protein was evident only after 4 h of incubation with MG132 ."
],
"offsets": [
[
0,
184
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28915
|
split_0_train_28915
|
[
{
"id": "split_0_train_28915_passage",
"type": "progene_text",
"text": [
"In contrast , no elevation in adrenodoxin , a component of the cytochrome P450scc enzyme system , was found ."
],
"offsets": [
[
0,
109
]
]
}
] |
[
{
"id": "split_0_train_46949_entity",
"type": "progene_text",
"text": [
"cytochrome P450scc"
],
"offsets": [
[
63,
81
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28916
|
split_0_train_28916
|
[
{
"id": "split_0_train_28916_passage",
"type": "progene_text",
"text": [
"These data suggest that StAR protein is either directly or indirectly degraded by the proteasome which may explain , in part , its short half - life ."
],
"offsets": [
[
0,
150
]
]
}
] |
[
{
"id": "split_0_train_46950_entity",
"type": "progene_text",
"text": [
"StAR"
],
"offsets": [
[
24,
28
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28917
|
split_0_train_28917
|
[
{
"id": "split_0_train_28917_passage",
"type": "progene_text",
"text": [
"Moreover , it seems that the cytosolic 37 kDa protein , which is responsible for the steroidogenic activity of StAR , is the primary proteasomal substrate and that the inhibition of its degradation by MG132 causes the up - regulation of progesterone production ."
],
"offsets": [
[
0,
262
]
]
}
] |
[
{
"id": "split_0_train_46951_entity",
"type": "progene_text",
"text": [
"StAR"
],
"offsets": [
[
111,
115
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28918
|
split_0_train_28918
|
[
{
"id": "split_0_train_28918_passage",
"type": "progene_text",
"text": [
"Apolipoprotein E and Alzheimer 's disease ."
],
"offsets": [
[
0,
43
]
]
}
] |
[
{
"id": "split_0_train_46952_entity",
"type": "progene_text",
"text": [
"Apolipoprotein E"
],
"offsets": [
[
0,
16
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28919
|
split_0_train_28919
|
[
{
"id": "split_0_train_28919_passage",
"type": "progene_text",
"text": [
"A role in amyloid catabolism ."
],
"offsets": [
[
0,
30
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28920
|
split_0_train_28920
|
[
{
"id": "split_0_train_28920_passage",
"type": "progene_text",
"text": [
"It has been shown over the past few years that apolipoprotein E ( apoE ) plays a central role in the brain response to injury and neurodegeneration in mammalian species ."
],
"offsets": [
[
0,
170
]
]
}
] |
[
{
"id": "split_0_train_46953_entity",
"type": "progene_text",
"text": [
"apolipoprotein E"
],
"offsets": [
[
47,
63
]
],
"normalized": []
},
{
"id": "split_0_train_46954_entity",
"type": "progene_text",
"text": [
"apoE"
],
"offsets": [
[
66,
70
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28921
|
split_0_train_28921
|
[
{
"id": "split_0_train_28921_passage",
"type": "progene_text",
"text": [
"The coordinated expression of apoE and its different receptors , the so - called LDL receptor family , appears to regulate the transport of cholesterol and phospholipids during the early and middle phases of the reinnervation in the adult mammalian brain ."
],
"offsets": [
[
0,
256
]
]
}
] |
[
{
"id": "split_0_train_46955_entity",
"type": "progene_text",
"text": [
"apoE"
],
"offsets": [
[
30,
34
]
],
"normalized": []
},
{
"id": "split_0_train_46956_entity",
"type": "progene_text",
"text": [
"LDL receptor family"
],
"offsets": [
[
81,
100
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28922
|
split_0_train_28922
|
[
{
"id": "split_0_train_28922_passage",
"type": "progene_text",
"text": [
"As neurons undergo dendritic remodelling and synaptogenesis using cholesterol internalization through the apoE / LDL receptor pathway , they progressively shut down 3,3-hydroxymethylglutaryl-Coenzyme A ( HMG CoA ) reductase activity , the rate - limiting enzyme in the synthesis of cholesterol ."
],
"offsets": [
[
0,
295
]
]
}
] |
[
{
"id": "split_0_train_46957_entity",
"type": "progene_text",
"text": [
"apoE"
],
"offsets": [
[
106,
110
]
],
"normalized": []
},
{
"id": "split_0_train_46958_entity",
"type": "progene_text",
"text": [
"LDL receptor"
],
"offsets": [
[
113,
125
]
],
"normalized": []
},
{
"id": "split_0_train_46959_entity",
"type": "progene_text",
"text": [
"3,3-hydroxymethylglutaryl-Coenzyme A ( HMG CoA ) reductase"
],
"offsets": [
[
165,
223
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28923
|
split_0_train_28923
|
[
{
"id": "split_0_train_28923_passage",
"type": "progene_text",
"text": [
"These results suggest that cholesterol delivery and synthesis in the brain are tightly regulated through an apoE - dependent mechanism ."
],
"offsets": [
[
0,
136
]
]
}
] |
[
{
"id": "split_0_train_46960_entity",
"type": "progene_text",
"text": [
"apoE"
],
"offsets": [
[
108,
112
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28924
|
split_0_train_28924
|
[
{
"id": "split_0_train_28924_passage",
"type": "progene_text",
"text": [
"The discovery that the apolipoprotein e4 allele is strongly linked to both sporadic and familial late - onset Alzheimer 's disease ( AD ) has raised the possibility that a dysfunction of lipid transport could explain the poor compensatory synaptogenesis reported by several independent research groups in the brain of AD subjects ."
],
"offsets": [
[
0,
331
]
]
}
] |
[
{
"id": "split_0_train_46961_entity",
"type": "progene_text",
"text": [
"apolipoprotein e4"
],
"offsets": [
[
23,
40
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28925
|
split_0_train_28925
|
[
{
"id": "split_0_train_28925_passage",
"type": "progene_text",
"text": [
"Recently , it has been shown that alterations of cholesterol homeostasis in the brain by exogenous administration of dietary cholesterol , or through inhibition of cholesterol synthesis , markedly affect beta amyloid production ( 1 - 40 and 1-42 ) and deposition and significantly impair amyloid precursor protein ( APP ) metabolism ."
],
"offsets": [
[
0,
334
]
]
}
] |
[
{
"id": "split_0_train_46962_entity",
"type": "progene_text",
"text": [
"beta amyloid"
],
"offsets": [
[
204,
216
]
],
"normalized": []
},
{
"id": "split_0_train_46963_entity",
"type": "progene_text",
"text": [
"amyloid precursor protein"
],
"offsets": [
[
288,
313
]
],
"normalized": []
},
{
"id": "split_0_train_46964_entity",
"type": "progene_text",
"text": [
"APP"
],
"offsets": [
[
316,
319
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28926
|
split_0_train_28926
|
[
{
"id": "split_0_train_28926_passage",
"type": "progene_text",
"text": [
"In vivo , it has been shown that breeding of APP - overexpressing mice with apoE knockout mice completely abolishes amyloid plaque deposition in the brain of hybrid animals , without affecting beta amyloid steady state levels ."
],
"offsets": [
[
0,
227
]
]
}
] |
[
{
"id": "split_0_train_46965_entity",
"type": "progene_text",
"text": [
"APP"
],
"offsets": [
[
45,
48
]
],
"normalized": []
},
{
"id": "split_0_train_46966_entity",
"type": "progene_text",
"text": [
"apoE"
],
"offsets": [
[
76,
80
]
],
"normalized": []
},
{
"id": "split_0_train_46967_entity",
"type": "progene_text",
"text": [
"beta amyloid"
],
"offsets": [
[
193,
205
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28927
|
split_0_train_28927
|
[
{
"id": "split_0_train_28927_passage",
"type": "progene_text",
"text": [
"Conversely , introduction of the human apoE3 and apoE4 genes in APP - overexpressing mice drastically reduced beta amyloid deposition in the brain of hybrid mice , confirming the proposed biological role of apoE in the clearance of extracellular beta amyloid ."
],
"offsets": [
[
0,
260
]
]
}
] |
[
{
"id": "split_0_train_46968_entity",
"type": "progene_text",
"text": [
"apoE3"
],
"offsets": [
[
39,
44
]
],
"normalized": []
},
{
"id": "split_0_train_46969_entity",
"type": "progene_text",
"text": [
"apoE4"
],
"offsets": [
[
49,
54
]
],
"normalized": []
},
{
"id": "split_0_train_46970_entity",
"type": "progene_text",
"text": [
"APP"
],
"offsets": [
[
64,
67
]
],
"normalized": []
},
{
"id": "split_0_train_46971_entity",
"type": "progene_text",
"text": [
"beta amyloid"
],
"offsets": [
[
110,
122
]
],
"normalized": []
},
{
"id": "split_0_train_46972_entity",
"type": "progene_text",
"text": [
"apoE"
],
"offsets": [
[
207,
211
]
],
"normalized": []
},
{
"id": "split_0_train_46973_entity",
"type": "progene_text",
"text": [
"beta amyloid"
],
"offsets": [
[
246,
258
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28928
|
split_0_train_28928
|
[
{
"id": "split_0_train_28928_passage",
"type": "progene_text",
"text": [
"These results indicate that lipid homeostasis is controlled in large part by the apoE lipoprotein transport system in the extracellular space , whereas alterations in intracellular lipid homeostasis markedly affect APP processing , beta amyloid production and plaque formation in vivo ."
],
"offsets": [
[
0,
286
]
]
}
] |
[
{
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split_0_train_28929
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split_0_train_28929
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"The convergence of the so - called amyloid cascade hypothesis ( Hardy et al. , 1992 ) and of the apoE / lipid recycling cascade model ( Poirier , 1994 ) is consistent with the notion that alterations in lipid homeostasis could serve as the common denominator for apoE and beta amyloid dysfunctions in Alzheimer 's disease ."
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[] |
[] |
[] |
split_0_train_28930
|
split_0_train_28930
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split_0_train_28931
|
split_0_train_28931
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"This system is unique in the CNS since it relies heavily on lipid bioavailability to locally synthesize acetylcholine ."
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[] |
[] |
[] |
[] |
split_0_train_28932
|
split_0_train_28932
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"It is thus quite tempting to propose that two of the most common neuropathologic landmarks of AD -- namely , cholinergic dysfunction and amyloid deposition - - may in fact depend on the integrity of local lipid homeostatic processes , which in turn are strongly dependent upon proper lipid delivery by the apoE transport system ."
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[] |
split_0_train_28933
|
split_0_train_28933
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[] |
[] |
[] |
[] |
split_0_train_28934
|
split_0_train_28934
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"Tumor immunotherapy has been limited to date by the poor antigenicity of most tumors , the immunocompromised state of many cancer patients , and the slow tumor penetration and short half - life of exogenously - introduced anti - tumor antibodies ."
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[] |
[] |
split_0_train_28935
|
split_0_train_28935
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[] |
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[] |
[] |
split_0_train_28936
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split_0_train_28936
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[] |
[] |
[] |
[] |
split_0_train_28937
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split_0_train_28937
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[] |
split_0_train_28938
|
split_0_train_28938
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"As a model chimeric receptor gene we used a tripartite construct consisting of a single - chain anti - TNP antibody variable region linked to part of the extracellular domain and the membrane spanning regions of the CD28 coreceptor molecule and joined at its 5' end to a gene fragment encoding the intracellular moiety of the gamma activation molecule common to the Fcepsilon and Fcgamma receptors ."
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[] |
[] |
split_0_train_28939
|
split_0_train_28939
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[] |
[] |
[] |
split_0_train_28940
|
split_0_train_28940
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"In routine experiments , the transgene was expressed in 35 - 70 % of the human T cells ."
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[] |
[] |
[] |
[] |
split_0_train_28941
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split_0_train_28941
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"Such lymphocytes express the chimeric receptors on their surface and upon stimulation with hapten immobilized on plastic they can produce IL-2 ."
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[] |
[] |
split_0_train_28942
|
split_0_train_28942
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[] |
[] |
split_0_train_28943
|
split_0_train_28943
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{
"id": "split_0_train_28943_passage",
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"text": [
"Moreover , the transduced lymphocytes could effectively lyse target cells expressing the TNP hapten on their surface ."
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[] |
[] |
[] |
[] |
split_0_train_28944
|
split_0_train_28944
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"id": "split_0_train_28944_passage",
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"These studies establish the conditions for the optimal transfection of effector lymphocytes to redirect them against a variety of tumor targets ."
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[] |
[] |
[] |
[] |
split_0_train_28945
|
split_0_train_28945
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[] |
[] |
[] |
split_0_train_28946
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split_0_train_28946
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"Signals of interleukin 6 ( IL-6 ) are transduced by binding of IL-6 to its cell surface receptor ( IL-6R ) and subsequent association of the resultant IL-6 / IL-6R complex with gp130 , the signal transducing receptor component utilized in common by all the IL-6 family of cytokines ."
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[] |
[] |
split_0_train_28947
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split_0_train_28947
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"text": [
"A soluble form of IL-6R ( sIL-6R ) , which lacks transmembrane and cytoplasmic regions , retains the ability to bind IL-6 and signal through gp130 ."
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[] |
[] |
[] |
split_0_train_28948
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split_0_train_28948
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}
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[] |
[] |
[] |
split_0_train_28949
|
split_0_train_28949
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[
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"text": [
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}
] |
[] |
[] |
[] |
split_0_train_28950
|
split_0_train_28950
|
[
{
"id": "split_0_train_28950_passage",
"type": "progene_text",
"text": [
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}
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[
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98,
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}
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[] |
[] |
[] |
split_0_train_28951
|
split_0_train_28951
|
[
{
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"text": [
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"text": [
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184,
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}
] |
[] |
[] |
[] |
split_0_train_28952
|
split_0_train_28952
|
[
{
"id": "split_0_train_28952_passage",
"type": "progene_text",
"text": [
"These results suggest that FP6 induces astrocyte differentiation from neuroepithelial cells through STAT3 activation and that FP6 could be of use as a substitute for natural IL-6 family cytokines ."
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197
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}
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[
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"text": [
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174,
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}
] |
[] |
[] |
[] |
split_0_train_28953
|
split_0_train_28953
|
[
{
"id": "split_0_train_28953_passage",
"type": "progene_text",
"text": [
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107
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}
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[
{
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"type": "progene_text",
"text": [
"penton base"
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"offsets": [
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69,
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}
] |
[] |
[] |
[] |
split_0_train_28954
|
split_0_train_28954
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[
{
"id": "split_0_train_28954_passage",
"type": "progene_text",
"text": [
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0,
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] |
[
{
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"text": [
"integrin"
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[
59,
67
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}
] |
[] |
[] |
[] |
split_0_train_28955
|
split_0_train_28955
|
[
{
"id": "split_0_train_28955_passage",
"type": "progene_text",
"text": [
"We report that filamentous phage displaying either the full - length penton base gene or a central region of 107 amino acids on their surface were able to bind , internalise , and transduce mammalian cells expressing integrin receptors ."
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[
0,
237
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}
] |
[
{
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"type": "progene_text",
"text": [
"integrin"
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217,
225
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}
] |
[] |
[] |
[] |
split_0_train_28956
|
split_0_train_28956
|
[
{
"id": "split_0_train_28956_passage",
"type": "progene_text",
"text": [
"Both phage bound alphavbeta3 , alphavbeta5 , alpha3beta1 , and alpha5beta1 integrin subtypes ."
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[
0,
94
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]
}
] |
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{
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{
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45,
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{
"id": "split_0_train_47031_entity",
"type": "progene_text",
"text": [
"alpha5beta1 integrin"
],
"offsets": [
[
63,
83
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28957
|
split_0_train_28957
|
[
{
"id": "split_0_train_28957_passage",
"type": "progene_text",
"text": [
"Cell - binding was shown by electron microscopy ; internalisation was investigated by immunofluorescence and confirmed by micropanning ."
],
"offsets": [
[
0,
136
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28958
|
split_0_train_28958
|
[
{
"id": "split_0_train_28958_passage",
"type": "progene_text",
"text": [
"As it has been described for adenovirus , pharmacologic disruption of phosphoinositide - 30H kinase , but not of myosin light - chain kinase , inhibited phage internalisation ."
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0,
176
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]
}
] |
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{
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{
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"text": [
"myosin light - chain kinase"
],
"offsets": [
[
113,
140
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28959
|
split_0_train_28959
|
[
{
"id": "split_0_train_28959_passage",
"type": "progene_text",
"text": [
"Recombinant phage encoding an eukaryotic expression cassette was able to mediate gene expression in mammalian cells ."
],
"offsets": [
[
0,
117
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28960
|
split_0_train_28960
|
[
{
"id": "split_0_train_28960_passage",
"type": "progene_text",
"text": [
"Taken together , these data open insights for the exploit of recombinant phage for integrin - targeted gene delivery ."
],
"offsets": [
[
0,
118
]
]
}
] |
[
{
"id": "split_0_train_47034_entity",
"type": "progene_text",
"text": [
"integrin"
],
"offsets": [
[
83,
91
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28961
|
split_0_train_28961
|
[
{
"id": "split_0_train_28961_passage",
"type": "progene_text",
"text": [
"Gaf-1 , a gamma - SNAP - binding protein associated with the mitochondria ."
],
"offsets": [
[
0,
75
]
]
}
] |
[
{
"id": "split_0_train_47035_entity",
"type": "progene_text",
"text": [
"Gaf-1"
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0,
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{
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"type": "progene_text",
"text": [
"gamma - SNAP"
],
"offsets": [
[
10,
22
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28962
|
split_0_train_28962
|
[
{
"id": "split_0_train_28962_passage",
"type": "progene_text",
"text": [
"The role of alpha/beta-SNAP ( Soluble NSF Attachment Protein ) in vesicular trafficking is well established ; however , the function of the ubiquitously expressed gamma-SNAP remains unclear ."
],
"offsets": [
[
0,
191
]
]
}
] |
[
{
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12,
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},
{
"id": "split_0_train_47038_entity",
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30,
60
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{
"id": "split_0_train_47039_entity",
"type": "progene_text",
"text": [
"gamma-SNAP"
],
"offsets": [
[
163,
173
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28963
|
split_0_train_28963
|
[
{
"id": "split_0_train_28963_passage",
"type": "progene_text",
"text": [
"To further characterize the cellular role of this enigmatic protein , a two - hybrid screen was used to identify new , gamma-SNAP - binding proteins and to uncover potentially novel functions for gamma-SNAP ."
],
"offsets": [
[
0,
208
]
]
}
] |
[
{
"id": "split_0_train_47040_entity",
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119,
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{
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"type": "progene_text",
"text": [
"gamma-SNAP"
],
"offsets": [
[
196,
206
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28964
|
split_0_train_28964
|
[
{
"id": "split_0_train_28964_passage",
"type": "progene_text",
"text": [
"One such SNAP - binding protein , termed Gaf-1 ( gamma-SNAP associate factor-1) specifically binds gamma - but not alpha-SNAP ."
],
"offsets": [
[
0,
127
]
]
}
] |
[
{
"id": "split_0_train_47042_entity",
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"text": [
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9,
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{
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{
"id": "split_0_train_47044_entity",
"type": "progene_text",
"text": [
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[
49,
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],
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},
{
"id": "split_0_train_47045_entity",
"type": "progene_text",
"text": [
"gamma - but not alpha-SNAP"
],
"offsets": [
[
99,
125
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28965
|
split_0_train_28965
|
[
{
"id": "split_0_train_28965_passage",
"type": "progene_text",
"text": [
"The full - length Gaf-1 ( 75 kDa ) is ubiquitously expressed and is found stoichiometrically associated with gamma-SNAP in cellular extracts ."
],
"offsets": [
[
0,
142
]
]
}
] |
[
{
"id": "split_0_train_47046_entity",
"type": "progene_text",
"text": [
"Gaf-1"
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[
18,
23
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{
"id": "split_0_train_47047_entity",
"type": "progene_text",
"text": [
"gamma-SNAP"
],
"offsets": [
[
109,
119
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28966
|
split_0_train_28966
|
[
{
"id": "split_0_train_28966_passage",
"type": "progene_text",
"text": [
"This binding is distinct from other SNAP interactions since no alpha-SNAP or NSF coprecipitated with Gaf-1 ."
],
"offsets": [
[
0,
108
]
]
}
] |
[
{
"id": "split_0_train_47048_entity",
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36,
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{
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63,
73
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{
"id": "split_0_train_47050_entity",
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"text": [
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77,
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},
{
"id": "split_0_train_47051_entity",
"type": "progene_text",
"text": [
"Gaf-1"
],
"offsets": [
[
101,
106
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28967
|
split_0_train_28967
|
[
{
"id": "split_0_train_28967_passage",
"type": "progene_text",
"text": [
"Subcellular fractionation and immunofluorescence analysis show that Gaf-1 is peripherally associated with the outer mitochondrial membrane ."
],
"offsets": [
[
0,
140
]
]
}
] |
[
{
"id": "split_0_train_47052_entity",
"type": "progene_text",
"text": [
"Gaf-1"
],
"offsets": [
[
68,
73
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28968
|
split_0_train_28968
|
[
{
"id": "split_0_train_28968_passage",
"type": "progene_text",
"text": [
"Only a fraction of gamma-SNAP was mitochondrial with the balance being either cytosolic or associated with other membrane fractions ."
],
"offsets": [
[
0,
133
]
]
}
] |
[
{
"id": "split_0_train_47053_entity",
"type": "progene_text",
"text": [
"gamma-SNAP"
],
"offsets": [
[
19,
29
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28969
|
split_0_train_28969
|
[
{
"id": "split_0_train_28969_passage",
"type": "progene_text",
"text": [
"GFP - gamma-SNAP and the C - terminal domain of Gaf-1 both show a reticular distribution in HEK-293 cells ."
],
"offsets": [
[
0,
107
]
]
}
] |
[
{
"id": "split_0_train_47054_entity",
"type": "progene_text",
"text": [
"gamma-SNAP"
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[
6,
16
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{
"id": "split_0_train_47055_entity",
"type": "progene_text",
"text": [
"Gaf-1"
],
"offsets": [
[
48,
53
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28970
|
split_0_train_28970
|
[
{
"id": "split_0_train_28970_passage",
"type": "progene_text",
"text": [
"This reticular structure colocalizes with Gaf-1 and mitochondria as well as with microtubules but not with other cytoskeletal elements ."
],
"offsets": [
[
0,
136
]
]
}
] |
[
{
"id": "split_0_train_47056_entity",
"type": "progene_text",
"text": [
"Gaf-1"
],
"offsets": [
[
42,
47
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28971
|
split_0_train_28971
|
[
{
"id": "split_0_train_28971_passage",
"type": "progene_text",
"text": [
"These data identify a class of gamma-SNAP interactions that is distinct from other members of the SNAP family and point to a potential role for gamma-SNAP in mitochondrial dynamics ."
],
"offsets": [
[
0,
182
]
]
}
] |
[
{
"id": "split_0_train_47057_entity",
"type": "progene_text",
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31,
41
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},
{
"id": "split_0_train_47058_entity",
"type": "progene_text",
"text": [
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98,
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{
"id": "split_0_train_47059_entity",
"type": "progene_text",
"text": [
"gamma-SNAP"
],
"offsets": [
[
144,
154
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28972
|
split_0_train_28972
|
[
{
"id": "split_0_train_28972_passage",
"type": "progene_text",
"text": [
"The gene yghK linked to the glc operon of Escherichia coli encodes a permease for glycolate that is structurally and functionally similar to L-lactate permease ."
],
"offsets": [
[
0,
161
]
]
}
] |
[
{
"id": "split_0_train_47060_entity",
"type": "progene_text",
"text": [
"yghK"
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[
9,
13
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},
{
"id": "split_0_train_47061_entity",
"type": "progene_text",
"text": [
"glc operon"
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28,
38
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},
{
"id": "split_0_train_47062_entity",
"type": "progene_text",
"text": [
"L-lactate permease"
],
"offsets": [
[
141,
159
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28973
|
split_0_train_28973
|
[
{
"id": "split_0_train_28973_passage",
"type": "progene_text",
"text": [
"In Escherichia coli the glc operon involved in glycolate utilization is located at 67.3 min and formed by genes encoding the enzymes glycolate oxidase ( glcDEF ) and malate synthase G ( glcB ) ."
],
"offsets": [
[
0,
194
]
]
}
] |
[
{
"id": "split_0_train_47063_entity",
"type": "progene_text",
"text": [
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24,
34
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},
{
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133,
150
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{
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153,
159
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},
{
"id": "split_0_train_47066_entity",
"type": "progene_text",
"text": [
"malate synthase G"
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166,
183
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},
{
"id": "split_0_train_47067_entity",
"type": "progene_text",
"text": [
"glcB"
],
"offsets": [
[
186,
190
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28974
|
split_0_train_28974
|
[
{
"id": "split_0_train_28974_passage",
"type": "progene_text",
"text": [
"Their expression from a single promoter upstream of glcD is induced by growth on glycolate and regulated by the activator encoded by the divergently transcribed gene glcC ."
],
"offsets": [
[
0,
172
]
]
}
] |
[
{
"id": "split_0_train_47068_entity",
"type": "progene_text",
"text": [
"glcD"
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52,
56
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},
{
"id": "split_0_train_47069_entity",
"type": "progene_text",
"text": [
"glcC"
],
"offsets": [
[
166,
170
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28975
|
split_0_train_28975
|
[
{
"id": "split_0_train_28975_passage",
"type": "progene_text",
"text": [
"Gene yghK , located 350 bp downstream of glcB , encodes a hydrophobic protein highly similar to the L-lactate permease encoded by lldP ."
],
"offsets": [
[
0,
136
]
]
}
] |
[
{
"id": "split_0_train_47070_entity",
"type": "progene_text",
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[
5,
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},
{
"id": "split_0_train_47071_entity",
"type": "progene_text",
"text": [
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[
41,
45
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},
{
"id": "split_0_train_47072_entity",
"type": "progene_text",
"text": [
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"offsets": [
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100,
118
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},
{
"id": "split_0_train_47073_entity",
"type": "progene_text",
"text": [
"lldP"
],
"offsets": [
[
130,
134
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28976
|
split_0_train_28976
|
[
{
"id": "split_0_train_28976_passage",
"type": "progene_text",
"text": [
"Expression studies have shown that the yghK gene ( proposed name glcA ) is transcribed from the same promoter as the other glc structural genes and thus belongs to the glc operon ."
],
"offsets": [
[
0,
180
]
]
}
] |
[
{
"id": "split_0_train_47074_entity",
"type": "progene_text",
"text": [
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39,
43
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},
{
"id": "split_0_train_47075_entity",
"type": "progene_text",
"text": [
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"offsets": [
[
65,
69
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},
{
"id": "split_0_train_47076_entity",
"type": "progene_text",
"text": [
"glc"
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"offsets": [
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123,
126
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"normalized": []
},
{
"id": "split_0_train_47077_entity",
"type": "progene_text",
"text": [
"glc operon"
],
"offsets": [
[
168,
178
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28977
|
split_0_train_28977
|
[
{
"id": "split_0_train_28977_passage",
"type": "progene_text",
"text": [
"Characterization of a glcA : : cat mutant showed that GlcA acts as glycolate permease and that glycolate can also enter the cell through another transport system ."
],
"offsets": [
[
0,
163
]
]
}
] |
[
{
"id": "split_0_train_47078_entity",
"type": "progene_text",
"text": [
"glcA"
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"offsets": [
[
22,
26
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],
"normalized": []
},
{
"id": "split_0_train_47079_entity",
"type": "progene_text",
"text": [
"GlcA"
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"offsets": [
[
54,
58
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],
"normalized": []
},
{
"id": "split_0_train_47080_entity",
"type": "progene_text",
"text": [
"glycolate permease"
],
"offsets": [
[
67,
85
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28978
|
split_0_train_28978
|
[
{
"id": "split_0_train_28978_passage",
"type": "progene_text",
"text": [
"Evidence is presented of the involvement of L-lactate permease in glycolate uptake ."
],
"offsets": [
[
0,
84
]
]
}
] |
[
{
"id": "split_0_train_47081_entity",
"type": "progene_text",
"text": [
"L-lactate permease"
],
"offsets": [
[
44,
62
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28979
|
split_0_train_28979
|
[
{
"id": "split_0_train_28979_passage",
"type": "progene_text",
"text": [
"Growth on this compound was abolished in a double mutant of the paralogous genes glcA and lldP , and restored with plasmids expressing either GlcA or LldP ."
],
"offsets": [
[
0,
156
]
]
}
] |
[
{
"id": "split_0_train_47082_entity",
"type": "progene_text",
"text": [
"glcA"
],
"offsets": [
[
81,
85
]
],
"normalized": []
},
{
"id": "split_0_train_47083_entity",
"type": "progene_text",
"text": [
"lldP"
],
"offsets": [
[
90,
94
]
],
"normalized": []
},
{
"id": "split_0_train_47084_entity",
"type": "progene_text",
"text": [
"GlcA"
],
"offsets": [
[
142,
146
]
],
"normalized": []
},
{
"id": "split_0_train_47085_entity",
"type": "progene_text",
"text": [
"LldP"
],
"offsets": [
[
150,
154
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28980
|
split_0_train_28980
|
[
{
"id": "split_0_train_28980_passage",
"type": "progene_text",
"text": [
"Characterization of the putative substrates for these two related permeases showed , in both cases , specificity for the 2 - hydroxymonocarboxylates glycolate , L-lactate and D-lactate ."
],
"offsets": [
[
0,
186
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28981
|
split_0_train_28981
|
[
{
"id": "split_0_train_28981_passage",
"type": "progene_text",
"text": [
"Although both GlcA and LldP recognize D-lactate , mutant analysis proved that L-lactate permease is mainly responsible for its uptake ."
],
"offsets": [
[
0,
135
]
]
}
] |
[
{
"id": "split_0_train_47086_entity",
"type": "progene_text",
"text": [
"GlcA"
],
"offsets": [
[
14,
18
]
],
"normalized": []
},
{
"id": "split_0_train_47087_entity",
"type": "progene_text",
"text": [
"LldP"
],
"offsets": [
[
23,
27
]
],
"normalized": []
},
{
"id": "split_0_train_47088_entity",
"type": "progene_text",
"text": [
"L-lactate permease"
],
"offsets": [
[
78,
96
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28982
|
split_0_train_28982
|
[
{
"id": "split_0_train_28982_passage",
"type": "progene_text",
"text": [
"Platelet - derived growth factor C ( PDGF-C ) , a novel growth factor that binds to PDGF alpha and beta receptor ."
],
"offsets": [
[
0,
114
]
]
}
] |
[
{
"id": "split_0_train_47089_entity",
"type": "progene_text",
"text": [
"Platelet - derived growth factor C"
],
"offsets": [
[
0,
34
]
],
"normalized": []
},
{
"id": "split_0_train_47090_entity",
"type": "progene_text",
"text": [
"PDGF-C"
],
"offsets": [
[
37,
43
]
],
"normalized": []
},
{
"id": "split_0_train_47091_entity",
"type": "progene_text",
"text": [
"growth factor"
],
"offsets": [
[
56,
69
]
],
"normalized": []
},
{
"id": "split_0_train_47092_entity",
"type": "progene_text",
"text": [
"PDGF alpha and beta receptor"
],
"offsets": [
[
84,
112
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28983
|
split_0_train_28983
|
[
{
"id": "split_0_train_28983_passage",
"type": "progene_text",
"text": [
"We have characterized platelet - derived growth factor ( PDGF ) C , a novel growth factor belonging to the PDGF family ."
],
"offsets": [
[
0,
120
]
]
}
] |
[
{
"id": "split_0_train_47093_entity",
"type": "progene_text",
"text": [
"platelet - derived growth factor ( PDGF ) C"
],
"offsets": [
[
22,
65
]
],
"normalized": []
},
{
"id": "split_0_train_47094_entity",
"type": "progene_text",
"text": [
"growth factor"
],
"offsets": [
[
76,
89
]
],
"normalized": []
},
{
"id": "split_0_train_47095_entity",
"type": "progene_text",
"text": [
"PDGF family"
],
"offsets": [
[
107,
118
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28984
|
split_0_train_28984
|
[
{
"id": "split_0_train_28984_passage",
"type": "progene_text",
"text": [
"PDGF-C is a multidomain protein with the N - terminal region homologous to the extracellular CUB domain of neuropilin-1 , and the C - terminal region consists of a growth factor domain ( GFD ) with homology to vascular endothelial growth factor ( 25 % ) and PDGF A - chain ( 23 % ) ."
],
"offsets": [
[
0,
283
]
]
}
] |
[
{
"id": "split_0_train_47096_entity",
"type": "progene_text",
"text": [
"PDGF-C"
],
"offsets": [
[
0,
6
]
],
"normalized": []
},
{
"id": "split_0_train_47097_entity",
"type": "progene_text",
"text": [
"neuropilin-1"
],
"offsets": [
[
107,
119
]
],
"normalized": []
},
{
"id": "split_0_train_47098_entity",
"type": "progene_text",
"text": [
"growth factor"
],
"offsets": [
[
164,
177
]
],
"normalized": []
},
{
"id": "split_0_train_47099_entity",
"type": "progene_text",
"text": [
"vascular endothelial growth factor"
],
"offsets": [
[
210,
244
]
],
"normalized": []
},
{
"id": "split_0_train_47100_entity",
"type": "progene_text",
"text": [
"PDGF A"
],
"offsets": [
[
258,
264
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28985
|
split_0_train_28985
|
[
{
"id": "split_0_train_28985_passage",
"type": "progene_text",
"text": [
"A serum - sensitive cleavage site between the two domains allows release of the GFD from the CUB domain ."
],
"offsets": [
[
0,
105
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28986
|
split_0_train_28986
|
[
{
"id": "split_0_train_28986_passage",
"type": "progene_text",
"text": [
"Competition binding and immunoprecipitation studies on cells bearing both PDGF alpha and beta receptors reveal a high affinity binding of recombinant GFD ( PDGF-CC ) to PDGF receptor - alpha homodimers and PDGF receptor - alpha / beta heterodimers ."
],
"offsets": [
[
0,
249
]
]
}
] |
[
{
"id": "split_0_train_47101_entity",
"type": "progene_text",
"text": [
"PDGF alpha and beta receptors"
],
"offsets": [
[
74,
103
]
],
"normalized": []
},
{
"id": "split_0_train_47102_entity",
"type": "progene_text",
"text": [
"PDGF-CC"
],
"offsets": [
[
156,
163
]
],
"normalized": []
},
{
"id": "split_0_train_47103_entity",
"type": "progene_text",
"text": [
"PDGF receptor - alpha"
],
"offsets": [
[
169,
190
]
],
"normalized": []
},
{
"id": "split_0_train_47104_entity",
"type": "progene_text",
"text": [
"PDGF receptor - alpha / beta"
],
"offsets": [
[
206,
234
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28987
|
split_0_train_28987
|
[
{
"id": "split_0_train_28987_passage",
"type": "progene_text",
"text": [
"PDGF-CC exhibits greater mitogenic potency than PDGF-AA and comparable or greater mitogenic activity than PDGF-AB and PDGF-BB on several mesenchymal cell types ."
],
"offsets": [
[
0,
161
]
]
}
] |
[
{
"id": "split_0_train_47105_entity",
"type": "progene_text",
"text": [
"PDGF-CC"
],
"offsets": [
[
0,
7
]
],
"normalized": []
},
{
"id": "split_0_train_47106_entity",
"type": "progene_text",
"text": [
"PDGF-AA"
],
"offsets": [
[
48,
55
]
],
"normalized": []
},
{
"id": "split_0_train_47107_entity",
"type": "progene_text",
"text": [
"PDGF-AB"
],
"offsets": [
[
106,
113
]
],
"normalized": []
},
{
"id": "split_0_train_47108_entity",
"type": "progene_text",
"text": [
"PDGF-BB"
],
"offsets": [
[
118,
125
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28988
|
split_0_train_28988
|
[
{
"id": "split_0_train_28988_passage",
"type": "progene_text",
"text": [
"Analysis of PDGF-CC in vivo in a diabetic mouse model of delayed wound healing showed that PDGF-CC significantly enhanced repair of a full - thickness skin excision ."
],
"offsets": [
[
0,
166
]
]
}
] |
[
{
"id": "split_0_train_47109_entity",
"type": "progene_text",
"text": [
"PDGF-CC"
],
"offsets": [
[
12,
19
]
],
"normalized": []
},
{
"id": "split_0_train_47110_entity",
"type": "progene_text",
"text": [
"PDGF-CC"
],
"offsets": [
[
91,
98
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28989
|
split_0_train_28989
|
[
{
"id": "split_0_train_28989_passage",
"type": "progene_text",
"text": [
"Together , these studies describe a third member of the PDGF family ( PDGF-C ) as a potent mitogen for cells of mesenchymal origin in in vitro and in vivo systems with a binding pattern similar to PDGF-AB ."
],
"offsets": [
[
0,
206
]
]
}
] |
[
{
"id": "split_0_train_47111_entity",
"type": "progene_text",
"text": [
"PDGF family"
],
"offsets": [
[
56,
67
]
],
"normalized": []
},
{
"id": "split_0_train_47112_entity",
"type": "progene_text",
"text": [
"PDGF-C"
],
"offsets": [
[
70,
76
]
],
"normalized": []
},
{
"id": "split_0_train_47113_entity",
"type": "progene_text",
"text": [
"PDGF-AB"
],
"offsets": [
[
197,
204
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28990
|
split_0_train_28990
|
[
{
"id": "split_0_train_28990_passage",
"type": "progene_text",
"text": [
"A novel actin - related protein gene of Colletotrichum gloeosporioides f. sp. malvae shows altered expression corresponding with spore production ."
],
"offsets": [
[
0,
147
]
]
}
] |
[
{
"id": "split_0_train_47114_entity",
"type": "progene_text",
"text": [
"actin - related protein"
],
"offsets": [
[
8,
31
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28991
|
split_0_train_28991
|
[
{
"id": "split_0_train_28991_passage",
"type": "progene_text",
"text": [
"A novel actin - related protein ( arp ) was found in the plant pathogenic fungus , Colletotrichum gloeosporioides f. sp. malvae ( Cgm ) , which causes anthracnose disease of round - leaved mallow ( Malva pusilla ) ."
],
"offsets": [
[
0,
215
]
]
}
] |
[
{
"id": "split_0_train_47115_entity",
"type": "progene_text",
"text": [
"actin - related protein"
],
"offsets": [
[
8,
31
]
],
"normalized": []
},
{
"id": "split_0_train_47116_entity",
"type": "progene_text",
"text": [
"arp"
],
"offsets": [
[
34,
37
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28992
|
split_0_train_28992
|
[
{
"id": "split_0_train_28992_passage",
"type": "progene_text",
"text": [
"Sequence comparisons showed that this gene , arpA , belongs to the highly divergent ' other arps ' category in the current arp classification system ."
],
"offsets": [
[
0,
150
]
]
}
] |
[
{
"id": "split_0_train_47117_entity",
"type": "progene_text",
"text": [
"arpA"
],
"offsets": [
[
45,
49
]
],
"normalized": []
},
{
"id": "split_0_train_47118_entity",
"type": "progene_text",
"text": [
"arps"
],
"offsets": [
[
92,
96
]
],
"normalized": []
},
{
"id": "split_0_train_47119_entity",
"type": "progene_text",
"text": [
"arp"
],
"offsets": [
[
123,
126
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28993
|
split_0_train_28993
|
[
{
"id": "split_0_train_28993_passage",
"type": "progene_text",
"text": [
"ArpA is most similar to the arp11 gene of Mus musculus but has a unique structure with deletions at the C - terminus similar to that of the arp10 gene of Saccharomyces cerevisiae ."
],
"offsets": [
[
0,
180
]
]
}
] |
[
{
"id": "split_0_train_47120_entity",
"type": "progene_text",
"text": [
"ArpA"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_47121_entity",
"type": "progene_text",
"text": [
"arp11"
],
"offsets": [
[
28,
33
]
],
"normalized": []
},
{
"id": "split_0_train_47122_entity",
"type": "progene_text",
"text": [
"arp10"
],
"offsets": [
[
140,
145
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28994
|
split_0_train_28994
|
[
{
"id": "split_0_train_28994_passage",
"type": "progene_text",
"text": [
"A portion of another putative arp gene , arpB , was found immediately downstream of arpA ."
],
"offsets": [
[
0,
90
]
]
}
] |
[
{
"id": "split_0_train_47123_entity",
"type": "progene_text",
"text": [
"arp"
],
"offsets": [
[
30,
33
]
],
"normalized": []
},
{
"id": "split_0_train_47124_entity",
"type": "progene_text",
"text": [
"arpB"
],
"offsets": [
[
41,
45
]
],
"normalized": []
},
{
"id": "split_0_train_47125_entity",
"type": "progene_text",
"text": [
"arpA"
],
"offsets": [
[
84,
88
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28995
|
split_0_train_28995
|
[
{
"id": "split_0_train_28995_passage",
"type": "progene_text",
"text": [
"Expression of arpA was compared to the constitutively expressed Cgm actin gene , actA ."
],
"offsets": [
[
0,
87
]
]
}
] |
[
{
"id": "split_0_train_47126_entity",
"type": "progene_text",
"text": [
"arpA"
],
"offsets": [
[
14,
18
]
],
"normalized": []
},
{
"id": "split_0_train_47127_entity",
"type": "progene_text",
"text": [
"actin"
],
"offsets": [
[
68,
73
]
],
"normalized": []
},
{
"id": "split_0_train_47128_entity",
"type": "progene_text",
"text": [
"actA"
],
"offsets": [
[
81,
85
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28996
|
split_0_train_28996
|
[
{
"id": "split_0_train_28996_passage",
"type": "progene_text",
"text": [
"In culture , the relative expression of arpA increased when growth conditions favored sporulation ."
],
"offsets": [
[
0,
99
]
]
}
] |
[
{
"id": "split_0_train_47129_entity",
"type": "progene_text",
"text": [
"arpA"
],
"offsets": [
[
40,
44
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28997
|
split_0_train_28997
|
[
{
"id": "split_0_train_28997_passage",
"type": "progene_text",
"text": [
"During infection , arpA expression was greatest at the late necrotrophic phase , when sporulation occurred ."
],
"offsets": [
[
0,
108
]
]
}
] |
[
{
"id": "split_0_train_47130_entity",
"type": "progene_text",
"text": [
"arpA"
],
"offsets": [
[
19,
23
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28998
|
split_0_train_28998
|
[
{
"id": "split_0_train_28998_passage",
"type": "progene_text",
"text": [
"Arps have been shown to be important in nuclear migration in fungal hyphae , and the expression pattern of arpA indicates that it may have a particular role during sporulation ."
],
"offsets": [
[
0,
177
]
]
}
] |
[
{
"id": "split_0_train_47131_entity",
"type": "progene_text",
"text": [
"Arps"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_47132_entity",
"type": "progene_text",
"text": [
"arpA"
],
"offsets": [
[
107,
111
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28999
|
split_0_train_28999
|
[
{
"id": "split_0_train_28999_passage",
"type": "progene_text",
"text": [
"Molecular cloning and characterization of a novel human galactose 3-O-sulfotransferase that transfers sulfate to gal beta 1 --> 3galNAc residue in O-glycans ."
],
"offsets": [
[
0,
158
]
]
}
] |
[
{
"id": "split_0_train_47133_entity",
"type": "progene_text",
"text": [
"galactose 3-O-sulfotransferase"
],
"offsets": [
[
56,
86
]
],
"normalized": []
}
] |
[] |
[] |
[] |
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