id
stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
split_0_train_28700
|
split_0_train_28700
|
[
{
"id": "split_0_train_28700_passage",
"type": "progene_text",
"text": [
"The resulting cDNAs were polymerase chain reaction amplified , sequenced , and eight variant loci were identified ."
],
"offsets": [
[
0,
115
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28701
|
split_0_train_28701
|
[
{
"id": "split_0_train_28701_passage",
"type": "progene_text",
"text": [
"The coding region contained five silent single nucleotide polymorphisms ( SNPs ) and two variant loci resulting in altered protein sequence ."
],
"offsets": [
[
0,
141
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28702
|
split_0_train_28702
|
[
{
"id": "split_0_train_28702_passage",
"type": "progene_text",
"text": [
"An amino acid substitution was identified at residue 287 in exon 8 , where the more common arginine was replaced by glutamine ."
],
"offsets": [
[
0,
127
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28703
|
split_0_train_28703
|
[
{
"id": "split_0_train_28703_passage",
"type": "progene_text",
"text": [
"A second variant locus was identified in exon 13 where an arginine residue was inserted following serine 402 resulting in the sequence , arginine 403 - 404 , instead of the more common , arginine 403 ."
],
"offsets": [
[
0,
201
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28704
|
split_0_train_28704
|
[
{
"id": "split_0_train_28704_passage",
"type": "progene_text",
"text": [
"This amino acid insertion was confirmed by analyzing genomic DNA from individuals harboring the polymorphic allele ."
],
"offsets": [
[
0,
116
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28705
|
split_0_train_28705
|
[
{
"id": "split_0_train_28705_passage",
"type": "progene_text",
"text": [
"Slot blot hybridization analyses of the liver samples indicated that sEH mRNA steady - state expression varied approximately 10 - fold ."
],
"offsets": [
[
0,
136
]
]
}
] |
[
{
"id": "split_0_train_46504_entity",
"type": "progene_text",
"text": [
"sEH"
],
"offsets": [
[
69,
72
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28706
|
split_0_train_28706
|
[
{
"id": "split_0_train_28706_passage",
"type": "progene_text",
"text": [
"Transient transfection experiments with CHO and COS-7 cells were used to demonstrate that the two new alleles possess catalytic activity using trans - stilbene oxide as a model substrate ."
],
"offsets": [
[
0,
188
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28707
|
split_0_train_28707
|
[
{
"id": "split_0_train_28707_passage",
"type": "progene_text",
"text": [
"Although the activity of the glutamine 287 variant was similar to the sEH wild type allele , proteins containing the arginine insertion exhibited strikingly lower activity ."
],
"offsets": [
[
0,
173
]
]
}
] |
[
{
"id": "split_0_train_46505_entity",
"type": "progene_text",
"text": [
"sEH"
],
"offsets": [
[
70,
73
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28708
|
split_0_train_28708
|
[
{
"id": "split_0_train_28708_passage",
"type": "progene_text",
"text": [
"Allelic forms of human sEH , with markedly different enzymatic profiles , may have important physiological implications with respect to the disposition of epoxides formed from the oxidation of fatty acids , such as arachidonic acid - derived intermediates , as well in the regulation of toxicity due to xenobiotic epoxide exposures ."
],
"offsets": [
[
0,
333
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]
}
] |
[
{
"id": "split_0_train_46506_entity",
"type": "progene_text",
"text": [
"sEH"
],
"offsets": [
[
23,
26
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28709
|
split_0_train_28709
|
[
{
"id": "split_0_train_28709_passage",
"type": "progene_text",
"text": [
"Isolation of two novel human RhoGEFs , ARHGEF3 and ARHGEF4 , in 3p13 - 21 and 2q22 ."
],
"offsets": [
[
0,
84
]
]
}
] |
[
{
"id": "split_0_train_46507_entity",
"type": "progene_text",
"text": [
"RhoGEFs"
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"offsets": [
[
29,
36
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{
"id": "split_0_train_46508_entity",
"type": "progene_text",
"text": [
"ARHGEF3"
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39,
46
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{
"id": "split_0_train_46509_entity",
"type": "progene_text",
"text": [
"ARHGEF4"
],
"offsets": [
[
51,
58
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28710
|
split_0_train_28710
|
[
{
"id": "split_0_train_28710_passage",
"type": "progene_text",
"text": [
"RhoGEFs play an important role in various signaling cascades and are implicated in human conditions like cancer and mental retardation ."
],
"offsets": [
[
0,
136
]
]
}
] |
[
{
"id": "split_0_train_46510_entity",
"type": "progene_text",
"text": [
"RhoGEFs"
],
"offsets": [
[
0,
7
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28711
|
split_0_train_28711
|
[
{
"id": "split_0_train_28711_passage",
"type": "progene_text",
"text": [
"A database search combined with screening of a human neuronal teratocarcinoma library identified two novel RhoGEFs , ARHGEF3 and ARHGEF4 ( HGMW-approved symbols ) ."
],
"offsets": [
[
0,
164
]
]
}
] |
[
{
"id": "split_0_train_46511_entity",
"type": "progene_text",
"text": [
"RhoGEFs"
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"offsets": [
[
107,
114
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],
"normalized": []
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{
"id": "split_0_train_46512_entity",
"type": "progene_text",
"text": [
"ARHGEF3"
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"offsets": [
[
117,
124
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],
"normalized": []
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{
"id": "split_0_train_46513_entity",
"type": "progene_text",
"text": [
"ARHGEF4"
],
"offsets": [
[
129,
136
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28712
|
split_0_train_28712
|
[
{
"id": "split_0_train_28712_passage",
"type": "progene_text",
"text": [
"The widely expressed ARHGEF3 transcript of 3561 nucleotides encodes a polypeptide of 526 amino acids with homology to NET1 ."
],
"offsets": [
[
0,
124
]
]
}
] |
[
{
"id": "split_0_train_46514_entity",
"type": "progene_text",
"text": [
"ARHGEF3"
],
"offsets": [
[
21,
28
]
],
"normalized": []
},
{
"id": "split_0_train_46515_entity",
"type": "progene_text",
"text": [
"NET1"
],
"offsets": [
[
118,
122
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28713
|
split_0_train_28713
|
[
{
"id": "split_0_train_28713_passage",
"type": "progene_text",
"text": [
"The ARHGEF4 gene generates two transcripts of 3665 and 4000 nucleotides that translate into 720 amino acid residues ."
],
"offsets": [
[
0,
117
]
]
}
] |
[
{
"id": "split_0_train_46516_entity",
"type": "progene_text",
"text": [
"ARHGEF4"
],
"offsets": [
[
4,
11
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28714
|
split_0_train_28714
|
[
{
"id": "split_0_train_28714_passage",
"type": "progene_text",
"text": [
"Expression of ARHGEF4 is restricted to brain and the encoded protein shows homology to collybistin ."
],
"offsets": [
[
0,
100
]
]
}
] |
[
{
"id": "split_0_train_46517_entity",
"type": "progene_text",
"text": [
"ARHGEF4"
],
"offsets": [
[
14,
21
]
],
"normalized": []
},
{
"id": "split_0_train_46518_entity",
"type": "progene_text",
"text": [
"collybistin"
],
"offsets": [
[
87,
98
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28715
|
split_0_train_28715
|
[
{
"id": "split_0_train_28715_passage",
"type": "progene_text",
"text": [
"FISH analysis of genomic clones mapped ARHGEF3 to 3p13-21 and ARHGEF4 to 2q22 ."
],
"offsets": [
[
0,
79
]
]
}
] |
[
{
"id": "split_0_train_46519_entity",
"type": "progene_text",
"text": [
"ARHGEF3"
],
"offsets": [
[
39,
46
]
],
"normalized": []
},
{
"id": "split_0_train_46520_entity",
"type": "progene_text",
"text": [
"ARHGEF4"
],
"offsets": [
[
62,
69
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28716
|
split_0_train_28716
|
[
{
"id": "split_0_train_28716_passage",
"type": "progene_text",
"text": [
"Identification of regions within the third FnIII - like domain of the IL-5Ralpha involved in IL-5 interaction ."
],
"offsets": [
[
0,
111
]
]
}
] |
[
{
"id": "split_0_train_46521_entity",
"type": "progene_text",
"text": [
"IL-5Ralpha"
],
"offsets": [
[
70,
80
]
],
"normalized": []
},
{
"id": "split_0_train_46522_entity",
"type": "progene_text",
"text": [
"IL-5"
],
"offsets": [
[
93,
97
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28717
|
split_0_train_28717
|
[
{
"id": "split_0_train_28717_passage",
"type": "progene_text",
"text": [
"Previously , two binding sites for interleukin 5 ( IL-5 ) were identified on the IL-5 receptor alpha chain ( IL-5Ralpha ) ."
],
"offsets": [
[
0,
123
]
]
}
] |
[
{
"id": "split_0_train_46523_entity",
"type": "progene_text",
"text": [
"interleukin 5"
],
"offsets": [
[
35,
48
]
],
"normalized": []
},
{
"id": "split_0_train_46524_entity",
"type": "progene_text",
"text": [
"IL-5"
],
"offsets": [
[
51,
55
]
],
"normalized": []
},
{
"id": "split_0_train_46525_entity",
"type": "progene_text",
"text": [
"IL-5 receptor alpha"
],
"offsets": [
[
81,
100
]
],
"normalized": []
},
{
"id": "split_0_train_46526_entity",
"type": "progene_text",
"text": [
"IL-5Ralpha"
],
"offsets": [
[
109,
119
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28718
|
split_0_train_28718
|
[
{
"id": "split_0_train_28718_passage",
"type": "progene_text",
"text": [
"They are located within the CD loop of the first fibronectin type III ( FnIII ) - like domain and the EF loop of the second FnIII - like domain ."
],
"offsets": [
[
0,
145
]
]
}
] |
[
{
"id": "split_0_train_46527_entity",
"type": "progene_text",
"text": [
"fibronectin"
],
"offsets": [
[
49,
60
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28719
|
split_0_train_28719
|
[
{
"id": "split_0_train_28719_passage",
"type": "progene_text",
"text": [
"The first binding site was identified by exploiting the different abilities of human IL-5Ralpha ( hIL-5Ralpha ) and mouse IL-5Ralpha ( mIL-5Ralpha ) to bind hIL-5 ."
],
"offsets": [
[
0,
164
]
]
}
] |
[
{
"id": "split_0_train_46528_entity",
"type": "progene_text",
"text": [
"IL-5Ralpha"
],
"offsets": [
[
85,
95
]
],
"normalized": []
},
{
"id": "split_0_train_46529_entity",
"type": "progene_text",
"text": [
"hIL-5Ralpha"
],
"offsets": [
[
98,
109
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],
"normalized": []
},
{
"id": "split_0_train_46530_entity",
"type": "progene_text",
"text": [
"IL-5Ralpha"
],
"offsets": [
[
122,
132
]
],
"normalized": []
},
{
"id": "split_0_train_46531_entity",
"type": "progene_text",
"text": [
"mIL-5Ralpha"
],
"offsets": [
[
135,
146
]
],
"normalized": []
},
{
"id": "split_0_train_46532_entity",
"type": "progene_text",
"text": [
"hIL-5"
],
"offsets": [
[
157,
162
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28720
|
split_0_train_28720
|
[
{
"id": "split_0_train_28720_passage",
"type": "progene_text",
"text": [
"Here we show that ovine IL-5 ( oIL-5 ) has the ability to activate the hIL-5Ralpha but not the mIL-5Ralpha ."
],
"offsets": [
[
0,
108
]
]
}
] |
[
{
"id": "split_0_train_46533_entity",
"type": "progene_text",
"text": [
"IL-5"
],
"offsets": [
[
24,
28
]
],
"normalized": []
},
{
"id": "split_0_train_46534_entity",
"type": "progene_text",
"text": [
"oIL-5"
],
"offsets": [
[
31,
36
]
],
"normalized": []
},
{
"id": "split_0_train_46535_entity",
"type": "progene_text",
"text": [
"hIL-5Ralpha"
],
"offsets": [
[
71,
82
]
],
"normalized": []
},
{
"id": "split_0_train_46536_entity",
"type": "progene_text",
"text": [
"mIL-5Ralpha"
],
"offsets": [
[
95,
106
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28721
|
split_0_train_28721
|
[
{
"id": "split_0_train_28721_passage",
"type": "progene_text",
"text": [
"By using chimeras of the mIL-5Ralpha and hIL-5Ralpha we demonstrate that residues within the first and third FnIII - like domains of mIL-5Ralpha are responsible for this lack of activity ."
],
"offsets": [
[
0,
188
]
]
}
] |
[
{
"id": "split_0_train_46537_entity",
"type": "progene_text",
"text": [
"mIL-5Ralpha"
],
"offsets": [
[
25,
36
]
],
"normalized": []
},
{
"id": "split_0_train_46538_entity",
"type": "progene_text",
"text": [
"hIL-5Ralpha"
],
"offsets": [
[
41,
52
]
],
"normalized": []
},
{
"id": "split_0_train_46539_entity",
"type": "progene_text",
"text": [
"mIL-5Ralpha"
],
"offsets": [
[
133,
144
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28722
|
split_0_train_28722
|
[
{
"id": "split_0_train_28722_passage",
"type": "progene_text",
"text": [
"Furthermore , mutation of residues on hIL-5Ralpha to mIL-5Ralpha within the predicted DE and FG loop regions of the third FnIII domain reduces oIL-5 activity ."
],
"offsets": [
[
0,
159
]
]
}
] |
[
{
"id": "split_0_train_46540_entity",
"type": "progene_text",
"text": [
"hIL-5Ralpha"
],
"offsets": [
[
38,
49
]
],
"normalized": []
},
{
"id": "split_0_train_46541_entity",
"type": "progene_text",
"text": [
"mIL-5Ralpha"
],
"offsets": [
[
53,
64
]
],
"normalized": []
},
{
"id": "split_0_train_46542_entity",
"type": "progene_text",
"text": [
"oIL-5"
],
"offsets": [
[
143,
148
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28723
|
split_0_train_28723
|
[
{
"id": "split_0_train_28723_passage",
"type": "progene_text",
"text": [
"These results show that regions of the third FnIII domain of IL-5Ralpha are involved in binding , in addition to the regions in domains one and two of the IL-5Ralpha that were identified in an earlier study ."
],
"offsets": [
[
0,
208
]
]
}
] |
[
{
"id": "split_0_train_46543_entity",
"type": "progene_text",
"text": [
"IL-5Ralpha"
],
"offsets": [
[
61,
71
]
],
"normalized": []
},
{
"id": "split_0_train_46544_entity",
"type": "progene_text",
"text": [
"IL-5Ralpha"
],
"offsets": [
[
155,
165
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28724
|
split_0_train_28724
|
[
{
"id": "split_0_train_28724_passage",
"type": "progene_text",
"text": [
"Rescue of human T cells by interleukin-9 ( IL-9 ) from IL-2 deprivation - induced apoptosis : correlation with alpha subunit expression of the IL-9 receptor ."
],
"offsets": [
[
0,
158
]
]
}
] |
[
{
"id": "split_0_train_46545_entity",
"type": "progene_text",
"text": [
"interleukin-9"
],
"offsets": [
[
27,
40
]
],
"normalized": []
},
{
"id": "split_0_train_46546_entity",
"type": "progene_text",
"text": [
"IL-9"
],
"offsets": [
[
43,
47
]
],
"normalized": []
},
{
"id": "split_0_train_46547_entity",
"type": "progene_text",
"text": [
"IL-2"
],
"offsets": [
[
55,
59
]
],
"normalized": []
},
{
"id": "split_0_train_46548_entity",
"type": "progene_text",
"text": [
"IL-9 receptor"
],
"offsets": [
[
143,
156
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28725
|
split_0_train_28725
|
[
{
"id": "split_0_train_28725_passage",
"type": "progene_text",
"text": [
"Interleukin-9 ( IL-9 ) is a Th2 - derived cytokine that uses the gamma - chain of the IL-2 receptor for signaling ."
],
"offsets": [
[
0,
115
]
]
}
] |
[
{
"id": "split_0_train_46549_entity",
"type": "progene_text",
"text": [
"Interleukin-9"
],
"offsets": [
[
0,
13
]
],
"normalized": []
},
{
"id": "split_0_train_46550_entity",
"type": "progene_text",
"text": [
"IL-9"
],
"offsets": [
[
16,
20
]
],
"normalized": []
},
{
"id": "split_0_train_46551_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
42,
50
]
],
"normalized": []
},
{
"id": "split_0_train_46552_entity",
"type": "progene_text",
"text": [
"gamma - chain of the IL-2 receptor"
],
"offsets": [
[
65,
99
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28726
|
split_0_train_28726
|
[
{
"id": "split_0_train_28726_passage",
"type": "progene_text",
"text": [
"Therefore , the responsiveness of human Th1 and Th2 cell clones to IL-9 was measured by examining the ability of this cytokine to prevent apoptosis induced by IL-2 deprivation ."
],
"offsets": [
[
0,
177
]
]
}
] |
[
{
"id": "split_0_train_46553_entity",
"type": "progene_text",
"text": [
"IL-9"
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"offsets": [
[
67,
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"normalized": []
},
{
"id": "split_0_train_46554_entity",
"type": "progene_text",
"text": [
"cytokine"
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118,
126
]
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"normalized": []
},
{
"id": "split_0_train_46555_entity",
"type": "progene_text",
"text": [
"IL-2"
],
"offsets": [
[
159,
163
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28727
|
split_0_train_28727
|
[
{
"id": "split_0_train_28727_passage",
"type": "progene_text",
"text": [
"A time course study demonstrated that both subsets of T cell clones underwent apoptosis with similar kinetics when deprived of IL-2 and that viability could be maintained by the addition of either IL-4 or IL-7 ."
],
"offsets": [
[
0,
211
]
]
}
] |
[
{
"id": "split_0_train_46556_entity",
"type": "progene_text",
"text": [
"IL-2"
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"offsets": [
[
127,
131
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],
"normalized": []
},
{
"id": "split_0_train_46557_entity",
"type": "progene_text",
"text": [
"IL-4"
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197,
201
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],
"normalized": []
},
{
"id": "split_0_train_46558_entity",
"type": "progene_text",
"text": [
"IL-7"
],
"offsets": [
[
205,
209
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28728
|
split_0_train_28728
|
[
{
"id": "split_0_train_28728_passage",
"type": "progene_text",
"text": [
"Interestingly , IL-9 prevented apoptosis in only 2 ( Th2 ) of 14 clones tested ."
],
"offsets": [
[
0,
80
]
]
}
] |
[
{
"id": "split_0_train_46559_entity",
"type": "progene_text",
"text": [
"IL-9"
],
"offsets": [
[
16,
20
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28729
|
split_0_train_28729
|
[
{
"id": "split_0_train_28729_passage",
"type": "progene_text",
"text": [
"Analysis of IL-9R alpha subunit expression on 18 T cell clones revealed that IL-9 responsiveness was directly proportional to the expression of the high - affinity receptor ."
],
"offsets": [
[
0,
174
]
]
}
] |
[
{
"id": "split_0_train_46560_entity",
"type": "progene_text",
"text": [
"IL-9R alpha"
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"offsets": [
[
12,
23
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],
"normalized": []
},
{
"id": "split_0_train_46561_entity",
"type": "progene_text",
"text": [
"IL-9"
],
"offsets": [
[
77,
81
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28730
|
split_0_train_28730
|
[
{
"id": "split_0_train_28730_passage",
"type": "progene_text",
"text": [
"IL-9 responsiveness was also dependent on long - term culturing because neither freshly isolated nor 3 - day phytohemagglutinin ( PHA ) - stimulated peripheral blood lymphocytes ( PBL ) expressed IL-9R alpha ."
],
"offsets": [
[
0,
209
]
]
}
] |
[
{
"id": "split_0_train_46562_entity",
"type": "progene_text",
"text": [
"IL-9"
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[
0,
4
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},
{
"id": "split_0_train_46563_entity",
"type": "progene_text",
"text": [
"phytohemagglutinin"
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[
109,
127
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],
"normalized": []
},
{
"id": "split_0_train_46564_entity",
"type": "progene_text",
"text": [
"PHA"
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[
130,
133
]
],
"normalized": []
},
{
"id": "split_0_train_46565_entity",
"type": "progene_text",
"text": [
"IL-9R alpha"
],
"offsets": [
[
196,
207
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28731
|
split_0_train_28731
|
[
{
"id": "split_0_train_28731_passage",
"type": "progene_text",
"text": [
"In summary , the data showed that IL-9 can rescue only a small subset of Th2 cells from apoptosis induced by growth factor withdrawal and that expression of IL-9R alpha is required for the antiapoptotic signals mediated by this cytokine ."
],
"offsets": [
[
0,
238
]
]
}
] |
[
{
"id": "split_0_train_46566_entity",
"type": "progene_text",
"text": [
"IL-9"
],
"offsets": [
[
34,
38
]
],
"normalized": []
},
{
"id": "split_0_train_46567_entity",
"type": "progene_text",
"text": [
"growth factor"
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[
109,
122
]
],
"normalized": []
},
{
"id": "split_0_train_46568_entity",
"type": "progene_text",
"text": [
"IL-9R alpha"
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"offsets": [
[
157,
168
]
],
"normalized": []
},
{
"id": "split_0_train_46569_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
228,
236
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28732
|
split_0_train_28732
|
[
{
"id": "split_0_train_28732_passage",
"type": "progene_text",
"text": [
"Characterization of LrpC DNA - binding properties and regulation of Bacillus subtilis lrpC gene expression ."
],
"offsets": [
[
0,
108
]
]
}
] |
[
{
"id": "split_0_train_46570_entity",
"type": "progene_text",
"text": [
"LrpC"
],
"offsets": [
[
20,
24
]
],
"normalized": []
},
{
"id": "split_0_train_46571_entity",
"type": "progene_text",
"text": [
"lrpC"
],
"offsets": [
[
86,
90
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28733
|
split_0_train_28733
|
[
{
"id": "split_0_train_28733_passage",
"type": "progene_text",
"text": [
"The lrpC gene was identified during the Bacillus subtilis genome sequencing project ."
],
"offsets": [
[
0,
85
]
]
}
] |
[
{
"id": "split_0_train_46572_entity",
"type": "progene_text",
"text": [
"lrpC"
],
"offsets": [
[
4,
8
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28734
|
split_0_train_28734
|
[
{
"id": "split_0_train_28734_passage",
"type": "progene_text",
"text": [
"Previous experiments suggested that LrpC has a role in sporulation and in the regulation of amino acid metabolism and that it shares features with Escherichia coli Lrp , a transcription regulator ( C. Beloin , S. Ayora , R. Exley , L. Hirschbein , N. Ogasawara , Y. Kasahara , J. C. Alonso , and F. Le H�©garat , Mol. Gen. Genet. 256 : 63 - 71 , 1997 ) ."
],
"offsets": [
[
0,
356
]
]
}
] |
[
{
"id": "split_0_train_46573_entity",
"type": "progene_text",
"text": [
"LrpC"
],
"offsets": [
[
36,
40
]
],
"normalized": []
},
{
"id": "split_0_train_46574_entity",
"type": "progene_text",
"text": [
"Lrp"
],
"offsets": [
[
164,
167
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28735
|
split_0_train_28735
|
[
{
"id": "split_0_train_28735_passage",
"type": "progene_text",
"text": [
"To characterize the interactions of LrpC with DNA , the protein was overproduced and purified ."
],
"offsets": [
[
0,
95
]
]
}
] |
[
{
"id": "split_0_train_46575_entity",
"type": "progene_text",
"text": [
"LrpC"
],
"offsets": [
[
36,
40
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28736
|
split_0_train_28736
|
[
{
"id": "split_0_train_28736_passage",
"type": "progene_text",
"text": [
"We show that LrpC binds to multiple sites in the upstream region of its own gene with a stronger affinity for a region encompassing P1 , one of the putative promoters identified ( P1 and P2 ) ."
],
"offsets": [
[
0,
193
]
]
}
] |
[
{
"id": "split_0_train_46576_entity",
"type": "progene_text",
"text": [
"LrpC"
],
"offsets": [
[
13,
17
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28737
|
split_0_train_28737
|
[
{
"id": "split_0_train_28737_passage",
"type": "progene_text",
"text": [
"By analyzing lrpC - lacZ transcriptional fusions , we demonstrated that P1 is the major in vivo promoter and that , unlike many members of the lrp / asnC family , lrpC is not negatively autoregulated but rather slightly positively autoregulated ."
],
"offsets": [
[
0,
246
]
]
}
] |
[
{
"id": "split_0_train_46577_entity",
"type": "progene_text",
"text": [
"lrpC"
],
"offsets": [
[
13,
17
]
],
"normalized": []
},
{
"id": "split_0_train_46578_entity",
"type": "progene_text",
"text": [
"lacZ"
],
"offsets": [
[
20,
24
]
],
"normalized": []
},
{
"id": "split_0_train_46579_entity",
"type": "progene_text",
"text": [
"lrp / asnC family"
],
"offsets": [
[
143,
160
]
],
"normalized": []
},
{
"id": "split_0_train_46580_entity",
"type": "progene_text",
"text": [
"lrpC"
],
"offsets": [
[
163,
167
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28738
|
split_0_train_28738
|
[
{
"id": "split_0_train_28738_passage",
"type": "progene_text",
"text": [
"Production of LrpC in vivo is low in both rich and minimal media ( 50 to 300 LrpC molecules per cell ) ."
],
"offsets": [
[
0,
104
]
]
}
] |
[
{
"id": "split_0_train_46581_entity",
"type": "progene_text",
"text": [
"LrpC"
],
"offsets": [
[
14,
18
]
],
"normalized": []
},
{
"id": "split_0_train_46582_entity",
"type": "progene_text",
"text": [
"LrpC"
],
"offsets": [
[
77,
81
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28739
|
split_0_train_28739
|
[
{
"id": "split_0_train_28739_passage",
"type": "progene_text",
"text": [
"In rich medium , the cellular LrpC content is six - to sevenfold lower during the exponentional phase than during the stationary growth phase ."
],
"offsets": [
[
0,
143
]
]
}
] |
[
{
"id": "split_0_train_46583_entity",
"type": "progene_text",
"text": [
"LrpC"
],
"offsets": [
[
30,
34
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28740
|
split_0_train_28740
|
[
{
"id": "split_0_train_28740_passage",
"type": "progene_text",
"text": [
"Possible determinants and the biological significance of the regulation of lrpC expression are discussed ."
],
"offsets": [
[
0,
106
]
]
}
] |
[
{
"id": "split_0_train_46584_entity",
"type": "progene_text",
"text": [
"lrpC"
],
"offsets": [
[
75,
79
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28741
|
split_0_train_28741
|
[
{
"id": "split_0_train_28741_passage",
"type": "progene_text",
"text": [
"Regulation of the promoter activity of interferon regulatory factor-7 gene ."
],
"offsets": [
[
0,
76
]
]
}
] |
[
{
"id": "split_0_train_46585_entity",
"type": "progene_text",
"text": [
"interferon regulatory factor-7"
],
"offsets": [
[
39,
69
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28742
|
split_0_train_28742
|
[
{
"id": "split_0_train_28742_passage",
"type": "progene_text",
"text": [
"Activation by interferon snd silencing by hypermethylation ."
],
"offsets": [
[
0,
60
]
]
}
] |
[
{
"id": "split_0_train_46586_entity",
"type": "progene_text",
"text": [
"interferon"
],
"offsets": [
[
14,
24
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28743
|
split_0_train_28743
|
[
{
"id": "split_0_train_28743_passage",
"type": "progene_text",
"text": [
"The molecular mechanism by which virus induces expression of the early inflammatory genes has not yet been completely elucidated ."
],
"offsets": [
[
0,
130
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28744
|
split_0_train_28744
|
[
{
"id": "split_0_train_28744_passage",
"type": "progene_text",
"text": [
"Previous studies indicated that the virus - mediated transcription of type I interferon ( IFN ) genes required activation of two members of IFN regulatory factor ( IRF ) family , IRF-3 and IRF-7 , where the expression of IRF-7 was found to be indispensable for the induction of IFNA genes ."
],
"offsets": [
[
0,
290
]
]
}
] |
[
{
"id": "split_0_train_46587_entity",
"type": "progene_text",
"text": [
"type I interferon"
],
"offsets": [
[
70,
87
]
],
"normalized": []
},
{
"id": "split_0_train_46588_entity",
"type": "progene_text",
"text": [
"IFN"
],
"offsets": [
[
90,
93
]
],
"normalized": []
},
{
"id": "split_0_train_46589_entity",
"type": "progene_text",
"text": [
"IFN regulatory factor ( IRF ) family"
],
"offsets": [
[
140,
176
]
],
"normalized": []
},
{
"id": "split_0_train_46590_entity",
"type": "progene_text",
"text": [
"IRF-3"
],
"offsets": [
[
179,
184
]
],
"normalized": []
},
{
"id": "split_0_train_46591_entity",
"type": "progene_text",
"text": [
"IRF-7"
],
"offsets": [
[
189,
194
]
],
"normalized": []
},
{
"id": "split_0_train_46592_entity",
"type": "progene_text",
"text": [
"IRF-7"
],
"offsets": [
[
221,
226
]
],
"normalized": []
},
{
"id": "split_0_train_46593_entity",
"type": "progene_text",
"text": [
"IFNA"
],
"offsets": [
[
278,
282
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28745
|
split_0_train_28745
|
[
{
"id": "split_0_train_28745_passage",
"type": "progene_text",
"text": [
"To determine the factors that regulate expression of IRF-7 gene , as well as its inducibility by type I IFNs , we have isolated and characterized the promoter and first intron of the human IRF-7 gene ."
],
"offsets": [
[
0,
201
]
]
}
] |
[
{
"id": "split_0_train_46594_entity",
"type": "progene_text",
"text": [
"IRF-7"
],
"offsets": [
[
53,
58
]
],
"normalized": []
},
{
"id": "split_0_train_46595_entity",
"type": "progene_text",
"text": [
"type I IFNs"
],
"offsets": [
[
97,
108
]
],
"normalized": []
},
{
"id": "split_0_train_46596_entity",
"type": "progene_text",
"text": [
"IRF-7"
],
"offsets": [
[
189,
194
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28746
|
split_0_train_28746
|
[
{
"id": "split_0_train_28746_passage",
"type": "progene_text",
"text": [
"This region shows a presence of two potential interferon - sensitive response elements ( ISRE / IRF-E ) ."
],
"offsets": [
[
0,
105
]
]
}
] |
[
{
"id": "split_0_train_46597_entity",
"type": "progene_text",
"text": [
"interferon"
],
"offsets": [
[
46,
56
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28747
|
split_0_train_28747
|
[
{
"id": "split_0_train_28747_passage",
"type": "progene_text",
"text": [
"However , only the ISRE present in the first intron was functional and conferred interferon inducibility in a transient transfection assay ."
],
"offsets": [
[
0,
140
]
]
}
] |
[
{
"id": "split_0_train_46598_entity",
"type": "progene_text",
"text": [
"interferon"
],
"offsets": [
[
81,
91
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28748
|
split_0_train_28748
|
[
{
"id": "split_0_train_28748_passage",
"type": "progene_text",
"text": [
"Using a pull - down assay with an oligodeoxynucleotide corresponding to this ISRE immobilized to magnetic beads , we have demonstrated that this ISRE binds ISGF3 complex and IRF-1 from the extract of IFN - treated cells but not from the untreated cells ."
],
"offsets": [
[
0,
254
]
]
}
] |
[
{
"id": "split_0_train_46599_entity",
"type": "progene_text",
"text": [
"ISGF3"
],
"offsets": [
[
156,
161
]
],
"normalized": []
},
{
"id": "split_0_train_46600_entity",
"type": "progene_text",
"text": [
"IRF-1"
],
"offsets": [
[
174,
179
]
],
"normalized": []
},
{
"id": "split_0_train_46601_entity",
"type": "progene_text",
"text": [
"IFN"
],
"offsets": [
[
200,
203
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28749
|
split_0_train_28749
|
[
{
"id": "split_0_train_28749_passage",
"type": "progene_text",
"text": [
"We have further shown that the previously observed lack of expression of IRF-7 in 2fTGH fibrosarcoma cell line , correlated with hypermethylation of the CpG island in the human IRF-7 promoter ."
],
"offsets": [
[
0,
193
]
]
}
] |
[
{
"id": "split_0_train_46602_entity",
"type": "progene_text",
"text": [
"IRF-7"
],
"offsets": [
[
73,
78
]
],
"normalized": []
},
{
"id": "split_0_train_46603_entity",
"type": "progene_text",
"text": [
"IRF-7"
],
"offsets": [
[
177,
182
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28750
|
split_0_train_28750
|
[
{
"id": "split_0_train_28750_passage",
"type": "progene_text",
"text": [
"The repression of the promoter activity was relieved by treatment with DNA methyltransferase inhibitor 5-aza-deoxycytidine ."
],
"offsets": [
[
0,
124
]
]
}
] |
[
{
"id": "split_0_train_46604_entity",
"type": "progene_text",
"text": [
"DNA methyltransferase"
],
"offsets": [
[
71,
92
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28751
|
split_0_train_28751
|
[
{
"id": "split_0_train_28751_passage",
"type": "progene_text",
"text": [
"In vitro methylation of IRF-7 promoter silenced IRF-7 directed expression of luciferase gene in HeLa cells that express endogenous IRF-7 gene ."
],
"offsets": [
[
0,
143
]
]
}
] |
[
{
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"text": [
"IRF-7"
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131,
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}
] |
[] |
[] |
[] |
split_0_train_28752
|
split_0_train_28752
|
[
{
"id": "split_0_train_28752_passage",
"type": "progene_text",
"text": [
"Whether silencing of IRF-7 by methylation is instrumental for the process of tumorigenesis remains to be determined ."
],
"offsets": [
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0,
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}
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[
{
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"type": "progene_text",
"text": [
"IRF-7"
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"offsets": [
[
21,
26
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28753
|
split_0_train_28753
|
[
{
"id": "split_0_train_28753_passage",
"type": "progene_text",
"text": [
"A second leukotriene B(4) receptor , BLT2 ."
],
"offsets": [
[
0,
43
]
]
}
] |
[
{
"id": "split_0_train_46610_entity",
"type": "progene_text",
"text": [
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{
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"type": "progene_text",
"text": [
"BLT2"
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"offsets": [
[
37,
41
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28754
|
split_0_train_28754
|
[
{
"id": "split_0_train_28754_passage",
"type": "progene_text",
"text": [
"A new therapeutic target in inflammation and immunological disorders ."
],
"offsets": [
[
0,
70
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28755
|
split_0_train_28755
|
[
{
"id": "split_0_train_28755_passage",
"type": "progene_text",
"text": [
"Leukotriene B(4) ( LTB(4) ) is a potent chemoattractant and activator of both granulocytes and macrophages ."
],
"offsets": [
[
0,
108
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28756
|
split_0_train_28756
|
[
{
"id": "split_0_train_28756_passage",
"type": "progene_text",
"text": [
"The actions of LTB(4) appear to be mediated by a specific G protein - coupled receptor ( GPCR ) BLT1 , originally termed BLT ( Yokomizo , T. , T. Izumi , K. Chang , Y. Takuwa , and T. Shimizu. 1997. Nature. 387 : 620 - 624 ) ."
],
"offsets": [
[
0,
226
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}
] |
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{
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{
"id": "split_0_train_46615_entity",
"type": "progene_text",
"text": [
"BLT"
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"offsets": [
[
121,
124
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28757
|
split_0_train_28757
|
[
{
"id": "split_0_train_28757_passage",
"type": "progene_text",
"text": [
"Here , we report the molecular cloning of a novel GPCR for LTB ( 4 ) , designated BLT2 , which binds LTB ( 4 ) with a Kd value of 23 nM compared with 1.1 nM for BLT1 , but still efficiently transduces intracellular signaling ."
],
"offsets": [
[
0,
226
]
]
}
] |
[
{
"id": "split_0_train_46616_entity",
"type": "progene_text",
"text": [
"GPCR"
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50,
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{
"id": "split_0_train_46617_entity",
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"text": [
"BLT2"
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82,
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{
"id": "split_0_train_46618_entity",
"type": "progene_text",
"text": [
"BLT1"
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"offsets": [
[
161,
165
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28758
|
split_0_train_28758
|
[
{
"id": "split_0_train_28758_passage",
"type": "progene_text",
"text": [
"BLT2 is highly homologous to BLT1 , with an amino acid identity of 45.2 % , and its open reading frame is located in the promoter region of the BLT1 gene ."
],
"offsets": [
[
0,
155
]
]
}
] |
[
{
"id": "split_0_train_46619_entity",
"type": "progene_text",
"text": [
"BLT2"
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0,
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{
"id": "split_0_train_46620_entity",
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"text": [
"BLT1"
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29,
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{
"id": "split_0_train_46621_entity",
"type": "progene_text",
"text": [
"BLT1"
],
"offsets": [
[
144,
148
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28759
|
split_0_train_28759
|
[
{
"id": "split_0_train_28759_passage",
"type": "progene_text",
"text": [
"BLT2 is expressed ubiquitously , in contrast to BLT1 , which is expressed predominantly in leukocytes ."
],
"offsets": [
[
0,
103
]
]
}
] |
[
{
"id": "split_0_train_46622_entity",
"type": "progene_text",
"text": [
"BLT2"
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"offsets": [
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0,
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{
"id": "split_0_train_46623_entity",
"type": "progene_text",
"text": [
"BLT1"
],
"offsets": [
[
48,
52
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28760
|
split_0_train_28760
|
[
{
"id": "split_0_train_28760_passage",
"type": "progene_text",
"text": [
"Chinese hamster ovary cells expressing BLT2 exhibit LTB(4) - induced chemotaxis , calcium mobilization , and pertussis toxin - insensitive inhibition of adenylyl cyclase ."
],
"offsets": [
[
0,
171
]
]
}
] |
[
{
"id": "split_0_train_46624_entity",
"type": "progene_text",
"text": [
"BLT2"
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39,
43
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{
"id": "split_0_train_46625_entity",
"type": "progene_text",
"text": [
"pertussis toxin"
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109,
124
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{
"id": "split_0_train_46626_entity",
"type": "progene_text",
"text": [
"adenylyl cyclase"
],
"offsets": [
[
153,
169
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28761
|
split_0_train_28761
|
[
{
"id": "split_0_train_28761_passage",
"type": "progene_text",
"text": [
"Several BLT1 antagonists , including U 75302 , failed to inhibit LTB ( 4 ) binding to BLT2 ."
],
"offsets": [
[
0,
92
]
]
}
] |
[
{
"id": "split_0_train_46627_entity",
"type": "progene_text",
"text": [
"BLT1"
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"offsets": [
[
8,
12
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],
"normalized": []
},
{
"id": "split_0_train_46628_entity",
"type": "progene_text",
"text": [
"BLT2"
],
"offsets": [
[
86,
90
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28762
|
split_0_train_28762
|
[
{
"id": "split_0_train_28762_passage",
"type": "progene_text",
"text": [
"Thus , BLT2 is a pharmacologically distinct receptor for LTB ( 4 ) , and may mediate cellular functions in tissues other than leukocytes ."
],
"offsets": [
[
0,
138
]
]
}
] |
[
{
"id": "split_0_train_46629_entity",
"type": "progene_text",
"text": [
"BLT2"
],
"offsets": [
[
7,
11
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28763
|
split_0_train_28763
|
[
{
"id": "split_0_train_28763_passage",
"type": "progene_text",
"text": [
"BLT2 provides a novel target for antiinflammatory therapy and promises to expand our knowledge of LTB(4) function ."
],
"offsets": [
[
0,
115
]
]
}
] |
[
{
"id": "split_0_train_46630_entity",
"type": "progene_text",
"text": [
"BLT2"
],
"offsets": [
[
0,
4
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28764
|
split_0_train_28764
|
[
{
"id": "split_0_train_28764_passage",
"type": "progene_text",
"text": [
"The location of the gene suggests shared transcriptional regulation of these two receptors ."
],
"offsets": [
[
0,
92
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28765
|
split_0_train_28765
|
[
{
"id": "split_0_train_28765_passage",
"type": "progene_text",
"text": [
"Genes encoding pseudo - response regulators : insight into His - to - Asp phosphorelay and circadian rhythm in Arabidopsis thaliana ."
],
"offsets": [
[
0,
133
]
]
}
] |
[
{
"id": "split_0_train_46631_entity",
"type": "progene_text",
"text": [
"pseudo - response regulators"
],
"offsets": [
[
15,
43
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28766
|
split_0_train_28766
|
[
{
"id": "split_0_train_28766_passage",
"type": "progene_text",
"text": [
"In the higher plant , Arabidopsis thaliana , results from recent intensive studies suggested that His-to - Asp phosphorelay mechanisms are involved presumably in propagation of environmental stimuli , such as phytohormones ( e.g. ethylene and cytokinin ) ."
],
"offsets": [
[
0,
256
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28767
|
split_0_train_28767
|
[
{
"id": "split_0_train_28767_passage",
"type": "progene_text",
"text": [
"Here we identified and characterized a set of novel Arabidopsis genes whose products considerably resemble the authentic response regulators ( ARR - series ) of Arabidopsis in the sense that they have a phospho - accepting receiver - like domain ."
],
"offsets": [
[
0,
247
]
]
}
] |
[
{
"id": "split_0_train_46632_entity",
"type": "progene_text",
"text": [
"authentic response regulators"
],
"offsets": [
[
111,
140
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],
"normalized": []
},
{
"id": "split_0_train_46633_entity",
"type": "progene_text",
"text": [
"ARR"
],
"offsets": [
[
143,
146
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28768
|
split_0_train_28768
|
[
{
"id": "split_0_train_28768_passage",
"type": "progene_text",
"text": [
"However , they should be discriminated from the classical ones in the strict sense that they lack the invariant phospho - accepting aspartate site ."
],
"offsets": [
[
0,
148
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28769
|
split_0_train_28769
|
[
{
"id": "split_0_train_28769_passage",
"type": "progene_text",
"text": [
"They were thus named APRRs ( Arabidopsis pseudo - response regulators ) ."
],
"offsets": [
[
0,
73
]
]
}
] |
[
{
"id": "split_0_train_46634_entity",
"type": "progene_text",
"text": [
"APRRs"
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"offsets": [
[
21,
26
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],
"normalized": []
},
{
"id": "split_0_train_46635_entity",
"type": "progene_text",
"text": [
"Arabidopsis pseudo - response regulators"
],
"offsets": [
[
29,
69
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28770
|
split_0_train_28770
|
[
{
"id": "split_0_train_28770_passage",
"type": "progene_text",
"text": [
"Two such representatives , APRR1 and APRR2 , were characterized extensively through cloning of the corresponding cDNAs , in terms of their structural designs , biochemical properties , subcellular localization in plant cells , and expression profiles at the transcriptional level ."
],
"offsets": [
[
0,
281
]
]
}
] |
[
{
"id": "split_0_train_46636_entity",
"type": "progene_text",
"text": [
"APRR1"
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"offsets": [
[
27,
32
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],
"normalized": []
},
{
"id": "split_0_train_46637_entity",
"type": "progene_text",
"text": [
"APRR2"
],
"offsets": [
[
37,
42
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28771
|
split_0_train_28771
|
[
{
"id": "split_0_train_28771_passage",
"type": "progene_text",
"text": [
"The result of in vitro phosphorylation experiment with the Arabidopsis AHP phosphotransmitter suggested that the pseudo - receivers have no ability to undergo phosphorylation ."
],
"offsets": [
[
0,
176
]
]
}
] |
[
{
"id": "split_0_train_46638_entity",
"type": "progene_text",
"text": [
"AHP"
],
"offsets": [
[
71,
74
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28772
|
split_0_train_28772
|
[
{
"id": "split_0_train_28772_passage",
"type": "progene_text",
"text": [
"The result of transient expression assay with onion epidermal cells showed that the GFP - APRR1 fusion protein has an ability to enter into the nuclei ."
],
"offsets": [
[
0,
152
]
]
}
] |
[
{
"id": "split_0_train_46639_entity",
"type": "progene_text",
"text": [
"GFP"
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"offsets": [
[
84,
87
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],
"normalized": []
},
{
"id": "split_0_train_46640_entity",
"type": "progene_text",
"text": [
"APRR1"
],
"offsets": [
[
90,
95
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28773
|
split_0_train_28773
|
[
{
"id": "split_0_train_28773_passage",
"type": "progene_text",
"text": [
"The C - terminal domain of APRR1 , termed CONSTANS - motif , appears to be responsible for the nuclear - localization ."
],
"offsets": [
[
0,
119
]
]
}
] |
[
{
"id": "split_0_train_46641_entity",
"type": "progene_text",
"text": [
"APRR1"
],
"offsets": [
[
27,
32
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28774
|
split_0_train_28774
|
[
{
"id": "split_0_train_28774_passage",
"type": "progene_text",
"text": [
"The most intriguing result was that the accumulation of APRR1 transcript is subjected to a circadian rhythm ."
],
"offsets": [
[
0,
109
]
]
}
] |
[
{
"id": "split_0_train_46642_entity",
"type": "progene_text",
"text": [
"APRR1"
],
"offsets": [
[
56,
61
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28775
|
split_0_train_28775
|
[
{
"id": "split_0_train_28775_passage",
"type": "progene_text",
"text": [
"The APRR1 protein is identical to the one that was recently suggested to interact with the ABI3 ( ABISCISIC ACID INSENSITIVE3 ) protein ."
],
"offsets": [
[
0,
137
]
]
}
] |
[
{
"id": "split_0_train_46643_entity",
"type": "progene_text",
"text": [
"APRR1"
],
"offsets": [
[
4,
9
]
],
"normalized": []
},
{
"id": "split_0_train_46644_entity",
"type": "progene_text",
"text": [
"ABI3"
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"offsets": [
[
91,
95
]
],
"normalized": []
},
{
"id": "split_0_train_46645_entity",
"type": "progene_text",
"text": [
"ABISCISIC ACID INSENSITIVE3"
],
"offsets": [
[
98,
125
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28776
|
split_0_train_28776
|
[
{
"id": "split_0_train_28776_passage",
"type": "progene_text",
"text": [
"These are discussed with special reference to the His - to - Asp phosphorelay signal transduction and circadian rhythm in Arabidopsis thaliana ."
],
"offsets": [
[
0,
144
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28777
|
split_0_train_28777
|
[
{
"id": "split_0_train_28777_passage",
"type": "progene_text",
"text": [
"Suppression of FNR - dependent transcription activation at the Escherichia coli nir promoter by Fis , IHF and H-NS : modulation of transcription initiation by a complex nucleo - protein assembly ."
],
"offsets": [
[
0,
196
]
]
}
] |
[
{
"id": "split_0_train_46646_entity",
"type": "progene_text",
"text": [
"FNR"
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"offsets": [
[
15,
18
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],
"normalized": []
},
{
"id": "split_0_train_46647_entity",
"type": "progene_text",
"text": [
"nir"
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"offsets": [
[
80,
83
]
],
"normalized": []
},
{
"id": "split_0_train_46648_entity",
"type": "progene_text",
"text": [
"Fis"
],
"offsets": [
[
96,
99
]
],
"normalized": []
},
{
"id": "split_0_train_46649_entity",
"type": "progene_text",
"text": [
"IHF"
],
"offsets": [
[
102,
105
]
],
"normalized": []
},
{
"id": "split_0_train_46650_entity",
"type": "progene_text",
"text": [
"H-NS"
],
"offsets": [
[
110,
114
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28778
|
split_0_train_28778
|
[
{
"id": "split_0_train_28778_passage",
"type": "progene_text",
"text": [
"Expression from the Escherichia coli nir promoter is co - dependent on both the FNR protein ( an anaerobically triggered transcription activator ) and the NarL or NarP proteins ( transcription activators triggered by nitrite and nitrate ) ."
],
"offsets": [
[
0,
240
]
]
}
] |
[
{
"id": "split_0_train_46651_entity",
"type": "progene_text",
"text": [
"nir"
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"offsets": [
[
37,
40
]
],
"normalized": []
},
{
"id": "split_0_train_46652_entity",
"type": "progene_text",
"text": [
"FNR"
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"offsets": [
[
80,
83
]
],
"normalized": []
},
{
"id": "split_0_train_46653_entity",
"type": "progene_text",
"text": [
"NarL"
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"offsets": [
[
155,
159
]
],
"normalized": []
},
{
"id": "split_0_train_46654_entity",
"type": "progene_text",
"text": [
"NarP"
],
"offsets": [
[
163,
167
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28779
|
split_0_train_28779
|
[
{
"id": "split_0_train_28779_passage",
"type": "progene_text",
"text": [
"Under anaerobic conditions , FNR binds to a site centred between positions - 41 and - 42 , activating transcription of the nir operon ."
],
"offsets": [
[
0,
135
]
]
}
] |
[
{
"id": "split_0_train_46655_entity",
"type": "progene_text",
"text": [
"FNR"
],
"offsets": [
[
29,
32
]
],
"normalized": []
},
{
"id": "split_0_train_46656_entity",
"type": "progene_text",
"text": [
"nir operon"
],
"offsets": [
[
123,
133
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28780
|
split_0_train_28780
|
[
{
"id": "split_0_train_28780_passage",
"type": "progene_text",
"text": [
"In previous work , we showed that this activation is suppressed by the binding of Fis protein , and at least one other protein , to sequence elements located upstream of the nir promoter ."
],
"offsets": [
[
0,
188
]
]
}
] |
[
{
"id": "split_0_train_46657_entity",
"type": "progene_text",
"text": [
"Fis"
],
"offsets": [
[
82,
85
]
],
"normalized": []
},
{
"id": "split_0_train_46658_entity",
"type": "progene_text",
"text": [
"nir"
],
"offsets": [
[
174,
177
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28781
|
split_0_train_28781
|
[
{
"id": "split_0_train_28781_passage",
"type": "progene_text",
"text": [
"We proposed that the binding of NarL or NarP to a site centred between positions - 69 and - 70 counteracts this suppression , resulting in increased transcription in response to nitrite or nitrate ."
],
"offsets": [
[
0,
198
]
]
}
] |
[
{
"id": "split_0_train_46659_entity",
"type": "progene_text",
"text": [
"NarL"
],
"offsets": [
[
32,
36
]
],
"normalized": []
},
{
"id": "split_0_train_46660_entity",
"type": "progene_text",
"text": [
"NarP"
],
"offsets": [
[
40,
44
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28782
|
split_0_train_28782
|
[
{
"id": "split_0_train_28782_passage",
"type": "progene_text",
"text": [
"Here we have further investigated the different proteins that downregulate the nir promoter ."
],
"offsets": [
[
0,
93
]
]
}
] |
[
{
"id": "split_0_train_46661_entity",
"type": "progene_text",
"text": [
"nir"
],
"offsets": [
[
79,
82
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28783
|
split_0_train_28783
|
[
{
"id": "split_0_train_28783_passage",
"type": "progene_text",
"text": [
"We show that the nir promoter is repressed by three DNA binding proteins , Fis , IHF and H-NS ."
],
"offsets": [
[
0,
95
]
]
}
] |
[
{
"id": "split_0_train_46662_entity",
"type": "progene_text",
"text": [
"nir"
],
"offsets": [
[
17,
20
]
],
"normalized": []
},
{
"id": "split_0_train_46663_entity",
"type": "progene_text",
"text": [
"Fis"
],
"offsets": [
[
75,
78
]
],
"normalized": []
},
{
"id": "split_0_train_46664_entity",
"type": "progene_text",
"text": [
"IHF"
],
"offsets": [
[
81,
84
]
],
"normalized": []
},
{
"id": "split_0_train_46665_entity",
"type": "progene_text",
"text": [
"H-NS"
],
"offsets": [
[
89,
93
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28784
|
split_0_train_28784
|
[
{
"id": "split_0_train_28784_passage",
"type": "progene_text",
"text": [
"We demonstrate that , in addition to binding to its previously characterized upstream site located at position - 142 , Fis also binds to a second downstream site located at position + 23 ."
],
"offsets": [
[
0,
188
]
]
}
] |
[
{
"id": "split_0_train_46666_entity",
"type": "progene_text",
"text": [
"Fis"
],
"offsets": [
[
119,
122
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28785
|
split_0_train_28785
|
[
{
"id": "split_0_train_28785_passage",
"type": "progene_text",
"text": [
"A second suppressing factor is IHF , that binds to a site located at position - 88 ."
],
"offsets": [
[
0,
84
]
]
}
] |
[
{
"id": "split_0_train_46667_entity",
"type": "progene_text",
"text": [
"IHF"
],
"offsets": [
[
31,
34
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28786
|
split_0_train_28786
|
[
{
"id": "split_0_train_28786_passage",
"type": "progene_text",
"text": [
"Finally , the nucleoid associated protein , H-NS , preferentially binds to upstream sequences at the nir promoter and represses promoter activity ."
],
"offsets": [
[
0,
147
]
]
}
] |
[
{
"id": "split_0_train_46668_entity",
"type": "progene_text",
"text": [
"H-NS"
],
"offsets": [
[
44,
48
]
],
"normalized": []
},
{
"id": "split_0_train_46669_entity",
"type": "progene_text",
"text": [
"nir"
],
"offsets": [
[
101,
104
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28787
|
split_0_train_28787
|
[
{
"id": "split_0_train_28787_passage",
"type": "progene_text",
"text": [
"The association of Fis , IHF and H-NS suggests that nir promoter DNA is sequestrated into a highly ordered nucleo - protein structure that represses FNR - dependent transcription activation ."
],
"offsets": [
[
0,
191
]
]
}
] |
[
{
"id": "split_0_train_46670_entity",
"type": "progene_text",
"text": [
"Fis"
],
"offsets": [
[
19,
22
]
],
"normalized": []
},
{
"id": "split_0_train_46671_entity",
"type": "progene_text",
"text": [
"IHF"
],
"offsets": [
[
25,
28
]
],
"normalized": []
},
{
"id": "split_0_train_46672_entity",
"type": "progene_text",
"text": [
"H-NS"
],
"offsets": [
[
33,
37
]
],
"normalized": []
},
{
"id": "split_0_train_46673_entity",
"type": "progene_text",
"text": [
"nir"
],
"offsets": [
[
52,
55
]
],
"normalized": []
},
{
"id": "split_0_train_46674_entity",
"type": "progene_text",
"text": [
"FNR"
],
"offsets": [
[
149,
152
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28788
|
split_0_train_28788
|
[
{
"id": "split_0_train_28788_passage",
"type": "progene_text",
"text": [
"NarL and NarP can relieve both IHF - and Fis - mediated repression , but are unable to counteract H-NS - mediated repression ."
],
"offsets": [
[
0,
126
]
]
}
] |
[
{
"id": "split_0_train_46675_entity",
"type": "progene_text",
"text": [
"NarL"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_46676_entity",
"type": "progene_text",
"text": [
"NarP"
],
"offsets": [
[
9,
13
]
],
"normalized": []
},
{
"id": "split_0_train_46677_entity",
"type": "progene_text",
"text": [
"IHF"
],
"offsets": [
[
31,
34
]
],
"normalized": []
},
{
"id": "split_0_train_46678_entity",
"type": "progene_text",
"text": [
"Fis"
],
"offsets": [
[
41,
44
]
],
"normalized": []
},
{
"id": "split_0_train_46679_entity",
"type": "progene_text",
"text": [
"H-NS"
],
"offsets": [
[
98,
102
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28789
|
split_0_train_28789
|
[
{
"id": "split_0_train_28789_passage",
"type": "progene_text",
"text": [
"Tor - mediated induction of autophagy via an Apg1 protein kinase complex ."
],
"offsets": [
[
0,
74
]
]
}
] |
[
{
"id": "split_0_train_46680_entity",
"type": "progene_text",
"text": [
"Tor"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "split_0_train_46681_entity",
"type": "progene_text",
"text": [
"Apg1"
],
"offsets": [
[
45,
49
]
],
"normalized": []
},
{
"id": "split_0_train_46682_entity",
"type": "progene_text",
"text": [
"protein kinase"
],
"offsets": [
[
50,
64
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28790
|
split_0_train_28790
|
[
{
"id": "split_0_train_28790_passage",
"type": "progene_text",
"text": [
"Autophagy is a membrane trafficking to vacuole / lysosome induced by nutrient starvation ."
],
"offsets": [
[
0,
90
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28791
|
split_0_train_28791
|
[
{
"id": "split_0_train_28791_passage",
"type": "progene_text",
"text": [
"In Saccharomyces cerevisiae , Tor protein , a phosphatidylinositol kinase - related kinase , is involved in the repression of autophagy induction by a largely unknown mechanism ."
],
"offsets": [
[
0,
178
]
]
}
] |
[
{
"id": "split_0_train_46683_entity",
"type": "progene_text",
"text": [
"Tor"
],
"offsets": [
[
30,
33
]
],
"normalized": []
},
{
"id": "split_0_train_46684_entity",
"type": "progene_text",
"text": [
"phosphatidylinositol kinase"
],
"offsets": [
[
46,
73
]
],
"normalized": []
},
{
"id": "split_0_train_46685_entity",
"type": "progene_text",
"text": [
"kinase"
],
"offsets": [
[
84,
90
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28792
|
split_0_train_28792
|
[
{
"id": "split_0_train_28792_passage",
"type": "progene_text",
"text": [
"Here , we show that the protein kinase activity of Apg1 is enhanced by starvation or rapamycin treatment ."
],
"offsets": [
[
0,
106
]
]
}
] |
[
{
"id": "split_0_train_46686_entity",
"type": "progene_text",
"text": [
"protein kinase"
],
"offsets": [
[
24,
38
]
],
"normalized": []
},
{
"id": "split_0_train_46687_entity",
"type": "progene_text",
"text": [
"Apg1"
],
"offsets": [
[
51,
55
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28793
|
split_0_train_28793
|
[
{
"id": "split_0_train_28793_passage",
"type": "progene_text",
"text": [
"In addition , we have also found that Apg13 , which binds to and activates Apg1 , is hyperphosphorylated in a Tor - dependent manner , reducing its affinity to Apg1 ."
],
"offsets": [
[
0,
166
]
]
}
] |
[
{
"id": "split_0_train_46688_entity",
"type": "progene_text",
"text": [
"Apg13"
],
"offsets": [
[
38,
43
]
],
"normalized": []
},
{
"id": "split_0_train_46689_entity",
"type": "progene_text",
"text": [
"Apg1"
],
"offsets": [
[
75,
79
]
],
"normalized": []
},
{
"id": "split_0_train_46690_entity",
"type": "progene_text",
"text": [
"Tor"
],
"offsets": [
[
110,
113
]
],
"normalized": []
},
{
"id": "split_0_train_46691_entity",
"type": "progene_text",
"text": [
"Apg1"
],
"offsets": [
[
160,
164
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28794
|
split_0_train_28794
|
[
{
"id": "split_0_train_28794_passage",
"type": "progene_text",
"text": [
"This Apg1 - Apg13 association is required for autophagy , but not for the cytoplasm - to - vacuole targeting ( Cvt ) pathway , another vesicular transport mechanism in which factors essential for autophagy ( Apg proteins ) are also employed under vegetative growth conditions ."
],
"offsets": [
[
0,
277
]
]
}
] |
[
{
"id": "split_0_train_46692_entity",
"type": "progene_text",
"text": [
"Apg1"
],
"offsets": [
[
5,
9
]
],
"normalized": []
},
{
"id": "split_0_train_46693_entity",
"type": "progene_text",
"text": [
"Apg13"
],
"offsets": [
[
12,
17
]
],
"normalized": []
},
{
"id": "split_0_train_46694_entity",
"type": "progene_text",
"text": [
"Apg"
],
"offsets": [
[
208,
211
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28795
|
split_0_train_28795
|
[
{
"id": "split_0_train_28795_passage",
"type": "progene_text",
"text": [
"Finally , other Apg1 - associating proteins , such as Apg17 and Cvt9 , are shown to function specifically in autophagy or the Cvt pathway , respectively , suggesting that the Apg1 complex plays an important role in switching between two distinct vesicular transport systems in a nutrient - dependent manner ."
],
"offsets": [
[
0,
308
]
]
}
] |
[
{
"id": "split_0_train_46695_entity",
"type": "progene_text",
"text": [
"Apg1"
],
"offsets": [
[
16,
20
]
],
"normalized": []
},
{
"id": "split_0_train_46696_entity",
"type": "progene_text",
"text": [
"Apg17"
],
"offsets": [
[
54,
59
]
],
"normalized": []
},
{
"id": "split_0_train_46697_entity",
"type": "progene_text",
"text": [
"Cvt9"
],
"offsets": [
[
64,
68
]
],
"normalized": []
},
{
"id": "split_0_train_46698_entity",
"type": "progene_text",
"text": [
"Apg1"
],
"offsets": [
[
175,
179
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28796
|
split_0_train_28796
|
[
{
"id": "split_0_train_28796_passage",
"type": "progene_text",
"text": [
"Synthesis and characterization of the spore proteins of Bacillus subtilis YdhD , YkuD , and YkvP , which carry a motif conserved among cell wall binding proteins ."
],
"offsets": [
[
0,
163
]
]
}
] |
[
{
"id": "split_0_train_46699_entity",
"type": "progene_text",
"text": [
"YdhD"
],
"offsets": [
[
74,
78
]
],
"normalized": []
},
{
"id": "split_0_train_46700_entity",
"type": "progene_text",
"text": [
"YkuD"
],
"offsets": [
[
81,
85
]
],
"normalized": []
},
{
"id": "split_0_train_46701_entity",
"type": "progene_text",
"text": [
"YkvP"
],
"offsets": [
[
92,
96
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28797
|
split_0_train_28797
|
[
{
"id": "split_0_train_28797_passage",
"type": "progene_text",
"text": [
"We have previously reported that YaaH and YrbA are spore proteins of Bacillus subtilis that are required for spore resistance and/or germination and that they have a motif conserved among so - called cell wall binding proteins [ Kodama et al. ( 1999 ) J. Bacteriol. 181 , 4584 - 4591 , Takamatsu et al. ( 1999 ) J. Bacteriol. 181 , 4986 - 4994 ] ."
],
"offsets": [
[
0,
347
]
]
}
] |
[
{
"id": "split_0_train_46702_entity",
"type": "progene_text",
"text": [
"YaaH"
],
"offsets": [
[
33,
37
]
],
"normalized": []
},
{
"id": "split_0_train_46703_entity",
"type": "progene_text",
"text": [
"YrbA"
],
"offsets": [
[
42,
46
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28798
|
split_0_train_28798
|
[
{
"id": "split_0_train_28798_passage",
"type": "progene_text",
"text": [
"In this study , we analyzed the expression of ydhD , ykuD , and ykvP genes , which encode putative proteins containing the same motif ."
],
"offsets": [
[
0,
135
]
]
}
] |
[
{
"id": "split_0_train_46704_entity",
"type": "progene_text",
"text": [
"ydhD"
],
"offsets": [
[
46,
50
]
],
"normalized": []
},
{
"id": "split_0_train_46705_entity",
"type": "progene_text",
"text": [
"ykuD"
],
"offsets": [
[
53,
57
]
],
"normalized": []
},
{
"id": "split_0_train_46706_entity",
"type": "progene_text",
"text": [
"ykvP"
],
"offsets": [
[
64,
68
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28799
|
split_0_train_28799
|
[
{
"id": "split_0_train_28799_passage",
"type": "progene_text",
"text": [
"Transcription of ydhD was dependent on SigE , and the mRNA was detectable from 2 h after the cessation of logarithmic growth ( T(2) of sporulation ) ."
],
"offsets": [
[
0,
150
]
]
}
] |
[
{
"id": "split_0_train_46707_entity",
"type": "progene_text",
"text": [
"ydhD"
],
"offsets": [
[
17,
21
]
],
"normalized": []
},
{
"id": "split_0_train_46708_entity",
"type": "progene_text",
"text": [
"SigE"
],
"offsets": [
[
39,
43
]
],
"normalized": []
}
] |
[] |
[] |
[] |
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