id
stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
split_0_train_27900
|
split_0_train_27900
|
[
{
"id": "split_0_train_27900_passage",
"type": "progene_text",
"text": [
"Based on the percentages of recovery , the amounts of fecal debris in the final oocyst preparations , the relatively short processing time ( < 3 h ) , and the low expense , the NaCl flotation method was chosen for further evaluation ."
],
"offsets": [
[
0,
234
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27901
|
split_0_train_27901
|
[
{
"id": "split_0_train_27901_passage",
"type": "progene_text",
"text": [
"Extraction efficiency was evaluated by using oocyst concentrations of 25 , 50 , 10 ( 2 ) , 10(3) , 10(4) , and 10 ( 5 ) oocysts g of bovine feces-1 ."
],
"offsets": [
[
0,
149
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27902
|
split_0_train_27902
|
[
{
"id": "split_0_train_27902_passage",
"type": "progene_text",
"text": [
"The percentages of recovery ranged from 10.8 % ( 25 oocysts g-1 ) to 17.0 % ( 10 ( 4 ) oocysts g-1 ) ( r2 = 0.996 ) ."
],
"offsets": [
[
0,
117
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27903
|
split_0_train_27903
|
[
{
"id": "split_0_train_27903_passage",
"type": "progene_text",
"text": [
"A conservative estimate of the detection limit for bovine feces is ca. 30 oocysts g of feces-1 ."
],
"offsets": [
[
0,
96
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27904
|
split_0_train_27904
|
[
{
"id": "split_0_train_27904_passage",
"type": "progene_text",
"text": [
"Percentages of recovery were determined for six different types of animal feces ( cow , horse , pig , sheep , deer , and chicken feces ) at a single oocyst concentration ( 10(4) oocysts g-1) ."
],
"offsets": [
[
0,
192
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27905
|
split_0_train_27905
|
[
{
"id": "split_0_train_27905_passage",
"type": "progene_text",
"text": [
"The percentages of recovery were highest for bovine feces ( 17. 0 % ) and lowest for chicken feces ( 3.2 % ) ."
],
"offsets": [
[
0,
110
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27906
|
split_0_train_27906
|
[
{
"id": "split_0_train_27906_passage",
"type": "progene_text",
"text": [
"Percentages of recovery were determined for bovine manure after 3 to 7 days of storage ."
],
"offsets": [
[
0,
88
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27907
|
split_0_train_27907
|
[
{
"id": "split_0_train_27907_passage",
"type": "progene_text",
"text": [
"The percentages of recovery ranged from 1.9 to 3.5 % depending on the oocyst concentration , the time of storage , and the dispersing solution ."
],
"offsets": [
[
0,
144
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27908
|
split_0_train_27908
|
[
{
"id": "split_0_train_27908_passage",
"type": "progene_text",
"text": [
"The percentages of oocyst recovery from soils were evaluated by using different flotation solutions ( NaCl , cold sucrose , ZnSO4 ) , different dispersing solutions ( Triton X-100 , Tween 80 , Tris plus Tween 80 ) , different dispersion techniques ( magnetic stirring , sonication , blending ) , and different dispersion times ( 5 , 15 , and 30 min ) ."
],
"offsets": [
[
0,
352
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27909
|
split_0_train_27909
|
[
{
"id": "split_0_train_27909_passage",
"type": "progene_text",
"text": [
"Twenty-five - gram soil samples were used to reduce the spatial variability ."
],
"offsets": [
[
0,
77
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27910
|
split_0_train_27910
|
[
{
"id": "split_0_train_27910_passage",
"type": "progene_text",
"text": [
"The highest percentages of recovery were obtained when we used 50 mM Tris - 0.5 % Tween 80 as the dispersing solution , dispersion for 15 min by stirring , and saturated NaCl as the flotation solution ."
],
"offsets": [
[
0,
202
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27911
|
split_0_train_27911
|
[
{
"id": "split_0_train_27911_passage",
"type": "progene_text",
"text": [
"The percentages of oocyst recovery from freshly spiked sandy loam , silty clay loam , and clay loam soils were ca. 12 to 18 , 8 , and 6 % , respectively ."
],
"offsets": [
[
0,
154
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27912
|
split_0_train_27912
|
[
{
"id": "split_0_train_27912_passage",
"type": "progene_text",
"text": [
"The theoretical detection limits were ca. 1 to 2 oocysts g of soil-1 depending on the soil type ."
],
"offsets": [
[
0,
97
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27913
|
split_0_train_27913
|
[
{
"id": "split_0_train_27913_passage",
"type": "progene_text",
"text": [
"The percentages of recovery without dispersant ( distilled H2O or phosphate - buffered saline ) were less than 0.1 % , which indicated that oocysts adhere to soil particles ."
],
"offsets": [
[
0,
174
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27914
|
split_0_train_27914
|
[
{
"id": "split_0_train_27914_passage",
"type": "progene_text",
"text": [
"The percentages of recovery decreased with storage time , although the addition of dispersant ( Tris-Tween 80 ) before storage appeared to partially prevent adhesion ."
],
"offsets": [
[
0,
167
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27915
|
split_0_train_27915
|
[
{
"id": "split_0_train_27915_passage",
"type": "progene_text",
"text": [
"These data indicate that the NaCl flotation method is suitable for routine detection and enumeration of oocysts from feces , manures , soils , or soil - manure mixtures ."
],
"offsets": [
[
0,
170
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27916
|
split_0_train_27916
|
[
{
"id": "split_0_train_27916_passage",
"type": "progene_text",
"text": [
"Commitment and differentiation of lung cell lineages ."
],
"offsets": [
[
0,
54
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27917
|
split_0_train_27917
|
[
{
"id": "split_0_train_27917_passage",
"type": "progene_text",
"text": [
"To form a large diffusible interface capable of conducting respiratory gases to and from the circulation , the lung must undergo extensive cell proliferation , branching morphogenesis , and alveolar saccule formation , to generate sufficient surface area ."
],
"offsets": [
[
0,
256
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27918
|
split_0_train_27918
|
[
{
"id": "split_0_train_27918_passage",
"type": "progene_text",
"text": [
"In addition , the cells must differentiate into at least 40 distinct lung cell lineages ."
],
"offsets": [
[
0,
89
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27919
|
split_0_train_27919
|
[
{
"id": "split_0_train_27919_passage",
"type": "progene_text",
"text": [
"Specific transcriptional factors , peptide growth factor receptor - mediated signaling pathways , extracellular matrix components , and integrin - signaling pathways interact to direct lung morphogenesis and lung cell lineage differentiation ."
],
"offsets": [
[
0,
243
]
]
}
] |
[
{
"id": "split_0_train_45132_entity",
"type": "progene_text",
"text": [
"transcriptional factors"
],
"offsets": [
[
9,
32
]
],
"normalized": []
},
{
"id": "split_0_train_45133_entity",
"type": "progene_text",
"text": [
"peptide growth factor receptor"
],
"offsets": [
[
35,
65
]
],
"normalized": []
},
{
"id": "split_0_train_45134_entity",
"type": "progene_text",
"text": [
"integrin"
],
"offsets": [
[
136,
144
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27920
|
split_0_train_27920
|
[
{
"id": "split_0_train_27920_passage",
"type": "progene_text",
"text": [
"Branching mutants of the respiratory tracheae in Drosophila have identified several functionally conserved genes in the fibroblast growth factor signaling pathway that also regulate pulmonary organogenesis in mice and probably also in man ."
],
"offsets": [
[
0,
240
]
]
}
] |
[
{
"id": "split_0_train_45135_entity",
"type": "progene_text",
"text": [
"fibroblast growth factor"
],
"offsets": [
[
120,
144
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27921
|
split_0_train_27921
|
[
{
"id": "split_0_train_27921_passage",
"type": "progene_text",
"text": [
"Key transcriptional factors including Nkx2.1 , hepatocyte nuclear factor family forkhead homologues , GATA family zinc finger factors , pou and homeodomain proteins , as well as basic helix - loop - helix factors , serve as master genes to integrate the developmental genetic instruction of lung morphogenesis and cell lineage determination ."
],
"offsets": [
[
0,
342
]
]
}
] |
[
{
"id": "split_0_train_45136_entity",
"type": "progene_text",
"text": [
"transcriptional factors"
],
"offsets": [
[
4,
27
]
],
"normalized": []
},
{
"id": "split_0_train_45137_entity",
"type": "progene_text",
"text": [
"Nkx2.1"
],
"offsets": [
[
38,
44
]
],
"normalized": []
},
{
"id": "split_0_train_45138_entity",
"type": "progene_text",
"text": [
"hepatocyte nuclear factor family forkhead homologues"
],
"offsets": [
[
47,
99
]
],
"normalized": []
},
{
"id": "split_0_train_45139_entity",
"type": "progene_text",
"text": [
"GATA family zinc finger factors"
],
"offsets": [
[
102,
133
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27922
|
split_0_train_27922
|
[
{
"id": "split_0_train_27922_passage",
"type": "progene_text",
"text": [
"Lung mesenchyme serves as a ' compleat ' inducer of lung morphogenesis by secreting soluble peptide growth factors ."
],
"offsets": [
[
0,
116
]
]
}
] |
[
{
"id": "split_0_train_45140_entity",
"type": "progene_text",
"text": [
"peptide growth factors"
],
"offsets": [
[
92,
114
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27923
|
split_0_train_27923
|
[
{
"id": "split_0_train_27923_passage",
"type": "progene_text",
"text": [
"In general , peptide growth factors signaling through cognate receptors with tyrosine kinase intracellular signaling domains such as epidermal growth factor receptor , fibroblast growth factor receptors , hepatocyte growth factor / scatter factor receptor , c-met , insulin - like growth factor receptor , and platelet - derived growth factor receptor , stimulate lung morphogenesis , while the cognate receptors with serine / threonine kinase intracellular signaling domains , such as the transforming growth factor - beta receptor family are inhibitory ."
],
"offsets": [
[
0,
556
]
]
}
] |
[
{
"id": "split_0_train_45141_entity",
"type": "progene_text",
"text": [
"peptide growth factors"
],
"offsets": [
[
13,
35
]
],
"normalized": []
},
{
"id": "split_0_train_45142_entity",
"type": "progene_text",
"text": [
"tyrosine kinase"
],
"offsets": [
[
77,
92
]
],
"normalized": []
},
{
"id": "split_0_train_45143_entity",
"type": "progene_text",
"text": [
"epidermal growth factor receptor"
],
"offsets": [
[
133,
165
]
],
"normalized": []
},
{
"id": "split_0_train_45144_entity",
"type": "progene_text",
"text": [
"fibroblast growth factor receptors"
],
"offsets": [
[
168,
202
]
],
"normalized": []
},
{
"id": "split_0_train_45145_entity",
"type": "progene_text",
"text": [
"hepatocyte growth factor"
],
"offsets": [
[
205,
229
]
],
"normalized": []
},
{
"id": "split_0_train_45146_entity",
"type": "progene_text",
"text": [
"scatter factor receptor"
],
"offsets": [
[
232,
255
]
],
"normalized": []
},
{
"id": "split_0_train_45147_entity",
"type": "progene_text",
"text": [
"c-met"
],
"offsets": [
[
258,
263
]
],
"normalized": []
},
{
"id": "split_0_train_45148_entity",
"type": "progene_text",
"text": [
"insulin - like growth factor receptor"
],
"offsets": [
[
266,
303
]
],
"normalized": []
},
{
"id": "split_0_train_45149_entity",
"type": "progene_text",
"text": [
"platelet - derived growth factor receptor"
],
"offsets": [
[
310,
351
]
],
"normalized": []
},
{
"id": "split_0_train_45150_entity",
"type": "progene_text",
"text": [
"serine / threonine kinase"
],
"offsets": [
[
418,
443
]
],
"normalized": []
},
{
"id": "split_0_train_45151_entity",
"type": "progene_text",
"text": [
"transforming growth factor - beta receptor family"
],
"offsets": [
[
490,
539
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27924
|
split_0_train_27924
|
[
{
"id": "split_0_train_27924_passage",
"type": "progene_text",
"text": [
"The extracellular matrix also plays a key role in determining branching morphogenesis ."
],
"offsets": [
[
0,
87
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27925
|
split_0_train_27925
|
[
{
"id": "split_0_train_27925_passage",
"type": "progene_text",
"text": [
"Pulmonary neuroendocrine ( PNE ) cells differentiate earliest in gestation among lung epithelial cells ."
],
"offsets": [
[
0,
104
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27926
|
split_0_train_27926
|
[
{
"id": "split_0_train_27926_passage",
"type": "progene_text",
"text": [
"PNE cells are principally derived from endoderm and not neural crest ."
],
"offsets": [
[
0,
70
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27927
|
split_0_train_27927
|
[
{
"id": "split_0_train_27927_passage",
"type": "progene_text",
"text": [
"PNE cells have been proposed to function as airway chemoreceptors , while PNE cell secretory granules contain many bioactive substances such as GRP which may direct proliferation of adjacent epithelial cells ."
],
"offsets": [
[
0,
209
]
]
}
] |
[
{
"id": "split_0_train_45152_entity",
"type": "progene_text",
"text": [
"chemoreceptors"
],
"offsets": [
[
51,
65
]
],
"normalized": []
},
{
"id": "split_0_train_45153_entity",
"type": "progene_text",
"text": [
"GRP"
],
"offsets": [
[
144,
147
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27928
|
split_0_train_27928
|
[
{
"id": "split_0_train_27928_passage",
"type": "progene_text",
"text": [
"Mammalian achaete - schute homolog-1 null mutant mice do not develop PNE cells ."
],
"offsets": [
[
0,
80
]
]
}
] |
[
{
"id": "split_0_train_45154_entity",
"type": "progene_text",
"text": [
"achaete - schute homolog-1"
],
"offsets": [
[
10,
36
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27929
|
split_0_train_27929
|
[
{
"id": "split_0_train_27929_passage",
"type": "progene_text",
"text": [
"Candidate molecular switches in the transition from a quiescent to a proliferative alveolar epithelial cell ( AEC ) phenotype and back again following acute hyperoxia , include autocrine peptide growth factor signaling pathways and cell cycle regulatory elements ."
],
"offsets": [
[
0,
264
]
]
}
] |
[
{
"id": "split_0_train_45155_entity",
"type": "progene_text",
"text": [
"peptide growth factor"
],
"offsets": [
[
187,
208
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27930
|
split_0_train_27930
|
[
{
"id": "split_0_train_27930_passage",
"type": "progene_text",
"text": [
"AEC type 2 also appear capable of reversible transdifferentiation into AEC type 1 and intermediate phenotypes in response to cues from extracellular matrix and cell shape , as well as soluble factors ."
],
"offsets": [
[
0,
201
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27931
|
split_0_train_27931
|
[
{
"id": "split_0_train_27931_passage",
"type": "progene_text",
"text": [
"Evidence for expression of telomerase by alveolar epithelial stem cells , which correlates with self - renewal potential , is now beginning to emerge ."
],
"offsets": [
[
0,
151
]
]
}
] |
[
{
"id": "split_0_train_45156_entity",
"type": "progene_text",
"text": [
"telomerase"
],
"offsets": [
[
27,
37
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27932
|
split_0_train_27932
|
[
{
"id": "split_0_train_27932_passage",
"type": "progene_text",
"text": [
"Lung regeneration following lobectomy in juvenile rodents is associated with co - ordinated cell proliferation , re - expression of elastin and formation of alveoli ."
],
"offsets": [
[
0,
166
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27933
|
split_0_train_27933
|
[
{
"id": "split_0_train_27933_passage",
"type": "progene_text",
"text": [
"Retinoic acid has recently shown promise as a stimulator of alveolization in juvenile rats.Our future goal is to devise new rational and gene therapeutic strategies to stimulating lung growth and maturation , ameliorating lung injury , augmenting lung repair , and inducing lung regeneration ."
],
"offsets": [
[
0,
293
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27934
|
split_0_train_27934
|
[
{
"id": "split_0_train_27934_passage",
"type": "progene_text",
"text": [
"The ideal agent or agents would therefore mimic the instructive role of lung mesenchyme , correctly inducing the temporospatial pattern of lung cell lineages necessary to restore pulmonary gas diffusing capacity ."
],
"offsets": [
[
0,
213
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27935
|
split_0_train_27935
|
[
{
"id": "split_0_train_27935_passage",
"type": "progene_text",
"text": [
"Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix ."
],
"offsets": [
[
0,
121
]
]
}
] |
[
{
"id": "split_0_train_45157_entity",
"type": "progene_text",
"text": [
"presenilin 1"
],
"offsets": [
[
11,
23
]
],
"normalized": []
},
{
"id": "split_0_train_45158_entity",
"type": "progene_text",
"text": [
"collagen"
],
"offsets": [
[
104,
112
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27936
|
split_0_train_27936
|
[
{
"id": "split_0_train_27936_passage",
"type": "progene_text",
"text": [
"Most familial early - onset Alzheimer 's disease cases are caused by mutations in the presenilin 1 ( PS1 ) gene ."
],
"offsets": [
[
0,
113
]
]
}
] |
[
{
"id": "split_0_train_45159_entity",
"type": "progene_text",
"text": [
"presenilin 1"
],
"offsets": [
[
86,
98
]
],
"normalized": []
},
{
"id": "split_0_train_45160_entity",
"type": "progene_text",
"text": [
"PS1"
],
"offsets": [
[
101,
104
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27937
|
split_0_train_27937
|
[
{
"id": "split_0_train_27937_passage",
"type": "progene_text",
"text": [
"Subcellular localization of the endogenous PS1 is essential for understanding its function , interactions with proteins , and role in Alzheimer 's disease ."
],
"offsets": [
[
0,
156
]
]
}
] |
[
{
"id": "split_0_train_45161_entity",
"type": "progene_text",
"text": [
"PS1"
],
"offsets": [
[
43,
46
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27938
|
split_0_train_27938
|
[
{
"id": "split_0_train_27938_passage",
"type": "progene_text",
"text": [
"Although numerous studies revealed predominant localization of PS1 to endoplasmic reticulum and Golgi , there are conflicting reports on the localization of PS1 to the cell surface ."
],
"offsets": [
[
0,
182
]
]
}
] |
[
{
"id": "split_0_train_45162_entity",
"type": "progene_text",
"text": [
"PS1"
],
"offsets": [
[
63,
66
]
],
"normalized": []
},
{
"id": "split_0_train_45163_entity",
"type": "progene_text",
"text": [
"PS1"
],
"offsets": [
[
157,
160
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27939
|
split_0_train_27939
|
[
{
"id": "split_0_train_27939_passage",
"type": "progene_text",
"text": [
"We found that endogenous PS1 is highly expressed in T lymphocytes ( Jurkat cells ) ."
],
"offsets": [
[
0,
84
]
]
}
] |
[
{
"id": "split_0_train_45164_entity",
"type": "progene_text",
"text": [
"PS1"
],
"offsets": [
[
25,
28
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27940
|
split_0_train_27940
|
[
{
"id": "split_0_train_27940_passage",
"type": "progene_text",
"text": [
"Using a variety of methods , we present evidence that endogenous PS1 is localized to the cell surface in addition to intracellular membrane compartments ."
],
"offsets": [
[
0,
154
]
]
}
] |
[
{
"id": "split_0_train_45165_entity",
"type": "progene_text",
"text": [
"PS1"
],
"offsets": [
[
65,
68
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27941
|
split_0_train_27941
|
[
{
"id": "split_0_train_27941_passage",
"type": "progene_text",
"text": [
"Moreover , PS1 appeared in high levels on the surface of lamellipodia upon adhesion of the cells to a collagen matrix ."
],
"offsets": [
[
0,
119
]
]
}
] |
[
{
"id": "split_0_train_45166_entity",
"type": "progene_text",
"text": [
"PS1"
],
"offsets": [
[
11,
14
]
],
"normalized": []
},
{
"id": "split_0_train_45167_entity",
"type": "progene_text",
"text": [
"collagen"
],
"offsets": [
[
102,
110
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27942
|
split_0_train_27942
|
[
{
"id": "split_0_train_27942_passage",
"type": "progene_text",
"text": [
"The redistribution of PS1 in adhered cells was strikingly similar to that of the well characterized adhesion protein CD44 ."
],
"offsets": [
[
0,
123
]
]
}
] |
[
{
"id": "split_0_train_45168_entity",
"type": "progene_text",
"text": [
"PS1"
],
"offsets": [
[
22,
25
]
],
"normalized": []
},
{
"id": "split_0_train_45169_entity",
"type": "progene_text",
"text": [
"adhesion protein"
],
"offsets": [
[
100,
116
]
],
"normalized": []
},
{
"id": "split_0_train_45170_entity",
"type": "progene_text",
"text": [
"CD44"
],
"offsets": [
[
117,
121
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27943
|
split_0_train_27943
|
[
{
"id": "split_0_train_27943_passage",
"type": "progene_text",
"text": [
"Cell surface PS1 formed complexes in vivo with actin - binding protein filamin ( ABP-280 ) , which is known to form bridges between cell surface receptors and cytoskeleton and mediate cell adhesion and cell motility ."
],
"offsets": [
[
0,
217
]
]
}
] |
[
{
"id": "split_0_train_45171_entity",
"type": "progene_text",
"text": [
"PS1"
],
"offsets": [
[
13,
16
]
],
"normalized": []
},
{
"id": "split_0_train_45172_entity",
"type": "progene_text",
"text": [
"actin - binding protein"
],
"offsets": [
[
47,
70
]
],
"normalized": []
},
{
"id": "split_0_train_45173_entity",
"type": "progene_text",
"text": [
"filamin"
],
"offsets": [
[
71,
78
]
],
"normalized": []
},
{
"id": "split_0_train_45174_entity",
"type": "progene_text",
"text": [
"ABP-280"
],
"offsets": [
[
81,
88
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27944
|
split_0_train_27944
|
[
{
"id": "split_0_train_27944_passage",
"type": "progene_text",
"text": [
"Taken together , our results suggest a role of PS1 in cell adhesion and/or cell - matrix interaction ."
],
"offsets": [
[
0,
102
]
]
}
] |
[
{
"id": "split_0_train_45175_entity",
"type": "progene_text",
"text": [
"PS1"
],
"offsets": [
[
47,
50
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27945
|
split_0_train_27945
|
[
{
"id": "split_0_train_27945_passage",
"type": "progene_text",
"text": [
"Transcriptional regulatory sequences within the first intron of the chicken apolipoproteinAI ( apoAI ) gene ."
],
"offsets": [
[
0,
109
]
]
}
] |
[
{
"id": "split_0_train_45176_entity",
"type": "progene_text",
"text": [
"apolipoproteinAI"
],
"offsets": [
[
76,
92
]
],
"normalized": []
},
{
"id": "split_0_train_45177_entity",
"type": "progene_text",
"text": [
"apoAI"
],
"offsets": [
[
95,
100
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27946
|
split_0_train_27946
|
[
{
"id": "split_0_train_27946_passage",
"type": "progene_text",
"text": [
"Previous studies demonstrated that the - 82 to + 87 nucleotides ( nt ) 5' - upstream region of the chicken apolipoprotein ( apoAI ) gene are necessary for maximum reporter chloramphenicol acetyl transferase ( cat ) gene activation in chicken hepatocarcinoma ( LMH ) cells [ Bhattacharyya , N. , Chattapadhyay , R. , Oddoux , C. , Banerjee , D. , 1993. Characterisation of the chicken apolipoprotein A-I gene 5' - flanking region. DNA Cell Biol. 12 , 597-604 ] ."
],
"offsets": [
[
0,
461
]
]
}
] |
[
{
"id": "split_0_train_45178_entity",
"type": "progene_text",
"text": [
"apolipoprotein"
],
"offsets": [
[
107,
121
]
],
"normalized": []
},
{
"id": "split_0_train_45179_entity",
"type": "progene_text",
"text": [
"apoAI"
],
"offsets": [
[
124,
129
]
],
"normalized": []
},
{
"id": "split_0_train_45180_entity",
"type": "progene_text",
"text": [
"chloramphenicol acetyl transferase"
],
"offsets": [
[
172,
206
]
],
"normalized": []
},
{
"id": "split_0_train_45181_entity",
"type": "progene_text",
"text": [
"cat"
],
"offsets": [
[
209,
212
]
],
"normalized": []
},
{
"id": "split_0_train_45182_entity",
"type": "progene_text",
"text": [
"apolipoprotein A-I"
],
"offsets": [
[
384,
402
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27947
|
split_0_train_27947
|
[
{
"id": "split_0_train_27947_passage",
"type": "progene_text",
"text": [
"The - 82 to + 87nt contain the 5' - untranslated nt , part of the first intron , and the upstream regulatory sequences ."
],
"offsets": [
[
0,
120
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27948
|
split_0_train_27948
|
[
{
"id": "split_0_train_27948_passage",
"type": "progene_text",
"text": [
"In this study , we examined the role of the first intron in the transcriptional regulation of the chicken apoAI gene ."
],
"offsets": [
[
0,
118
]
]
}
] |
[
{
"id": "split_0_train_45183_entity",
"type": "progene_text",
"text": [
"apoAI"
],
"offsets": [
[
106,
111
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27949
|
split_0_train_27949
|
[
{
"id": "split_0_train_27949_passage",
"type": "progene_text",
"text": [
"Six different reporter cat gene constructs with or without part of the first intron were prepared and transfected into LMH , normal rat kidney ( NRK ) and human hepatocarcinoma ( HepG2 ) cells ."
],
"offsets": [
[
0,
194
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27950
|
split_0_train_27950
|
[
{
"id": "split_0_train_27950_passage",
"type": "progene_text",
"text": [
"Cell extracts were prepared from each transfected cell line , and CAT activities were measured ."
],
"offsets": [
[
0,
96
]
]
}
] |
[
{
"id": "split_0_train_45184_entity",
"type": "progene_text",
"text": [
"CAT"
],
"offsets": [
[
66,
69
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27951
|
split_0_train_27951
|
[
{
"id": "split_0_train_27951_passage",
"type": "progene_text",
"text": [
"All three cell - lines readily expressed CAT , indicating that transcriptional regulatory sequences are present within the first intron region of the chicken apoAI gene ."
],
"offsets": [
[
0,
170
]
]
}
] |
[
{
"id": "split_0_train_45185_entity",
"type": "progene_text",
"text": [
"CAT"
],
"offsets": [
[
41,
44
]
],
"normalized": []
},
{
"id": "split_0_train_45186_entity",
"type": "progene_text",
"text": [
"apoAI"
],
"offsets": [
[
158,
163
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27952
|
split_0_train_27952
|
[
{
"id": "split_0_train_27952_passage",
"type": "progene_text",
"text": [
"In an enhancer assay , the first intron containing cat construct exhibited a 5.4 - fold increase of reporter activity in NRK cells when compared to a SV 40 promoter containing cat plasmid , suggesting the presence of a moderate enhancer element within + 29 to + 87nt of the first intron ."
],
"offsets": [
[
0,
288
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27953
|
split_0_train_27953
|
[
{
"id": "split_0_train_27953_passage",
"type": "progene_text",
"text": [
"DNase I protection assays , electrophoretic mobility shift assays and binding experiments with nuclear proteins isolated from different chicken tissues and LMH cells showed interaction with + 29 to + 87nt ."
],
"offsets": [
[
0,
206
]
]
}
] |
[
{
"id": "split_0_train_45187_entity",
"type": "progene_text",
"text": [
"DNase I"
],
"offsets": [
[
0,
7
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27954
|
split_0_train_27954
|
[
{
"id": "split_0_train_27954_passage",
"type": "progene_text",
"text": [
"Nuclear proteins isolated from tissues like liver and intestine , that actively express apoAI gene , failed to interact with + 29 to + 87nt , whereas nuclear proteins isolated from tissues that are less active in apoAI gene expression readily interacted with this region ."
],
"offsets": [
[
0,
272
]
]
}
] |
[
{
"id": "split_0_train_45188_entity",
"type": "progene_text",
"text": [
"apoAI"
],
"offsets": [
[
88,
93
]
],
"normalized": []
},
{
"id": "split_0_train_45189_entity",
"type": "progene_text",
"text": [
"apoAI"
],
"offsets": [
[
213,
218
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27955
|
split_0_train_27955
|
[
{
"id": "split_0_train_27955_passage",
"type": "progene_text",
"text": [
"To show the binding of the LMH - specific trans - acting factors to the + 50 to + 68nt intron region , DNA - affinity chromatography step was performed by using 3H - labeled nuclear proteins ."
],
"offsets": [
[
0,
192
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27956
|
split_0_train_27956
|
[
{
"id": "split_0_train_27956_passage",
"type": "progene_text",
"text": [
"These studies demonstrate that the first intron region of the apoAI gene interacts with trans - acting proteins and plays an important role in transcriptional regulation of the apoAI gene ."
],
"offsets": [
[
0,
189
]
]
}
] |
[
{
"id": "split_0_train_45190_entity",
"type": "progene_text",
"text": [
"apoAI"
],
"offsets": [
[
62,
67
]
],
"normalized": []
},
{
"id": "split_0_train_45191_entity",
"type": "progene_text",
"text": [
"apoAI"
],
"offsets": [
[
177,
182
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27957
|
split_0_train_27957
|
[
{
"id": "split_0_train_27957_passage",
"type": "progene_text",
"text": [
"A region of sigmaK involved in promoter activation by GerE in Bacillus subtilis ."
],
"offsets": [
[
0,
81
]
]
}
] |
[
{
"id": "split_0_train_45192_entity",
"type": "progene_text",
"text": [
"sigmaK"
],
"offsets": [
[
12,
18
]
],
"normalized": []
},
{
"id": "split_0_train_45193_entity",
"type": "progene_text",
"text": [
"GerE"
],
"offsets": [
[
54,
58
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27958
|
split_0_train_27958
|
[
{
"id": "split_0_train_27958_passage",
"type": "progene_text",
"text": [
"During endospore formation in Bacillus subtilis , the DNA binding protein GerE stimulates transcription from several promoters that are used by RNA polymerase containing sigmaK ."
],
"offsets": [
[
0,
178
]
]
}
] |
[
{
"id": "split_0_train_45194_entity",
"type": "progene_text",
"text": [
"GerE"
],
"offsets": [
[
74,
78
]
],
"normalized": []
},
{
"id": "split_0_train_45195_entity",
"type": "progene_text",
"text": [
"RNA polymerase"
],
"offsets": [
[
144,
158
]
],
"normalized": []
},
{
"id": "split_0_train_45196_entity",
"type": "progene_text",
"text": [
"sigmaK"
],
"offsets": [
[
170,
176
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27959
|
split_0_train_27959
|
[
{
"id": "split_0_train_27959_passage",
"type": "progene_text",
"text": [
"GerE binds to a site on one of these promoters , cotX , that overlaps its - 35 region ."
],
"offsets": [
[
0,
87
]
]
}
] |
[
{
"id": "split_0_train_45197_entity",
"type": "progene_text",
"text": [
"GerE"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_45198_entity",
"type": "progene_text",
"text": [
"cotX"
],
"offsets": [
[
49,
53
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27960
|
split_0_train_27960
|
[
{
"id": "split_0_train_27960_passage",
"type": "progene_text",
"text": [
"We tested the model that GerE interacts with sigmaK at the cotX promoter by seeking amino acid substitutions in sigmaK that interfered with GerE - dependent activation of the cotX promoter but which did not affect utilization of the sigmaK - dependent , GerE - independent promoter gerE ."
],
"offsets": [
[
0,
288
]
]
}
] |
[
{
"id": "split_0_train_45199_entity",
"type": "progene_text",
"text": [
"GerE"
],
"offsets": [
[
25,
29
]
],
"normalized": []
},
{
"id": "split_0_train_45200_entity",
"type": "progene_text",
"text": [
"sigmaK"
],
"offsets": [
[
45,
51
]
],
"normalized": []
},
{
"id": "split_0_train_45201_entity",
"type": "progene_text",
"text": [
"cotX"
],
"offsets": [
[
59,
63
]
],
"normalized": []
},
{
"id": "split_0_train_45202_entity",
"type": "progene_text",
"text": [
"sigmaK"
],
"offsets": [
[
112,
118
]
],
"normalized": []
},
{
"id": "split_0_train_45203_entity",
"type": "progene_text",
"text": [
"GerE"
],
"offsets": [
[
140,
144
]
],
"normalized": []
},
{
"id": "split_0_train_45204_entity",
"type": "progene_text",
"text": [
"cotX"
],
"offsets": [
[
175,
179
]
],
"normalized": []
},
{
"id": "split_0_train_45205_entity",
"type": "progene_text",
"text": [
"sigmaK"
],
"offsets": [
[
233,
239
]
],
"normalized": []
},
{
"id": "split_0_train_45206_entity",
"type": "progene_text",
"text": [
"GerE"
],
"offsets": [
[
254,
258
]
],
"normalized": []
},
{
"id": "split_0_train_45207_entity",
"type": "progene_text",
"text": [
"gerE"
],
"offsets": [
[
282,
286
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27961
|
split_0_train_27961
|
[
{
"id": "split_0_train_27961_passage",
"type": "progene_text",
"text": [
"We identified two amino acid substitutions in sigmaK , E216K and H225Y , that decrease cotX promoter utilization but do not affect gerE promoter activity ."
],
"offsets": [
[
0,
155
]
]
}
] |
[
{
"id": "split_0_train_45208_entity",
"type": "progene_text",
"text": [
"sigmaK"
],
"offsets": [
[
46,
52
]
],
"normalized": []
},
{
"id": "split_0_train_45209_entity",
"type": "progene_text",
"text": [
"cotX"
],
"offsets": [
[
87,
91
]
],
"normalized": []
},
{
"id": "split_0_train_45210_entity",
"type": "progene_text",
"text": [
"gerE"
],
"offsets": [
[
131,
135
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27962
|
split_0_train_27962
|
[
{
"id": "split_0_train_27962_passage",
"type": "progene_text",
"text": [
"Alanine substitutions at these positions had similar effects ."
],
"offsets": [
[
0,
62
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27963
|
split_0_train_27963
|
[
{
"id": "split_0_train_27963_passage",
"type": "progene_text",
"text": [
"We also examined the effects of the E216A and H225Y substitutions in sigmaK on transcription in vitro ."
],
"offsets": [
[
0,
103
]
]
}
] |
[
{
"id": "split_0_train_45211_entity",
"type": "progene_text",
"text": [
"sigmaK"
],
"offsets": [
[
69,
75
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27964
|
split_0_train_27964
|
[
{
"id": "split_0_train_27964_passage",
"type": "progene_text",
"text": [
"We found that these substitutions specifically reduced utilization of the cotX promoter ."
],
"offsets": [
[
0,
89
]
]
}
] |
[
{
"id": "split_0_train_45212_entity",
"type": "progene_text",
"text": [
"cotX"
],
"offsets": [
[
74,
78
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27965
|
split_0_train_27965
|
[
{
"id": "split_0_train_27965_passage",
"type": "progene_text",
"text": [
"These and other results suggest that the amino acid residues at positions 216 and 225 are required for GerE - dependent cotX promoter activity , that the histidine at position 225 of sigmaK may interact with GerE at the cotX promoter , and that this interaction may facilitate the initial binding of sigmaK RNA polymerase to the cotX promoter ."
],
"offsets": [
[
0,
344
]
]
}
] |
[
{
"id": "split_0_train_45213_entity",
"type": "progene_text",
"text": [
"GerE"
],
"offsets": [
[
103,
107
]
],
"normalized": []
},
{
"id": "split_0_train_45214_entity",
"type": "progene_text",
"text": [
"cotX"
],
"offsets": [
[
120,
124
]
],
"normalized": []
},
{
"id": "split_0_train_45215_entity",
"type": "progene_text",
"text": [
"sigmaK"
],
"offsets": [
[
183,
189
]
],
"normalized": []
},
{
"id": "split_0_train_45216_entity",
"type": "progene_text",
"text": [
"GerE"
],
"offsets": [
[
208,
212
]
],
"normalized": []
},
{
"id": "split_0_train_45217_entity",
"type": "progene_text",
"text": [
"cotX"
],
"offsets": [
[
220,
224
]
],
"normalized": []
},
{
"id": "split_0_train_45218_entity",
"type": "progene_text",
"text": [
"sigmaK"
],
"offsets": [
[
300,
306
]
],
"normalized": []
},
{
"id": "split_0_train_45219_entity",
"type": "progene_text",
"text": [
"RNA polymerase"
],
"offsets": [
[
307,
321
]
],
"normalized": []
},
{
"id": "split_0_train_45220_entity",
"type": "progene_text",
"text": [
"cotX"
],
"offsets": [
[
329,
333
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27966
|
split_0_train_27966
|
[
{
"id": "split_0_train_27966_passage",
"type": "progene_text",
"text": [
"We also found that the alanine substitutions at positions 216 and 225 of sigmaK had no effect on utilization of the GerE - dependent promoter cotD , which contains GerE binding sites that do not overlap with its - 35 region ."
],
"offsets": [
[
0,
225
]
]
}
] |
[
{
"id": "split_0_train_45221_entity",
"type": "progene_text",
"text": [
"sigmaK"
],
"offsets": [
[
73,
79
]
],
"normalized": []
},
{
"id": "split_0_train_45222_entity",
"type": "progene_text",
"text": [
"GerE"
],
"offsets": [
[
116,
120
]
],
"normalized": []
},
{
"id": "split_0_train_45223_entity",
"type": "progene_text",
"text": [
"cotD"
],
"offsets": [
[
142,
146
]
],
"normalized": []
},
{
"id": "split_0_train_45224_entity",
"type": "progene_text",
"text": [
"GerE"
],
"offsets": [
[
164,
168
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27967
|
split_0_train_27967
|
[
{
"id": "split_0_train_27967_passage",
"type": "progene_text",
"text": [
"Repression of the rat steroidogenic acute regulatory ( StAR ) protein gene by PGF2alpha is modulated by the negative transcription factor DAX-1 ."
],
"offsets": [
[
0,
145
]
]
}
] |
[
{
"id": "split_0_train_45225_entity",
"type": "progene_text",
"text": [
"steroidogenic acute regulatory"
],
"offsets": [
[
22,
52
]
],
"normalized": []
},
{
"id": "split_0_train_45226_entity",
"type": "progene_text",
"text": [
"StAR"
],
"offsets": [
[
55,
59
]
],
"normalized": []
},
{
"id": "split_0_train_45227_entity",
"type": "progene_text",
"text": [
"transcription factor"
],
"offsets": [
[
117,
137
]
],
"normalized": []
},
{
"id": "split_0_train_45228_entity",
"type": "progene_text",
"text": [
"DAX-1"
],
"offsets": [
[
138,
143
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27968
|
split_0_train_27968
|
[
{
"id": "split_0_train_27968_passage",
"type": "progene_text",
"text": [
"The steroidogenic acute regulatory protein ( StAR ) is thought to mediate the rapid increase in steroid hormone biosynthesis by facilitating cholesterol transport to the inner mitochondrial membrane ."
],
"offsets": [
[
0,
200
]
]
}
] |
[
{
"id": "split_0_train_45229_entity",
"type": "progene_text",
"text": [
"steroidogenic acute regulatory protein"
],
"offsets": [
[
4,
42
]
],
"normalized": []
},
{
"id": "split_0_train_45230_entity",
"type": "progene_text",
"text": [
"StAR"
],
"offsets": [
[
45,
49
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27969
|
split_0_train_27969
|
[
{
"id": "split_0_train_27969_passage",
"type": "progene_text",
"text": [
"Recent studies indicate that StAR gene expression is enhanced by gonadotropins , whereas prostaglandin F2alpha ( PGF2alpha ) appears to suppress both basal and gonadotropin - stimulated StAR mRNA levels ."
],
"offsets": [
[
0,
204
]
]
}
] |
[
{
"id": "split_0_train_45231_entity",
"type": "progene_text",
"text": [
"StAR"
],
"offsets": [
[
29,
33
]
],
"normalized": []
},
{
"id": "split_0_train_45232_entity",
"type": "progene_text",
"text": [
"gonadotropins"
],
"offsets": [
[
65,
78
]
],
"normalized": []
},
{
"id": "split_0_train_45233_entity",
"type": "progene_text",
"text": [
"gonadotropin"
],
"offsets": [
[
160,
172
]
],
"normalized": []
},
{
"id": "split_0_train_45234_entity",
"type": "progene_text",
"text": [
"StAR"
],
"offsets": [
[
186,
190
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27970
|
split_0_train_27970
|
[
{
"id": "split_0_train_27970_passage",
"type": "progene_text",
"text": [
"While studies have demonstrated that steroidogenic factor 1 ( SF-1 ) mediates transcriptional activation of the StAR gene , the mechanism for the reduction in StAR expression requires analysis ."
],
"offsets": [
[
0,
194
]
]
}
] |
[
{
"id": "split_0_train_45235_entity",
"type": "progene_text",
"text": [
"steroidogenic factor 1"
],
"offsets": [
[
37,
59
]
],
"normalized": []
},
{
"id": "split_0_train_45236_entity",
"type": "progene_text",
"text": [
"SF-1"
],
"offsets": [
[
62,
66
]
],
"normalized": []
},
{
"id": "split_0_train_45237_entity",
"type": "progene_text",
"text": [
"StAR"
],
"offsets": [
[
112,
116
]
],
"normalized": []
},
{
"id": "split_0_train_45238_entity",
"type": "progene_text",
"text": [
"StAR"
],
"offsets": [
[
159,
163
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27971
|
split_0_train_27971
|
[
{
"id": "split_0_train_27971_passage",
"type": "progene_text",
"text": [
"Recent studies have shown that DAX-1 ( Dosage - sensitive sex reversal adrenal hypoplasia congenita critical region on the X - chromosome , gene-1 ) , a negative transcription factor , inhibits transcription of reporter genes in vitro ."
],
"offsets": [
[
0,
236
]
]
}
] |
[
{
"id": "split_0_train_45239_entity",
"type": "progene_text",
"text": [
"DAX-1"
],
"offsets": [
[
31,
36
]
],
"normalized": []
},
{
"id": "split_0_train_45240_entity",
"type": "progene_text",
"text": [
"Dosage - sensitive sex reversal adrenal hypoplasia congenita critical region on the X - chromosome , gene-1"
],
"offsets": [
[
39,
146
]
],
"normalized": []
},
{
"id": "split_0_train_45241_entity",
"type": "progene_text",
"text": [
"transcription factor"
],
"offsets": [
[
162,
182
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27972
|
split_0_train_27972
|
[
{
"id": "split_0_train_27972_passage",
"type": "progene_text",
"text": [
"To determine whether DAX-1 could negatively regulate expression of the StAR gene , approx 2 kb of the rat StAR promoter was linked to a luciferase reporter gene ( creating p-1862 StAR ) and cotransfected into Y1 adrenal tumor cells and HTB9 human bladder carcinoma cells with vectors which encode DAX-1 and SF-1 ."
],
"offsets": [
[
0,
313
]
]
}
] |
[
{
"id": "split_0_train_45242_entity",
"type": "progene_text",
"text": [
"DAX-1"
],
"offsets": [
[
21,
26
]
],
"normalized": []
},
{
"id": "split_0_train_45243_entity",
"type": "progene_text",
"text": [
"StAR"
],
"offsets": [
[
71,
75
]
],
"normalized": []
},
{
"id": "split_0_train_45244_entity",
"type": "progene_text",
"text": [
"StAR"
],
"offsets": [
[
106,
110
]
],
"normalized": []
},
{
"id": "split_0_train_45245_entity",
"type": "progene_text",
"text": [
"luciferase"
],
"offsets": [
[
136,
146
]
],
"normalized": []
},
{
"id": "split_0_train_45246_entity",
"type": "progene_text",
"text": [
"StAR"
],
"offsets": [
[
179,
183
]
],
"normalized": []
},
{
"id": "split_0_train_45247_entity",
"type": "progene_text",
"text": [
"DAX-1"
],
"offsets": [
[
297,
302
]
],
"normalized": []
},
{
"id": "split_0_train_45248_entity",
"type": "progene_text",
"text": [
"SF-1"
],
"offsets": [
[
307,
311
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27973
|
split_0_train_27973
|
[
{
"id": "split_0_train_27973_passage",
"type": "progene_text",
"text": [
"Luciferase levels were significantly increased in both cell types when SF-1 was present ."
],
"offsets": [
[
0,
89
]
]
}
] |
[
{
"id": "split_0_train_45249_entity",
"type": "progene_text",
"text": [
"Luciferase"
],
"offsets": [
[
0,
10
]
],
"normalized": []
},
{
"id": "split_0_train_45250_entity",
"type": "progene_text",
"text": [
"SF-1"
],
"offsets": [
[
71,
75
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27974
|
split_0_train_27974
|
[
{
"id": "split_0_train_27974_passage",
"type": "progene_text",
"text": [
"In contrast , when DAX-1 was cotransfected with the StAR promoter , Y1 adrenal and HTB9 cell luciferase activities were reduced to levels that were 57 % and 24 % of basal promoter levels , respectively ."
],
"offsets": [
[
0,
203
]
]
}
] |
[
{
"id": "split_0_train_45251_entity",
"type": "progene_text",
"text": [
"DAX-1"
],
"offsets": [
[
19,
24
]
],
"normalized": []
},
{
"id": "split_0_train_45252_entity",
"type": "progene_text",
"text": [
"StAR"
],
"offsets": [
[
52,
56
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27975
|
split_0_train_27975
|
[
{
"id": "split_0_train_27975_passage",
"type": "progene_text",
"text": [
"Furthermore , when dibutyryl - cAMP ( dbcAMP ) was added to the DAX-1 expressing cells , cAMP responsiveness was repressed 50 % and 75 % in Y1s and HTB9s respectively , relative to the non - DAX-1 expressing dbcAMP - treated cells ."
],
"offsets": [
[
0,
232
]
]
}
] |
[
{
"id": "split_0_train_45253_entity",
"type": "progene_text",
"text": [
"DAX-1"
],
"offsets": [
[
64,
69
]
],
"normalized": []
},
{
"id": "split_0_train_45254_entity",
"type": "progene_text",
"text": [
"DAX-1"
],
"offsets": [
[
191,
196
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27976
|
split_0_train_27976
|
[
{
"id": "split_0_train_27976_passage",
"type": "progene_text",
"text": [
"The inhibition of StAR gene transcription by DAX-1 was dose - dependent reducing transcription to 6 % of control levels ."
],
"offsets": [
[
0,
121
]
]
}
] |
[
{
"id": "split_0_train_45255_entity",
"type": "progene_text",
"text": [
"StAR"
],
"offsets": [
[
18,
22
]
],
"normalized": []
},
{
"id": "split_0_train_45256_entity",
"type": "progene_text",
"text": [
"DAX-1"
],
"offsets": [
[
45,
50
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27977
|
split_0_train_27977
|
[
{
"id": "split_0_train_27977_passage",
"type": "progene_text",
"text": [
"Consistent with the possibility that PGF2alpha regulates ovarian StAR expression via DAX-1 , Western blot analysis indicated a three - and fivefold increase in rat ovarian DAX-1 levels at 2 and 4 h following PGF2alpha injection ( 250 microg ) ."
],
"offsets": [
[
0,
244
]
]
}
] |
[
{
"id": "split_0_train_45257_entity",
"type": "progene_text",
"text": [
"StAR"
],
"offsets": [
[
65,
69
]
],
"normalized": []
},
{
"id": "split_0_train_45258_entity",
"type": "progene_text",
"text": [
"DAX-1"
],
"offsets": [
[
85,
90
]
],
"normalized": []
},
{
"id": "split_0_train_45259_entity",
"type": "progene_text",
"text": [
"DAX-1"
],
"offsets": [
[
172,
177
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27978
|
split_0_train_27978
|
[
{
"id": "split_0_train_27978_passage",
"type": "progene_text",
"text": [
"The increase in DAX-1 protein corresponded to a 50 % reduction in StAR mRNA levels concomitant with a 39 % reduction in serum progesterone levels ."
],
"offsets": [
[
0,
147
]
]
}
] |
[
{
"id": "split_0_train_45260_entity",
"type": "progene_text",
"text": [
"DAX-1"
],
"offsets": [
[
16,
21
]
],
"normalized": []
},
{
"id": "split_0_train_45261_entity",
"type": "progene_text",
"text": [
"StAR"
],
"offsets": [
[
66,
70
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27979
|
split_0_train_27979
|
[
{
"id": "split_0_train_27979_passage",
"type": "progene_text",
"text": [
"Truncation of the DAX-1 protein at the C - terminal end caused a loss of inhibition of transcriptional activity ."
],
"offsets": [
[
0,
113
]
]
}
] |
[
{
"id": "split_0_train_45262_entity",
"type": "progene_text",
"text": [
"DAX-1"
],
"offsets": [
[
18,
23
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27980
|
split_0_train_27980
|
[
{
"id": "split_0_train_27980_passage",
"type": "progene_text",
"text": [
"Deletion of bp - 95 to - 50 within the StAR promoter , a proposed DAX-1 binding site , did not alter the ability of wild - type DAX-1 to inhibit transcription ."
],
"offsets": [
[
0,
160
]
]
}
] |
[
{
"id": "split_0_train_45263_entity",
"type": "progene_text",
"text": [
"StAR"
],
"offsets": [
[
39,
43
]
],
"normalized": []
},
{
"id": "split_0_train_45264_entity",
"type": "progene_text",
"text": [
"DAX-1"
],
"offsets": [
[
66,
71
]
],
"normalized": []
},
{
"id": "split_0_train_45265_entity",
"type": "progene_text",
"text": [
"DAX-1"
],
"offsets": [
[
128,
133
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27981
|
split_0_train_27981
|
[
{
"id": "split_0_train_27981_passage",
"type": "progene_text",
"text": [
"In a mammalian two - hybrid system , cotransfection of DAX-1 and SF-1 caused a 25 - fold induction in luciferase activity demonstrating that these proteins interact in the two - hybrid assay ."
],
"offsets": [
[
0,
192
]
]
}
] |
[
{
"id": "split_0_train_45266_entity",
"type": "progene_text",
"text": [
"DAX-1"
],
"offsets": [
[
55,
60
]
],
"normalized": []
},
{
"id": "split_0_train_45267_entity",
"type": "progene_text",
"text": [
"SF-1"
],
"offsets": [
[
65,
69
]
],
"normalized": []
},
{
"id": "split_0_train_45268_entity",
"type": "progene_text",
"text": [
"luciferase"
],
"offsets": [
[
102,
112
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27982
|
split_0_train_27982
|
[
{
"id": "split_0_train_27982_passage",
"type": "progene_text",
"text": [
"This study is the first to demonstrate that the rat StAR promoter is regulated by DAX-1 and that DAX-1 reduces StAR promoter responsiveness to cAMP ."
],
"offsets": [
[
0,
149
]
]
}
] |
[
{
"id": "split_0_train_45269_entity",
"type": "progene_text",
"text": [
"StAR"
],
"offsets": [
[
52,
56
]
],
"normalized": []
},
{
"id": "split_0_train_45270_entity",
"type": "progene_text",
"text": [
"DAX-1"
],
"offsets": [
[
82,
87
]
],
"normalized": []
},
{
"id": "split_0_train_45271_entity",
"type": "progene_text",
"text": [
"DAX-1"
],
"offsets": [
[
97,
102
]
],
"normalized": []
},
{
"id": "split_0_train_45272_entity",
"type": "progene_text",
"text": [
"StAR"
],
"offsets": [
[
111,
115
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27983
|
split_0_train_27983
|
[
{
"id": "split_0_train_27983_passage",
"type": "progene_text",
"text": [
"The enhanced level of DAX-1 following PGF2alpha administration is consistent with DAX-1 having a role in controlling both basal , gonadotropin - stimulated , and PGF2alpha - mediated StAR gene expression ."
],
"offsets": [
[
0,
205
]
]
}
] |
[
{
"id": "split_0_train_45273_entity",
"type": "progene_text",
"text": [
"DAX-1"
],
"offsets": [
[
22,
27
]
],
"normalized": []
},
{
"id": "split_0_train_45274_entity",
"type": "progene_text",
"text": [
"DAX-1"
],
"offsets": [
[
82,
87
]
],
"normalized": []
},
{
"id": "split_0_train_45275_entity",
"type": "progene_text",
"text": [
"gonadotropin"
],
"offsets": [
[
130,
142
]
],
"normalized": []
},
{
"id": "split_0_train_45276_entity",
"type": "progene_text",
"text": [
"StAR"
],
"offsets": [
[
183,
187
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27984
|
split_0_train_27984
|
[
{
"id": "split_0_train_27984_passage",
"type": "progene_text",
"text": [
"These results imply that DAX-1 has an important role in regulating ovarian steroidogenesis by repressing StAR transcription ."
],
"offsets": [
[
0,
125
]
]
}
] |
[
{
"id": "split_0_train_45277_entity",
"type": "progene_text",
"text": [
"DAX-1"
],
"offsets": [
[
25,
30
]
],
"normalized": []
},
{
"id": "split_0_train_45278_entity",
"type": "progene_text",
"text": [
"StAR"
],
"offsets": [
[
105,
109
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27985
|
split_0_train_27985
|
[
{
"id": "split_0_train_27985_passage",
"type": "progene_text",
"text": [
"The nuclear receptor corepressor N-CoR regulates differentiation : N-CoR directly interacts with MyoD ."
],
"offsets": [
[
0,
103
]
]
}
] |
[
{
"id": "split_0_train_45279_entity",
"type": "progene_text",
"text": [
"N-CoR"
],
"offsets": [
[
33,
38
]
],
"normalized": []
},
{
"id": "split_0_train_45280_entity",
"type": "progene_text",
"text": [
"N-CoR"
],
"offsets": [
[
67,
72
]
],
"normalized": []
},
{
"id": "split_0_train_45281_entity",
"type": "progene_text",
"text": [
"MyoD"
],
"offsets": [
[
97,
101
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27986
|
split_0_train_27986
|
[
{
"id": "split_0_train_27986_passage",
"type": "progene_text",
"text": [
"Classical ligand - activated nuclear receptors ( e.g. thyroid hormone receptor , retinoic acid receptor ) , orphan nuclear receptors ( e.g. Rev-erbAalpha / beta ) , Mad / Max bHLH ( basic helix loop helix ) - LZ proteins , and oncoproteins , PLZF and LAZ3 / BCL6 , bind DNA and silence transcription by recruiting a repressor complex that contains N-CoR ( nuclear receptor corepressor ) / SMRT ( silencing mediator of retinoic acid and thyroid hormone receptor ) , Sin3A / B , and HDAc-1 / - 2 proteins ."
],
"offsets": [
[
0,
504
]
]
}
] |
[
{
"id": "split_0_train_45282_entity",
"type": "progene_text",
"text": [
"thyroid hormone receptor"
],
"offsets": [
[
54,
78
]
],
"normalized": []
},
{
"id": "split_0_train_45283_entity",
"type": "progene_text",
"text": [
"retinoic acid receptor"
],
"offsets": [
[
81,
103
]
],
"normalized": []
},
{
"id": "split_0_train_45284_entity",
"type": "progene_text",
"text": [
"Rev-erbAalpha / beta"
],
"offsets": [
[
140,
160
]
],
"normalized": []
},
{
"id": "split_0_train_45285_entity",
"type": "progene_text",
"text": [
"Mad"
],
"offsets": [
[
165,
168
]
],
"normalized": []
},
{
"id": "split_0_train_45286_entity",
"type": "progene_text",
"text": [
"Max"
],
"offsets": [
[
171,
174
]
],
"normalized": []
},
{
"id": "split_0_train_45287_entity",
"type": "progene_text",
"text": [
"PLZF"
],
"offsets": [
[
242,
246
]
],
"normalized": []
},
{
"id": "split_0_train_45288_entity",
"type": "progene_text",
"text": [
"LAZ3"
],
"offsets": [
[
251,
255
]
],
"normalized": []
},
{
"id": "split_0_train_45289_entity",
"type": "progene_text",
"text": [
"BCL6"
],
"offsets": [
[
258,
262
]
],
"normalized": []
},
{
"id": "split_0_train_45290_entity",
"type": "progene_text",
"text": [
"N-CoR"
],
"offsets": [
[
348,
353
]
],
"normalized": []
},
{
"id": "split_0_train_45291_entity",
"type": "progene_text",
"text": [
"nuclear receptor corepressor"
],
"offsets": [
[
356,
384
]
],
"normalized": []
},
{
"id": "split_0_train_45292_entity",
"type": "progene_text",
"text": [
"SMRT"
],
"offsets": [
[
389,
393
]
],
"normalized": []
},
{
"id": "split_0_train_45293_entity",
"type": "progene_text",
"text": [
"silencing mediator of retinoic acid and thyroid hormone receptor"
],
"offsets": [
[
396,
460
]
],
"normalized": []
},
{
"id": "split_0_train_45294_entity",
"type": "progene_text",
"text": [
"Sin3A / B"
],
"offsets": [
[
465,
474
]
],
"normalized": []
},
{
"id": "split_0_train_45295_entity",
"type": "progene_text",
"text": [
"HDAc-1 / - 2"
],
"offsets": [
[
481,
493
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27987
|
split_0_train_27987
|
[
{
"id": "split_0_train_27987_passage",
"type": "progene_text",
"text": [
"The function of the corepressor , N-CoR , in the process of cellular differentiation and coupled phenotypic acquisition , has not been investigated ."
],
"offsets": [
[
0,
149
]
]
}
] |
[
{
"id": "split_0_train_45296_entity",
"type": "progene_text",
"text": [
"N-CoR"
],
"offsets": [
[
34,
39
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27988
|
split_0_train_27988
|
[
{
"id": "split_0_train_27988_passage",
"type": "progene_text",
"text": [
"We examined the functional role of N-CoR in myogenesis ( muscle differentiation ) , an ideal paradigm for the analysis of the determinative events that govern the cell 's decision to divide or differentiate ."
],
"offsets": [
[
0,
208
]
]
}
] |
[
{
"id": "split_0_train_45297_entity",
"type": "progene_text",
"text": [
"N-CoR"
],
"offsets": [
[
35,
40
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27989
|
split_0_train_27989
|
[
{
"id": "split_0_train_27989_passage",
"type": "progene_text",
"text": [
"We observed that the mRNA encoding N-CoR was suppressed as proliferating myoblasts exited the cell cycle , and formed morphologically and biochemically differentiated myotubes ."
],
"offsets": [
[
0,
177
]
]
}
] |
[
{
"id": "split_0_train_45298_entity",
"type": "progene_text",
"text": [
"N-CoR"
],
"offsets": [
[
35,
40
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27990
|
split_0_train_27990
|
[
{
"id": "split_0_train_27990_passage",
"type": "progene_text",
"text": [
"Exogenous expression of N-CoR ( but not RIP13 ) in myogenic cells ablated 1 ) myogenic differentiation , 2) the expression of the myoD gene family that encode the myogenic specific bHLH proteins , and 3 ) the crucial cell cycle regulator , p21Waf-1 / Cip-1 mRNA ."
],
"offsets": [
[
0,
263
]
]
}
] |
[
{
"id": "split_0_train_45299_entity",
"type": "progene_text",
"text": [
"N-CoR"
],
"offsets": [
[
24,
29
]
],
"normalized": []
},
{
"id": "split_0_train_45300_entity",
"type": "progene_text",
"text": [
"RIP13"
],
"offsets": [
[
40,
45
]
],
"normalized": []
},
{
"id": "split_0_train_45301_entity",
"type": "progene_text",
"text": [
"myoD gene family"
],
"offsets": [
[
130,
146
]
],
"normalized": []
},
{
"id": "split_0_train_45302_entity",
"type": "progene_text",
"text": [
"p21Waf-1"
],
"offsets": [
[
240,
248
]
],
"normalized": []
},
{
"id": "split_0_train_45303_entity",
"type": "progene_text",
"text": [
"Cip-1"
],
"offsets": [
[
251,
256
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27991
|
split_0_train_27991
|
[
{
"id": "split_0_train_27991_passage",
"type": "progene_text",
"text": [
"Furthermore , N-CoR expression efficiently inhibits the myoD - mediated myogenic conversion of pluripotential C3H10T1 / 2 cells ."
],
"offsets": [
[
0,
129
]
]
}
] |
[
{
"id": "split_0_train_45304_entity",
"type": "progene_text",
"text": [
"N-CoR"
],
"offsets": [
[
14,
19
]
],
"normalized": []
},
{
"id": "split_0_train_45305_entity",
"type": "progene_text",
"text": [
"myoD"
],
"offsets": [
[
56,
60
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27992
|
split_0_train_27992
|
[
{
"id": "split_0_train_27992_passage",
"type": "progene_text",
"text": [
"We demonstrate that MyoD - mediated transactivation and activity are repressed by N-CoR ."
],
"offsets": [
[
0,
89
]
]
}
] |
[
{
"id": "split_0_train_45306_entity",
"type": "progene_text",
"text": [
"MyoD"
],
"offsets": [
[
20,
24
]
],
"normalized": []
},
{
"id": "split_0_train_45307_entity",
"type": "progene_text",
"text": [
"N-CoR"
],
"offsets": [
[
82,
87
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27993
|
split_0_train_27993
|
[
{
"id": "split_0_train_27993_passage",
"type": "progene_text",
"text": [
"The mechanism involves direct interactions between MyoD and N-CoR ; moreover , the interaction was dependent on the amino - terminal repression domain ( RD1 ) of N-CoR and the bHLH region of MyoD ."
],
"offsets": [
[
0,
197
]
]
}
] |
[
{
"id": "split_0_train_45308_entity",
"type": "progene_text",
"text": [
"MyoD"
],
"offsets": [
[
51,
55
]
],
"normalized": []
},
{
"id": "split_0_train_45309_entity",
"type": "progene_text",
"text": [
"N-CoR"
],
"offsets": [
[
60,
65
]
],
"normalized": []
},
{
"id": "split_0_train_45310_entity",
"type": "progene_text",
"text": [
"N-CoR"
],
"offsets": [
[
162,
167
]
],
"normalized": []
},
{
"id": "split_0_train_45311_entity",
"type": "progene_text",
"text": [
"MyoD"
],
"offsets": [
[
191,
195
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27994
|
split_0_train_27994
|
[
{
"id": "split_0_train_27994_passage",
"type": "progene_text",
"text": [
"Trichostatin A treatment significantly stimulated the activity of MyoD by approximately 10 - fold and inhibited the ability of N-CoR to repress MyoD - mediated transactivation , consistent with the involvement of the corepressor and the recruitment of a histone deacteylase activity in the process ."
],
"offsets": [
[
0,
299
]
]
}
] |
[
{
"id": "split_0_train_45312_entity",
"type": "progene_text",
"text": [
"MyoD"
],
"offsets": [
[
66,
70
]
],
"normalized": []
},
{
"id": "split_0_train_45313_entity",
"type": "progene_text",
"text": [
"N-CoR"
],
"offsets": [
[
127,
132
]
],
"normalized": []
},
{
"id": "split_0_train_45314_entity",
"type": "progene_text",
"text": [
"MyoD"
],
"offsets": [
[
144,
148
]
],
"normalized": []
},
{
"id": "split_0_train_45315_entity",
"type": "progene_text",
"text": [
"histone deacteylase"
],
"offsets": [
[
254,
273
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27995
|
split_0_train_27995
|
[
{
"id": "split_0_train_27995_passage",
"type": "progene_text",
"text": [
"This work demonstrates that the corepressor N-CoR is a key regulator of MyoD activity and mammalian differentiation , and that N-CoR has a multifaceted role in myogenesis ."
],
"offsets": [
[
0,
172
]
]
}
] |
[
{
"id": "split_0_train_45316_entity",
"type": "progene_text",
"text": [
"N-CoR"
],
"offsets": [
[
44,
49
]
],
"normalized": []
},
{
"id": "split_0_train_45317_entity",
"type": "progene_text",
"text": [
"MyoD"
],
"offsets": [
[
72,
76
]
],
"normalized": []
},
{
"id": "split_0_train_45318_entity",
"type": "progene_text",
"text": [
"N-CoR"
],
"offsets": [
[
127,
132
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27996
|
split_0_train_27996
|
[
{
"id": "split_0_train_27996_passage",
"type": "progene_text",
"text": [
"Cdc4 , a protein required for the onset of S phase , serves an essential function during G(2) / M transition in Saccharomyces cerevisiae ."
],
"offsets": [
[
0,
138
]
]
}
] |
[
{
"id": "split_0_train_45319_entity",
"type": "progene_text",
"text": [
"Cdc4"
],
"offsets": [
[
0,
4
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27997
|
split_0_train_27997
|
[
{
"id": "split_0_train_27997_passage",
"type": "progene_text",
"text": [
"Saccharomyces cerevisiae proteins Cdc4 and Cdc20 contain WD40 repeats and participate in proteolytic processes ."
],
"offsets": [
[
0,
112
]
]
}
] |
[
{
"id": "split_0_train_45320_entity",
"type": "progene_text",
"text": [
"Cdc4"
],
"offsets": [
[
34,
38
]
],
"normalized": []
},
{
"id": "split_0_train_45321_entity",
"type": "progene_text",
"text": [
"Cdc20"
],
"offsets": [
[
43,
48
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27998
|
split_0_train_27998
|
[
{
"id": "split_0_train_27998_passage",
"type": "progene_text",
"text": [
"However , they are thought to act at two different stages of the cell cycle : Cdc4 is involved in the proteolysis of the Cdk inhibitor , Sic1 , necessary for G(1) / S transition , while Cdc20 mediates anaphase - promoting complex - dependent degradation of anaphase inhibitor Pds1 , a process necessary for the onset of chromosome segregation ."
],
"offsets": [
[
0,
344
]
]
}
] |
[
{
"id": "split_0_train_45322_entity",
"type": "progene_text",
"text": [
"Cdc4"
],
"offsets": [
[
78,
82
]
],
"normalized": []
},
{
"id": "split_0_train_45323_entity",
"type": "progene_text",
"text": [
"Cdk inhibitor"
],
"offsets": [
[
121,
134
]
],
"normalized": []
},
{
"id": "split_0_train_45324_entity",
"type": "progene_text",
"text": [
"Sic1"
],
"offsets": [
[
137,
141
]
],
"normalized": []
},
{
"id": "split_0_train_45325_entity",
"type": "progene_text",
"text": [
"Cdc20"
],
"offsets": [
[
186,
191
]
],
"normalized": []
},
{
"id": "split_0_train_45326_entity",
"type": "progene_text",
"text": [
"anaphase - promoting complex"
],
"offsets": [
[
201,
229
]
],
"normalized": []
},
{
"id": "split_0_train_45327_entity",
"type": "progene_text",
"text": [
"Pds1"
],
"offsets": [
[
276,
280
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27999
|
split_0_train_27999
|
[
{
"id": "split_0_train_27999_passage",
"type": "progene_text",
"text": [
"We have isolated three mutant alleles of CDC4 ( cdc4 - 10 , cdc4 - 11 , and cdc4 - 16 ) which suppress the nuclear division defect of cdc20 - 1 cells ."
],
"offsets": [
[
0,
151
]
]
}
] |
[
{
"id": "split_0_train_45328_entity",
"type": "progene_text",
"text": [
"CDC4"
],
"offsets": [
[
41,
45
]
],
"normalized": []
},
{
"id": "split_0_train_45329_entity",
"type": "progene_text",
"text": [
"cdc4"
],
"offsets": [
[
48,
52
]
],
"normalized": []
},
{
"id": "split_0_train_45330_entity",
"type": "progene_text",
"text": [
"cdc4"
],
"offsets": [
[
60,
64
]
],
"normalized": []
},
{
"id": "split_0_train_45331_entity",
"type": "progene_text",
"text": [
"cdc4"
],
"offsets": [
[
76,
80
]
],
"normalized": []
},
{
"id": "split_0_train_45332_entity",
"type": "progene_text",
"text": [
"cdc20"
],
"offsets": [
[
134,
139
]
],
"normalized": []
}
] |
[] |
[] |
[] |
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