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split_0_train_5200
split_0_train_5200
[ { "id": "split_0_train_5200_passage", "type": "progene_text", "text": [ "CONCLUSIONS :" ], "offsets": [ [ 0, 13 ] ] } ]
[]
[]
[]
[]
split_0_train_5201
split_0_train_5201
[ { "id": "split_0_train_5201_passage", "type": "progene_text", "text": [ "Of the pinhole techniques compared , 15 - minute and 2-hour Tc-99m MIBI images with correlative thyroid scanning may be the preferred imaging protocol , because this yields results similar to imaging for as long as 4 hours after injection in a shorter , more logistically acceptable imaging time ." ], "offsets": [ [ 0, 297 ] ] } ]
[]
[]
[]
[]
split_0_train_5202
split_0_train_5202
[ { "id": "split_0_train_5202_passage", "type": "progene_text", "text": [ "Importance of increased intestinal permeability after multiple injuries ." ], "offsets": [ [ 0, 73 ] ] } ]
[]
[]
[]
[]
split_0_train_5203
split_0_train_5203
[ { "id": "split_0_train_5203_passage", "type": "progene_text", "text": [ "OBJECTIVE :" ], "offsets": [ [ 0, 11 ] ] } ]
[]
[]
[]
[]
split_0_train_5204
split_0_train_5204
[ { "id": "split_0_train_5204_passage", "type": "progene_text", "text": [ "To find out if there was a relationship between increased intestinal permeability and the development of multiple organ failure ( MOF ) after multiple injuries , we correlated the extent of injury and MOF with intestinal permeability on the second and fourth day after injury ." ], "offsets": [ [ 0, 277 ] ] } ]
[]
[]
[]
[]
split_0_train_5205
split_0_train_5205
[ { "id": "split_0_train_5205_passage", "type": "progene_text", "text": [ "DESIGN :" ], "offsets": [ [ 0, 8 ] ] } ]
[]
[]
[]
[]
split_0_train_5206
split_0_train_5206
[ { "id": "split_0_train_5206_passage", "type": "progene_text", "text": [ "Prospective open study ." ], "offsets": [ [ 0, 24 ] ] } ]
[]
[]
[]
[]
split_0_train_5207
split_0_train_5207
[ { "id": "split_0_train_5207_passage", "type": "progene_text", "text": [ "SETTING :" ], "offsets": [ [ 0, 9 ] ] } ]
[]
[]
[]
[]
split_0_train_5208
split_0_train_5208
[ { "id": "split_0_train_5208_passage", "type": "progene_text", "text": [ "University hospital , Slovenia ." ], "offsets": [ [ 0, 32 ] ] } ]
[]
[]
[]
[]
split_0_train_5209
split_0_train_5209
[ { "id": "split_0_train_5209_passage", "type": "progene_text", "text": [ "PATIENTS :" ], "offsets": [ [ 0, 10 ] ] } ]
[]
[]
[]
[]
split_0_train_5210
split_0_train_5210
[ { "id": "split_0_train_5210_passage", "type": "progene_text", "text": [ "29 multiply injured patients , injury severity score ( ISS ) over 25 , admitted shocked ." ], "offsets": [ [ 0, 89 ] ] } ]
[]
[]
[]
[]
split_0_train_5211
split_0_train_5211
[ { "id": "split_0_train_5211_passage", "type": "progene_text", "text": [ "INTERVENTION :" ], "offsets": [ [ 0, 14 ] ] } ]
[]
[]
[]
[]
split_0_train_5212
split_0_train_5212
[ { "id": "split_0_train_5212_passage", "type": "progene_text", "text": [ "Intestinal permeability measured by giving lactulose and mannitol solution enterally on days 2 and 4 ." ], "offsets": [ [ 0, 102 ] ] } ]
[]
[]
[]
[]
split_0_train_5213
split_0_train_5213
[ { "id": "split_0_train_5213_passage", "type": "progene_text", "text": [ "MAIN OUTCOME MEASURES :" ], "offsets": [ [ 0, 23 ] ] } ]
[]
[]
[]
[]
split_0_train_5214
split_0_train_5214
[ { "id": "split_0_train_5214_passage", "type": "progene_text", "text": [ "The lactulose : mannitol ratio calculated from the urinary portion of the probe molecules ." ], "offsets": [ [ 0, 91 ] ] } ]
[]
[]
[]
[]
split_0_train_5215
split_0_train_5215
[ { "id": "split_0_train_5215_passage", "type": "progene_text", "text": [ "ISS and the acute physiology and chronic health evaluation ( APACHE II ) calculated on admission ." ], "offsets": [ [ 0, 98 ] ] } ]
[]
[]
[]
[]
split_0_train_5216
split_0_train_5216
[ { "id": "split_0_train_5216_passage", "type": "progene_text", "text": [ "RESULTS :" ], "offsets": [ [ 0, 9 ] ] } ]
[]
[]
[]
[]
split_0_train_5217
split_0_train_5217
[ { "id": "split_0_train_5217_passage", "type": "progene_text", "text": [ "The median lactulose : mannitol ratio for five volunteers was 0.014 ( range 0.008 - 0.017 ) and that for 29 patients was 0.03 ( 0.01 - 0.1 ) ." ], "offsets": [ [ 0, 142 ] ] } ]
[]
[]
[]
[]
split_0_train_5218
split_0_train_5218
[ { "id": "split_0_train_5218_passage", "type": "progene_text", "text": [ "On day 2 it was 0.03 ( 0.02 - 0.1 ) , on day 4 0.02 ( 0.01 - 0.2 ) ." ], "offsets": [ [ 0, 68 ] ] } ]
[]
[]
[]
[]
split_0_train_5219
split_0_train_5219
[ { "id": "split_0_train_5219_passage", "type": "progene_text", "text": [ "The ratio calculated on day 2 correlated with average and late MOF scores ( r = 0.41 R2 = 0.1681 , p < 0.03 and r = 0.38 , R2 = 0.1444 , p < 0.04 ) and that measured on day 4 correlated with overall , early , and late MOF scores ( r = 0.47 , R2 = 0.2209 , p < 0.01 ; r = 0.51 , R2 = 0.2601 , p < 0.005 ; r = 0.39 , R = 0.1512 , p < 0.04 ) ." ], "offsets": [ [ 0, 340 ] ] } ]
[]
[]
[]
[]
split_0_train_5220
split_0_train_5220
[ { "id": "split_0_train_5220_passage", "type": "progene_text", "text": [ "No correlation was found between ISS , transport time , shock index , APACHE II , and days in intensive care ." ], "offsets": [ [ 0, 110 ] ] } ]
[]
[]
[]
[]
split_0_train_5221
split_0_train_5221
[ { "id": "split_0_train_5221_passage", "type": "progene_text", "text": [ "CONCLUSIONS :" ], "offsets": [ [ 0, 13 ] ] } ]
[]
[]
[]
[]
split_0_train_5222
split_0_train_5222
[ { "id": "split_0_train_5222_passage", "type": "progene_text", "text": [ "Even if intestinal permeability is invariably increased after injury , it seems to have some predictive value for MOF in multiply injured patients because it correlates with its development ." ], "offsets": [ [ 0, 191 ] ] } ]
[]
[]
[]
[]
split_0_train_5223
split_0_train_5223
[ { "id": "split_0_train_5223_passage", "type": "progene_text", "text": [ "Short - Term dermal absorption and penetration of chemicals from aqueous solutions : theory and experiment ." ], "offsets": [ [ 0, 108 ] ] } ]
[]
[]
[]
[]
split_0_train_5224
split_0_train_5224
[ { "id": "split_0_train_5224_passage", "type": "progene_text", "text": [ "Dermal penetration of organic chemical - contaminated water from showering and bathing scenarios is a concern of regulatory agencies that have been tasked with determining safe exposure levels ." ], "offsets": [ [ 0, 194 ] ] } ]
[]
[]
[]
[]
split_0_train_5225
split_0_train_5225
[ { "id": "split_0_train_5225_passage", "type": "progene_text", "text": [ "During household showering and bathing , nearly the entire surface area of the body is exposed for short periods of time ( 5-15 minutes ) ." ], "offsets": [ [ 0, 139 ] ] } ]
[]
[]
[]
[]
split_0_train_5226
split_0_train_5226
[ { "id": "split_0_train_5226_passage", "type": "progene_text", "text": [ "The primary means of predicting body burden during brief exposures is to estimate total chemical penetrated from the steady - state penetration rate using a skin permeability coefficient ." ], "offsets": [ [ 0, 188 ] ] } ]
[]
[]
[]
[]
split_0_train_5227
split_0_train_5227
[ { "id": "split_0_train_5227_passage", "type": "progene_text", "text": [ "A variety of approaches has been recommended to estimate \" body burden. \"" ], "offsets": [ [ 0, 73 ] ] } ]
[]
[]
[]
[]
split_0_train_5228
split_0_train_5228
[ { "id": "split_0_train_5228_passage", "type": "progene_text", "text": [ "The purpose of this investigation was to collect experimental data from short - term exposures to an organic chemical ( dibromomethane [DBM]) in aqueous solution so that methods for estimating body burden could be compared ." ], "offsets": [ [ 0, 224 ] ] } ]
[]
[]
[]
[]
split_0_train_5229
split_0_train_5229
[ { "id": "split_0_train_5229_passage", "type": "progene_text", "text": [ "Rat skins were exposed in vitro to saturated aqueous solutions of DBM for 20 minutes and the amount of chemical in the receptor solution and the skin was analyzed ." ], "offsets": [ [ 0, 164 ] ] } ]
[]
[]
[]
[]
split_0_train_5230
split_0_train_5230
[ { "id": "split_0_train_5230_passage", "type": "progene_text", "text": [ "The total DBM mass in the receptor solution and the skin was taken to represent an in vivo body burden ." ], "offsets": [ [ 0, 104 ] ] } ]
[]
[]
[]
[]
split_0_train_5231
split_0_train_5231
[ { "id": "split_0_train_5231_passage", "type": "progene_text", "text": [ "These results were compared with the estimates of penetration from steady - state calculations , square root of time calculations , and a biologically based mathematical model ." ], "offsets": [ [ 0, 177 ] ] } ]
[]
[]
[]
[]
split_0_train_5232
split_0_train_5232
[ { "id": "split_0_train_5232_passage", "type": "progene_text", "text": [ "Results indicated that the amount of chemical in the skin and its fate during short exposures is important ." ], "offsets": [ [ 0, 108 ] ] } ]
[]
[]
[]
[]
split_0_train_5233
split_0_train_5233
[ { "id": "split_0_train_5233_passage", "type": "progene_text", "text": [ "The square root of time approach predicted total amount of chemical absorbed and penetrated better than did the steady - state approach ." ], "offsets": [ [ 0, 137 ] ] } ]
[]
[]
[]
[]
split_0_train_5234
split_0_train_5234
[ { "id": "split_0_train_5234_passage", "type": "progene_text", "text": [ "The biologically based mathematical model accurately predicted total body burden and could be used to distinguish between the amount of chemical in the skin and the amount of chemical that penetrated through the skin , which would be useful for understanding local toxicity ." ], "offsets": [ [ 0, 275 ] ] } ]
[]
[]
[]
[]
split_0_train_5235
split_0_train_5235
[ { "id": "split_0_train_5235_passage", "type": "progene_text", "text": [ "Expression of multidrug resistance 1 and glutathione-S-transferase-Pi protein in nasopharyngeal carcinoma ." ], "offsets": [ [ 0, 107 ] ] } ]
[ { "id": "split_0_train_8264_entity", "type": "progene_text", "text": [ "multidrug resistance 1" ], "offsets": [ [ 14, 36 ] ], "normalized": [] }, { "id": "split_0_train_8265_entity", "type": "progene_text", "text": [ "glutathione-S-transferase-Pi" ], "offsets": [ [ 41, 69 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_5236
split_0_train_5236
[ { "id": "split_0_train_5236_passage", "type": "progene_text", "text": [ "Radiotherapy is the modality of choice for the treatment of nasopharyngeal carcinoma ( NPC ) ." ], "offsets": [ [ 0, 94 ] ] } ]
[]
[]
[]
[]
split_0_train_5237
split_0_train_5237
[ { "id": "split_0_train_5237_passage", "type": "progene_text", "text": [ "However , systemic chemotherapy has recently been found to play an increasing role in the treatment of advanced or metastatic disease ." ], "offsets": [ [ 0, 135 ] ] } ]
[]
[]
[]
[]
split_0_train_5238
split_0_train_5238
[ { "id": "split_0_train_5238_passage", "type": "progene_text", "text": [ "The status of drug resistance gene expression that has crucial impact on chemotherapy has not been fully addressed for patients with NPC ." ], "offsets": [ [ 0, 138 ] ] } ]
[]
[]
[]
[]
split_0_train_5239
split_0_train_5239
[ { "id": "split_0_train_5239_passage", "type": "progene_text", "text": [ "In this study , we examined the expression of multidrug resistance 1 ( MDR-1 ) and glutathione - S-transferase-Pi ( GST-Pi ) in primary , recurrent , and metastatic NPC using results of immunohistochemical examinations ." ], "offsets": [ [ 0, 220 ] ] } ]
[ { "id": "split_0_train_8266_entity", "type": "progene_text", "text": [ "multidrug resistance 1" ], "offsets": [ [ 46, 68 ] ], "normalized": [] }, { "id": "split_0_train_8267_entity", "type": "progene_text", "text": [ "MDR-1" ], "offsets": [ [ 71, 76 ] ], "normalized": [] }, { "id": "split_0_train_8268_entity", "type": "progene_text", "text": [ "glutathione - S-transferase-Pi" ], "offsets": [ [ 83, 113 ] ], "normalized": [] }, { "id": "split_0_train_8269_entity", "type": "progene_text", "text": [ "GST-Pi" ], "offsets": [ [ 116, 122 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_5240
split_0_train_5240
[ { "id": "split_0_train_5240_passage", "type": "progene_text", "text": [ "The results were correlated with the expression of Epstein - Barr virus ( EBV ) latent protein , latent membrane protein 1 ( LMP1 ) , and clinicopathologic features , including stage , histopathologic types , and survival rates ." ], "offsets": [ [ 0, 229 ] ] } ]
[ { "id": "split_0_train_8270_entity", "type": "progene_text", "text": [ "latent membrane protein 1" ], "offsets": [ [ 97, 122 ] ], "normalized": [] }, { "id": "split_0_train_8271_entity", "type": "progene_text", "text": [ "LMP1" ], "offsets": [ [ 125, 129 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_5241
split_0_train_5241
[ { "id": "split_0_train_5241_passage", "type": "progene_text", "text": [ "MDR-1 protein expression was detected in 18 ( 12.6 % ) of 143 patients with primary NPC , 14 ( 32.6 % ) of 43 with recurrent NPC , and O ( 0 % ) of 20 with metastatic NPC , whereas 83 ( 58 % ) of 143 patients with primary NPC , 30 ( 69.8 % ) of 43 with recurrent NPC , and 13 ( 65 % ) of 20 with metastatic NPC expressed GST-Pi ." ], "offsets": [ [ 0, 329 ] ] } ]
[ { "id": "split_0_train_8272_entity", "type": "progene_text", "text": [ "MDR-1" ], "offsets": [ [ 0, 5 ] ], "normalized": [] }, { "id": "split_0_train_8273_entity", "type": "progene_text", "text": [ "GST-Pi" ], "offsets": [ [ 321, 327 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_5242
split_0_train_5242
[ { "id": "split_0_train_5242_passage", "type": "progene_text", "text": [ "EBV - LMP1 was expressed in 59 ( 41.3 % ) of 143 patients with primary NPC , 23 ( 53.5 % ) of 43 with recurrent NPC , and 9 ( 45 % ) of 20 with metastatic NPC ." ], "offsets": [ [ 0, 160 ] ] } ]
[ { "id": "split_0_train_8274_entity", "type": "progene_text", "text": [ "LMP1" ], "offsets": [ [ 6, 10 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_5243
split_0_train_5243
[ { "id": "split_0_train_5243_passage", "type": "progene_text", "text": [ "Simultaneous expression of MDR1 and GST-Pi was observed in 13 ( 72.2 % ) of 18 patients with primary NPC and 12 ( 85.7 % ) of 14 with recurrent NPC ." ], "offsets": [ [ 0, 149 ] ] } ]
[ { "id": "split_0_train_8275_entity", "type": "progene_text", "text": [ "MDR1" ], "offsets": [ [ 27, 31 ] ], "normalized": [] }, { "id": "split_0_train_8276_entity", "type": "progene_text", "text": [ "GST-Pi" ], "offsets": [ [ 36, 42 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_5244
split_0_train_5244
[ { "id": "split_0_train_5244_passage", "type": "progene_text", "text": [ "The expression of LMP1 was detected in only 6 of the 13 patients with primary NPC and 6 of the 12 with recurrent NPC ." ], "offsets": [ [ 0, 118 ] ] } ]
[ { "id": "split_0_train_8277_entity", "type": "progene_text", "text": [ "LMP1" ], "offsets": [ [ 18, 22 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_5245
split_0_train_5245
[ { "id": "split_0_train_5245_passage", "type": "progene_text", "text": [ "We concluded that the expression of GST-Pi was more frequent in NPC tumor tissues than the expression of MDR-1 ." ], "offsets": [ [ 0, 112 ] ] } ]
[ { "id": "split_0_train_8278_entity", "type": "progene_text", "text": [ "GST-Pi" ], "offsets": [ [ 36, 42 ] ], "normalized": [] }, { "id": "split_0_train_8279_entity", "type": "progene_text", "text": [ "MDR-1" ], "offsets": [ [ 105, 110 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_5246
split_0_train_5246
[ { "id": "split_0_train_5246_passage", "type": "progene_text", "text": [ "The expression of MDR-1 correlated with clinicopathologic features of primary NPC , including the histopathologic types and survival rates , but not with disease stage ." ], "offsets": [ [ 0, 169 ] ] } ]
[ { "id": "split_0_train_8280_entity", "type": "progene_text", "text": [ "MDR-1" ], "offsets": [ [ 18, 23 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_5247
split_0_train_5247
[ { "id": "split_0_train_5247_passage", "type": "progene_text", "text": [ "The expression of GST-Pi did not correlate with clinicopathologic features ." ], "offsets": [ [ 0, 76 ] ] } ]
[ { "id": "split_0_train_8281_entity", "type": "progene_text", "text": [ "GST-Pi" ], "offsets": [ [ 18, 24 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_5248
split_0_train_5248
[ { "id": "split_0_train_5248_passage", "type": "progene_text", "text": [ "The expression of MDR-1 and GST-Pi did not correlate with expression of EBV - LMP1 for patients with NPC ." ], "offsets": [ [ 0, 106 ] ] } ]
[ { "id": "split_0_train_8282_entity", "type": "progene_text", "text": [ "MDR-1" ], "offsets": [ [ 18, 23 ] ], "normalized": [] }, { "id": "split_0_train_8283_entity", "type": "progene_text", "text": [ "GST-Pi" ], "offsets": [ [ 28, 34 ] ], "normalized": [] }, { "id": "split_0_train_8284_entity", "type": "progene_text", "text": [ "LMP1" ], "offsets": [ [ 78, 82 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_5249
split_0_train_5249
[ { "id": "split_0_train_5249_passage", "type": "progene_text", "text": [ "SYT associates with human SNF / SWI complexes and the C - terminal region of its fusion partner SSX1 targets histones ." ], "offsets": [ [ 0, 119 ] ] } ]
[ { "id": "split_0_train_8285_entity", "type": "progene_text", "text": [ "SYT" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "split_0_train_8286_entity", "type": "progene_text", "text": [ "SNF / SWI complexes" ], "offsets": [ [ 26, 45 ] ], "normalized": [] }, { "id": "split_0_train_8287_entity", "type": "progene_text", "text": [ "SSX1" ], "offsets": [ [ 96, 100 ] ], "normalized": [] }, { "id": "split_0_train_8288_entity", "type": "progene_text", "text": [ "histones" ], "offsets": [ [ 109, 117 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_5250
split_0_train_5250
[ { "id": "split_0_train_5250_passage", "type": "progene_text", "text": [ "A global transcriptional co - activator , the SNF / SWI complex , has been characterized as a chromatin remodeling factor that enhances accessibility of the transcriptional machinery to DNA within a repressive chromatin structure ." ], "offsets": [ [ 0, 231 ] ] } ]
[ { "id": "split_0_train_8289_entity", "type": "progene_text", "text": [ "SNF / SWI complex" ], "offsets": [ [ 46, 63 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_5251
split_0_train_5251
[ { "id": "split_0_train_5251_passage", "type": "progene_text", "text": [ "On the other hand , mutations in some human SNF / SWI complex components have been linked to tumor formation ." ], "offsets": [ [ 0, 110 ] ] } ]
[ { "id": "split_0_train_8290_entity", "type": "progene_text", "text": [ "SNF / SWI complex" ], "offsets": [ [ 44, 61 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_5252
split_0_train_5252
[ { "id": "split_0_train_5252_passage", "type": "progene_text", "text": [ "We show here that SYT , a partner protein generating the synovial sarcoma fusion protein SYT - SSX , associates with native human SNF / SWI complexes ." ], "offsets": [ [ 0, 151 ] ] } ]
[ { "id": "split_0_train_8291_entity", "type": "progene_text", "text": [ "SYT" ], "offsets": [ [ 18, 21 ] ], "normalized": [] }, { "id": "split_0_train_8292_entity", "type": "progene_text", "text": [ "SYT" ], "offsets": [ [ 89, 92 ] ], "normalized": [] }, { "id": "split_0_train_8293_entity", "type": "progene_text", "text": [ "SSX" ], "offsets": [ [ 95, 98 ] ], "normalized": [] }, { "id": "split_0_train_8294_entity", "type": "progene_text", "text": [ "SNF / SWI complexes" ], "offsets": [ [ 130, 149 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_5253
split_0_train_5253
[ { "id": "split_0_train_5253_passage", "type": "progene_text", "text": [ "The SYT protein has a unique QPGY domain , which is also present in the largest subunits , p250 and the newly identified homolog p250R , of the corresponding SNF / SWI complexes ." ], "offsets": [ [ 0, 179 ] ] } ]
[ { "id": "split_0_train_8295_entity", "type": "progene_text", "text": [ "SYT" ], "offsets": [ [ 4, 7 ] ], "normalized": [] }, { "id": "split_0_train_8296_entity", "type": "progene_text", "text": [ "SNF / SWI complexes" ], "offsets": [ [ 158, 177 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_5254
split_0_train_5254
[ { "id": "split_0_train_5254_passage", "type": "progene_text", "text": [ "The C - terminal region ( amino acids 310 - 387 ) of SSX1 , comprising the SSX1 portion of the SYT - SSX1 fusion protein , binds strongly to core histones and oligonucleosomes in vitro and directs nuclear localization of a green fluorescence protein fusion protein ." ], "offsets": [ [ 0, 266 ] ] } ]
[ { "id": "split_0_train_8297_entity", "type": "progene_text", "text": [ "SSX1" ], "offsets": [ [ 53, 57 ] ], "normalized": [] }, { "id": "split_0_train_8298_entity", "type": "progene_text", "text": [ "SSX1" ], "offsets": [ [ 75, 79 ] ], "normalized": [] }, { "id": "split_0_train_8299_entity", "type": "progene_text", "text": [ "SYT" ], "offsets": [ [ 95, 98 ] ], "normalized": [] }, { "id": "split_0_train_8300_entity", "type": "progene_text", "text": [ "SSX1" ], "offsets": [ [ 101, 105 ] ], "normalized": [] }, { "id": "split_0_train_8301_entity", "type": "progene_text", "text": [ "histones" ], "offsets": [ [ 146, 154 ] ], "normalized": [] }, { "id": "split_0_train_8302_entity", "type": "progene_text", "text": [ "green fluorescence protein" ], "offsets": [ [ 223, 249 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_5255
split_0_train_5255
[ { "id": "split_0_train_5255_passage", "type": "progene_text", "text": [ "Experiments with serial C - terminal deletion mutants of SSX1 indicate that these properties map to a common region and also correlate with the previously demonstrated anchorage - independent colony formation activity of SYT - SSX in Rat 3Y1 cells ." ], "offsets": [ [ 0, 249 ] ] } ]
[ { "id": "split_0_train_8303_entity", "type": "progene_text", "text": [ "SSX1" ], "offsets": [ [ 57, 61 ] ], "normalized": [] }, { "id": "split_0_train_8304_entity", "type": "progene_text", "text": [ "SYT" ], "offsets": [ [ 221, 224 ] ], "normalized": [] }, { "id": "split_0_train_8305_entity", "type": "progene_text", "text": [ "SSX" ], "offsets": [ [ 227, 230 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_5256
split_0_train_5256
[ { "id": "split_0_train_5256_passage", "type": "progene_text", "text": [ "These data suggest that SYT - SSX interferes with the function of either the SNF / SWI complexes or another SYT - interacting co - activator , p300 , by changing their targeted localization or by directly inhibiting their chromatin remodeling activities ." ], "offsets": [ [ 0, 255 ] ] } ]
[ { "id": "split_0_train_8306_entity", "type": "progene_text", "text": [ "SYT" ], "offsets": [ [ 24, 27 ] ], "normalized": [] }, { "id": "split_0_train_8307_entity", "type": "progene_text", "text": [ "SSX" ], "offsets": [ [ 30, 33 ] ], "normalized": [] }, { "id": "split_0_train_8308_entity", "type": "progene_text", "text": [ "SNF / SWI complexes" ], "offsets": [ [ 77, 96 ] ], "normalized": [] }, { "id": "split_0_train_8309_entity", "type": "progene_text", "text": [ "SYT" ], "offsets": [ [ 108, 111 ] ], "normalized": [] }, { "id": "split_0_train_8310_entity", "type": "progene_text", "text": [ "p300" ], "offsets": [ [ 143, 147 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_5257
split_0_train_5257
[ { "id": "split_0_train_5257_passage", "type": "progene_text", "text": [ "Insecticidal sesquiterpene polyol esters from Celastrus angulatus ." ], "offsets": [ [ 0, 67 ] ] } ]
[]
[]
[]
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split_0_train_5258
split_0_train_5258
[ { "id": "split_0_train_5258_passage", "type": "progene_text", "text": [ "Three insecticidal sesquiterpene polyol esters were isolated from the root bark of Celastrus angulatus by bioassay - guided fractionation ." ], "offsets": [ [ 0, 139 ] ] } ]
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[]
[]
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split_0_train_5259
split_0_train_5259
[ { "id": "split_0_train_5259_passage", "type": "progene_text", "text": [ "Their chemical structures were elucidated as 1 alpha,2 alpha-diacetoxy-8 beta-isobutanoyloxy - 9 alpha-benzoyloxy-13-(alpha-methyl)butanoyloxy-4 beta , 6 beta-dihydroxy-beta-dihydroagarofuran ( 1 ) , 1 alpha,2 alpha-diacetoxy-8 beta - ( beta - furancarbonyloxy ) - 9 alpha-benzoyloxy-13-isobutanoyloxy-4 beta , 6 beta-dihydroxy-beta-dihydroagarofuran (2) and 1 alpha , 6 beta , 8 alpha,13-tetraacetoxy-9 alpha-benzoyloxy-2 alpha-hydroxy-beta-dihydroagarofuran ( 3 ) mainly by analyses NMR and MS spectral data ." ], "offsets": [ [ 0, 511 ] ] } ]
[]
[]
[]
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split_0_train_5260
split_0_train_5260
[ { "id": "split_0_train_5260_passage", "type": "progene_text", "text": [ "IscR , an Fe-S cluster - containing transcription factor , represses expression of Escherichia coli genes encoding Fe-S cluster assembly proteins ." ], "offsets": [ [ 0, 147 ] ] } ]
[ { "id": "split_0_train_8311_entity", "type": "progene_text", "text": [ "IscR" ], "offsets": [ [ 0, 4 ] ], "normalized": [] }, { "id": "split_0_train_8312_entity", "type": "progene_text", "text": [ "transcription factor" ], "offsets": [ [ 36, 56 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_5261
split_0_train_5261
[ { "id": "split_0_train_5261_passage", "type": "progene_text", "text": [ "IscR ( iron - sulfur cluster regulator ) is encoded by an ORF located immediately upstream of genes coding for the Escherichia coli Fe-S cluster assembly proteins , IscS , IscU , and IscA ." ], "offsets": [ [ 0, 189 ] ] } ]
[ { "id": "split_0_train_8313_entity", "type": "progene_text", "text": [ "IscR" ], "offsets": [ [ 0, 4 ] ], "normalized": [] }, { "id": "split_0_train_8314_entity", "type": "progene_text", "text": [ "iron - sulfur cluster regulator" ], "offsets": [ [ 7, 38 ] ], "normalized": [] }, { "id": "split_0_train_8315_entity", "type": "progene_text", "text": [ "IscS" ], "offsets": [ [ 165, 169 ] ], "normalized": [] }, { "id": "split_0_train_8316_entity", "type": "progene_text", "text": [ "IscU" ], "offsets": [ [ 172, 176 ] ], "normalized": [] }, { "id": "split_0_train_8317_entity", "type": "progene_text", "text": [ "IscA" ], "offsets": [ [ 183, 187 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_5262
split_0_train_5262
[ { "id": "split_0_train_5262_passage", "type": "progene_text", "text": [ "IscR shares amino acid similarity with MarA , a member of the MarA / SoxS / Rob family of transcription factors ." ], "offsets": [ [ 0, 113 ] ] } ]
[ { "id": "split_0_train_8318_entity", "type": "progene_text", "text": [ "IscR" ], "offsets": [ [ 0, 4 ] ], "normalized": [] }, { "id": "split_0_train_8319_entity", "type": "progene_text", "text": [ "MarA" ], "offsets": [ [ 39, 43 ] ], "normalized": [] }, { "id": "split_0_train_8320_entity", "type": "progene_text", "text": [ "MarA / SoxS / Rob family" ], "offsets": [ [ 62, 86 ] ], "normalized": [] }, { "id": "split_0_train_8321_entity", "type": "progene_text", "text": [ "transcription factors" ], "offsets": [ [ 90, 111 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_5263
split_0_train_5263
[ { "id": "split_0_train_5263_passage", "type": "progene_text", "text": [ "In this study , we found that IscR functions as a repressor of the iscRSUA operon , because strains deleted for iscR have increased expression of this operon ." ], "offsets": [ [ 0, 159 ] ] } ]
[ { "id": "split_0_train_8322_entity", "type": "progene_text", "text": [ "IscR" ], "offsets": [ [ 30, 34 ] ], "normalized": [] }, { "id": "split_0_train_8323_entity", "type": "progene_text", "text": [ "iscRSUA operon" ], "offsets": [ [ 67, 81 ] ], "normalized": [] }, { "id": "split_0_train_8324_entity", "type": "progene_text", "text": [ "iscR" ], "offsets": [ [ 112, 116 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_5264
split_0_train_5264
[ { "id": "split_0_train_5264_passage", "type": "progene_text", "text": [ "In addition , in vitro transcription reactions established a direct role for IscR in repression of the iscR promoter ." ], "offsets": [ [ 0, 118 ] ] } ]
[ { "id": "split_0_train_8325_entity", "type": "progene_text", "text": [ "IscR" ], "offsets": [ [ 77, 81 ] ], "normalized": [] }, { "id": "split_0_train_8326_entity", "type": "progene_text", "text": [ "iscR" ], "offsets": [ [ 103, 107 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_5265
split_0_train_5265
[ { "id": "split_0_train_5265_passage", "type": "progene_text", "text": [ "Analysis of IscR by electron paramagnetic resonance showed that the anaerobically isolated protein contains a [2Fe-2S](1+ ) cluster ." ], "offsets": [ [ 0, 133 ] ] } ]
[ { "id": "split_0_train_8327_entity", "type": "progene_text", "text": [ "IscR" ], "offsets": [ [ 12, 16 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_5266
split_0_train_5266
[ { "id": "split_0_train_5266_passage", "type": "progene_text", "text": [ "The Fe-S cluster appears to be important for IscR function , because repression of iscR expression is significantly reduced in strains containing null mutations of the Fe-S cluster assembly genes iscS or hscA ." ], "offsets": [ [ 0, 210 ] ] } ]
[ { "id": "split_0_train_8328_entity", "type": "progene_text", "text": [ "IscR" ], "offsets": [ [ 45, 49 ] ], "normalized": [] }, { "id": "split_0_train_8329_entity", "type": "progene_text", "text": [ "iscR" ], "offsets": [ [ 83, 87 ] ], "normalized": [] }, { "id": "split_0_train_8330_entity", "type": "progene_text", "text": [ "iscS" ], "offsets": [ [ 196, 200 ] ], "normalized": [] }, { "id": "split_0_train_8331_entity", "type": "progene_text", "text": [ "hscA" ], "offsets": [ [ 204, 208 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_5267
split_0_train_5267
[ { "id": "split_0_train_5267_passage", "type": "progene_text", "text": [ "The finding that IscR activity is decreased in strain backgrounds in which Fe-S cluster assembly is impaired suggests that this protein may be part of a novel autoregulatory mechanism that senses the Fe-S cluster assembly status of cells ." ], "offsets": [ [ 0, 239 ] ] } ]
[ { "id": "split_0_train_8332_entity", "type": "progene_text", "text": [ "IscR" ], "offsets": [ [ 17, 21 ] ], "normalized": [] } ]
[]
[]
[]
split_0_train_5268
split_0_train_5268
[ { "id": "split_0_train_5268_passage", "type": "progene_text", "text": [ "Identification of novel Plasmodium gallinaceum zygote - and ookinete - expressed proteins as targets for blocking malaria transmission ." ], "offsets": [ [ 0, 136 ] ] } ]
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[]
[]
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split_0_train_5269
split_0_train_5269
[ { "id": "split_0_train_5269_passage", "type": "progene_text", "text": [ "The development of transmission - blocking vaccines is one approach to malaria control ." ], "offsets": [ [ 0, 88 ] ] } ]
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[]
[]
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split_0_train_5270
split_0_train_5270
[ { "id": "split_0_train_5270_passage", "type": "progene_text", "text": [ "To identify novel Plasmodium zygote - and ookinete - secreted proteins as targets of blocking malaria transmission , monoclonal antibodies ( MAbs ) were produced against parasite - secreted proteins found in Plasmodium gallinaceum ookinete culture supernatants ." ], "offsets": [ [ 0, 262 ] ] } ]
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[]
[]
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split_0_train_5271
split_0_train_5271
[ { "id": "split_0_train_5271_passage", "type": "progene_text", "text": [ "Four MAbs-1A6 , 2A5 , 2B5 , and 4B6 - were identified that bound to P. gallinaceum zygotes and ookinetes in diverse patterns in terms of spatial localization on parasites , time course of antigen expression , and Western immunoblot patterns ." ], "offsets": [ [ 0, 242 ] ] } ]
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[]
[]
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split_0_train_5272
split_0_train_5272
[ { "id": "split_0_train_5272_passage", "type": "progene_text", "text": [ "MAbs 2A5 and 4B6 recognized more than one protein band as detected by Western immunoblot of P. gallinaceum ookinete supernatants ." ], "offsets": [ [ 0, 130 ] ] } ]
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[]
[]
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split_0_train_5273
split_0_train_5273
[ { "id": "split_0_train_5273_passage", "type": "progene_text", "text": [ "Beginning at 0 h postfertilization , MAb 2A5 recognized a diverse set of antigens ; at 10 h postfertilization , MAb 4B6 recognized several antigens as well ." ], "offsets": [ [ 0, 157 ] ] } ]
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[]
[]
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split_0_train_5274
split_0_train_5274
[ { "id": "split_0_train_5274_passage", "type": "progene_text", "text": [ "MAb 1A6 recognized a single approximately 17 - kDa protein , and 2B5 recognized a single approximately 32 - kDa protein at 15 h postfertilization ." ], "offsets": [ [ 0, 147 ] ] } ]
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split_0_train_5275
split_0_train_5275
[ { "id": "split_0_train_5275_passage", "type": "progene_text", "text": [ "In membrane feeding assays to assess the effect of these MAbs on P. gallinaceum infectivity for Aedes aegypti mosquitoes , the addition of MAbs 1A6 and 2B5 to infectious blood meals significantly inhibited oocyst development in the mosquito midgut ." ], "offsets": [ [ 0, 249 ] ] } ]
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[]
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split_0_train_5276
split_0_train_5276
[ { "id": "split_0_train_5276_passage", "type": "progene_text", "text": [ "In contrast , MAb 2A5 seemed to enhance infectivity ." ], "offsets": [ [ 0, 53 ] ] } ]
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[]
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split_0_train_5277
split_0_train_5277
[ { "id": "split_0_train_5277_passage", "type": "progene_text", "text": [ "These results demonstrate that Plasmodium ookinetes secrete proteins ( in addition to previously characterized chitinases ) that may be targets for blocking malaria transmission ." ], "offsets": [ [ 0, 179 ] ] } ]
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split_0_train_5278
split_0_train_5278
[ { "id": "split_0_train_5278_passage", "type": "progene_text", "text": [ "Future investigation of ookinete - secreted neutralization - sensitive molecules should provide valuable insight into mechanisms by which ookinetes exit the blood meal , penetrate and transverse the peritrophic matrix , and invade the mosquito midgut epithelium ." ], "offsets": [ [ 0, 263 ] ] } ]
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[]
[]
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split_0_train_5279
split_0_train_5279
[ { "id": "split_0_train_5279_passage", "type": "progene_text", "text": [ "Posterior fossa and arterial abnormalities in patients with facial capillary haemangioma : presumed incomplete phenotypic expression of PHACES syndrome ." ], "offsets": [ [ 0, 153 ] ] } ]
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split_0_train_5280
split_0_train_5280
[ { "id": "split_0_train_5280_passage", "type": "progene_text", "text": [ "We report on the neuroradiological studies performed on three infants with capillary haemangioma ( CH ) of the head and neck with associated posterior fossa and arterial abnormalities ." ], "offsets": [ [ 0, 185 ] ] } ]
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[]
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split_0_train_5281
split_0_train_5281
[ { "id": "split_0_train_5281_passage", "type": "progene_text", "text": [ "Posterior fossa malformations were represented by cerebellar hemispheric and vermian hypoplasia and cerebellar cortical dysgenesis , whereas arterial anomalies included bilateral agenesis , kinking , and looping of the internal carotid arteries ." ], "offsets": [ [ 0, 246 ] ] } ]
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split_0_train_5282
split_0_train_5282
[ { "id": "split_0_train_5282_passage", "type": "progene_text", "text": [ "One patient had marked exophthalmos due to intraorbital CH ." ], "offsets": [ [ 0, 60 ] ] } ]
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[]
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split_0_train_5283
split_0_train_5283
[ { "id": "split_0_train_5283_passage", "type": "progene_text", "text": [ "We suggest that these patients had an incomplete phenotypic expression of PHACES syndrome , a vascular phakomatosis characterised by the variable association of posterior fossa malformations , CH , arterial anomalies , coarctation of the aorta and cardiac defects , eye abnormalities , and sternal and medioventral defects ." ], "offsets": [ [ 0, 324 ] ] } ]
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[]
[]
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split_0_train_5284
split_0_train_5284
[ { "id": "split_0_train_5284_passage", "type": "progene_text", "text": [ "Evidence suggests that PHACES syndrome is not a random association but a true phakomatosis ; further studies are awaited to shed light on a possible genetic background ." ], "offsets": [ [ 0, 169 ] ] } ]
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split_0_train_5285
split_0_train_5285
[ { "id": "split_0_train_5285_passage", "type": "progene_text", "text": [ "The phenotypic spectrum is broad and still largely unexplored , and precise diagnostic criteria have not yet been identified ." ], "offsets": [ [ 0, 126 ] ] } ]
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[]
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split_0_train_5286
split_0_train_5286
[ { "id": "split_0_train_5286_passage", "type": "progene_text", "text": [ "[ Repetitious sorption of phenol to organobentonites from water ]" ], "offsets": [ [ 0, 65 ] ] } ]
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[]
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split_0_train_5287
split_0_train_5287
[ { "id": "split_0_train_5287_passage", "type": "progene_text", "text": [ "The properties and mechanisms for repetitious sorption of phenol to organobentonites from water were studied ." ], "offsets": [ [ 0, 110 ] ] } ]
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split_0_train_5288
split_0_train_5288
[ { "id": "split_0_train_5288_passage", "type": "progene_text", "text": [ "Results showed that organobentonites could be used to sorb phenol from water many times with high removal rates ." ], "offsets": [ [ 0, 113 ] ] } ]
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[]
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split_0_train_5289
split_0_train_5289
[ { "id": "split_0_train_5289_passage", "type": "progene_text", "text": [ "The sorption capacities of three single - cation organobentonites were 120 CTMAB - bentonites > 120 CPC - bentonites > 120 DTMAB - bentonites , when the original concentration of phenol was 1000 mg / L ." ], "offsets": [ [ 0, 203 ] ] } ]
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[]
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split_0_train_5290
split_0_train_5290
[ { "id": "split_0_train_5290_passage", "type": "progene_text", "text": [ "The sorption mechanisms changed from adsorption to partition in the process of repetitious sorption ." ], "offsets": [ [ 0, 101 ] ] } ]
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split_0_train_5291
split_0_train_5291
[ { "id": "split_0_train_5291_passage", "type": "progene_text", "text": [ "Sorption of phenol to CPC - bentonites could bring synergic sorption ." ], "offsets": [ [ 0, 70 ] ] } ]
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[]
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split_0_train_5292
split_0_train_5292
[ { "id": "split_0_train_5292_passage", "type": "progene_text", "text": [ "The distribution coefficience ( Kp ) were related to the quantities of phenol on CPC-bentonites , while the distribution coefficience of phenol on CTMAB-bentonites and DTMAB - bentonite were constant ." ], "offsets": [ [ 0, 201 ] ] } ]
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split_0_train_5293
split_0_train_5293
[ { "id": "split_0_train_5293_passage", "type": "progene_text", "text": [ "Hypofractionated and accelerated radiotherapy with cytoprotection ( HypoARC ) : a short , safe , and effective postoperative regimen for high - risk breast cancer patients ." ], "offsets": [ [ 0, 173 ] ] } ]
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split_0_train_5294
split_0_train_5294
[ { "id": "split_0_train_5294_passage", "type": "progene_text", "text": [ "PURPOSE :" ], "offsets": [ [ 0, 9 ] ] } ]
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[]
[]
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split_0_train_5295
split_0_train_5295
[ { "id": "split_0_train_5295_passage", "type": "progene_text", "text": [ "Although the role of radiotherapy ( RT ) after mastectomy in reducing the local relapse rate is well established , its impact on overall survival is strongly questioned ." ], "offsets": [ [ 0, 170 ] ] } ]
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[]
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split_0_train_5296
split_0_train_5296
[ { "id": "split_0_train_5296_passage", "type": "progene_text", "text": [ "Up to 70 % of patients will not benefit from additional RT , and a \" wait and see \" policy is often adopted ." ], "offsets": [ [ 0, 109 ] ] } ]
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[]
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split_0_train_5297
split_0_train_5297
[ { "id": "split_0_train_5297_passage", "type": "progene_text", "text": [ "Establishment of short , still safe , and effective RT regimens would render adjunctive radiotherapy more appealing ." ], "offsets": [ [ 0, 117 ] ] } ]
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split_0_train_5298
split_0_train_5298
[ { "id": "split_0_train_5298_passage", "type": "progene_text", "text": [ "We evaluated the toxicity and efficacy of a Hypofractionated and intensively Accelerated RT regimen supported with amifostine Cytoprotection ( HypoARC ) in a cohort of 72 high - risk breast cancer patients treated with modified mastectomy or conservative surgery and FEC ( 5-fluorouracil / epirubicin / cyclophosphamide ) chemotherapy ." ], "offsets": [ [ 0, 336 ] ] } ]
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split_0_train_5299
split_0_train_5299
[ { "id": "split_0_train_5299_passage", "type": "progene_text", "text": [ "PATIENTS AND METHODS :" ], "offsets": [ [ 0, 22 ] ] } ]
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[]
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