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|---|---|---|---|---|---|---|
split_0_train_5300
|
split_0_train_5300
|
[
{
"id": "split_0_train_5300_passage",
"type": "progene_text",
"text": [
"A high dose of amifostine , 1,000 mg , was given as a 5 - min i.v. infusion before each of the 12 consecutive fractions of RT ( 4 x 3.5 Gy / fraction and 8 x 4 Gy / fraction , 1 fraction / day , 5 fractions / week ) ."
],
"offsets": [
[
0,
217
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5301
|
split_0_train_5301
|
[
{
"id": "split_0_train_5301_passage",
"type": "progene_text",
"text": [
"The breast or chest wall , as well as supraclavicular and axillary area , was included in the RT fields ."
],
"offsets": [
[
0,
105
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5302
|
split_0_train_5302
|
[
{
"id": "split_0_train_5302_passage",
"type": "progene_text",
"text": [
"The follow - up of patients ranged from 18 to 42 months ( median , 28 months ) ."
],
"offsets": [
[
0,
80
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5303
|
split_0_train_5303
|
[
{
"id": "split_0_train_5303_passage",
"type": "progene_text",
"text": [
"Alkaline phosphatase ( AF ) expression was assessed immunohistochemically in normal and cancerous breast tissues ."
],
"offsets": [
[
0,
114
]
]
}
] |
[
{
"id": "split_0_train_8333_entity",
"type": "progene_text",
"text": [
"Alkaline phosphatase"
],
"offsets": [
[
0,
20
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5304
|
split_0_train_5304
|
[
{
"id": "split_0_train_5304_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5305
|
split_0_train_5305
|
[
{
"id": "split_0_train_5305_passage",
"type": "progene_text",
"text": [
"Ninety-two percent of patients successfully completed the regimen , the only side effects being mild nausea and asthenia ."
],
"offsets": [
[
0,
122
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5306
|
split_0_train_5306
|
[
{
"id": "split_0_train_5306_passage",
"type": "progene_text",
"text": [
"In 7 % of patients , amifostine was interrupted because of a rash / fever reaction ."
],
"offsets": [
[
0,
84
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5307
|
split_0_train_5307
|
[
{
"id": "split_0_train_5307_passage",
"type": "progene_text",
"text": [
"A dramatic reduction in acute skin toxicity was noted ( p < 0.0001 ) ."
],
"offsets": [
[
0,
70
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5308
|
split_0_train_5308
|
[
{
"id": "split_0_train_5308_passage",
"type": "progene_text",
"text": [
"Acute pneumonitis , as well as late toxicity in breast , chest wall , axillary , and lung tissue , was lower with the HypoARC regimen , although not significantly , than with the standard fractionation regimen used to treat two matched control cohorts ."
],
"offsets": [
[
0,
253
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5309
|
split_0_train_5309
|
[
{
"id": "split_0_train_5309_passage",
"type": "progene_text",
"text": [
"Both HypoARC and standard RT significantly reduce the local relapse rate ( p < 0.0001 ) , although the local relapse - free and overall survival times were marginally better for the HypoARC group of patients ( p > 0.09 ) ."
],
"offsets": [
[
0,
222
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5310
|
split_0_train_5310
|
[
{
"id": "split_0_train_5310_passage",
"type": "progene_text",
"text": [
"AF showed a mixed nuclear / cytoplasmic pattern of expression in the epithelial , endothelial , and stromal component of the normal breast and benign lesions , whereas an impressive loss of AF expression was noted in in situ and invasive breast cancer and tumoral stroma ."
],
"offsets": [
[
0,
272
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5311
|
split_0_train_5311
|
[
{
"id": "split_0_train_5311_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5312
|
split_0_train_5312
|
[
{
"id": "split_0_train_5312_passage",
"type": "progene_text",
"text": [
"The HypoARC regimen is convenient for both patients and radiotherapy departments ."
],
"offsets": [
[
0,
82
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5313
|
split_0_train_5313
|
[
{
"id": "split_0_train_5313_passage",
"type": "progene_text",
"text": [
"The regimen is well tolerated and shows a significantly better profile in terms of early toxicity ; a reduced rate of late sequel may be expected ."
],
"offsets": [
[
0,
147
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5314
|
split_0_train_5314
|
[
{
"id": "split_0_train_5314_passage",
"type": "progene_text",
"text": [
"The local relapse rate is as low as that expected from conventional RT ."
],
"offsets": [
[
0,
72
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5315
|
split_0_train_5315
|
[
{
"id": "split_0_train_5315_passage",
"type": "progene_text",
"text": [
"The absence of AF expression in cancer cells and tumoral stroma is probably a major reason for the selective protection of normal breast tissue by amifostine ."
],
"offsets": [
[
0,
159
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5316
|
split_0_train_5316
|
[
{
"id": "split_0_train_5316_passage",
"type": "progene_text",
"text": [
"Role of cyclin - dependent kinase inhibitors in the growth arrest at senescence in human prostate epithelial and uroepithelial cells ."
],
"offsets": [
[
0,
134
]
]
}
] |
[
{
"id": "split_0_train_8334_entity",
"type": "progene_text",
"text": [
"cyclin - dependent kinase"
],
"offsets": [
[
8,
33
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5317
|
split_0_train_5317
|
[
{
"id": "split_0_train_5317_passage",
"type": "progene_text",
"text": [
"Cellular senescence has been proposed to be an in vitro and in vivo block that cells must overcome in order to immortalize and become tumorigenic ."
],
"offsets": [
[
0,
147
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5318
|
split_0_train_5318
|
[
{
"id": "split_0_train_5318_passage",
"type": "progene_text",
"text": [
"To characterize these pathways , we focused on changes in the cyclin - dependent kinase inhibitors and their binding partners that underlie the cell cycle arrest at senescence ."
],
"offsets": [
[
0,
177
]
]
}
] |
[
{
"id": "split_0_train_8335_entity",
"type": "progene_text",
"text": [
"cyclin - dependent kinase"
],
"offsets": [
[
62,
87
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5319
|
split_0_train_5319
|
[
{
"id": "split_0_train_5319_passage",
"type": "progene_text",
"text": [
"As a model , we utilized normal human prostate epithelial cell ( HPEC ) and human uroepithelial cell ( HUC ) cultures ."
],
"offsets": [
[
0,
119
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5320
|
split_0_train_5320
|
[
{
"id": "split_0_train_5320_passage",
"type": "progene_text",
"text": [
"After 30 - 40 population doublings cells became growth - arrested in G0/1 with a threefold decrease in Cdk2 - associated activity , a point defined as pre - senescence ."
],
"offsets": [
[
0,
169
]
]
}
] |
[
{
"id": "split_0_train_8336_entity",
"type": "progene_text",
"text": [
"G0/1"
],
"offsets": [
[
69,
73
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],
"normalized": []
},
{
"id": "split_0_train_8337_entity",
"type": "progene_text",
"text": [
"Cdk2"
],
"offsets": [
[
103,
107
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5321
|
split_0_train_5321
|
[
{
"id": "split_0_train_5321_passage",
"type": "progene_text",
"text": [
"Temporally following this growth arrest , the cells develop a senescence morphology and express senescence - associated beta-galactosidase ( SA-beta-gal ) ."
],
"offsets": [
[
0,
156
]
]
}
] |
[
{
"id": "split_0_train_8338_entity",
"type": "progene_text",
"text": [
"beta-galactosidase"
],
"offsets": [
[
120,
138
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5322
|
split_0_train_5322
|
[
{
"id": "split_0_train_5322_passage",
"type": "progene_text",
"text": [
"Levels of p16 ( INK4a ) and p57 ( KIP2 ) rise in HUCs during progressive passages , whereas only p16 increases in HPEC cultures ."
],
"offsets": [
[
0,
129
]
]
}
] |
[
{
"id": "split_0_train_8339_entity",
"type": "progene_text",
"text": [
"p16 ( INK4a )"
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"offsets": [
[
10,
23
]
],
"normalized": []
},
{
"id": "split_0_train_8340_entity",
"type": "progene_text",
"text": [
"p57 ( KIP2 )"
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"offsets": [
[
28,
40
]
],
"normalized": []
},
{
"id": "split_0_train_8341_entity",
"type": "progene_text",
"text": [
"p16"
],
"offsets": [
[
97,
100
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5323
|
split_0_train_5323
|
[
{
"id": "split_0_train_5323_passage",
"type": "progene_text",
"text": [
"The induced expression of p57 , similar to p16 , produces a senescent - like phenotype ."
],
"offsets": [
[
0,
88
]
]
}
] |
[
{
"id": "split_0_train_8342_entity",
"type": "progene_text",
"text": [
"p57"
],
"offsets": [
[
26,
29
]
],
"normalized": []
},
{
"id": "split_0_train_8343_entity",
"type": "progene_text",
"text": [
"p16"
],
"offsets": [
[
43,
46
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5324
|
split_0_train_5324
|
[
{
"id": "split_0_train_5324_passage",
"type": "progene_text",
"text": [
"pRB , cyclin D , p19 ( INK4d ) and p27 ( KIP1 ) decrease in both cell types ."
],
"offsets": [
[
0,
77
]
]
}
] |
[
{
"id": "split_0_train_8344_entity",
"type": "progene_text",
"text": [
"pRB"
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"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "split_0_train_8345_entity",
"type": "progene_text",
"text": [
"cyclin D"
],
"offsets": [
[
6,
14
]
],
"normalized": []
},
{
"id": "split_0_train_8346_entity",
"type": "progene_text",
"text": [
"p19 ( INK4d )"
],
"offsets": [
[
17,
30
]
],
"normalized": []
},
{
"id": "split_0_train_8347_entity",
"type": "progene_text",
"text": [
"p27 ( KIP1 )"
],
"offsets": [
[
35,
47
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5325
|
split_0_train_5325
|
[
{
"id": "split_0_train_5325_passage",
"type": "progene_text",
"text": [
"We find that p53 , p21 ( CIP1 ) and p15 ( INK4b ) are transiently elevated in HPECs and HUCs at the pre - senescent growth arrest , then return to low proliferating levels at terminal senescence ."
],
"offsets": [
[
0,
196
]
]
}
] |
[
{
"id": "split_0_train_8348_entity",
"type": "progene_text",
"text": [
"p53"
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"offsets": [
[
13,
16
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],
"normalized": []
},
{
"id": "split_0_train_8349_entity",
"type": "progene_text",
"text": [
"p21 ( CIP1 )"
],
"offsets": [
[
19,
31
]
],
"normalized": []
},
{
"id": "split_0_train_8350_entity",
"type": "progene_text",
"text": [
"p15 ( INK4b )"
],
"offsets": [
[
36,
49
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5326
|
split_0_train_5326
|
[
{
"id": "split_0_train_5326_passage",
"type": "progene_text",
"text": [
"Analysis of p53 , p21 ( CIP1 ) , p15 ( INK4b ) , p16 ( INK4a ) , and p57 ( KIP2 ) reveals altered expression in immortalized , non - tumorigenic HPV16 E6 and E7 prostate lines and in tumorigenic prostate cancer cells ."
],
"offsets": [
[
0,
218
]
]
}
] |
[
{
"id": "split_0_train_8351_entity",
"type": "progene_text",
"text": [
"p53"
],
"offsets": [
[
12,
15
]
],
"normalized": []
},
{
"id": "split_0_train_8352_entity",
"type": "progene_text",
"text": [
"p21 ( CIP1 )"
],
"offsets": [
[
18,
30
]
],
"normalized": []
},
{
"id": "split_0_train_8353_entity",
"type": "progene_text",
"text": [
"p15 ( INK4b )"
],
"offsets": [
[
33,
46
]
],
"normalized": []
},
{
"id": "split_0_train_8354_entity",
"type": "progene_text",
"text": [
"p16 ( INK4a )"
],
"offsets": [
[
49,
62
]
],
"normalized": []
},
{
"id": "split_0_train_8355_entity",
"type": "progene_text",
"text": [
"p57 ( KIP2 )"
],
"offsets": [
[
69,
81
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5327
|
split_0_train_5327
|
[
{
"id": "split_0_train_5327_passage",
"type": "progene_text",
"text": [
"These results indicate : (i) the existence of a subset of growth inhibiting genes elevated at the onset of the senescence , (ii) a distinct class of genes involved in the maintenance of senescence , and (iii) the frequent inactivation of these pathways during immortalization ."
],
"offsets": [
[
0,
277
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5328
|
split_0_train_5328
|
[
{
"id": "split_0_train_5328_passage",
"type": "progene_text",
"text": [
"Contribution of body surface mapping to clinical outcome after surgical ablation of postinfarction ventricular tachycardia ."
],
"offsets": [
[
0,
124
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5329
|
split_0_train_5329
|
[
{
"id": "split_0_train_5329_passage",
"type": "progene_text",
"text": [
"This article investigates the influence of body surface mapping on outcome of ventricular antiarrhythmic surgery ."
],
"offsets": [
[
0,
114
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5330
|
split_0_train_5330
|
[
{
"id": "split_0_train_5330_passage",
"type": "progene_text",
"text": [
"Preoperative mapping is advocated to optimize map - guided antiarrhythmic surgery of postinfarction ventricular tachycardia ."
],
"offsets": [
[
0,
125
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5331
|
split_0_train_5331
|
[
{
"id": "split_0_train_5331_passage",
"type": "progene_text",
"text": [
"We sequentially analyzed the results of catheter activation sequence mapping , body surface mapping , and intraoperative multielectrode mapping in 54 patients and made a comparison with 30 control patients ( group B ) in whom catheter activation sequence mapping was omitted ."
],
"offsets": [
[
0,
276
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5332
|
split_0_train_5332
|
[
{
"id": "split_0_train_5332_passage",
"type": "progene_text",
"text": [
"Endpoints were actuarial survival , freedom of arrhythmia , and comparability of the localisation of sites of ventricular tachycardia origin ."
],
"offsets": [
[
0,
142
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5333
|
split_0_train_5333
|
[
{
"id": "split_0_train_5333_passage",
"type": "progene_text",
"text": [
"A total of 128 morphologically different monomorphic sustained ventricular tachycardias were mapped in group A ."
],
"offsets": [
[
0,
112
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5334
|
split_0_train_5334
|
[
{
"id": "split_0_train_5334_passage",
"type": "progene_text",
"text": [
"In group A , 87 ventricular tachycardias were mapped preoperatively with body surface mapping and 30 ventricular tachycardias with catheter activation sequence mapping ."
],
"offsets": [
[
0,
169
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5335
|
split_0_train_5335
|
[
{
"id": "split_0_train_5335_passage",
"type": "progene_text",
"text": [
"In 19 of 24 ventricular tachycardias ( 79 % ) that were localized with both mapping methods the ventricular tachycardia exit site was similar ."
],
"offsets": [
[
0,
143
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5336
|
split_0_train_5336
|
[
{
"id": "split_0_train_5336_passage",
"type": "progene_text",
"text": [
"In - hospital death was 1 of 85 ( 1.2 % ) ."
],
"offsets": [
[
0,
43
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5337
|
split_0_train_5337
|
[
{
"id": "split_0_train_5337_passage",
"type": "progene_text",
"text": [
"Actuarial freedom from ventricular arrhythmias at 4 - year follow - up was 74.1 +/- 6.0 % in group A vs. 90.0 +/- 5.5 % in group B ( P = .10 ) ."
],
"offsets": [
[
0,
144
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5338
|
split_0_train_5338
|
[
{
"id": "split_0_train_5338_passage",
"type": "progene_text",
"text": [
"In group A 14 of 54 patients died ( 29.6 % ) , whereas 4 of 30 patients ( 13.3 % ) died in group B ( P = .09 ) ."
],
"offsets": [
[
0,
112
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5339
|
split_0_train_5339
|
[
{
"id": "split_0_train_5339_passage",
"type": "progene_text",
"text": [
"Arrhythmia freedom and survival is as good in patients mapped with body surface mapping only as in patients mapped with body surface mapping and catheter activation sequence mapping ."
],
"offsets": [
[
0,
183
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5340
|
split_0_train_5340
|
[
{
"id": "split_0_train_5340_passage",
"type": "progene_text",
"text": [
"Genetic profile of 22 pancreatic carcinoma cell lines ."
],
"offsets": [
[
0,
55
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5341
|
split_0_train_5341
|
[
{
"id": "split_0_train_5341_passage",
"type": "progene_text",
"text": [
"Analysis of K-ras , p53 , p16 and DPC4 / Smad4 ."
],
"offsets": [
[
0,
48
]
]
}
] |
[
{
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"K-ras"
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12,
17
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},
{
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"p53"
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20,
23
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},
{
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"p16"
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26,
29
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},
{
"id": "split_0_train_8359_entity",
"type": "progene_text",
"text": [
"DPC4"
],
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[
34,
38
]
],
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},
{
"id": "split_0_train_8360_entity",
"type": "progene_text",
"text": [
"Smad4"
],
"offsets": [
[
41,
46
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5342
|
split_0_train_5342
|
[
{
"id": "split_0_train_5342_passage",
"type": "progene_text",
"text": [
"The K-ras , p53 , p16 and DPC4 genes are among those most frequently altered in pancreatic ductal carcinoma ."
],
"offsets": [
[
0,
109
]
]
}
] |
[
{
"id": "split_0_train_8361_entity",
"type": "progene_text",
"text": [
"K-ras"
],
"offsets": [
[
4,
9
]
],
"normalized": []
},
{
"id": "split_0_train_8362_entity",
"type": "progene_text",
"text": [
"p53"
],
"offsets": [
[
12,
15
]
],
"normalized": []
},
{
"id": "split_0_train_8363_entity",
"type": "progene_text",
"text": [
"p16"
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[
18,
21
]
],
"normalized": []
},
{
"id": "split_0_train_8364_entity",
"type": "progene_text",
"text": [
"DPC4"
],
"offsets": [
[
26,
30
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5343
|
split_0_train_5343
|
[
{
"id": "split_0_train_5343_passage",
"type": "progene_text",
"text": [
"We analyzed 22 cell lines for alterations in these genes by direct sequence analysis and methylation - specific polymerase chain reaction ."
],
"offsets": [
[
0,
139
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5344
|
split_0_train_5344
|
[
{
"id": "split_0_train_5344_passage",
"type": "progene_text",
"text": [
"These cell lines showed mutations in K-ras and p53 at frequencies of 91 % and 95 % , respectively ."
],
"offsets": [
[
0,
99
]
]
}
] |
[
{
"id": "split_0_train_8365_entity",
"type": "progene_text",
"text": [
"K-ras"
],
"offsets": [
[
37,
42
]
],
"normalized": []
},
{
"id": "split_0_train_8366_entity",
"type": "progene_text",
"text": [
"p53"
],
"offsets": [
[
47,
50
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5345
|
split_0_train_5345
|
[
{
"id": "split_0_train_5345_passage",
"type": "progene_text",
"text": [
"Alterations in p16INK4a were found in all cases and included nine homozygous deletions , seven mutations and promoter methylation in six cases ."
],
"offsets": [
[
0,
144
]
]
}
] |
[
{
"id": "split_0_train_8367_entity",
"type": "progene_text",
"text": [
"p16INK4a"
],
"offsets": [
[
15,
23
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5346
|
split_0_train_5346
|
[
{
"id": "split_0_train_5346_passage",
"type": "progene_text",
"text": [
"Eight cell lines ( 36 % ) had an alteration of DPC4 , including one mutation and seven homozygous deletions ."
],
"offsets": [
[
0,
109
]
]
}
] |
[
{
"id": "split_0_train_8368_entity",
"type": "progene_text",
"text": [
"DPC4"
],
"offsets": [
[
47,
51
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5347
|
split_0_train_5347
|
[
{
"id": "split_0_train_5347_passage",
"type": "progene_text",
"text": [
"The most typical mutational profile involved K-ras , p53 , and p16INK4a , concurrently aberrated in 20 cases ( 91 % ) ."
],
"offsets": [
[
0,
119
]
]
}
] |
[
{
"id": "split_0_train_8369_entity",
"type": "progene_text",
"text": [
"K-ras"
],
"offsets": [
[
45,
50
]
],
"normalized": []
},
{
"id": "split_0_train_8370_entity",
"type": "progene_text",
"text": [
"p53"
],
"offsets": [
[
53,
56
]
],
"normalized": []
},
{
"id": "split_0_train_8371_entity",
"type": "progene_text",
"text": [
"p16INK4a"
],
"offsets": [
[
63,
71
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5348
|
split_0_train_5348
|
[
{
"id": "split_0_train_5348_passage",
"type": "progene_text",
"text": [
"Eight cell lines had alterations in all four genes ."
],
"offsets": [
[
0,
52
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5349
|
split_0_train_5349
|
[
{
"id": "split_0_train_5349_passage",
"type": "progene_text",
"text": [
"Inactivation of DPC4 was always accompanied by alteration of all of the other three genes ."
],
"offsets": [
[
0,
91
]
]
}
] |
[
{
"id": "split_0_train_8372_entity",
"type": "progene_text",
"text": [
"DPC4"
],
"offsets": [
[
16,
20
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5350
|
split_0_train_5350
|
[
{
"id": "split_0_train_5350_passage",
"type": "progene_text",
"text": [
"This comprehensive data regarding the cumulative genetic alterations in pancreatic carcinoma cell lines will be of great value for studies involving drug sensitivity or resistance that may be associated with inactivation of a particular gene or molecular pathway ."
],
"offsets": [
[
0,
264
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5351
|
split_0_train_5351
|
[
{
"id": "split_0_train_5351_passage",
"type": "progene_text",
"text": [
"Rapsyn mutations in humans cause endplate acetylcholine - receptor deficiency and myasthenic syndrome ."
],
"offsets": [
[
0,
103
]
]
}
] |
[
{
"id": "split_0_train_8373_entity",
"type": "progene_text",
"text": [
"Rapsyn"
],
"offsets": [
[
0,
6
]
],
"normalized": []
},
{
"id": "split_0_train_8374_entity",
"type": "progene_text",
"text": [
"acetylcholine - receptor"
],
"offsets": [
[
42,
66
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5352
|
split_0_train_5352
|
[
{
"id": "split_0_train_5352_passage",
"type": "progene_text",
"text": [
"Congenital myasthenic syndromes ( CMSs ) stem from genetic defects in endplate ( EP ) - specific presynaptic , synaptic , and postsynaptic proteins ."
],
"offsets": [
[
0,
149
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5353
|
split_0_train_5353
|
[
{
"id": "split_0_train_5353_passage",
"type": "progene_text",
"text": [
"The postsynaptic CMSs identified to date stem from a deficiency or kinetic abnormality of the acetylcholine receptor ( AChR ) ."
],
"offsets": [
[
0,
127
]
]
}
] |
[
{
"id": "split_0_train_8375_entity",
"type": "progene_text",
"text": [
"acetylcholine receptor"
],
"offsets": [
[
94,
116
]
],
"normalized": []
},
{
"id": "split_0_train_8376_entity",
"type": "progene_text",
"text": [
"AChR"
],
"offsets": [
[
119,
123
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5354
|
split_0_train_5354
|
[
{
"id": "split_0_train_5354_passage",
"type": "progene_text",
"text": [
"All CMSs with a kinetic abnormality of AChR , as well as many CMSs with a deficiency of AChR , have been traced to mutations in AChR - subunit genes ."
],
"offsets": [
[
0,
150
]
]
}
] |
[
{
"id": "split_0_train_8377_entity",
"type": "progene_text",
"text": [
"AChR"
],
"offsets": [
[
39,
43
]
],
"normalized": []
},
{
"id": "split_0_train_8378_entity",
"type": "progene_text",
"text": [
"AChR"
],
"offsets": [
[
88,
92
]
],
"normalized": []
},
{
"id": "split_0_train_8379_entity",
"type": "progene_text",
"text": [
"AChR"
],
"offsets": [
[
128,
132
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5355
|
split_0_train_5355
|
[
{
"id": "split_0_train_5355_passage",
"type": "progene_text",
"text": [
"However , in a subset of patients with EP AChR deficiency , the genetic defect has remained elusive ."
],
"offsets": [
[
0,
101
]
]
}
] |
[
{
"id": "split_0_train_8380_entity",
"type": "progene_text",
"text": [
"AChR"
],
"offsets": [
[
42,
46
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5356
|
split_0_train_5356
|
[
{
"id": "split_0_train_5356_passage",
"type": "progene_text",
"text": [
"Rapsyn , a 43 - kDa postsynaptic protein , plays an essential role in the clustering of AChR at the EP ."
],
"offsets": [
[
0,
104
]
]
}
] |
[
{
"id": "split_0_train_8381_entity",
"type": "progene_text",
"text": [
"Rapsyn"
],
"offsets": [
[
0,
6
]
],
"normalized": []
},
{
"id": "split_0_train_8382_entity",
"type": "progene_text",
"text": [
"AChR"
],
"offsets": [
[
88,
92
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5357
|
split_0_train_5357
|
[
{
"id": "split_0_train_5357_passage",
"type": "progene_text",
"text": [
"Seven tetratricopeptide repeats ( TPRs ) of rapsyn subserve self - association , a coiled - coil domain binds to AChR , and a RING - H2 domain associates with beta-dystroglycan and links rapsyn to the subsynaptic cytoskeleton ."
],
"offsets": [
[
0,
227
]
]
}
] |
[
{
"id": "split_0_train_8383_entity",
"type": "progene_text",
"text": [
"rapsyn"
],
"offsets": [
[
44,
50
]
],
"normalized": []
},
{
"id": "split_0_train_8384_entity",
"type": "progene_text",
"text": [
"AChR"
],
"offsets": [
[
113,
117
]
],
"normalized": []
},
{
"id": "split_0_train_8385_entity",
"type": "progene_text",
"text": [
"beta-dystroglycan"
],
"offsets": [
[
159,
176
]
],
"normalized": []
},
{
"id": "split_0_train_8386_entity",
"type": "progene_text",
"text": [
"rapsyn"
],
"offsets": [
[
187,
193
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5358
|
split_0_train_5358
|
[
{
"id": "split_0_train_5358_passage",
"type": "progene_text",
"text": [
"Rapsyn self - association precedes recruitment of AChR to rapsyn clusters ."
],
"offsets": [
[
0,
75
]
]
}
] |
[
{
"id": "split_0_train_8387_entity",
"type": "progene_text",
"text": [
"Rapsyn"
],
"offsets": [
[
0,
6
]
],
"normalized": []
},
{
"id": "split_0_train_8388_entity",
"type": "progene_text",
"text": [
"AChR"
],
"offsets": [
[
50,
54
]
],
"normalized": []
},
{
"id": "split_0_train_8389_entity",
"type": "progene_text",
"text": [
"rapsyn"
],
"offsets": [
[
58,
64
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5359
|
split_0_train_5359
|
[
{
"id": "split_0_train_5359_passage",
"type": "progene_text",
"text": [
"In four patients with EP AChR deficiency but with no mutations in AChR subunits , we identify three recessive rapsyn mutations : one patient carries L14P in TPR1 and N88K in TPR3 ; two are homozygous for N88K ; and one carries N88K and 553ins5 , which frameshifts in TPR5 ."
],
"offsets": [
[
0,
273
]
]
}
] |
[
{
"id": "split_0_train_8390_entity",
"type": "progene_text",
"text": [
"AChR"
],
"offsets": [
[
25,
29
]
],
"normalized": []
},
{
"id": "split_0_train_8391_entity",
"type": "progene_text",
"text": [
"AChR"
],
"offsets": [
[
66,
70
]
],
"normalized": []
},
{
"id": "split_0_train_8392_entity",
"type": "progene_text",
"text": [
"rapsyn"
],
"offsets": [
[
110,
116
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5360
|
split_0_train_5360
|
[
{
"id": "split_0_train_5360_passage",
"type": "progene_text",
"text": [
"EP studies in each case show decreased staining for rapsyn and AChR , as well as impaired postsynaptic morphological development ."
],
"offsets": [
[
0,
130
]
]
}
] |
[
{
"id": "split_0_train_8393_entity",
"type": "progene_text",
"text": [
"rapsyn"
],
"offsets": [
[
52,
58
]
],
"normalized": []
},
{
"id": "split_0_train_8394_entity",
"type": "progene_text",
"text": [
"AChR"
],
"offsets": [
[
63,
67
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5361
|
split_0_train_5361
|
[
{
"id": "split_0_train_5361_passage",
"type": "progene_text",
"text": [
"Expression studies in HEK cells indicate that none of the mutations hinders rapsyn self - association but that all three diminish coclustering of AChR with rapsyn ."
],
"offsets": [
[
0,
164
]
]
}
] |
[
{
"id": "split_0_train_8395_entity",
"type": "progene_text",
"text": [
"rapsyn"
],
"offsets": [
[
76,
82
]
],
"normalized": []
},
{
"id": "split_0_train_8396_entity",
"type": "progene_text",
"text": [
"AChR"
],
"offsets": [
[
146,
150
]
],
"normalized": []
},
{
"id": "split_0_train_8397_entity",
"type": "progene_text",
"text": [
"rapsyn"
],
"offsets": [
[
156,
162
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5362
|
split_0_train_5362
|
[
{
"id": "split_0_train_5362_passage",
"type": "progene_text",
"text": [
"Physicochemical and biomechanical examination of surfaces of retrieved polyethylene heads from total hip prostheses with rotating polyethylene head system ."
],
"offsets": [
[
0,
156
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5363
|
split_0_train_5363
|
[
{
"id": "split_0_train_5363_passage",
"type": "progene_text",
"text": [
"In order to assess whether hydrodynamic lubrication occurs in total hip prostheses with a rotating polyethylene ( PE ) head system ( R-THP ) , several physicochemical , morphological , and biomechanical tests were carried out ."
],
"offsets": [
[
0,
227
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5364
|
split_0_train_5364
|
[
{
"id": "split_0_train_5364_passage",
"type": "progene_text",
"text": [
"R-THPs have been used in more than 1000 patients since 1970 , and 12 PE heads , retrieved from 10 patients after an average of 24.5 years since total hip arthroplasty ( THA ) , were employed for the tests ."
],
"offsets": [
[
0,
206
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5365
|
split_0_train_5365
|
[
{
"id": "split_0_train_5365_passage",
"type": "progene_text",
"text": [
"The weight - bearing area of the PE surface was light yellow in color and considerably oxidized , but no wear scars were observed ."
],
"offsets": [
[
0,
131
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5366
|
split_0_train_5366
|
[
{
"id": "split_0_train_5366_passage",
"type": "progene_text",
"text": [
"In the non - weight - bearing area , in contrast , discoloration and oxidation were hard to detect ."
],
"offsets": [
[
0,
100
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5367
|
split_0_train_5367
|
[
{
"id": "split_0_train_5367_passage",
"type": "progene_text",
"text": [
"The weight - bearing surface of the PE head became smoother with time after THA , and the friction coefficient did not differ significantly from that of an unused PE head ."
],
"offsets": [
[
0,
172
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5368
|
split_0_train_5368
|
[
{
"id": "split_0_train_5368_passage",
"type": "progene_text",
"text": [
"The radial clearance between head and socket decreased at a temperature of 17 degrees C , which is equivalent to the difference between room temperature and the temperature of the human body ."
],
"offsets": [
[
0,
192
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5369
|
split_0_train_5369
|
[
{
"id": "split_0_train_5369_passage",
"type": "progene_text",
"text": [
"Scanning electron microscopy showed a fine undulating pattern , which suggested that hydrodynamic lubrication could occur in the rotating PE head system ."
],
"offsets": [
[
0,
154
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5370
|
split_0_train_5370
|
[
{
"id": "split_0_train_5370_passage",
"type": "progene_text",
"text": [
"Acinar cells of the pancreas are a target of interleukin-22 ."
],
"offsets": [
[
0,
61
]
]
}
] |
[
{
"id": "split_0_train_8398_entity",
"type": "progene_text",
"text": [
"interleukin-22"
],
"offsets": [
[
45,
59
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5371
|
split_0_train_5371
|
[
{
"id": "split_0_train_5371_passage",
"type": "progene_text",
"text": [
"Interleukin-22 ( IL-22 ) ( also reported as IL-10 - related T cell - derived inducible factor , IL-TIF ) is a recently identified cytokine found to signal through a receptor comprising the class II cytokine receptor family members IL-10Rbeta / CRF2 - 4 and IL-22R ."
],
"offsets": [
[
0,
265
]
]
}
] |
[
{
"id": "split_0_train_8399_entity",
"type": "progene_text",
"text": [
"Interleukin-22"
],
"offsets": [
[
0,
14
]
],
"normalized": []
},
{
"id": "split_0_train_8400_entity",
"type": "progene_text",
"text": [
"IL-22"
],
"offsets": [
[
17,
22
]
],
"normalized": []
},
{
"id": "split_0_train_8401_entity",
"type": "progene_text",
"text": [
"IL-10 - related T cell - derived inducible factor"
],
"offsets": [
[
44,
93
]
],
"normalized": []
},
{
"id": "split_0_train_8402_entity",
"type": "progene_text",
"text": [
"IL-TIF"
],
"offsets": [
[
96,
102
]
],
"normalized": []
},
{
"id": "split_0_train_8403_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
130,
138
]
],
"normalized": []
},
{
"id": "split_0_train_8404_entity",
"type": "progene_text",
"text": [
"class II cytokine receptor family"
],
"offsets": [
[
189,
222
]
],
"normalized": []
},
{
"id": "split_0_train_8405_entity",
"type": "progene_text",
"text": [
"IL-10Rbeta"
],
"offsets": [
[
231,
241
]
],
"normalized": []
},
{
"id": "split_0_train_8406_entity",
"type": "progene_text",
"text": [
"CRF2 - 4"
],
"offsets": [
[
244,
252
]
],
"normalized": []
},
{
"id": "split_0_train_8407_entity",
"type": "progene_text",
"text": [
"IL-22R"
],
"offsets": [
[
257,
263
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5372
|
split_0_train_5372
|
[
{
"id": "split_0_train_5372_passage",
"type": "progene_text",
"text": [
"Previous work has established that IL-10Rbeta , also a component of the IL10R complex , exhibits a broad distribution of mRNA expression ."
],
"offsets": [
[
0,
138
]
]
}
] |
[
{
"id": "split_0_train_8408_entity",
"type": "progene_text",
"text": [
"IL-10Rbeta"
],
"offsets": [
[
35,
45
]
],
"normalized": []
},
{
"id": "split_0_train_8409_entity",
"type": "progene_text",
"text": [
"IL10R"
],
"offsets": [
[
72,
77
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5373
|
split_0_train_5373
|
[
{
"id": "split_0_train_5373_passage",
"type": "progene_text",
"text": [
"Here , we observe that IL-22R exhibits a restricted expression pattern , with highest levels of mRNA expression in pancreas and detectable expression in multiple other tissues , particularly liver , small intestine , colon , and kidney ."
],
"offsets": [
[
0,
237
]
]
}
] |
[
{
"id": "split_0_train_8410_entity",
"type": "progene_text",
"text": [
"IL-22R"
],
"offsets": [
[
23,
29
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5374
|
split_0_train_5374
|
[
{
"id": "split_0_train_5374_passage",
"type": "progene_text",
"text": [
"We find that isolated primary pancreatic acinar cells and the acinar cell line 266 - 6 respond to IL-22 with activation of Stat3 and changes in gene transcription ."
],
"offsets": [
[
0,
164
]
]
}
] |
[
{
"id": "split_0_train_8411_entity",
"type": "progene_text",
"text": [
"IL-22"
],
"offsets": [
[
98,
103
]
],
"normalized": []
},
{
"id": "split_0_train_8412_entity",
"type": "progene_text",
"text": [
"Stat3"
],
"offsets": [
[
123,
128
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5375
|
split_0_train_5375
|
[
{
"id": "split_0_train_5375_passage",
"type": "progene_text",
"text": [
"IL-22 mediates robust induction of mRNA for pancreatitis - associated protein ( PAP1 ) / Reg2 and osteopontin ( OPN ) ."
],
"offsets": [
[
0,
119
]
]
}
] |
[
{
"id": "split_0_train_8413_entity",
"type": "progene_text",
"text": [
"IL-22"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "split_0_train_8414_entity",
"type": "progene_text",
"text": [
"pancreatitis - associated protein"
],
"offsets": [
[
44,
77
]
],
"normalized": []
},
{
"id": "split_0_train_8415_entity",
"type": "progene_text",
"text": [
"PAP1"
],
"offsets": [
[
80,
84
]
],
"normalized": []
},
{
"id": "split_0_train_8416_entity",
"type": "progene_text",
"text": [
"Reg2"
],
"offsets": [
[
89,
93
]
],
"normalized": []
},
{
"id": "split_0_train_8417_entity",
"type": "progene_text",
"text": [
"osteopontin"
],
"offsets": [
[
98,
109
]
],
"normalized": []
},
{
"id": "split_0_train_8418_entity",
"type": "progene_text",
"text": [
"OPN"
],
"offsets": [
[
112,
115
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5376
|
split_0_train_5376
|
[
{
"id": "split_0_train_5376_passage",
"type": "progene_text",
"text": [
"PAP1 is a secreted protein related to the Reg family of trophic factors and was initially characterized as a protein elevated in pancreatitis ."
],
"offsets": [
[
0,
143
]
]
}
] |
[
{
"id": "split_0_train_8419_entity",
"type": "progene_text",
"text": [
"PAP1"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_8420_entity",
"type": "progene_text",
"text": [
"Reg family"
],
"offsets": [
[
42,
52
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5377
|
split_0_train_5377
|
[
{
"id": "split_0_train_5377_passage",
"type": "progene_text",
"text": [
"In vivo injection of IL-22 resulted in rapid induction of PAP1 in pancreas , a response not observed in mice deficient in IL-10Rbeta ."
],
"offsets": [
[
0,
134
]
]
}
] |
[
{
"id": "split_0_train_8421_entity",
"type": "progene_text",
"text": [
"IL-22"
],
"offsets": [
[
21,
26
]
],
"normalized": []
},
{
"id": "split_0_train_8422_entity",
"type": "progene_text",
"text": [
"PAP1"
],
"offsets": [
[
58,
62
]
],
"normalized": []
},
{
"id": "split_0_train_8423_entity",
"type": "progene_text",
"text": [
"IL-10Rbeta"
],
"offsets": [
[
122,
132
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5378
|
split_0_train_5378
|
[
{
"id": "split_0_train_5378_passage",
"type": "progene_text",
"text": [
"These results support the conclusion that IL-10Rbeta is a required common component of both the IL-10 and IL-22 receptors and suggest that IL-22 may play a role in the immune response in pancreas ."
],
"offsets": [
[
0,
197
]
]
}
] |
[
{
"id": "split_0_train_8424_entity",
"type": "progene_text",
"text": [
"IL-10Rbeta"
],
"offsets": [
[
42,
52
]
],
"normalized": []
},
{
"id": "split_0_train_8425_entity",
"type": "progene_text",
"text": [
"IL-10 and IL-22 receptors"
],
"offsets": [
[
96,
121
]
],
"normalized": []
},
{
"id": "split_0_train_8426_entity",
"type": "progene_text",
"text": [
"IL-22"
],
"offsets": [
[
139,
144
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5379
|
split_0_train_5379
|
[
{
"id": "split_0_train_5379_passage",
"type": "progene_text",
"text": [
"Relationships between diffusion tensor and q - space MRI ."
],
"offsets": [
[
0,
58
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5380
|
split_0_train_5380
|
[
{
"id": "split_0_train_5380_passage",
"type": "progene_text",
"text": [
"Fundamental relationships between diffusion tensor ( DT ) and 3D q - space MRI are derived which establish conditions when these two complementary MR methods are equivalent ."
],
"offsets": [
[
0,
174
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5381
|
split_0_train_5381
|
[
{
"id": "split_0_train_5381_passage",
"type": "progene_text",
"text": [
"It is shown that the displacement distribution measured by q - space MRI in both the large displacement ( i.e. , large r ) and the long - wavelength ( i.e. , small q ) limits is the same 3D Gaussian displacement distribution assumed in DT-MRI ."
],
"offsets": [
[
0,
244
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5382
|
split_0_train_5382
|
[
{
"id": "split_0_train_5382_passage",
"type": "progene_text",
"text": [
"In these limiting cases , q - space MR yields a dispersion tensor that is identical to the effective DT , D , measured in DT-MRI ."
],
"offsets": [
[
0,
130
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5383
|
split_0_train_5383
|
[
{
"id": "split_0_train_5383_passage",
"type": "progene_text",
"text": [
"An experiment is then proposed to measure D using q - space methods ."
],
"offsets": [
[
0,
69
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5384
|
split_0_train_5384
|
[
{
"id": "split_0_train_5384_passage",
"type": "progene_text",
"text": [
"These findings establish that the effective DT , measured in DT-MRI , characterizes molecule motions on a coarse length - scale ."
],
"offsets": [
[
0,
129
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5385
|
split_0_train_5385
|
[
{
"id": "split_0_train_5385_passage",
"type": "progene_text",
"text": [
"Finally , the feasibility of and requirements for performing 3D q - space MRI on a clinical scanner are considered ."
],
"offsets": [
[
0,
116
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5386
|
split_0_train_5386
|
[
{
"id": "split_0_train_5386_passage",
"type": "progene_text",
"text": [
"A word processor optimized for preparing journal articles and student papers ."
],
"offsets": [
[
0,
78
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5387
|
split_0_train_5387
|
[
{
"id": "split_0_train_5387_passage",
"type": "progene_text",
"text": [
"A new Windows - based word processor for preparing journal articles and student papers is described ."
],
"offsets": [
[
0,
101
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5388
|
split_0_train_5388
|
[
{
"id": "split_0_train_5388_passage",
"type": "progene_text",
"text": [
"In addition to standard features found in word processors , the present word processor provides specific help in preparing manuscripts ."
],
"offsets": [
[
0,
136
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5389
|
split_0_train_5389
|
[
{
"id": "split_0_train_5389_passage",
"type": "progene_text",
"text": [
"Clicking on \" Reference Help ( APA Form ) \" in the \" File \" menu provides a detailed help system for entering the references in a journal article ."
],
"offsets": [
[
0,
147
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5390
|
split_0_train_5390
|
[
{
"id": "split_0_train_5390_passage",
"type": "progene_text",
"text": [
"Clicking on \" Examples and Explanations of APA Form \" provides a help system with examples of the various sections of a review article , journal article that has one experiment , or journal article that has two or more experiments ."
],
"offsets": [
[
0,
232
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5391
|
split_0_train_5391
|
[
{
"id": "split_0_train_5391_passage",
"type": "progene_text",
"text": [
"The word processor can automatically place the manuscript page header and page number at the top of each page using the form required by APA and Psychonomic Society journals ."
],
"offsets": [
[
0,
175
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5392
|
split_0_train_5392
|
[
{
"id": "split_0_train_5392_passage",
"type": "progene_text",
"text": [
"The \" APA Form \" submenu of the \" Help \" menu provides detailed information about how the word processor is optimized for preparing articles and papers ."
],
"offsets": [
[
0,
153
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5393
|
split_0_train_5393
|
[
{
"id": "split_0_train_5393_passage",
"type": "progene_text",
"text": [
"Smallest real difference , a link between reproducibility and responsiveness ."
],
"offsets": [
[
0,
78
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5394
|
split_0_train_5394
|
[
{
"id": "split_0_train_5394_passage",
"type": "progene_text",
"text": [
"The aim of this study is to show the relationship between test - retest reproducibility and responsiveness and to introduce the smallest real difference ( SRD ) approach , using the sickness impact profile ( SIP ) in chronic stroke patients as an example ."
],
"offsets": [
[
0,
256
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5395
|
split_0_train_5395
|
[
{
"id": "split_0_train_5395_passage",
"type": "progene_text",
"text": [
"Forty chronic stroke patients were interviewed twice by the same examiner , with a 1 - week interval ."
],
"offsets": [
[
0,
102
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5396
|
split_0_train_5396
|
[
{
"id": "split_0_train_5396_passage",
"type": "progene_text",
"text": [
"All patients were interviewed during the qualification period preceding a randomized clinical trial ."
],
"offsets": [
[
0,
101
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5397
|
split_0_train_5397
|
[
{
"id": "split_0_train_5397_passage",
"type": "progene_text",
"text": [
"Test - retest reproducibility has been quantified by the intraclass correlation coefficient ( ICC ) ."
],
"offsets": [
[
0,
101
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5398
|
split_0_train_5398
|
[
{
"id": "split_0_train_5398_passage",
"type": "progene_text",
"text": [
"the standard error of measurement ( SEM ) and the related smallest real difference ( SRD ) ."
],
"offsets": [
[
0,
92
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5399
|
split_0_train_5399
|
[
{
"id": "split_0_train_5399_passage",
"type": "progene_text",
"text": [
"Responsiveness was defined as the ratio of the clinically relevant change to the SD of the within - stable - subject test - retest differences ."
],
"offsets": [
[
0,
144
]
]
}
] |
[] |
[] |
[] |
[] |
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