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split_0_train_5400
|
split_0_train_5400
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"The ICC for the total SIP was 0.92 , whereas the ICCs for the specified SIP categories varied from 0.63 for the category ' recreation and pastime ' to 0.88 for the category 'work' ."
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0,
181
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[] |
[] |
[] |
[] |
split_0_train_5401
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split_0_train_5401
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"However , both the SEM and the SRD far more capture the essence of the reproducibility of a measurement instrument ."
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0,
116
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}
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[] |
[] |
[] |
[] |
split_0_train_5402
|
split_0_train_5402
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"For instance , a total SIP score of an individual patient of 28.3 % ( which is taken as an example , being the mean score in the study population ) should decrease by at least 9.26 % or approximately 13 items , before any improvement beyond reproducibility noise can be detected ."
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0,
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[] |
[] |
[] |
[] |
split_0_train_5403
|
split_0_train_5403
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"The responsiveness to change of a health status measurement instrument is closely related to its test - retest reproducibility ."
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0,
128
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}
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[] |
[] |
[] |
[] |
split_0_train_5404
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split_0_train_5404
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"This relationship becomes more evident when the SEM and the SRD are used to quantify reproducibility , than when ICC or other correlation coefficients are used ."
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0,
161
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[] |
[] |
[] |
[] |
split_0_train_5405
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split_0_train_5405
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"text": [
"Consequences of CK2 signaling to the nuclear matrix ."
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0,
53
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"text": [
"CK2"
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16,
19
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[] |
[] |
[] |
split_0_train_5406
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split_0_train_5406
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"text": [
"Protein kinase CK2 is recognized as one of the key cellular signals for cell growth and proliferation ."
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0,
103
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"Protein kinase"
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"CK2"
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15,
18
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[] |
[] |
[] |
split_0_train_5407
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split_0_train_5407
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"text": [
"Its nuclear targeting appears to be critical to its role in these functions ."
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0,
77
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[] |
[] |
[] |
[] |
split_0_train_5408
|
split_0_train_5408
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"text": [
"In the nucleus , nuclear matrix ( NM ) which plays a major role in growth - related activities is a primary locus for CK2 signaling ."
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0,
133
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"CK2"
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118,
121
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[] |
[] |
[] |
split_0_train_5409
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split_0_train_5409
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"A variety of growth stimuli evoke a rapid translocation of the CK2 to the NM whereas removal of these factors has the opposite effect ."
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0,
135
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"text": [
"CK2"
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63,
66
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[] |
[] |
[] |
split_0_train_5410
|
split_0_train_5410
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[
{
"id": "split_0_train_5410_passage",
"type": "progene_text",
"text": [
"These studies , employing various experimental models of cell growth ( involving different growth - stimulatory factors ) , have suggested that rapid shuttling of CK2 to the NM is a key feature of early growth control ."
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0,
219
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"text": [
"CK2"
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"offsets": [
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163,
166
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] |
[] |
[] |
[] |
split_0_train_5411
|
split_0_train_5411
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[
{
"id": "split_0_train_5411_passage",
"type": "progene_text",
"text": [
"By contrast , removal of growth - stimulatory factors leading to the loss of cell viability is associated with early loss of CK2 from the NM ( and chromatin ) ."
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"offsets": [
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0,
160
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"text": [
"CK2"
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"offsets": [
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125,
128
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"normalized": []
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] |
[] |
[] |
[] |
split_0_train_5412
|
split_0_train_5412
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{
"id": "split_0_train_5412_passage",
"type": "progene_text",
"text": [
"This indicates that absence of CK2 from the nuclear compartment is contributory to induction of cell death via apoptosis , implying a protective role for CK2 against cell death ."
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"offsets": [
[
0,
178
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]
}
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{
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"CK2"
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31,
34
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"type": "progene_text",
"text": [
"CK2"
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"offsets": [
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154,
157
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"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5413
|
split_0_train_5413
|
[
{
"id": "split_0_train_5413_passage",
"type": "progene_text",
"text": [
"Here , we review the evidence that suggests that CK2 signaling in the NM is not only involved in cell growth but also in cell survival ."
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"offsets": [
[
0,
136
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}
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{
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"text": [
"CK2"
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"offsets": [
[
49,
52
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"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5414
|
split_0_train_5414
|
[
{
"id": "split_0_train_5414_passage",
"type": "progene_text",
"text": [
"[ Acute mesenteric vein thrombosis : diagnosis and management ]"
],
"offsets": [
[
0,
63
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5415
|
split_0_train_5415
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[
{
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"type": "progene_text",
"text": [
"OBJECTIVE :"
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"offsets": [
[
0,
11
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5416
|
split_0_train_5416
|
[
{
"id": "split_0_train_5416_passage",
"type": "progene_text",
"text": [
"To evaluate the progress in diagnosis and management of acute mesenteric vein thrombosis ( AMVT ) ."
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"offsets": [
[
0,
99
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5417
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split_0_train_5417
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"type": "progene_text",
"text": [
"METHODS :"
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"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5418
|
split_0_train_5418
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[
{
"id": "split_0_train_5418_passage",
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"text": [
"Fifteen patients with AMVT treated from January 1983 to November 1998 were reviewed retrospectively ."
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"offsets": [
[
0,
101
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5419
|
split_0_train_5419
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{
"id": "split_0_train_5419_passage",
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"text": [
"They were 7 men and 8 women , aged on average 42 years ."
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"offsets": [
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0,
56
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5420
|
split_0_train_5420
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{
"id": "split_0_train_5420_passage",
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"text": [
"The duration from onset of symptoms to admission was 24 - 168 hours ( mean 84 hours ) ."
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"offsets": [
[
0,
87
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5421
|
split_0_train_5421
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"type": "progene_text",
"text": [
"RESULTS :"
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"offsets": [
[
0,
9
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5422
|
split_0_train_5422
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[
{
"id": "split_0_train_5422_passage",
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"Six patients were diagnosed before operation , while 9 during laparotomy.Two patients received conservative treatment and the rest underwent surgery ."
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"offsets": [
[
0,
150
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5423
|
split_0_train_5423
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[
{
"id": "split_0_train_5423_passage",
"type": "progene_text",
"text": [
"The average length of bowel resection was 300 cm ."
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"offsets": [
[
0,
50
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5424
|
split_0_train_5424
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[
{
"id": "split_0_train_5424_passage",
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"text": [
"All the patients received anticoagulation therapy with heparin immediately after operation ."
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"offsets": [
[
0,
92
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}
] |
[] |
[] |
[] |
[] |
split_0_train_5425
|
split_0_train_5425
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"text": [
"Local thrombolytic therapy was given to 4 patients ."
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"offsets": [
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0,
52
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5426
|
split_0_train_5426
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"text": [
"Four patients died in hospital and two had sequelae of short bowel syndrome ."
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"offsets": [
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0,
77
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}
] |
[] |
[] |
[] |
[] |
split_0_train_5427
|
split_0_train_5427
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"text": [
"CONCLUSIONS :"
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0,
13
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}
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[] |
[] |
[] |
[] |
split_0_train_5428
|
split_0_train_5428
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"text": [
"AMVT is rare but a potentially lethal emergency disease ."
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"offsets": [
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0,
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[] |
[] |
[] |
split_0_train_5429
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split_0_train_5429
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"text": [
"Early diagnosis , anticoagulation and appropriate surgical approach are essential to improve the prognosis ."
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0,
108
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}
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[] |
[] |
[] |
[] |
split_0_train_5430
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split_0_train_5430
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{
"id": "split_0_train_5430_passage",
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"text": [
"It is important to keep vigilance for AMVT in the patients in the hypercoagulation status , especially when the symptoms are inconsistent with abdominal signs ."
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"offsets": [
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0,
160
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}
] |
[] |
[] |
[] |
[] |
split_0_train_5431
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split_0_train_5431
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{
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"text": [
"Color-US and CT appear to be sensitive in the diagnosis of this condition ."
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0,
75
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}
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[] |
[] |
[] |
[] |
split_0_train_5432
|
split_0_train_5432
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"text": [
"Local thrombolytic therapy will be effective ."
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"offsets": [
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0,
46
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5433
|
split_0_train_5433
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"text": [
"Second - look is a necessarily procedure for reserving the bowel that may be alive ."
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0,
84
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}
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[] |
[] |
[] |
[] |
split_0_train_5434
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split_0_train_5434
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"Laparoscopy technique will play an important role in the diagnosis and treatment for AMVT ."
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0,
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}
] |
[] |
[] |
[] |
[] |
split_0_train_5435
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split_0_train_5435
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{
"id": "split_0_train_5435_passage",
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"RFX-B , a MHC class II transcription factor , suppressed in human colorectal adenocarcinomas ."
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0,
94
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"transcription factor"
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23,
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[] |
[] |
[] |
split_0_train_5436
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split_0_train_5436
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"Regulatory factor X ( RFX ) is an essential MHC class II transcription factor and contains three distinct subunits of which RFX-B is one ."
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0,
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"RFX-B"
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124,
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[] |
[] |
split_0_train_5437
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split_0_train_5437
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"text": [
"Aberrant expression of MHC class II genes is associated with autoimmunity , tumour growth and failure to mount an immune response ."
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0,
131
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23,
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[] |
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split_0_train_5438
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split_0_train_5438
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"id": "split_0_train_5438_passage",
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split_0_train_5439
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split_0_train_5439
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split_0_train_5440
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split_0_train_5440
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"text": [
"Immunohistochemistry revealed that the RFX-B protein levels in macrophages were generally lower in colorectal cancerous tissue compared to adjacent non - cancerous tissue and that focally and not frequently tumour and normal epithelial cells were stained weakly for RFX-B ."
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"RFX-B"
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266,
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[] |
split_0_train_5441
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split_0_train_5441
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"id": "split_0_train_5441_passage",
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"As the expression of MHC class II correlates with the intensity of the immune response system these results may support the idea that cancer is associated with immunodeficiency and that low levels of RFX-B in interstitial macrophages could partly explain this thesis ."
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200,
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[] |
[] |
split_0_train_5442
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split_0_train_5442
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"id": "split_0_train_5442_passage",
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"acid - sensitive channels"
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60,
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}
] |
[] |
[] |
[] |
split_0_train_5443
|
split_0_train_5443
|
[
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"id": "split_0_train_5443_passage",
"type": "progene_text",
"text": [
"Acid - sensitive ion channels ( ASIC ) are proton - gated ion channels expressed in neurons of the mammalian central and peripheral nervous systems ."
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0,
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]
}
] |
[
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{
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"type": "progene_text",
"text": [
"ion channels"
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[
58,
70
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"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5444
|
split_0_train_5444
|
[
{
"id": "split_0_train_5444_passage",
"type": "progene_text",
"text": [
"The functional role of these channels is still uncertain , but they have been proposed to constitute mechanoreceptors and/or nociceptors ."
],
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0,
138
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]
}
] |
[
{
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{
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"text": [
"nociceptors"
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[
125,
136
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5445
|
split_0_train_5445
|
[
{
"id": "split_0_train_5445_passage",
"type": "progene_text",
"text": [
"We have raised specific antibodies for ASIC1 , ASIC2 , ASIC3 , and ASIC4 to examine the distribution of these proteins in neurons from dorsal root ganglia ( DRG ) and to determine their subcellular localization ."
],
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[
0,
212
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]
}
] |
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{
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{
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{
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"text": [
"ASIC4"
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"offsets": [
[
67,
72
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5446
|
split_0_train_5446
|
[
{
"id": "split_0_train_5446_passage",
"type": "progene_text",
"text": [
"Western blot analysis demonstrates that all four ASIC proteins are expressed in DRG and sciatic nerve ."
],
"offsets": [
[
0,
103
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]
}
] |
[
{
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"type": "progene_text",
"text": [
"ASIC"
],
"offsets": [
[
49,
53
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5447
|
split_0_train_5447
|
[
{
"id": "split_0_train_5447_passage",
"type": "progene_text",
"text": [
"Immunohistochemical experiments and functional measurements of unitary currents from the ASICs with the patch - clamp technique indicate that ASIC1 localizes to the plasma membrane of small - , medium - , and large - diameter cells , whereas ASIC2 and ASIC3 are preferentially in medium to large cells ."
],
"offsets": [
[
0,
303
]
]
}
] |
[
{
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"text": [
"ASIC3"
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"offsets": [
[
252,
257
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5448
|
split_0_train_5448
|
[
{
"id": "split_0_train_5448_passage",
"type": "progene_text",
"text": [
"Neurons coexpressing ASIC2 and ASIC3 form predominantly heteromeric ASIC2-3 channels ."
],
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[
0,
86
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]
}
] |
[
{
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21,
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{
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36
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{
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"text": [
"ASIC2-3 channels"
],
"offsets": [
[
68,
84
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5449
|
split_0_train_5449
|
[
{
"id": "split_0_train_5449_passage",
"type": "progene_text",
"text": [
"Two spliced forms , ASIC2a and ASIC2b , colocalize in the same population of DRG neurons ."
],
"offsets": [
[
0,
90
]
]
}
] |
[
{
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"type": "progene_text",
"text": [
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20,
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{
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"type": "progene_text",
"text": [
"ASIC2b"
],
"offsets": [
[
31,
37
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5450
|
split_0_train_5450
|
[
{
"id": "split_0_train_5450_passage",
"type": "progene_text",
"text": [
"Within cells , the ASICs are present mainly on the plasma membrane of the soma and cellular processes ."
],
"offsets": [
[
0,
103
]
]
}
] |
[
{
"id": "split_0_train_8472_entity",
"type": "progene_text",
"text": [
"ASICs"
],
"offsets": [
[
19,
24
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5451
|
split_0_train_5451
|
[
{
"id": "split_0_train_5451_passage",
"type": "progene_text",
"text": [
"Functional studies indicate that the pH sensitivity for inactivation of ASIC1 is much higher than the one for activation ; hence , increases in proton concentration will inactivate the channel ."
],
"offsets": [
[
0,
194
]
]
}
] |
[
{
"id": "split_0_train_8473_entity",
"type": "progene_text",
"text": [
"ASIC1"
],
"offsets": [
[
72,
77
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5452
|
split_0_train_5452
|
[
{
"id": "split_0_train_5452_passage",
"type": "progene_text",
"text": [
"These functional properties and localization in DRG have profound implications for the putative functional roles of ASICs in the nervous system ."
],
"offsets": [
[
0,
145
]
]
}
] |
[
{
"id": "split_0_train_8474_entity",
"type": "progene_text",
"text": [
"ASICs"
],
"offsets": [
[
116,
121
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5453
|
split_0_train_5453
|
[
{
"id": "split_0_train_5453_passage",
"type": "progene_text",
"text": [
"Structure and function of IRF-7 ."
],
"offsets": [
[
0,
33
]
]
}
] |
[
{
"id": "split_0_train_8475_entity",
"type": "progene_text",
"text": [
"IRF-7"
],
"offsets": [
[
26,
31
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5454
|
split_0_train_5454
|
[
{
"id": "split_0_train_5454_passage",
"type": "progene_text",
"text": [
"Interferon ( IFN ) regulatory factors ( IRF ) are a family of transcription factors with multiple functions ."
],
"offsets": [
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0,
109
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]
}
] |
[
{
"id": "split_0_train_8476_entity",
"type": "progene_text",
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{
"id": "split_0_train_8477_entity",
"type": "progene_text",
"text": [
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40,
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{
"id": "split_0_train_8478_entity",
"type": "progene_text",
"text": [
"transcription factors"
],
"offsets": [
[
62,
83
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5455
|
split_0_train_5455
|
[
{
"id": "split_0_train_5455_passage",
"type": "progene_text",
"text": [
"IRF-7 was initially cloned within the biologic context of Epstein - Barr virus ( EBV ) latency and discovered to have an intimate relation with the EBV primary oncogenic protein , latent membrane protein-1 ( LMP-1 ) ."
],
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[
0,
217
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]
}
] |
[
{
"id": "split_0_train_8479_entity",
"type": "progene_text",
"text": [
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0,
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{
"id": "split_0_train_8480_entity",
"type": "progene_text",
"text": [
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{
"id": "split_0_train_8481_entity",
"type": "progene_text",
"text": [
"LMP-1"
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"offsets": [
[
208,
213
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5456
|
split_0_train_5456
|
[
{
"id": "split_0_train_5456_passage",
"type": "progene_text",
"text": [
"EBV regulates and uses IRF-7 as a secondary mediator for several target genes involved in latency and immune regulation ."
],
"offsets": [
[
0,
121
]
]
}
] |
[
{
"id": "split_0_train_8482_entity",
"type": "progene_text",
"text": [
"IRF-7"
],
"offsets": [
[
23,
28
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5457
|
split_0_train_5457
|
[
{
"id": "split_0_train_5457_passage",
"type": "progene_text",
"text": [
"Other than its functions in EBV latency , IRF-7 has been identified as one of the major players in virally induced IFN production that is central to innate immunity ."
],
"offsets": [
[
0,
166
]
]
}
] |
[
{
"id": "split_0_train_8483_entity",
"type": "progene_text",
"text": [
"IRF-7"
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42,
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{
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"type": "progene_text",
"text": [
"IFN"
],
"offsets": [
[
115,
118
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5458
|
split_0_train_5458
|
[
{
"id": "split_0_train_5458_passage",
"type": "progene_text",
"text": [
"Thus , IRF-7 plays important roles in a variety of biologic systems ."
],
"offsets": [
[
0,
69
]
]
}
] |
[
{
"id": "split_0_train_8485_entity",
"type": "progene_text",
"text": [
"IRF-7"
],
"offsets": [
[
7,
12
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5459
|
split_0_train_5459
|
[
{
"id": "split_0_train_5459_passage",
"type": "progene_text",
"text": [
"The PGC-1 - related protein PERC is a selective coactivator of estrogen receptor alpha ."
],
"offsets": [
[
0,
88
]
]
}
] |
[
{
"id": "split_0_train_8486_entity",
"type": "progene_text",
"text": [
"PGC-1"
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[
4,
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},
{
"id": "split_0_train_8487_entity",
"type": "progene_text",
"text": [
"PERC"
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[
28,
32
]
],
"normalized": []
},
{
"id": "split_0_train_8488_entity",
"type": "progene_text",
"text": [
"coactivator of estrogen receptor alpha"
],
"offsets": [
[
48,
86
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5460
|
split_0_train_5460
|
[
{
"id": "split_0_train_5460_passage",
"type": "progene_text",
"text": [
"Peroxisome proliferator - activated receptor gamma coactivator-1 ( PGC-1 ) is a tissue - specific coactivator that enhances the activity of many nuclear receptors and coordinates transcriptional programs important for energy metabolism ."
],
"offsets": [
[
0,
237
]
]
}
] |
[
{
"id": "split_0_train_8489_entity",
"type": "progene_text",
"text": [
"Peroxisome proliferator - activated receptor gamma coactivator-1"
],
"offsets": [
[
0,
64
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],
"normalized": []
},
{
"id": "split_0_train_8490_entity",
"type": "progene_text",
"text": [
"PGC-1"
],
"offsets": [
[
67,
72
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5461
|
split_0_train_5461
|
[
{
"id": "split_0_train_5461_passage",
"type": "progene_text",
"text": [
"We describe here a novel PGC-1 - related coactivator that is expressed in a similar tissue - specific manner as PGC-1 , with the highest levels in heart and skeletal muscle ."
],
"offsets": [
[
0,
174
]
]
}
] |
[
{
"id": "split_0_train_8491_entity",
"type": "progene_text",
"text": [
"PGC-1"
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[
25,
30
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],
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},
{
"id": "split_0_train_8492_entity",
"type": "progene_text",
"text": [
"PGC-1"
],
"offsets": [
[
112,
117
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5462
|
split_0_train_5462
|
[
{
"id": "split_0_train_5462_passage",
"type": "progene_text",
"text": [
"In contrast to PGC-1 , the new coactivator shows high receptor specificity ."
],
"offsets": [
[
0,
76
]
]
}
] |
[
{
"id": "split_0_train_8493_entity",
"type": "progene_text",
"text": [
"PGC-1"
],
"offsets": [
[
15,
20
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5463
|
split_0_train_5463
|
[
{
"id": "split_0_train_5463_passage",
"type": "progene_text",
"text": [
"It enhances potently the activity of estrogen receptor ( ER ) alpha , while having only small effects on other receptors ."
],
"offsets": [
[
0,
122
]
]
}
] |
[
{
"id": "split_0_train_8494_entity",
"type": "progene_text",
"text": [
"estrogen receptor ( ER ) alpha"
],
"offsets": [
[
37,
67
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5464
|
split_0_train_5464
|
[
{
"id": "split_0_train_5464_passage",
"type": "progene_text",
"text": [
"Because of its nuclear receptor selectivity , we have termed the new protein PERC ( PGC-1 related Estrogen Receptor Coactivator ) ."
],
"offsets": [
[
0,
131
]
]
}
] |
[
{
"id": "split_0_train_8495_entity",
"type": "progene_text",
"text": [
"PERC"
],
"offsets": [
[
77,
81
]
],
"normalized": []
},
{
"id": "split_0_train_8496_entity",
"type": "progene_text",
"text": [
"PGC-1 related Estrogen Receptor Coactivator"
],
"offsets": [
[
84,
127
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5465
|
split_0_train_5465
|
[
{
"id": "split_0_train_5465_passage",
"type": "progene_text",
"text": [
"We show here that the coactivation function of PERC relies on a bipartite transcriptional activation domain and two LXXLL motifs that interact with the AF2 domain of ERalpha in an estrogen - dependent manner ."
],
"offsets": [
[
0,
209
]
]
}
] |
[
{
"id": "split_0_train_8497_entity",
"type": "progene_text",
"text": [
"PERC"
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"offsets": [
[
47,
51
]
],
"normalized": []
},
{
"id": "split_0_train_8498_entity",
"type": "progene_text",
"text": [
"ERalpha"
],
"offsets": [
[
166,
173
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5466
|
split_0_train_5466
|
[
{
"id": "split_0_train_5466_passage",
"type": "progene_text",
"text": [
"PERC and PGC-1 are likely to have different functions in ER signaling ."
],
"offsets": [
[
0,
71
]
]
}
] |
[
{
"id": "split_0_train_8499_entity",
"type": "progene_text",
"text": [
"PERC"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_8500_entity",
"type": "progene_text",
"text": [
"PGC-1"
],
"offsets": [
[
9,
14
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],
"normalized": []
},
{
"id": "split_0_train_8501_entity",
"type": "progene_text",
"text": [
"ER"
],
"offsets": [
[
57,
59
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5467
|
split_0_train_5467
|
[
{
"id": "split_0_train_5467_passage",
"type": "progene_text",
"text": [
"Whereas PERC acts selectively on ERalpha and not on the second estrogen receptor ERbeta , PGC-1 coactivates strongly both ERs ."
],
"offsets": [
[
0,
127
]
]
}
] |
[
{
"id": "split_0_train_8502_entity",
"type": "progene_text",
"text": [
"PERC"
],
"offsets": [
[
8,
12
]
],
"normalized": []
},
{
"id": "split_0_train_8503_entity",
"type": "progene_text",
"text": [
"ERalpha"
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"offsets": [
[
33,
40
]
],
"normalized": []
},
{
"id": "split_0_train_8504_entity",
"type": "progene_text",
"text": [
"estrogen receptor ERbeta"
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"offsets": [
[
63,
87
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],
"normalized": []
},
{
"id": "split_0_train_8505_entity",
"type": "progene_text",
"text": [
"PGC-1"
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"offsets": [
[
90,
95
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],
"normalized": []
},
{
"id": "split_0_train_8506_entity",
"type": "progene_text",
"text": [
"ERs"
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"offsets": [
[
122,
125
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5468
|
split_0_train_5468
|
[
{
"id": "split_0_train_5468_passage",
"type": "progene_text",
"text": [
"Moreover , PERC and PGC-1 show distinct preferences for enhancing ERalpha in different promoter contexts ."
],
"offsets": [
[
0,
106
]
]
}
] |
[
{
"id": "split_0_train_8507_entity",
"type": "progene_text",
"text": [
"PERC"
],
"offsets": [
[
11,
15
]
],
"normalized": []
},
{
"id": "split_0_train_8508_entity",
"type": "progene_text",
"text": [
"PGC-1"
],
"offsets": [
[
20,
25
]
],
"normalized": []
},
{
"id": "split_0_train_8509_entity",
"type": "progene_text",
"text": [
"ERalpha"
],
"offsets": [
[
66,
73
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5469
|
split_0_train_5469
|
[
{
"id": "split_0_train_5469_passage",
"type": "progene_text",
"text": [
"Finally , PERC enhances the ERalpha - mediated response to the partial agonist tamoxifen , while PGC-1 modestly represses it ."
],
"offsets": [
[
0,
126
]
]
}
] |
[
{
"id": "split_0_train_8510_entity",
"type": "progene_text",
"text": [
"PERC"
],
"offsets": [
[
10,
14
]
],
"normalized": []
},
{
"id": "split_0_train_8511_entity",
"type": "progene_text",
"text": [
"ERalpha"
],
"offsets": [
[
28,
35
]
],
"normalized": []
},
{
"id": "split_0_train_8512_entity",
"type": "progene_text",
"text": [
"PGC-1"
],
"offsets": [
[
97,
102
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5470
|
split_0_train_5470
|
[
{
"id": "split_0_train_5470_passage",
"type": "progene_text",
"text": [
"The two coactivators are likely to mediate distinct , tissue - specific responses to estrogens ."
],
"offsets": [
[
0,
96
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5471
|
split_0_train_5471
|
[
{
"id": "split_0_train_5471_passage",
"type": "progene_text",
"text": [
"mRNA expression of EGF receptor ligands in atrophic gastritis before and after Helicobacter pylori eradication ."
],
"offsets": [
[
0,
112
]
]
}
] |
[
{
"id": "split_0_train_8513_entity",
"type": "progene_text",
"text": [
"EGF receptor"
],
"offsets": [
[
19,
31
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5472
|
split_0_train_5472
|
[
{
"id": "split_0_train_5472_passage",
"type": "progene_text",
"text": [
"BACKGROUND :"
],
"offsets": [
[
0,
12
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5473
|
split_0_train_5473
|
[
{
"id": "split_0_train_5473_passage",
"type": "progene_text",
"text": [
"Epidermal growth factor ( EGF ) receptor ligands ( EGFRL ) including transforming growth factor alpha ( TGF-alpha ) , amphiregulin , and heparin binding - EGF ( HB-EGF ) are involved in gastric mucosal repair in chronic gastritis ."
],
"offsets": [
[
0,
231
]
]
}
] |
[
{
"id": "split_0_train_8514_entity",
"type": "progene_text",
"text": [
"Epidermal growth factor ( EGF ) receptor"
],
"offsets": [
[
0,
40
]
],
"normalized": []
},
{
"id": "split_0_train_8515_entity",
"type": "progene_text",
"text": [
"transforming growth factor alpha"
],
"offsets": [
[
69,
101
]
],
"normalized": []
},
{
"id": "split_0_train_8516_entity",
"type": "progene_text",
"text": [
"TGF-alpha"
],
"offsets": [
[
104,
113
]
],
"normalized": []
},
{
"id": "split_0_train_8517_entity",
"type": "progene_text",
"text": [
"amphiregulin"
],
"offsets": [
[
118,
130
]
],
"normalized": []
},
{
"id": "split_0_train_8518_entity",
"type": "progene_text",
"text": [
"heparin binding - EGF"
],
"offsets": [
[
137,
158
]
],
"normalized": []
},
{
"id": "split_0_train_8519_entity",
"type": "progene_text",
"text": [
"HB-EGF"
],
"offsets": [
[
161,
167
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5474
|
split_0_train_5474
|
[
{
"id": "split_0_train_5474_passage",
"type": "progene_text",
"text": [
"Their mRNA expression has been shown to be upregulated after Helicobacter pylori ( H.p. ) - eradication but little is known about this gene expression in atrophic gastritis ."
],
"offsets": [
[
0,
174
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5475
|
split_0_train_5475
|
[
{
"id": "split_0_train_5475_passage",
"type": "progene_text",
"text": [
"The purpose of our study was to investigate EGFRL mRNA expression in gastric mucosa of patients with atrophic gastritis before and after H.p. - eradication ."
],
"offsets": [
[
0,
157
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5476
|
split_0_train_5476
|
[
{
"id": "split_0_train_5476_passage",
"type": "progene_text",
"text": [
"MATERIAL / METHODS :"
],
"offsets": [
[
0,
20
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5477
|
split_0_train_5477
|
[
{
"id": "split_0_train_5477_passage",
"type": "progene_text",
"text": [
"Antral mucosal biopsies were obtained during endoscopy in 10 H.p. positive patients with atrophic gastritis and in 10 H.p. negative controls with intact mucosa ."
],
"offsets": [
[
0,
161
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5478
|
split_0_train_5478
|
[
{
"id": "split_0_train_5478_passage",
"type": "progene_text",
"text": [
"Total RNA of antral biopsies was extracted and RT - PCR was performed , the PCR - products being measured densitometrically ."
],
"offsets": [
[
0,
125
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5479
|
split_0_train_5479
|
[
{
"id": "split_0_train_5479_passage",
"type": "progene_text",
"text": [
"Values were compared with mRNA expressions in H.p. negative antral mucosa ( n = 10 ) ."
],
"offsets": [
[
0,
86
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5480
|
split_0_train_5480
|
[
{
"id": "split_0_train_5480_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5481
|
split_0_train_5481
|
[
{
"id": "split_0_train_5481_passage",
"type": "progene_text",
"text": [
"Gastric biopsies revealed mRNA expression for TGF-alpha , amphiregulin and HB-EGF , both in H.p. positive atrophic antritis and in H.p. negative healthy mucosa ."
],
"offsets": [
[
0,
161
]
]
}
] |
[
{
"id": "split_0_train_8520_entity",
"type": "progene_text",
"text": [
"TGF-alpha"
],
"offsets": [
[
46,
55
]
],
"normalized": []
},
{
"id": "split_0_train_8521_entity",
"type": "progene_text",
"text": [
"amphiregulin"
],
"offsets": [
[
58,
70
]
],
"normalized": []
},
{
"id": "split_0_train_8522_entity",
"type": "progene_text",
"text": [
"HB-EGF"
],
"offsets": [
[
75,
81
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5482
|
split_0_train_5482
|
[
{
"id": "split_0_train_5482_passage",
"type": "progene_text",
"text": [
"The mRNA expression of TGF-alpha in atrophic gastritis was significantly upregulated after H.p. - eradication , whereas that of amphiregulin did not change after this eradication ."
],
"offsets": [
[
0,
180
]
]
}
] |
[
{
"id": "split_0_train_8523_entity",
"type": "progene_text",
"text": [
"TGF-alpha"
],
"offsets": [
[
23,
32
]
],
"normalized": []
},
{
"id": "split_0_train_8524_entity",
"type": "progene_text",
"text": [
"amphiregulin"
],
"offsets": [
[
128,
140
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5483
|
split_0_train_5483
|
[
{
"id": "split_0_train_5483_passage",
"type": "progene_text",
"text": [
"Expression of HB-EGF mRNA was higher in H.p.-infection than after H.p. - eradication or in H.p. negative healthy subjects ."
],
"offsets": [
[
0,
123
]
]
}
] |
[
{
"id": "split_0_train_8525_entity",
"type": "progene_text",
"text": [
"HB-EGF"
],
"offsets": [
[
14,
20
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5484
|
split_0_train_5484
|
[
{
"id": "split_0_train_5484_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5485
|
split_0_train_5485
|
[
{
"id": "split_0_train_5485_passage",
"type": "progene_text",
"text": [
"H.p. positive atrophic gastritis is associated with differential mRNA expression of EGF receptor ligands ."
],
"offsets": [
[
0,
106
]
]
}
] |
[
{
"id": "split_0_train_8526_entity",
"type": "progene_text",
"text": [
"EGF receptor"
],
"offsets": [
[
84,
96
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5486
|
split_0_train_5486
|
[
{
"id": "split_0_train_5486_passage",
"type": "progene_text",
"text": [
"H.p.-eradication in this entity leads to unequal changes of these growth factor expressions compared to chronic active gastritis without atrophy ."
],
"offsets": [
[
0,
146
]
]
}
] |
[
{
"id": "split_0_train_8527_entity",
"type": "progene_text",
"text": [
"growth factor"
],
"offsets": [
[
66,
79
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5487
|
split_0_train_5487
|
[
{
"id": "split_0_train_5487_passage",
"type": "progene_text",
"text": [
"Distinct expression patterns of two zebrafish homologues of the human APP gene during embryonic development ."
],
"offsets": [
[
0,
109
]
]
}
] |
[
{
"id": "split_0_train_8528_entity",
"type": "progene_text",
"text": [
"APP"
],
"offsets": [
[
70,
73
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5488
|
split_0_train_5488
|
[
{
"id": "split_0_train_5488_passage",
"type": "progene_text",
"text": [
"The human amyloid protein precursor ( APP ) gene correlates with early onset of Alzheimer 's disease in humans ."
],
"offsets": [
[
0,
112
]
]
}
] |
[
{
"id": "split_0_train_8529_entity",
"type": "progene_text",
"text": [
"amyloid protein precursor"
],
"offsets": [
[
10,
35
]
],
"normalized": []
},
{
"id": "split_0_train_8530_entity",
"type": "progene_text",
"text": [
"APP"
],
"offsets": [
[
38,
41
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5489
|
split_0_train_5489
|
[
{
"id": "split_0_train_5489_passage",
"type": "progene_text",
"text": [
"We have identified two APP homologues in zebrafish , which we call appa and appb ."
],
"offsets": [
[
0,
82
]
]
}
] |
[
{
"id": "split_0_train_8531_entity",
"type": "progene_text",
"text": [
"APP"
],
"offsets": [
[
23,
26
]
],
"normalized": []
},
{
"id": "split_0_train_8532_entity",
"type": "progene_text",
"text": [
"appa"
],
"offsets": [
[
67,
71
]
],
"normalized": []
},
{
"id": "split_0_train_8533_entity",
"type": "progene_text",
"text": [
"appb"
],
"offsets": [
[
76,
80
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5490
|
split_0_train_5490
|
[
{
"id": "split_0_train_5490_passage",
"type": "progene_text",
"text": [
"They show a high degree of identity to human APP particularly in the beta APP42 and the transmembrane domain ."
],
"offsets": [
[
0,
110
]
]
}
] |
[
{
"id": "split_0_train_8534_entity",
"type": "progene_text",
"text": [
"APP"
],
"offsets": [
[
45,
48
]
],
"normalized": []
},
{
"id": "split_0_train_8535_entity",
"type": "progene_text",
"text": [
"beta APP42"
],
"offsets": [
[
69,
79
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5491
|
split_0_train_5491
|
[
{
"id": "split_0_train_5491_passage",
"type": "progene_text",
"text": [
"Widespread expression of both appa and appb was detected from mid - gastrulation until the bud stage ."
],
"offsets": [
[
0,
102
]
]
}
] |
[
{
"id": "split_0_train_8536_entity",
"type": "progene_text",
"text": [
"appa"
],
"offsets": [
[
30,
34
]
],
"normalized": []
},
{
"id": "split_0_train_8537_entity",
"type": "progene_text",
"text": [
"appb"
],
"offsets": [
[
39,
43
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5492
|
split_0_train_5492
|
[
{
"id": "split_0_train_5492_passage",
"type": "progene_text",
"text": [
"During segmentation , the two genes diverged in their pattern of expression : at 14 h post - fertilisation ( hpf ) and 18 hpf both genes were expressed rostrally in the prospective CNS , but only appa was found caudally in the paraxial segmental plate and presomitic mesoderm , excluding the midline ."
],
"offsets": [
[
0,
301
]
]
}
] |
[
{
"id": "split_0_train_8538_entity",
"type": "progene_text",
"text": [
"appa"
],
"offsets": [
[
196,
200
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5493
|
split_0_train_5493
|
[
{
"id": "split_0_train_5493_passage",
"type": "progene_text",
"text": [
"In contrast , appb was found caudally in the neural rod at 14 hpf and the developing spinal cord at 18 hpf ."
],
"offsets": [
[
0,
108
]
]
}
] |
[
{
"id": "split_0_train_8539_entity",
"type": "progene_text",
"text": [
"appb"
],
"offsets": [
[
14,
18
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5494
|
split_0_train_5494
|
[
{
"id": "split_0_train_5494_passage",
"type": "progene_text",
"text": [
"Later , at 24 hpf both genes shared common expression domains , namely the telencephalon , the ventral diencephalon , the trigeminal ganglia , and the posterior lateral line ganglia ."
],
"offsets": [
[
0,
183
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5495
|
split_0_train_5495
|
[
{
"id": "split_0_train_5495_passage",
"type": "progene_text",
"text": [
"Unique expression domains for appa were the lens , the otic vesicles and the somites , while appb was expressed in a serially repeated set of nuclei within the hindbrain , the ventral mesencephalon and the motoneurones of the developing spinal cord ."
],
"offsets": [
[
0,
250
]
]
}
] |
[
{
"id": "split_0_train_8540_entity",
"type": "progene_text",
"text": [
"appa"
],
"offsets": [
[
30,
34
]
],
"normalized": []
},
{
"id": "split_0_train_8541_entity",
"type": "progene_text",
"text": [
"appb"
],
"offsets": [
[
93,
97
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5496
|
split_0_train_5496
|
[
{
"id": "split_0_train_5496_passage",
"type": "progene_text",
"text": [
"Characterization of damage modes in dental ceramic bilayer structures ."
],
"offsets": [
[
0,
71
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5497
|
split_0_train_5497
|
[
{
"id": "split_0_train_5497_passage",
"type": "progene_text",
"text": [
"Results of contact tests using spherical indenters on flat ceramic coating layers bonded to compliant substrates are reported for selected dental ceramics ."
],
"offsets": [
[
0,
156
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5498
|
split_0_train_5498
|
[
{
"id": "split_0_train_5498_passage",
"type": "progene_text",
"text": [
"Critical loads to produce various damage modes , cone cracking , and quasiplasticity at the top surfaces and radial cracking at the lower ( inner ) surfaces are measured as a function of ceramic - layer thickness ."
],
"offsets": [
[
0,
214
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5499
|
split_0_train_5499
|
[
{
"id": "split_0_train_5499_passage",
"type": "progene_text",
"text": [
"It is proposed that these damage modes , especially radial cracking , are directly relevant to the failure of all - ceramic dental crowns ."
],
"offsets": [
[
0,
139
]
]
}
] |
[] |
[] |
[] |
[] |
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