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stringlengths 15
19
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stringlengths 15
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| passages
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|---|---|---|---|---|---|---|
split_0_train_5600
|
split_0_train_5600
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[
{
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"Human CAP1 is a key factor in the recycling of cofilin and actin for rapid actin turnover ."
],
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0,
91
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}
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"actin"
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75,
80
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] |
[] |
[] |
[] |
split_0_train_5601
|
split_0_train_5601
|
[
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"text": [
"Cofilin - ADF ( actin - depolymerizing factor ) is an essential driver of actin - based motility ."
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0,
98
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}
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{
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"text": [
"actin"
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74,
79
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}
] |
[] |
[] |
[] |
split_0_train_5602
|
split_0_train_5602
|
[
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"type": "progene_text",
"text": [
"We discovered two proteins , p65 and p55 , that are components of the actin - cofilin complex in a human HEK293 cell extract and identified p55 as CAP1 / ASP56 , a human homologue of yeast CAP / SRV2 ( cyclase - associated protein ) ."
],
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0,
234
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}
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147,
151
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{
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"text": [
"cyclase - associated protein"
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202,
230
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}
] |
[] |
[] |
[] |
split_0_train_5603
|
split_0_train_5603
|
[
{
"id": "split_0_train_5603_passage",
"type": "progene_text",
"text": [
"CAP is a bifunctional protein with an N - terminal domain that binds to Ras - responsive adenylyl cyclase and a C - terminal domain that inhibits actin polymerization ."
],
"offsets": [
[
0,
168
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]
}
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[
{
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"CAP"
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3
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{
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{
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"type": "progene_text",
"text": [
"actin"
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"offsets": [
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146,
151
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5604
|
split_0_train_5604
|
[
{
"id": "split_0_train_5604_passage",
"type": "progene_text",
"text": [
"Surprisingly , we found that the N - terminal domain of CAP1 , but not the C - terminal domain , is responsible for the interaction with the actin - cofilin complex ."
],
"offsets": [
[
0,
166
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]
}
] |
[
{
"id": "split_0_train_8603_entity",
"type": "progene_text",
"text": [
"CAP1"
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56,
60
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{
"id": "split_0_train_8604_entity",
"type": "progene_text",
"text": [
"actin"
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141,
146
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{
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"type": "progene_text",
"text": [
"cofilin"
],
"offsets": [
[
149,
156
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5605
|
split_0_train_5605
|
[
{
"id": "split_0_train_5605_passage",
"type": "progene_text",
"text": [
"The N - terminal domain of CAP1 was also found to accelerate the depolymerization of F-actin at the pointed end , which was further enhanced in the presence of cofilin and/or the C - terminal domain of CAP1 ."
],
"offsets": [
[
0,
208
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]
}
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[
{
"id": "split_0_train_8606_entity",
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27,
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{
"id": "split_0_train_8607_entity",
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"text": [
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85,
92
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{
"id": "split_0_train_8608_entity",
"type": "progene_text",
"text": [
"cofilin"
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160,
167
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{
"id": "split_0_train_8609_entity",
"type": "progene_text",
"text": [
"CAP1"
],
"offsets": [
[
202,
206
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5606
|
split_0_train_5606
|
[
{
"id": "split_0_train_5606_passage",
"type": "progene_text",
"text": [
"Moreover , CAP1 and its C - terminal domain were observed to facilitate filament elongation at the barbed end and to stimulate ADP-ATP exchange on G-actin , a process that regenerates easily polymerizable G-actin ."
],
"offsets": [
[
0,
214
]
]
}
] |
[
{
"id": "split_0_train_8610_entity",
"type": "progene_text",
"text": [
"CAP1"
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"offsets": [
[
11,
15
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{
"id": "split_0_train_8611_entity",
"type": "progene_text",
"text": [
"G-actin"
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147,
154
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{
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"type": "progene_text",
"text": [
"G-actin"
],
"offsets": [
[
205,
212
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5607
|
split_0_train_5607
|
[
{
"id": "split_0_train_5607_passage",
"type": "progene_text",
"text": [
"Although cofilin inhibited the nucleotide exchange on G-actin even in the presence of the C - terminal domain of CAP1 , its N - terminal domain relieved this inhibition ."
],
"offsets": [
[
0,
170
]
]
}
] |
[
{
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"text": [
"cofilin"
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[
9,
16
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{
"id": "split_0_train_8614_entity",
"type": "progene_text",
"text": [
"G-actin"
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54,
61
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},
{
"id": "split_0_train_8615_entity",
"type": "progene_text",
"text": [
"CAP1"
],
"offsets": [
[
113,
117
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5608
|
split_0_train_5608
|
[
{
"id": "split_0_train_5608_passage",
"type": "progene_text",
"text": [
"Thus , CAP1 plays a key role in speeding up the turnover of actin filaments by effectively recycling cofilin and actin and through its effect on both ends of actin filament ."
],
"offsets": [
[
0,
174
]
]
}
] |
[
{
"id": "split_0_train_8616_entity",
"type": "progene_text",
"text": [
"CAP1"
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"offsets": [
[
7,
11
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],
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{
"id": "split_0_train_8617_entity",
"type": "progene_text",
"text": [
"actin"
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"offsets": [
[
60,
65
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],
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{
"id": "split_0_train_8618_entity",
"type": "progene_text",
"text": [
"cofilin"
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"offsets": [
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101,
108
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],
"normalized": []
},
{
"id": "split_0_train_8619_entity",
"type": "progene_text",
"text": [
"actin"
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"offsets": [
[
113,
118
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],
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{
"id": "split_0_train_8620_entity",
"type": "progene_text",
"text": [
"actin"
],
"offsets": [
[
158,
163
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5609
|
split_0_train_5609
|
[
{
"id": "split_0_train_5609_passage",
"type": "progene_text",
"text": [
"Expression , modulation and signalling of IL-17 receptor in fibroblast - like synoviocytes of patients with rheumatoid arthritis ."
],
"offsets": [
[
0,
130
]
]
}
] |
[
{
"id": "split_0_train_8621_entity",
"type": "progene_text",
"text": [
"IL-17 receptor"
],
"offsets": [
[
42,
56
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5610
|
split_0_train_5610
|
[
{
"id": "split_0_train_5610_passage",
"type": "progene_text",
"text": [
"Interleukin-17 ( IL-17 ) has been characterized as a proinflammatory cytokine produced by CD4 + CD45RO + memory T cells ."
],
"offsets": [
[
0,
121
]
]
}
] |
[
{
"id": "split_0_train_8622_entity",
"type": "progene_text",
"text": [
"Interleukin-17"
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"offsets": [
[
0,
14
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{
"id": "split_0_train_8623_entity",
"type": "progene_text",
"text": [
"IL-17"
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17,
22
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{
"id": "split_0_train_8624_entity",
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"text": [
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69,
77
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{
"id": "split_0_train_8625_entity",
"type": "progene_text",
"text": [
"CD4"
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"offsets": [
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90,
93
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{
"id": "split_0_train_8626_entity",
"type": "progene_text",
"text": [
"CD45RO"
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"offsets": [
[
96,
102
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5611
|
split_0_train_5611
|
[
{
"id": "split_0_train_5611_passage",
"type": "progene_text",
"text": [
"Overproduction of IL-17 was detected in the synovium of patients with rheumatoid arthritis ( RA ) compared to patients with osteoarthritis ."
],
"offsets": [
[
0,
140
]
]
}
] |
[
{
"id": "split_0_train_8627_entity",
"type": "progene_text",
"text": [
"IL-17"
],
"offsets": [
[
18,
23
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5612
|
split_0_train_5612
|
[
{
"id": "split_0_train_5612_passage",
"type": "progene_text",
"text": [
"In contrast to the restricted expression of IL-17 , the IL-17 receptor ( IL-17R / CDw217 ) is expressed ubiquitously ."
],
"offsets": [
[
0,
118
]
]
}
] |
[
{
"id": "split_0_train_8628_entity",
"type": "progene_text",
"text": [
"IL-17"
],
"offsets": [
[
44,
49
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],
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},
{
"id": "split_0_train_8629_entity",
"type": "progene_text",
"text": [
"IL-17 receptor"
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[
56,
70
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],
"normalized": []
},
{
"id": "split_0_train_8630_entity",
"type": "progene_text",
"text": [
"IL-17R"
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73,
79
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],
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},
{
"id": "split_0_train_8631_entity",
"type": "progene_text",
"text": [
"CDw217"
],
"offsets": [
[
82,
88
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5613
|
split_0_train_5613
|
[
{
"id": "split_0_train_5613_passage",
"type": "progene_text",
"text": [
"Using a real - time RT - PCR assay , we detected similar absolute levels of IL-17R mRNA expression in fibroblast - like synoviocytes ( SFC ) from patients with RA ( mean 9 pg / microg total RNA ; ranged from 0.1 pg to 96 pg IL-17R mRNA / microg total RNA ) compared to synoviocytes of non - RA patients ."
],
"offsets": [
[
0,
304
]
]
}
] |
[
{
"id": "split_0_train_8632_entity",
"type": "progene_text",
"text": [
"IL-17R"
],
"offsets": [
[
76,
82
]
],
"normalized": []
},
{
"id": "split_0_train_8633_entity",
"type": "progene_text",
"text": [
"IL-17R"
],
"offsets": [
[
224,
230
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5614
|
split_0_train_5614
|
[
{
"id": "split_0_train_5614_passage",
"type": "progene_text",
"text": [
"Analysis of the IL-17R surface expression confirmed the results obtained for IL-17R mRNA expression ."
],
"offsets": [
[
0,
101
]
]
}
] |
[
{
"id": "split_0_train_8634_entity",
"type": "progene_text",
"text": [
"IL-17R"
],
"offsets": [
[
16,
22
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],
"normalized": []
},
{
"id": "split_0_train_8635_entity",
"type": "progene_text",
"text": [
"IL-17R"
],
"offsets": [
[
77,
83
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5615
|
split_0_train_5615
|
[
{
"id": "split_0_train_5615_passage",
"type": "progene_text",
"text": [
"Exposure of SFC to IL-17 led to a mRNA induction of CXC chemokines IL-8 , GRO-alpha and GRO-beta ."
],
"offsets": [
[
0,
98
]
]
}
] |
[
{
"id": "split_0_train_8636_entity",
"type": "progene_text",
"text": [
"IL-17"
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19,
24
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{
"id": "split_0_train_8637_entity",
"type": "progene_text",
"text": [
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52,
66
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{
"id": "split_0_train_8638_entity",
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"IL-8"
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67,
71
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{
"id": "split_0_train_8639_entity",
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74,
83
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{
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"type": "progene_text",
"text": [
"GRO-beta"
],
"offsets": [
[
88,
96
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5616
|
split_0_train_5616
|
[
{
"id": "split_0_train_5616_passage",
"type": "progene_text",
"text": [
"An anti - IL-17 antibody blocked these effects of IL-17 ."
],
"offsets": [
[
0,
57
]
]
}
] |
[
{
"id": "split_0_train_8641_entity",
"type": "progene_text",
"text": [
"IL-17"
],
"offsets": [
[
10,
15
]
],
"normalized": []
},
{
"id": "split_0_train_8642_entity",
"type": "progene_text",
"text": [
"IL-17"
],
"offsets": [
[
50,
55
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5617
|
split_0_train_5617
|
[
{
"id": "split_0_train_5617_passage",
"type": "progene_text",
"text": [
"The MAPK p38 appears necessary for the regulation of IL-8 , GRO-alpha and GRO-beta expression as shown by inhibition with SB203580 ."
],
"offsets": [
[
0,
132
]
]
}
] |
[
{
"id": "split_0_train_8643_entity",
"type": "progene_text",
"text": [
"MAPK p38"
],
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[
4,
12
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],
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},
{
"id": "split_0_train_8644_entity",
"type": "progene_text",
"text": [
"IL-8"
],
"offsets": [
[
53,
57
]
],
"normalized": []
},
{
"id": "split_0_train_8645_entity",
"type": "progene_text",
"text": [
"GRO-alpha"
],
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60,
69
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],
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},
{
"id": "split_0_train_8646_entity",
"type": "progene_text",
"text": [
"GRO-beta"
],
"offsets": [
[
74,
82
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5618
|
split_0_train_5618
|
[
{
"id": "split_0_train_5618_passage",
"type": "progene_text",
"text": [
"The inhibitors genistein ( tyrosine kinase inhibitor ) and calphostin C ( inhibitor of protein kinase C ) reduced significantly the IL-17 - stimulated mRNA expression of IL-8 , GRO-alpha and GRO-beta in SFC , whereas PD98059 ( inhibitor of MEK-1/2 ) was without effect ."
],
"offsets": [
[
0,
270
]
]
}
] |
[
{
"id": "split_0_train_8647_entity",
"type": "progene_text",
"text": [
"tyrosine kinase"
],
"offsets": [
[
27,
42
]
],
"normalized": []
},
{
"id": "split_0_train_8648_entity",
"type": "progene_text",
"text": [
"protein kinase C"
],
"offsets": [
[
87,
103
]
],
"normalized": []
},
{
"id": "split_0_train_8649_entity",
"type": "progene_text",
"text": [
"IL-17"
],
"offsets": [
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132,
137
]
],
"normalized": []
},
{
"id": "split_0_train_8650_entity",
"type": "progene_text",
"text": [
"IL-8"
],
"offsets": [
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170,
174
]
],
"normalized": []
},
{
"id": "split_0_train_8651_entity",
"type": "progene_text",
"text": [
"GRO-alpha"
],
"offsets": [
[
177,
186
]
],
"normalized": []
},
{
"id": "split_0_train_8652_entity",
"type": "progene_text",
"text": [
"GRO-beta"
],
"offsets": [
[
191,
199
]
],
"normalized": []
},
{
"id": "split_0_train_8653_entity",
"type": "progene_text",
"text": [
"MEK-1/2"
],
"offsets": [
[
240,
247
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5619
|
split_0_train_5619
|
[
{
"id": "split_0_train_5619_passage",
"type": "progene_text",
"text": [
"Pharmacological drugs used in therapy of RA , such as cyclosporin and methotrexate , induced a fourfold increase of IL-17R mRNA expression and augmented the IL-17 - stimulated IL-8 expression ."
],
"offsets": [
[
0,
193
]
]
}
] |
[
{
"id": "split_0_train_8654_entity",
"type": "progene_text",
"text": [
"IL-17R"
],
"offsets": [
[
116,
122
]
],
"normalized": []
},
{
"id": "split_0_train_8655_entity",
"type": "progene_text",
"text": [
"IL-17"
],
"offsets": [
[
157,
162
]
],
"normalized": []
},
{
"id": "split_0_train_8656_entity",
"type": "progene_text",
"text": [
"IL-8"
],
"offsets": [
[
176,
180
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5620
|
split_0_train_5620
|
[
{
"id": "split_0_train_5620_passage",
"type": "progene_text",
"text": [
"Our results support the hypothesis that IL-17 / IL-17R may play a significant role in the pathogenesis of RA contributing to an unbalanced production of cytokines as well as participating in connective tissue remodelling ."
],
"offsets": [
[
0,
222
]
]
}
] |
[
{
"id": "split_0_train_8657_entity",
"type": "progene_text",
"text": [
"IL-17"
],
"offsets": [
[
40,
45
]
],
"normalized": []
},
{
"id": "split_0_train_8658_entity",
"type": "progene_text",
"text": [
"IL-17R"
],
"offsets": [
[
48,
54
]
],
"normalized": []
},
{
"id": "split_0_train_8659_entity",
"type": "progene_text",
"text": [
"cytokines"
],
"offsets": [
[
153,
162
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5621
|
split_0_train_5621
|
[
{
"id": "split_0_train_5621_passage",
"type": "progene_text",
"text": [
"Proteinase 3 and dihydrolipoamide dehydrogenase ( E3 ) are major autoantigens in hepatitis C virus ( HCV ) infection ."
],
"offsets": [
[
0,
118
]
]
}
] |
[
{
"id": "split_0_train_8660_entity",
"type": "progene_text",
"text": [
"Proteinase 3"
],
"offsets": [
[
0,
12
]
],
"normalized": []
},
{
"id": "split_0_train_8661_entity",
"type": "progene_text",
"text": [
"dihydrolipoamide dehydrogenase"
],
"offsets": [
[
17,
47
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5622
|
split_0_train_5622
|
[
{
"id": "split_0_train_5622_passage",
"type": "progene_text",
"text": [
"Hepatitis C virus ( HCV ) infection has been found to be strikingly associated with autoimmune phenomena ."
],
"offsets": [
[
0,
106
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5623
|
split_0_train_5623
|
[
{
"id": "split_0_train_5623_passage",
"type": "progene_text",
"text": [
"The aim of the present study was to investigate the presence of various autoantibodies in patients with HCV infection ."
],
"offsets": [
[
0,
119
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5624
|
split_0_train_5624
|
[
{
"id": "split_0_train_5624_passage",
"type": "progene_text",
"text": [
"Anti - neutrophil cytoplamic antibody ( ANCA ) , anti - dihydrolipoamide dehydrogenase ( anti - E3 ) , rheumatoid factor ( RF ) , anti - dihydrolipoamide acetyltransferase ( anti - E2 ) , anti - SS-A / Ro ( 60 kD ) , anti - SS-A / Ro ( 52 kD ) , anti - SS-B / La , anti - topoisomerase II ( anti - topo II ) , anti - cardiolipin ( aCL ) , anti - dsDNA , anti - ssDNA , anti - nuclear antibodies ( ANA ) , anti - proteinase 3 ( anti - Pr3 ) and anti - myeloperoxidase ( anti - MPO ) were determined in sera from 516 patients with HCV infection , 11 with primary biliary cirrhosis ( PBC ) and 44 healthy controls ."
],
"offsets": [
[
0,
612
]
]
}
] |
[
{
"id": "split_0_train_8662_entity",
"type": "progene_text",
"text": [
"dihydrolipoamide dehydrogenase"
],
"offsets": [
[
56,
86
]
],
"normalized": []
},
{
"id": "split_0_train_8663_entity",
"type": "progene_text",
"text": [
"rheumatoid factor"
],
"offsets": [
[
103,
120
]
],
"normalized": []
},
{
"id": "split_0_train_8664_entity",
"type": "progene_text",
"text": [
"RF"
],
"offsets": [
[
123,
125
]
],
"normalized": []
},
{
"id": "split_0_train_8665_entity",
"type": "progene_text",
"text": [
"dihydrolipoamide acetyltransferase"
],
"offsets": [
[
137,
171
]
],
"normalized": []
},
{
"id": "split_0_train_8666_entity",
"type": "progene_text",
"text": [
"SS-A"
],
"offsets": [
[
195,
199
]
],
"normalized": []
},
{
"id": "split_0_train_8667_entity",
"type": "progene_text",
"text": [
"Ro ( 60 kD )"
],
"offsets": [
[
202,
214
]
],
"normalized": []
},
{
"id": "split_0_train_8668_entity",
"type": "progene_text",
"text": [
"SS-A"
],
"offsets": [
[
224,
228
]
],
"normalized": []
},
{
"id": "split_0_train_8669_entity",
"type": "progene_text",
"text": [
"Ro ( 52 kD )"
],
"offsets": [
[
231,
243
]
],
"normalized": []
},
{
"id": "split_0_train_8670_entity",
"type": "progene_text",
"text": [
"SS-B"
],
"offsets": [
[
253,
257
]
],
"normalized": []
},
{
"id": "split_0_train_8671_entity",
"type": "progene_text",
"text": [
"La"
],
"offsets": [
[
260,
262
]
],
"normalized": []
},
{
"id": "split_0_train_8672_entity",
"type": "progene_text",
"text": [
"topoisomerase II"
],
"offsets": [
[
272,
288
]
],
"normalized": []
},
{
"id": "split_0_train_8673_entity",
"type": "progene_text",
"text": [
"topo II"
],
"offsets": [
[
298,
305
]
],
"normalized": []
},
{
"id": "split_0_train_8674_entity",
"type": "progene_text",
"text": [
"proteinase 3"
],
"offsets": [
[
412,
424
]
],
"normalized": []
},
{
"id": "split_0_train_8675_entity",
"type": "progene_text",
"text": [
"Pr3"
],
"offsets": [
[
434,
437
]
],
"normalized": []
},
{
"id": "split_0_train_8676_entity",
"type": "progene_text",
"text": [
"myeloperoxidase"
],
"offsets": [
[
451,
466
]
],
"normalized": []
},
{
"id": "split_0_train_8677_entity",
"type": "progene_text",
"text": [
"MPO"
],
"offsets": [
[
476,
479
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5625
|
split_0_train_5625
|
[
{
"id": "split_0_train_5625_passage",
"type": "progene_text",
"text": [
"Assays employed were indirect immunofluoresence , the particle latex agglutination test , enzyme - linked immunosorbent assay ( ELISA ) and immunoblotting ."
],
"offsets": [
[
0,
156
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5626
|
split_0_train_5626
|
[
{
"id": "split_0_train_5626_passage",
"type": "progene_text",
"text": [
"ANCA , anti - E3 antibody and RF were positive in 278 / 516 ( 55.6 % ) , 276 / 516 ( 53.3 % ) and 288 / 516 ( 56 % ) patients with HCV infection , respectively ."
],
"offsets": [
[
0,
161
]
]
}
] |
[
{
"id": "split_0_train_8678_entity",
"type": "progene_text",
"text": [
"RF"
],
"offsets": [
[
30,
32
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5627
|
split_0_train_5627
|
[
{
"id": "split_0_train_5627_passage",
"type": "progene_text",
"text": [
"Positivity for ANA was present in 15.8 % , anti - ssDNA in 15.6 % , anti - dsDNA in 8.5 % , aCL in 5 % , anti - SS - B / La in 4.1 % , anti - SS-A / Ro ( 60 kD ) in 3.9 % , anti - E2 in 3.3 % and anti - SSA / Ro ( 52 kD ) in 1.2 % , anti - MPO in 4.8 % , anti - Topo II and anti - actinin in 0 % ."
],
"offsets": [
[
0,
297
]
]
}
] |
[
{
"id": "split_0_train_8679_entity",
"type": "progene_text",
"text": [
"SS - B"
],
"offsets": [
[
112,
118
]
],
"normalized": []
},
{
"id": "split_0_train_8680_entity",
"type": "progene_text",
"text": [
"La"
],
"offsets": [
[
121,
123
]
],
"normalized": []
},
{
"id": "split_0_train_8681_entity",
"type": "progene_text",
"text": [
"SS-A"
],
"offsets": [
[
142,
146
]
],
"normalized": []
},
{
"id": "split_0_train_8682_entity",
"type": "progene_text",
"text": [
"Ro ( 60 kD )"
],
"offsets": [
[
149,
161
]
],
"normalized": []
},
{
"id": "split_0_train_8683_entity",
"type": "progene_text",
"text": [
"SSA"
],
"offsets": [
[
203,
206
]
],
"normalized": []
},
{
"id": "split_0_train_8684_entity",
"type": "progene_text",
"text": [
"Ro ( 52 kD )"
],
"offsets": [
[
209,
221
]
],
"normalized": []
},
{
"id": "split_0_train_8685_entity",
"type": "progene_text",
"text": [
"MPO"
],
"offsets": [
[
240,
243
]
],
"normalized": []
},
{
"id": "split_0_train_8686_entity",
"type": "progene_text",
"text": [
"Topo II"
],
"offsets": [
[
262,
269
]
],
"normalized": []
},
{
"id": "split_0_train_8687_entity",
"type": "progene_text",
"text": [
"actinin"
],
"offsets": [
[
281,
288
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5628
|
split_0_train_5628
|
[
{
"id": "split_0_train_5628_passage",
"type": "progene_text",
"text": [
"All sera with ANCA showed c-ANCA patterns and contained anti - PR3 specificity ."
],
"offsets": [
[
0,
80
]
]
}
] |
[
{
"id": "split_0_train_8688_entity",
"type": "progene_text",
"text": [
"PR3"
],
"offsets": [
[
63,
66
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5629
|
split_0_train_5629
|
[
{
"id": "split_0_train_5629_passage",
"type": "progene_text",
"text": [
"HCV patients with ANCA showed a higher prevalence of skin involvement , anaemia , abnormal liver function and alpha-Fetoprotein ( alpha-FP ) ."
],
"offsets": [
[
0,
142
]
]
}
] |
[
{
"id": "split_0_train_8689_entity",
"type": "progene_text",
"text": [
"alpha-Fetoprotein"
],
"offsets": [
[
110,
127
]
],
"normalized": []
},
{
"id": "split_0_train_8690_entity",
"type": "progene_text",
"text": [
"alpha-FP"
],
"offsets": [
[
130,
138
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5630
|
split_0_train_5630
|
[
{
"id": "split_0_train_5630_passage",
"type": "progene_text",
"text": [
"HCV patients with anti - E3 antibodies showed a higher prevalence of liver cirrhosis , arthritis , abnormal liver function and elevated alpha-FP levels ."
],
"offsets": [
[
0,
153
]
]
}
] |
[
{
"id": "split_0_train_8691_entity",
"type": "progene_text",
"text": [
"alpha-FP"
],
"offsets": [
[
136,
144
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5631
|
split_0_train_5631
|
[
{
"id": "split_0_train_5631_passage",
"type": "progene_text",
"text": [
"The prevalence of autoantibodies was not affected by treatment with interferon-alpha ( IFN-alpha ) ."
],
"offsets": [
[
0,
100
]
]
}
] |
[
{
"id": "split_0_train_8692_entity",
"type": "progene_text",
"text": [
"interferon-alpha"
],
"offsets": [
[
68,
84
]
],
"normalized": []
},
{
"id": "split_0_train_8693_entity",
"type": "progene_text",
"text": [
"IFN-alpha"
],
"offsets": [
[
87,
96
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5632
|
split_0_train_5632
|
[
{
"id": "split_0_train_5632_passage",
"type": "progene_text",
"text": [
"In conclusion , autoantibodies are commonly found in patients with HCV infection ."
],
"offsets": [
[
0,
82
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5633
|
split_0_train_5633
|
[
{
"id": "split_0_train_5633_passage",
"type": "progene_text",
"text": [
"There is a high prevalence of anti - E3 , ANCA and RF in these patients ."
],
"offsets": [
[
0,
73
]
]
}
] |
[
{
"id": "split_0_train_8694_entity",
"type": "progene_text",
"text": [
"RF"
],
"offsets": [
[
51,
53
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5634
|
split_0_train_5634
|
[
{
"id": "split_0_train_5634_passage",
"type": "progene_text",
"text": [
"Proteinase 3 and E3 are the major target antigens in HCV infection ."
],
"offsets": [
[
0,
68
]
]
}
] |
[
{
"id": "split_0_train_8695_entity",
"type": "progene_text",
"text": [
"Proteinase 3"
],
"offsets": [
[
0,
12
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5635
|
split_0_train_5635
|
[
{
"id": "split_0_train_5635_passage",
"type": "progene_text",
"text": [
"HCV may be regarded as a possible causative factor in ANCA - related vasculitis ."
],
"offsets": [
[
0,
81
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5636
|
split_0_train_5636
|
[
{
"id": "split_0_train_5636_passage",
"type": "progene_text",
"text": [
"The Tol / Pal system function requires an interaction between the C - terminal domain of TolA and the N - terminal domain of TolB ."
],
"offsets": [
[
0,
131
]
]
}
] |
[
{
"id": "split_0_train_8696_entity",
"type": "progene_text",
"text": [
"Tol"
],
"offsets": [
[
4,
7
]
],
"normalized": []
},
{
"id": "split_0_train_8697_entity",
"type": "progene_text",
"text": [
"Pal"
],
"offsets": [
[
10,
13
]
],
"normalized": []
},
{
"id": "split_0_train_8698_entity",
"type": "progene_text",
"text": [
"TolA"
],
"offsets": [
[
89,
93
]
],
"normalized": []
},
{
"id": "split_0_train_8699_entity",
"type": "progene_text",
"text": [
"TolB"
],
"offsets": [
[
125,
129
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5637
|
split_0_train_5637
|
[
{
"id": "split_0_train_5637_passage",
"type": "progene_text",
"text": [
"The Tol / Pal system of Escherichia coli is composed of the YbgC , TolQ , TolA , TolR , TolB , Pal and YbgF proteins ."
],
"offsets": [
[
0,
118
]
]
}
] |
[
{
"id": "split_0_train_8700_entity",
"type": "progene_text",
"text": [
"Tol"
],
"offsets": [
[
4,
7
]
],
"normalized": []
},
{
"id": "split_0_train_8701_entity",
"type": "progene_text",
"text": [
"Pal"
],
"offsets": [
[
10,
13
]
],
"normalized": []
},
{
"id": "split_0_train_8702_entity",
"type": "progene_text",
"text": [
"YbgC"
],
"offsets": [
[
60,
64
]
],
"normalized": []
},
{
"id": "split_0_train_8703_entity",
"type": "progene_text",
"text": [
"TolQ"
],
"offsets": [
[
67,
71
]
],
"normalized": []
},
{
"id": "split_0_train_8704_entity",
"type": "progene_text",
"text": [
"TolA"
],
"offsets": [
[
74,
78
]
],
"normalized": []
},
{
"id": "split_0_train_8705_entity",
"type": "progene_text",
"text": [
"TolR"
],
"offsets": [
[
81,
85
]
],
"normalized": []
},
{
"id": "split_0_train_8706_entity",
"type": "progene_text",
"text": [
"TolB"
],
"offsets": [
[
88,
92
]
],
"normalized": []
},
{
"id": "split_0_train_8707_entity",
"type": "progene_text",
"text": [
"Pal"
],
"offsets": [
[
95,
98
]
],
"normalized": []
},
{
"id": "split_0_train_8708_entity",
"type": "progene_text",
"text": [
"YbgF"
],
"offsets": [
[
103,
107
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5638
|
split_0_train_5638
|
[
{
"id": "split_0_train_5638_passage",
"type": "progene_text",
"text": [
"It is involved in maintaining the integrity of the outer membrane , and is required for the uptake of group A colicins and DNA of filamentous bacteriophages ."
],
"offsets": [
[
0,
158
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5639
|
split_0_train_5639
|
[
{
"id": "split_0_train_5639_passage",
"type": "progene_text",
"text": [
"To identify new interactions between the components of the Tol / Pal system and gain insight into the mechanism of colicin import , we performed a yeast two - hybrid screen using the different components of the Tol / Pal system and colicin A ."
],
"offsets": [
[
0,
243
]
]
}
] |
[
{
"id": "split_0_train_8709_entity",
"type": "progene_text",
"text": [
"Tol"
],
"offsets": [
[
59,
62
]
],
"normalized": []
},
{
"id": "split_0_train_8710_entity",
"type": "progene_text",
"text": [
"Pal"
],
"offsets": [
[
65,
68
]
],
"normalized": []
},
{
"id": "split_0_train_8711_entity",
"type": "progene_text",
"text": [
"Tol"
],
"offsets": [
[
211,
214
]
],
"normalized": []
},
{
"id": "split_0_train_8712_entity",
"type": "progene_text",
"text": [
"Pal"
],
"offsets": [
[
217,
220
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5640
|
split_0_train_5640
|
[
{
"id": "split_0_train_5640_passage",
"type": "progene_text",
"text": [
"Using this system , we confirmed the already known interactions and identified several new interactions ."
],
"offsets": [
[
0,
105
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5641
|
split_0_train_5641
|
[
{
"id": "split_0_train_5641_passage",
"type": "progene_text",
"text": [
"TolB dimerizes and the periplasmic domain of TolA interacts with YbgF and TolB ."
],
"offsets": [
[
0,
80
]
]
}
] |
[
{
"id": "split_0_train_8713_entity",
"type": "progene_text",
"text": [
"TolB"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_8714_entity",
"type": "progene_text",
"text": [
"TolA"
],
"offsets": [
[
45,
49
]
],
"normalized": []
},
{
"id": "split_0_train_8715_entity",
"type": "progene_text",
"text": [
"YbgF"
],
"offsets": [
[
65,
69
]
],
"normalized": []
},
{
"id": "split_0_train_8716_entity",
"type": "progene_text",
"text": [
"TolB"
],
"offsets": [
[
74,
78
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5642
|
split_0_train_5642
|
[
{
"id": "split_0_train_5642_passage",
"type": "progene_text",
"text": [
"Our results indicate that the central domain of TolA ( TolAII ) is sufficient to interact with YbgF , that the C - terminal domain of TolA ( TolAIII ) is sufficient to interact with TolB , and that the amino terminal domain of TolB ( D1 ) is sufficient to bind TolAIII ."
],
"offsets": [
[
0,
270
]
]
}
] |
[
{
"id": "split_0_train_8717_entity",
"type": "progene_text",
"text": [
"TolA"
],
"offsets": [
[
48,
52
]
],
"normalized": []
},
{
"id": "split_0_train_8718_entity",
"type": "progene_text",
"text": [
"YbgF"
],
"offsets": [
[
95,
99
]
],
"normalized": []
},
{
"id": "split_0_train_8719_entity",
"type": "progene_text",
"text": [
"TolA"
],
"offsets": [
[
134,
138
]
],
"normalized": []
},
{
"id": "split_0_train_8720_entity",
"type": "progene_text",
"text": [
"TolB"
],
"offsets": [
[
182,
186
]
],
"normalized": []
},
{
"id": "split_0_train_8721_entity",
"type": "progene_text",
"text": [
"TolB"
],
"offsets": [
[
227,
231
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5643
|
split_0_train_5643
|
[
{
"id": "split_0_train_5643_passage",
"type": "progene_text",
"text": [
"The TolA / TolB interaction was confirmed by cross - linking experiments on purified proteins ."
],
"offsets": [
[
0,
95
]
]
}
] |
[
{
"id": "split_0_train_8722_entity",
"type": "progene_text",
"text": [
"TolA"
],
"offsets": [
[
4,
8
]
],
"normalized": []
},
{
"id": "split_0_train_8723_entity",
"type": "progene_text",
"text": [
"TolB"
],
"offsets": [
[
11,
15
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5644
|
split_0_train_5644
|
[
{
"id": "split_0_train_5644_passage",
"type": "progene_text",
"text": [
"Moreover , we show that the interaction between TolA and TolB is required for the uptake of colicin A and for the membrane integrity ."
],
"offsets": [
[
0,
134
]
]
}
] |
[
{
"id": "split_0_train_8724_entity",
"type": "progene_text",
"text": [
"TolA"
],
"offsets": [
[
48,
52
]
],
"normalized": []
},
{
"id": "split_0_train_8725_entity",
"type": "progene_text",
"text": [
"TolB"
],
"offsets": [
[
57,
61
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5645
|
split_0_train_5645
|
[
{
"id": "split_0_train_5645_passage",
"type": "progene_text",
"text": [
"These results demonstrate that the TolA / TolB interaction allows the formation of a trans - envelope complex that brings the inner and outer membranes in close proximity ."
],
"offsets": [
[
0,
172
]
]
}
] |
[
{
"id": "split_0_train_8726_entity",
"type": "progene_text",
"text": [
"TolA"
],
"offsets": [
[
35,
39
]
],
"normalized": []
},
{
"id": "split_0_train_8727_entity",
"type": "progene_text",
"text": [
"TolB"
],
"offsets": [
[
42,
46
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5646
|
split_0_train_5646
|
[
{
"id": "split_0_train_5646_passage",
"type": "progene_text",
"text": [
"Inactivating mutations of CASP10 gene in non - Hodgkin lymphomas ."
],
"offsets": [
[
0,
66
]
]
}
] |
[
{
"id": "split_0_train_8728_entity",
"type": "progene_text",
"text": [
"CASP10"
],
"offsets": [
[
26,
32
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5647
|
split_0_train_5647
|
[
{
"id": "split_0_train_5647_passage",
"type": "progene_text",
"text": [
"Caspase 10 ( Mch4 / FLICE2 ) is a caspase homologous to caspase 8 ."
],
"offsets": [
[
0,
67
]
]
}
] |
[
{
"id": "split_0_train_8729_entity",
"type": "progene_text",
"text": [
"Caspase 10"
],
"offsets": [
[
0,
10
]
],
"normalized": []
},
{
"id": "split_0_train_8730_entity",
"type": "progene_text",
"text": [
"Mch4"
],
"offsets": [
[
13,
17
]
],
"normalized": []
},
{
"id": "split_0_train_8731_entity",
"type": "progene_text",
"text": [
"FLICE2"
],
"offsets": [
[
20,
26
]
],
"normalized": []
},
{
"id": "split_0_train_8732_entity",
"type": "progene_text",
"text": [
"caspase 8"
],
"offsets": [
[
56,
65
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5648
|
split_0_train_5648
|
[
{
"id": "split_0_train_5648_passage",
"type": "progene_text",
"text": [
"A recent report described that inherited CASP10 gene mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome ( ALPS ) ."
],
"offsets": [
[
0,
175
]
]
}
] |
[
{
"id": "split_0_train_8733_entity",
"type": "progene_text",
"text": [
"CASP10"
],
"offsets": [
[
41,
47
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5649
|
split_0_train_5649
|
[
{
"id": "split_0_train_5649_passage",
"type": "progene_text",
"text": [
"In this study , to explore the possibility that mutation of this gene might be involved in the development of non - Hodgkin lymphoma ( NHL ) , we have analyzed the entire coding region and all splice sites of the CASP10 gene for the detection of somatic mutations in 117 human NHLs ."
],
"offsets": [
[
0,
283
]
]
}
] |
[
{
"id": "split_0_train_8734_entity",
"type": "progene_text",
"text": [
"CASP10"
],
"offsets": [
[
213,
219
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5650
|
split_0_train_5650
|
[
{
"id": "split_0_train_5650_passage",
"type": "progene_text",
"text": [
"Overall , 17 NHLs ( 14.5 % ) were found to have CASP10 mutations , which were identified in the coding regions of the prodomain ( n = 3 ) , the p17 large protease subunit ( n = 11 ) , and the p12 small protease subunit ( n = 3 ) ."
],
"offsets": [
[
0,
230
]
]
}
] |
[
{
"id": "split_0_train_8735_entity",
"type": "progene_text",
"text": [
"CASP10"
],
"offsets": [
[
48,
54
]
],
"normalized": []
},
{
"id": "split_0_train_8736_entity",
"type": "progene_text",
"text": [
"protease"
],
"offsets": [
[
154,
162
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5651
|
split_0_train_5651
|
[
{
"id": "split_0_train_5651_passage",
"type": "progene_text",
"text": [
"We expressed the tumor - derived caspase 10 mutants in 293 cells and found that apoptosis was suppressed ."
],
"offsets": [
[
0,
106
]
]
}
] |
[
{
"id": "split_0_train_8737_entity",
"type": "progene_text",
"text": [
"caspase 10"
],
"offsets": [
[
33,
43
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5652
|
split_0_train_5652
|
[
{
"id": "split_0_train_5652_passage",
"type": "progene_text",
"text": [
"These data suggest that the inactivating mutations of the CASP10 gene might lead to the loss of its apoptotic function and contribute to the pathogenesis of some human NHLs ."
],
"offsets": [
[
0,
174
]
]
}
] |
[
{
"id": "split_0_train_8738_entity",
"type": "progene_text",
"text": [
"CASP10"
],
"offsets": [
[
58,
64
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5653
|
split_0_train_5653
|
[
{
"id": "split_0_train_5653_passage",
"type": "progene_text",
"text": [
"Photoreceptor renewal : a role for peripherin / rds ."
],
"offsets": [
[
0,
53
]
]
}
] |
[
{
"id": "split_0_train_8739_entity",
"type": "progene_text",
"text": [
"Photoreceptor"
],
"offsets": [
[
0,
13
]
],
"normalized": []
},
{
"id": "split_0_train_8740_entity",
"type": "progene_text",
"text": [
"peripherin"
],
"offsets": [
[
35,
45
]
],
"normalized": []
},
{
"id": "split_0_train_8741_entity",
"type": "progene_text",
"text": [
"rds"
],
"offsets": [
[
48,
51
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5654
|
split_0_train_5654
|
[
{
"id": "split_0_train_5654_passage",
"type": "progene_text",
"text": [
"Visual transduction begins with the detection of light within the photoreceptor cell layer of the retina ."
],
"offsets": [
[
0,
106
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5655
|
split_0_train_5655
|
[
{
"id": "split_0_train_5655_passage",
"type": "progene_text",
"text": [
"Within this layer , specialized cells , termed rods and cones , contain the proteins responsible for light capture and its transduction to nerve impulses ."
],
"offsets": [
[
0,
155
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5656
|
split_0_train_5656
|
[
{
"id": "split_0_train_5656_passage",
"type": "progene_text",
"text": [
"The phototransductive proteins reside within an outer segment region that is connected to an inner segment by a thin stalk rich in cytoskeletal elements ."
],
"offsets": [
[
0,
154
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5657
|
split_0_train_5657
|
[
{
"id": "split_0_train_5657_passage",
"type": "progene_text",
"text": [
"A unique property of the outer segments is the presence of an elaborate intracellular membrane system that holds the phototransduction proteins and provides the requisite lipid environment ."
],
"offsets": [
[
0,
190
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5658
|
split_0_train_5658
|
[
{
"id": "split_0_train_5658_passage",
"type": "progene_text",
"text": [
"The maintenance of normal physiological function requires that these postmitotic cells retain the unique structure of the outer segment regions -- stacks of membrane saccules in the case of rods and a continuous infolding of membrane in the case of cones ."
],
"offsets": [
[
0,
256
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5659
|
split_0_train_5659
|
[
{
"id": "split_0_train_5659_passage",
"type": "progene_text",
"text": [
"Both photoreceptor rod and cone cells achieve this through a series of coordinated steps ."
],
"offsets": [
[
0,
90
]
]
}
] |
[
{
"id": "split_0_train_8742_entity",
"type": "progene_text",
"text": [
"photoreceptor"
],
"offsets": [
[
5,
18
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5660
|
split_0_train_5660
|
[
{
"id": "split_0_train_5660_passage",
"type": "progene_text",
"text": [
"As new membranous material is synthesized , transported , and incorporated into newly forming outer segment membranes , a compensatory shedding of older membranous material occurs , thereby maintaining the segment at a constant length ."
],
"offsets": [
[
0,
236
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5661
|
split_0_train_5661
|
[
{
"id": "split_0_train_5661_passage",
"type": "progene_text",
"text": [
"These processes are collectively referred to as ROS ( rod outer segment ) or COS ( cone outer segment ) renewal ."
],
"offsets": [
[
0,
113
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5662
|
split_0_train_5662
|
[
{
"id": "split_0_train_5662_passage",
"type": "progene_text",
"text": [
"We review the cellular and molecular events responsible for these renewal processes and present the recent but compelling evidence , drawn from molecular genetic , biochemical , and biophysical approaches , pointing to an essential role for a unique tetraspanning membrane protein , called peripherin / rds , in the processes of disk morphogenesis ."
],
"offsets": [
[
0,
349
]
]
}
] |
[
{
"id": "split_0_train_8743_entity",
"type": "progene_text",
"text": [
"peripherin"
],
"offsets": [
[
290,
300
]
],
"normalized": []
},
{
"id": "split_0_train_8744_entity",
"type": "progene_text",
"text": [
"rds"
],
"offsets": [
[
303,
306
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5663
|
split_0_train_5663
|
[
{
"id": "split_0_train_5663_passage",
"type": "progene_text",
"text": [
"Human uroplakin lb gene structure and promoter analysis ."
],
"offsets": [
[
0,
57
]
]
}
] |
[
{
"id": "split_0_train_8745_entity",
"type": "progene_text",
"text": [
"uroplakin lb"
],
"offsets": [
[
6,
18
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5664
|
split_0_train_5664
|
[
{
"id": "split_0_train_5664_passage",
"type": "progene_text",
"text": [
"The uroplakin Ib ( UPIb ) gene is predominantly expressed in urothelium and is overexpressed in 50 % of transitional cell carcinoma ( TCC ) ."
],
"offsets": [
[
0,
141
]
]
}
] |
[
{
"id": "split_0_train_8746_entity",
"type": "progene_text",
"text": [
"uroplakin Ib"
],
"offsets": [
[
4,
16
]
],
"normalized": []
},
{
"id": "split_0_train_8747_entity",
"type": "progene_text",
"text": [
"UPIb"
],
"offsets": [
[
19,
23
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5665
|
split_0_train_5665
|
[
{
"id": "split_0_train_5665_passage",
"type": "progene_text",
"text": [
"Molecular cloning of the genomic 5' region and comparison to a chromosome 3q genomic contig determined that the gene spans 31 kb and has eight exons including a noncoding exon 1 ."
],
"offsets": [
[
0,
179
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5666
|
split_0_train_5666
|
[
{
"id": "split_0_train_5666_passage",
"type": "progene_text",
"text": [
"Multiple transcription start sites were identified in exon 1 by 5'RACE and ribonuclease protection assay ( RPA ) ."
],
"offsets": [
[
0,
114
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5667
|
split_0_train_5667
|
[
{
"id": "split_0_train_5667_passage",
"type": "progene_text",
"text": [
"In vitro reporter gene analysis was performed with 2.3 kb of genomic DNA sequence flanking the 5' end of UPIb ."
],
"offsets": [
[
0,
111
]
]
}
] |
[
{
"id": "split_0_train_8748_entity",
"type": "progene_text",
"text": [
"UPIb"
],
"offsets": [
[
105,
109
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5668
|
split_0_train_5668
|
[
{
"id": "split_0_train_5668_passage",
"type": "progene_text",
"text": [
"A 235 - bp 5' fragment that included UPIb exon 1 generated strong transcriptional activity in normal and malignant human urothelial cell lines ."
],
"offsets": [
[
0,
144
]
]
}
] |
[
{
"id": "split_0_train_8749_entity",
"type": "progene_text",
"text": [
"UPIb"
],
"offsets": [
[
37,
41
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5669
|
split_0_train_5669
|
[
{
"id": "split_0_train_5669_passage",
"type": "progene_text",
"text": [
"Established malignant cell lines had greater transcriptional activity from the UPIb promoter than normal human cells ."
],
"offsets": [
[
0,
118
]
]
}
] |
[
{
"id": "split_0_train_8750_entity",
"type": "progene_text",
"text": [
"UPIb"
],
"offsets": [
[
79,
83
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5670
|
split_0_train_5670
|
[
{
"id": "split_0_train_5670_passage",
"type": "progene_text",
"text": [
"The identification of a functional human UPIb gene promoter may find application in targeting gene therapy strategies for bladder cancer ."
],
"offsets": [
[
0,
138
]
]
}
] |
[
{
"id": "split_0_train_8751_entity",
"type": "progene_text",
"text": [
"UPIb"
],
"offsets": [
[
41,
45
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5671
|
split_0_train_5671
|
[
{
"id": "split_0_train_5671_passage",
"type": "progene_text",
"text": [
"Normalization of natural killer cell function and phenotype with effective anti - HIV therapy and the role of IL-10 ."
],
"offsets": [
[
0,
117
]
]
}
] |
[
{
"id": "split_0_train_8752_entity",
"type": "progene_text",
"text": [
"IL-10"
],
"offsets": [
[
110,
115
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5672
|
split_0_train_5672
|
[
{
"id": "split_0_train_5672_passage",
"type": "progene_text",
"text": [
"OBJECTIVES :"
],
"offsets": [
[
0,
12
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5673
|
split_0_train_5673
|
[
{
"id": "split_0_train_5673_passage",
"type": "progene_text",
"text": [
"Natural killer ( NK ) cell function is likely to be important in controlling HIV infection and opportunistic pathogens ."
],
"offsets": [
[
0,
120
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5674
|
split_0_train_5674
|
[
{
"id": "split_0_train_5674_passage",
"type": "progene_text",
"text": [
"We therefore evaluated NK function and phenotype over the course of antiretroviral therapy ( ART ) and examined the potential mechanisms of altered NK activity in HIV infection ."
],
"offsets": [
[
0,
178
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5675
|
split_0_train_5675
|
[
{
"id": "split_0_train_5675_passage",
"type": "progene_text",
"text": [
"METHODS :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5676
|
split_0_train_5676
|
[
{
"id": "split_0_train_5676_passage",
"type": "progene_text",
"text": [
"We measured NK cell percentage , NK cytolytic activity ( both by flow cytometry ) and plasma IL-10 concentrations ( by enzyme - linked immunosorbent assay ) in 10 HIV - seropositive patients before and over one year of effective ART ."
],
"offsets": [
[
0,
234
]
]
}
] |
[
{
"id": "split_0_train_8753_entity",
"type": "progene_text",
"text": [
"IL-10"
],
"offsets": [
[
93,
98
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5677
|
split_0_train_5677
|
[
{
"id": "split_0_train_5677_passage",
"type": "progene_text",
"text": [
"To examine potential mechanisms of altered NK activity , we measured NK receptor expression in ART treated and untreated HIV - positive individuals by flow cytometry ."
],
"offsets": [
[
0,
167
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5678
|
split_0_train_5678
|
[
{
"id": "split_0_train_5678_passage",
"type": "progene_text",
"text": [
"As IL-10 enhances NK activity , we studied the effect of IL-10 on NK receptor expression and activity in peripheral blood mononuclear cells ( PBMC ) from HIV - seronegative individuals ."
],
"offsets": [
[
0,
186
]
]
}
] |
[
{
"id": "split_0_train_8754_entity",
"type": "progene_text",
"text": [
"IL-10"
],
"offsets": [
[
3,
8
]
],
"normalized": []
},
{
"id": "split_0_train_8755_entity",
"type": "progene_text",
"text": [
"IL-10"
],
"offsets": [
[
57,
62
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5679
|
split_0_train_5679
|
[
{
"id": "split_0_train_5679_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5680
|
split_0_train_5680
|
[
{
"id": "split_0_train_5680_passage",
"type": "progene_text",
"text": [
"NK cytolytic activity was elevated in HIV infection and decreased with ART to levels observed in HIV - negative individuals ."
],
"offsets": [
[
0,
125
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5681
|
split_0_train_5681
|
[
{
"id": "split_0_train_5681_passage",
"type": "progene_text",
"text": [
"A greater proportion of NK cells from untreated HIV - positive individuals expressed the NK receptors CD158a and CD161 than either HIV - negative volunteers or effectively treated HIV - positive patients ."
],
"offsets": [
[
0,
205
]
]
}
] |
[
{
"id": "split_0_train_8756_entity",
"type": "progene_text",
"text": [
"CD158a"
],
"offsets": [
[
102,
108
]
],
"normalized": []
},
{
"id": "split_0_train_8757_entity",
"type": "progene_text",
"text": [
"CD161"
],
"offsets": [
[
113,
118
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5682
|
split_0_train_5682
|
[
{
"id": "split_0_train_5682_passage",
"type": "progene_text",
"text": [
"NK cells from PBMC incubated with IL-10 demonstrated increases in CD158a , CD161 and CD94 expression and increases in cytolytic activity ."
],
"offsets": [
[
0,
138
]
]
}
] |
[
{
"id": "split_0_train_8758_entity",
"type": "progene_text",
"text": [
"IL-10"
],
"offsets": [
[
34,
39
]
],
"normalized": []
},
{
"id": "split_0_train_8759_entity",
"type": "progene_text",
"text": [
"CD158a"
],
"offsets": [
[
66,
72
]
],
"normalized": []
},
{
"id": "split_0_train_8760_entity",
"type": "progene_text",
"text": [
"CD161"
],
"offsets": [
[
75,
80
]
],
"normalized": []
},
{
"id": "split_0_train_8761_entity",
"type": "progene_text",
"text": [
"CD94"
],
"offsets": [
[
85,
89
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5683
|
split_0_train_5683
|
[
{
"id": "split_0_train_5683_passage",
"type": "progene_text",
"text": [
"The treatment - associated decrease in NK activity paralleled a decrease in IL-10 production ."
],
"offsets": [
[
0,
94
]
]
}
] |
[
{
"id": "split_0_train_8762_entity",
"type": "progene_text",
"text": [
"IL-10"
],
"offsets": [
[
76,
81
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5684
|
split_0_train_5684
|
[
{
"id": "split_0_train_5684_passage",
"type": "progene_text",
"text": [
"CONCLUSION :"
],
"offsets": [
[
0,
12
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5685
|
split_0_train_5685
|
[
{
"id": "split_0_train_5685_passage",
"type": "progene_text",
"text": [
"The observation that IL-10 alters NK receptor expression similar to that observed in HIV infection , and the fact that NK receptor expression and activity normalize in parallel with ART - induced reduction of circulating IL-10 levels supports a role for IL-10 in NK cell activity and HIV immunopathogenesis ."
],
"offsets": [
[
0,
308
]
]
}
] |
[
{
"id": "split_0_train_8763_entity",
"type": "progene_text",
"text": [
"IL-10"
],
"offsets": [
[
21,
26
]
],
"normalized": []
},
{
"id": "split_0_train_8764_entity",
"type": "progene_text",
"text": [
"IL-10"
],
"offsets": [
[
221,
226
]
],
"normalized": []
},
{
"id": "split_0_train_8765_entity",
"type": "progene_text",
"text": [
"IL-10"
],
"offsets": [
[
254,
259
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5686
|
split_0_train_5686
|
[
{
"id": "split_0_train_5686_passage",
"type": "progene_text",
"text": [
"Molecular misreading of the ubiquitin B gene and hepatic mallory body formation ."
],
"offsets": [
[
0,
81
]
]
}
] |
[
{
"id": "split_0_train_8766_entity",
"type": "progene_text",
"text": [
"ubiquitin B"
],
"offsets": [
[
28,
39
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5687
|
split_0_train_5687
|
[
{
"id": "split_0_train_5687_passage",
"type": "progene_text",
"text": [
"BACKGROUND & AIMS :"
],
"offsets": [
[
0,
19
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5688
|
split_0_train_5688
|
[
{
"id": "split_0_train_5688_passage",
"type": "progene_text",
"text": [
"Molecular misreading of the ubiquitin B gene has been documented in the cerebral cortex of patients with Alzheimer 's disease and Down syndrome ."
],
"offsets": [
[
0,
145
]
]
}
] |
[
{
"id": "split_0_train_8767_entity",
"type": "progene_text",
"text": [
"ubiquitin B"
],
"offsets": [
[
28,
39
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5689
|
split_0_train_5689
|
[
{
"id": "split_0_train_5689_passage",
"type": "progene_text",
"text": [
"This novel process consists of the unfaithful conversion of genomic information into aberrant transcripts and its subsequent translation into + 1 proteins ."
],
"offsets": [
[
0,
156
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5690
|
split_0_train_5690
|
[
{
"id": "split_0_train_5690_passage",
"type": "progene_text",
"text": [
"METHODS :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5691
|
split_0_train_5691
|
[
{
"id": "split_0_train_5691_passage",
"type": "progene_text",
"text": [
"Because Mallory bodies ( MBs ) also contain ubiquitinated proteins , we stained 11 autopsied and 6 biopsied MB - containing livers from patients with steatohepatitis with an antibody to ubiquitin (+1) to look for the presence of mutant ( ubiquitin (+1) ) protein ."
],
"offsets": [
[
0,
264
]
]
}
] |
[
{
"id": "split_0_train_8768_entity",
"type": "progene_text",
"text": [
"ubiquitin"
],
"offsets": [
[
186,
195
]
],
"normalized": []
},
{
"id": "split_0_train_8769_entity",
"type": "progene_text",
"text": [
"ubiquitin"
],
"offsets": [
[
238,
247
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5692
|
split_0_train_5692
|
[
{
"id": "split_0_train_5692_passage",
"type": "progene_text",
"text": [
"Antibodies to wild - type ubiquitin were used to document the presence of MBs in all cases ."
],
"offsets": [
[
0,
92
]
]
}
] |
[
{
"id": "split_0_train_8770_entity",
"type": "progene_text",
"text": [
"ubiquitin"
],
"offsets": [
[
26,
35
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5693
|
split_0_train_5693
|
[
{
"id": "split_0_train_5693_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5694
|
split_0_train_5694
|
[
{
"id": "split_0_train_5694_passage",
"type": "progene_text",
"text": [
"Ubiquitin (+1) immunoreactivity was detected in all MB - containing livers with steatohepatitis ; no ubiquitin (+1) immunoreactivity was found in 13 MB - free liver controls ."
],
"offsets": [
[
0,
175
]
]
}
] |
[
{
"id": "split_0_train_8771_entity",
"type": "progene_text",
"text": [
"Ubiquitin"
],
"offsets": [
[
0,
9
]
],
"normalized": []
},
{
"id": "split_0_train_8772_entity",
"type": "progene_text",
"text": [
"ubiquitin"
],
"offsets": [
[
101,
110
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5695
|
split_0_train_5695
|
[
{
"id": "split_0_train_5695_passage",
"type": "progene_text",
"text": [
"A subpopulation ( about one third of the MBs ) of the MB - containing hepatocytes in autopsied livers showed ubiquitin ( +1) immunoreactivity ( i.e. , ubiquitin and ubiquitin ( +1) colocalized in MBs ) ."
],
"offsets": [
[
0,
203
]
]
}
] |
[
{
"id": "split_0_train_8773_entity",
"type": "progene_text",
"text": [
"ubiquitin"
],
"offsets": [
[
109,
118
]
],
"normalized": []
},
{
"id": "split_0_train_8774_entity",
"type": "progene_text",
"text": [
"ubiquitin"
],
"offsets": [
[
151,
160
]
],
"normalized": []
},
{
"id": "split_0_train_8775_entity",
"type": "progene_text",
"text": [
"ubiquitin"
],
"offsets": [
[
165,
174
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5696
|
split_0_train_5696
|
[
{
"id": "split_0_train_5696_passage",
"type": "progene_text",
"text": [
"MB - containing liver biopsy specimens showed colocalization of ubiquitin and ubiquitin (+1) in every MB ."
],
"offsets": [
[
0,
106
]
]
}
] |
[
{
"id": "split_0_train_8776_entity",
"type": "progene_text",
"text": [
"ubiquitin"
],
"offsets": [
[
64,
73
]
],
"normalized": []
},
{
"id": "split_0_train_8777_entity",
"type": "progene_text",
"text": [
"ubiquitin"
],
"offsets": [
[
78,
87
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5697
|
split_0_train_5697
|
[
{
"id": "split_0_train_5697_passage",
"type": "progene_text",
"text": [
"Western blot analysis showed an ubiquitin (+1) band of 11 kilodaltons ."
],
"offsets": [
[
0,
71
]
]
}
] |
[
{
"id": "split_0_train_8778_entity",
"type": "progene_text",
"text": [
"ubiquitin"
],
"offsets": [
[
32,
41
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5698
|
split_0_train_5698
|
[
{
"id": "split_0_train_5698_passage",
"type": "progene_text",
"text": [
"Molecular misreading of the ubiquitin B gene ( DeltaGU ) was shown in one of the livers , which contained numerous MBs using an expression cloning strategy ."
],
"offsets": [
[
0,
157
]
]
}
] |
[
{
"id": "split_0_train_8779_entity",
"type": "progene_text",
"text": [
"ubiquitin B"
],
"offsets": [
[
28,
39
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5699
|
split_0_train_5699
|
[
{
"id": "split_0_train_5699_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
] |
[] |
[] |
[] |
[] |
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