id
stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
split_0_train_5900
|
split_0_train_5900
|
[
{
"id": "split_0_train_5900_passage",
"type": "progene_text",
"text": [
"Impairment of PTTG regulated functions is expected to lead to chromosomal instability and aneuploidy ."
],
"offsets": [
[
0,
102
]
]
}
] |
[
{
"id": "split_0_train_9131_entity",
"type": "progene_text",
"text": [
"PTTG"
],
"offsets": [
[
14,
18
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5901
|
split_0_train_5901
|
[
{
"id": "split_0_train_5901_passage",
"type": "progene_text",
"text": [
"Human pttg ( hpttg ) is abundantly expressed in Jurkat T lymphoblastic lymphoma cells but not in normal peripheral blood leukocytes ."
],
"offsets": [
[
0,
133
]
]
}
] |
[
{
"id": "split_0_train_9132_entity",
"type": "progene_text",
"text": [
"pttg"
],
"offsets": [
[
6,
10
]
],
"normalized": []
},
{
"id": "split_0_train_9133_entity",
"type": "progene_text",
"text": [
"hpttg"
],
"offsets": [
[
13,
18
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5902
|
split_0_train_5902
|
[
{
"id": "split_0_train_5902_passage",
"type": "progene_text",
"text": [
"To obtain additional data on the potential role of hpttg in lymphomagenesis we selected 150 cases of lymphoid tumors for the assessment of hpttg expression in tumor tissues ."
],
"offsets": [
[
0,
174
]
]
}
] |
[
{
"id": "split_0_train_9134_entity",
"type": "progene_text",
"text": [
"hpttg"
],
"offsets": [
[
51,
56
]
],
"normalized": []
},
{
"id": "split_0_train_9135_entity",
"type": "progene_text",
"text": [
"hpttg"
],
"offsets": [
[
139,
144
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5903
|
split_0_train_5903
|
[
{
"id": "split_0_train_5903_passage",
"type": "progene_text",
"text": [
"Immunohistochemical studies on formalin - fixed , paraffin - embedded tissues revealed hPTTG in 38.8 % of B-cell lymphomas , 70.2 % of T-cell lymphomas , and 73.1 % of Hodgkin 's lymphomas ."
],
"offsets": [
[
0,
190
]
]
}
] |
[
{
"id": "split_0_train_9136_entity",
"type": "progene_text",
"text": [
"hPTTG"
],
"offsets": [
[
87,
92
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5904
|
split_0_train_5904
|
[
{
"id": "split_0_train_5904_passage",
"type": "progene_text",
"text": [
"Among B-cell lymphomas , the most frequently immunostained tumors were plasma cell tumors , diffuse large cell lymphomas , and follicle center cell lymphomas ."
],
"offsets": [
[
0,
159
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5905
|
split_0_train_5905
|
[
{
"id": "split_0_train_5905_passage",
"type": "progene_text",
"text": [
"In Hodgkin 's disease , immunoreactivity was mainly noted in Reed - Sternberg cells ."
],
"offsets": [
[
0,
85
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5906
|
split_0_train_5906
|
[
{
"id": "split_0_train_5906_passage",
"type": "progene_text",
"text": [
"In conclusion , the frequent overexpression of hpttg in many histological subtypes of lymphoma suggests the involvement of this proto - oncogene in lymphomagenesis ."
],
"offsets": [
[
0,
165
]
]
}
] |
[
{
"id": "split_0_train_9137_entity",
"type": "progene_text",
"text": [
"hpttg"
],
"offsets": [
[
47,
52
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5907
|
split_0_train_5907
|
[
{
"id": "split_0_train_5907_passage",
"type": "progene_text",
"text": [
"Effects of dehydration on endocrine regulation of the electrolyte and fluid balance and atrial natriuretic peptide - binding sites in perinatally malnourished adult male rats ."
],
"offsets": [
[
0,
176
]
]
}
] |
[
{
"id": "split_0_train_9138_entity",
"type": "progene_text",
"text": [
"atrial natriuretic peptide"
],
"offsets": [
[
88,
114
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5908
|
split_0_train_5908
|
[
{
"id": "split_0_train_5908_passage",
"type": "progene_text",
"text": [
"OBJECTIVE :"
],
"offsets": [
[
0,
11
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5909
|
split_0_train_5909
|
[
{
"id": "split_0_train_5909_passage",
"type": "progene_text",
"text": [
"The first aim of this work was to investigate , under basal conditions in adult male rats , the long - term consequences of perinatal maternal food restriction on the plasma concentrations of vasopressin ( VP ) , aldosterone and atrial natriuretic peptide ( ANP ) and on plasma renin activity ( PRA ) ."
],
"offsets": [
[
0,
302
]
]
}
] |
[
{
"id": "split_0_train_9139_entity",
"type": "progene_text",
"text": [
"vasopressin"
],
"offsets": [
[
192,
203
]
],
"normalized": []
},
{
"id": "split_0_train_9140_entity",
"type": "progene_text",
"text": [
"VP"
],
"offsets": [
[
206,
208
]
],
"normalized": []
},
{
"id": "split_0_train_9141_entity",
"type": "progene_text",
"text": [
"atrial natriuretic peptide"
],
"offsets": [
[
229,
255
]
],
"normalized": []
},
{
"id": "split_0_train_9142_entity",
"type": "progene_text",
"text": [
"ANP"
],
"offsets": [
[
258,
261
]
],
"normalized": []
},
{
"id": "split_0_train_9143_entity",
"type": "progene_text",
"text": [
"renin"
],
"offsets": [
[
278,
283
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5910
|
split_0_train_5910
|
[
{
"id": "split_0_train_5910_passage",
"type": "progene_text",
"text": [
"Furthermore , under these same conditions , the hypothalamic VP gene expression as well as the density ( B(max) ) , affinity ( K(d) ) and gene expression of ANP receptors were determined in kidneys and adrenals ."
],
"offsets": [
[
0,
212
]
]
}
] |
[
{
"id": "split_0_train_9144_entity",
"type": "progene_text",
"text": [
"VP"
],
"offsets": [
[
61,
63
]
],
"normalized": []
},
{
"id": "split_0_train_9145_entity",
"type": "progene_text",
"text": [
"ANP receptors"
],
"offsets": [
[
157,
170
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5911
|
split_0_train_5911
|
[
{
"id": "split_0_train_5911_passage",
"type": "progene_text",
"text": [
"The second aim of this work was to examine the responsiveness to dehydration in perinatally malnourished rats ."
],
"offsets": [
[
0,
111
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5912
|
split_0_train_5912
|
[
{
"id": "split_0_train_5912_passage",
"type": "progene_text",
"text": [
"Thus , the latter parameters were studied in these rats after 72 h water deprivation ."
],
"offsets": [
[
0,
86
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5913
|
split_0_train_5913
|
[
{
"id": "split_0_train_5913_passage",
"type": "progene_text",
"text": [
"METHODS :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5914
|
split_0_train_5914
|
[
{
"id": "split_0_train_5914_passage",
"type": "progene_text",
"text": [
"This study was conducted on 4 - Month - old male rats from mothers exposed to 50 % food restriction ( FR50 ) during the last week of gestation and lactation and on age - matched control animals ( C ) ."
],
"offsets": [
[
0,
201
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5915
|
split_0_train_5915
|
[
{
"id": "split_0_train_5915_passage",
"type": "progene_text",
"text": [
"At this stage , both C and FR50 rats were killed by decapitation between 0900 h and 1000 h in order to determine parameters under basal conditions or after 72 h water deprivation ."
],
"offsets": [
[
0,
180
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5916
|
split_0_train_5916
|
[
{
"id": "split_0_train_5916_passage",
"type": "progene_text",
"text": [
"Plasma VP , ANP and aldosterone levels and PRA were determined by radioimmunoassay ."
],
"offsets": [
[
0,
84
]
]
}
] |
[
{
"id": "split_0_train_9146_entity",
"type": "progene_text",
"text": [
"VP"
],
"offsets": [
[
7,
9
]
],
"normalized": []
},
{
"id": "split_0_train_9147_entity",
"type": "progene_text",
"text": [
"ANP"
],
"offsets": [
[
12,
15
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5917
|
split_0_train_5917
|
[
{
"id": "split_0_train_5917_passage",
"type": "progene_text",
"text": [
"Hypothalamic VP gene expression was determined in the paraventricular nucleus ( PVN ) and supraoptic nucleus ( SON ) by in situ hybridization ."
],
"offsets": [
[
0,
143
]
]
}
] |
[
{
"id": "split_0_train_9148_entity",
"type": "progene_text",
"text": [
"VP"
],
"offsets": [
[
13,
15
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5918
|
split_0_train_5918
|
[
{
"id": "split_0_train_5918_passage",
"type": "progene_text",
"text": [
"The B(max) and K(d) values of ANP receptors were evaluated from Scatchard plots ."
],
"offsets": [
[
0,
81
]
]
}
] |
[
{
"id": "split_0_train_9149_entity",
"type": "progene_text",
"text": [
"ANP receptors"
],
"offsets": [
[
30,
43
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5919
|
split_0_train_5919
|
[
{
"id": "split_0_train_5919_passage",
"type": "progene_text",
"text": [
"ANP receptor gene expression was determined by Northern blot analysis ."
],
"offsets": [
[
0,
71
]
]
}
] |
[
{
"id": "split_0_train_9150_entity",
"type": "progene_text",
"text": [
"ANP receptor"
],
"offsets": [
[
0,
12
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5920
|
split_0_train_5920
|
[
{
"id": "split_0_train_5920_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5921
|
split_0_train_5921
|
[
{
"id": "split_0_train_5921_passage",
"type": "progene_text",
"text": [
"Under basal conditions , perinatal malnutrition reduced body weight , absolute weight of kidneys and adrenals , and haematocrit ."
],
"offsets": [
[
0,
129
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5922
|
split_0_train_5922
|
[
{
"id": "split_0_train_5922_passage",
"type": "progene_text",
"text": [
"Compared with control rats , FR50 rats had significantly greater plasma VP and aldosterone levels but PRA , plasma ANP levels , plasma osmolality and hypothalamic VP gene expression were not significantly different ."
],
"offsets": [
[
0,
216
]
]
}
] |
[
{
"id": "split_0_train_9151_entity",
"type": "progene_text",
"text": [
"VP"
],
"offsets": [
[
72,
74
]
],
"normalized": []
},
{
"id": "split_0_train_9152_entity",
"type": "progene_text",
"text": [
"ANP"
],
"offsets": [
[
115,
118
]
],
"normalized": []
},
{
"id": "split_0_train_9153_entity",
"type": "progene_text",
"text": [
"VP"
],
"offsets": [
[
163,
165
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5923
|
split_0_train_5923
|
[
{
"id": "split_0_train_5923_passage",
"type": "progene_text",
"text": [
"Perinatal malnutrition did not significantly affect glomerular ANP receptor density , but in adrenals it decreased both B(max) and K(d) values of ANP-B receptors ( biological receptors ) and increased B(max) of ANP-C receptors ( clearance receptors ) ."
],
"offsets": [
[
0,
252
]
]
}
] |
[
{
"id": "split_0_train_9154_entity",
"type": "progene_text",
"text": [
"ANP receptor"
],
"offsets": [
[
63,
75
]
],
"normalized": []
},
{
"id": "split_0_train_9155_entity",
"type": "progene_text",
"text": [
"ANP-B receptors"
],
"offsets": [
[
146,
161
]
],
"normalized": []
},
{
"id": "split_0_train_9156_entity",
"type": "progene_text",
"text": [
"ANP-C receptors"
],
"offsets": [
[
211,
226
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5924
|
split_0_train_5924
|
[
{
"id": "split_0_train_5924_passage",
"type": "progene_text",
"text": [
"ANP-B(A) ( receptor subtype A of ANP-B receptors ) receptor gene expression was not significantly affected , whereas ANP-C receptor gene expression was enhanced in both adrenals and kidneys in FR50 rats ."
],
"offsets": [
[
0,
204
]
]
}
] |
[
{
"id": "split_0_train_9157_entity",
"type": "progene_text",
"text": [
"ANP-B(A) ( receptor subtype A of ANP-B receptors ) receptor"
],
"offsets": [
[
0,
59
]
],
"normalized": []
},
{
"id": "split_0_train_9158_entity",
"type": "progene_text",
"text": [
"ANP-C receptor"
],
"offsets": [
[
117,
131
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5925
|
split_0_train_5925
|
[
{
"id": "split_0_train_5925_passage",
"type": "progene_text",
"text": [
"After 72 h dehydration , control rats showed a significant rise in haematocrit , plasma osmolality , PRA , circulating levels of VP and aldosterone and VP gene expression in both PVN and SON but showed a decrease in plasma ANP levels ."
],
"offsets": [
[
0,
235
]
]
}
] |
[
{
"id": "split_0_train_9159_entity",
"type": "progene_text",
"text": [
"VP"
],
"offsets": [
[
129,
131
]
],
"normalized": []
},
{
"id": "split_0_train_9160_entity",
"type": "progene_text",
"text": [
"VP"
],
"offsets": [
[
152,
154
]
],
"normalized": []
},
{
"id": "split_0_train_9161_entity",
"type": "progene_text",
"text": [
"ANP"
],
"offsets": [
[
223,
226
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5926
|
split_0_train_5926
|
[
{
"id": "split_0_train_5926_passage",
"type": "progene_text",
"text": [
"B(max) of ANP-B receptors was decreased whereas B(max) of ANP-C receptors was enhanced in both adrenals and kidneys ."
],
"offsets": [
[
0,
117
]
]
}
] |
[
{
"id": "split_0_train_9162_entity",
"type": "progene_text",
"text": [
"ANP-B receptors"
],
"offsets": [
[
10,
25
]
],
"normalized": []
},
{
"id": "split_0_train_9163_entity",
"type": "progene_text",
"text": [
"ANP-C receptors"
],
"offsets": [
[
58,
73
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5927
|
split_0_train_5927
|
[
{
"id": "split_0_train_5927_passage",
"type": "progene_text",
"text": [
"ANP-B(A) receptor gene expression was not significantly affected in either kidneys or adrenals in dehydrated control rats ."
],
"offsets": [
[
0,
123
]
]
}
] |
[
{
"id": "split_0_train_9164_entity",
"type": "progene_text",
"text": [
"ANP-B(A) receptor"
],
"offsets": [
[
0,
17
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5928
|
split_0_train_5928
|
[
{
"id": "split_0_train_5928_passage",
"type": "progene_text",
"text": [
"Similarly , ANP-C receptor gene expression was unaffected in kidneys whereas it was significantly enhanced in adrenals ."
],
"offsets": [
[
0,
120
]
]
}
] |
[
{
"id": "split_0_train_9165_entity",
"type": "progene_text",
"text": [
"ANP-C receptor"
],
"offsets": [
[
12,
26
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5929
|
split_0_train_5929
|
[
{
"id": "split_0_train_5929_passage",
"type": "progene_text",
"text": [
"In FR50 rats , the effects of water deprivation were qualitatively similar to those reported in controls concerning plasma parameters except for plasma VP levels which tended to rise ( not significant ) but this increase was only very slight compared with controls ."
],
"offsets": [
[
0,
266
]
]
}
] |
[
{
"id": "split_0_train_9166_entity",
"type": "progene_text",
"text": [
"VP"
],
"offsets": [
[
152,
154
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5930
|
split_0_train_5930
|
[
{
"id": "split_0_train_5930_passage",
"type": "progene_text",
"text": [
"Moreover , unlike controls , VP gene expression in both PVN and SON was not enhanced after dehydration in FR50 rats ."
],
"offsets": [
[
0,
117
]
]
}
] |
[
{
"id": "split_0_train_9167_entity",
"type": "progene_text",
"text": [
"VP"
],
"offsets": [
[
29,
31
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5931
|
split_0_train_5931
|
[
{
"id": "split_0_train_5931_passage",
"type": "progene_text",
"text": [
"In kidneys , dehydrated FR50 rats , like controls , upregulated ANP-C receptors , but they were unable to downregulate ANP-B receptors ."
],
"offsets": [
[
0,
136
]
]
}
] |
[
{
"id": "split_0_train_9168_entity",
"type": "progene_text",
"text": [
"ANP-C receptors"
],
"offsets": [
[
64,
79
]
],
"normalized": []
},
{
"id": "split_0_train_9169_entity",
"type": "progene_text",
"text": [
"ANP-B receptors"
],
"offsets": [
[
119,
134
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5932
|
split_0_train_5932
|
[
{
"id": "split_0_train_5932_passage",
"type": "progene_text",
"text": [
"In adrenals , unlike controls , FR50 rats enhanced ANP-B receptor density whereas they decreased both ANP-C receptor density and expression after 72 h dehydration ."
],
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0,
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}
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"ANP-C receptor"
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102,
116
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}
] |
[] |
[] |
[] |
split_0_train_5933
|
split_0_train_5933
|
[
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"id": "split_0_train_5933_passage",
"type": "progene_text",
"text": [
"Similar to controls , the expression of ANP-B(A) receptors in both kidneys and adrenals as well as the expression of ANP-C receptors in kidneys , were unaffected in dehydrated FR50 rats ."
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0,
187
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}
] |
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"text": [
"ANP-C receptors"
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[
117,
132
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],
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}
] |
[] |
[] |
[] |
split_0_train_5934
|
split_0_train_5934
|
[
{
"id": "split_0_train_5934_passage",
"type": "progene_text",
"text": [
"CONCLUSION :"
],
"offsets": [
[
0,
12
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5935
|
split_0_train_5935
|
[
{
"id": "split_0_train_5935_passage",
"type": "progene_text",
"text": [
"Perinatal malnutrition had long - lasting effects on regulation of the fluid and electrolyte balance under basal conditions ."
],
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[
0,
125
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5936
|
split_0_train_5936
|
[
{
"id": "split_0_train_5936_passage",
"type": "progene_text",
"text": [
"The main effects were a significant rise in circulating levels of VP and aldosterone , and changes in density of adrenal ANP - binding sites and ANP-C receptor gene expression in both adrenals and kidneys ."
],
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0,
206
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}
] |
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"text": [
"ANP-C receptor"
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145,
159
]
],
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}
] |
[] |
[] |
[] |
split_0_train_5937
|
split_0_train_5937
|
[
{
"id": "split_0_train_5937_passage",
"type": "progene_text",
"text": [
"Perinatal malnutrition also affects the responsiveness to water deprivation with alterations in both hypothalamic VP gene expression and regulation of ANP - binding sites ."
],
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[
0,
172
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]
}
] |
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{
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114,
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"text": [
"ANP"
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151,
154
]
],
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}
] |
[] |
[] |
[] |
split_0_train_5938
|
split_0_train_5938
|
[
{
"id": "split_0_train_5938_passage",
"type": "progene_text",
"text": [
"Evidence for a role of p38 kinase in hypoxia - inducible factor 1 - independent induction of vascular endothelial growth factor expression by sodium arsenite ."
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0,
159
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]
}
] |
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{
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23,
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"text": [
"vascular endothelial growth factor"
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[
93,
127
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],
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}
] |
[] |
[] |
[] |
split_0_train_5939
|
split_0_train_5939
|
[
{
"id": "split_0_train_5939_passage",
"type": "progene_text",
"text": [
"Recently we have demonstrated that sodium arsenite induces the expression of hypoxia - inducible factor 1alpha ( HIF-1alpha ) protein and vascular endothelial growth factor ( VEGF ) in OVCAR-3 human ovarian cancer cells ."
],
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[
0,
221
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]
}
] |
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{
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113,
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"text": [
"VEGF"
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[
175,
179
]
],
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}
] |
[] |
[] |
[] |
split_0_train_5940
|
split_0_train_5940
|
[
{
"id": "split_0_train_5940_passage",
"type": "progene_text",
"text": [
"We now show that arsenic trioxide , an experimental anticancer drug , exerts the same effects ."
],
"offsets": [
[
0,
95
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5941
|
split_0_train_5941
|
[
{
"id": "split_0_train_5941_passage",
"type": "progene_text",
"text": [
"The involvement of phosphatidylinositol 3-kinase and mitogen - activated protein kinase ( MAPK ) pathways in the effects of sodium arsenite was investigated ."
],
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[
0,
158
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]
}
] |
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{
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19,
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"type": "progene_text",
"text": [
"MAPK"
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[
90,
94
]
],
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}
] |
[] |
[] |
[] |
split_0_train_5942
|
split_0_train_5942
|
[
{
"id": "split_0_train_5942_passage",
"type": "progene_text",
"text": [
"By using kinase inhibitors in OVCAR-3 cells , both effects of sodium arsenite were found to be independent of phosphatidylinositol 3-kinase and p44 / p42 MAPKS but were attenuated by inhibition of p38 MAPK ."
],
"offsets": [
[
0,
207
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]
}
] |
[
{
"id": "split_0_train_9189_entity",
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110,
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{
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144,
159
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{
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"type": "progene_text",
"text": [
"p38 MAPK"
],
"offsets": [
[
197,
205
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5943
|
split_0_train_5943
|
[
{
"id": "split_0_train_5943_passage",
"type": "progene_text",
"text": [
"A role for p38 in the regulation of HIF-1alpha and VEGF expression was supported further by analysis of activation kinetics ."
],
"offsets": [
[
0,
125
]
]
}
] |
[
{
"id": "split_0_train_9192_entity",
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"text": [
"p38"
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11,
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{
"id": "split_0_train_9193_entity",
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36,
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{
"id": "split_0_train_9194_entity",
"type": "progene_text",
"text": [
"VEGF"
],
"offsets": [
[
51,
55
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5944
|
split_0_train_5944
|
[
{
"id": "split_0_train_5944_passage",
"type": "progene_text",
"text": [
"Experiments in mouse fibroblast cell lines , lacking expression of c-Jun N - terminal kinases 1 and 2 , suggested that these kinases are not required for induction of HIF-1alpha protein and VEGF mRNA ."
],
"offsets": [
[
0,
201
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]
}
] |
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{
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125,
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{
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"type": "progene_text",
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167,
177
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"type": "progene_text",
"text": [
"VEGF"
],
"offsets": [
[
190,
194
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5945
|
split_0_train_5945
|
[
{
"id": "split_0_train_5945_passage",
"type": "progene_text",
"text": [
"Unexpectedly , sodium arsenite did not activate a HIF-1 - dependent reporter gene in OVCAR-3 cells , indicating that functional HIF-1 was not induced ."
],
"offsets": [
[
0,
151
]
]
}
] |
[
{
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"type": "progene_text",
"text": [
"HIF-1"
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50,
55
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{
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"type": "progene_text",
"text": [
"HIF-1"
],
"offsets": [
[
128,
133
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5946
|
split_0_train_5946
|
[
{
"id": "split_0_train_5946_passage",
"type": "progene_text",
"text": [
"In agreement with this hypothesis , up - regulation of VEGF mRNA was not reduced in HIF-1alpha ( -/- ) mouse fibroblast cell lines ."
],
"offsets": [
[
0,
132
]
]
}
] |
[
{
"id": "split_0_train_9201_entity",
"type": "progene_text",
"text": [
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"text": [
"HIF-1alpha"
],
"offsets": [
[
84,
94
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5947
|
split_0_train_5947
|
[
{
"id": "split_0_train_5947_passage",
"type": "progene_text",
"text": [
"Altogether , these data suggest that not HIF-1 , but rather p38 , mediates induction of VEGF mRNA expression by sodium arsenite ."
],
"offsets": [
[
0,
129
]
]
}
] |
[
{
"id": "split_0_train_9203_entity",
"type": "progene_text",
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41,
46
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{
"id": "split_0_train_9204_entity",
"type": "progene_text",
"text": [
"p38"
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60,
63
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},
{
"id": "split_0_train_9205_entity",
"type": "progene_text",
"text": [
"VEGF"
],
"offsets": [
[
88,
92
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5948
|
split_0_train_5948
|
[
{
"id": "split_0_train_5948_passage",
"type": "progene_text",
"text": [
"Interaction of alphaPIX ( ARHGEF6 ) with beta-parvin ( PARVB ) suggests an involvement of alphaPIX in integrin - mediated signaling ."
],
"offsets": [
[
0,
133
]
]
}
] |
[
{
"id": "split_0_train_9206_entity",
"type": "progene_text",
"text": [
"alphaPIX"
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15,
23
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},
{
"id": "split_0_train_9207_entity",
"type": "progene_text",
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26,
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"type": "progene_text",
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41,
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{
"id": "split_0_train_9209_entity",
"type": "progene_text",
"text": [
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55,
60
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},
{
"id": "split_0_train_9210_entity",
"type": "progene_text",
"text": [
"alphaPIX"
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90,
98
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{
"id": "split_0_train_9211_entity",
"type": "progene_text",
"text": [
"integrin"
],
"offsets": [
[
102,
110
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5949
|
split_0_train_5949
|
[
{
"id": "split_0_train_5949_passage",
"type": "progene_text",
"text": [
"Members of the Rho GTPase family are key regulatory molecules that link surface receptors to the organization of the actin cytoskeleton ."
],
"offsets": [
[
0,
137
]
]
}
] |
[
{
"id": "split_0_train_9212_entity",
"type": "progene_text",
"text": [
"Rho GTPase family"
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"offsets": [
[
15,
32
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"normalized": []
},
{
"id": "split_0_train_9213_entity",
"type": "progene_text",
"text": [
"actin"
],
"offsets": [
[
117,
122
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5950
|
split_0_train_5950
|
[
{
"id": "split_0_train_5950_passage",
"type": "progene_text",
"text": [
"It is now well established that these small GTPases are also crucial for neuronal morphogenesis and connectivity ."
],
"offsets": [
[
0,
114
]
]
}
] |
[
{
"id": "split_0_train_9214_entity",
"type": "progene_text",
"text": [
"small GTPases"
],
"offsets": [
[
38,
51
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5951
|
split_0_train_5951
|
[
{
"id": "split_0_train_5951_passage",
"type": "progene_text",
"text": [
"Moreover , mutations in ARHGEF6 ( also known as alphaPIX or Cool-2 ) , encoding a Rac1 / Cdc42 - specific guanine nucleotide exchange factor , have been implicated in X - linked mental retardation ."
],
"offsets": [
[
0,
198
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]
}
] |
[
{
"id": "split_0_train_9215_entity",
"type": "progene_text",
"text": [
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24,
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{
"id": "split_0_train_9216_entity",
"type": "progene_text",
"text": [
"alphaPIX"
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[
48,
56
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],
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},
{
"id": "split_0_train_9217_entity",
"type": "progene_text",
"text": [
"Cool-2"
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"offsets": [
[
60,
66
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],
"normalized": []
},
{
"id": "split_0_train_9218_entity",
"type": "progene_text",
"text": [
"Rac1"
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[
82,
86
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"normalized": []
},
{
"id": "split_0_train_9219_entity",
"type": "progene_text",
"text": [
"Cdc42"
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"offsets": [
[
89,
94
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],
"normalized": []
},
{
"id": "split_0_train_9220_entity",
"type": "progene_text",
"text": [
"guanine nucleotide exchange factor"
],
"offsets": [
[
106,
140
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5952
|
split_0_train_5952
|
[
{
"id": "split_0_train_5952_passage",
"type": "progene_text",
"text": [
"In an attempt to get insight into the biological function of ARHGEF6 and the upstream signaling cascades leading to its activation , we used the full - length coding region of ARHGEF6 as bait in yeast - two hybrid screens and identified PARVB ( beta-parvin or affixin ) as a novel binding partner ."
],
"offsets": [
[
0,
298
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]
}
] |
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{
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"type": "progene_text",
"text": [
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[
61,
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{
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"text": [
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176,
183
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},
{
"id": "split_0_train_9223_entity",
"type": "progene_text",
"text": [
"PARVB"
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[
237,
242
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"normalized": []
},
{
"id": "split_0_train_9224_entity",
"type": "progene_text",
"text": [
"beta-parvin"
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"offsets": [
[
245,
256
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],
"normalized": []
},
{
"id": "split_0_train_9225_entity",
"type": "progene_text",
"text": [
"affixin"
],
"offsets": [
[
260,
267
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5953
|
split_0_train_5953
|
[
{
"id": "split_0_train_5953_passage",
"type": "progene_text",
"text": [
"The interaction was confirmed by co - immunoprecipitation and GST pull - down ."
],
"offsets": [
[
0,
79
]
]
}
] |
[
{
"id": "split_0_train_9226_entity",
"type": "progene_text",
"text": [
"GST"
],
"offsets": [
[
62,
65
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5954
|
split_0_train_5954
|
[
{
"id": "split_0_train_5954_passage",
"type": "progene_text",
"text": [
"We showed by immunofluorescence that ARHGEF6 and PARVB co - localize at the cell periphery to lamellipodia and ruffles in well - spread and actively spreading cells adhered to fibronectin ."
],
"offsets": [
[
0,
189
]
]
}
] |
[
{
"id": "split_0_train_9227_entity",
"type": "progene_text",
"text": [
"ARHGEF6"
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"offsets": [
[
37,
44
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{
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[] |
[] |
split_0_train_5955
|
split_0_train_5955
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[] |
[] |
split_0_train_5956
|
split_0_train_5956
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210,
215
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}
] |
[] |
[] |
[] |
split_0_train_5957
|
split_0_train_5957
|
[
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102,
109
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}
] |
[] |
[] |
[] |
split_0_train_5958
|
split_0_train_5958
|
[
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"text": [
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142,
147
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}
] |
[] |
[] |
[] |
split_0_train_5959
|
split_0_train_5959
|
[
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0,
137
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128,
135
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}
] |
[] |
[] |
[] |
split_0_train_5960
|
split_0_train_5960
|
[
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151
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"text": [
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140,
149
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}
] |
[] |
[] |
[] |
split_0_train_5961
|
split_0_train_5961
|
[
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"type": "progene_text",
"text": [
"The identification of PARVB as an ARHGEF6 interacting partner together with the co - localization of ARHGEF6 and ILK in spreading cells suggest that ARHGEF6 is involved in integrin - mediated signaling leading to activation of the GTPases Rac1 and/or Cdc42 ."
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"text": [
"Cdc42"
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[
251,
256
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5962
|
split_0_train_5962
|
[
{
"id": "split_0_train_5962_passage",
"type": "progene_text",
"text": [
"Concentrations of apolipoproteins E , C2 , and C3 and lipid profile in preeclampsia ."
],
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[
0,
85
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]
}
] |
[
{
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"text": [
"apolipoproteins E , C2 , and C3"
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[
18,
49
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],
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}
] |
[] |
[] |
[] |
split_0_train_5963
|
split_0_train_5963
|
[
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"id": "split_0_train_5963_passage",
"type": "progene_text",
"text": [
"OBJECTIVE :"
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"offsets": [
[
0,
11
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5964
|
split_0_train_5964
|
[
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"id": "split_0_train_5964_passage",
"type": "progene_text",
"text": [
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0,
102
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}
] |
[
{
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"text": [
"Apo E"
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"offsets": [
[
86,
91
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5965
|
split_0_train_5965
|
[
{
"id": "split_0_train_5965_passage",
"type": "progene_text",
"text": [
"Apo E may favor lipid uptake by macrophages and is thought to increase triglycerides clearance ."
],
"offsets": [
[
0,
96
]
]
}
] |
[
{
"id": "split_0_train_9264_entity",
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"text": [
"Apo E"
],
"offsets": [
[
0,
5
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5966
|
split_0_train_5966
|
[
{
"id": "split_0_train_5966_passage",
"type": "progene_text",
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],
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0,
150
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]
}
] |
[
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15,
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102,
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"text": [
"Apo C2"
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"offsets": [
[
140,
146
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5967
|
split_0_train_5967
|
[
{
"id": "split_0_train_5967_passage",
"type": "progene_text",
"text": [
"LPL activity may also be impaired by high levels of the LPL inhibitor apolipoprotein C3 ( Apo C3 ) ."
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[
0,
100
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]
}
] |
[
{
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"text": [
"Apo C3"
],
"offsets": [
[
90,
96
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5968
|
split_0_train_5968
|
[
{
"id": "split_0_train_5968_passage",
"type": "progene_text",
"text": [
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],
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[
0,
133
]
]
}
] |
[
{
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81,
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92,
98
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{
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"type": "progene_text",
"text": [
"Apo E"
],
"offsets": [
[
126,
131
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5969
|
split_0_train_5969
|
[
{
"id": "split_0_train_5969_passage",
"type": "progene_text",
"text": [
"We investigated the involvement of these three lipoproteins in lipid disorders associated with preeclampsia ."
],
"offsets": [
[
0,
109
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5970
|
split_0_train_5970
|
[
{
"id": "split_0_train_5970_passage",
"type": "progene_text",
"text": [
"METHODS :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5971
|
split_0_train_5971
|
[
{
"id": "split_0_train_5971_passage",
"type": "progene_text",
"text": [
"Blood samples were taken from 25 normotensive and 24 preeclamptic pregnant women after a 12 - hr fasting period ."
],
"offsets": [
[
0,
113
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5972
|
split_0_train_5972
|
[
{
"id": "split_0_train_5972_passage",
"type": "progene_text",
"text": [
"These samples were analyzed for standard lipid profile and Apo E , C2 , C3 concentrations ."
],
"offsets": [
[
0,
91
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]
}
] |
[
{
"id": "split_0_train_9277_entity",
"type": "progene_text",
"text": [
"Apo E , C2 , C3"
],
"offsets": [
[
59,
74
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5973
|
split_0_train_5973
|
[
{
"id": "split_0_train_5973_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5974
|
split_0_train_5974
|
[
{
"id": "split_0_train_5974_passage",
"type": "progene_text",
"text": [
"Concentrations of triglycerides , total cholesterol , LDL , HDL , and LDL cholesterol did not differ significantly between preeclamptic women and pregnant controls ."
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[
0,
165
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]
}
] |
[
{
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54,
57
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{
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60,
63
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{
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"type": "progene_text",
"text": [
"LDL"
],
"offsets": [
[
70,
73
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5975
|
split_0_train_5975
|
[
{
"id": "split_0_train_5975_passage",
"type": "progene_text",
"text": [
"Apo C2 concentration and Apo E / Apo C2 ratio did not differ between the two groups of women but Apo C3 and Apo E concentrations were higher in preeclamptic than in pregnant controls ."
],
"offsets": [
[
0,
184
]
]
}
] |
[
{
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0,
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{
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30
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{
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33,
39
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{
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"text": [
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97,
103
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{
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"type": "progene_text",
"text": [
"Apo E"
],
"offsets": [
[
108,
113
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5976
|
split_0_train_5976
|
[
{
"id": "split_0_train_5976_passage",
"type": "progene_text",
"text": [
"The ratio of triglycerides to Apo E was similar in the two groups of women ."
],
"offsets": [
[
0,
76
]
]
}
] |
[
{
"id": "split_0_train_9286_entity",
"type": "progene_text",
"text": [
"Apo E"
],
"offsets": [
[
30,
35
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5977
|
split_0_train_5977
|
[
{
"id": "split_0_train_5977_passage",
"type": "progene_text",
"text": [
"In both groups , triglycerides levels were positively correlated with Apo E ( p = 0.0429 ) , Apo C2 ( p = 0.0045 ) and Apo C3 ( p = 0.0004 ) concentrations , but not with Apo E / Apo C2 ratio ( p = 0.760 ) ."
],
"offsets": [
[
0,
207
]
]
}
] |
[
{
"id": "split_0_train_9287_entity",
"type": "progene_text",
"text": [
"Apo E"
],
"offsets": [
[
70,
75
]
],
"normalized": []
},
{
"id": "split_0_train_9288_entity",
"type": "progene_text",
"text": [
"Apo C2"
],
"offsets": [
[
93,
99
]
],
"normalized": []
},
{
"id": "split_0_train_9289_entity",
"type": "progene_text",
"text": [
"Apo C3"
],
"offsets": [
[
119,
125
]
],
"normalized": []
},
{
"id": "split_0_train_9290_entity",
"type": "progene_text",
"text": [
"Apo E"
],
"offsets": [
[
171,
176
]
],
"normalized": []
},
{
"id": "split_0_train_9291_entity",
"type": "progene_text",
"text": [
"Apo C2"
],
"offsets": [
[
179,
185
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5978
|
split_0_train_5978
|
[
{
"id": "split_0_train_5978_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5979
|
split_0_train_5979
|
[
{
"id": "split_0_train_5979_passage",
"type": "progene_text",
"text": [
"In preeclamptic women , the increase in Apo E concentration may not increase triglycerides clearance because LPL activity seems to be inhibited by high Apo C3 concentration ."
],
"offsets": [
[
0,
174
]
]
}
] |
[
{
"id": "split_0_train_9292_entity",
"type": "progene_text",
"text": [
"Apo E"
],
"offsets": [
[
40,
45
]
],
"normalized": []
},
{
"id": "split_0_train_9293_entity",
"type": "progene_text",
"text": [
"LPL"
],
"offsets": [
[
109,
112
]
],
"normalized": []
},
{
"id": "split_0_train_9294_entity",
"type": "progene_text",
"text": [
"Apo C3"
],
"offsets": [
[
152,
158
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5980
|
split_0_train_5980
|
[
{
"id": "split_0_train_5980_passage",
"type": "progene_text",
"text": [
"Traffic at the tmRNA gene ."
],
"offsets": [
[
0,
27
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5981
|
split_0_train_5981
|
[
{
"id": "split_0_train_5981_passage",
"type": "progene_text",
"text": [
"A partial screen for genetic elements integrated into completely sequenced bacterial genomes shows more significant bias in specificity for the tmRNA gene ( ssrA ) than for any type of tRNA gene ."
],
"offsets": [
[
0,
196
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5982
|
split_0_train_5982
|
[
{
"id": "split_0_train_5982_passage",
"type": "progene_text",
"text": [
"Horizontal gene transfer , a major avenue of bacterial evolution , was assessed by focusing on elements using this single attachment locus ."
],
"offsets": [
[
0,
140
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5983
|
split_0_train_5983
|
[
{
"id": "split_0_train_5983_passage",
"type": "progene_text",
"text": [
"Diverse elements use ssrA ; among enterobacteria alone , at least four different integrase subfamilies have independently evolved specificity for ssrA , and almost every strain analyzed presents a unique set of integrated elements ."
],
"offsets": [
[
0,
232
]
]
}
] |
[
{
"id": "split_0_train_9295_entity",
"type": "progene_text",
"text": [
"integrase"
],
"offsets": [
[
81,
90
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5984
|
split_0_train_5984
|
[
{
"id": "split_0_train_5984_passage",
"type": "progene_text",
"text": [
"Even elements using essentially the same integrase can be very diverse , as is a group with an ssrA - specific integrase of the P4 subfamily ."
],
"offsets": [
[
0,
142
]
]
}
] |
[
{
"id": "split_0_train_9296_entity",
"type": "progene_text",
"text": [
"integrase"
],
"offsets": [
[
41,
50
]
],
"normalized": []
},
{
"id": "split_0_train_9297_entity",
"type": "progene_text",
"text": [
"integrase"
],
"offsets": [
[
111,
120
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5985
|
split_0_train_5985
|
[
{
"id": "split_0_train_5985_passage",
"type": "progene_text",
"text": [
"This same integrase appears to promote damage routinely at attachment sites , which may be adaptive ."
],
"offsets": [
[
0,
101
]
]
}
] |
[
{
"id": "split_0_train_9298_entity",
"type": "progene_text",
"text": [
"integrase"
],
"offsets": [
[
10,
19
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5986
|
split_0_train_5986
|
[
{
"id": "split_0_train_5986_passage",
"type": "progene_text",
"text": [
"Elements in arrays can recombine ; one such event mediated by invertible DNA segments within neighboring elements likely explains the monophasic nature of Salmonella enterica serovar Typhi ."
],
"offsets": [
[
0,
190
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5987
|
split_0_train_5987
|
[
{
"id": "split_0_train_5987_passage",
"type": "progene_text",
"text": [
"One of a limited set of conserved sequences occurs at the attachment site of each enterobacterial element , apparently serving as a transcriptional terminator for ssrA ."
],
"offsets": [
[
0,
169
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5988
|
split_0_train_5988
|
[
{
"id": "split_0_train_5988_passage",
"type": "progene_text",
"text": [
"Elements were usually found integrated into tRNA - like sequence at the 3' end of ssrA , at subsites corresponding to those used in tRNA genes ; an exception was found at the non - tRNA - like 3' end produced by ssrA gene permutation in cyanobacteria , suggesting that , during the evolution of new site specificity by integrases , tropism toward a conserved 3' end of an RNA gene may be as strong as toward a tRNA - like sequence ."
],
"offsets": [
[
0,
432
]
]
}
] |
[
{
"id": "split_0_train_9299_entity",
"type": "progene_text",
"text": [
"integrases"
],
"offsets": [
[
319,
329
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5989
|
split_0_train_5989
|
[
{
"id": "split_0_train_5989_passage",
"type": "progene_text",
"text": [
"The proximity of ssrA and smpB , which act in concert , was also surveyed ."
],
"offsets": [
[
0,
75
]
]
}
] |
[
{
"id": "split_0_train_9300_entity",
"type": "progene_text",
"text": [
"smpB"
],
"offsets": [
[
26,
30
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5990
|
split_0_train_5990
|
[
{
"id": "split_0_train_5990_passage",
"type": "progene_text",
"text": [
"Enhanced 11beta-hydroxysteroid dehydrogenase type 1 activity in stress adaptation in the guinea pig ."
],
"offsets": [
[
0,
101
]
]
}
] |
[
{
"id": "split_0_train_9301_entity",
"type": "progene_text",
"text": [
"11beta-hydroxysteroid dehydrogenase type 1"
],
"offsets": [
[
9,
51
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5991
|
split_0_train_5991
|
[
{
"id": "split_0_train_5991_passage",
"type": "progene_text",
"text": [
"The 11beta-hydroxysteroid dehydrogenases ( 11beta-HSDs ) convert cortisol to its inactive metabolite cortisone and vice versa ."
],
"offsets": [
[
0,
127
]
]
}
] |
[
{
"id": "split_0_train_9302_entity",
"type": "progene_text",
"text": [
"11beta-hydroxysteroid dehydrogenases"
],
"offsets": [
[
4,
40
]
],
"normalized": []
},
{
"id": "split_0_train_9303_entity",
"type": "progene_text",
"text": [
"11beta-HSDs"
],
"offsets": [
[
43,
54
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5992
|
split_0_train_5992
|
[
{
"id": "split_0_train_5992_passage",
"type": "progene_text",
"text": [
"11beta-HSD type 1 ( 11beta-HSD-1 ) functions as a reductase in vivo , regulating intracellular cortisol levels and its access to the glucocorticoid receptor ."
],
"offsets": [
[
0,
158
]
]
}
] |
[
{
"id": "split_0_train_9304_entity",
"type": "progene_text",
"text": [
"11beta-HSD type 1"
],
"offsets": [
[
0,
17
]
],
"normalized": []
},
{
"id": "split_0_train_9305_entity",
"type": "progene_text",
"text": [
"11beta-HSD-1"
],
"offsets": [
[
20,
32
]
],
"normalized": []
},
{
"id": "split_0_train_9306_entity",
"type": "progene_text",
"text": [
"reductase"
],
"offsets": [
[
50,
59
]
],
"normalized": []
},
{
"id": "split_0_train_9307_entity",
"type": "progene_text",
"text": [
"glucocorticoid receptor"
],
"offsets": [
[
133,
156
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5993
|
split_0_train_5993
|
[
{
"id": "split_0_train_5993_passage",
"type": "progene_text",
"text": [
"In contrast , 11beta-HSD-2 only mediates oxidation of natural glucocorticoids , and protects the mineralocorticoid receptor from high cortisol concentrations ."
],
"offsets": [
[
0,
159
]
]
}
] |
[
{
"id": "split_0_train_9308_entity",
"type": "progene_text",
"text": [
"11beta-HSD-2"
],
"offsets": [
[
14,
26
]
],
"normalized": []
},
{
"id": "split_0_train_9309_entity",
"type": "progene_text",
"text": [
"mineralocorticoid receptor"
],
"offsets": [
[
97,
123
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5994
|
split_0_train_5994
|
[
{
"id": "split_0_train_5994_passage",
"type": "progene_text",
"text": [
"We investigated the in vivo and in vitro effects of ACTH on the recently characterized 11beta-HSDs in guinea pig liver and kidney ."
],
"offsets": [
[
0,
131
]
]
}
] |
[
{
"id": "split_0_train_9310_entity",
"type": "progene_text",
"text": [
"ACTH"
],
"offsets": [
[
52,
56
]
],
"normalized": []
},
{
"id": "split_0_train_9311_entity",
"type": "progene_text",
"text": [
"11beta-HSDs"
],
"offsets": [
[
87,
98
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5995
|
split_0_train_5995
|
[
{
"id": "split_0_train_5995_passage",
"type": "progene_text",
"text": [
"Tissue slices of untreated guinea pigs were incubated with (3)H-labelled cortisol or cortisone and ACTH(1-24) ( 10(-10) and 10(-9) mol / l ) ."
],
"offsets": [
[
0,
142
]
]
}
] |
[
{
"id": "split_0_train_9312_entity",
"type": "progene_text",
"text": [
"ACTH(1-24)"
],
"offsets": [
[
99,
109
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5996
|
split_0_train_5996
|
[
{
"id": "split_0_train_5996_passage",
"type": "progene_text",
"text": [
"The 11beta-HSD activities in liver and kidney slices were not influenced by in vitro incubation with ACTH(1-24) ."
],
"offsets": [
[
0,
113
]
]
}
] |
[
{
"id": "split_0_train_9313_entity",
"type": "progene_text",
"text": [
"11beta-HSD"
],
"offsets": [
[
4,
14
]
],
"normalized": []
},
{
"id": "split_0_train_9314_entity",
"type": "progene_text",
"text": [
"ACTH(1-24)"
],
"offsets": [
[
101,
111
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5997
|
split_0_train_5997
|
[
{
"id": "split_0_train_5997_passage",
"type": "progene_text",
"text": [
"In addition , guinea pigs were treated with ACTH(1-24 ) or saline injections s.c. for 3 days ."
],
"offsets": [
[
0,
94
]
]
}
] |
[
{
"id": "split_0_train_9315_entity",
"type": "progene_text",
"text": [
"ACTH(1-24"
],
"offsets": [
[
44,
53
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_5998
|
split_0_train_5998
|
[
{
"id": "split_0_train_5998_passage",
"type": "progene_text",
"text": [
"Liver and kidney tissue slices of these animals were incubated with (3)H-labelled cortisol or cortisone ."
],
"offsets": [
[
0,
105
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_5999
|
split_0_train_5999
|
[
{
"id": "split_0_train_5999_passage",
"type": "progene_text",
"text": [
"In vivo ACTH treatment significantly increased reductase and decreased oxidase activity in liver and kidney ."
],
"offsets": [
[
0,
109
]
]
}
] |
[
{
"id": "split_0_train_9316_entity",
"type": "progene_text",
"text": [
"ACTH"
],
"offsets": [
[
8,
12
]
],
"normalized": []
},
{
"id": "split_0_train_9317_entity",
"type": "progene_text",
"text": [
"reductase"
],
"offsets": [
[
47,
56
]
],
"normalized": []
},
{
"id": "split_0_train_9318_entity",
"type": "progene_text",
"text": [
"oxidase"
],
"offsets": [
[
71,
78
]
],
"normalized": []
}
] |
[] |
[] |
[] |
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