id
stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
split_0_train_6000
|
split_0_train_6000
|
[
{
"id": "split_0_train_6000_passage",
"type": "progene_text",
"text": [
"Furthermore , 11beta-HSD-1 activity assessed by measurement of the urinary ratio of ( tetrahydrocortisol ( THF ) + 5alphaTHF ) / ( tetrahydrocortisone ) was significantly increased after ACTH treatment compared with the control group ."
],
"offsets": [
[
0,
235
]
]
}
] |
[
{
"id": "split_0_train_9319_entity",
"type": "progene_text",
"text": [
"11beta-HSD-1"
],
"offsets": [
[
14,
26
]
],
"normalized": []
},
{
"id": "split_0_train_9320_entity",
"type": "progene_text",
"text": [
"ACTH"
],
"offsets": [
[
187,
191
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6001
|
split_0_train_6001
|
[
{
"id": "split_0_train_6001_passage",
"type": "progene_text",
"text": [
"Plasma levels of cortisol , cortisone , progesterone , 17-hydroxyprogesterone and androstenedione increased significantly following in vivo ACTH treatment ."
],
"offsets": [
[
0,
156
]
]
}
] |
[
{
"id": "split_0_train_9321_entity",
"type": "progene_text",
"text": [
"ACTH"
],
"offsets": [
[
140,
144
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6002
|
split_0_train_6002
|
[
{
"id": "split_0_train_6002_passage",
"type": "progene_text",
"text": [
"The enhanced reductase activity of the hepatic and renal 11beta-HSD-1 is apparently caused by cortisol or other ACTH - dependent steroids rather than by ACTH itself ."
],
"offsets": [
[
0,
166
]
]
}
] |
[
{
"id": "split_0_train_9322_entity",
"type": "progene_text",
"text": [
"reductase"
],
"offsets": [
[
13,
22
]
],
"normalized": []
},
{
"id": "split_0_train_9323_entity",
"type": "progene_text",
"text": [
"11beta-HSD-1"
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"offsets": [
[
57,
69
]
],
"normalized": []
},
{
"id": "split_0_train_9324_entity",
"type": "progene_text",
"text": [
"ACTH"
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"offsets": [
[
112,
116
]
],
"normalized": []
},
{
"id": "split_0_train_9325_entity",
"type": "progene_text",
"text": [
"ACTH"
],
"offsets": [
[
153,
157
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6003
|
split_0_train_6003
|
[
{
"id": "split_0_train_6003_passage",
"type": "progene_text",
"text": [
"This may be an important fine regulation of the glucocorticoid tonus for stress adaptation in every organ , e.g. enhanced gluconeogenesis in liver ."
],
"offsets": [
[
0,
148
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6004
|
split_0_train_6004
|
[
{
"id": "split_0_train_6004_passage",
"type": "progene_text",
"text": [
"Cloning and sequence analysis of a mitochondrial gene cluster encoding cytochrome C oxidase subunit III from Trichoderma pseudokoningii ."
],
"offsets": [
[
0,
137
]
]
}
] |
[
{
"id": "split_0_train_9326_entity",
"type": "progene_text",
"text": [
"cytochrome C oxidase subunit III"
],
"offsets": [
[
71,
103
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6005
|
split_0_train_6005
|
[
{
"id": "split_0_train_6005_passage",
"type": "progene_text",
"text": [
"A mitochondrial gene cluster encoding cytochrome c oxidase subunit III ( COX3 ) , an ORF ( called ORF250 ) similar to NADH dehydrogenase subunit VI ( ND6 ) , ten tRNA molecules , partial rRNA small subunit and rRNA large subunit from Trichoderma pseudokoningii S38 was cloned and sequenced ."
],
"offsets": [
[
0,
291
]
]
}
] |
[
{
"id": "split_0_train_9327_entity",
"type": "progene_text",
"text": [
"cytochrome c oxidase subunit III"
],
"offsets": [
[
38,
70
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],
"normalized": []
},
{
"id": "split_0_train_9328_entity",
"type": "progene_text",
"text": [
"COX3"
],
"offsets": [
[
73,
77
]
],
"normalized": []
},
{
"id": "split_0_train_9329_entity",
"type": "progene_text",
"text": [
"NADH dehydrogenase subunit VI"
],
"offsets": [
[
118,
147
]
],
"normalized": []
},
{
"id": "split_0_train_9330_entity",
"type": "progene_text",
"text": [
"ND6"
],
"offsets": [
[
150,
153
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6006
|
split_0_train_6006
|
[
{
"id": "split_0_train_6006_passage",
"type": "progene_text",
"text": [
"These genes are tandemly clustered on the mitochondrial genome of Trichoderma pseudokoningii S38 ."
],
"offsets": [
[
0,
98
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6007
|
split_0_train_6007
|
[
{
"id": "split_0_train_6007_passage",
"type": "progene_text",
"text": [
"Phylogenetic analysis showed that cytochrome C oxidase subunits III exhibited high degree of similarity to sequences from Hypocrea jecorina , Verticillium lecanii , Podospora anserine , Neurospora crassa and Magnaporthe grisea ( 99 , 90 , 84 , 82 and 79 % identity , respectively ) ."
],
"offsets": [
[
0,
283
]
]
}
] |
[
{
"id": "split_0_train_9331_entity",
"type": "progene_text",
"text": [
"cytochrome C oxidase subunits III"
],
"offsets": [
[
34,
67
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6008
|
split_0_train_6008
|
[
{
"id": "split_0_train_6008_passage",
"type": "progene_text",
"text": [
"Prediction of transmembrane helices revealed that COX3 was a transmembrane protein ."
],
"offsets": [
[
0,
84
]
]
}
] |
[
{
"id": "split_0_train_9332_entity",
"type": "progene_text",
"text": [
"COX3"
],
"offsets": [
[
50,
54
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6009
|
split_0_train_6009
|
[
{
"id": "split_0_train_6009_passage",
"type": "progene_text",
"text": [
"Northern dot blot analysis showed that the cytochrome c oxidase subunits III gene we had cloned is actively transcribed in the T. pseudokoningii mitochondria ."
],
"offsets": [
[
0,
159
]
]
}
] |
[
{
"id": "split_0_train_9333_entity",
"type": "progene_text",
"text": [
"cytochrome c oxidase subunits III"
],
"offsets": [
[
43,
76
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6010
|
split_0_train_6010
|
[
{
"id": "split_0_train_6010_passage",
"type": "progene_text",
"text": [
"The L1 major capsid protein of human papillomavirus type 11 interacts with Kap beta2 and Kap beta3 nuclear import receptors ."
],
"offsets": [
[
0,
125
]
]
}
] |
[
{
"id": "split_0_train_9334_entity",
"type": "progene_text",
"text": [
"L1 major capsid protein"
],
"offsets": [
[
4,
27
]
],
"normalized": []
},
{
"id": "split_0_train_9335_entity",
"type": "progene_text",
"text": [
"Kap beta2"
],
"offsets": [
[
75,
84
]
],
"normalized": []
},
{
"id": "split_0_train_9336_entity",
"type": "progene_text",
"text": [
"Kap beta3"
],
"offsets": [
[
89,
98
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6011
|
split_0_train_6011
|
[
{
"id": "split_0_train_6011_passage",
"type": "progene_text",
"text": [
"We have previously shown that the L1 major capsid protein of low - risk HPV11 binds to the Kap alpha2 adapter and enters the nucleus via a Kap alpha2beta1 - mediated pathway ."
],
"offsets": [
[
0,
175
]
]
}
] |
[
{
"id": "split_0_train_9337_entity",
"type": "progene_text",
"text": [
"L1 major capsid protein"
],
"offsets": [
[
34,
57
]
],
"normalized": []
},
{
"id": "split_0_train_9338_entity",
"type": "progene_text",
"text": [
"Kap alpha2"
],
"offsets": [
[
91,
101
]
],
"normalized": []
},
{
"id": "split_0_train_9339_entity",
"type": "progene_text",
"text": [
"Kap alpha2beta1"
],
"offsets": [
[
139,
154
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6012
|
split_0_train_6012
|
[
{
"id": "split_0_train_6012_passage",
"type": "progene_text",
"text": [
"In this study , we discovered that HPV11 L1 capsomeres bind to Kap beta2 import receptor , known to mediate nuclear import of hnRNP A1 via interaction with its nuclear localization signal termed M9 ."
],
"offsets": [
[
0,
199
]
]
}
] |
[
{
"id": "split_0_train_9340_entity",
"type": "progene_text",
"text": [
"L1"
],
"offsets": [
[
41,
43
]
],
"normalized": []
},
{
"id": "split_0_train_9341_entity",
"type": "progene_text",
"text": [
"Kap beta2"
],
"offsets": [
[
63,
72
]
],
"normalized": []
},
{
"id": "split_0_train_9342_entity",
"type": "progene_text",
"text": [
"hnRNP A1"
],
"offsets": [
[
126,
134
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6013
|
split_0_train_6013
|
[
{
"id": "split_0_train_6013_passage",
"type": "progene_text",
"text": [
"Significantly , binding of HPV11 L1 capsomeres to Kap beta2 inhibited the nuclear import of Kap beta2 , and its specific M9 - containing cargo ."
],
"offsets": [
[
0,
144
]
]
}
] |
[
{
"id": "split_0_train_9343_entity",
"type": "progene_text",
"text": [
"L1"
],
"offsets": [
[
33,
35
]
],
"normalized": []
},
{
"id": "split_0_train_9344_entity",
"type": "progene_text",
"text": [
"Kap beta2"
],
"offsets": [
[
50,
59
]
],
"normalized": []
},
{
"id": "split_0_train_9345_entity",
"type": "progene_text",
"text": [
"Kap beta2"
],
"offsets": [
[
92,
101
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6014
|
split_0_train_6014
|
[
{
"id": "split_0_train_6014_passage",
"type": "progene_text",
"text": [
"Interestingly , HPV11 L1 capsomeres also interacted with Kap beta3 import receptor and inhibited Kap beta3 nuclear import ."
],
"offsets": [
[
0,
123
]
]
}
] |
[
{
"id": "split_0_train_9346_entity",
"type": "progene_text",
"text": [
"L1"
],
"offsets": [
[
22,
24
]
],
"normalized": []
},
{
"id": "split_0_train_9347_entity",
"type": "progene_text",
"text": [
"Kap beta3"
],
"offsets": [
[
57,
66
]
],
"normalized": []
},
{
"id": "split_0_train_9348_entity",
"type": "progene_text",
"text": [
"Kap beta3"
],
"offsets": [
[
97,
106
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6015
|
split_0_train_6015
|
[
{
"id": "split_0_train_6015_passage",
"type": "progene_text",
"text": [
"Moreover , the L1 capsomeres of high - risk HPV-16 shared these activities ."
],
"offsets": [
[
0,
76
]
]
}
] |
[
{
"id": "split_0_train_9349_entity",
"type": "progene_text",
"text": [
"L1"
],
"offsets": [
[
15,
17
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6016
|
split_0_train_6016
|
[
{
"id": "split_0_train_6016_passage",
"type": "progene_text",
"text": [
"These data suggest that HPV L1 major capsid proteins interact with Kap beta2 and Kap beta3 , and they may inhibit the Kap beta2 - and Kap beta3 - mediated nuclear import pathways during the productive phase of the viral life cycle when the virions are assembled and released ."
],
"offsets": [
[
0,
276
]
]
}
] |
[
{
"id": "split_0_train_9350_entity",
"type": "progene_text",
"text": [
"L1 major capsid proteins"
],
"offsets": [
[
28,
52
]
],
"normalized": []
},
{
"id": "split_0_train_9351_entity",
"type": "progene_text",
"text": [
"Kap beta2"
],
"offsets": [
[
67,
76
]
],
"normalized": []
},
{
"id": "split_0_train_9352_entity",
"type": "progene_text",
"text": [
"Kap beta3"
],
"offsets": [
[
81,
90
]
],
"normalized": []
},
{
"id": "split_0_train_9353_entity",
"type": "progene_text",
"text": [
"Kap beta2"
],
"offsets": [
[
118,
127
]
],
"normalized": []
},
{
"id": "split_0_train_9354_entity",
"type": "progene_text",
"text": [
"Kap beta3"
],
"offsets": [
[
134,
143
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6017
|
split_0_train_6017
|
[
{
"id": "split_0_train_6017_passage",
"type": "progene_text",
"text": [
"Crystal structure of the human natural killer cell activating receptor KIR2DS2 ( CD158j ) ."
],
"offsets": [
[
0,
91
]
]
}
] |
[
{
"id": "split_0_train_9355_entity",
"type": "progene_text",
"text": [
"KIR2DS2"
],
"offsets": [
[
71,
78
]
],
"normalized": []
},
{
"id": "split_0_train_9356_entity",
"type": "progene_text",
"text": [
"CD158j"
],
"offsets": [
[
81,
87
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6018
|
split_0_train_6018
|
[
{
"id": "split_0_train_6018_passage",
"type": "progene_text",
"text": [
"Killer cell Ig - like receptors ( KIRs ) regulate the function of human natural killer and T cell subsets ."
],
"offsets": [
[
0,
107
]
]
}
] |
[
{
"id": "split_0_train_9357_entity",
"type": "progene_text",
"text": [
"Killer cell Ig - like receptors"
],
"offsets": [
[
0,
31
]
],
"normalized": []
},
{
"id": "split_0_train_9358_entity",
"type": "progene_text",
"text": [
"KIRs"
],
"offsets": [
[
34,
38
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6019
|
split_0_train_6019
|
[
{
"id": "split_0_train_6019_passage",
"type": "progene_text",
"text": [
"A feature of the KIR locus is the clustering of homologous genes encoding for inhibitory and activating KIR ."
],
"offsets": [
[
0,
109
]
]
}
] |
[
{
"id": "split_0_train_9359_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
17,
20
]
],
"normalized": []
},
{
"id": "split_0_train_9360_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
104,
107
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6020
|
split_0_train_6020
|
[
{
"id": "split_0_train_6020_passage",
"type": "progene_text",
"text": [
"Inhibitory and activating KIR differ for ligand specificities and/or affinities ."
],
"offsets": [
[
0,
81
]
]
}
] |
[
{
"id": "split_0_train_9361_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
26,
29
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6021
|
split_0_train_6021
|
[
{
"id": "split_0_train_6021_passage",
"type": "progene_text",
"text": [
"In particular , we show here with KIR tetramers that activating KIR2DS2 does not bind HLA-Cw3 molecules recognized by inhibitory KIR2DL2 , despite 99 % extracellular amino acid identity ."
],
"offsets": [
[
0,
187
]
]
}
] |
[
{
"id": "split_0_train_9362_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
34,
37
]
],
"normalized": []
},
{
"id": "split_0_train_9363_entity",
"type": "progene_text",
"text": [
"KIR2DS2"
],
"offsets": [
[
64,
71
]
],
"normalized": []
},
{
"id": "split_0_train_9364_entity",
"type": "progene_text",
"text": [
"HLA-Cw3"
],
"offsets": [
[
86,
93
]
],
"normalized": []
},
{
"id": "split_0_train_9365_entity",
"type": "progene_text",
"text": [
"KIR2DL2"
],
"offsets": [
[
129,
136
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6022
|
split_0_train_6022
|
[
{
"id": "split_0_train_6022_passage",
"type": "progene_text",
"text": [
"We also report the 2.3 - A structure of KIR2DS2 , which reveals subtle displacements of two residues ( Tyr45 and Gln71 ) involved in the interaction of KIR2DL2 with HLA-Cw3 ."
],
"offsets": [
[
0,
174
]
]
}
] |
[
{
"id": "split_0_train_9366_entity",
"type": "progene_text",
"text": [
"KIR2DS2"
],
"offsets": [
[
40,
47
]
],
"normalized": []
},
{
"id": "split_0_train_9367_entity",
"type": "progene_text",
"text": [
"KIR2DL2"
],
"offsets": [
[
152,
159
]
],
"normalized": []
},
{
"id": "split_0_train_9368_entity",
"type": "progene_text",
"text": [
"HLA-Cw3"
],
"offsets": [
[
165,
172
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6023
|
split_0_train_6023
|
[
{
"id": "split_0_train_6023_passage",
"type": "progene_text",
"text": [
"These results show that KIR molecules cannot tolerate any variability in their three - dimensional structure without altering their MHC class I recognition capacities ."
],
"offsets": [
[
0,
168
]
]
}
] |
[
{
"id": "split_0_train_9369_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
24,
27
]
],
"normalized": []
},
{
"id": "split_0_train_9370_entity",
"type": "progene_text",
"text": [
"MHC class I"
],
"offsets": [
[
132,
143
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6024
|
split_0_train_6024
|
[
{
"id": "split_0_train_6024_passage",
"type": "progene_text",
"text": [
"Therefore , the mode of recognition used by KIR largely differs from the conformational changes that characterize T cell receptor or NKG2D interaction with their respective ligands ."
],
"offsets": [
[
0,
182
]
]
}
] |
[
{
"id": "split_0_train_9371_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
44,
47
]
],
"normalized": []
},
{
"id": "split_0_train_9372_entity",
"type": "progene_text",
"text": [
"NKG2D"
],
"offsets": [
[
133,
138
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6025
|
split_0_train_6025
|
[
{
"id": "split_0_train_6025_passage",
"type": "progene_text",
"text": [
"The sensor protein KdpD inserts into the Escherichia coli membrane independent of the Sec translocase and YidC ."
],
"offsets": [
[
0,
112
]
]
}
] |
[
{
"id": "split_0_train_9373_entity",
"type": "progene_text",
"text": [
"KdpD"
],
"offsets": [
[
19,
23
]
],
"normalized": []
},
{
"id": "split_0_train_9374_entity",
"type": "progene_text",
"text": [
"Sec translocase"
],
"offsets": [
[
86,
101
]
],
"normalized": []
},
{
"id": "split_0_train_9375_entity",
"type": "progene_text",
"text": [
"YidC"
],
"offsets": [
[
106,
110
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6026
|
split_0_train_6026
|
[
{
"id": "split_0_train_6026_passage",
"type": "progene_text",
"text": [
"KdpD is a sensor kinase protein in the inner membrane of Escherichia coli containing four transmembrane regions ."
],
"offsets": [
[
0,
113
]
]
}
] |
[
{
"id": "split_0_train_9376_entity",
"type": "progene_text",
"text": [
"KdpD"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_9377_entity",
"type": "progene_text",
"text": [
"sensor kinase"
],
"offsets": [
[
10,
23
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6027
|
split_0_train_6027
|
[
{
"id": "split_0_train_6027_passage",
"type": "progene_text",
"text": [
"The periplasmic loops connecting the transmembrane regions are intriguingly short and protease mapping allowed us to only follow the translocation of the second periplasmic loop ."
],
"offsets": [
[
0,
179
]
]
}
] |
[
{
"id": "split_0_train_9378_entity",
"type": "progene_text",
"text": [
"protease"
],
"offsets": [
[
86,
94
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6028
|
split_0_train_6028
|
[
{
"id": "split_0_train_6028_passage",
"type": "progene_text",
"text": [
"The results show that neither the Sec translocase nor the YidC protein are required for membrane insertion of the second loop of KdpD ."
],
"offsets": [
[
0,
135
]
]
}
] |
[
{
"id": "split_0_train_9379_entity",
"type": "progene_text",
"text": [
"Sec translocase"
],
"offsets": [
[
34,
49
]
],
"normalized": []
},
{
"id": "split_0_train_9380_entity",
"type": "progene_text",
"text": [
"YidC"
],
"offsets": [
[
58,
62
]
],
"normalized": []
},
{
"id": "split_0_train_9381_entity",
"type": "progene_text",
"text": [
"KdpD"
],
"offsets": [
[
129,
133
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6029
|
split_0_train_6029
|
[
{
"id": "split_0_train_6029_passage",
"type": "progene_text",
"text": [
"To study the translocation of the first periplasmic loop a short HA epitope tag was genetically introduced into this region ."
],
"offsets": [
[
0,
125
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6030
|
split_0_train_6030
|
[
{
"id": "split_0_train_6030_passage",
"type": "progene_text",
"text": [
"The results show that also the first loop was translocated independently of YidC and the Sec translocase ."
],
"offsets": [
[
0,
106
]
]
}
] |
[
{
"id": "split_0_train_9382_entity",
"type": "progene_text",
"text": [
"YidC"
],
"offsets": [
[
76,
80
]
],
"normalized": []
},
{
"id": "split_0_train_9383_entity",
"type": "progene_text",
"text": [
"Sec translocase"
],
"offsets": [
[
89,
104
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6031
|
split_0_train_6031
|
[
{
"id": "split_0_train_6031_passage",
"type": "progene_text",
"text": [
"We conclude that KdpD resembles a new class of membrane proteins that insert into the membrane without enzymatic assistance by the known translocases ."
],
"offsets": [
[
0,
151
]
]
}
] |
[
{
"id": "split_0_train_9384_entity",
"type": "progene_text",
"text": [
"KdpD"
],
"offsets": [
[
17,
21
]
],
"normalized": []
},
{
"id": "split_0_train_9385_entity",
"type": "progene_text",
"text": [
"translocases"
],
"offsets": [
[
137,
149
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6032
|
split_0_train_6032
|
[
{
"id": "split_0_train_6032_passage",
"type": "progene_text",
"text": [
"When the second periplasmic loop was extended by an epitope tag to 27 amino acid residues , the membrane insertion of this loop of KdpD depended on SecE and YidC ."
],
"offsets": [
[
0,
163
]
]
}
] |
[
{
"id": "split_0_train_9386_entity",
"type": "progene_text",
"text": [
"KdpD"
],
"offsets": [
[
131,
135
]
],
"normalized": []
},
{
"id": "split_0_train_9387_entity",
"type": "progene_text",
"text": [
"SecE"
],
"offsets": [
[
148,
152
]
],
"normalized": []
},
{
"id": "split_0_train_9388_entity",
"type": "progene_text",
"text": [
"YidC"
],
"offsets": [
[
157,
161
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6033
|
split_0_train_6033
|
[
{
"id": "split_0_train_6033_passage",
"type": "progene_text",
"text": [
"To test whether the two periplasmic regions are translocated independently of each other , the KdpD protein was split between helix 2 and 3 into two approximately equal - sized fragments ."
],
"offsets": [
[
0,
188
]
]
}
] |
[
{
"id": "split_0_train_9389_entity",
"type": "progene_text",
"text": [
"KdpD"
],
"offsets": [
[
95,
99
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6034
|
split_0_train_6034
|
[
{
"id": "split_0_train_6034_passage",
"type": "progene_text",
"text": [
"Both constructed fragments , which contained KdpD - N ( residues 1 - 448 of KdpD ) and the KdpD - C ( residues 444-894 of KdpD ) , readily inserted into the membrane ."
],
"offsets": [
[
0,
167
]
]
}
] |
[
{
"id": "split_0_train_9390_entity",
"type": "progene_text",
"text": [
"KdpD"
],
"offsets": [
[
45,
49
]
],
"normalized": []
},
{
"id": "split_0_train_9391_entity",
"type": "progene_text",
"text": [
"KdpD"
],
"offsets": [
[
91,
95
]
],
"normalized": []
},
{
"id": "split_0_train_9392_entity",
"type": "progene_text",
"text": [
"KdpD"
],
"offsets": [
[
122,
126
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6035
|
split_0_train_6035
|
[
{
"id": "split_0_train_6035_passage",
"type": "progene_text",
"text": [
"Similar to the epitope - tagged KdpD protein , only KdpD - C depended on the presence of the Sec translocase and YidC ."
],
"offsets": [
[
0,
119
]
]
}
] |
[
{
"id": "split_0_train_9393_entity",
"type": "progene_text",
"text": [
"KdpD"
],
"offsets": [
[
32,
36
]
],
"normalized": []
},
{
"id": "split_0_train_9394_entity",
"type": "progene_text",
"text": [
"KdpD"
],
"offsets": [
[
52,
56
]
],
"normalized": []
},
{
"id": "split_0_train_9395_entity",
"type": "progene_text",
"text": [
"Sec translocase"
],
"offsets": [
[
93,
108
]
],
"normalized": []
},
{
"id": "split_0_train_9396_entity",
"type": "progene_text",
"text": [
"YidC"
],
"offsets": [
[
113,
117
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6036
|
split_0_train_6036
|
[
{
"id": "split_0_train_6036_passage",
"type": "progene_text",
"text": [
"This confirms that the four transmembrane helices of KdpD are inserted pairwise , each translocation event involving two transmembrane helices and a periplasmic loop ."
],
"offsets": [
[
0,
167
]
]
}
] |
[
{
"id": "split_0_train_9397_entity",
"type": "progene_text",
"text": [
"KdpD"
],
"offsets": [
[
53,
57
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6037
|
split_0_train_6037
|
[
{
"id": "split_0_train_6037_passage",
"type": "progene_text",
"text": [
"2-Amino-3-benzoylthiophene allosteric enhancers of A1 adenosine agonist binding : new 3 , 4 - , and 5 - modifications ."
],
"offsets": [
[
0,
119
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6038
|
split_0_train_6038
|
[
{
"id": "split_0_train_6038_passage",
"type": "progene_text",
"text": [
"2-Amino-3-aroylthiophenes are agonist allosteric enhancers ( AE ) at the A(1) adenosine receptor ( A(1) AR ) ."
],
"offsets": [
[
0,
110
]
]
}
] |
[
{
"id": "split_0_train_9398_entity",
"type": "progene_text",
"text": [
"A(1) adenosine receptor"
],
"offsets": [
[
73,
96
]
],
"normalized": []
},
{
"id": "split_0_train_9399_entity",
"type": "progene_text",
"text": [
"A(1) AR"
],
"offsets": [
[
99,
106
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6039
|
split_0_train_6039
|
[
{
"id": "split_0_train_6039_passage",
"type": "progene_text",
"text": [
"Here we report the syntheses of three kinds of novel 2-aminothiophenes and assays of their AE activity at the human A(1) AR ( hA(1)AR ) , namely , (1) 2-amino-4,5-diphenylthiophene-3-carboxylates , 3a-h , (2) 2-amino-3-benzoyl-4,5-diphenylthiophenes , 7a-p , and ( 3 ) 2-amino-5-bromo-3-benzoyl-4-phenylthiophenes , 10a-h ."
],
"offsets": [
[
0,
323
]
]
}
] |
[
{
"id": "split_0_train_9400_entity",
"type": "progene_text",
"text": [
"A(1) AR"
],
"offsets": [
[
116,
123
]
],
"normalized": []
},
{
"id": "split_0_train_9401_entity",
"type": "progene_text",
"text": [
"hA(1)AR"
],
"offsets": [
[
126,
133
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6040
|
split_0_train_6040
|
[
{
"id": "split_0_train_6040_passage",
"type": "progene_text",
"text": [
"An in vitro assay employing the A(1) AR agonist [(125)I]ABA and membranes from CHO-K1 cells stably expressing the hA(1) AR measured an index of AE activity , the ability of a candidate AE to stabilize the agonist - A(1)AR - G protein ternary complex , scored as the percentage of ternary complex remaining after 10 min of dissociation initiated by CPX and GTPgammaS ."
],
"offsets": [
[
0,
367
]
]
}
] |
[
{
"id": "split_0_train_9402_entity",
"type": "progene_text",
"text": [
"A(1) AR"
],
"offsets": [
[
32,
39
]
],
"normalized": []
},
{
"id": "split_0_train_9403_entity",
"type": "progene_text",
"text": [
"hA(1) AR"
],
"offsets": [
[
114,
122
]
],
"normalized": []
},
{
"id": "split_0_train_9404_entity",
"type": "progene_text",
"text": [
"A(1)AR"
],
"offsets": [
[
215,
221
]
],
"normalized": []
},
{
"id": "split_0_train_9405_entity",
"type": "progene_text",
"text": [
"G protein"
],
"offsets": [
[
224,
233
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6041
|
split_0_train_6041
|
[
{
"id": "split_0_train_6041_passage",
"type": "progene_text",
"text": [
"The AE activity score of 2-amino-4,5-dimethyl-3-(3-trifluoromethylbenzoyl ) thiophene ( PD 81 , 723 ) , which was 19 % , served as a standard for comparison ."
],
"offsets": [
[
0,
158
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6042
|
split_0_train_6042
|
[
{
"id": "split_0_train_6042_passage",
"type": "progene_text",
"text": [
"Two 3-carboxythiophene 3-trifluoromethylbenzyl esters , 3d ( 49 % ) and 3f ( 63 % ) , had substantial AE activity ."
],
"offsets": [
[
0,
115
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6043
|
split_0_train_6043
|
[
{
"id": "split_0_train_6043_passage",
"type": "progene_text",
"text": [
"The 3-(1-naphthoyl ) substituent of 7e ( 52 % ) also supported AE activity ."
],
"offsets": [
[
0,
76
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6044
|
split_0_train_6044
|
[
{
"id": "split_0_train_6044_passage",
"type": "progene_text",
"text": [
"Compounds in series 3 tended to be more potent , 10a and 10c having scores of 91 and 80 % , respectively ."
],
"offsets": [
[
0,
106
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6045
|
split_0_train_6045
|
[
{
"id": "split_0_train_6045_passage",
"type": "progene_text",
"text": [
"The activity of 2-amino-5-bromo-3-ethoxycarbonyl-4-(3-nitrophenyl ) thiophene , 10h ( 26 % ) , is an exception to the rule that a 3-ethoxycarbonyl substituent cannot support AE activity ."
],
"offsets": [
[
0,
187
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6046
|
split_0_train_6046
|
[
{
"id": "split_0_train_6046_passage",
"type": "progene_text",
"text": [
"Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II ."
],
"offsets": [
[
0,
124
]
]
}
] |
[
{
"id": "split_0_train_9406_entity",
"type": "progene_text",
"text": [
"histone H3"
],
"offsets": [
[
15,
25
]
],
"normalized": []
},
{
"id": "split_0_train_9407_entity",
"type": "progene_text",
"text": [
"Set2"
],
"offsets": [
[
29,
33
]
],
"normalized": []
},
{
"id": "split_0_train_9408_entity",
"type": "progene_text",
"text": [
"RNA polymerase II"
],
"offsets": [
[
105,
122
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6047
|
split_0_train_6047
|
[
{
"id": "split_0_train_6047_passage",
"type": "progene_text",
"text": [
"Set2 methylates Lys36 of histone H3 ."
],
"offsets": [
[
0,
37
]
]
}
] |
[
{
"id": "split_0_train_9409_entity",
"type": "progene_text",
"text": [
"Set2"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_9410_entity",
"type": "progene_text",
"text": [
"histone H3"
],
"offsets": [
[
25,
35
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6048
|
split_0_train_6048
|
[
{
"id": "split_0_train_6048_passage",
"type": "progene_text",
"text": [
"We show here that yeast Set2 copurifies with RNA polymerase II ( RNAPII ) ."
],
"offsets": [
[
0,
75
]
]
}
] |
[
{
"id": "split_0_train_9411_entity",
"type": "progene_text",
"text": [
"Set2"
],
"offsets": [
[
24,
28
]
],
"normalized": []
},
{
"id": "split_0_train_9412_entity",
"type": "progene_text",
"text": [
"RNA polymerase II"
],
"offsets": [
[
45,
62
]
],
"normalized": []
},
{
"id": "split_0_train_9413_entity",
"type": "progene_text",
"text": [
"RNAPII"
],
"offsets": [
[
65,
71
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6049
|
split_0_train_6049
|
[
{
"id": "split_0_train_6049_passage",
"type": "progene_text",
"text": [
"Chromatin immunoprecipitation analyses demonstrated that Set2 and histone H3 Lys36 methylation are associated with the coding regions of several genes that were tested and correlate with active transcription ."
],
"offsets": [
[
0,
209
]
]
}
] |
[
{
"id": "split_0_train_9414_entity",
"type": "progene_text",
"text": [
"Set2"
],
"offsets": [
[
57,
61
]
],
"normalized": []
},
{
"id": "split_0_train_9415_entity",
"type": "progene_text",
"text": [
"histone H3"
],
"offsets": [
[
66,
76
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6050
|
split_0_train_6050
|
[
{
"id": "split_0_train_6050_passage",
"type": "progene_text",
"text": [
"Both depend , as well , on the Paf1 elongation factor complex ."
],
"offsets": [
[
0,
63
]
]
}
] |
[
{
"id": "split_0_train_9416_entity",
"type": "progene_text",
"text": [
"Paf1 elongation factor complex"
],
"offsets": [
[
31,
61
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6051
|
split_0_train_6051
|
[
{
"id": "split_0_train_6051_passage",
"type": "progene_text",
"text": [
"The C terminus of Set2 , which contains a WW domain , is also required for effective Lys36 methylation ."
],
"offsets": [
[
0,
104
]
]
}
] |
[
{
"id": "split_0_train_9417_entity",
"type": "progene_text",
"text": [
"Set2"
],
"offsets": [
[
18,
22
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6052
|
split_0_train_6052
|
[
{
"id": "split_0_train_6052_passage",
"type": "progene_text",
"text": [
"Deletion of CTK1 , encoding an RNAPII CTD kinase , prevents Lys36 methylation and Set2 recruitment , suggesting that methylation may be triggered by contact of the WW domain or C terminus of Set2 with Ser2 - phosphorylated CTD ."
],
"offsets": [
[
0,
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191,
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] |
[] |
[] |
[] |
split_0_train_6053
|
split_0_train_6053
|
[
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0,
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"text": [
"beta-galactosidase"
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75,
93
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}
] |
[] |
[] |
[] |
split_0_train_6054
|
split_0_train_6054
|
[
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"In synthetic genetic array ( SGA ) analysis , synthetic growth defects were obtained when a set2 deletion was combined with deletions of all five components of the Paf1 complex , the chromodomain elongation factor Chd1 , the putative elongation factor Soh1 , the Bre1 or Lge1 components of the histone H2B ubiquitination complex , or the histone H2A variant Htz1 ."
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"Htz1"
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358,
362
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}
] |
[] |
[] |
[] |
split_0_train_6055
|
split_0_train_6055
|
[
{
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"type": "progene_text",
"text": [
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0,
162
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"text": [
"RNAPII"
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[
154,
160
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}
] |
[] |
[] |
[] |
split_0_train_6056
|
split_0_train_6056
|
[
{
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"type": "progene_text",
"text": [
"Intramembrane proteolysis by presenilin and presenilin - like proteases ."
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0,
73
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"type": "progene_text",
"text": [
"proteases"
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62,
71
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}
] |
[] |
[] |
[] |
split_0_train_6057
|
split_0_train_6057
|
[
{
"id": "split_0_train_6057_passage",
"type": "progene_text",
"text": [
"Regulated intramembrane proteolysis is a novel mechanism involving proteases that hydrolyze their substrates in a hydrophobic environment ."
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0,
139
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}
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"type": "progene_text",
"text": [
"proteases"
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[
67,
76
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}
] |
[] |
[] |
[] |
split_0_train_6058
|
split_0_train_6058
|
[
{
"id": "split_0_train_6058_passage",
"type": "progene_text",
"text": [
"Presenilin ( PS ) 1 and PS 2 are required for intramembrane cleavage of an increasing number of type I membrane proteins , including the amyloid precursor protein of Alzheimer ' s disease and the Notch receptor , which signals during differentiation and development ."
],
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[
0,
267
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]
}
] |
[
{
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{
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24,
28
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{
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137,
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{
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"type": "progene_text",
"text": [
"Notch"
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"offsets": [
[
196,
201
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6059
|
split_0_train_6059
|
[
{
"id": "split_0_train_6059_passage",
"type": "progene_text",
"text": [
"Mutagenesis , affinity labeling , biochemical isolation , and reconstitution in cells reveal that PS , in complex with co - factors nicastrin , APH - 1 and PEN - 2 , apparently contains the active site of gamma - secretase , a novel membrane aspartyl protease ."
],
"offsets": [
[
0,
261
]
]
}
] |
[
{
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98,
100
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{
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132,
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{
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"text": [
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144,
151
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},
{
"id": "split_0_train_9454_entity",
"type": "progene_text",
"text": [
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156,
163
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},
{
"id": "split_0_train_9455_entity",
"type": "progene_text",
"text": [
"gamma - secretase"
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205,
222
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},
{
"id": "split_0_train_9456_entity",
"type": "progene_text",
"text": [
"aspartyl protease"
],
"offsets": [
[
242,
259
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6060
|
split_0_train_6060
|
[
{
"id": "split_0_train_6060_passage",
"type": "progene_text",
"text": [
"In addition , other related aspartyl proteases have been identified ."
],
"offsets": [
[
0,
69
]
]
}
] |
[
{
"id": "split_0_train_9457_entity",
"type": "progene_text",
"text": [
"aspartyl proteases"
],
"offsets": [
[
28,
46
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6061
|
split_0_train_6061
|
[
{
"id": "split_0_train_6061_passage",
"type": "progene_text",
"text": [
"These include members of the type-4 prepilin peptidase family in bacteria , which are known proteases and carry a GD motif conserved in PS ."
],
"offsets": [
[
0,
140
]
]
}
] |
[
{
"id": "split_0_train_9458_entity",
"type": "progene_text",
"text": [
"type-4 prepilin peptidase family"
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29,
61
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{
"id": "split_0_train_9459_entity",
"type": "progene_text",
"text": [
"proteases"
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92,
101
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},
{
"id": "split_0_train_9460_entity",
"type": "progene_text",
"text": [
"PS"
],
"offsets": [
[
136,
138
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6062
|
split_0_train_6062
|
[
{
"id": "split_0_train_6062_passage",
"type": "progene_text",
"text": [
"A group of multi - pass membrane proteins found in eukaryotes also contain YD and LGXGD motifs in two transmembrane domains that are conserved in PS and postulated to constitute an aspartyl protease active site ."
],
"offsets": [
[
0,
212
]
]
}
] |
[
{
"id": "split_0_train_9461_entity",
"type": "progene_text",
"text": [
"PS"
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"offsets": [
[
146,
148
]
],
"normalized": []
},
{
"id": "split_0_train_9462_entity",
"type": "progene_text",
"text": [
"aspartyl protease"
],
"offsets": [
[
181,
198
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6063
|
split_0_train_6063
|
[
{
"id": "split_0_train_6063_passage",
"type": "progene_text",
"text": [
"Among these is signal peptide peptidase ( SPP ) , which cleaves remnant signal peptides derived from signal - peptidase - mediated ectodomain shedding ."
],
"offsets": [
[
0,
152
]
]
}
] |
[
{
"id": "split_0_train_9463_entity",
"type": "progene_text",
"text": [
"signal peptide peptidase"
],
"offsets": [
[
15,
39
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],
"normalized": []
},
{
"id": "split_0_train_9464_entity",
"type": "progene_text",
"text": [
"SPP"
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[
42,
45
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],
"normalized": []
},
{
"id": "split_0_train_9465_entity",
"type": "progene_text",
"text": [
"signal - peptidase"
],
"offsets": [
[
101,
119
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6064
|
split_0_train_6064
|
[
{
"id": "split_0_train_6064_passage",
"type": "progene_text",
"text": [
"SPP cuts type II membrane proteins , illustrating that PS - like proteases play a key role in intramembrane proteolysis of single - pass membrane proteins oriented in either direction ."
],
"offsets": [
[
0,
185
]
]
}
] |
[
{
"id": "split_0_train_9466_entity",
"type": "progene_text",
"text": [
"SPP"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "split_0_train_9467_entity",
"type": "progene_text",
"text": [
"PS"
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"offsets": [
[
55,
57
]
],
"normalized": []
},
{
"id": "split_0_train_9468_entity",
"type": "progene_text",
"text": [
"proteases"
],
"offsets": [
[
65,
74
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6065
|
split_0_train_6065
|
[
{
"id": "split_0_train_6065_passage",
"type": "progene_text",
"text": [
"Structural and biochemical dissection of photorespiration in hybrids differing in genome constitution between Diplotaxis tenuifolia ( C3-C4 ) and radish ( C3 ) ."
],
"offsets": [
[
0,
161
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6066
|
split_0_train_6066
|
[
{
"id": "split_0_train_6066_passage",
"type": "progene_text",
"text": [
"We compared the structural , biochemical , and physiological characteristics involved in photorespiration of intergeneric hybrids differing in genome constitution ( DtDtR , DtDtRR , and DtRR ) between the C(3)-C(4) intermediate species Diplotaxis tenuifolia ( DtDt ) and the C(3) species radish ( Raphanus sativus ; RR ) ."
],
"offsets": [
[
0,
322
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6067
|
split_0_train_6067
|
[
{
"id": "split_0_train_6067_passage",
"type": "progene_text",
"text": [
"The bundle sheath ( BS ) cells in D. tenuifolia included many centripetally located chloroplasts and mitochondria , but those of radish had only a few chloroplasts and mitochondria ."
],
"offsets": [
[
0,
182
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6068
|
split_0_train_6068
|
[
{
"id": "split_0_train_6068_passage",
"type": "progene_text",
"text": [
"In the hybrids , the numbers of chloroplasts and mitochondria , the ratio of centripetally located organelles to total organelles , and the mitochondrial size in the BS cells increased with an increase in the constitution ratio of the Dt : R genome ."
],
"offsets": [
[
0,
250
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6069
|
split_0_train_6069
|
[
{
"id": "split_0_train_6069_passage",
"type": "progene_text",
"text": [
"The P-protein of glycine decarboxylase ( GDC ) was confined to the BS mitochondria in D. tenuifolia , whereas in radish , it accumulated more densely in the mesophyll than in the BS mitochondria ."
],
"offsets": [
[
0,
196
]
]
}
] |
[
{
"id": "split_0_train_9469_entity",
"type": "progene_text",
"text": [
"P-protein of glycine decarboxylase"
],
"offsets": [
[
4,
38
]
],
"normalized": []
},
{
"id": "split_0_train_9470_entity",
"type": "progene_text",
"text": [
"GDC"
],
"offsets": [
[
41,
44
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6070
|
split_0_train_6070
|
[
{
"id": "split_0_train_6070_passage",
"type": "progene_text",
"text": [
"In the hybrids , more intense accumulation of GDC in the BS relative to the mesophyll mitochondria occurred with an increase in the Dt : R ratio ."
],
"offsets": [
[
0,
146
]
]
}
] |
[
{
"id": "split_0_train_9471_entity",
"type": "progene_text",
"text": [
"GDC"
],
"offsets": [
[
46,
49
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6071
|
split_0_train_6071
|
[
{
"id": "split_0_train_6071_passage",
"type": "progene_text",
"text": [
"These structural and biochemical features in the hybrids were reflected in the gas exchange characteristics of leaves , such as the CO ( 2 ) compensation point ."
],
"offsets": [
[
0,
161
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6072
|
split_0_train_6072
|
[
{
"id": "split_0_train_6072_passage",
"type": "progene_text",
"text": [
"Our data indicate that the leaf structure , the intercellular pattern of GDC expression , and the gas exchange characteristics of C ( 3 ) - C ( 4 ) intermediate photosynthesis are inherited in the hybrids depending on the constitution ratio of the parent genomes ."
],
"offsets": [
[
0,
264
]
]
}
] |
[
{
"id": "split_0_train_9472_entity",
"type": "progene_text",
"text": [
"GDC"
],
"offsets": [
[
73,
76
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6073
|
split_0_train_6073
|
[
{
"id": "split_0_train_6073_passage",
"type": "progene_text",
"text": [
"Our findings also demonstrate that the apparent reduced photorespiration in C(3)-C(4) intermediate plants is mainly due to the structural differentiation of mitochondria and chloroplasts in the BS cells combined with the BS - dominant expression of GDC ."
],
"offsets": [
[
0,
254
]
]
}
] |
[
{
"id": "split_0_train_9473_entity",
"type": "progene_text",
"text": [
"GDC"
],
"offsets": [
[
249,
252
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6074
|
split_0_train_6074
|
[
{
"id": "split_0_train_6074_passage",
"type": "progene_text",
"text": [
"Apolipoprotein D levels are elevated in prefrontal cortex of subjects with Alzheimer 's disease : no relation to apolipoprotein E expression or genotype ."
],
"offsets": [
[
0,
154
]
]
}
] |
[
{
"id": "split_0_train_9474_entity",
"type": "progene_text",
"text": [
"Apolipoprotein D"
],
"offsets": [
[
0,
16
]
],
"normalized": []
},
{
"id": "split_0_train_9475_entity",
"type": "progene_text",
"text": [
"apolipoprotein E"
],
"offsets": [
[
113,
129
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6075
|
split_0_train_6075
|
[
{
"id": "split_0_train_6075_passage",
"type": "progene_text",
"text": [
"BACKGROUND :"
],
"offsets": [
[
0,
12
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6076
|
split_0_train_6076
|
[
{
"id": "split_0_train_6076_passage",
"type": "progene_text",
"text": [
"Apolipoprotein E ( apoE ) has been implicated in the pathology of AD ever since inheritance of the epsilon4 allele was shown to be an important risk factor for the development of AD ."
],
"offsets": [
[
0,
183
]
]
}
] |
[
{
"id": "split_0_train_9476_entity",
"type": "progene_text",
"text": [
"Apolipoprotein E"
],
"offsets": [
[
0,
16
]
],
"normalized": []
},
{
"id": "split_0_train_9477_entity",
"type": "progene_text",
"text": [
"apoE"
],
"offsets": [
[
19,
23
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6077
|
split_0_train_6077
|
[
{
"id": "split_0_train_6077_passage",
"type": "progene_text",
"text": [
"Apolipoprotein D ( apoD ) is elevated in association with several central nervous system disorders , including Alzheimer 's disease ( AD ) , and has been proposed to be an especially robust marker for brain regions specifically affected by particular neuropathologies ."
],
"offsets": [
[
0,
269
]
]
}
] |
[
{
"id": "split_0_train_9478_entity",
"type": "progene_text",
"text": [
"Apolipoprotein D"
],
"offsets": [
[
0,
16
]
],
"normalized": []
},
{
"id": "split_0_train_9479_entity",
"type": "progene_text",
"text": [
"apoD"
],
"offsets": [
[
19,
23
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6078
|
split_0_train_6078
|
[
{
"id": "split_0_train_6078_passage",
"type": "progene_text",
"text": [
"Progressive cognitive decline is the core clinical feature of AD and is associated with disturbances in the prefrontal cortex ."
],
"offsets": [
[
0,
127
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6079
|
split_0_train_6079
|
[
{
"id": "split_0_train_6079_passage",
"type": "progene_text",
"text": [
"METHODS :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6080
|
split_0_train_6080
|
[
{
"id": "split_0_train_6080_passage",
"type": "progene_text",
"text": [
"We measured apoD levels in prefrontal cortex samples obtained postmortem from 20 autopsy - confirmed AD subjects and 40 control subjects ."
],
"offsets": [
[
0,
138
]
]
}
] |
[
{
"id": "split_0_train_9480_entity",
"type": "progene_text",
"text": [
"apoD"
],
"offsets": [
[
12,
16
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6081
|
split_0_train_6081
|
[
{
"id": "split_0_train_6081_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6082
|
split_0_train_6082
|
[
{
"id": "split_0_train_6082_passage",
"type": "progene_text",
"text": [
"Enzyme - linked immunosorbent assay analysis revealed a significant increase in apoD expression in AD subjects compared with control subjects ( .218 +/- .029 microg / mg protein vs.117 +/- .011 microg / mg protein ; p = 0003 ) ."
],
"offsets": [
[
0,
228
]
]
}
] |
[
{
"id": "split_0_train_9481_entity",
"type": "progene_text",
"text": [
"apoD"
],
"offsets": [
[
80,
84
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6083
|
split_0_train_6083
|
[
{
"id": "split_0_train_6083_passage",
"type": "progene_text",
"text": [
"There was no significant difference in apoD expression between early - onset and late - onset Alzheimer 's subjects ."
],
"offsets": [
[
0,
117
]
]
}
] |
[
{
"id": "split_0_train_9482_entity",
"type": "progene_text",
"text": [
"apoD"
],
"offsets": [
[
39,
43
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6084
|
split_0_train_6084
|
[
{
"id": "split_0_train_6084_passage",
"type": "progene_text",
"text": [
"Apolipoprotein D expression levels were not correlated with apoE levels , nor were they correlated with inheritance of the APOE epsilon4 allele ."
],
"offsets": [
[
0,
145
]
]
}
] |
[
{
"id": "split_0_train_9483_entity",
"type": "progene_text",
"text": [
"Apolipoprotein D"
],
"offsets": [
[
0,
16
]
],
"normalized": []
},
{
"id": "split_0_train_9484_entity",
"type": "progene_text",
"text": [
"apoE"
],
"offsets": [
[
60,
64
]
],
"normalized": []
},
{
"id": "split_0_train_9485_entity",
"type": "progene_text",
"text": [
"APOE"
],
"offsets": [
[
123,
127
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6085
|
split_0_train_6085
|
[
{
"id": "split_0_train_6085_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6086
|
split_0_train_6086
|
[
{
"id": "split_0_train_6086_passage",
"type": "progene_text",
"text": [
"These findings suggest that apoD may be related to the cognitive decline observed in AD patients and that apoD and apoE likely play different roles in the pathogenesis of AD ."
],
"offsets": [
[
0,
175
]
]
}
] |
[
{
"id": "split_0_train_9486_entity",
"type": "progene_text",
"text": [
"apoD"
],
"offsets": [
[
28,
32
]
],
"normalized": []
},
{
"id": "split_0_train_9487_entity",
"type": "progene_text",
"text": [
"apoD"
],
"offsets": [
[
106,
110
]
],
"normalized": []
},
{
"id": "split_0_train_9488_entity",
"type": "progene_text",
"text": [
"apoE"
],
"offsets": [
[
115,
119
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6087
|
split_0_train_6087
|
[
{
"id": "split_0_train_6087_passage",
"type": "progene_text",
"text": [
"New members of the Escherichia coli sigmaE regulon identified by a two - plasmid system ."
],
"offsets": [
[
0,
89
]
]
}
] |
[
{
"id": "split_0_train_9489_entity",
"type": "progene_text",
"text": [
"sigmaE"
],
"offsets": [
[
36,
42
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6088
|
split_0_train_6088
|
[
{
"id": "split_0_train_6088_passage",
"type": "progene_text",
"text": [
"A previously established method , based on a two - plasmid system , was used to identify promoters recognized by RNA polymerase containing the extracytoplasmic stress response sigma factor sigmaE in Escherichia coli ."
],
"offsets": [
[
0,
217
]
]
}
] |
[
{
"id": "split_0_train_9490_entity",
"type": "progene_text",
"text": [
"RNA polymerase"
],
"offsets": [
[
113,
127
]
],
"normalized": []
},
{
"id": "split_0_train_9491_entity",
"type": "progene_text",
"text": [
"sigma factor"
],
"offsets": [
[
176,
188
]
],
"normalized": []
},
{
"id": "split_0_train_9492_entity",
"type": "progene_text",
"text": [
"sigmaE"
],
"offsets": [
[
189,
195
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6089
|
split_0_train_6089
|
[
{
"id": "split_0_train_6089_passage",
"type": "progene_text",
"text": [
"In addition to previously identified rpoE - dependent promoters , 11 new promoters potentially directing the expression of 15 genes were identified that were active only after over - expression of rpoE ."
],
"offsets": [
[
0,
203
]
]
}
] |
[
{
"id": "split_0_train_9493_entity",
"type": "progene_text",
"text": [
"rpoE"
],
"offsets": [
[
37,
41
]
],
"normalized": []
},
{
"id": "split_0_train_9494_entity",
"type": "progene_text",
"text": [
"rpoE"
],
"offsets": [
[
197,
201
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6090
|
split_0_train_6090
|
[
{
"id": "split_0_train_6090_passage",
"type": "progene_text",
"text": [
"The promoters were confirmed and transcriptional start points of the promoters were determined by primer extension analysis and S1 - nuclease mapping ."
],
"offsets": [
[
0,
151
]
]
}
] |
[
{
"id": "split_0_train_9495_entity",
"type": "progene_text",
"text": [
"S1 - nuclease"
],
"offsets": [
[
128,
141
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6091
|
split_0_train_6091
|
[
{
"id": "split_0_train_6091_passage",
"type": "progene_text",
"text": [
"All the promoters contained sequences similar to the consensus sequence of rpoE - dependent promoters ."
],
"offsets": [
[
0,
103
]
]
}
] |
[
{
"id": "split_0_train_9496_entity",
"type": "progene_text",
"text": [
"rpoE"
],
"offsets": [
[
75,
79
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6092
|
split_0_train_6092
|
[
{
"id": "split_0_train_6092_passage",
"type": "progene_text",
"text": [
"The new rpoE - dependent promoters governed expression of genes encoding proteins involved in primary metabolism ( fusA , tufA , recR ) , phospholipid and lipopolysaccharide biosynthesis ( psd , lpxP ) , signal transduction ( sixA ) , proposed inner or outer membrane proteins ( bacA , sbmA , smpA , yeaY ) , and proteins with unknown function ( ybaB , yaiW , yiiS , yiiT , yfeY ) ."
],
"offsets": [
[
0,
382
]
]
}
] |
[
{
"id": "split_0_train_9497_entity",
"type": "progene_text",
"text": [
"rpoE"
],
"offsets": [
[
8,
12
]
],
"normalized": []
},
{
"id": "split_0_train_9498_entity",
"type": "progene_text",
"text": [
"fusA"
],
"offsets": [
[
115,
119
]
],
"normalized": []
},
{
"id": "split_0_train_9499_entity",
"type": "progene_text",
"text": [
"tufA"
],
"offsets": [
[
122,
126
]
],
"normalized": []
},
{
"id": "split_0_train_9500_entity",
"type": "progene_text",
"text": [
"recR"
],
"offsets": [
[
129,
133
]
],
"normalized": []
},
{
"id": "split_0_train_9501_entity",
"type": "progene_text",
"text": [
"psd"
],
"offsets": [
[
189,
192
]
],
"normalized": []
},
{
"id": "split_0_train_9502_entity",
"type": "progene_text",
"text": [
"lpxP"
],
"offsets": [
[
195,
199
]
],
"normalized": []
},
{
"id": "split_0_train_9503_entity",
"type": "progene_text",
"text": [
"sixA"
],
"offsets": [
[
226,
230
]
],
"normalized": []
},
{
"id": "split_0_train_9504_entity",
"type": "progene_text",
"text": [
"bacA"
],
"offsets": [
[
279,
283
]
],
"normalized": []
},
{
"id": "split_0_train_9505_entity",
"type": "progene_text",
"text": [
"sbmA"
],
"offsets": [
[
286,
290
]
],
"normalized": []
},
{
"id": "split_0_train_9506_entity",
"type": "progene_text",
"text": [
"smpA"
],
"offsets": [
[
293,
297
]
],
"normalized": []
},
{
"id": "split_0_train_9507_entity",
"type": "progene_text",
"text": [
"yeaY"
],
"offsets": [
[
300,
304
]
],
"normalized": []
},
{
"id": "split_0_train_9508_entity",
"type": "progene_text",
"text": [
"ybaB"
],
"offsets": [
[
346,
350
]
],
"normalized": []
},
{
"id": "split_0_train_9509_entity",
"type": "progene_text",
"text": [
"yaiW"
],
"offsets": [
[
353,
357
]
],
"normalized": []
},
{
"id": "split_0_train_9510_entity",
"type": "progene_text",
"text": [
"yiiS"
],
"offsets": [
[
360,
364
]
],
"normalized": []
},
{
"id": "split_0_train_9511_entity",
"type": "progene_text",
"text": [
"yiiT"
],
"offsets": [
[
367,
371
]
],
"normalized": []
},
{
"id": "split_0_train_9512_entity",
"type": "progene_text",
"text": [
"yfeY"
],
"offsets": [
[
374,
378
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6093
|
split_0_train_6093
|
[
{
"id": "split_0_train_6093_passage",
"type": "progene_text",
"text": [
"A synthetic peptide from transforming growth factor beta type III receptor inhibits liver fibrogenesis in rats with carbon tetrachloride liver injury ."
],
"offsets": [
[
0,
151
]
]
}
] |
[
{
"id": "split_0_train_9513_entity",
"type": "progene_text",
"text": [
"transforming growth factor beta type III receptor"
],
"offsets": [
[
25,
74
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6094
|
split_0_train_6094
|
[
{
"id": "split_0_train_6094_passage",
"type": "progene_text",
"text": [
"Transforming growth factor beta1 ( TGF-beta1 ) is a pleiotropic cytokine , which displays potent profibrogenic effects and is highly expressed in fibrotic livers ."
],
"offsets": [
[
0,
163
]
]
}
] |
[
{
"id": "split_0_train_9514_entity",
"type": "progene_text",
"text": [
"Transforming growth factor beta1"
],
"offsets": [
[
0,
32
]
],
"normalized": []
},
{
"id": "split_0_train_9515_entity",
"type": "progene_text",
"text": [
"TGF-beta1"
],
"offsets": [
[
35,
44
]
],
"normalized": []
},
{
"id": "split_0_train_9516_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
64,
72
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6095
|
split_0_train_6095
|
[
{
"id": "split_0_train_6095_passage",
"type": "progene_text",
"text": [
"For this reason , development of TGF-B1 inhibitors might be of great importance to control liver fibrogenesis as well as other undesired side effects due to this cytokine ."
],
"offsets": [
[
0,
172
]
]
}
] |
[
{
"id": "split_0_train_9517_entity",
"type": "progene_text",
"text": [
"TGF-B1"
],
"offsets": [
[
33,
39
]
],
"normalized": []
},
{
"id": "split_0_train_9518_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
162,
170
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6096
|
split_0_train_6096
|
[
{
"id": "split_0_train_6096_passage",
"type": "progene_text",
"text": [
"Potential peptide inhibitors of TGF-beta1 ( derived from TGF-beta1 and from its type III receptor ) were tested in vitro and in vivo using different assays ."
],
"offsets": [
[
0,
157
]
]
}
] |
[
{
"id": "split_0_train_9519_entity",
"type": "progene_text",
"text": [
"TGF-beta1"
],
"offsets": [
[
32,
41
]
],
"normalized": []
},
{
"id": "split_0_train_9520_entity",
"type": "progene_text",
"text": [
"TGF-beta1"
],
"offsets": [
[
57,
66
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6097
|
split_0_train_6097
|
[
{
"id": "split_0_train_6097_passage",
"type": "progene_text",
"text": [
"Peptides P11 and P12 , derived from TGF-beta1 , and P54 and P144 , derived from its type III receptor , prevented TGF-beta1 - dependent inhibition of MV1Lu proliferation in vitro and markedly reduced binding of TGF-beta1 to its receptors ."
],
"offsets": [
[
0,
239
]
]
}
] |
[
{
"id": "split_0_train_9521_entity",
"type": "progene_text",
"text": [
"TGF-beta1"
],
"offsets": [
[
36,
45
]
],
"normalized": []
},
{
"id": "split_0_train_9522_entity",
"type": "progene_text",
"text": [
"TGF-beta1"
],
"offsets": [
[
114,
123
]
],
"normalized": []
},
{
"id": "split_0_train_9523_entity",
"type": "progene_text",
"text": [
"TGF-beta1"
],
"offsets": [
[
211,
220
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6098
|
split_0_train_6098
|
[
{
"id": "split_0_train_6098_passage",
"type": "progene_text",
"text": [
"P144 blocked TGF-beta1 - dependent stimulation of a reporter gene under the control of human alpha2(I) collagen promoter ."
],
"offsets": [
[
0,
122
]
]
}
] |
[
{
"id": "split_0_train_9524_entity",
"type": "progene_text",
"text": [
"TGF-beta1"
],
"offsets": [
[
13,
22
]
],
"normalized": []
},
{
"id": "split_0_train_9525_entity",
"type": "progene_text",
"text": [
"alpha2(I) collagen"
],
"offsets": [
[
93,
111
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6099
|
split_0_train_6099
|
[
{
"id": "split_0_train_6099_passage",
"type": "progene_text",
"text": [
"Intraperitoneal administration of P144 also showed potent antifibrogenic activity in vivo in the liver of rats receiving CCl4 ."
],
"offsets": [
[
0,
127
]
]
}
] |
[] |
[] |
[] |
[] |
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