id
stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
split_0_train_6100
|
split_0_train_6100
|
[
{
"id": "split_0_train_6100_passage",
"type": "progene_text",
"text": [
"These rats also showed a significant decrease in the number of activated hepatic stellate cells as compared with those treated with saline only ."
],
"offsets": [
[
0,
145
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6101
|
split_0_train_6101
|
[
{
"id": "split_0_train_6101_passage",
"type": "progene_text",
"text": [
"These results suggest that short synthetic peptides derived from TGF-beta1 type III receptor may be of value in reducing liver fibrosis in chronic liver injury ."
],
"offsets": [
[
0,
161
]
]
}
] |
[
{
"id": "split_0_train_9526_entity",
"type": "progene_text",
"text": [
"TGF-beta1 type III receptor"
],
"offsets": [
[
65,
92
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6102
|
split_0_train_6102
|
[
{
"id": "split_0_train_6102_passage",
"type": "progene_text",
"text": [
"Reduced sulfhydryls maintain specific incision of BPDE - DNA adducts by recombinant thermoresistant Bacillus caldotenax UvrABC endonuclease ."
],
"offsets": [
[
0,
141
]
]
}
] |
[
{
"id": "split_0_train_9527_entity",
"type": "progene_text",
"text": [
"UvrABC endonuclease"
],
"offsets": [
[
120,
139
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6103
|
split_0_train_6103
|
[
{
"id": "split_0_train_6103_passage",
"type": "progene_text",
"text": [
"Prokaryotic DNA repair nucleases are useful reagents for detecting DNA lesions ."
],
"offsets": [
[
0,
80
]
]
}
] |
[
{
"id": "split_0_train_9528_entity",
"type": "progene_text",
"text": [
"DNA repair nucleases"
],
"offsets": [
[
12,
32
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6104
|
split_0_train_6104
|
[
{
"id": "split_0_train_6104_passage",
"type": "progene_text",
"text": [
"Escherichia coli UvrABC endonuclease can incise DNA containing UV photoproducts and bulky chemical adducts ."
],
"offsets": [
[
0,
108
]
]
}
] |
[
{
"id": "split_0_train_9529_entity",
"type": "progene_text",
"text": [
"UvrABC endonuclease"
],
"offsets": [
[
17,
36
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6105
|
split_0_train_6105
|
[
{
"id": "split_0_train_6105_passage",
"type": "progene_text",
"text": [
"The limited stability of the E. coli UvrABC subunits leads to difficulty in estimating incision efficiency and quantitative adduct detection ."
],
"offsets": [
[
0,
142
]
]
}
] |
[
{
"id": "split_0_train_9530_entity",
"type": "progene_text",
"text": [
"UvrABC"
],
"offsets": [
[
37,
43
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6106
|
split_0_train_6106
|
[
{
"id": "split_0_train_6106_passage",
"type": "progene_text",
"text": [
"To develop a more stable enzyme with greater utility for the detection of DNA adducts , thermoresistant UvrABC endonuclease was cloned from the eubacterium Bacillus caldotenax ( Bca ) and individual recombinant protein subunits were overexpressed in and purified from E. coli ."
],
"offsets": [
[
0,
277
]
]
}
] |
[
{
"id": "split_0_train_9531_entity",
"type": "progene_text",
"text": [
"UvrABC endonuclease"
],
"offsets": [
[
104,
123
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6107
|
split_0_train_6107
|
[
{
"id": "split_0_train_6107_passage",
"type": "progene_text",
"text": [
"Here , we show that Bca UvrC that had lost activity or specificity could be restored by dialysis against buffer containing 500 mM KCl and 20mM dithiothreitol ."
],
"offsets": [
[
0,
159
]
]
}
] |
[
{
"id": "split_0_train_9532_entity",
"type": "progene_text",
"text": [
"UvrC"
],
"offsets": [
[
24,
28
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6108
|
split_0_train_6108
|
[
{
"id": "split_0_train_6108_passage",
"type": "progene_text",
"text": [
"Our data indicate that UvrC solubility depended on high salt concentrations and UvrC nuclease activity and the specificity of incisions depended on the presence of reduced sulfhydryls ."
],
"offsets": [
[
0,
185
]
]
}
] |
[
{
"id": "split_0_train_9533_entity",
"type": "progene_text",
"text": [
"UvrC"
],
"offsets": [
[
23,
27
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],
"normalized": []
},
{
"id": "split_0_train_9534_entity",
"type": "progene_text",
"text": [
"UvrC nuclease"
],
"offsets": [
[
80,
93
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6109
|
split_0_train_6109
|
[
{
"id": "split_0_train_6109_passage",
"type": "progene_text",
"text": [
"Optimal conditions for BCA UvrABC - specific cleavage of plasmid DNAs treated with [3H](+)-7R,8S-dihydroxy-9S,10R-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene ( BPDE ) ( 1 - 5 lesions / plasmid ) were developed ."
],
"offsets": [
[
0,
207
]
]
}
] |
[
{
"id": "split_0_train_9535_entity",
"type": "progene_text",
"text": [
"UvrABC"
],
"offsets": [
[
27,
33
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6110
|
split_0_train_6110
|
[
{
"id": "split_0_train_6110_passage",
"type": "progene_text",
"text": [
"Preincubation of substrates with UvrA and UvrB enhanced incision efficiency on damaged substrates and decreased non - specific nuclease activity on undamaged substrates ."
],
"offsets": [
[
0,
170
]
]
}
] |
[
{
"id": "split_0_train_9536_entity",
"type": "progene_text",
"text": [
"UvrA"
],
"offsets": [
[
33,
37
]
],
"normalized": []
},
{
"id": "split_0_train_9537_entity",
"type": "progene_text",
"text": [
"UvrB"
],
"offsets": [
[
42,
46
]
],
"normalized": []
},
{
"id": "split_0_train_9538_entity",
"type": "progene_text",
"text": [
"nuclease"
],
"offsets": [
[
127,
135
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6111
|
split_0_train_6111
|
[
{
"id": "split_0_train_6111_passage",
"type": "progene_text",
"text": [
"Under optimal conditions for damaged plasmid incision , approximately 70 % of adducts were incised in 1 nM plasmid DNA ( 2 BPDE adducts / 5.4 kbp plasmid ) with UvrA at 2.5 nM , UvrB at 62.5 nM , and UvrC at 25 nM ."
],
"offsets": [
[
0,
215
]
]
}
] |
[
{
"id": "split_0_train_9539_entity",
"type": "progene_text",
"text": [
"UvrA"
],
"offsets": [
[
161,
165
]
],
"normalized": []
},
{
"id": "split_0_train_9540_entity",
"type": "progene_text",
"text": [
"UvrB"
],
"offsets": [
[
178,
182
]
],
"normalized": []
},
{
"id": "split_0_train_9541_entity",
"type": "progene_text",
"text": [
"UvrC"
],
"offsets": [
[
200,
204
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6112
|
split_0_train_6112
|
[
{
"id": "split_0_train_6112_passage",
"type": "progene_text",
"text": [
"These results demonstrate the potential usefulness of the Bca UvrABC for monitoring the distribution of chemical carcinogen - induced lesions in DNA ."
],
"offsets": [
[
0,
150
]
]
}
] |
[
{
"id": "split_0_train_9542_entity",
"type": "progene_text",
"text": [
"UvrABC"
],
"offsets": [
[
62,
68
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6113
|
split_0_train_6113
|
[
{
"id": "split_0_train_6113_passage",
"type": "progene_text",
"text": [
"Control of enzyme IIscr and sucrose-6-phosphate hydrolase activities in Streptococcus mutans by transcriptional repressor ScrR binding to the cis - active determinants of the scr regulon ."
],
"offsets": [
[
0,
188
]
]
}
] |
[
{
"id": "split_0_train_9543_entity",
"type": "progene_text",
"text": [
"enzyme IIscr"
],
"offsets": [
[
11,
23
]
],
"normalized": []
},
{
"id": "split_0_train_9544_entity",
"type": "progene_text",
"text": [
"sucrose-6-phosphate hydrolase"
],
"offsets": [
[
28,
57
]
],
"normalized": []
},
{
"id": "split_0_train_9545_entity",
"type": "progene_text",
"text": [
"ScrR"
],
"offsets": [
[
122,
126
]
],
"normalized": []
},
{
"id": "split_0_train_9546_entity",
"type": "progene_text",
"text": [
"scr"
],
"offsets": [
[
175,
178
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6114
|
split_0_train_6114
|
[
{
"id": "split_0_train_6114_passage",
"type": "progene_text",
"text": [
"In Streptococcus mutans , enzyme II ( scr ) and sucrose-6-phosphate hydrolase are two important enzymes in the transport and metabolism of dietary sucrose ."
],
"offsets": [
[
0,
156
]
]
}
] |
[
{
"id": "split_0_train_9547_entity",
"type": "progene_text",
"text": [
"enzyme II ( scr )"
],
"offsets": [
[
26,
43
]
],
"normalized": []
},
{
"id": "split_0_train_9548_entity",
"type": "progene_text",
"text": [
"sucrose-6-phosphate hydrolase"
],
"offsets": [
[
48,
77
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6115
|
split_0_train_6115
|
[
{
"id": "split_0_train_6115_passage",
"type": "progene_text",
"text": [
"The scr regulon of S. mutans is composed of three genes , scrA and scrB , which code for enzyme II ( scr ) and sucrose - 6 - phosphate hydrolase , respectively , and scrR , which codes for a GalR - LacI - type transcription regulator ."
],
"offsets": [
[
0,
235
]
]
}
] |
[
{
"id": "split_0_train_9549_entity",
"type": "progene_text",
"text": [
"scr"
],
"offsets": [
[
4,
7
]
],
"normalized": []
},
{
"id": "split_0_train_9550_entity",
"type": "progene_text",
"text": [
"scrA"
],
"offsets": [
[
58,
62
]
],
"normalized": []
},
{
"id": "split_0_train_9551_entity",
"type": "progene_text",
"text": [
"scrB"
],
"offsets": [
[
67,
71
]
],
"normalized": []
},
{
"id": "split_0_train_9552_entity",
"type": "progene_text",
"text": [
"enzyme II ( scr )"
],
"offsets": [
[
89,
106
]
],
"normalized": []
},
{
"id": "split_0_train_9553_entity",
"type": "progene_text",
"text": [
"sucrose - 6 - phosphate hydrolase"
],
"offsets": [
[
111,
144
]
],
"normalized": []
},
{
"id": "split_0_train_9554_entity",
"type": "progene_text",
"text": [
"scrR"
],
"offsets": [
[
166,
170
]
],
"normalized": []
},
{
"id": "split_0_train_9555_entity",
"type": "progene_text",
"text": [
"GalR"
],
"offsets": [
[
191,
195
]
],
"normalized": []
},
{
"id": "split_0_train_9556_entity",
"type": "progene_text",
"text": [
"LacI"
],
"offsets": [
[
198,
202
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6116
|
split_0_train_6116
|
[
{
"id": "split_0_train_6116_passage",
"type": "progene_text",
"text": [
"It was previously shown that expression of both scrA and scrB is similarly induced by sucrose ."
],
"offsets": [
[
0,
95
]
]
}
] |
[
{
"id": "split_0_train_9557_entity",
"type": "progene_text",
"text": [
"scrA"
],
"offsets": [
[
48,
52
]
],
"normalized": []
},
{
"id": "split_0_train_9558_entity",
"type": "progene_text",
"text": [
"scrB"
],
"offsets": [
[
57,
61
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6117
|
split_0_train_6117
|
[
{
"id": "split_0_train_6117_passage",
"type": "progene_text",
"text": [
"Mutation in the scrR gene resulted in increased expression of scrB relative to that in the wild - type strain ."
],
"offsets": [
[
0,
111
]
]
}
] |
[
{
"id": "split_0_train_9559_entity",
"type": "progene_text",
"text": [
"scrR"
],
"offsets": [
[
16,
20
]
],
"normalized": []
},
{
"id": "split_0_train_9560_entity",
"type": "progene_text",
"text": [
"scrB"
],
"offsets": [
[
62,
66
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6118
|
split_0_train_6118
|
[
{
"id": "split_0_train_6118_passage",
"type": "progene_text",
"text": [
"In this study , we employed DNA mobility shift and DNase I protection assays with a purified ScrR - histidine tag fusion protein to examine the DNA binding properties of ScrR to the promoter regions of the scrA and scrB genes ."
],
"offsets": [
[
0,
227
]
]
}
] |
[
{
"id": "split_0_train_9561_entity",
"type": "progene_text",
"text": [
"DNase I"
],
"offsets": [
[
51,
58
]
],
"normalized": []
},
{
"id": "split_0_train_9562_entity",
"type": "progene_text",
"text": [
"ScrR"
],
"offsets": [
[
93,
97
]
],
"normalized": []
},
{
"id": "split_0_train_9563_entity",
"type": "progene_text",
"text": [
"ScrR"
],
"offsets": [
[
170,
174
]
],
"normalized": []
},
{
"id": "split_0_train_9564_entity",
"type": "progene_text",
"text": [
"scrA"
],
"offsets": [
[
206,
210
]
],
"normalized": []
},
{
"id": "split_0_train_9565_entity",
"type": "progene_text",
"text": [
"scrB"
],
"offsets": [
[
215,
219
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6119
|
split_0_train_6119
|
[
{
"id": "split_0_train_6119_passage",
"type": "progene_text",
"text": [
"The results showed that ScrR bound specifically to the promoter regions of both scrA and scrB ."
],
"offsets": [
[
0,
95
]
]
}
] |
[
{
"id": "split_0_train_9566_entity",
"type": "progene_text",
"text": [
"ScrR"
],
"offsets": [
[
24,
28
]
],
"normalized": []
},
{
"id": "split_0_train_9567_entity",
"type": "progene_text",
"text": [
"scrA"
],
"offsets": [
[
80,
84
]
],
"normalized": []
},
{
"id": "split_0_train_9568_entity",
"type": "progene_text",
"text": [
"scrB"
],
"offsets": [
[
89,
93
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6120
|
split_0_train_6120
|
[
{
"id": "split_0_train_6120_passage",
"type": "progene_text",
"text": [
"Two regions with high affinity for ScrR in the promoter sequences of the scrA and scrB genes were identified by DNase I protection assays ."
],
"offsets": [
[
0,
139
]
]
}
] |
[
{
"id": "split_0_train_9569_entity",
"type": "progene_text",
"text": [
"ScrR"
],
"offsets": [
[
35,
39
]
],
"normalized": []
},
{
"id": "split_0_train_9570_entity",
"type": "progene_text",
"text": [
"scrA"
],
"offsets": [
[
73,
77
]
],
"normalized": []
},
{
"id": "split_0_train_9571_entity",
"type": "progene_text",
"text": [
"scrB"
],
"offsets": [
[
82,
86
]
],
"normalized": []
},
{
"id": "split_0_train_9572_entity",
"type": "progene_text",
"text": [
"DNase I"
],
"offsets": [
[
112,
119
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6121
|
split_0_train_6121
|
[
{
"id": "split_0_train_6121_passage",
"type": "progene_text",
"text": [
"One , O(C) , which includes a 20 - bp imperfect inverted - repeat sequence , is located between the two promoters , and the other , O ( B ) , is located within the scrB promoter region containing a 37 - bp imperfect direct - repeat sequence ."
],
"offsets": [
[
0,
242
]
]
}
] |
[
{
"id": "split_0_train_9573_entity",
"type": "progene_text",
"text": [
"scrB"
],
"offsets": [
[
164,
168
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6122
|
split_0_train_6122
|
[
{
"id": "split_0_train_6122_passage",
"type": "progene_text",
"text": [
"Mutations of O(B) and O ( C ) resulted in constitutive transcription and expression of both the scrA and scrB genes ."
],
"offsets": [
[
0,
117
]
]
}
] |
[
{
"id": "split_0_train_9574_entity",
"type": "progene_text",
"text": [
"scrA"
],
"offsets": [
[
96,
100
]
],
"normalized": []
},
{
"id": "split_0_train_9575_entity",
"type": "progene_text",
"text": [
"scrB"
],
"offsets": [
[
105,
109
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6123
|
split_0_train_6123
|
[
{
"id": "split_0_train_6123_passage",
"type": "progene_text",
"text": [
"Our results indicated that S. mutans coordinates the activities of enzyme II(scr) and sucrose - 6 - phosphate hydrolase by transcriptional repressor ScrR binding to the promoter regions of the scr regulon ."
],
"offsets": [
[
0,
206
]
]
}
] |
[
{
"id": "split_0_train_9576_entity",
"type": "progene_text",
"text": [
"enzyme II(scr)"
],
"offsets": [
[
67,
81
]
],
"normalized": []
},
{
"id": "split_0_train_9577_entity",
"type": "progene_text",
"text": [
"sucrose - 6 - phosphate hydrolase"
],
"offsets": [
[
86,
119
]
],
"normalized": []
},
{
"id": "split_0_train_9578_entity",
"type": "progene_text",
"text": [
"ScrR"
],
"offsets": [
[
149,
153
]
],
"normalized": []
},
{
"id": "split_0_train_9579_entity",
"type": "progene_text",
"text": [
"scr"
],
"offsets": [
[
193,
196
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6124
|
split_0_train_6124
|
[
{
"id": "split_0_train_6124_passage",
"type": "progene_text",
"text": [
"Crystal structure of human platelet - derived growth factor BB ."
],
"offsets": [
[
0,
64
]
]
}
] |
[
{
"id": "split_0_train_9580_entity",
"type": "progene_text",
"text": [
"platelet - derived growth factor BB"
],
"offsets": [
[
27,
62
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6125
|
split_0_train_6125
|
[
{
"id": "split_0_train_6125_passage",
"type": "progene_text",
"text": [
"The crystal structure of the homodimeric BB isoform of human recombinant platelet - derived growth factor ( PDGF-BB ) has been determined by X - ray analysis to 3.0 A resolution ."
],
"offsets": [
[
0,
179
]
]
}
] |
[
{
"id": "split_0_train_9581_entity",
"type": "progene_text",
"text": [
"platelet - derived growth factor"
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"offsets": [
[
73,
105
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],
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},
{
"id": "split_0_train_9582_entity",
"type": "progene_text",
"text": [
"PDGF-BB"
],
"offsets": [
[
108,
115
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6126
|
split_0_train_6126
|
[
{
"id": "split_0_train_6126_passage",
"type": "progene_text",
"text": [
"The polypeptide chain is folded into two highly twisted antiparallel pairs of beta-strands and contains an unusual knotted arrangement of three intramolecular disulfide bonds ."
],
"offsets": [
[
0,
176
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6127
|
split_0_train_6127
|
[
{
"id": "split_0_train_6127_passage",
"type": "progene_text",
"text": [
"Dimerization leads to the clustering of three surface loops at each end of the elongated dimer , which most probably form the receptor recognition sites ."
],
"offsets": [
[
0,
154
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6128
|
split_0_train_6128
|
[
{
"id": "split_0_train_6128_passage",
"type": "progene_text",
"text": [
"Analysis of the alternative oxidase promoters from soybean ."
],
"offsets": [
[
0,
60
]
]
}
] |
[
{
"id": "split_0_train_9583_entity",
"type": "progene_text",
"text": [
"alternative oxidase"
],
"offsets": [
[
16,
35
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6129
|
split_0_train_6129
|
[
{
"id": "split_0_train_6129_passage",
"type": "progene_text",
"text": [
"Alternative oxidase ( Aox ) is a nuclear - encoded mitochondrial protein ."
],
"offsets": [
[
0,
74
]
]
}
] |
[
{
"id": "split_0_train_9584_entity",
"type": "progene_text",
"text": [
"Alternative oxidase"
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"offsets": [
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0,
19
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},
{
"id": "split_0_train_9585_entity",
"type": "progene_text",
"text": [
"Aox"
],
"offsets": [
[
22,
25
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6130
|
split_0_train_6130
|
[
{
"id": "split_0_train_6130_passage",
"type": "progene_text",
"text": [
"In soybean ( Glycine max ) , the three members of the gene family have been shown to be differentially expressed during normal plant development and in response to stresses ."
],
"offsets": [
[
0,
174
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6131
|
split_0_train_6131
|
[
{
"id": "split_0_train_6131_passage",
"type": "progene_text",
"text": [
"To examine the function of the Aox promoters , genomic fragments were obtained for all three soybean genes : Aox1 , Aox2a , and Aox2b ."
],
"offsets": [
[
0,
135
]
]
}
] |
[
{
"id": "split_0_train_9586_entity",
"type": "progene_text",
"text": [
"Aox"
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31,
34
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{
"id": "split_0_train_9587_entity",
"type": "progene_text",
"text": [
"Aox1"
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109,
113
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},
{
"id": "split_0_train_9588_entity",
"type": "progene_text",
"text": [
"Aox2a"
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116,
121
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"normalized": []
},
{
"id": "split_0_train_9589_entity",
"type": "progene_text",
"text": [
"Aox2b"
],
"offsets": [
[
128,
133
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6132
|
split_0_train_6132
|
[
{
"id": "split_0_train_6132_passage",
"type": "progene_text",
"text": [
"The regions of these fragments immediately upstream of the coding regions were used to drive beta-glucuronidase ( GUS ) expression during transient transformation of soybean suspension culture cells and stable transformation of Arabidopsis ."
],
"offsets": [
[
0,
241
]
]
}
] |
[
{
"id": "split_0_train_9590_entity",
"type": "progene_text",
"text": [
"beta-glucuronidase"
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[
93,
111
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],
"normalized": []
},
{
"id": "split_0_train_9591_entity",
"type": "progene_text",
"text": [
"GUS"
],
"offsets": [
[
114,
117
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6133
|
split_0_train_6133
|
[
{
"id": "split_0_train_6133_passage",
"type": "progene_text",
"text": [
"The expression patterns of the GUS reporter genes in soybean cells were in agreement with the presence or absence of the various endogenous Aox proteins , determined by immunoblotting ."
],
"offsets": [
[
0,
185
]
]
}
] |
[
{
"id": "split_0_train_9592_entity",
"type": "progene_text",
"text": [
"GUS"
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[
31,
34
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},
{
"id": "split_0_train_9593_entity",
"type": "progene_text",
"text": [
"Aox"
],
"offsets": [
[
140,
143
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6134
|
split_0_train_6134
|
[
{
"id": "split_0_train_6134_passage",
"type": "progene_text",
"text": [
"Deletion of different portions of the upstream regions identified sequences responsible for both positive and negative regulation of Aox gene expression in soybean cells ."
],
"offsets": [
[
0,
171
]
]
}
] |
[
{
"id": "split_0_train_9594_entity",
"type": "progene_text",
"text": [
"Aox"
],
"offsets": [
[
133,
136
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6135
|
split_0_train_6135
|
[
{
"id": "split_0_train_6135_passage",
"type": "progene_text",
"text": [
"Reporter gene analysis in Arabidopsis plants showed differential tissue expression patterns driven by the three upstream regions , similar to those reported for the endogenous proteins in soybean ."
],
"offsets": [
[
0,
197
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6136
|
split_0_train_6136
|
[
{
"id": "split_0_train_6136_passage",
"type": "progene_text",
"text": [
"The expression profiles of all five members of the Arabidopsis Aox gene family were examined also , to compare with GUS expression driven by the soybean upstream fragments ."
],
"offsets": [
[
0,
173
]
]
}
] |
[
{
"id": "split_0_train_9595_entity",
"type": "progene_text",
"text": [
"Aox gene family"
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"offsets": [
[
63,
78
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],
"normalized": []
},
{
"id": "split_0_train_9596_entity",
"type": "progene_text",
"text": [
"GUS"
],
"offsets": [
[
116,
119
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6137
|
split_0_train_6137
|
[
{
"id": "split_0_train_6137_passage",
"type": "progene_text",
"text": [
"Even though the promoter activity of the upstream fragments from soybean Aox2a and Aox2b displayed the same tissue specificity in Arabidopsis as they do in soybean , the most prominently expressed endogenous genes in all tissues of Arabidopsis were of the Aox1 type ."
],
"offsets": [
[
0,
267
]
]
}
] |
[
{
"id": "split_0_train_9597_entity",
"type": "progene_text",
"text": [
"Aox2a"
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"offsets": [
[
73,
78
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],
"normalized": []
},
{
"id": "split_0_train_9598_entity",
"type": "progene_text",
"text": [
"Aox2b"
],
"offsets": [
[
83,
88
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],
"normalized": []
},
{
"id": "split_0_train_9599_entity",
"type": "progene_text",
"text": [
"Aox1"
],
"offsets": [
[
256,
260
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6138
|
split_0_train_6138
|
[
{
"id": "split_0_train_6138_passage",
"type": "progene_text",
"text": [
"Thus although regulation of Aox expression generally appears to involve the same signals in different species , different orthologs of Aox may respond variously to these signals ."
],
"offsets": [
[
0,
179
]
]
}
] |
[
{
"id": "split_0_train_9600_entity",
"type": "progene_text",
"text": [
"Aox"
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"offsets": [
[
28,
31
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],
"normalized": []
},
{
"id": "split_0_train_9601_entity",
"type": "progene_text",
"text": [
"Aox"
],
"offsets": [
[
135,
138
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6139
|
split_0_train_6139
|
[
{
"id": "split_0_train_6139_passage",
"type": "progene_text",
"text": [
"A comparison of upstream sequences between soybean Aox genes and similarly expressed Arabidopsis Aox genes identified common motifs ."
],
"offsets": [
[
0,
133
]
]
}
] |
[
{
"id": "split_0_train_9602_entity",
"type": "progene_text",
"text": [
"Aox"
],
"offsets": [
[
51,
54
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],
"normalized": []
},
{
"id": "split_0_train_9603_entity",
"type": "progene_text",
"text": [
"Aox"
],
"offsets": [
[
97,
100
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6140
|
split_0_train_6140
|
[
{
"id": "split_0_train_6140_passage",
"type": "progene_text",
"text": [
"Distribution of antinociceptive adenosine A1 receptors in the spinal cord dorsal horn , and relationship to primary afferents and neuronal subpopulations ."
],
"offsets": [
[
0,
155
]
]
}
] |
[
{
"id": "split_0_train_9604_entity",
"type": "progene_text",
"text": [
"adenosine A1 receptors"
],
"offsets": [
[
32,
54
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6141
|
split_0_train_6141
|
[
{
"id": "split_0_train_6141_passage",
"type": "progene_text",
"text": [
"Adenosine can reduce pain and allodynia in animals and man , probably via spinal adenosine A1 receptors ."
],
"offsets": [
[
0,
105
]
]
}
] |
[
{
"id": "split_0_train_9605_entity",
"type": "progene_text",
"text": [
"adenosine A1 receptors"
],
"offsets": [
[
81,
103
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6142
|
split_0_train_6142
|
[
{
"id": "split_0_train_6142_passage",
"type": "progene_text",
"text": [
"In the present study , we investigate the distribution of the adenosine A1 receptor in the rat spinal cord dorsal horn using immunohistochemistry , in situ hybridization , radioligand binding , and confocal microscopy ."
],
"offsets": [
[
0,
219
]
]
}
] |
[
{
"id": "split_0_train_9606_entity",
"type": "progene_text",
"text": [
"adenosine A1 receptor"
],
"offsets": [
[
62,
83
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6143
|
split_0_train_6143
|
[
{
"id": "split_0_train_6143_passage",
"type": "progene_text",
"text": [
"In the lumbar cord dorsal horn , dense immunoreactivity was seen in the inner part of lamina II ."
],
"offsets": [
[
0,
97
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6144
|
split_0_train_6144
|
[
{
"id": "split_0_train_6144_passage",
"type": "progene_text",
"text": [
"This was unaltered by dorsal root section or thoracic cord hemisection ."
],
"offsets": [
[
0,
72
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6145
|
split_0_train_6145
|
[
{
"id": "split_0_train_6145_passage",
"type": "progene_text",
"text": [
"Confocal microscopy of the dorsal horn revealed close anatomical relationships but no or only minor overlap between A1 receptors and immunoreactivity for markers associated with primary afferent central endings : calcitonin gene - related peptide , or isolectin B4 , or with neuronal subpopulations : mu - opioid receptor , neuronal nitric oxide synthase , met-enkephalin , parvalbumin , or protein kinase Cgamma , or with glial cells : glial fibrillary acidic protein ."
],
"offsets": [
[
0,
470
]
]
}
] |
[
{
"id": "split_0_train_9607_entity",
"type": "progene_text",
"text": [
"A1 receptors"
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"offsets": [
[
116,
128
]
],
"normalized": []
},
{
"id": "split_0_train_9608_entity",
"type": "progene_text",
"text": [
"calcitonin gene - related peptide"
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"offsets": [
[
213,
246
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],
"normalized": []
},
{
"id": "split_0_train_9609_entity",
"type": "progene_text",
"text": [
"isolectin B4"
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"offsets": [
[
252,
264
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],
"normalized": []
},
{
"id": "split_0_train_9610_entity",
"type": "progene_text",
"text": [
"mu - opioid receptor"
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"offsets": [
[
301,
321
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],
"normalized": []
},
{
"id": "split_0_train_9611_entity",
"type": "progene_text",
"text": [
"neuronal nitric oxide synthase"
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"offsets": [
[
324,
354
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],
"normalized": []
},
{
"id": "split_0_train_9612_entity",
"type": "progene_text",
"text": [
"met-enkephalin"
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"offsets": [
[
357,
371
]
],
"normalized": []
},
{
"id": "split_0_train_9613_entity",
"type": "progene_text",
"text": [
"parvalbumin"
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"offsets": [
[
374,
385
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],
"normalized": []
},
{
"id": "split_0_train_9614_entity",
"type": "progene_text",
"text": [
"protein kinase Cgamma"
],
"offsets": [
[
391,
412
]
],
"normalized": []
},
{
"id": "split_0_train_9615_entity",
"type": "progene_text",
"text": [
"glial fibrillary acidic protein"
],
"offsets": [
[
437,
468
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6146
|
split_0_train_6146
|
[
{
"id": "split_0_train_6146_passage",
"type": "progene_text",
"text": [
"A few adenosine A1 receptor positive structures were double - labeled with alpha-amino-3-hydroxy-5-methyl-4-isoaxolepropionic acid glutamate receptor subunits 1 and 2 / 3 ."
],
"offsets": [
[
0,
172
]
]
}
] |
[
{
"id": "split_0_train_9616_entity",
"type": "progene_text",
"text": [
"adenosine A1 receptor"
],
"offsets": [
[
6,
27
]
],
"normalized": []
},
{
"id": "split_0_train_9617_entity",
"type": "progene_text",
"text": [
"glutamate receptor subunits 1 and 2 / 3"
],
"offsets": [
[
131,
170
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6147
|
split_0_train_6147
|
[
{
"id": "split_0_train_6147_passage",
"type": "progene_text",
"text": [
"The results indicate that most of the adenosine A1 receptors in the dorsal horn are located in inner lamina II postsynaptic neuronal cell bodies and processes whose functional and neurochemical identity is so far unknown ."
],
"offsets": [
[
0,
222
]
]
}
] |
[
{
"id": "split_0_train_9618_entity",
"type": "progene_text",
"text": [
"adenosine A1 receptors"
],
"offsets": [
[
38,
60
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6148
|
split_0_train_6148
|
[
{
"id": "split_0_train_6148_passage",
"type": "progene_text",
"text": [
"Many adenosine A1 receptor positive structures are in close contact with isolectin B4 positive C - fiber primary afferents and/or postsynaptic structures containing components of importance for the modulation of nociceptive information ."
],
"offsets": [
[
0,
237
]
]
}
] |
[
{
"id": "split_0_train_9619_entity",
"type": "progene_text",
"text": [
"adenosine A1 receptor"
],
"offsets": [
[
5,
26
]
],
"normalized": []
},
{
"id": "split_0_train_9620_entity",
"type": "progene_text",
"text": [
"isolectin B4"
],
"offsets": [
[
73,
85
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6149
|
split_0_train_6149
|
[
{
"id": "split_0_train_6149_passage",
"type": "progene_text",
"text": [
"Cloning , sequencing , and expression of the fadD gene of Escherichia coli encoding acyl coenzyme A synthetase ."
],
"offsets": [
[
0,
112
]
]
}
] |
[
{
"id": "split_0_train_9621_entity",
"type": "progene_text",
"text": [
"fadD"
],
"offsets": [
[
45,
49
]
],
"normalized": []
},
{
"id": "split_0_train_9622_entity",
"type": "progene_text",
"text": [
"acyl coenzyme A synthetase"
],
"offsets": [
[
84,
110
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6150
|
split_0_train_6150
|
[
{
"id": "split_0_train_6150_passage",
"type": "progene_text",
"text": [
"In the enteric bacterium , Escherichia coli , acyl coenzyme A synthetase ( fatty acid : CoA ligase ( AMP-forming ) EC 6.2.1.3 ) activates exogenous long - chain fatty acids concomitant with their transport across the inner membrane into metabolically active CoA thioesters ."
],
"offsets": [
[
0,
274
]
]
}
] |
[
{
"id": "split_0_train_9623_entity",
"type": "progene_text",
"text": [
"acyl coenzyme A synthetase"
],
"offsets": [
[
46,
72
]
],
"normalized": []
},
{
"id": "split_0_train_9624_entity",
"type": "progene_text",
"text": [
"fatty acid : CoA ligase"
],
"offsets": [
[
75,
98
]
],
"normalized": []
},
{
"id": "split_0_train_9625_entity",
"type": "progene_text",
"text": [
"EC 6.2.1.3"
],
"offsets": [
[
115,
125
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6151
|
split_0_train_6151
|
[
{
"id": "split_0_train_6151_passage",
"type": "progene_text",
"text": [
"These compounds serve as substrates for acyl-CoA dehydrogenase in the first step in the process of beta-oxidation ."
],
"offsets": [
[
0,
115
]
]
}
] |
[
{
"id": "split_0_train_9626_entity",
"type": "progene_text",
"text": [
"acyl-CoA dehydrogenase"
],
"offsets": [
[
40,
62
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6152
|
split_0_train_6152
|
[
{
"id": "split_0_train_6152_passage",
"type": "progene_text",
"text": [
"The acyl-CoA synthetase structural gene , fadD , has been identified on clone 6D1 of the Kohara E. coli gene library and by a process of subcloning and complementation analyses shown to be contained on a 2.2 - kilobase NcoI - ClaI fragment of genomic DNA ."
],
"offsets": [
[
0,
256
]
]
}
] |
[
{
"id": "split_0_train_9627_entity",
"type": "progene_text",
"text": [
"acyl-CoA synthetase"
],
"offsets": [
[
4,
23
]
],
"normalized": []
},
{
"id": "split_0_train_9628_entity",
"type": "progene_text",
"text": [
"fadD"
],
"offsets": [
[
42,
46
]
],
"normalized": []
},
{
"id": "split_0_train_9629_entity",
"type": "progene_text",
"text": [
"NcoI"
],
"offsets": [
[
219,
223
]
],
"normalized": []
},
{
"id": "split_0_train_9630_entity",
"type": "progene_text",
"text": [
"ClaI"
],
"offsets": [
[
226,
230
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6153
|
split_0_train_6153
|
[
{
"id": "split_0_train_6153_passage",
"type": "progene_text",
"text": [
"The polypeptide encoded within this DNA fragment was identified following T7 RNA polymerase - dependent induction and estimated to be M(r) = 62,000 using SDS-polyacrylamide gel electrophoresis ."
],
"offsets": [
[
0,
194
]
]
}
] |
[
{
"id": "split_0_train_9631_entity",
"type": "progene_text",
"text": [
"T7 RNA polymerase"
],
"offsets": [
[
74,
91
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6154
|
split_0_train_6154
|
[
{
"id": "split_0_train_6154_passage",
"type": "progene_text",
"text": [
"The N - terminal amino acid sequence of acyl-CoA synthetase was determined by automated sequencing to be Met-Lys-Lys-Val-Trp-Leu-Asn-Arg-Tyr-Pro ."
],
"offsets": [
[
0,
146
]
]
}
] |
[
{
"id": "split_0_train_9632_entity",
"type": "progene_text",
"text": [
"acyl-CoA synthetase"
],
"offsets": [
[
40,
59
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6155
|
split_0_train_6155
|
[
{
"id": "split_0_train_6155_passage",
"type": "progene_text",
"text": [
"Sequence analysis of the 2.2 - kilobase NcoI - ClaI fragment revealed a single open reading frame encoding these amino acids as the first 10 residues of a protein with a molecular weight of 62,028 ."
],
"offsets": [
[
0,
198
]
]
}
] |
[
{
"id": "split_0_train_9633_entity",
"type": "progene_text",
"text": [
"NcoI"
],
"offsets": [
[
40,
44
]
],
"normalized": []
},
{
"id": "split_0_train_9634_entity",
"type": "progene_text",
"text": [
"ClaI"
],
"offsets": [
[
47,
51
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6156
|
split_0_train_6156
|
[
{
"id": "split_0_train_6156_passage",
"type": "progene_text",
"text": [
"The initiation codon for methionine was TTG ."
],
"offsets": [
[
0,
45
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6157
|
split_0_train_6157
|
[
{
"id": "split_0_train_6157_passage",
"type": "progene_text",
"text": [
"Primer extension of total in vivo mRNA from two fadD - specific oligonucleotides defined the transcriptional start at an adenine residue 60 base pairs upstream from the predicted translational start site ."
],
"offsets": [
[
0,
205
]
]
}
] |
[
{
"id": "split_0_train_9635_entity",
"type": "progene_text",
"text": [
"fadD"
],
"offsets": [
[
48,
52
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6158
|
split_0_train_6158
|
[
{
"id": "split_0_train_6158_passage",
"type": "progene_text",
"text": [
"Two FadR operator sites of the fadD gene were identified at positions - 13 to - 29 ( OD1 ) and positions - 99 to - 115 ( OD2 ) by DNase I footprinting ."
],
"offsets": [
[
0,
152
]
]
}
] |
[
{
"id": "split_0_train_9636_entity",
"type": "progene_text",
"text": [
"FadR"
],
"offsets": [
[
4,
8
]
],
"normalized": []
},
{
"id": "split_0_train_9637_entity",
"type": "progene_text",
"text": [
"fadD"
],
"offsets": [
[
31,
35
]
],
"normalized": []
},
{
"id": "split_0_train_9638_entity",
"type": "progene_text",
"text": [
"DNase I"
],
"offsets": [
[
130,
137
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6159
|
split_0_train_6159
|
[
{
"id": "split_0_train_6159_passage",
"type": "progene_text",
"text": [
"Comparisons of the predicted amino acid sequence of the E. coli acyl-CoA synthetase to the deduced amino acid sequences of the rat and yeast acyl-CoA synthetases and the firefly luciferase demonstrated that these enzymes shared a significant degree of similarity ."
],
"offsets": [
[
0,
264
]
]
}
] |
[
{
"id": "split_0_train_9639_entity",
"type": "progene_text",
"text": [
"acyl-CoA synthetase"
],
"offsets": [
[
64,
83
]
],
"normalized": []
},
{
"id": "split_0_train_9640_entity",
"type": "progene_text",
"text": [
"acyl-CoA synthetases"
],
"offsets": [
[
141,
161
]
],
"normalized": []
},
{
"id": "split_0_train_9641_entity",
"type": "progene_text",
"text": [
"luciferase"
],
"offsets": [
[
178,
188
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6160
|
split_0_train_6160
|
[
{
"id": "split_0_train_6160_passage",
"type": "progene_text",
"text": [
"Based on the similar reaction mechanisms of these four enzymes , this similarity may define a region required for the same function ."
],
"offsets": [
[
0,
133
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6161
|
split_0_train_6161
|
[
{
"id": "split_0_train_6161_passage",
"type": "progene_text",
"text": [
"Conserved structural elements in glutathione transferase homologues encoded in the genome of Escherichia coli ."
],
"offsets": [
[
0,
111
]
]
}
] |
[
{
"id": "split_0_train_9642_entity",
"type": "progene_text",
"text": [
"glutathione transferase"
],
"offsets": [
[
33,
56
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6162
|
split_0_train_6162
|
[
{
"id": "split_0_train_6162_passage",
"type": "progene_text",
"text": [
"Multiple sequence alignments of the eight glutathione ( GSH ) transferase homologues encoded in the genome of Escherichia coli were used to define a consensus sequence for the proteins ."
],
"offsets": [
[
0,
186
]
]
}
] |
[
{
"id": "split_0_train_9643_entity",
"type": "progene_text",
"text": [
"glutathione ( GSH ) transferase"
],
"offsets": [
[
42,
73
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6163
|
split_0_train_6163
|
[
{
"id": "split_0_train_6163_passage",
"type": "progene_text",
"text": [
"The consensus sequence was analyzed in the context of the three - dimensional structure of the gst gene product ( EGST ) obtained from two different crystal forms of the enzyme ."
],
"offsets": [
[
0,
178
]
]
}
] |
[
{
"id": "split_0_train_9644_entity",
"type": "progene_text",
"text": [
"gst"
],
"offsets": [
[
95,
98
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6164
|
split_0_train_6164
|
[
{
"id": "split_0_train_6164_passage",
"type": "progene_text",
"text": [
"The enzyme consists of two domains ."
],
"offsets": [
[
0,
36
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6165
|
split_0_train_6165
|
[
{
"id": "split_0_train_6165_passage",
"type": "progene_text",
"text": [
"The N - terminal region ( domain I ) has a thioredoxin - like alpha / beta - fold , while the C - terminal domain ( domain II ) is all alpha - helical ."
],
"offsets": [
[
0,
152
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6166
|
split_0_train_6166
|
[
{
"id": "split_0_train_6166_passage",
"type": "progene_text",
"text": [
"The majority of the consensus residues ( 12 / 17 ) reside in the N - terminal domain ."
],
"offsets": [
[
0,
86
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6167
|
split_0_train_6167
|
[
{
"id": "split_0_train_6167_passage",
"type": "progene_text",
"text": [
"Fifteen of the 17 residues are involved in hydrophobic core interactions , turns , or electrostatic interactions between the two domains ."
],
"offsets": [
[
0,
138
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6168
|
split_0_train_6168
|
[
{
"id": "split_0_train_6168_passage",
"type": "progene_text",
"text": [
"The results suggest that all of the homologues retain a well - defined group of structural elements both in and between the N - terminal alpha / beta domain and the C - terminal domain ."
],
"offsets": [
[
0,
186
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6169
|
split_0_train_6169
|
[
{
"id": "split_0_train_6169_passage",
"type": "progene_text",
"text": [
"The conservation of two key residues for the recognition motif for the gamma - glutamyl - portion of GSH indicates that the homologues may interact with GSH or GSH analogues such as glutathionylspermidine or alpha - amino acids ."
],
"offsets": [
[
0,
229
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6170
|
split_0_train_6170
|
[
{
"id": "split_0_train_6170_passage",
"type": "progene_text",
"text": [
"The genome context of two of the homologues forms the basis for a hypothesis that the b2989 and yibF gene products are involved in glutathionylspermidine and selenium biochemistry , respectively ."
],
"offsets": [
[
0,
196
]
]
}
] |
[
{
"id": "split_0_train_9645_entity",
"type": "progene_text",
"text": [
"b2989"
],
"offsets": [
[
86,
91
]
],
"normalized": []
},
{
"id": "split_0_train_9646_entity",
"type": "progene_text",
"text": [
"yibF"
],
"offsets": [
[
96,
100
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6171
|
split_0_train_6171
|
[
{
"id": "split_0_train_6171_passage",
"type": "progene_text",
"text": [
"Characterization and modulation of sex steroid metabolizing activity in normal human keratinocytes in primary culture and HaCaT cells ."
],
"offsets": [
[
0,
135
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6172
|
split_0_train_6172
|
[
{
"id": "split_0_train_6172_passage",
"type": "progene_text",
"text": [
"Skin , the largest organ of the human body , synthesizes active sex steroids from adrenal C19 precursor steroids ."
],
"offsets": [
[
0,
114
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6173
|
split_0_train_6173
|
[
{
"id": "split_0_train_6173_passage",
"type": "progene_text",
"text": [
"Normal human breast epidermal keratinocytes in primary culture were used to evaluate the enzymatic activities responsible for the formation and degradation of active androgens and estrogens during keratinocyte differentiation ."
],
"offsets": [
[
0,
227
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6174
|
split_0_train_6174
|
[
{
"id": "split_0_train_6174_passage",
"type": "progene_text",
"text": [
"Enzymatic activities , including 3beta-hydroxysteroid dehydrogenase / Delta5 - Delta4 isomerase ( 3beta-HSD ) , 17beta-hydroxysteroid dehydrogenase ( 17beta-HSD ) , 5alpha-reductase and 3alpha-hydroxysteroid dehydrogenase ( 3alpha-HSD ) were measured using [3H] steroids as substrates ."
],
"offsets": [
[
0,
286
]
]
}
] |
[
{
"id": "split_0_train_9647_entity",
"type": "progene_text",
"text": [
"3beta-hydroxysteroid dehydrogenase / Delta5 - Delta4 isomerase"
],
"offsets": [
[
33,
95
]
],
"normalized": []
},
{
"id": "split_0_train_9648_entity",
"type": "progene_text",
"text": [
"3beta-HSD"
],
"offsets": [
[
98,
107
]
],
"normalized": []
},
{
"id": "split_0_train_9649_entity",
"type": "progene_text",
"text": [
"17beta-hydroxysteroid dehydrogenase"
],
"offsets": [
[
112,
147
]
],
"normalized": []
},
{
"id": "split_0_train_9650_entity",
"type": "progene_text",
"text": [
"17beta-HSD"
],
"offsets": [
[
150,
160
]
],
"normalized": []
},
{
"id": "split_0_train_9651_entity",
"type": "progene_text",
"text": [
"5alpha-reductase"
],
"offsets": [
[
165,
181
]
],
"normalized": []
},
{
"id": "split_0_train_9652_entity",
"type": "progene_text",
"text": [
"3alpha-hydroxysteroid dehydrogenase"
],
"offsets": [
[
186,
221
]
],
"normalized": []
},
{
"id": "split_0_train_9653_entity",
"type": "progene_text",
"text": [
"3alpha-HSD"
],
"offsets": [
[
224,
234
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6175
|
split_0_train_6175
|
[
{
"id": "split_0_train_6175_passage",
"type": "progene_text",
"text": [
"After 10 - 60 days in culture , no 3beta-HSD activity was detected , but all other activities were measured , demonstrating the ability of keratinocytes to convert androstenedione ( 4-DIONE ) into the potent androgen dihydrotestosterone ( DHT ) ."
],
"offsets": [
[
0,
246
]
]
}
] |
[
{
"id": "split_0_train_9654_entity",
"type": "progene_text",
"text": [
"3beta-HSD"
],
"offsets": [
[
35,
44
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6176
|
split_0_train_6176
|
[
{
"id": "split_0_train_6176_passage",
"type": "progene_text",
"text": [
"Furthermore , marked changes in enzymatic activity were observed during cell differentiation : 17beta-HSD was first detected during the third week of culture , the level of activity reaching a peak during the fourth week ."
],
"offsets": [
[
0,
222
]
]
}
] |
[
{
"id": "split_0_train_9655_entity",
"type": "progene_text",
"text": [
"17beta-HSD"
],
"offsets": [
[
95,
105
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6177
|
split_0_train_6177
|
[
{
"id": "split_0_train_6177_passage",
"type": "progene_text",
"text": [
"This peak was followed by a progressive decrease during keratinization ."
],
"offsets": [
[
0,
72
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6178
|
split_0_train_6178
|
[
{
"id": "split_0_train_6178_passage",
"type": "progene_text",
"text": [
"On the other hand , 5alpha - reductase and 3alpha-HSD activities were first detected during the fourth week of culture ."
],
"offsets": [
[
0,
120
]
]
}
] |
[
{
"id": "split_0_train_9656_entity",
"type": "progene_text",
"text": [
"5alpha - reductase"
],
"offsets": [
[
20,
38
]
],
"normalized": []
},
{
"id": "split_0_train_9657_entity",
"type": "progene_text",
"text": [
"3alpha-HSD"
],
"offsets": [
[
43,
53
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6179
|
split_0_train_6179
|
[
{
"id": "split_0_train_6179_passage",
"type": "progene_text",
"text": [
"The enzymatic activities involved in the formation and degradation of sex steroids were also characterized in the immortalized human keratinocyte cell line HaCaT ."
],
"offsets": [
[
0,
163
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6180
|
split_0_train_6180
|
[
{
"id": "split_0_train_6180_passage",
"type": "progene_text",
"text": [
"It was then found that HaCaT cells possess a pattern of steroid metabolizing enzymes similar to that of human epidermal keratinocytes in culture ."
],
"offsets": [
[
0,
146
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6181
|
split_0_train_6181
|
[
{
"id": "split_0_train_6181_passage",
"type": "progene_text",
"text": [
"Since glucocorticoids are known to exert potent pharmacological effects on the skin , the effect of dexamethasone ( DEX ) on cell proliferation and enzymatic activities was determined using HaCaT cells ."
],
"offsets": [
[
0,
203
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6182
|
split_0_train_6182
|
[
{
"id": "split_0_train_6182_passage",
"type": "progene_text",
"text": [
"DEX causes a 55 % decrease in HaCaT cell proliferation ( IC50 : 10nM ) whereas DEX caused a three - to five - fold stimulation of oxidative 17beta-HSD activity in intact cells in culture ( ED50 : 30 nM ) and this stimulatory effect was competitively blocked by the glucocorticoid antagonist RU486 ."
],
"offsets": [
[
0,
298
]
]
}
] |
[
{
"id": "split_0_train_9658_entity",
"type": "progene_text",
"text": [
"17beta-HSD"
],
"offsets": [
[
140,
150
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6183
|
split_0_train_6183
|
[
{
"id": "split_0_train_6183_passage",
"type": "progene_text",
"text": [
"A four - fold increase in type 2 17beta-HSD mRNA levels was also observed as measured by real - time PCR , correlating with the increase in oxidative activity ."
],
"offsets": [
[
0,
160
]
]
}
] |
[
{
"id": "split_0_train_9659_entity",
"type": "progene_text",
"text": [
"type 2 17beta-HSD"
],
"offsets": [
[
26,
43
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6184
|
split_0_train_6184
|
[
{
"id": "split_0_train_6184_passage",
"type": "progene_text",
"text": [
"No effect of DEX on the other enzymatic activities ( 3beta-HSD , 5alpha-reductase , and 3alpha-HSD ) was observed ."
],
"offsets": [
[
0,
115
]
]
}
] |
[
{
"id": "split_0_train_9660_entity",
"type": "progene_text",
"text": [
"3beta-HSD"
],
"offsets": [
[
53,
62
]
],
"normalized": []
},
{
"id": "split_0_train_9661_entity",
"type": "progene_text",
"text": [
"5alpha-reductase"
],
"offsets": [
[
65,
81
]
],
"normalized": []
},
{
"id": "split_0_train_9662_entity",
"type": "progene_text",
"text": [
"3alpha-HSD"
],
"offsets": [
[
88,
98
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6185
|
split_0_train_6185
|
[
{
"id": "split_0_train_6185_passage",
"type": "progene_text",
"text": [
"Since increased levels of inflammatory cytokines have been detected in some skin diseases then these cytokines might play a role in the differentiation of keratinocytes ."
],
"offsets": [
[
0,
170
]
]
}
] |
[
{
"id": "split_0_train_9663_entity",
"type": "progene_text",
"text": [
"cytokines"
],
"offsets": [
[
39,
48
]
],
"normalized": []
},
{
"id": "split_0_train_9664_entity",
"type": "progene_text",
"text": [
"cytokines"
],
"offsets": [
[
101,
110
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6186
|
split_0_train_6186
|
[
{
"id": "split_0_train_6186_passage",
"type": "progene_text",
"text": [
"In this regard , we found that interleukin-4 ( IL-4 ) induced the expression of 3beta-HSD in HaCaT cells , thus allowing the cells to produce a different set of sex steroids from adrenal C19 precursors ."
],
"offsets": [
[
0,
203
]
]
}
] |
[
{
"id": "split_0_train_9665_entity",
"type": "progene_text",
"text": [
"interleukin-4"
],
"offsets": [
[
31,
44
]
],
"normalized": []
},
{
"id": "split_0_train_9666_entity",
"type": "progene_text",
"text": [
"IL-4"
],
"offsets": [
[
47,
51
]
],
"normalized": []
},
{
"id": "split_0_train_9667_entity",
"type": "progene_text",
"text": [
"3beta-HSD"
],
"offsets": [
[
80,
89
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6187
|
split_0_train_6187
|
[
{
"id": "split_0_train_6187_passage",
"type": "progene_text",
"text": [
"The present data thus indicate that HaCaT cells are a useful model to further study the regulation of the enzymes involved in the metabolism of sex steroids in keratinocytes ."
],
"offsets": [
[
0,
175
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6188
|
split_0_train_6188
|
[
{
"id": "split_0_train_6188_passage",
"type": "progene_text",
"text": [
"Stat3 - dependent induction of interleukin-3 receptor expression in leukemia inhibitory factor - stimulated M1 mouse leukemia cells ."
],
"offsets": [
[
0,
133
]
]
}
] |
[
{
"id": "split_0_train_9668_entity",
"type": "progene_text",
"text": [
"Stat3"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "split_0_train_9669_entity",
"type": "progene_text",
"text": [
"interleukin-3 receptor"
],
"offsets": [
[
31,
53
]
],
"normalized": []
},
{
"id": "split_0_train_9670_entity",
"type": "progene_text",
"text": [
"leukemia inhibitory factor"
],
"offsets": [
[
68,
94
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6189
|
split_0_train_6189
|
[
{
"id": "split_0_train_6189_passage",
"type": "progene_text",
"text": [
"M1 mouse leukemia cells differentiate to macrophages / monocytes by the stimulation of interleukin-6 ( IL-6 ) / leukemia inhibitory factor ( LIF ) ."
],
"offsets": [
[
0,
148
]
]
}
] |
[
{
"id": "split_0_train_9671_entity",
"type": "progene_text",
"text": [
"interleukin-6"
],
"offsets": [
[
87,
100
]
],
"normalized": []
},
{
"id": "split_0_train_9672_entity",
"type": "progene_text",
"text": [
"IL-6"
],
"offsets": [
[
103,
107
]
],
"normalized": []
},
{
"id": "split_0_train_9673_entity",
"type": "progene_text",
"text": [
"leukemia inhibitory factor"
],
"offsets": [
[
112,
138
]
],
"normalized": []
},
{
"id": "split_0_train_9674_entity",
"type": "progene_text",
"text": [
"LIF"
],
"offsets": [
[
141,
144
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6190
|
split_0_train_6190
|
[
{
"id": "split_0_train_6190_passage",
"type": "progene_text",
"text": [
"To identify new LIF - induced genes , we have performed representational difference analysis using M1 cells and cloned mouse interleukin-3 ( IL-3 ) receptor beta subunit gene ."
],
"offsets": [
[
0,
176
]
]
}
] |
[
{
"id": "split_0_train_9675_entity",
"type": "progene_text",
"text": [
"LIF"
],
"offsets": [
[
16,
19
]
],
"normalized": []
},
{
"id": "split_0_train_9676_entity",
"type": "progene_text",
"text": [
"interleukin-3 ( IL-3 ) receptor beta"
],
"offsets": [
[
125,
161
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6191
|
split_0_train_6191
|
[
{
"id": "split_0_train_6191_passage",
"type": "progene_text",
"text": [
"The mRNA expression of both IL-3 receptor ( IL-3R ) alpha and beta subunits is upregulated after 1 h stimulation of LIF and remains to be elevated along the differentiation of M1 cells ."
],
"offsets": [
[
0,
186
]
]
}
] |
[
{
"id": "split_0_train_9677_entity",
"type": "progene_text",
"text": [
"IL-3 receptor ( IL-3R ) alpha and beta"
],
"offsets": [
[
28,
66
]
],
"normalized": []
},
{
"id": "split_0_train_9678_entity",
"type": "progene_text",
"text": [
"LIF"
],
"offsets": [
[
116,
119
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6192
|
split_0_train_6192
|
[
{
"id": "split_0_train_6192_passage",
"type": "progene_text",
"text": [
"This induction is almost completely suppressed in M1 cells expressing a dominant negative form of Stat3 ."
],
"offsets": [
[
0,
105
]
]
}
] |
[
{
"id": "split_0_train_9679_entity",
"type": "progene_text",
"text": [
"Stat3"
],
"offsets": [
[
98,
103
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6193
|
split_0_train_6193
|
[
{
"id": "split_0_train_6193_passage",
"type": "progene_text",
"text": [
"Furthermore , we show that IL-3 - induced Stat5 phosphorylation increases in LIF - stimulated M1 cells ."
],
"offsets": [
[
0,
104
]
]
}
] |
[
{
"id": "split_0_train_9680_entity",
"type": "progene_text",
"text": [
"IL-3"
],
"offsets": [
[
27,
31
]
],
"normalized": []
},
{
"id": "split_0_train_9681_entity",
"type": "progene_text",
"text": [
"Stat5"
],
"offsets": [
[
42,
47
]
],
"normalized": []
},
{
"id": "split_0_train_9682_entity",
"type": "progene_text",
"text": [
"LIF"
],
"offsets": [
[
77,
80
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6194
|
split_0_train_6194
|
[
{
"id": "split_0_train_6194_passage",
"type": "progene_text",
"text": [
"These results suggest that Stat3 may play a role in the differentiation of myeloid cells by regulating IL-3R expression ."
],
"offsets": [
[
0,
121
]
]
}
] |
[
{
"id": "split_0_train_9683_entity",
"type": "progene_text",
"text": [
"Stat3"
],
"offsets": [
[
27,
32
]
],
"normalized": []
},
{
"id": "split_0_train_9684_entity",
"type": "progene_text",
"text": [
"IL-3R"
],
"offsets": [
[
103,
108
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6195
|
split_0_train_6195
|
[
{
"id": "split_0_train_6195_passage",
"type": "progene_text",
"text": [
"Anp32e ( Cpd1 ) and related protein phosphatase 2 inhibitors ."
],
"offsets": [
[
0,
62
]
]
}
] |
[
{
"id": "split_0_train_9685_entity",
"type": "progene_text",
"text": [
"Anp32e"
],
"offsets": [
[
0,
6
]
],
"normalized": []
},
{
"id": "split_0_train_9686_entity",
"type": "progene_text",
"text": [
"Cpd1"
],
"offsets": [
[
9,
13
]
],
"normalized": []
},
{
"id": "split_0_train_9687_entity",
"type": "progene_text",
"text": [
"protein phosphatase 2"
],
"offsets": [
[
28,
49
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6196
|
split_0_train_6196
|
[
{
"id": "split_0_train_6196_passage",
"type": "progene_text",
"text": [
"Mouse Anp32e ( Acidic leucine - rich nuclear phosphoprotein 32 family , member e : NM_023210 , P97822 , formerly Cpd1 ) , a protein identified in postnatal cerebellum by differential display , belongs to the superfamily of leucine rich repeat ( LRR ) proteins and to the Acidic Nuclear Phosphoprotein 32 ( ANP32 ) family of protein phosphatase 2 ( PPP2 , formerly PP2A ) inhibitors ."
],
"offsets": [
[
0,
383
]
]
}
] |
[
{
"id": "split_0_train_9688_entity",
"type": "progene_text",
"text": [
"Anp32e"
],
"offsets": [
[
6,
12
]
],
"normalized": []
},
{
"id": "split_0_train_9689_entity",
"type": "progene_text",
"text": [
"Acidic leucine - rich nuclear phosphoprotein 32 family , member e"
],
"offsets": [
[
15,
80
]
],
"normalized": []
},
{
"id": "split_0_train_9690_entity",
"type": "progene_text",
"text": [
"Cpd1"
],
"offsets": [
[
113,
117
]
],
"normalized": []
},
{
"id": "split_0_train_9691_entity",
"type": "progene_text",
"text": [
"superfamily of leucine rich repeat ( LRR ) proteins"
],
"offsets": [
[
208,
259
]
],
"normalized": []
},
{
"id": "split_0_train_9692_entity",
"type": "progene_text",
"text": [
"Acidic Nuclear Phosphoprotein 32 ( ANP32 ) family"
],
"offsets": [
[
271,
320
]
],
"normalized": []
},
{
"id": "split_0_train_9693_entity",
"type": "progene_text",
"text": [
"protein phosphatase 2"
],
"offsets": [
[
324,
345
]
],
"normalized": []
},
{
"id": "split_0_train_9694_entity",
"type": "progene_text",
"text": [
"PPP2"
],
"offsets": [
[
348,
352
]
],
"normalized": []
},
{
"id": "split_0_train_9695_entity",
"type": "progene_text",
"text": [
"PP2A"
],
"offsets": [
[
364,
368
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6197
|
split_0_train_6197
|
[
{
"id": "split_0_train_6197_passage",
"type": "progene_text",
"text": [
"Two families of PPP2 inhibitor proteins have been described , ANP32 and SET , represented by the human proteins ANP32A ( NM_006305 , formerly LANP , PP32 , I1PPP2 , PHAPI , MAPM , mapmodulin ) and SET ( NM_003011 , formerly PHAPII , 2PPP2 , I2PPP2 , TAF-1BETA ) ."
],
"offsets": [
[
0,
263
]
]
}
] |
[
{
"id": "split_0_train_9696_entity",
"type": "progene_text",
"text": [
"PPP2"
],
"offsets": [
[
16,
20
]
],
"normalized": []
},
{
"id": "split_0_train_9697_entity",
"type": "progene_text",
"text": [
"ANP32"
],
"offsets": [
[
62,
67
]
],
"normalized": []
},
{
"id": "split_0_train_9698_entity",
"type": "progene_text",
"text": [
"SET"
],
"offsets": [
[
72,
75
]
],
"normalized": []
},
{
"id": "split_0_train_9699_entity",
"type": "progene_text",
"text": [
"ANP32A"
],
"offsets": [
[
112,
118
]
],
"normalized": []
},
{
"id": "split_0_train_9700_entity",
"type": "progene_text",
"text": [
"LANP"
],
"offsets": [
[
142,
146
]
],
"normalized": []
},
{
"id": "split_0_train_9701_entity",
"type": "progene_text",
"text": [
"PP32"
],
"offsets": [
[
149,
153
]
],
"normalized": []
},
{
"id": "split_0_train_9702_entity",
"type": "progene_text",
"text": [
"I1PPP2"
],
"offsets": [
[
156,
162
]
],
"normalized": []
},
{
"id": "split_0_train_9703_entity",
"type": "progene_text",
"text": [
"PHAPI"
],
"offsets": [
[
165,
170
]
],
"normalized": []
},
{
"id": "split_0_train_9704_entity",
"type": "progene_text",
"text": [
"MAPM"
],
"offsets": [
[
173,
177
]
],
"normalized": []
},
{
"id": "split_0_train_9705_entity",
"type": "progene_text",
"text": [
"mapmodulin"
],
"offsets": [
[
180,
190
]
],
"normalized": []
},
{
"id": "split_0_train_9706_entity",
"type": "progene_text",
"text": [
"SET"
],
"offsets": [
[
197,
200
]
],
"normalized": []
},
{
"id": "split_0_train_9707_entity",
"type": "progene_text",
"text": [
"PHAPII"
],
"offsets": [
[
224,
230
]
],
"normalized": []
},
{
"id": "split_0_train_9708_entity",
"type": "progene_text",
"text": [
"2PPP2"
],
"offsets": [
[
233,
238
]
],
"normalized": []
},
{
"id": "split_0_train_9709_entity",
"type": "progene_text",
"text": [
"I2PPP2"
],
"offsets": [
[
241,
247
]
],
"normalized": []
},
{
"id": "split_0_train_9710_entity",
"type": "progene_text",
"text": [
"TAF-1BETA"
],
"offsets": [
[
250,
259
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6198
|
split_0_train_6198
|
[
{
"id": "split_0_train_6198_passage",
"type": "progene_text",
"text": [
"Besides their common PPP2 inhibitor activity , described several years ago , these nucleo - cytoplasmic shuttling phosphoproteins have additional and very important functions recently reported ."
],
"offsets": [
[
0,
194
]
]
}
] |
[
{
"id": "split_0_train_9711_entity",
"type": "progene_text",
"text": [
"PPP2"
],
"offsets": [
[
21,
25
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6199
|
split_0_train_6199
|
[
{
"id": "split_0_train_6199_passage",
"type": "progene_text",
"text": [
"In HeLa cells , ANP32A , SET ( isoforms A and B ) and ANP32B ( APRIL ) , form a multi - subunit heterocomplex with ELAVL1 ( NM_001419 , formerly HuR ) , a protein that stabilizes short - lived mRNAs containing AU - rich elements ( AREs ) ."
],
"offsets": [
[
0,
239
]
]
}
] |
[
{
"id": "split_0_train_9712_entity",
"type": "progene_text",
"text": [
"ANP32A"
],
"offsets": [
[
16,
22
]
],
"normalized": []
},
{
"id": "split_0_train_9713_entity",
"type": "progene_text",
"text": [
"SET"
],
"offsets": [
[
25,
28
]
],
"normalized": []
},
{
"id": "split_0_train_9714_entity",
"type": "progene_text",
"text": [
"ANP32B"
],
"offsets": [
[
54,
60
]
],
"normalized": []
},
{
"id": "split_0_train_9715_entity",
"type": "progene_text",
"text": [
"APRIL"
],
"offsets": [
[
63,
68
]
],
"normalized": []
},
{
"id": "split_0_train_9716_entity",
"type": "progene_text",
"text": [
"ELAVL1"
],
"offsets": [
[
115,
121
]
],
"normalized": []
},
{
"id": "split_0_train_9717_entity",
"type": "progene_text",
"text": [
"HuR"
],
"offsets": [
[
145,
148
]
],
"normalized": []
}
] |
[] |
[] |
[] |
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