id
stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
split_0_train_6200
|
split_0_train_6200
|
[
{
"id": "split_0_train_6200_passage",
"type": "progene_text",
"text": [
"A similar heterocomplex , formed by SET ( A and B ) and ANP32A as major subunits , possess histone acetyltransferase inhibitory activity ( INHAT ) , and have a role in chromatin remodeling and transcriptional regulation ( histone code ) ."
],
"offsets": [
[
0,
238
]
]
}
] |
[
{
"id": "split_0_train_9718_entity",
"type": "progene_text",
"text": [
"SET"
],
"offsets": [
[
36,
39
]
],
"normalized": []
},
{
"id": "split_0_train_9719_entity",
"type": "progene_text",
"text": [
"ANP32A"
],
"offsets": [
[
56,
62
]
],
"normalized": []
},
{
"id": "split_0_train_9720_entity",
"type": "progene_text",
"text": [
"histone acetyltransferase"
],
"offsets": [
[
91,
116
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],
"normalized": []
},
{
"id": "split_0_train_9721_entity",
"type": "progene_text",
"text": [
"INHAT"
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"offsets": [
[
139,
144
]
],
"normalized": []
},
{
"id": "split_0_train_9722_entity",
"type": "progene_text",
"text": [
"histone"
],
"offsets": [
[
222,
229
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6201
|
split_0_train_6201
|
[
{
"id": "split_0_train_6201_passage",
"type": "progene_text",
"text": [
"The possible roles of these multifunctional proteins are discussed here , with emphasis on mouse Anp32e and the cerebellar tissue ."
],
"offsets": [
[
0,
131
]
]
}
] |
[
{
"id": "split_0_train_9723_entity",
"type": "progene_text",
"text": [
"Anp32e"
],
"offsets": [
[
97,
103
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6202
|
split_0_train_6202
|
[
{
"id": "split_0_train_6202_passage",
"type": "progene_text",
"text": [
"Reconstitution of ATP - dependent cGMP transport into proteoliposomes by membrane proteins from human erythrocytes ."
],
"offsets": [
[
0,
116
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6203
|
split_0_train_6203
|
[
{
"id": "split_0_train_6203_passage",
"type": "progene_text",
"text": [
"The cellular efflux of cGMP from human erythrocytes has previously been characterized in functional studies ."
],
"offsets": [
[
0,
109
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6204
|
split_0_train_6204
|
[
{
"id": "split_0_train_6204_passage",
"type": "progene_text",
"text": [
"The purpose of the present study was to find membrane proteins with the ability to restore ATP - dependent uptake of cGMP into proteoliposomes ."
],
"offsets": [
[
0,
144
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6205
|
split_0_train_6205
|
[
{
"id": "split_0_train_6205_passage",
"type": "progene_text",
"text": [
"Human erythrocyte membranes were solubilized with CHAPS ( 3-([3-cholamidopropyl]dimethylammonio)-1-propanesulfonate ) and gel filtration gave three protein fractions with the ability to restore active transport ."
],
"offsets": [
[
0,
212
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6206
|
split_0_train_6206
|
[
{
"id": "split_0_train_6206_passage",
"type": "progene_text",
"text": [
"Only two of these fractions were retained on a lentil lectin column ."
],
"offsets": [
[
0,
69
]
]
}
] |
[
{
"id": "split_0_train_9724_entity",
"type": "progene_text",
"text": [
"lectin"
],
"offsets": [
[
54,
60
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6207
|
split_0_train_6207
|
[
{
"id": "split_0_train_6207_passage",
"type": "progene_text",
"text": [
"By using these two purification steps , active transport was 11 times higher in the first fraction compared to the original material and SDS-PAGE showed the presence of proteins with sizes of 145 kDa and 165 kDa ."
],
"offsets": [
[
0,
213
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6208
|
split_0_train_6208
|
[
{
"id": "split_0_train_6208_passage",
"type": "progene_text",
"text": [
"The second fraction gave 20 times higher active transport after purification and comprised proteins with sizes of 145 kDa and 180 kDa ."
],
"offsets": [
[
0,
135
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6209
|
split_0_train_6209
|
[
{
"id": "split_0_train_6209_passage",
"type": "progene_text",
"text": [
"At present three members of the MRP ( multi - resistance associated protein ) family have been detected in human erythrocytes : MRPI , MRP4 and MRP5 ."
],
"offsets": [
[
0,
150
]
]
}
] |
[
{
"id": "split_0_train_9725_entity",
"type": "progene_text",
"text": [
"MRP ( multi - resistance associated protein ) family"
],
"offsets": [
[
32,
84
]
],
"normalized": []
},
{
"id": "split_0_train_9726_entity",
"type": "progene_text",
"text": [
"MRPI"
],
"offsets": [
[
128,
132
]
],
"normalized": []
},
{
"id": "split_0_train_9727_entity",
"type": "progene_text",
"text": [
"MRP4"
],
"offsets": [
[
135,
139
]
],
"normalized": []
},
{
"id": "split_0_train_9728_entity",
"type": "progene_text",
"text": [
"MRP5"
],
"offsets": [
[
144,
148
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6210
|
split_0_train_6210
|
[
{
"id": "split_0_train_6210_passage",
"type": "progene_text",
"text": [
"The last two proteins have been shown to transport cyclic nucleotides ."
],
"offsets": [
[
0,
71
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6211
|
split_0_train_6211
|
[
{
"id": "split_0_train_6211_passage",
"type": "progene_text",
"text": [
"The present findings are compatible with MRP4 as the 145 kDa protein , MRP5 as the 165 kDa protein and MRP1 as the 180 kDa protein ."
],
"offsets": [
[
0,
132
]
]
}
] |
[
{
"id": "split_0_train_9729_entity",
"type": "progene_text",
"text": [
"MRP4"
],
"offsets": [
[
41,
45
]
],
"normalized": []
},
{
"id": "split_0_train_9730_entity",
"type": "progene_text",
"text": [
"MRP5"
],
"offsets": [
[
71,
75
]
],
"normalized": []
},
{
"id": "split_0_train_9731_entity",
"type": "progene_text",
"text": [
"MRP1"
],
"offsets": [
[
103,
107
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6212
|
split_0_train_6212
|
[
{
"id": "split_0_train_6212_passage",
"type": "progene_text",
"text": [
"However , the 145 kDa protein could also be SMRP ( short multi - resistance protein ) , the gene splice variant of MRP5 ."
],
"offsets": [
[
0,
121
]
]
}
] |
[
{
"id": "split_0_train_9732_entity",
"type": "progene_text",
"text": [
"SMRP"
],
"offsets": [
[
44,
48
]
],
"normalized": []
},
{
"id": "split_0_train_9733_entity",
"type": "progene_text",
"text": [
"short multi - resistance protein"
],
"offsets": [
[
51,
83
]
],
"normalized": []
},
{
"id": "split_0_train_9734_entity",
"type": "progene_text",
"text": [
"MRP5"
],
"offsets": [
[
115,
119
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6213
|
split_0_train_6213
|
[
{
"id": "split_0_train_6213_passage",
"type": "progene_text",
"text": [
"Immunoprecipitation of MRP5 from CHAPS - solubilized extract reduced active transport and specific binding by about 45 % and 40 % , respectively ."
],
"offsets": [
[
0,
146
]
]
}
] |
[
{
"id": "split_0_train_9735_entity",
"type": "progene_text",
"text": [
"MRP5"
],
"offsets": [
[
23,
27
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6214
|
split_0_train_6214
|
[
{
"id": "split_0_train_6214_passage",
"type": "progene_text",
"text": [
"This shows that MRP5 is an important cGMP - transporting protein in human erythrocytes ."
],
"offsets": [
[
0,
88
]
]
}
] |
[
{
"id": "split_0_train_9736_entity",
"type": "progene_text",
"text": [
"MRP5"
],
"offsets": [
[
16,
20
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6215
|
split_0_train_6215
|
[
{
"id": "split_0_train_6215_passage",
"type": "progene_text",
"text": [
"Calcium - regulated changes in mitochondrial phenotype in skeletal muscle cells ."
],
"offsets": [
[
0,
81
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6216
|
split_0_train_6216
|
[
{
"id": "split_0_train_6216_passage",
"type": "progene_text",
"text": [
"Cytochrome c expression and mitochondrial biogenesis can be invoked by elevated intracellular Ca(2+) in muscle cells ."
],
"offsets": [
[
0,
118
]
]
}
] |
[
{
"id": "split_0_train_9737_entity",
"type": "progene_text",
"text": [
"Cytochrome c"
],
"offsets": [
[
0,
12
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6217
|
split_0_train_6217
|
[
{
"id": "split_0_train_6217_passage",
"type": "progene_text",
"text": [
"To characterize the potential role of Ca(2+) as a messenger involved in mitochondrial biogenesis in muscle , we determined the effects of the Ca ( 2 + ) ionophore A - 23187 on the expression of nuclear - and mitochondrially encoded genes ."
],
"offsets": [
[
0,
239
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6218
|
split_0_train_6218
|
[
{
"id": "split_0_train_6218_passage",
"type": "progene_text",
"text": [
"Treatment of myotubes with 1 microM A-23187 for 48 - 96 h increased nuclear - encoded beta - subunit F(1) ATPase and malate dehydrogenase ( MDH ) mRNA levels by 50 - 100 % ( P < 0.05 ) but decreased mRNA levels of glutamate dehydrogenase ( GDH ) by 19 % ( P < 0.05 ) ."
],
"offsets": [
[
0,
268
]
]
}
] |
[
{
"id": "split_0_train_9738_entity",
"type": "progene_text",
"text": [
"beta - subunit F(1) ATPase"
],
"offsets": [
[
86,
112
]
],
"normalized": []
},
{
"id": "split_0_train_9739_entity",
"type": "progene_text",
"text": [
"malate dehydrogenase"
],
"offsets": [
[
117,
137
]
],
"normalized": []
},
{
"id": "split_0_train_9740_entity",
"type": "progene_text",
"text": [
"MDH"
],
"offsets": [
[
140,
143
]
],
"normalized": []
},
{
"id": "split_0_train_9741_entity",
"type": "progene_text",
"text": [
"glutamate dehydrogenase"
],
"offsets": [
[
214,
237
]
],
"normalized": []
},
{
"id": "split_0_train_9742_entity",
"type": "progene_text",
"text": [
"GDH"
],
"offsets": [
[
240,
243
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6219
|
split_0_train_6219
|
[
{
"id": "split_0_train_6219_passage",
"type": "progene_text",
"text": [
"mRNA levels of the cytochrome c oxidase ( COX ) nuclear - encoded subunits IV , Vb , and VIc were unchanged , whereas the mitochondrially encoded subunits COX II and COX III were decreased by 30 and 70 % , respectively ( P < 0.05 ) ."
],
"offsets": [
[
0,
233
]
]
}
] |
[
{
"id": "split_0_train_9743_entity",
"type": "progene_text",
"text": [
"cytochrome c oxidase"
],
"offsets": [
[
19,
39
]
],
"normalized": []
},
{
"id": "split_0_train_9744_entity",
"type": "progene_text",
"text": [
"COX"
],
"offsets": [
[
42,
45
]
],
"normalized": []
},
{
"id": "split_0_train_9745_entity",
"type": "progene_text",
"text": [
"COX II"
],
"offsets": [
[
155,
161
]
],
"normalized": []
},
{
"id": "split_0_train_9746_entity",
"type": "progene_text",
"text": [
"COX III"
],
"offsets": [
[
166,
173
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6220
|
split_0_train_6220
|
[
{
"id": "split_0_train_6220_passage",
"type": "progene_text",
"text": [
"This was paralleled by a 20 % decrease ( P < 0.05 ) in COX activity ."
],
"offsets": [
[
0,
69
]
]
}
] |
[
{
"id": "split_0_train_9747_entity",
"type": "progene_text",
"text": [
"COX"
],
"offsets": [
[
55,
58
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6221
|
split_0_train_6221
|
[
{
"id": "split_0_train_6221_passage",
"type": "progene_text",
"text": [
"These data suggest that cytoplasmic Ca(2+) differentially regulates the mRNA level of nuclear and mitochondrial genes ."
],
"offsets": [
[
0,
119
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6222
|
split_0_train_6222
|
[
{
"id": "split_0_train_6222_passage",
"type": "progene_text",
"text": [
"The decline in COX II and III mRNA may be mediated by Tfam , because A - 23187 modestly reduced Tfam levels by 48 h ."
],
"offsets": [
[
0,
117
]
]
}
] |
[
{
"id": "split_0_train_9748_entity",
"type": "progene_text",
"text": [
"COX II and III"
],
"offsets": [
[
15,
29
]
],
"normalized": []
},
{
"id": "split_0_train_9749_entity",
"type": "progene_text",
"text": [
"Tfam"
],
"offsets": [
[
54,
58
]
],
"normalized": []
},
{
"id": "split_0_train_9750_entity",
"type": "progene_text",
"text": [
"Tfam"
],
"offsets": [
[
96,
100
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6223
|
split_0_train_6223
|
[
{
"id": "split_0_train_6223_passage",
"type": "progene_text",
"text": [
"A-23187 induced time - dependent increases in Egr-1 mRNA , along with the activation of ERK1 / 2 and AMP - activated protein kinase ."
],
"offsets": [
[
0,
133
]
]
}
] |
[
{
"id": "split_0_train_9751_entity",
"type": "progene_text",
"text": [
"Egr-1"
],
"offsets": [
[
46,
51
]
],
"normalized": []
},
{
"id": "split_0_train_9752_entity",
"type": "progene_text",
"text": [
"ERK1 / 2"
],
"offsets": [
[
88,
96
]
],
"normalized": []
},
{
"id": "split_0_train_9753_entity",
"type": "progene_text",
"text": [
"AMP - activated protein kinase"
],
"offsets": [
[
101,
131
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6224
|
split_0_train_6224
|
[
{
"id": "split_0_train_6224_passage",
"type": "progene_text",
"text": [
"MEK inhibition with PD-98059 attenuated the increase in Egr-1 mRNA ."
],
"offsets": [
[
0,
68
]
]
}
] |
[
{
"id": "split_0_train_9754_entity",
"type": "progene_text",
"text": [
"MEK"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "split_0_train_9755_entity",
"type": "progene_text",
"text": [
"Egr-1"
],
"offsets": [
[
56,
61
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6225
|
split_0_train_6225
|
[
{
"id": "split_0_train_6225_passage",
"type": "progene_text",
"text": [
"A-23187 also increased Egr-1 , serum response factor , and Sp1 protein expression , transcription factors implicated in mitochondrial biogenesis ."
],
"offsets": [
[
0,
146
]
]
}
] |
[
{
"id": "split_0_train_9756_entity",
"type": "progene_text",
"text": [
"Egr-1"
],
"offsets": [
[
23,
28
]
],
"normalized": []
},
{
"id": "split_0_train_9757_entity",
"type": "progene_text",
"text": [
"serum response factor"
],
"offsets": [
[
31,
52
]
],
"normalized": []
},
{
"id": "split_0_train_9758_entity",
"type": "progene_text",
"text": [
"Sp1"
],
"offsets": [
[
59,
62
]
],
"normalized": []
},
{
"id": "split_0_train_9759_entity",
"type": "progene_text",
"text": [
"transcription factors"
],
"offsets": [
[
84,
105
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6226
|
split_0_train_6226
|
[
{
"id": "split_0_train_6226_passage",
"type": "progene_text",
"text": [
"Egr-1 overexpression increased nuclear - encoded cytochrome c transcriptional activation by 1.5 - fold ( P < 0.05 ) and reduced GDH mRNA by 37 % ( P < 0.05 ) but had no effect on MDH or beta - subunit F ( 1 ) ATPase mRNA ."
],
"offsets": [
[
0,
222
]
]
}
] |
[
{
"id": "split_0_train_9760_entity",
"type": "progene_text",
"text": [
"Egr-1"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "split_0_train_9761_entity",
"type": "progene_text",
"text": [
"cytochrome c"
],
"offsets": [
[
49,
61
]
],
"normalized": []
},
{
"id": "split_0_train_9762_entity",
"type": "progene_text",
"text": [
"GDH"
],
"offsets": [
[
128,
131
]
],
"normalized": []
},
{
"id": "split_0_train_9763_entity",
"type": "progene_text",
"text": [
"MDH"
],
"offsets": [
[
179,
182
]
],
"normalized": []
},
{
"id": "split_0_train_9764_entity",
"type": "progene_text",
"text": [
"beta - subunit F ( 1 ) ATPase"
],
"offsets": [
[
186,
215
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6227
|
split_0_train_6227
|
[
{
"id": "split_0_train_6227_passage",
"type": "progene_text",
"text": [
"These results indicate that changes in intracellular Ca(2+) can modify mitochondrial phenotype , in part via the involvement of Egr-1 ."
],
"offsets": [
[
0,
135
]
]
}
] |
[
{
"id": "split_0_train_9765_entity",
"type": "progene_text",
"text": [
"Egr-1"
],
"offsets": [
[
128,
133
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6228
|
split_0_train_6228
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"Fructan metabolising enzymes in rhizophores of Vernonia herbacea upon excision of aerial organs ."
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}
] |
[] |
[] |
[] |
[] |
split_0_train_6229
|
split_0_train_6229
|
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{
"id": "split_0_train_6229_passage",
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"The activities of fructan metabolising enzymes and fructan contents are reported for rhizophores of Vernonia herbacea ( Vell. ) Rusby induced to sprouting by shoot excision ."
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[
0,
174
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}
] |
[] |
[] |
[] |
[] |
split_0_train_6230
|
split_0_train_6230
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"The activities of fructan exohydrolase ( 1-FEH ) , sucrose : sucrose fructosyltransferase ( 1-SST ) , fructan : fructan fructosyltransferase ( 1-FFT ) and invertase ( INV ) and the fructan contents were analysed every 3-4 days for 1 month by colorimetric and chromatographic methods ."
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"text": [
"INV"
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167,
170
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}
] |
[] |
[] |
[] |
split_0_train_6231
|
split_0_train_6231
|
[
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"type": "progene_text",
"text": [
"Sprouting of new shoots started on day 9 ."
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"offsets": [
[
0,
42
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6232
|
split_0_train_6232
|
[
{
"id": "split_0_train_6232_passage",
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"text": [
"1-FEH activity increased after day 13 and reached its maximum value 20 days after shoot excision ."
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"offsets": [
[
0,
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}
] |
[
{
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"text": [
"1-FEH"
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0,
5
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}
] |
[] |
[] |
[] |
split_0_train_6233
|
split_0_train_6233
|
[
{
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"text": [
"A gradual decrease in 1-SST activity was detected between days 3 and 9 ."
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0,
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}
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{
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"text": [
"1-SST"
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22,
27
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}
] |
[] |
[] |
[] |
split_0_train_6234
|
split_0_train_6234
|
[
{
"id": "split_0_train_6234_passage",
"type": "progene_text",
"text": [
"1-FFT activity exhibited fluctuations throughout the experimental period and a peak of activity for invertase was detected 9 days after shoot excision ."
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[
0,
152
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}
] |
[
{
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"type": "progene_text",
"text": [
"1-FFT"
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[
0,
5
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}
] |
[] |
[] |
[] |
split_0_train_6235
|
split_0_train_6235
|
[
{
"id": "split_0_train_6235_passage",
"type": "progene_text",
"text": [
"Variation in fructan contents in vivo included a decrease until day 13 after which , levels remained practically unchanged ."
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"offsets": [
[
0,
124
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6236
|
split_0_train_6236
|
[
{
"id": "split_0_train_6236_passage",
"type": "progene_text",
"text": [
"Fructan depolymerization and sprouting are concomitant processes in V. herbacea and can be induced by shoot excision at any phenological phase ."
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0,
144
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6237
|
split_0_train_6237
|
[
{
"id": "split_0_train_6237_passage",
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"text": [
"1-FEH and 1-FFT seemed to act in a concerted way to catalyse fructan depolymerization , while 1-SST was inhibited , possibly due to interruption of sucrose supply to rhizophores from the aerial organs ."
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202
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}
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"text": [
"1-SST"
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94,
99
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}
] |
[] |
[] |
[] |
split_0_train_6238
|
split_0_train_6238
|
[
{
"id": "split_0_train_6238_passage",
"type": "progene_text",
"text": [
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}
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"text": [
"cytokines"
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38,
47
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}
] |
[] |
[] |
[] |
split_0_train_6239
|
split_0_train_6239
|
[
{
"id": "split_0_train_6239_passage",
"type": "progene_text",
"text": [
"Eosinophil - mediated diseases , such as allergic asthma , eosinophilic fasciitis , and certain hypersensitivity pulmonary disorders , are characterized by eosinophil infiltration and tissue injury ."
],
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[
0,
199
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6240
|
split_0_train_6240
|
[
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"id": "split_0_train_6240_passage",
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"text": [
"Mast cells and T cells often colocalize to these areas ."
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"offsets": [
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0,
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}
] |
[] |
[] |
[] |
[] |
split_0_train_6241
|
split_0_train_6241
|
[
{
"id": "split_0_train_6241_passage",
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"text": [
"Recent data suggest that mast cells can contribute to eosinophil - mediated inflammatory responses ."
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"offsets": [
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0,
100
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}
] |
[] |
[] |
[] |
[] |
split_0_train_6242
|
split_0_train_6242
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[
{
"id": "split_0_train_6242_passage",
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"text": [
"high - affinity receptor ( FcepsilonRI ) for IgE"
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83,
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}
] |
[] |
[] |
[] |
split_0_train_6243
|
split_0_train_6243
|
[
{
"id": "split_0_train_6243_passage",
"type": "progene_text",
"text": [
"The liberation of proteases , leukotrienes , lipid mediators , and histamine can contribute to tissue inflammation and allow recruitment of eosinophils to tissue ."
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[
0,
163
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}
] |
[] |
[] |
[] |
[] |
split_0_train_6244
|
split_0_train_6244
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{
"id": "split_0_train_6244_passage",
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"In addition , the synthesis and expression of a plethora of cytokines and chemokines ( such as granulocyte - macrophage colony - stimulating factor [ GM-CSF ] , interleukin-1 [ IL-1 ] , IL-3 , IL-5 , tumor necrosis factor - alpha [ TNF-alpha ] , and the chemokines IL-8 , regulated upon activation normal T cell expressed and secreted [ RANTES ] , monocyte chemotactic protein-1 [ MCP-1 ] , and eotaxin ) by mast cells can influence eosinophil biology ."
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"text": [
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395,
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] |
[] |
[] |
[] |
split_0_train_6245
|
split_0_train_6245
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[
{
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"text": [
"Stem cell factor ( SCF ) - c-kit , cytokine - cytokine receptor , and chemokine - chemokine receptor ( CCR3 ) interactions leading to nuclear factor kappaB ( NF-kappaB ) , mitogen - activated protein kinase ( MAPK ) expression , and other signaling pathways can modulate eosinophil function ."
],
"offsets": [
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0,
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}
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{
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{
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158,
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{
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172,
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"text": [
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209,
213
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}
] |
[] |
[] |
[] |
split_0_train_6246
|
split_0_train_6246
|
[
{
"id": "split_0_train_6246_passage",
"type": "progene_text",
"text": [
"Eosinophil hematopoiesis , activation , survival , and elaboration of mediators can all be regulated thus by mast cells in tissue ."
],
"offsets": [
[
0,
131
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6247
|
split_0_train_6247
|
[
{
"id": "split_0_train_6247_passage",
"type": "progene_text",
"text": [
"Moreover , because eosinophils can secrete SCF , eosinophils can regulate mast cell function in a paracrine manner ."
],
"offsets": [
[
0,
116
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]
}
] |
[
{
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"type": "progene_text",
"text": [
"SCF"
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"offsets": [
[
43,
46
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6248
|
split_0_train_6248
|
[
{
"id": "split_0_train_6248_passage",
"type": "progene_text",
"text": [
"This two - way interaction between eosinophils and mast cells can pave the way for chronic inflammatory responses in a variety of human diseases ."
],
"offsets": [
[
0,
146
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6249
|
split_0_train_6249
|
[
{
"id": "split_0_train_6249_passage",
"type": "progene_text",
"text": [
"This review summarizes this pivotal interaction between human mast cells and eosinophils ."
],
"offsets": [
[
0,
90
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6250
|
split_0_train_6250
|
[
{
"id": "split_0_train_6250_passage",
"type": "progene_text",
"text": [
"2S storage protein gene of Douglas - fir : characterization and activity of promoter in transgenic tobacco seeds ."
],
"offsets": [
[
0,
114
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]
}
] |
[
{
"id": "split_0_train_9814_entity",
"type": "progene_text",
"text": [
"2S storage protein"
],
"offsets": [
[
0,
18
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6251
|
split_0_train_6251
|
[
{
"id": "split_0_train_6251_passage",
"type": "progene_text",
"text": [
"To date a few sequences regulating expression of conifer seed - specific genes have been reported ."
],
"offsets": [
[
0,
99
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6252
|
split_0_train_6252
|
[
{
"id": "split_0_train_6252_passage",
"type": "progene_text",
"text": [
"To characterize Douglas - fir ( Pseudotsuga menziesii [ Mirb ] Franco ) 2S albumin storage protein genes , a genomic DNA sequence containing upstream promoter sequences was isolated by screening a Douglas - fir genomic library ."
],
"offsets": [
[
0,
228
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]
}
] |
[
{
"id": "split_0_train_9815_entity",
"type": "progene_text",
"text": [
"2S albumin"
],
"offsets": [
[
72,
82
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6253
|
split_0_train_6253
|
[
{
"id": "split_0_train_6253_passage",
"type": "progene_text",
"text": [
"Sequence analysis of the Douglas - fir gPm2S1 promoter revealed the presence of RY-repeated elements ( GCATGC ) , and multiple E-box motifs ( CANNTG ) and ACGT - core elements , features characteristic of 2S storage protein genes in angiosperms ."
],
"offsets": [
[
0,
246
]
]
}
] |
[
{
"id": "split_0_train_9816_entity",
"type": "progene_text",
"text": [
"2S storage protein"
],
"offsets": [
[
205,
223
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6254
|
split_0_train_6254
|
[
{
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"text": [
"When fused to the GUS reporter gene , the 1.16 kb Douglas -fir 2S promoter sequence was sufficient to direct transient expression in both developing Douglas - fir embryos and maternally derived haploid megagametophytes ."
],
"offsets": [
[
0,
220
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]
}
] |
[
{
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"text": [
"2S"
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[
63,
65
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}
] |
[] |
[] |
[] |
split_0_train_6255
|
split_0_train_6255
|
[
{
"id": "split_0_train_6255_passage",
"type": "progene_text",
"text": [
"Analysis of this promoter construct in transgenic tobacco showed that expression was restricted to embryo and endosperm in developing seeds and was not detected in vegetative tissues of two - week - old seedlings ."
],
"offsets": [
[
0,
214
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6256
|
split_0_train_6256
|
[
{
"id": "split_0_train_6256_passage",
"type": "progene_text",
"text": [
"These results strongly suggest that both structural and regulatory elements as well as upstream signaling components controlling the expression of 2S albumin genes are highly conserved during evolution ."
],
"offsets": [
[
0,
203
]
]
}
] |
[
{
"id": "split_0_train_9819_entity",
"type": "progene_text",
"text": [
"2S albumin"
],
"offsets": [
[
147,
157
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6257
|
split_0_train_6257
|
[
{
"id": "split_0_train_6257_passage",
"type": "progene_text",
"text": [
"Myelin basic protein - diverse conformational states of an intrinsically unstructured protein and its roles in myelin assembly and multiple sclerosis ."
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[
0,
151
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]
}
] |
[
{
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"type": "progene_text",
"text": [
"Myelin basic protein"
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"offsets": [
[
0,
20
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}
] |
[] |
[] |
[] |
split_0_train_6258
|
split_0_train_6258
|
[
{
"id": "split_0_train_6258_passage",
"type": "progene_text",
"text": [
"The 18.5 kDa isoform of myelin basic protein ( MBP ) is a major component of the myelin sheath in the central nervous system of higher vertebrates , and a member of a larger family of proteins with a multiplicity of forms and post - translational modifications ( PTMs ) ."
],
"offsets": [
[
0,
271
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]
}
] |
[
{
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24,
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"type": "progene_text",
"text": [
"MBP"
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"offsets": [
[
47,
50
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6259
|
split_0_train_6259
|
[
{
"id": "split_0_train_6259_passage",
"type": "progene_text",
"text": [
"The 18.5 kDa protein is the exemplar of the family , being most abundant in adult myelin , and thus the most - studied ."
],
"offsets": [
[
0,
120
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6260
|
split_0_train_6260
|
[
{
"id": "split_0_train_6260_passage",
"type": "progene_text",
"text": [
"It is peripherally membrane - associated , but has generally been investigated in isolated form ."
],
"offsets": [
[
0,
97
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6261
|
split_0_train_6261
|
[
{
"id": "split_0_train_6261_passage",
"type": "progene_text",
"text": [
"MBP is an ' intrinsically unstructured ' protein with a high proportion ( approximately 75 % ) of random coil , but postulated to have core elements of beta-sheet and alpha-helix ."
],
"offsets": [
[
0,
180
]
]
}
] |
[
{
"id": "split_0_train_9823_entity",
"type": "progene_text",
"text": [
"MBP"
],
"offsets": [
[
0,
3
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"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6262
|
split_0_train_6262
|
[
{
"id": "split_0_train_6262_passage",
"type": "progene_text",
"text": [
"We review here the properties of the MBP family , especially of the 18.5 kDa isoform , and discuss how its three - dimensional ( 3D ) structure may be resolved by direct techniques available to us , viz. , X-ray and electron crystallography , and solution and solid - state NMR spectrometry ."
],
"offsets": [
[
0,
292
]
]
}
] |
[
{
"id": "split_0_train_9824_entity",
"type": "progene_text",
"text": [
"MBP family"
],
"offsets": [
[
37,
47
]
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"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6263
|
split_0_train_6263
|
[
{
"id": "split_0_train_6263_passage",
"type": "progene_text",
"text": [
"In particular , we emphasise that creating an appropriate environment in which the protein can adopt a physiologically relevant fold is crucial to such endeavours ."
],
"offsets": [
[
0,
164
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6264
|
split_0_train_6264
|
[
{
"id": "split_0_train_6264_passage",
"type": "progene_text",
"text": [
"By solving the 3D structure of 18.5 kDa MBP and the effects of PTMs , we will attain a better understanding of myelin architecture , and of the molecular mechanisms that transpire in demyelinating diseases such as multiple sclerosis ."
],
"offsets": [
[
0,
234
]
]
}
] |
[
{
"id": "split_0_train_9825_entity",
"type": "progene_text",
"text": [
"MBP"
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"offsets": [
[
40,
43
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6265
|
split_0_train_6265
|
[
{
"id": "split_0_train_6265_passage",
"type": "progene_text",
"text": [
"Accumulation of maize chlorotic dwarf virus proteins in its plant host and leafhopper vector ."
],
"offsets": [
[
0,
94
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6266
|
split_0_train_6266
|
[
{
"id": "split_0_train_6266_passage",
"type": "progene_text",
"text": [
"The genome of Maize chlorotic dwarf virus ( MCDV ; genus Waikavirus ; family Sequiviridae ) consists of a monopartite positive - sense RNA genome encoding a single large polyprotein ."
],
"offsets": [
[
0,
183
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6267
|
split_0_train_6267
|
[
{
"id": "split_0_train_6267_passage",
"type": "progene_text",
"text": [
"Antibodies were produced to His - fusions of three undefined regions of the MCDV polyprotein : the N-terminus of the polyprotein ( R78 ) , a region between coat proteins ( CPs ) and the nucleotide - binding site ( NBS ) ( R37 ) , and a region between the NBS and a 3C - like protease ( R69 ) ."
],
"offsets": [
[
0,
293
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]
}
] |
[
{
"id": "split_0_train_9826_entity",
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156,
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172,
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"type": "progene_text",
"text": [
"3C - like protease"
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"offsets": [
[
265,
283
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6268
|
split_0_train_6268
|
[
{
"id": "split_0_train_6268_passage",
"type": "progene_text",
"text": [
"The R78 antibodies react with proteins of 50 kDa ( P50 ) , 35 kDa ( P35 ) , and 25 kDa ( P25 ) in virus preparations , and with P35 in plant extracts ."
],
"offsets": [
[
0,
151
]
]
}
] |
[
{
"id": "split_0_train_9829_entity",
"type": "progene_text",
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51,
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68,
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"P25"
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89,
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"type": "progene_text",
"text": [
"P35"
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"offsets": [
[
128,
131
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6269
|
split_0_train_6269
|
[
{
"id": "split_0_train_6269_passage",
"type": "progene_text",
"text": [
"In extracts of the leafhopper vector Graminella nigrifrons fed on MCDV - infected plants , the R78 antibodies reacted with P25 but not with P50 and P35 ."
],
"offsets": [
[
0,
153
]
]
}
] |
[
{
"id": "split_0_train_9833_entity",
"type": "progene_text",
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"P25"
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123,
126
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"id": "split_0_train_9834_entity",
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"P50"
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140,
143
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"type": "progene_text",
"text": [
"P35"
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"offsets": [
[
148,
151
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6270
|
split_0_train_6270
|
[
{
"id": "split_0_train_6270_passage",
"type": "progene_text",
"text": [
"The R69 antibodies bound proteins of approximately 36 kDa ( P36 ) , 30 kDa ( P30 ) , and 26 kDa ( P26 ) in virus preparations , and P36 and P26 in plant extracts ."
],
"offsets": [
[
0,
163
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]
}
] |
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{
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60,
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77,
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"text": [
"P26"
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"offsets": [
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140,
143
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6271
|
split_0_train_6271
|
[
{
"id": "split_0_train_6271_passage",
"type": "progene_text",
"text": [
"Antibodies to R37 reacted with a 26 - kDa protein in purified virus preparations , but not in plant extracts ."
],
"offsets": [
[
0,
110
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6272
|
split_0_train_6272
|
[
{
"id": "split_0_train_6272_passage",
"type": "progene_text",
"text": [
"Neither the R69 nor the R37 antibodies bound any proteins in G. nigrifrons ."
],
"offsets": [
[
0,
76
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6273
|
split_0_train_6273
|
[
{
"id": "split_0_train_6273_passage",
"type": "progene_text",
"text": [
"Thus , in addition to the three CPs , cysteine protease and RNA - dependent RNA polymerase , the MCDV polyprotein is apparently post - transitionally cleaved into P50 , P35 , P25 , P36 , P30 , and P26 ."
],
"offsets": [
[
0,
202
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]
}
] |
[
{
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32,
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169,
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175,
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181,
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187,
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"type": "progene_text",
"text": [
"P26"
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"offsets": [
[
197,
200
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6274
|
split_0_train_6274
|
[
{
"id": "split_0_train_6274_passage",
"type": "progene_text",
"text": [
"CD40 engagement enhances antigen - presenting langerhans cell priming of IFN-gamma - producing CD4 + and CD8 + T cells independently of IL-12 ."
],
"offsets": [
[
0,
143
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]
}
] |
[
{
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"type": "progene_text",
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"type": "progene_text",
"text": [
"IL-12"
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"offsets": [
[
136,
141
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6275
|
split_0_train_6275
|
[
{
"id": "split_0_train_6275_passage",
"type": "progene_text",
"text": [
"The delivery of CD40 signaling to APCs during T cell priming enhances many T cell - mediated immune responses ."
],
"offsets": [
[
0,
111
]
]
}
] |
[
{
"id": "split_0_train_9855_entity",
"type": "progene_text",
"text": [
"CD40"
],
"offsets": [
[
16,
20
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6276
|
split_0_train_6276
|
[
{
"id": "split_0_train_6276_passage",
"type": "progene_text",
"text": [
"Although CD40 signaling up - regulates APC production of IL-12 , the impact of this increased production on T cell priming is unclear ."
],
"offsets": [
[
0,
135
]
]
}
] |
[
{
"id": "split_0_train_9856_entity",
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"CD40"
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{
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"type": "progene_text",
"text": [
"IL-12"
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"offsets": [
[
57,
62
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6277
|
split_0_train_6277
|
[
{
"id": "split_0_train_6277_passage",
"type": "progene_text",
"text": [
"In this study an IL-12 - independent T cell - mediated immune response , contact hypersensitivity ( CHS ) , was used to further investigate the effect of CD40 ligation on the phenotypic development of Ag - specific CD4 ( + ) and CD8 ( + ) T cells ."
],
"offsets": [
[
0,
248
]
]
}
] |
[
{
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17,
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"type": "progene_text",
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154,
158
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{
"id": "split_0_train_9860_entity",
"type": "progene_text",
"text": [
"CD4"
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215,
218
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{
"id": "split_0_train_9861_entity",
"type": "progene_text",
"text": [
"CD8"
],
"offsets": [
[
229,
232
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6278
|
split_0_train_6278
|
[
{
"id": "split_0_train_6278_passage",
"type": "progene_text",
"text": [
"Normally , sensitization for CHS responses induces hapten - specific CD4 ( + ) T cells producing type 2 cytokines and CD8 ( + ) T cells producing IFN - gamma ."
],
"offsets": [
[
0,
159
]
]
}
] |
[
{
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69,
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{
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104,
113
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{
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"type": "progene_text",
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"CD8"
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118,
121
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{
"id": "split_0_train_9865_entity",
"type": "progene_text",
"text": [
"IFN - gamma"
],
"offsets": [
[
146,
157
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6279
|
split_0_train_6279
|
[
{
"id": "split_0_train_6279_passage",
"type": "progene_text",
"text": [
"Treatment of mice with agonist anti - CD40 mAb during sensitization with the hapten 2,4-dinitrofluorobenzene resulted in CHS responses of increased magnitude and duration ."
],
"offsets": [
[
0,
172
]
]
}
] |
[
{
"id": "split_0_train_9866_entity",
"type": "progene_text",
"text": [
"CD40"
],
"offsets": [
[
38,
42
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6280
|
split_0_train_6280
|
[
{
"id": "split_0_train_6280_passage",
"type": "progene_text",
"text": [
"These augmented responses in anti - CD40 Ab - treated mice correlated with increased numbers of hapten - specific CD4 ( + ) and CD8 ( + ) T cells producing IFN-gamma in the skin draining lymph nodes ."
],
"offsets": [
[
0,
200
]
]
}
] |
[
{
"id": "split_0_train_9867_entity",
"type": "progene_text",
"text": [
"CD40"
],
"offsets": [
[
36,
40
]
],
"normalized": []
},
{
"id": "split_0_train_9868_entity",
"type": "progene_text",
"text": [
"CD4"
],
"offsets": [
[
114,
117
]
],
"normalized": []
},
{
"id": "split_0_train_9869_entity",
"type": "progene_text",
"text": [
"CD8"
],
"offsets": [
[
128,
131
]
],
"normalized": []
},
{
"id": "split_0_train_9870_entity",
"type": "progene_text",
"text": [
"IFN-gamma"
],
"offsets": [
[
156,
165
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6281
|
split_0_train_6281
|
[
{
"id": "split_0_train_6281_passage",
"type": "progene_text",
"text": [
"Identical results were observed using IL-12 ( -/- ) mice , indicating that CD40 ligation promotes CHS responses and development of IFN-gamma - producing CD4 ( + ) and CD8 ( + ) T cells in the absence of IL-12 ."
],
"offsets": [
[
0,
210
]
]
}
] |
[
{
"id": "split_0_train_9871_entity",
"type": "progene_text",
"text": [
"IL-12"
],
"offsets": [
[
38,
43
]
],
"normalized": []
},
{
"id": "split_0_train_9872_entity",
"type": "progene_text",
"text": [
"CD40"
],
"offsets": [
[
75,
79
]
],
"normalized": []
},
{
"id": "split_0_train_9873_entity",
"type": "progene_text",
"text": [
"IFN-gamma"
],
"offsets": [
[
131,
140
]
],
"normalized": []
},
{
"id": "split_0_train_9874_entity",
"type": "progene_text",
"text": [
"CD4"
],
"offsets": [
[
153,
156
]
],
"normalized": []
},
{
"id": "split_0_train_9875_entity",
"type": "progene_text",
"text": [
"CD8"
],
"offsets": [
[
167,
170
]
],
"normalized": []
},
{
"id": "split_0_train_9876_entity",
"type": "progene_text",
"text": [
"IL-12"
],
"offsets": [
[
203,
208
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6282
|
split_0_train_6282
|
[
{
"id": "split_0_train_6282_passage",
"type": "progene_text",
"text": [
"Engagement of CD40 on hapten - presenting Langerhans cells ( hpLC ) up - regulated the expression of both class I and class II MHC and promoted hpLC migration into the T cell priming site ."
],
"offsets": [
[
0,
189
]
]
}
] |
[
{
"id": "split_0_train_9877_entity",
"type": "progene_text",
"text": [
"CD40"
],
"offsets": [
[
14,
18
]
],
"normalized": []
},
{
"id": "split_0_train_9878_entity",
"type": "progene_text",
"text": [
"class I and class II MHC"
],
"offsets": [
[
106,
130
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6283
|
split_0_train_6283
|
[
{
"id": "split_0_train_6283_passage",
"type": "progene_text",
"text": [
"These results indicate that hpLC stimulated by CD40 ligation use a mechanism distinct from increased IL-12 production to promote Ag - specific T cell development to IFN-gamma - producing cells ."
],
"offsets": [
[
0,
194
]
]
}
] |
[
{
"id": "split_0_train_9879_entity",
"type": "progene_text",
"text": [
"CD40"
],
"offsets": [
[
47,
51
]
],
"normalized": []
},
{
"id": "split_0_train_9880_entity",
"type": "progene_text",
"text": [
"IL-12"
],
"offsets": [
[
101,
106
]
],
"normalized": []
},
{
"id": "split_0_train_9881_entity",
"type": "progene_text",
"text": [
"IFN-gamma"
],
"offsets": [
[
165,
174
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6284
|
split_0_train_6284
|
[
{
"id": "split_0_train_6284_passage",
"type": "progene_text",
"text": [
"Zinc stabilizes adenomatous polyposis coli ( APC ) protein levels and induces cell cycle arrest in colon cancer cells ."
],
"offsets": [
[
0,
119
]
]
}
] |
[
{
"id": "split_0_train_9882_entity",
"type": "progene_text",
"text": [
"adenomatous polyposis coli"
],
"offsets": [
[
16,
42
]
],
"normalized": []
},
{
"id": "split_0_train_9883_entity",
"type": "progene_text",
"text": [
"APC"
],
"offsets": [
[
45,
48
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6285
|
split_0_train_6285
|
[
{
"id": "split_0_train_6285_passage",
"type": "progene_text",
"text": [
"In the present study , we investigated the mechanisms by which zinc causes growth arrest in colon cancer cells ."
],
"offsets": [
[
0,
112
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6286
|
split_0_train_6286
|
[
{
"id": "split_0_train_6286_passage",
"type": "progene_text",
"text": [
"The results suggest that zinc treatment stabilizes the levels of the wild - type adenomatous polyposis coli ( APC ) protein at the post - translational level since the APC mRNA levels and the promoter activity of the APC gene were decreased in HCT-116 cells ( which express the wild - type APC gene ) after treatment with ZnCl2 ."
],
"offsets": [
[
0,
329
]
]
}
] |
[
{
"id": "split_0_train_9884_entity",
"type": "progene_text",
"text": [
"adenomatous polyposis coli"
],
"offsets": [
[
81,
107
]
],
"normalized": []
},
{
"id": "split_0_train_9885_entity",
"type": "progene_text",
"text": [
"APC"
],
"offsets": [
[
110,
113
]
],
"normalized": []
},
{
"id": "split_0_train_9886_entity",
"type": "progene_text",
"text": [
"APC"
],
"offsets": [
[
168,
171
]
],
"normalized": []
},
{
"id": "split_0_train_9887_entity",
"type": "progene_text",
"text": [
"APC"
],
"offsets": [
[
217,
220
]
],
"normalized": []
},
{
"id": "split_0_train_9888_entity",
"type": "progene_text",
"text": [
"APC"
],
"offsets": [
[
290,
293
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6287
|
split_0_train_6287
|
[
{
"id": "split_0_train_6287_passage",
"type": "progene_text",
"text": [
"Increased levels of wild - type but not truncated APC proteins were required for the ZnCl2 - mediated G2 / M phase arrest in different colon cancer cell lines ."
],
"offsets": [
[
0,
160
]
]
}
] |
[
{
"id": "split_0_train_9889_entity",
"type": "progene_text",
"text": [
"APC"
],
"offsets": [
[
50,
53
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6288
|
split_0_train_6288
|
[
{
"id": "split_0_train_6288_passage",
"type": "progene_text",
"text": [
"We further tested whether serum - stimulation , which induces cell cycle arrest in the S phase , can relieve ZnCl2 - induced G2/M phase arrest of HCT-116 cells ."
],
"offsets": [
[
0,
161
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6289
|
split_0_train_6289
|
[
{
"id": "split_0_train_6289_passage",
"type": "progene_text",
"text": [
"Results showed that in the HCT-116 cells pretreated with ZnCl2 , the serum - stimulation neither changed the distribution of G2 / M phase arrested cells nor the increased levels of APC protein ."
],
"offsets": [
[
0,
194
]
]
}
] |
[
{
"id": "split_0_train_9890_entity",
"type": "progene_text",
"text": [
"APC"
],
"offsets": [
[
181,
184
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6290
|
split_0_train_6290
|
[
{
"id": "split_0_train_6290_passage",
"type": "progene_text",
"text": [
"The G2 / M phase arrest correlated with retarded growth of HCT-116 cells ."
],
"offsets": [
[
0,
74
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6291
|
split_0_train_6291
|
[
{
"id": "split_0_train_6291_passage",
"type": "progene_text",
"text": [
"To further establish that wild - type APC protein plays a role in ZnCl2 - induced G2 / M arrest , we treated SW480 colon cancer cells that express truncated APC protein ."
],
"offsets": [
[
0,
170
]
]
}
] |
[
{
"id": "split_0_train_9891_entity",
"type": "progene_text",
"text": [
"APC"
],
"offsets": [
[
38,
41
]
],
"normalized": []
},
{
"id": "split_0_train_9892_entity",
"type": "progene_text",
"text": [
"APC"
],
"offsets": [
[
157,
160
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6292
|
split_0_train_6292
|
[
{
"id": "split_0_train_6292_passage",
"type": "progene_text",
"text": [
"We found that ZnCl2 treatment did not induce G2/M phase arrest in SW480 cells ; however , the cell growth was retarded due to the loss of E-cadherin and alpha-tubulin levels ."
],
"offsets": [
[
0,
175
]
]
}
] |
[
{
"id": "split_0_train_9893_entity",
"type": "progene_text",
"text": [
"E-cadherin"
],
"offsets": [
[
138,
148
]
],
"normalized": []
},
{
"id": "split_0_train_9894_entity",
"type": "progene_text",
"text": [
"alpha-tubulin"
],
"offsets": [
[
153,
166
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6293
|
split_0_train_6293
|
[
{
"id": "split_0_train_6293_passage",
"type": "progene_text",
"text": [
"These results suggest that ZnCl2 inhibits the proliferation of colon cancer cells ( which carry the wild - type APC gene ) through stabilization of the APC protein and cell cycle arrest in the G2 / M phase ."
],
"offsets": [
[
0,
207
]
]
}
] |
[
{
"id": "split_0_train_9895_entity",
"type": "progene_text",
"text": [
"APC"
],
"offsets": [
[
112,
115
]
],
"normalized": []
},
{
"id": "split_0_train_9896_entity",
"type": "progene_text",
"text": [
"APC"
],
"offsets": [
[
152,
155
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6294
|
split_0_train_6294
|
[
{
"id": "split_0_train_6294_passage",
"type": "progene_text",
"text": [
"On the other hand , ZnCl2 inhibits the proliferation of colon cancer cells ( which carry the mutant APC gene ) by disrupting cellular attachment and microtubule stability ."
],
"offsets": [
[
0,
172
]
]
}
] |
[
{
"id": "split_0_train_9897_entity",
"type": "progene_text",
"text": [
"APC"
],
"offsets": [
[
100,
103
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6295
|
split_0_train_6295
|
[
{
"id": "split_0_train_6295_passage",
"type": "progene_text",
"text": [
"Functional importance of Asp37 from a family 11 xylanase in the binding to two proteinaceous xylanase inhibitors from wheat ."
],
"offsets": [
[
0,
125
]
]
}
] |
[
{
"id": "split_0_train_9898_entity",
"type": "progene_text",
"text": [
"xylanase"
],
"offsets": [
[
48,
56
]
],
"normalized": []
},
{
"id": "split_0_train_9899_entity",
"type": "progene_text",
"text": [
"xylanase inhibitors"
],
"offsets": [
[
93,
112
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6296
|
split_0_train_6296
|
[
{
"id": "split_0_train_6296_passage",
"type": "progene_text",
"text": [
"Aspergillus niger xylanase is a target enzyme of the two wheat proteinaceous inhibitors , XIP-I and TAXI - I ."
],
"offsets": [
[
0,
110
]
]
}
] |
[
{
"id": "split_0_train_9900_entity",
"type": "progene_text",
"text": [
"xylanase"
],
"offsets": [
[
18,
26
]
],
"normalized": []
},
{
"id": "split_0_train_9901_entity",
"type": "progene_text",
"text": [
"XIP-I"
],
"offsets": [
[
90,
95
]
],
"normalized": []
},
{
"id": "split_0_train_9902_entity",
"type": "progene_text",
"text": [
"TAXI - I"
],
"offsets": [
[
100,
108
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6297
|
split_0_train_6297
|
[
{
"id": "split_0_train_6297_passage",
"type": "progene_text",
"text": [
"We previously suggested that the xylanase \" thumb \" region was XIP - I binding site ."
],
"offsets": [
[
0,
85
]
]
}
] |
[
{
"id": "split_0_train_9903_entity",
"type": "progene_text",
"text": [
"xylanase"
],
"offsets": [
[
33,
41
]
],
"normalized": []
},
{
"id": "split_0_train_9904_entity",
"type": "progene_text",
"text": [
"XIP - I"
],
"offsets": [
[
63,
70
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_6298
|
split_0_train_6298
|
[
{
"id": "split_0_train_6298_passage",
"type": "progene_text",
"text": [
"Here , we expressed the Asp37Ala mutant in Pichia pastoris and showed that the mutation abolished the enzyme capacity to interact with both inhibitors , suggesting a direct contact at the active site ."
],
"offsets": [
[
0,
201
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_6299
|
split_0_train_6299
|
[
{
"id": "split_0_train_6299_passage",
"type": "progene_text",
"text": [
"The mutant pH profile was altered , confirming the key role of Asp37 in determining the pH optima of glycoside hydrolase family 11 ."
],
"offsets": [
[
0,
132
]
]
}
] |
[
{
"id": "split_0_train_9905_entity",
"type": "progene_text",
"text": [
"glycoside hydrolase family 11"
],
"offsets": [
[
101,
130
]
],
"normalized": []
}
] |
[] |
[] |
[] |
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