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stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
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|---|---|---|---|---|---|---|
split_0_train_900 | split_0_train_900 | [
{
"id": "split_0_train_900_passage",
"type": "progene_text",
"text": [
"Using immunolocalization , we observe that ACE3 , a 440 - bp chorion element that contains information sufficient to drive amplification , directs DmORC localization in follicle cells ."
],
"offsets": [
[
0,
185
]
]
}
]
| [
{
"id": "split_0_train_1199_entity",
"type": "progene_text",
"text": [
"DmORC"
],
"offsets": [
[
147,
152
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_901 | split_0_train_901 | [
{
"id": "split_0_train_901_passage",
"type": "progene_text",
"text": [
"Similarly , in vivo cross - linking and chromatin immunoprecipitation assays demonstrate association of DmORC with both ACE3 and two other amplification control elements , AER-d and ACE1 ."
],
"offsets": [
[
0,
188
]
]
}
]
| [
{
"id": "split_0_train_1200_entity",
"type": "progene_text",
"text": [
"DmORC"
],
"offsets": [
[
104,
109
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_902 | split_0_train_902 | [
{
"id": "split_0_train_902_passage",
"type": "progene_text",
"text": [
"To demonstrate that the in vivo localization of DmORC is related to its DNA - binding properties , we find that purified DmORC binds to ACE3 and AER-d in vitro , and like its S. cerevisiae counterpart , this binding is dependent on ATP ."
],
"offsets": [
[
0,
237
]
]
}
]
| [
{
"id": "split_0_train_1201_entity",
"type": "progene_text",
"text": [
"DmORC"
],
"offsets": [
[
48,
53
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"normalized": []
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{
"id": "split_0_train_1202_entity",
"type": "progene_text",
"text": [
"DmORC"
],
"offsets": [
[
121,
126
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_903 | split_0_train_903 | [
{
"id": "split_0_train_903_passage",
"type": "progene_text",
"text": [
"Our findings suggest that sequence - specific DNA binding by ORC regulates initiation of metazoan DNA replication ."
],
"offsets": [
[
0,
115
]
]
}
]
| [
{
"id": "split_0_train_1203_entity",
"type": "progene_text",
"text": [
"ORC"
],
"offsets": [
[
61,
64
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_904 | split_0_train_904 | [
{
"id": "split_0_train_904_passage",
"type": "progene_text",
"text": [
"Furthermore , adaptation of this experimental approach will allow for the identification of additional metazoan ORC DNA - binding sites and potentially origins of replication ."
],
"offsets": [
[
0,
176
]
]
}
]
| [
{
"id": "split_0_train_1204_entity",
"type": "progene_text",
"text": [
"ORC"
],
"offsets": [
[
112,
115
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_905 | split_0_train_905 | [
{
"id": "split_0_train_905_passage",
"type": "progene_text",
"text": [
"A multiprotein complex consisting of the cellular coactivator p300 , AP-1 / ATF , as well as NF-kappaB is responsible for the activation of the mouse major histocompatibility class I ( H-2K(b) ) enhancer A ."
],
"offsets": [
[
0,
207
]
]
}
]
| [
{
"id": "split_0_train_1205_entity",
"type": "progene_text",
"text": [
"p300"
],
"offsets": [
[
62,
66
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],
"normalized": []
},
{
"id": "split_0_train_1206_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
69,
73
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],
"normalized": []
},
{
"id": "split_0_train_1207_entity",
"type": "progene_text",
"text": [
"ATF"
],
"offsets": [
[
76,
79
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],
"normalized": []
},
{
"id": "split_0_train_1208_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
],
"offsets": [
[
93,
102
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],
"normalized": []
},
{
"id": "split_0_train_1209_entity",
"type": "progene_text",
"text": [
"major histocompatibility class I"
],
"offsets": [
[
150,
182
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],
"normalized": []
},
{
"id": "split_0_train_1210_entity",
"type": "progene_text",
"text": [
"H-2K(b)"
],
"offsets": [
[
185,
192
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_906 | split_0_train_906 | [
{
"id": "split_0_train_906_passage",
"type": "progene_text",
"text": [
"Major histocompatibility complex ( MHC ) class I genes encode highly polymorphic antigens that play an essential role in a number of immunological processes ."
],
"offsets": [
[
0,
158
]
]
}
]
| [
{
"id": "split_0_train_1211_entity",
"type": "progene_text",
"text": [
"Major histocompatibility complex ( MHC ) class I"
],
"offsets": [
[
0,
48
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_907 | split_0_train_907 | [
{
"id": "split_0_train_907_passage",
"type": "progene_text",
"text": [
"Their expression is activated in response to a variety of signals and is mediated through several promoter elements among which the enhancer A is one of the key control regions ."
],
"offsets": [
[
0,
178
]
]
}
]
| []
| []
| []
| []
|
split_0_train_908 | split_0_train_908 | [
{
"id": "split_0_train_908_passage",
"type": "progene_text",
"text": [
"It contains binding sites for several transcription factors , for example : (i) a well - characterized binding site for rel / NF-kappaB transcription factors in its 3'-end ( the H2TF1 or kappaB1 element ) , (ii) a second kappaB site ( the kappaB2 element ) , which is located immediately adjacent 5' to the H2TF1 element and which is recognized by p65 / relA in the human HLA system , and (iii) an AP-1 / ATF recognition sequence in the 5' end ( EnA - TRE ) ."
],
"offsets": [
[
0,
459
]
]
}
]
| [
{
"id": "split_0_train_1212_entity",
"type": "progene_text",
"text": [
"transcription factors"
],
"offsets": [
[
38,
59
]
],
"normalized": []
},
{
"id": "split_0_train_1213_entity",
"type": "progene_text",
"text": [
"rel"
],
"offsets": [
[
120,
123
]
],
"normalized": []
},
{
"id": "split_0_train_1214_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
],
"offsets": [
[
126,
135
]
],
"normalized": []
},
{
"id": "split_0_train_1215_entity",
"type": "progene_text",
"text": [
"transcription factors"
],
"offsets": [
[
136,
157
]
],
"normalized": []
},
{
"id": "split_0_train_1216_entity",
"type": "progene_text",
"text": [
"H2TF1"
],
"offsets": [
[
178,
183
]
],
"normalized": []
},
{
"id": "split_0_train_1217_entity",
"type": "progene_text",
"text": [
"kappaB"
],
"offsets": [
[
221,
227
]
],
"normalized": []
},
{
"id": "split_0_train_1218_entity",
"type": "progene_text",
"text": [
"H2TF1"
],
"offsets": [
[
307,
312
]
],
"normalized": []
},
{
"id": "split_0_train_1219_entity",
"type": "progene_text",
"text": [
"p65 / relA"
],
"offsets": [
[
348,
358
]
],
"normalized": []
},
{
"id": "split_0_train_1220_entity",
"type": "progene_text",
"text": [
"HLA"
],
"offsets": [
[
372,
375
]
],
"normalized": []
},
{
"id": "split_0_train_1221_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
398,
402
]
],
"normalized": []
},
{
"id": "split_0_train_1222_entity",
"type": "progene_text",
"text": [
"ATF"
],
"offsets": [
[
405,
408
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_909 | split_0_train_909 | [
{
"id": "split_0_train_909_passage",
"type": "progene_text",
"text": [
"Here we demonstrate that latter element is bound by at least two distinct heterodimers of the AP-1 / ATF transcription factor family , namely c-Jun / ATF - 2 and c-Jun / Fra2 ."
],
"offsets": [
[
0,
176
]
]
}
]
| [
{
"id": "split_0_train_1223_entity",
"type": "progene_text",
"text": [
"AP-1 / ATF transcription factor family"
],
"offsets": [
[
94,
132
]
],
"normalized": []
},
{
"id": "split_0_train_1224_entity",
"type": "progene_text",
"text": [
"c-Jun"
],
"offsets": [
[
142,
147
]
],
"normalized": []
},
{
"id": "split_0_train_1225_entity",
"type": "progene_text",
"text": [
"ATF - 2"
],
"offsets": [
[
150,
157
]
],
"normalized": []
},
{
"id": "split_0_train_1226_entity",
"type": "progene_text",
"text": [
"c-Jun"
],
"offsets": [
[
162,
167
]
],
"normalized": []
},
{
"id": "split_0_train_1227_entity",
"type": "progene_text",
"text": [
"Fra2"
],
"offsets": [
[
170,
174
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_910 | split_0_train_910 | [
{
"id": "split_0_train_910_passage",
"type": "progene_text",
"text": [
"Moreover , our data reveal that the enhancer A is simultaneously bound by AP-1 / ATF and rel / NF-kappaB transcription factors and that the cellular coactivator p300 , which enhances enhancer A-driven reporter gene expression if cotransfected , is recruited to the enhancer A through this multiprotein complex ."
],
"offsets": [
[
0,
311
]
]
}
]
| [
{
"id": "split_0_train_1228_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
74,
78
]
],
"normalized": []
},
{
"id": "split_0_train_1229_entity",
"type": "progene_text",
"text": [
"ATF"
],
"offsets": [
[
81,
84
]
],
"normalized": []
},
{
"id": "split_0_train_1230_entity",
"type": "progene_text",
"text": [
"rel"
],
"offsets": [
[
89,
92
]
],
"normalized": []
},
{
"id": "split_0_train_1231_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
],
"offsets": [
[
95,
104
]
],
"normalized": []
},
{
"id": "split_0_train_1232_entity",
"type": "progene_text",
"text": [
"transcription factors"
],
"offsets": [
[
105,
126
]
],
"normalized": []
},
{
"id": "split_0_train_1233_entity",
"type": "progene_text",
"text": [
"p300"
],
"offsets": [
[
161,
165
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_911 | split_0_train_911 | [
{
"id": "split_0_train_911_passage",
"type": "progene_text",
"text": [
"In contrast to the complete enhancer A , neither the EnA-TRE nor the H2TF1 element on their own are able to confer activation on a heterologous promoter in response to the phorbol ester tumor promoter TPA or the cytokine TNFalpha ."
],
"offsets": [
[
0,
231
]
]
}
]
| [
{
"id": "split_0_train_1234_entity",
"type": "progene_text",
"text": [
"H2TF1"
],
"offsets": [
[
69,
74
]
],
"normalized": []
},
{
"id": "split_0_train_1235_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
212,
220
]
],
"normalized": []
},
{
"id": "split_0_train_1236_entity",
"type": "progene_text",
"text": [
"TNFalpha"
],
"offsets": [
[
221,
229
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_912 | split_0_train_912 | [
{
"id": "split_0_train_912_passage",
"type": "progene_text",
"text": [
"Moreover , deletion of any one of the enhancer A control elements results in a dramatic loss of its inducibility by TNFalpha , and point mutations in either the EnA-TRE or the H2TF1 element lead to the loss of AP-1 / ATF or NF-kappaB binding , respectively , and to the loss of enhancer A inducibility ."
],
"offsets": [
[
0,
303
]
]
}
]
| [
{
"id": "split_0_train_1237_entity",
"type": "progene_text",
"text": [
"TNFalpha"
],
"offsets": [
[
116,
124
]
],
"normalized": []
},
{
"id": "split_0_train_1238_entity",
"type": "progene_text",
"text": [
"H2TF1"
],
"offsets": [
[
176,
181
]
],
"normalized": []
},
{
"id": "split_0_train_1239_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
210,
214
]
],
"normalized": []
},
{
"id": "split_0_train_1240_entity",
"type": "progene_text",
"text": [
"ATF"
],
"offsets": [
[
217,
220
]
],
"normalized": []
},
{
"id": "split_0_train_1241_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
],
"offsets": [
[
224,
233
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_913 | split_0_train_913 | [
{
"id": "split_0_train_913_passage",
"type": "progene_text",
"text": [
"Therefore , we conclude that the enhancer A is synergistically activated through a multiprotein complex containing AP-1 / ATF , NF-kappaB transcription factors as well as the cellular coactivator p300 ."
],
"offsets": [
[
0,
202
]
]
}
]
| [
{
"id": "split_0_train_1242_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
115,
119
]
],
"normalized": []
},
{
"id": "split_0_train_1243_entity",
"type": "progene_text",
"text": [
"ATF"
],
"offsets": [
[
122,
125
]
],
"normalized": []
},
{
"id": "split_0_train_1244_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
],
"offsets": [
[
128,
137
]
],
"normalized": []
},
{
"id": "split_0_train_1245_entity",
"type": "progene_text",
"text": [
"transcription factors"
],
"offsets": [
[
138,
159
]
],
"normalized": []
},
{
"id": "split_0_train_1246_entity",
"type": "progene_text",
"text": [
"p300"
],
"offsets": [
[
196,
200
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_914 | split_0_train_914 | [
{
"id": "split_0_train_914_passage",
"type": "progene_text",
"text": [
"Heterologous gene expression in a membrane - protein - specific system ."
],
"offsets": [
[
0,
72
]
]
}
]
| []
| []
| []
| []
|
split_0_train_915 | split_0_train_915 | [
{
"id": "split_0_train_915_passage",
"type": "progene_text",
"text": [
"We have constructed an expression system for heterologous proteins which uses the molecular machinery responsible for the high level production of bacteriorhodopsin in Halobacterium salinarum ."
],
"offsets": [
[
0,
193
]
]
}
]
| [
{
"id": "split_0_train_1247_entity",
"type": "progene_text",
"text": [
"bacteriorhodopsin"
],
"offsets": [
[
147,
164
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_916 | split_0_train_916 | [
{
"id": "split_0_train_916_passage",
"type": "progene_text",
"text": [
"Cloning vectors were assembled that fused sequences of the bacterio - opsin gene ( bop ) to coding sequences of heterologous genes and generated DNA fragments with cloning sites that permitted transfer of fused genes into H. salinarum expression vectors ."
],
"offsets": [
[
0,
255
]
]
}
]
| [
{
"id": "split_0_train_1248_entity",
"type": "progene_text",
"text": [
"bacterio - opsin"
],
"offsets": [
[
59,
75
]
],
"normalized": []
},
{
"id": "split_0_train_1249_entity",
"type": "progene_text",
"text": [
"bop"
],
"offsets": [
[
83,
86
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_917 | split_0_train_917 | [
{
"id": "split_0_train_917_passage",
"type": "progene_text",
"text": [
"Gene fusions include : (i) carboxyl - terminal - tagged bacterio - opsin ; (ii) a carboxyl - terminal fusion with the catalytic subunit of the Escherichia coli aspartate transcarbamylase ; (iii) the human muscarinic receptor , subtype M1 ; (iv) the human serotonin receptor , type 5HT2c ; and (v) the yeast alpha mating factor receptor , Ste2 ."
],
"offsets": [
[
0,
344
]
]
}
]
| [
{
"id": "split_0_train_1250_entity",
"type": "progene_text",
"text": [
"bacterio - opsin"
],
"offsets": [
[
56,
72
]
],
"normalized": []
},
{
"id": "split_0_train_1251_entity",
"type": "progene_text",
"text": [
"aspartate transcarbamylase"
],
"offsets": [
[
160,
186
]
],
"normalized": []
},
{
"id": "split_0_train_1252_entity",
"type": "progene_text",
"text": [
"muscarinic receptor , subtype M1"
],
"offsets": [
[
205,
237
]
],
"normalized": []
},
{
"id": "split_0_train_1253_entity",
"type": "progene_text",
"text": [
"serotonin receptor , type 5HT2c"
],
"offsets": [
[
255,
286
]
],
"normalized": []
},
{
"id": "split_0_train_1254_entity",
"type": "progene_text",
"text": [
"alpha mating factor receptor"
],
"offsets": [
[
307,
335
]
],
"normalized": []
},
{
"id": "split_0_train_1255_entity",
"type": "progene_text",
"text": [
"Ste2"
],
"offsets": [
[
338,
342
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_918 | split_0_train_918 | [
{
"id": "split_0_train_918_passage",
"type": "progene_text",
"text": [
"Characterization of the expression of these fusions revealed that the bop gene coding region contains previously undescribed molecular determinants which are critical for high level expression ."
],
"offsets": [
[
0,
194
]
]
}
]
| []
| []
| []
| []
|
split_0_train_919 | split_0_train_919 | [
{
"id": "split_0_train_919_passage",
"type": "progene_text",
"text": [
"For example , introduction of immunogenic and purification tag sequences into the C - terminal coding region significantly decreased bop gene mRNA and protein accumulation ."
],
"offsets": [
[
0,
173
]
]
}
]
| [
{
"id": "split_0_train_1256_entity",
"type": "progene_text",
"text": [
"bop"
],
"offsets": [
[
133,
136
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_920 | split_0_train_920 | [
{
"id": "split_0_train_920_passage",
"type": "progene_text",
"text": [
"The bacteriorhodopsin - aspartate transcarbamylase fusion protein was expressed at 7 mg per liter of culture , demonstrating that E. coli codon usage bias did not limit the system 's potential for high level expression ."
],
"offsets": [
[
0,
220
]
]
}
]
| [
{
"id": "split_0_train_1257_entity",
"type": "progene_text",
"text": [
"bacteriorhodopsin"
],
"offsets": [
[
4,
21
]
],
"normalized": []
},
{
"id": "split_0_train_1258_entity",
"type": "progene_text",
"text": [
"aspartate transcarbamylase"
],
"offsets": [
[
24,
50
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_921 | split_0_train_921 | [
{
"id": "split_0_train_921_passage",
"type": "progene_text",
"text": [
"The work presented describes initial efforts in the development of a novel heterologous protein expression system , which may have unique advantages for producing multiple milligram quantities of membrane - associated proteins ."
],
"offsets": [
[
0,
228
]
]
}
]
| []
| []
| []
| []
|
split_0_train_922 | split_0_train_922 | [
{
"id": "split_0_train_922_passage",
"type": "progene_text",
"text": [
"Regulation of HIV-1 transcription ."
],
"offsets": [
[
0,
35
]
]
}
]
| []
| []
| []
| []
|
split_0_train_923 | split_0_train_923 | [
{
"id": "split_0_train_923_passage",
"type": "progene_text",
"text": [
"Human immunodeficiency virus type-1 ( HIV-1 ) is a highly pathogenic lentivirus that requires transcription of its provirus genome for completion of the viral life cycle and the production of progeny virions ."
],
"offsets": [
[
0,
209
]
]
}
]
| []
| []
| []
| []
|
split_0_train_924 | split_0_train_924 | [
{
"id": "split_0_train_924_passage",
"type": "progene_text",
"text": [
"Since the first genetic analysis of HIV-1 in 1985 , much has been learned about the transcriptional regulation of the HIV-1 genome in infected cells ."
],
"offsets": [
[
0,
150
]
]
}
]
| []
| []
| []
| []
|
split_0_train_925 | split_0_train_925 | [
{
"id": "split_0_train_925_passage",
"type": "progene_text",
"text": [
"It has been demonstrated that HIV-1 transcription depends on a varied and complex interaction of host cell transcription factors with the viral long terminal repeat ( LTR ) promoter ."
],
"offsets": [
[
0,
183
]
]
}
]
| [
{
"id": "split_0_train_1259_entity",
"type": "progene_text",
"text": [
"transcription factors"
],
"offsets": [
[
107,
128
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_926 | split_0_train_926 | [
{
"id": "split_0_train_926_passage",
"type": "progene_text",
"text": [
"The regulatory elements within the LTR interact with constitutive and inducible transcription factors to direct the assembly of a stable transcription complex that stimulates multiple rounds of transcription by RNA polymerase II ( RNAPII ) ."
],
"offsets": [
[
0,
241
]
]
}
]
| [
{
"id": "split_0_train_1260_entity",
"type": "progene_text",
"text": [
"RNA polymerase II"
],
"offsets": [
[
211,
228
]
],
"normalized": []
},
{
"id": "split_0_train_1261_entity",
"type": "progene_text",
"text": [
"RNAPII"
],
"offsets": [
[
231,
237
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_927 | split_0_train_927 | [
{
"id": "split_0_train_927_passage",
"type": "progene_text",
"text": [
"However , the majority of these transcripts terminate prematurely in the absence of the virally encoded trans - activator protein Tat , which stimulates HIV-1 transcription elongation by interacting with a stem - loop RNA element ( TAR ) formed at the extreme 5' end of all viral transcripts ."
],
"offsets": [
[
0,
293
]
]
}
]
| [
{
"id": "split_0_train_1262_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
130,
133
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_928 | split_0_train_928 | [
{
"id": "split_0_train_928_passage",
"type": "progene_text",
"text": [
"The Tat - TAR interaction recruits a cellular kinase into the initiation - elongation complex that alters the elongation properties of RNAPII during its transit through TAR ."
],
"offsets": [
[
0,
174
]
]
}
]
| [
{
"id": "split_0_train_1263_entity",
"type": "progene_text",
"text": [
"Tat"
],
"offsets": [
[
4,
7
]
],
"normalized": []
},
{
"id": "split_0_train_1264_entity",
"type": "progene_text",
"text": [
"kinase"
],
"offsets": [
[
46,
52
]
],
"normalized": []
},
{
"id": "split_0_train_1265_entity",
"type": "progene_text",
"text": [
"RNAPII"
],
"offsets": [
[
135,
141
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_929 | split_0_train_929 | [
{
"id": "split_0_train_929_passage",
"type": "progene_text",
"text": [
"This review summarizes our current knowledge and understanding of the regulation of HIV-1 transcription in infected cells and highlights the important contributions human lentivirus gene regulation has made to our general understanding of the transcription process ."
],
"offsets": [
[
0,
266
]
]
}
]
| []
| []
| []
| []
|
split_0_train_930 | split_0_train_930 | [
{
"id": "split_0_train_930_passage",
"type": "progene_text",
"text": [
"Modern antioestrogens and the coming revolution in women 's health care ."
],
"offsets": [
[
0,
73
]
]
}
]
| []
| []
| []
| []
|
split_0_train_931 | split_0_train_931 | [
{
"id": "split_0_train_931_passage",
"type": "progene_text",
"text": [
"This review will focus on antioestrogens and selective oestrogen receptor modulators ( SERMS ) ."
],
"offsets": [
[
0,
96
]
]
}
]
| [
{
"id": "split_0_train_1266_entity",
"type": "progene_text",
"text": [
"oestrogen receptor"
],
"offsets": [
[
55,
73
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_932 | split_0_train_932 | [
{
"id": "split_0_train_932_passage",
"type": "progene_text",
"text": [
"The more traditional SERMS , clomiphene citrate and tamoxifen , will be reviewed along with such modern drugs as raloxifene and faslodex , with emphasis upon their actions on breast , uterus , bone and lipids ."
],
"offsets": [
[
0,
210
]
]
}
]
| []
| []
| []
| []
|
split_0_train_933 | split_0_train_933 | [
{
"id": "split_0_train_933_passage",
"type": "progene_text",
"text": [
"The future potential of these medications , in the management of oestrogen - dependent gynaecological conditions such as endometriosis , dysfunctional uterine bleeding , fibroids and breast cancer will be discussed ."
],
"offsets": [
[
0,
216
]
]
}
]
| []
| []
| []
| []
|
split_0_train_934 | split_0_train_934 | [
{
"id": "split_0_train_934_passage",
"type": "progene_text",
"text": [
"ETR-1 , a homologue of a protein linked to myotonic dystrophy , is essential for muscle development in Caenorhabditis elegans ."
],
"offsets": [
[
0,
127
]
]
}
]
| [
{
"id": "split_0_train_1267_entity",
"type": "progene_text",
"text": [
"ETR-1"
],
"offsets": [
[
0,
5
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_935 | split_0_train_935 | [
{
"id": "split_0_train_935_passage",
"type": "progene_text",
"text": [
"Post - transcriptional gene processing by RNA - binding proteins ( RBPs ) has crucial roles during development [ 1 ] [ 2 ] ."
],
"offsets": [
[
0,
124
]
]
}
]
| []
| []
| []
| []
|
split_0_train_936 | split_0_train_936 | [
{
"id": "split_0_train_936_passage",
"type": "progene_text",
"text": [
"Here , we report the identification of ETR-1 ( ELAV - type RNA - binding protein ) , a muscle - specific RBP in the nematode Caenorhabditis elegans ."
],
"offsets": [
[
0,
149
]
]
}
]
| [
{
"id": "split_0_train_1268_entity",
"type": "progene_text",
"text": [
"ETR-1"
],
"offsets": [
[
39,
44
]
],
"normalized": []
},
{
"id": "split_0_train_1269_entity",
"type": "progene_text",
"text": [
"ELAV - type RNA - binding protein"
],
"offsets": [
[
47,
80
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_937 | split_0_train_937 | [
{
"id": "split_0_train_937_passage",
"type": "progene_text",
"text": [
"ETR-1 is related to the family of RBPs defined by the protein ELAV , which is essential for neurogenesis in the fruit fly Drosophila ; members of the family possess two consecutive RNA recognition motifs ( RRMs ) separated from a third , carboxy - terminal RRM by a tether region of variable length [3] [4] [5] [6] ."
],
"offsets": [
[
0,
316
]
]
}
]
| [
{
"id": "split_0_train_1270_entity",
"type": "progene_text",
"text": [
"ETR-1"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "split_0_train_1271_entity",
"type": "progene_text",
"text": [
"ELAV"
],
"offsets": [
[
62,
66
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_938 | split_0_train_938 | [
{
"id": "split_0_train_938_passage",
"type": "progene_text",
"text": [
"Its closest homologue , CUG - binding protein ( CUG - bp ) , is a human RBP that has been implicated in the disease myotonic dystrophy and binds CUG repeats in the 3' untranslated region ( UTR ) of the mRNA for myotonic dystrophy protein kinase ( DMPK ) [ 7 ] [ 8 ] ."
],
"offsets": [
[
0,
267
]
]
}
]
| [
{
"id": "split_0_train_1272_entity",
"type": "progene_text",
"text": [
"CUG - binding protein"
],
"offsets": [
[
24,
45
]
],
"normalized": []
},
{
"id": "split_0_train_1273_entity",
"type": "progene_text",
"text": [
"CUG - bp"
],
"offsets": [
[
48,
56
]
],
"normalized": []
},
{
"id": "split_0_train_1274_entity",
"type": "progene_text",
"text": [
"myotonic dystrophy protein kinase"
],
"offsets": [
[
211,
244
]
],
"normalized": []
},
{
"id": "split_0_train_1275_entity",
"type": "progene_text",
"text": [
"DMPK"
],
"offsets": [
[
247,
251
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_939 | split_0_train_939 | [
{
"id": "split_0_train_939_passage",
"type": "progene_text",
"text": [
"Inactivation of etr-1 by RNA - mediated interference resulted in embryonic lethality ."
],
"offsets": [
[
0,
86
]
]
}
]
| [
{
"id": "split_0_train_1276_entity",
"type": "progene_text",
"text": [
"etr-1"
],
"offsets": [
[
16,
21
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_940 | split_0_train_940 | [
{
"id": "split_0_train_940_passage",
"type": "progene_text",
"text": [
"Embryos failed to elongate and became paralysed , a phenotype characteristic of C. elegans Pat mutants , which are defective in muscle formation and function [ 9 ] ."
],
"offsets": [
[
0,
165
]
]
}
]
| [
{
"id": "split_0_train_1277_entity",
"type": "progene_text",
"text": [
"Pat"
],
"offsets": [
[
91,
94
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_941 | split_0_train_941 | [
{
"id": "split_0_train_941_passage",
"type": "progene_text",
"text": [
"The data indicate that etr-1 is essential for muscle development in C. elegans , perhaps by playing a role in post - transcriptional processing of some muscle component , and thus suggesting a possible conservation of gene function with human CUG - bp ."
],
"offsets": [
[
0,
253
]
]
}
]
| [
{
"id": "split_0_train_1278_entity",
"type": "progene_text",
"text": [
"etr-1"
],
"offsets": [
[
23,
28
]
],
"normalized": []
},
{
"id": "split_0_train_1279_entity",
"type": "progene_text",
"text": [
"CUG - bp"
],
"offsets": [
[
243,
251
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_942 | split_0_train_942 | [
{
"id": "split_0_train_942_passage",
"type": "progene_text",
"text": [
"Putative RNA capping activities encoded by brome mosaic virus : methylation and covalent binding of guanylate by replicase protein 1a ."
],
"offsets": [
[
0,
135
]
]
}
]
| [
{
"id": "split_0_train_1280_entity",
"type": "progene_text",
"text": [
"replicase protein 1a"
],
"offsets": [
[
113,
133
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_943 | split_0_train_943 | [
{
"id": "split_0_train_943_passage",
"type": "progene_text",
"text": [
"Brome mosaic virus ( BMV ) RNA replication is directed by two virus - encoded proteins , 1a and 2a ."
],
"offsets": [
[
0,
100
]
]
}
]
| []
| []
| []
| []
|
split_0_train_944 | split_0_train_944 | [
{
"id": "split_0_train_944_passage",
"type": "progene_text",
"text": [
"The amino - terminal half of 1a is a distant homolog of alphavirus nonstructural protein nsP1 , which has been implicated in capping viral RNAs ."
],
"offsets": [
[
0,
145
]
]
}
]
| [
{
"id": "split_0_train_1281_entity",
"type": "progene_text",
"text": [
"nonstructural protein"
],
"offsets": [
[
67,
88
]
],
"normalized": []
},
{
"id": "split_0_train_1282_entity",
"type": "progene_text",
"text": [
"nsP1"
],
"offsets": [
[
89,
93
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_945 | split_0_train_945 | [
{
"id": "split_0_train_945_passage",
"type": "progene_text",
"text": [
"In this study , we examined the enzymatic activities of BMV 1a expressed in yeast , where the protein is fully functional in RNA replication ."
],
"offsets": [
[
0,
142
]
]
}
]
| []
| []
| []
| []
|
split_0_train_946 | split_0_train_946 | [
{
"id": "split_0_train_946_passage",
"type": "progene_text",
"text": [
"1a methylated GTP , dGTP , and the cap analogs GpppG and GpppA , using S-adenosylmethionine ( AdoMet ) as the methyl donor ."
],
"offsets": [
[
0,
124
]
]
}
]
| []
| []
| []
| []
|
split_0_train_947 | split_0_train_947 | [
{
"id": "split_0_train_947_passage",
"type": "progene_text",
"text": [
"Product analysis by nuclear magnetic resonance spectroscopy showed that 1a methylation was specific for guanine position 7 ."
],
"offsets": [
[
0,
124
]
]
}
]
| []
| []
| []
| []
|
split_0_train_948 | split_0_train_948 | [
{
"id": "split_0_train_948_passage",
"type": "progene_text",
"text": [
"Additionally , 1a interacted with GTP to form a covalent 1a-m(7) GMP complex ."
],
"offsets": [
[
0,
78
]
]
}
]
| []
| []
| []
| []
|
split_0_train_949 | split_0_train_949 | [
{
"id": "split_0_train_949_passage",
"type": "progene_text",
"text": [
"This reaction was specific for GTP , required AdoMet , and was accompanied by transfer of (3)H-methyl from AdoMet to the covalent 1a - guanylate complex ."
],
"offsets": [
[
0,
154
]
]
}
]
| []
| []
| []
| []
|
split_0_train_950 | split_0_train_950 | [
{
"id": "split_0_train_950_passage",
"type": "progene_text",
"text": [
"The covalent complex could be immunoprecipitated by 1a antibodies ."
],
"offsets": [
[
0,
67
]
]
}
]
| []
| []
| []
| []
|
split_0_train_951 | split_0_train_951 | [
{
"id": "split_0_train_951_passage",
"type": "progene_text",
"text": [
"The 1a-m(7) GMP complex was inhibited in catalyzing further methyltransferase reactions ."
],
"offsets": [
[
0,
89
]
]
}
]
| [
{
"id": "split_0_train_1283_entity",
"type": "progene_text",
"text": [
"methyltransferase"
],
"offsets": [
[
60,
77
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_952 | split_0_train_952 | [
{
"id": "split_0_train_952_passage",
"type": "progene_text",
"text": [
"Mutation of conserved amino acids in the N - terminal half of 1a reduced both methyltransferase and covalent complex formation activities to very low or undetectable levels ."
],
"offsets": [
[
0,
174
]
]
}
]
| [
{
"id": "split_0_train_1284_entity",
"type": "progene_text",
"text": [
"methyltransferase"
],
"offsets": [
[
78,
95
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_953 | split_0_train_953 | [
{
"id": "split_0_train_953_passage",
"type": "progene_text",
"text": [
"Covalent 1a-guanylate complex formation took place in similar , AdoMet - dependent fashion in extracts of BMV - infected barley protoplasts ."
],
"offsets": [
[
0,
141
]
]
}
]
| []
| []
| []
| []
|
split_0_train_954 | split_0_train_954 | [
{
"id": "split_0_train_954_passage",
"type": "progene_text",
"text": [
"These results show that BMV 1a has activities similar to those of alphavirus nsP1 , demonstrating conservation of these putative capping functions across a wide span of sequence divergence within the alphavirus - like superfamily ."
],
"offsets": [
[
0,
231
]
]
}
]
| [
{
"id": "split_0_train_1285_entity",
"type": "progene_text",
"text": [
"nsP1"
],
"offsets": [
[
77,
81
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_955 | split_0_train_955 | [
{
"id": "split_0_train_955_passage",
"type": "progene_text",
"text": [
"Conservation of this unusual combination of functions also supports the inference that the superfamily caps viral RNAs by an unusual pathway proceeding via a m(7)GMP intermediate ."
],
"offsets": [
[
0,
180
]
]
}
]
| []
| []
| []
| []
|
split_0_train_956 | split_0_train_956 | [
{
"id": "split_0_train_956_passage",
"type": "progene_text",
"text": [
"Ectopic expression of protein kinase CbetaII , - delta , and - epsilon , but not - betaI or - zeta , provide for insulin stimulation of glucose uptake in NIH-3T3 cells ."
],
"offsets": [
[
0,
169
]
]
}
]
| [
{
"id": "split_0_train_1286_entity",
"type": "progene_text",
"text": [
"protein kinase CbetaII , - delta , and - epsilon , but not - betaI or - zeta"
],
"offsets": [
[
22,
98
]
],
"normalized": []
},
{
"id": "split_0_train_1287_entity",
"type": "progene_text",
"text": [
"insulin"
],
"offsets": [
[
113,
120
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_957 | split_0_train_957 | [
{
"id": "split_0_train_957_passage",
"type": "progene_text",
"text": [
"Insulin regulates a diverse array of signaling pathways involved in the control of growth , differentiation , proliferation , and metabolism ."
],
"offsets": [
[
0,
142
]
]
}
]
| [
{
"id": "split_0_train_1288_entity",
"type": "progene_text",
"text": [
"Insulin"
],
"offsets": [
[
0,
7
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_958 | split_0_train_958 | [
{
"id": "split_0_train_958_passage",
"type": "progene_text",
"text": [
"Insulin increases in glucose uptake via a protein kinase C - dependent pathway in target tissues such as fat and muscle are well documented ."
],
"offsets": [
[
0,
141
]
]
}
]
| [
{
"id": "split_0_train_1289_entity",
"type": "progene_text",
"text": [
"Insulin"
],
"offsets": [
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0,
7
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{
"id": "split_0_train_1290_entity",
"type": "progene_text",
"text": [
"protein kinase C"
],
"offsets": [
[
42,
58
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_959 | split_0_train_959 | [
{
"id": "split_0_train_959_passage",
"type": "progene_text",
"text": [
"Insulin - regulated events , however , occur in all cells ."
],
"offsets": [
[
0,
59
]
]
}
]
| [
{
"id": "split_0_train_1291_entity",
"type": "progene_text",
"text": [
"Insulin"
],
"offsets": [
[
0,
7
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_960 | split_0_train_960 | [
{
"id": "split_0_train_960_passage",
"type": "progene_text",
"text": [
"The utilization of glucose as a preferred energy source is a ubiquitous event in eukaryotic cells ."
],
"offsets": [
[
0,
99
]
]
}
]
| []
| []
| []
| []
|
split_0_train_961 | split_0_train_961 | [
{
"id": "split_0_train_961_passage",
"type": "progene_text",
"text": [
"In NIH-3T3 fibroblasts , insulin treatment increased levels of the cPKC and nPKC activator , diacylglycerol ."
],
"offsets": [
[
0,
109
]
]
}
]
| [
{
"id": "split_0_train_1292_entity",
"type": "progene_text",
"text": [
"insulin"
],
"offsets": [
[
25,
32
]
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},
{
"id": "split_0_train_1293_entity",
"type": "progene_text",
"text": [
"cPKC"
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[
67,
71
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],
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},
{
"id": "split_0_train_1294_entity",
"type": "progene_text",
"text": [
"nPKC"
],
"offsets": [
[
76,
80
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_962 | split_0_train_962 | [
{
"id": "split_0_train_962_passage",
"type": "progene_text",
"text": [
"Insulin - responsive 2-[(3)H]deoxyglucose uptake was stimulated in a dose - dependent manner ."
],
"offsets": [
[
0,
94
]
]
}
]
| [
{
"id": "split_0_train_1295_entity",
"type": "progene_text",
"text": [
"Insulin"
],
"offsets": [
[
0,
7
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_963 | split_0_train_963 | [
{
"id": "split_0_train_963_passage",
"type": "progene_text",
"text": [
"The overexpression of protein kinase C ( PKC ) betaI , - betaII , - delta , - epsilon , and - zeta was used to investigate the specificity of PKC isozymes for insulin - sensitive glucose uptake ."
],
"offsets": [
[
0,
195
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]
}
]
| [
{
"id": "split_0_train_1296_entity",
"type": "progene_text",
"text": [
"protein kinase C ( PKC ) betaI , - betaII , - delta , - epsilon , and - zeta"
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22,
98
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{
"id": "split_0_train_1297_entity",
"type": "progene_text",
"text": [
"PKC"
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[
142,
145
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},
{
"id": "split_0_train_1298_entity",
"type": "progene_text",
"text": [
"insulin"
],
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[
159,
166
]
],
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}
]
| []
| []
| []
|
split_0_train_964 | split_0_train_964 | [
{
"id": "split_0_train_964_passage",
"type": "progene_text",
"text": [
"The stable overexpression of PKCbetaII , - delta , and - epsilon resulted in increases in insulin - stimulated 2-[(3)H]deoxyglucose uptake compared to vector control cells , while basal 2-deoxyglucose uptake levels were not elevated ."
],
"offsets": [
[
0,
234
]
]
}
]
| [
{
"id": "split_0_train_1299_entity",
"type": "progene_text",
"text": [
"PKCbetaII , - delta , and - epsilon"
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[
29,
64
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],
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},
{
"id": "split_0_train_1300_entity",
"type": "progene_text",
"text": [
"insulin"
],
"offsets": [
[
90,
97
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_965 | split_0_train_965 | [
{
"id": "split_0_train_965_passage",
"type": "progene_text",
"text": [
"Overexpression of PKCbetaI and PKCzeta isozymes had no further effect on basal or insulin - stimulated 2-deoxyglucose uptake ."
],
"offsets": [
[
0,
126
]
]
}
]
| [
{
"id": "split_0_train_1301_entity",
"type": "progene_text",
"text": [
"PKCbetaI"
],
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[
18,
26
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],
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},
{
"id": "split_0_train_1302_entity",
"type": "progene_text",
"text": [
"PKCzeta"
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[
31,
38
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],
"normalized": []
},
{
"id": "split_0_train_1303_entity",
"type": "progene_text",
"text": [
"insulin"
],
"offsets": [
[
82,
89
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_966 | split_0_train_966 | [
{
"id": "split_0_train_966_passage",
"type": "progene_text",
"text": [
"The PKC - specific inhibitor , CGP41251 , blocked insulin effects on 2-deoxyglucose uptake but not its effects on tyrosine phosphorylation of cellular substrates ."
],
"offsets": [
[
0,
163
]
]
}
]
| [
{
"id": "split_0_train_1304_entity",
"type": "progene_text",
"text": [
"PKC"
],
"offsets": [
[
4,
7
]
],
"normalized": []
},
{
"id": "split_0_train_1305_entity",
"type": "progene_text",
"text": [
"insulin"
],
"offsets": [
[
50,
57
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_967 | split_0_train_967 | [
{
"id": "split_0_train_967_passage",
"type": "progene_text",
"text": [
"Insulin - stimulated 3-O-methylglucose uptake was also greater in cells overexpressing PKCbetaII , - delta , and - epsilon , compared to control cells ."
],
"offsets": [
[
0,
152
]
]
}
]
| [
{
"id": "split_0_train_1306_entity",
"type": "progene_text",
"text": [
"Insulin"
],
"offsets": [
[
0,
7
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],
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},
{
"id": "split_0_train_1307_entity",
"type": "progene_text",
"text": [
"PKCbetaII , - delta , and - epsilon"
],
"offsets": [
[
87,
122
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_968 | split_0_train_968 | [
{
"id": "split_0_train_968_passage",
"type": "progene_text",
"text": [
"The increased responsiveness was not accompanied by conversion of 3T3 cells to the adipocyte phenotype or the increased expression of insulin receptors or glucose transporters ( GLUT1 - type ) ."
],
"offsets": [
[
0,
194
]
]
}
]
| [
{
"id": "split_0_train_1308_entity",
"type": "progene_text",
"text": [
"insulin receptors"
],
"offsets": [
[
134,
151
]
],
"normalized": []
},
{
"id": "split_0_train_1309_entity",
"type": "progene_text",
"text": [
"glucose transporters"
],
"offsets": [
[
155,
175
]
],
"normalized": []
},
{
"id": "split_0_train_1310_entity",
"type": "progene_text",
"text": [
"GLUT1"
],
"offsets": [
[
178,
183
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_969 | split_0_train_969 | [
{
"id": "split_0_train_969_passage",
"type": "progene_text",
"text": [
"Insulin - stimulated recruitment of GLUT1 to plasma membranes of cells overexpressing PKCbetaII , - delta , and - epsilon , was greater than that in control cells ."
],
"offsets": [
[
0,
164
]
]
}
]
| [
{
"id": "split_0_train_1311_entity",
"type": "progene_text",
"text": [
"Insulin"
],
"offsets": [
[
0,
7
]
],
"normalized": []
},
{
"id": "split_0_train_1312_entity",
"type": "progene_text",
"text": [
"GLUT1"
],
"offsets": [
[
36,
41
]
],
"normalized": []
},
{
"id": "split_0_train_1313_entity",
"type": "progene_text",
"text": [
"PKCbetaII , - delta , and - epsilon"
],
"offsets": [
[
86,
121
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_970 | split_0_train_970 | [
{
"id": "split_0_train_970_passage",
"type": "progene_text",
"text": [
"The data suggest that more than one PKC isozyme is involved in insulin signaling pathways in fibroblasts , resulting in increased GLUT1 transporter recruitment to cell membranes ."
],
"offsets": [
[
0,
179
]
]
}
]
| [
{
"id": "split_0_train_1314_entity",
"type": "progene_text",
"text": [
"PKC"
],
"offsets": [
[
36,
39
]
],
"normalized": []
},
{
"id": "split_0_train_1315_entity",
"type": "progene_text",
"text": [
"insulin"
],
"offsets": [
[
63,
70
]
],
"normalized": []
},
{
"id": "split_0_train_1316_entity",
"type": "progene_text",
"text": [
"GLUT1"
],
"offsets": [
[
130,
135
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_971 | split_0_train_971 | [
{
"id": "split_0_train_971_passage",
"type": "progene_text",
"text": [
"Cloning , expression , and fatty acid regulation of the human delta-5 desaturase ."
],
"offsets": [
[
0,
82
]
]
}
]
| [
{
"id": "split_0_train_1317_entity",
"type": "progene_text",
"text": [
"delta-5 desaturase"
],
"offsets": [
[
62,
80
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_972 | split_0_train_972 | [
{
"id": "split_0_train_972_passage",
"type": "progene_text",
"text": [
"Arachidonic ( 20:4(n-6 ) ) , eicosapentaenoic ( 20 : 5(n-3 ) ) , and docosahexaenoic ( 22 : 6(n-3 ) ) acids are major components of brain and retina phospholipids , substrates for eicosanoid production , and regulators of nuclear transcription factors ."
],
"offsets": [
[
0,
253
]
]
}
]
| [
{
"id": "split_0_train_1318_entity",
"type": "progene_text",
"text": [
"transcription factors"
],
"offsets": [
[
230,
251
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_973 | split_0_train_973 | [
{
"id": "split_0_train_973_passage",
"type": "progene_text",
"text": [
"One of the two rate - limiting steps in the production of these polyenoic fatty acids is the desaturation of 20:3(n-6 ) and 20 : 4(n-3 ) by Delta-5 desaturase ."
],
"offsets": [
[
0,
160
]
]
}
]
| [
{
"id": "split_0_train_1319_entity",
"type": "progene_text",
"text": [
"Delta-5 desaturase"
],
"offsets": [
[
140,
158
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_974 | split_0_train_974 | [
{
"id": "split_0_train_974_passage",
"type": "progene_text",
"text": [
"This report describes the cloning and expression of the human Delta-5 desaturase , and it compares the structural characteristics and nutritional regulation of the Delta-5 and Delta-6 desaturases ."
],
"offsets": [
[
0,
197
]
]
}
]
| [
{
"id": "split_0_train_1320_entity",
"type": "progene_text",
"text": [
"Delta-5 desaturase"
],
"offsets": [
[
62,
80
]
],
"normalized": []
},
{
"id": "split_0_train_1321_entity",
"type": "progene_text",
"text": [
"Delta-5 and Delta-6 desaturases"
],
"offsets": [
[
164,
195
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_975 | split_0_train_975 | [
{
"id": "split_0_train_975_passage",
"type": "progene_text",
"text": [
"The open reading frame of the human Delta-5 desaturase encodes a 444 - amino acid peptide which is identical in size to the Delta-6 desaturase and which shares 61 % identity with the human Delta-6 desaturase ."
],
"offsets": [
[
0,
209
]
]
}
]
| [
{
"id": "split_0_train_1322_entity",
"type": "progene_text",
"text": [
"Delta-5 desaturase"
],
"offsets": [
[
36,
54
]
],
"normalized": []
},
{
"id": "split_0_train_1323_entity",
"type": "progene_text",
"text": [
"Delta-6 desaturase"
],
"offsets": [
[
124,
142
]
],
"normalized": []
},
{
"id": "split_0_train_1324_entity",
"type": "progene_text",
"text": [
"Delta-6 desaturase"
],
"offsets": [
[
189,
207
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_976 | split_0_train_976 | [
{
"id": "split_0_train_976_passage",
"type": "progene_text",
"text": [
"The Delta-5 desaturase contains two membrane - spanning domains , three histidine - rich regions , and a cytochrome b(5) domain that all align perfectly with the same domains located in the Delta - 6 desaturase ."
],
"offsets": [
[
0,
212
]
]
}
]
| [
{
"id": "split_0_train_1325_entity",
"type": "progene_text",
"text": [
"Delta-5 desaturase"
],
"offsets": [
[
4,
22
]
],
"normalized": []
},
{
"id": "split_0_train_1326_entity",
"type": "progene_text",
"text": [
"Delta - 6 desaturase"
],
"offsets": [
[
190,
210
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_977 | split_0_train_977 | [
{
"id": "split_0_train_977_passage",
"type": "progene_text",
"text": [
"Expression of the open reading frame in Chinese hamster ovary cells instilled the ability to convert 20 : 3(n-6 ) to 20 : 4(n-6 ) ."
],
"offsets": [
[
0,
131
]
]
}
]
| []
| []
| []
| []
|
split_0_train_978 | split_0_train_978 | [
{
"id": "split_0_train_978_passage",
"type": "progene_text",
"text": [
"Northern analysis revealed that many human tissues including skeletal muscle , lung , placenta , kidney , and pancreas expressed Delta-5 desaturase mRNA , but Delta - 5 desaturase was most abundant in the liver , brain , and heart ."
],
"offsets": [
[
0,
232
]
]
}
]
| [
{
"id": "split_0_train_1327_entity",
"type": "progene_text",
"text": [
"Delta-5 desaturase"
],
"offsets": [
[
129,
147
]
],
"normalized": []
},
{
"id": "split_0_train_1328_entity",
"type": "progene_text",
"text": [
"Delta - 5 desaturase"
],
"offsets": [
[
159,
179
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_979 | split_0_train_979 | [
{
"id": "split_0_train_979_passage",
"type": "progene_text",
"text": [
"However , in all tissues , the abundance of Delta-5 desaturase mRNA was much lower than that observed for the Delta - 6 desaturase ."
],
"offsets": [
[
0,
132
]
]
}
]
| [
{
"id": "split_0_train_1329_entity",
"type": "progene_text",
"text": [
"Delta-5 desaturase"
],
"offsets": [
[
44,
62
]
],
"normalized": []
},
{
"id": "split_0_train_1330_entity",
"type": "progene_text",
"text": [
"Delta - 6 desaturase"
],
"offsets": [
[
110,
130
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_980 | split_0_train_980 | [
{
"id": "split_0_train_980_passage",
"type": "progene_text",
"text": [
"When rats were fed a diet containing 10 % safflower oil or menhaden fish oil , the level of hepatic mRNA for Delta-5 and Delta-6 desaturase was only 25 % of that found in the liver of rats fed a fat - free diet or a diet containing triolein ."
],
"offsets": [
[
0,
242
]
]
}
]
| [
{
"id": "split_0_train_1331_entity",
"type": "progene_text",
"text": [
"Delta-5 and Delta-6 desaturase"
],
"offsets": [
[
109,
139
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_981 | split_0_train_981 | [
{
"id": "split_0_train_981_passage",
"type": "progene_text",
"text": [
"Finally , a BLAST and Genemap search of the human genome revealed that the Delta-5 and Delta-6 desaturase genes reside in reverse orientation on chromosome 11 and that they are separated by < 11,000 base pairs ."
],
"offsets": [
[
0,
211
]
]
}
]
| [
{
"id": "split_0_train_1332_entity",
"type": "progene_text",
"text": [
"Delta-5 and Delta-6 desaturase"
],
"offsets": [
[
75,
105
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_982 | split_0_train_982 | [
{
"id": "split_0_train_982_passage",
"type": "progene_text",
"text": [
"FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors ."
],
"offsets": [
[
0,
148
]
]
}
]
| [
{
"id": "split_0_train_1333_entity",
"type": "progene_text",
"text": [
"FRS2"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_1334_entity",
"type": "progene_text",
"text": [
"fibroblast growth factor and nerve growth factor receptors"
],
"offsets": [
[
88,
146
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_983 | split_0_train_983 | [
{
"id": "split_0_train_983_passage",
"type": "progene_text",
"text": [
"The docking protein FRS2 was implicated in the transmission of extracellular signals from the fibroblast growth factor ( FGF ) or nerve growth factor ( NGF ) receptors to the Ras / mitogen - activated protein kinase signaling cascade ."
],
"offsets": [
[
0,
235
]
]
}
]
| [
{
"id": "split_0_train_1335_entity",
"type": "progene_text",
"text": [
"FRS2"
],
"offsets": [
[
20,
24
]
],
"normalized": []
},
{
"id": "split_0_train_1336_entity",
"type": "progene_text",
"text": [
"fibroblast growth factor ( FGF ) or nerve growth factor ( NGF ) receptors"
],
"offsets": [
[
94,
167
]
],
"normalized": []
},
{
"id": "split_0_train_1337_entity",
"type": "progene_text",
"text": [
"Ras"
],
"offsets": [
[
175,
178
]
],
"normalized": []
},
{
"id": "split_0_train_1338_entity",
"type": "progene_text",
"text": [
"mitogen - activated protein kinase"
],
"offsets": [
[
181,
215
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_984 | split_0_train_984 | [
{
"id": "split_0_train_984_passage",
"type": "progene_text",
"text": [
"The two members of the FRS2 family , FRS2alpha and FRS2beta , are structurally very similar ."
],
"offsets": [
[
0,
93
]
]
}
]
| [
{
"id": "split_0_train_1339_entity",
"type": "progene_text",
"text": [
"FRS2 family"
],
"offsets": [
[
23,
34
]
],
"normalized": []
},
{
"id": "split_0_train_1340_entity",
"type": "progene_text",
"text": [
"FRS2alpha"
],
"offsets": [
[
37,
46
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],
"normalized": []
},
{
"id": "split_0_train_1341_entity",
"type": "progene_text",
"text": [
"FRS2beta"
],
"offsets": [
[
51,
59
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_985 | split_0_train_985 | [
{
"id": "split_0_train_985_passage",
"type": "progene_text",
"text": [
"Each is composed of an N - terminal myristylation signal , a phosphotyrosine - binding ( PTB ) domain , and a C-terminal tail containing multiple binding sites for the SH2 domains of the adapter protein Grb2 and the protein tyrosine phosphatase Shp2 ."
],
"offsets": [
[
0,
251
]
]
}
]
| [
{
"id": "split_0_train_1342_entity",
"type": "progene_text",
"text": [
"adapter protein"
],
"offsets": [
[
187,
202
]
],
"normalized": []
},
{
"id": "split_0_train_1343_entity",
"type": "progene_text",
"text": [
"Grb2"
],
"offsets": [
[
203,
207
]
],
"normalized": []
},
{
"id": "split_0_train_1344_entity",
"type": "progene_text",
"text": [
"protein tyrosine phosphatase"
],
"offsets": [
[
216,
244
]
],
"normalized": []
},
{
"id": "split_0_train_1345_entity",
"type": "progene_text",
"text": [
"Shp2"
],
"offsets": [
[
245,
249
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_986 | split_0_train_986 | [
{
"id": "split_0_train_986_passage",
"type": "progene_text",
"text": [
"Here we show that the PTB domains of both the alpha and beta isoforms of FRS2 bind directly to the FGF or NGF receptors ."
],
"offsets": [
[
0,
121
]
]
}
]
| [
{
"id": "split_0_train_1346_entity",
"type": "progene_text",
"text": [
"alpha and beta isoforms of FRS2"
],
"offsets": [
[
46,
77
]
],
"normalized": []
},
{
"id": "split_0_train_1347_entity",
"type": "progene_text",
"text": [
"FGF or NGF receptors"
],
"offsets": [
[
99,
119
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_987 | split_0_train_987 | [
{
"id": "split_0_train_987_passage",
"type": "progene_text",
"text": [
"The PTB domains of the FRS2 proteins bind to a highly conserved sequence in the juxtamembrane region of FGFR1 ."
],
"offsets": [
[
0,
111
]
]
}
]
| [
{
"id": "split_0_train_1348_entity",
"type": "progene_text",
"text": [
"FRS2"
],
"offsets": [
[
23,
27
]
],
"normalized": []
},
{
"id": "split_0_train_1349_entity",
"type": "progene_text",
"text": [
"FGFR1"
],
"offsets": [
[
104,
109
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_988 | split_0_train_988 | [
{
"id": "split_0_train_988_passage",
"type": "progene_text",
"text": [
"While FGFR1 interacts with FRS2 constitutively , independent of ligand stimulation and tyrosine phosphorylation , NGF receptor ( TrkA ) binding to FRS2 is strongly dependent on receptor activation ."
],
"offsets": [
[
0,
198
]
]
}
]
| [
{
"id": "split_0_train_1350_entity",
"type": "progene_text",
"text": [
"FGFR1"
],
"offsets": [
[
6,
11
]
],
"normalized": []
},
{
"id": "split_0_train_1351_entity",
"type": "progene_text",
"text": [
"FRS2"
],
"offsets": [
[
27,
31
]
],
"normalized": []
},
{
"id": "split_0_train_1352_entity",
"type": "progene_text",
"text": [
"NGF receptor"
],
"offsets": [
[
114,
126
]
],
"normalized": []
},
{
"id": "split_0_train_1353_entity",
"type": "progene_text",
"text": [
"TrkA"
],
"offsets": [
[
129,
133
]
],
"normalized": []
},
{
"id": "split_0_train_1354_entity",
"type": "progene_text",
"text": [
"FRS2"
],
"offsets": [
[
147,
151
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_989 | split_0_train_989 | [
{
"id": "split_0_train_989_passage",
"type": "progene_text",
"text": [
"Complex formation with TrkA is dependent on phosphorylation of Y490 , a canonical PTB domain binding site that also functions as a binding site for Shc ( NPXpY ) ."
],
"offsets": [
[
0,
163
]
]
}
]
| [
{
"id": "split_0_train_1355_entity",
"type": "progene_text",
"text": [
"TrkA"
],
"offsets": [
[
23,
27
]
],
"normalized": []
},
{
"id": "split_0_train_1356_entity",
"type": "progene_text",
"text": [
"Shc"
],
"offsets": [
[
148,
151
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_990 | split_0_train_990 | [
{
"id": "split_0_train_990_passage",
"type": "progene_text",
"text": [
"Using deletion and alanine scanning mutagenesis as well as peptide competition assays , we demonstrate that the PTB domains of the FRS2 proteins specifically recognize two different primary structures in two different receptors in a phosphorylation - dependent or - independent manner ."
],
"offsets": [
[
0,
286
]
]
}
]
| [
{
"id": "split_0_train_1357_entity",
"type": "progene_text",
"text": [
"FRS2"
],
"offsets": [
[
131,
135
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_991 | split_0_train_991 | [
{
"id": "split_0_train_991_passage",
"type": "progene_text",
"text": [
"In addition , NGF - induced tyrosine phosphorylation of FRS2alpha is diminished in cells that overexpress a kinase - inactive mutant of FGFR1 ."
],
"offsets": [
[
0,
143
]
]
}
]
| [
{
"id": "split_0_train_1358_entity",
"type": "progene_text",
"text": [
"NGF"
],
"offsets": [
[
14,
17
]
],
"normalized": []
},
{
"id": "split_0_train_1359_entity",
"type": "progene_text",
"text": [
"FRS2alpha"
],
"offsets": [
[
56,
65
]
],
"normalized": []
},
{
"id": "split_0_train_1360_entity",
"type": "progene_text",
"text": [
"kinase"
],
"offsets": [
[
108,
114
]
],
"normalized": []
},
{
"id": "split_0_train_1361_entity",
"type": "progene_text",
"text": [
"FGFR1"
],
"offsets": [
[
136,
141
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_992 | split_0_train_992 | [
{
"id": "split_0_train_992_passage",
"type": "progene_text",
"text": [
"This experiment suggests that FGFR1 may regulate signaling via NGF receptors by sequestering a common key element which both receptors utilize for transmitting their signals ."
],
"offsets": [
[
0,
175
]
]
}
]
| [
{
"id": "split_0_train_1362_entity",
"type": "progene_text",
"text": [
"FGFR1"
],
"offsets": [
[
30,
35
]
],
"normalized": []
},
{
"id": "split_0_train_1363_entity",
"type": "progene_text",
"text": [
"NGF receptors"
],
"offsets": [
[
63,
76
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_993 | split_0_train_993 | [
{
"id": "split_0_train_993_passage",
"type": "progene_text",
"text": [
"The multiple interactions mediated by FRS2 appear to play an important role in target selection and in defining the specificity of several families of receptor tyrosine kinases ."
],
"offsets": [
[
0,
178
]
]
}
]
| [
{
"id": "split_0_train_1364_entity",
"type": "progene_text",
"text": [
"FRS2"
],
"offsets": [
[
38,
42
]
],
"normalized": []
},
{
"id": "split_0_train_1365_entity",
"type": "progene_text",
"text": [
"receptor tyrosine kinases"
],
"offsets": [
[
151,
176
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_994 | split_0_train_994 | [
{
"id": "split_0_train_994_passage",
"type": "progene_text",
"text": [
"Cloning , expression , and functional characterization of the beta regulatory subunit of human methionine adenosyltransferase ( MAT II ) ."
],
"offsets": [
[
0,
138
]
]
}
]
| [
{
"id": "split_0_train_1366_entity",
"type": "progene_text",
"text": [
"beta regulatory subunit of human methionine adenosyltransferase"
],
"offsets": [
[
62,
125
]
],
"normalized": []
},
{
"id": "split_0_train_1367_entity",
"type": "progene_text",
"text": [
"MAT II"
],
"offsets": [
[
128,
134
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_995 | split_0_train_995 | [
{
"id": "split_0_train_995_passage",
"type": "progene_text",
"text": [
"MAT II , the extrahepatic form of methionine adenosyltransferase ( MAT ) , consists of catalytic alpha(2)/alpha(2') subunits and a noncatalytic beta subunit , believed to have a regulatory function ."
],
"offsets": [
[
0,
199
]
]
}
]
| [
{
"id": "split_0_train_1368_entity",
"type": "progene_text",
"text": [
"MAT II"
],
"offsets": [
[
0,
6
]
],
"normalized": []
},
{
"id": "split_0_train_1369_entity",
"type": "progene_text",
"text": [
"methionine adenosyltransferase"
],
"offsets": [
[
34,
64
]
],
"normalized": []
},
{
"id": "split_0_train_1370_entity",
"type": "progene_text",
"text": [
"MAT"
],
"offsets": [
[
67,
70
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_996 | split_0_train_996 | [
{
"id": "split_0_train_996_passage",
"type": "progene_text",
"text": [
"The full - length cDNA that encodes the beta subunit of human MAT II was cloned and found to encode for a 334 - amino acid protein with a calculated molecular weight of 37 , 552 ."
],
"offsets": [
[
0,
179
]
]
}
]
| [
{
"id": "split_0_train_1371_entity",
"type": "progene_text",
"text": [
"MAT II"
],
"offsets": [
[
62,
68
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_997 | split_0_train_997 | [
{
"id": "split_0_train_997_passage",
"type": "progene_text",
"text": [
"Analysis of sequence homology showed similarity with bacterial enzymes that catalyze the reduction of TDP - linked sugars ."
],
"offsets": [
[
0,
123
]
]
}
]
| []
| []
| []
| []
|
split_0_train_998 | split_0_train_998 | [
{
"id": "split_0_train_998_passage",
"type": "progene_text",
"text": [
"The beta subunit cDNA was cloned into the pQE-30 expression vector , and the recombinant His tagged protein , which was expressed in Escherichia coli , was recognized by antibodies to the human MAT II , to synthetic peptides copying the sequence of native beta subunit protein , and to the rbeta protein ."
],
"offsets": [
[
0,
305
]
]
}
]
| [
{
"id": "split_0_train_1372_entity",
"type": "progene_text",
"text": [
"MAT II"
],
"offsets": [
[
194,
200
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_999 | split_0_train_999 | [
{
"id": "split_0_train_999_passage",
"type": "progene_text",
"text": [
"There is no cross - reactivity between the MAT II alpha(2) or beta subunits ."
],
"offsets": [
[
0,
77
]
]
}
]
| [
{
"id": "split_0_train_1373_entity",
"type": "progene_text",
"text": [
"MAT II alpha(2) or beta"
],
"offsets": [
[
43,
66
]
],
"normalized": []
}
]
| []
| []
| []
|
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