id
stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
split_0_train_800 | split_0_train_800 | [
{
"id": "split_0_train_800_passage",
"type": "progene_text",
"text": [
"The gene katX , which encodes a catalase in Bacillus subtilis , is transcribed by EsigmaF in the pre - spore ."
],
"offsets": [
[
0,
110
]
]
}
]
| [
{
"id": "split_0_train_1065_entity",
"type": "progene_text",
"text": [
"katX"
],
"offsets": [
[
9,
13
]
],
"normalized": []
},
{
"id": "split_0_train_1066_entity",
"type": "progene_text",
"text": [
"catalase"
],
"offsets": [
[
32,
40
]
],
"normalized": []
},
{
"id": "split_0_train_1067_entity",
"type": "progene_text",
"text": [
"EsigmaF"
],
"offsets": [
[
82,
89
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_801 | split_0_train_801 | [
{
"id": "split_0_train_801_passage",
"type": "progene_text",
"text": [
"This catalase is responsible for the resistance to hydrogen peroxide shown by germinating and outgrowing spores ."
],
"offsets": [
[
0,
113
]
]
}
]
| [
{
"id": "split_0_train_1068_entity",
"type": "progene_text",
"text": [
"catalase"
],
"offsets": [
[
5,
13
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_802 | split_0_train_802 | [
{
"id": "split_0_train_802_passage",
"type": "progene_text",
"text": [
"We demonstrated that katX is also a sigmaB - dependent general stress gene , since it is strongly induced by heat , salt and ethanol stress , as well as by energy depletion ."
],
"offsets": [
[
0,
174
]
]
}
]
| [
{
"id": "split_0_train_1069_entity",
"type": "progene_text",
"text": [
"katX"
],
"offsets": [
[
21,
25
]
],
"normalized": []
},
{
"id": "split_0_train_1070_entity",
"type": "progene_text",
"text": [
"sigmaB"
],
"offsets": [
[
36,
42
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_803 | split_0_train_803 | [
{
"id": "split_0_train_803_passage",
"type": "progene_text",
"text": [
"The - 10 and - 35 sequences of the sigmaB - and sigmaF - dependent promoters of katX overlap , and the transcriptional start points used by EsigmaB and EsigmaF differ by only one nucleotide ."
],
"offsets": [
[
0,
191
]
]
}
]
| [
{
"id": "split_0_train_1071_entity",
"type": "progene_text",
"text": [
"sigmaB"
],
"offsets": [
[
35,
41
]
],
"normalized": []
},
{
"id": "split_0_train_1072_entity",
"type": "progene_text",
"text": [
"sigmaF"
],
"offsets": [
[
48,
54
]
],
"normalized": []
},
{
"id": "split_0_train_1073_entity",
"type": "progene_text",
"text": [
"katX"
],
"offsets": [
[
80,
84
]
],
"normalized": []
},
{
"id": "split_0_train_1074_entity",
"type": "progene_text",
"text": [
"EsigmaB"
],
"offsets": [
[
140,
147
]
],
"normalized": []
},
{
"id": "split_0_train_1075_entity",
"type": "progene_text",
"text": [
"EsigmaF"
],
"offsets": [
[
152,
159
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_804 | split_0_train_804 | [
{
"id": "split_0_train_804_passage",
"type": "progene_text",
"text": [
"Our results indicate that the level of KatX level in outgrowing spores depends mainly on EsigmaF , because sigB mutants show normal KatX activity in dormant and outgrowing spores ."
],
"offsets": [
[
0,
180
]
]
}
]
| [
{
"id": "split_0_train_1076_entity",
"type": "progene_text",
"text": [
"KatX"
],
"offsets": [
[
39,
43
]
],
"normalized": []
},
{
"id": "split_0_train_1077_entity",
"type": "progene_text",
"text": [
"EsigmaF"
],
"offsets": [
[
89,
96
]
],
"normalized": []
},
{
"id": "split_0_train_1078_entity",
"type": "progene_text",
"text": [
"sigB"
],
"offsets": [
[
107,
111
]
],
"normalized": []
},
{
"id": "split_0_train_1079_entity",
"type": "progene_text",
"text": [
"KatX"
],
"offsets": [
[
132,
136
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_805 | split_0_train_805 | [
{
"id": "split_0_train_805_passage",
"type": "progene_text",
"text": [
"katX mutants also develop the non - specific resistance to oxidative stress that is typical of glucose - starved cells ."
],
"offsets": [
[
0,
120
]
]
}
]
| [
{
"id": "split_0_train_1080_entity",
"type": "progene_text",
"text": [
"katX"
],
"offsets": [
[
0,
4
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_806 | split_0_train_806 | [
{
"id": "split_0_train_806_passage",
"type": "progene_text",
"text": [
"Therefore , the physiological role of sigmaB - dependent katX expression remains obscure ."
],
"offsets": [
[
0,
90
]
]
}
]
| [
{
"id": "split_0_train_1081_entity",
"type": "progene_text",
"text": [
"sigmaB"
],
"offsets": [
[
38,
44
]
],
"normalized": []
},
{
"id": "split_0_train_1082_entity",
"type": "progene_text",
"text": [
"katX"
],
"offsets": [
[
57,
61
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_807 | split_0_train_807 | [
{
"id": "split_0_train_807_passage",
"type": "progene_text",
"text": [
"The results indicate an overlap between the sigmaB regulon and the sigmaF regulon , and the physiological implications of this overlap are discussed ."
],
"offsets": [
[
0,
150
]
]
}
]
| [
{
"id": "split_0_train_1083_entity",
"type": "progene_text",
"text": [
"sigmaB"
],
"offsets": [
[
44,
50
]
],
"normalized": []
},
{
"id": "split_0_train_1084_entity",
"type": "progene_text",
"text": [
"sigmaF"
],
"offsets": [
[
67,
73
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_808 | split_0_train_808 | [
{
"id": "split_0_train_808_passage",
"type": "progene_text",
"text": [
"Presenilin 1 suppresses the function of c-Jun homodimers via interaction with QM / Jif-1 ."
],
"offsets": [
[
0,
90
]
]
}
]
| [
{
"id": "split_0_train_1085_entity",
"type": "progene_text",
"text": [
"Presenilin 1"
],
"offsets": [
[
0,
12
]
],
"normalized": []
},
{
"id": "split_0_train_1086_entity",
"type": "progene_text",
"text": [
"c-Jun"
],
"offsets": [
[
40,
45
]
],
"normalized": []
},
{
"id": "split_0_train_1087_entity",
"type": "progene_text",
"text": [
"QM"
],
"offsets": [
[
78,
80
]
],
"normalized": []
},
{
"id": "split_0_train_1088_entity",
"type": "progene_text",
"text": [
"Jif-1"
],
"offsets": [
[
83,
88
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_809 | split_0_train_809 | [
{
"id": "split_0_train_809_passage",
"type": "progene_text",
"text": [
"Presenilin 1 ( PS1 ) is the causative gene for an autosomal dominant familial Alzheimer 's disease ( AD ) mapped to chromosome 14 ."
],
"offsets": [
[
0,
131
]
]
}
]
| [
{
"id": "split_0_train_1089_entity",
"type": "progene_text",
"text": [
"Presenilin 1"
],
"offsets": [
[
0,
12
]
],
"normalized": []
},
{
"id": "split_0_train_1090_entity",
"type": "progene_text",
"text": [
"PS1"
],
"offsets": [
[
15,
18
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_810 | split_0_train_810 | [
{
"id": "split_0_train_810_passage",
"type": "progene_text",
"text": [
"Here we show that QM / Jun - interacting factor ( Jif ) - 1 , a negative regulator of c-Jun , is a candidate to mediate the function of PS1 in the cell ."
],
"offsets": [
[
0,
153
]
]
}
]
| [
{
"id": "split_0_train_1091_entity",
"type": "progene_text",
"text": [
"QM"
],
"offsets": [
[
18,
20
]
],
"normalized": []
},
{
"id": "split_0_train_1092_entity",
"type": "progene_text",
"text": [
"Jun - interacting factor ( Jif ) - 1"
],
"offsets": [
[
23,
59
]
],
"normalized": []
},
{
"id": "split_0_train_1093_entity",
"type": "progene_text",
"text": [
"c-Jun"
],
"offsets": [
[
86,
91
]
],
"normalized": []
},
{
"id": "split_0_train_1094_entity",
"type": "progene_text",
"text": [
"PS1"
],
"offsets": [
[
136,
139
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_811 | split_0_train_811 | [
{
"id": "split_0_train_811_passage",
"type": "progene_text",
"text": [
"We screened for proteins that bind to PS1 from a human embryonic brain cDNA library using the two - hybrid method and isolated one clone encoding the QM / Jif-1 gene ."
],
"offsets": [
[
0,
167
]
]
}
]
| [
{
"id": "split_0_train_1095_entity",
"type": "progene_text",
"text": [
"PS1"
],
"offsets": [
[
38,
41
]
],
"normalized": []
},
{
"id": "split_0_train_1096_entity",
"type": "progene_text",
"text": [
"QM"
],
"offsets": [
[
150,
152
]
],
"normalized": []
},
{
"id": "split_0_train_1097_entity",
"type": "progene_text",
"text": [
"Jif-1"
],
"offsets": [
[
155,
160
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_812 | split_0_train_812 | [
{
"id": "split_0_train_812_passage",
"type": "progene_text",
"text": [
"The binding of QM / Jif-1 to full - length PS1 was confirmed in vitro by pull - down assay , and in vivo by immunoprecipitation assays with human samples , including AD brains ."
],
"offsets": [
[
0,
177
]
]
}
]
| [
{
"id": "split_0_train_1098_entity",
"type": "progene_text",
"text": [
"QM"
],
"offsets": [
[
15,
17
]
],
"normalized": []
},
{
"id": "split_0_train_1099_entity",
"type": "progene_text",
"text": [
"Jif-1"
],
"offsets": [
[
20,
25
]
],
"normalized": []
},
{
"id": "split_0_train_1100_entity",
"type": "progene_text",
"text": [
"PS1"
],
"offsets": [
[
43,
46
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_813 | split_0_train_813 | [
{
"id": "split_0_train_813_passage",
"type": "progene_text",
"text": [
"Immunoelectronmicroscopic analysis showed that QM / Jif-1 and PS1 are colocalized at the endoplasmic reticulum , and the nuclear matrix in human brain neurons ."
],
"offsets": [
[
0,
160
]
]
}
]
| [
{
"id": "split_0_train_1101_entity",
"type": "progene_text",
"text": [
"QM"
],
"offsets": [
[
47,
49
]
],
"normalized": []
},
{
"id": "split_0_train_1102_entity",
"type": "progene_text",
"text": [
"Jif-1"
],
"offsets": [
[
52,
57
]
],
"normalized": []
},
{
"id": "split_0_train_1103_entity",
"type": "progene_text",
"text": [
"PS1"
],
"offsets": [
[
62,
65
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_814 | split_0_train_814 | [
{
"id": "split_0_train_814_passage",
"type": "progene_text",
"text": [
"Chloramphenicol acetyltransferase assays in F9 cells showed that PS1 suppresses transactivation by c-Jun / c-Jun but not by c-Jun / c-Fos heterodimers , consistent with the reported function of QM / Jif-1 ."
],
"offsets": [
[
0,
206
]
]
}
]
| [
{
"id": "split_0_train_1104_entity",
"type": "progene_text",
"text": [
"Chloramphenicol acetyltransferase"
],
"offsets": [
[
0,
33
]
],
"normalized": []
},
{
"id": "split_0_train_1105_entity",
"type": "progene_text",
"text": [
"PS1"
],
"offsets": [
[
65,
68
]
],
"normalized": []
},
{
"id": "split_0_train_1106_entity",
"type": "progene_text",
"text": [
"c-Jun"
],
"offsets": [
[
99,
104
]
],
"normalized": []
},
{
"id": "split_0_train_1107_entity",
"type": "progene_text",
"text": [
"c-Jun"
],
"offsets": [
[
107,
112
]
],
"normalized": []
},
{
"id": "split_0_train_1108_entity",
"type": "progene_text",
"text": [
"c-Jun"
],
"offsets": [
[
124,
129
]
],
"normalized": []
},
{
"id": "split_0_train_1109_entity",
"type": "progene_text",
"text": [
"c-Fos"
],
"offsets": [
[
132,
137
]
],
"normalized": []
},
{
"id": "split_0_train_1110_entity",
"type": "progene_text",
"text": [
"QM"
],
"offsets": [
[
194,
196
]
],
"normalized": []
},
{
"id": "split_0_train_1111_entity",
"type": "progene_text",
"text": [
"Jif-1"
],
"offsets": [
[
199,
204
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_815 | split_0_train_815 | [
{
"id": "split_0_train_815_passage",
"type": "progene_text",
"text": [
"By monitoring fluorescent recombinant protein and by gel mobility shift assays , PS1 was shown to accelerate the translocation of QM from the cytoplasm to the nucleus and to thereby suppress the binding of c-Jun homodimer to 12-O-tetradecanoylphorbol-13 - acetate ( TPA ) - responsive element ( TRE ) ."
],
"offsets": [
[
0,
302
]
]
}
]
| [
{
"id": "split_0_train_1112_entity",
"type": "progene_text",
"text": [
"PS1"
],
"offsets": [
[
81,
84
]
],
"normalized": []
},
{
"id": "split_0_train_1113_entity",
"type": "progene_text",
"text": [
"QM"
],
"offsets": [
[
130,
132
]
],
"normalized": []
},
{
"id": "split_0_train_1114_entity",
"type": "progene_text",
"text": [
"c-Jun"
],
"offsets": [
[
206,
211
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_816 | split_0_train_816 | [
{
"id": "split_0_train_816_passage",
"type": "progene_text",
"text": [
"PS1 suppressed c-jun - associated apoptosis by retinoic acid in F9 embryonic carcinoma cells , whereas this suppression of apoptosis is attenuated by mutation in PS1 ."
],
"offsets": [
[
0,
167
]
]
}
]
| [
{
"id": "split_0_train_1115_entity",
"type": "progene_text",
"text": [
"PS1"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "split_0_train_1116_entity",
"type": "progene_text",
"text": [
"c-jun"
],
"offsets": [
[
15,
20
]
],
"normalized": []
},
{
"id": "split_0_train_1117_entity",
"type": "progene_text",
"text": [
"PS1"
],
"offsets": [
[
162,
165
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_817 | split_0_train_817 | [
{
"id": "split_0_train_817_passage",
"type": "progene_text",
"text": [
"Collectively , the novel function of PS1 via QM / Jif-1 influences c-jun - mediated transcription and apoptosis ."
],
"offsets": [
[
0,
113
]
]
}
]
| [
{
"id": "split_0_train_1118_entity",
"type": "progene_text",
"text": [
"PS1"
],
"offsets": [
[
37,
40
]
],
"normalized": []
},
{
"id": "split_0_train_1119_entity",
"type": "progene_text",
"text": [
"QM"
],
"offsets": [
[
45,
47
]
],
"normalized": []
},
{
"id": "split_0_train_1120_entity",
"type": "progene_text",
"text": [
"Jif-1"
],
"offsets": [
[
50,
55
]
],
"normalized": []
},
{
"id": "split_0_train_1121_entity",
"type": "progene_text",
"text": [
"c-jun"
],
"offsets": [
[
67,
72
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_818 | split_0_train_818 | [
{
"id": "split_0_train_818_passage",
"type": "progene_text",
"text": [
"A comparative study of nerve healing in adult , neonatal , and fetal rabbits ."
],
"offsets": [
[
0,
78
]
]
}
]
| []
| []
| []
| []
|
split_0_train_819 | split_0_train_819 | [
{
"id": "split_0_train_819_passage",
"type": "progene_text",
"text": [
"This experiment quantitatively compared the human equivalent of a nerve repair following surgical division in the fetal , adult , and early childhood period of development using a rabbit as an experimental animal model ."
],
"offsets": [
[
0,
220
]
]
}
]
| []
| []
| []
| []
|
split_0_train_820 | split_0_train_820 | [
{
"id": "split_0_train_820_passage",
"type": "progene_text",
"text": [
"Twelve time - dated pregnant New Zealand White rabbits at 24 days ' gestation ( term = 31 days ) underwent hysterotomy ; one hind limb was delivered through the uterine opening ."
],
"offsets": [
[
0,
178
]
]
}
]
| []
| []
| []
| []
|
split_0_train_821 | split_0_train_821 | [
{
"id": "split_0_train_821_passage",
"type": "progene_text",
"text": [
"The sciatic nerve was divided and repaired by primary neurorrhaphy using two 11 - 0 epineural sutures ."
],
"offsets": [
[
0,
103
]
]
}
]
| []
| []
| []
| []
|
split_0_train_822 | split_0_train_822 | [
{
"id": "split_0_train_822_passage",
"type": "progene_text",
"text": [
"Sciatic nerve repair was also performed in 10 neonatal and 10 adult New Zealand White rabbits ."
],
"offsets": [
[
0,
95
]
]
}
]
| []
| []
| []
| []
|
split_0_train_823 | split_0_train_823 | [
{
"id": "split_0_train_823_passage",
"type": "progene_text",
"text": [
"Following repair , each group was assessed using electromyography examination , measuring distal motor latency and amplitude at 1 , 2 , 3 , and 4 months postrepair ."
],
"offsets": [
[
0,
165
]
]
}
]
| []
| []
| []
| []
|
split_0_train_824 | split_0_train_824 | [
{
"id": "split_0_train_824_passage",
"type": "progene_text",
"text": [
"There was no difference in any of the groups in distal motor latency ."
],
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[
0,
70
]
]
}
]
| []
| []
| []
| []
|
split_0_train_825 | split_0_train_825 | [
{
"id": "split_0_train_825_passage",
"type": "progene_text",
"text": [
"The amplitude rose incrementally in all groups , and the fetal group had significantly higher amplitudes ( p < 0.02 ) at 1 , 2 , 3 , and 4 months in comparison with the adult group ."
],
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[
0,
182
]
]
}
]
| []
| []
| []
| []
|
split_0_train_826 | split_0_train_826 | [
{
"id": "split_0_train_826_passage",
"type": "progene_text",
"text": [
"There was no statistically significant difference between fetal and neonatal nerve repairs at any of the time periods ."
],
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[
0,
119
]
]
}
]
| []
| []
| []
| []
|
split_0_train_827 | split_0_train_827 | [
{
"id": "split_0_train_827_passage",
"type": "progene_text",
"text": [
"At the completion of the study , the nerve repair sites were harvested for histologic estimation of mean myelinated fiber density and fiber diameter distribution distal and proximal to the repair site ."
],
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[
0,
202
]
]
}
]
| []
| []
| []
| []
|
split_0_train_828 | split_0_train_828 | [
{
"id": "split_0_train_828_passage",
"type": "progene_text",
"text": [
"A greater percentage of myelinated axons crossed the repair site in the fetal group ( 83 percent ) in comparison with the adult group ( 63 percent ) ( p < 0.03 ) ."
],
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[
0,
163
]
]
}
]
| []
| []
| []
| []
|
split_0_train_829 | split_0_train_829 | [
{
"id": "split_0_train_829_passage",
"type": "progene_text",
"text": [
"Our study also demonstrated significant increases in the number of larger myelinated fibers crossing the repair site in comparison with the neonatal and adult groups ( p < 0.04 ) ."
],
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[
0,
180
]
]
}
]
| []
| []
| []
| []
|
split_0_train_830 | split_0_train_830 | [
{
"id": "split_0_train_830_passage",
"type": "progene_text",
"text": [
"This study found that fetal nerve healing following surgical repair is superior to that found in adult animals and results in a higher number of larger myelinated fibers crossing the repair site in comparison with adult and neonatal repairs ."
],
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[
0,
242
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]
}
]
| []
| []
| []
| []
|
split_0_train_831 | split_0_train_831 | [
{
"id": "split_0_train_831_passage",
"type": "progene_text",
"text": [
"Slope water current over the laurentian fan on interannual to millennial time scales The strength and position of surface and deep currents in the slope water south of Newfoundland are thought to vary as a coupled system in relation to the dipole in atmospheric sea level pressure known as the North Atlantic oscillation ( NAO ) ."
],
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0,
330
]
]
}
]
| []
| []
| []
| []
|
split_0_train_832 | split_0_train_832 | [
{
"id": "split_0_train_832_passage",
"type": "progene_text",
"text": [
"Paleoceanographic data from the Laurentian Fan , used as a proxy for sea surface temperature , reveal that surface slope waters north of the Gulf Stream experienced warming during the Little Ice Age of the 16th to 19th centuries and support the notion of an NAO - driven coupled system ."
],
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0,
287
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]
}
]
| []
| []
| []
| []
|
split_0_train_833 | split_0_train_833 | [
{
"id": "split_0_train_833_passage",
"type": "progene_text",
"text": [
"The NAO may be a useful model for millennial - scale ocean variability during interglacial climate states ."
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0,
107
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}
]
| []
| []
| []
| []
|
split_0_train_834 | split_0_train_834 | [
{
"id": "split_0_train_834_passage",
"type": "progene_text",
"text": [
"Requirement for Ras / Rac1 - mediated p38 and c-Jun N - terminal kinase signaling in Stat3 transcriptional activity induced by the Src oncoprotein ."
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0,
148
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16,
19
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22,
26
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{
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38,
41
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{
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46,
71
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{
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"text": [
"Stat3"
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85,
90
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{
"id": "split_0_train_1127_entity",
"type": "progene_text",
"text": [
"Src"
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[
131,
134
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}
]
| []
| []
| []
|
split_0_train_835 | split_0_train_835 | [
{
"id": "split_0_train_835_passage",
"type": "progene_text",
"text": [
"Signal transducers and activators of transcription ( STATs ) are transcription factors that mediate normal biologic responses to cytokines and growth factors ."
],
"offsets": [
[
0,
159
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]
}
]
| [
{
"id": "split_0_train_1128_entity",
"type": "progene_text",
"text": [
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{
"id": "split_0_train_1129_entity",
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53,
58
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{
"id": "split_0_train_1130_entity",
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"text": [
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65,
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{
"id": "split_0_train_1131_entity",
"type": "progene_text",
"text": [
"cytokines"
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129,
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{
"id": "split_0_train_1132_entity",
"type": "progene_text",
"text": [
"growth factors"
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143,
157
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}
]
| []
| []
| []
|
split_0_train_836 | split_0_train_836 | [
{
"id": "split_0_train_836_passage",
"type": "progene_text",
"text": [
"However , abnormal activation of certain STAT family members , including Stat3 , is increasingly associated with oncogenesis ."
],
"offsets": [
[
0,
126
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}
]
| [
{
"id": "split_0_train_1133_entity",
"type": "progene_text",
"text": [
"STAT family"
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41,
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{
"id": "split_0_train_1134_entity",
"type": "progene_text",
"text": [
"Stat3"
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[
73,
78
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_837 | split_0_train_837 | [
{
"id": "split_0_train_837_passage",
"type": "progene_text",
"text": [
"In fibroblasts expressing the Src oncoprotein , activation of Stat3 induces specific gene expression and is required for cell transformation ."
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"offsets": [
[
0,
142
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}
]
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{
"id": "split_0_train_1135_entity",
"type": "progene_text",
"text": [
"Src"
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30,
33
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{
"id": "split_0_train_1136_entity",
"type": "progene_text",
"text": [
"Stat3"
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[
62,
67
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_838 | split_0_train_838 | [
{
"id": "split_0_train_838_passage",
"type": "progene_text",
"text": [
"Although the Src tyrosine kinase induces constitutive Stat3 phosphorylation on tyrosine , activation of Stat3 - mediated gene regulation requires both tyrosine and serine phosphorylation of Stat3 ."
],
"offsets": [
[
0,
197
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]
}
]
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{
"id": "split_0_train_1137_entity",
"type": "progene_text",
"text": [
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13,
16
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{
"id": "split_0_train_1138_entity",
"type": "progene_text",
"text": [
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17,
32
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{
"id": "split_0_train_1139_entity",
"type": "progene_text",
"text": [
"Stat3"
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54,
59
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{
"id": "split_0_train_1140_entity",
"type": "progene_text",
"text": [
"Stat3"
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104,
109
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{
"id": "split_0_train_1141_entity",
"type": "progene_text",
"text": [
"Stat3"
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[
190,
195
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"normalized": []
}
]
| []
| []
| []
|
split_0_train_839 | split_0_train_839 | [
{
"id": "split_0_train_839_passage",
"type": "progene_text",
"text": [
"We investigated the signaling pathways underlying the constitutive Stat3 activation in Src oncogenesis ."
],
"offsets": [
[
0,
104
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]
}
]
| [
{
"id": "split_0_train_1142_entity",
"type": "progene_text",
"text": [
"Stat3"
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67,
72
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{
"id": "split_0_train_1143_entity",
"type": "progene_text",
"text": [
"Src"
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"offsets": [
[
87,
90
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_840 | split_0_train_840 | [
{
"id": "split_0_train_840_passage",
"type": "progene_text",
"text": [
"Expression of Ras or Rac1 dominant negative protein blocks Stat3 - mediated gene regulation induced by Src in a manner consistent with dependence on p38 and c-Jun N - terminal kinase ( JNK ) ."
],
"offsets": [
[
0,
192
]
]
}
]
| [
{
"id": "split_0_train_1144_entity",
"type": "progene_text",
"text": [
"Ras"
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"offsets": [
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14,
17
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},
{
"id": "split_0_train_1145_entity",
"type": "progene_text",
"text": [
"Rac1"
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"offsets": [
[
21,
25
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"normalized": []
},
{
"id": "split_0_train_1146_entity",
"type": "progene_text",
"text": [
"Stat3"
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"offsets": [
[
59,
64
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"normalized": []
},
{
"id": "split_0_train_1147_entity",
"type": "progene_text",
"text": [
"Src"
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103,
106
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{
"id": "split_0_train_1148_entity",
"type": "progene_text",
"text": [
"p38"
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149,
152
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"normalized": []
},
{
"id": "split_0_train_1149_entity",
"type": "progene_text",
"text": [
"c-Jun N - terminal kinase"
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[
157,
182
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"normalized": []
},
{
"id": "split_0_train_1150_entity",
"type": "progene_text",
"text": [
"JNK"
],
"offsets": [
[
185,
188
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_841 | split_0_train_841 | [
{
"id": "split_0_train_841_passage",
"type": "progene_text",
"text": [
"Both of these serine / threonine kinases and Stat3 serine phosphorylation are constitutively induced in Src - transformed fibroblasts ."
],
"offsets": [
[
0,
135
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]
}
]
| [
{
"id": "split_0_train_1151_entity",
"type": "progene_text",
"text": [
"serine / threonine kinases"
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"offsets": [
[
14,
40
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{
"id": "split_0_train_1152_entity",
"type": "progene_text",
"text": [
"Stat3"
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"offsets": [
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45,
50
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],
"normalized": []
},
{
"id": "split_0_train_1153_entity",
"type": "progene_text",
"text": [
"Src"
],
"offsets": [
[
104,
107
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_842 | split_0_train_842 | [
{
"id": "split_0_train_842_passage",
"type": "progene_text",
"text": [
"Furthermore , inhibition of p38 and JNK activities suppresses constitutive Stat3 serine phosphorylation and Stat3 - mediated gene regulation ."
],
"offsets": [
[
0,
142
]
]
}
]
| [
{
"id": "split_0_train_1154_entity",
"type": "progene_text",
"text": [
"p38"
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"offsets": [
[
28,
31
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"normalized": []
},
{
"id": "split_0_train_1155_entity",
"type": "progene_text",
"text": [
"JNK"
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"offsets": [
[
36,
39
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"normalized": []
},
{
"id": "split_0_train_1156_entity",
"type": "progene_text",
"text": [
"Stat3"
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"offsets": [
[
75,
80
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"normalized": []
},
{
"id": "split_0_train_1157_entity",
"type": "progene_text",
"text": [
"Stat3"
],
"offsets": [
[
108,
113
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_843 | split_0_train_843 | [
{
"id": "split_0_train_843_passage",
"type": "progene_text",
"text": [
"In vitro kinase assays with purified full - length Stat3 as the substrate show that both JNK and p38 can phosphorylate Stat3 on serine ."
],
"offsets": [
[
0,
136
]
]
}
]
| [
{
"id": "split_0_train_1158_entity",
"type": "progene_text",
"text": [
"kinase"
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"offsets": [
[
9,
15
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{
"id": "split_0_train_1159_entity",
"type": "progene_text",
"text": [
"Stat3"
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51,
56
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"normalized": []
},
{
"id": "split_0_train_1160_entity",
"type": "progene_text",
"text": [
"JNK"
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"offsets": [
[
89,
92
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],
"normalized": []
},
{
"id": "split_0_train_1161_entity",
"type": "progene_text",
"text": [
"p38"
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97,
100
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},
{
"id": "split_0_train_1162_entity",
"type": "progene_text",
"text": [
"Stat3"
],
"offsets": [
[
119,
124
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_844 | split_0_train_844 | [
{
"id": "split_0_train_844_passage",
"type": "progene_text",
"text": [
"Moreover , inhibition of p38 activity and thus of Stat3 serine phosphorylation results in suppression of transformation by v-Src but not v-Ras , consistent with a requirement for Stat3 serine phosphorylation in Src transformation ."
],
"offsets": [
[
0,
231
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]
}
]
| [
{
"id": "split_0_train_1163_entity",
"type": "progene_text",
"text": [
"p38"
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25,
28
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},
{
"id": "split_0_train_1164_entity",
"type": "progene_text",
"text": [
"Stat3"
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[
50,
55
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},
{
"id": "split_0_train_1165_entity",
"type": "progene_text",
"text": [
"v-Src"
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[
123,
128
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],
"normalized": []
},
{
"id": "split_0_train_1166_entity",
"type": "progene_text",
"text": [
"v-Ras"
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[
137,
142
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},
{
"id": "split_0_train_1167_entity",
"type": "progene_text",
"text": [
"Stat3"
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179,
184
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},
{
"id": "split_0_train_1168_entity",
"type": "progene_text",
"text": [
"Src"
],
"offsets": [
[
211,
214
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_845 | split_0_train_845 | [
{
"id": "split_0_train_845_passage",
"type": "progene_text",
"text": [
"Our results demonstrate that Ras - and Rac1 - mediated p38 and JNK signals are required for Stat3 transcriptional activity induced by the Src oncoprotein ."
],
"offsets": [
[
0,
155
]
]
}
]
| [
{
"id": "split_0_train_1169_entity",
"type": "progene_text",
"text": [
"Ras"
],
"offsets": [
[
29,
32
]
],
"normalized": []
},
{
"id": "split_0_train_1170_entity",
"type": "progene_text",
"text": [
"Rac1"
],
"offsets": [
[
39,
43
]
],
"normalized": []
},
{
"id": "split_0_train_1171_entity",
"type": "progene_text",
"text": [
"p38"
],
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[
55,
58
]
],
"normalized": []
},
{
"id": "split_0_train_1172_entity",
"type": "progene_text",
"text": [
"JNK"
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[
63,
66
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],
"normalized": []
},
{
"id": "split_0_train_1173_entity",
"type": "progene_text",
"text": [
"Stat3"
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[
92,
97
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"normalized": []
},
{
"id": "split_0_train_1174_entity",
"type": "progene_text",
"text": [
"Src"
],
"offsets": [
[
138,
141
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_846 | split_0_train_846 | [
{
"id": "split_0_train_846_passage",
"type": "progene_text",
"text": [
"These findings delineate a network of tyrosine and serine / threonine kinase signaling pathways that converge on Stat3 in the context of oncogenesis ."
],
"offsets": [
[
0,
150
]
]
}
]
| [
{
"id": "split_0_train_1175_entity",
"type": "progene_text",
"text": [
"tyrosine and serine / threonine kinase"
],
"offsets": [
[
38,
76
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],
"normalized": []
},
{
"id": "split_0_train_1176_entity",
"type": "progene_text",
"text": [
"Stat3"
],
"offsets": [
[
113,
118
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_847 | split_0_train_847 | [
{
"id": "split_0_train_847_passage",
"type": "progene_text",
"text": [
"Smooth pursuit tracking deficits of patients with schizophrenia at specific within - sine wave bins ."
],
"offsets": [
[
0,
101
]
]
}
]
| []
| []
| []
| []
|
split_0_train_848 | split_0_train_848 | [
{
"id": "split_0_train_848_passage",
"type": "progene_text",
"text": [
"BACKGROUND :"
],
"offsets": [
[
0,
12
]
]
}
]
| []
| []
| []
| []
|
split_0_train_849 | split_0_train_849 | [
{
"id": "split_0_train_849_passage",
"type": "progene_text",
"text": [
"Early information processing deficits are consistently reported for patients with schizophrenia on smooth pursuit tracking tasks ."
],
"offsets": [
[
0,
130
]
]
}
]
| []
| []
| []
| []
|
split_0_train_850 | split_0_train_850 | [
{
"id": "split_0_train_850_passage",
"type": "progene_text",
"text": [
"A growing number of studies have applied a transient ( magnocellular ) or sustained ( parvocellular ) explanation to account for deficient processing of briefly presented visual stimuli , moving stimuli , and particularly , stimuli requiring smooth tracking eye movements in patients with schizophrenia ."
],
"offsets": [
[
0,
304
]
]
}
]
| []
| []
| []
| []
|
split_0_train_851 | split_0_train_851 | [
{
"id": "split_0_train_851_passage",
"type": "progene_text",
"text": [
"OBJECTIVE :"
],
"offsets": [
[
0,
11
]
]
}
]
| []
| []
| []
| []
|
split_0_train_852 | split_0_train_852 | [
{
"id": "split_0_train_852_passage",
"type": "progene_text",
"text": [
"Although the preponderance of findings offer support for transient ( where is it ? ) as opposed to sustained ( what is it ? ) deficit , a need remains for specific depiction of the deficit ."
],
"offsets": [
[
0,
190
]
]
}
]
| []
| []
| []
| []
|
split_0_train_853 | split_0_train_853 | [
{
"id": "split_0_train_853_passage",
"type": "progene_text",
"text": [
"This was accomplished by applying a unique analytic method to a smooth pursuit tracking task ."
],
"offsets": [
[
0,
94
]
]
}
]
| []
| []
| []
| []
|
split_0_train_854 | split_0_train_854 | [
{
"id": "split_0_train_854_passage",
"type": "progene_text",
"text": [
"METHODS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_855 | split_0_train_855 | [
{
"id": "split_0_train_855_passage",
"type": "progene_text",
"text": [
"Fourteen patients with schizophrenia and fifteen normal control subjects were tested on smooth pursuit tracking performance at five different \" within - wave \" dot velocity frequencies that ranged from .3 to 1.1 hz ."
],
"offsets": [
[
0,
216
]
]
}
]
| []
| []
| []
| []
|
split_0_train_856 | split_0_train_856 | [
{
"id": "split_0_train_856_passage",
"type": "progene_text",
"text": [
"Performance data was extracted from each of the five frequencies and then separated into 12 discrete components that corresponded to light velocity ( i.e. , 12 bins ) ."
],
"offsets": [
[
0,
168
]
]
}
]
| []
| []
| []
| []
|
split_0_train_857 | split_0_train_857 | [
{
"id": "split_0_train_857_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_858 | split_0_train_858 | [
{
"id": "split_0_train_858_passage",
"type": "progene_text",
"text": [
"A repeated measures multivariate analysis of covariance indicated that the performance of patients with schizophrenia was significantly poorer than that of their normal counterparts for three separate analyses of the time in smooth pursuit , F(11,594 ) = 8.99 ; p < 0.00001 , percentage of time in smooth pursuit , F(11,594 ) = 3.06 ; p < 0.0005 , and time in saccade eye movement , F(11,594 ) = 3.11 ; p < 0.0004 ."
],
"offsets": [
[
0,
415
]
]
}
]
| []
| []
| []
| []
|
split_0_train_859 | split_0_train_859 | [
{
"id": "split_0_train_859_passage",
"type": "progene_text",
"text": [
"A regression analysis revealed that the medication dosage was not significantly associated with performance on any of the critical measures , although trends were observed ."
],
"offsets": [
[
0,
173
]
]
}
]
| []
| []
| []
| []
|
split_0_train_860 | split_0_train_860 | [
{
"id": "split_0_train_860_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
]
| []
| []
| []
| []
|
split_0_train_861 | split_0_train_861 | [
{
"id": "split_0_train_861_passage",
"type": "progene_text",
"text": [
"The findings provide support for an early information processing deficit in patients with schizophrenia ."
],
"offsets": [
[
0,
105
]
]
}
]
| []
| []
| []
| []
|
split_0_train_862 | split_0_train_862 | [
{
"id": "split_0_train_862_passage",
"type": "progene_text",
"text": [
"In addition , the results support the current neurophysiologic model for abnormal smooth pursuit tracking in patients with schizophrenia , specifically implicating a transient channel deficiency ."
],
"offsets": [
[
0,
196
]
]
}
]
| []
| []
| []
| []
|
split_0_train_863 | split_0_train_863 | [
{
"id": "split_0_train_863_passage",
"type": "progene_text",
"text": [
"A Haemophilus influenzae gene that encodes a membrane bound 3-deoxy-D-manno-octulosonic acid ( Kdo ) kinase ."
],
"offsets": [
[
0,
109
]
]
}
]
| [
{
"id": "split_0_train_1177_entity",
"type": "progene_text",
"text": [
"3-deoxy-D-manno-octulosonic acid ( Kdo ) kinase"
],
"offsets": [
[
60,
107
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_864 | split_0_train_864 | [
{
"id": "split_0_train_864_passage",
"type": "progene_text",
"text": [
"Possible involvement of kdo phosphorylation in bacterial virulence ."
],
"offsets": [
[
0,
68
]
]
}
]
| []
| []
| []
| []
|
split_0_train_865 | split_0_train_865 | [
{
"id": "split_0_train_865_passage",
"type": "progene_text",
"text": [
"The lipopolysaccharide of Haemophilus influenzae contains a single 3-deoxy-D-manno-octulosonic acid ( Kdo ) residue derivatized with either a phosphate or an ethanolamine pyrophosphate moiety at the 4-OH position ."
],
"offsets": [
[
0,
214
]
]
}
]
| []
| []
| []
| []
|
split_0_train_866 | split_0_train_866 | [
{
"id": "split_0_train_866_passage",
"type": "progene_text",
"text": [
"In previous studies , we identified a kinase unique to H. influenzae extracts that phosphorylates Kdo-lipid IV ( A ) , a key precursor of lipopolysaccharide in this organism ."
],
"offsets": [
[
0,
175
]
]
}
]
| [
{
"id": "split_0_train_1178_entity",
"type": "progene_text",
"text": [
"kinase"
],
"offsets": [
[
38,
44
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_867 | split_0_train_867 | [
{
"id": "split_0_train_867_passage",
"type": "progene_text",
"text": [
"We have now identified the gene encoding the Kdo kinase by using an expression cloning approach ."
],
"offsets": [
[
0,
97
]
]
}
]
| [
{
"id": "split_0_train_1179_entity",
"type": "progene_text",
"text": [
"Kdo kinase"
],
"offsets": [
[
45,
55
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_868 | split_0_train_868 | [
{
"id": "split_0_train_868_passage",
"type": "progene_text",
"text": [
"A cosmid library containing random DNA fragments from H. influenzae strain Rd was constructed in Escherichia coli ."
],
"offsets": [
[
0,
115
]
]
}
]
| []
| []
| []
| []
|
split_0_train_869 | split_0_train_869 | [
{
"id": "split_0_train_869_passage",
"type": "progene_text",
"text": [
"Extracts of 472 colonies containing individual hybrid cosmids were assayed for Kdo kinase activity ."
],
"offsets": [
[
0,
100
]
]
}
]
| [
{
"id": "split_0_train_1180_entity",
"type": "progene_text",
"text": [
"Kdo kinase"
],
"offsets": [
[
79,
89
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_870 | split_0_train_870 | [
{
"id": "split_0_train_870_passage",
"type": "progene_text",
"text": [
"A single hybrid cosmid directing expression of the kinase was found ."
],
"offsets": [
[
0,
69
]
]
}
]
| [
{
"id": "split_0_train_1181_entity",
"type": "progene_text",
"text": [
"kinase"
],
"offsets": [
[
51,
57
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_871 | split_0_train_871 | [
{
"id": "split_0_train_871_passage",
"type": "progene_text",
"text": [
"The kinase gene was identified by activity assays , sub - cloning , and DNA sequencing ."
],
"offsets": [
[
0,
88
]
]
}
]
| [
{
"id": "split_0_train_1182_entity",
"type": "progene_text",
"text": [
"kinase"
],
"offsets": [
[
4,
10
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_872 | split_0_train_872 | [
{
"id": "split_0_train_872_passage",
"type": "progene_text",
"text": [
"When the putative kinase gene was expressed in E. coli behind a T7 promoter , massive overproduction of kinase activity was achieved ( approximately 8000 - fold higher than in H. influenzae membranes ) ."
],
"offsets": [
[
0,
203
]
]
}
]
| [
{
"id": "split_0_train_1183_entity",
"type": "progene_text",
"text": [
"kinase"
],
"offsets": [
[
104,
110
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_873 | split_0_train_873 | [
{
"id": "split_0_train_873_passage",
"type": "progene_text",
"text": [
"The catalytic properties and the product generated by the overexpressed kinase , assayed with Kdo - lipid IV ( A ) as the substrate , were the same as observed with H. influenzae membranes ."
],
"offsets": [
[
0,
190
]
]
}
]
| [
{
"id": "split_0_train_1184_entity",
"type": "progene_text",
"text": [
"kinase"
],
"offsets": [
[
72,
78
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_874 | split_0_train_874 | [
{
"id": "split_0_train_874_passage",
"type": "progene_text",
"text": [
"Unexpectedly , the kinase gene was identical to a previously characterized open reading frame ( orfZ ) , which had been shown to be important for establishing bacteremia in an infant rat model ( Hood , D. W. , Deadman , M. E. , Allen , T. , Masoud , H. , Martin , A. , Brisson , J. R. , Fleischmann , R. , Venter , J. C. , Richards , J. C. , and Moxon , E. R. ( 1996 ) Mol. Microbiol. 22 , 951 - 965 ) ."
],
"offsets": [
[
0,
403
]
]
}
]
| [
{
"id": "split_0_train_1185_entity",
"type": "progene_text",
"text": [
"kinase"
],
"offsets": [
[
19,
25
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_875 | split_0_train_875 | [
{
"id": "split_0_train_875_passage",
"type": "progene_text",
"text": [
"However , based solely on the genome sequence of H. influenzae Rd , no biochemical function had been assigned to the product of orfZ , which we now designate kdkA ( \" Kdo kinase A \" ) ."
],
"offsets": [
[
0,
185
]
]
}
]
| [
{
"id": "split_0_train_1186_entity",
"type": "progene_text",
"text": [
"kdkA"
],
"offsets": [
[
158,
162
]
],
"normalized": []
},
{
"id": "split_0_train_1187_entity",
"type": "progene_text",
"text": [
"Kdo kinase A"
],
"offsets": [
[
167,
179
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_876 | split_0_train_876 | [
{
"id": "split_0_train_876_passage",
"type": "progene_text",
"text": [
"Although Kdo phosphorylation may be critical for bacterial virulence of H. influenzae , it does not appear to be required for growth ."
],
"offsets": [
[
0,
134
]
]
}
]
| []
| []
| []
| []
|
split_0_train_877 | split_0_train_877 | [
{
"id": "split_0_train_877_passage",
"type": "progene_text",
"text": [
"Studies in thoracic aortic graft infections : the development of a porcine model and a comparison of collagen - impregnated dacron grafts and cryopreserved allografts ."
],
"offsets": [
[
0,
168
]
]
}
]
| [
{
"id": "split_0_train_1188_entity",
"type": "progene_text",
"text": [
"collagen"
],
"offsets": [
[
101,
109
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_878 | split_0_train_878 | [
{
"id": "split_0_train_878_passage",
"type": "progene_text",
"text": [
"OBJECTIVE :"
],
"offsets": [
[
0,
11
]
]
}
]
| []
| []
| []
| []
|
split_0_train_879 | split_0_train_879 | [
{
"id": "split_0_train_879_passage",
"type": "progene_text",
"text": [
"A porcine model of thoracic aortic graft infection was created , and various anatomic sites and the timing of inoculation of the graft to induce infection were investigated ."
],
"offsets": [
[
0,
174
]
]
}
]
| []
| []
| []
| []
|
split_0_train_880 | split_0_train_880 | [
{
"id": "split_0_train_880_passage",
"type": "progene_text",
"text": [
"Ultimately , the ability of cryopreserved allograft to resist infection was compared with that of collagen - impregnated Dacron graft ."
],
"offsets": [
[
0,
135
]
]
}
]
| []
| []
| []
| []
|
split_0_train_881 | split_0_train_881 | [
{
"id": "split_0_train_881_passage",
"type": "progene_text",
"text": [
"METHODS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_882 | split_0_train_882 | [
{
"id": "split_0_train_882_passage",
"type": "progene_text",
"text": [
"Yorkshire pigs ( n = 16 ) underwent placement of an expanded polytetrafluoroethylene patch graft in the ascending aorta and the left atrial appendage ( phase I ) ."
],
"offsets": [
[
0,
163
]
]
}
]
| []
| []
| []
| []
|
split_0_train_883 | split_0_train_883 | [
{
"id": "split_0_train_883_passage",
"type": "progene_text",
"text": [
"Eight animals were immediately given a 50 - mL bolus ( 1 x 10 ( 8 ) cfu / mL ) of Staphylococcus aureus whereas the other 8 received the infusion 24 hours later ."
],
"offsets": [
[
0,
162
]
]
}
]
| []
| []
| []
| []
|
split_0_train_884 | split_0_train_884 | [
{
"id": "split_0_train_884_passage",
"type": "progene_text",
"text": [
"Animals were put to death 8 weeks later and the grafts were sterilely explanted and analyzed via microbiologic culture and standard histologic procedures for evidence of infection ."
],
"offsets": [
[
0,
181
]
]
}
]
| []
| []
| []
| []
|
split_0_train_885 | split_0_train_885 | [
{
"id": "split_0_train_885_passage",
"type": "progene_text",
"text": [
"The results displayed that the aortic graft and a delay of induced bacteremia of 24 hours were more reliable methods of producing infection ."
],
"offsets": [
[
0,
141
]
]
}
]
| []
| []
| []
| []
|
split_0_train_886 | split_0_train_886 | [
{
"id": "split_0_train_886_passage",
"type": "progene_text",
"text": [
"During phase II , 13 pigs were randomized to receive either a collagen - impregnated Dacron graft ( n = 6 ) or a cryopreserved allograft ( n = 7 ) in the ascending aortic position only and infusion of S aureus 24 hours after the operation ."
],
"offsets": [
[
0,
240
]
]
}
]
| [
{
"id": "split_0_train_1189_entity",
"type": "progene_text",
"text": [
"collagen"
],
"offsets": [
[
62,
70
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_887 | split_0_train_887 | [
{
"id": "split_0_train_887_passage",
"type": "progene_text",
"text": [
"The experiment then proceeded to completion ."
],
"offsets": [
[
0,
45
]
]
}
]
| []
| []
| []
| []
|
split_0_train_888 | split_0_train_888 | [
{
"id": "split_0_train_888_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_889 | split_0_train_889 | [
{
"id": "split_0_train_889_passage",
"type": "progene_text",
"text": [
"Phase I results displayed that use of an aortic graft and induced bacteremia 24 hours after the operation was a more reliable and reproducible method of producing infection ."
],
"offsets": [
[
0,
174
]
]
}
]
| []
| []
| []
| []
|
split_0_train_890 | split_0_train_890 | [
{
"id": "split_0_train_890_passage",
"type": "progene_text",
"text": [
"In phase II , graft infection was present in 38.5 % ( 5 / 13 ) of animals , with only 16.7 % ( 1 / 6 ) in the collagen - impregnated Dacron graft group and 57.2 % ( 4 / 7 ) in the cryopreserved allograft group becoming infected ."
],
"offsets": [
[
0,
229
]
]
}
]
| [
{
"id": "split_0_train_1190_entity",
"type": "progene_text",
"text": [
"collagen"
],
"offsets": [
[
110,
118
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_891 | split_0_train_891 | [
{
"id": "split_0_train_891_passage",
"type": "progene_text",
"text": [
"There was no significant difference between the collagen - impregnated Dacron graft and cryopreserved allograft groups in the incidences of thoracic aortic graft infections ( P = .27 , Fisher exact test ) ."
],
"offsets": [
[
0,
206
]
]
}
]
| [
{
"id": "split_0_train_1191_entity",
"type": "progene_text",
"text": [
"collagen"
],
"offsets": [
[
48,
56
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_892 | split_0_train_892 | [
{
"id": "split_0_train_892_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
]
| []
| []
| []
| []
|
split_0_train_893 | split_0_train_893 | [
{
"id": "split_0_train_893_passage",
"type": "progene_text",
"text": [
"This novel porcine model of thoracic aortic graft infection is a reproducible method for the investigation of thoracic aortic graft infections ."
],
"offsets": [
[
0,
144
]
]
}
]
| []
| []
| []
| []
|
split_0_train_894 | split_0_train_894 | [
{
"id": "split_0_train_894_passage",
"type": "progene_text",
"text": [
"The phase I study investigated the timing of the induced bacteremia and the most susceptible position of a graft ."
],
"offsets": [
[
0,
114
]
]
}
]
| []
| []
| []
| []
|
split_0_train_895 | split_0_train_895 | [
{
"id": "split_0_train_895_passage",
"type": "progene_text",
"text": [
"Phase II demonstrated that collagen - impregnated Dacron grafts are equivalent , if not superior , to cryopreserved allografts in resisting central vascular graft infections in the ascending aorta ."
],
"offsets": [
[
0,
198
]
]
}
]
| [
{
"id": "split_0_train_1192_entity",
"type": "progene_text",
"text": [
"collagen"
],
"offsets": [
[
27,
35
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_896 | split_0_train_896 | [
{
"id": "split_0_train_896_passage",
"type": "progene_text",
"text": [
"Drosophila ORC specifically binds to ACE3 , an origin of DNA replication control element ."
],
"offsets": [
[
0,
90
]
]
}
]
| [
{
"id": "split_0_train_1193_entity",
"type": "progene_text",
"text": [
"ORC"
],
"offsets": [
[
11,
14
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_897 | split_0_train_897 | [
{
"id": "split_0_train_897_passage",
"type": "progene_text",
"text": [
"In the yeast Saccharomyces cerevisiae , sequence - specific DNA binding by the origin recognition complex ( ORC ) is responsible for selecting origins of DNA replication ."
],
"offsets": [
[
0,
171
]
]
}
]
| [
{
"id": "split_0_train_1194_entity",
"type": "progene_text",
"text": [
"origin recognition complex"
],
"offsets": [
[
79,
105
]
],
"normalized": []
},
{
"id": "split_0_train_1195_entity",
"type": "progene_text",
"text": [
"ORC"
],
"offsets": [
[
108,
111
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_898 | split_0_train_898 | [
{
"id": "split_0_train_898_passage",
"type": "progene_text",
"text": [
"In metazoans , origin selection is poorly understood and it is unknown whether specific DNA binding by metazoan ORC controls replication ."
],
"offsets": [
[
0,
138
]
]
}
]
| [
{
"id": "split_0_train_1196_entity",
"type": "progene_text",
"text": [
"ORC"
],
"offsets": [
[
112,
115
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_899 | split_0_train_899 | [
{
"id": "split_0_train_899_passage",
"type": "progene_text",
"text": [
"To address this problem , we used in vivo and in vitro approaches to demonstrate that Drosophila ORC ( DmORC ) binds to replication elements that direct repeated initiation of replication to amplify the Drosophila chorion gene loci in the follicle cells of egg chambers ."
],
"offsets": [
[
0,
271
]
]
}
]
| [
{
"id": "split_0_train_1197_entity",
"type": "progene_text",
"text": [
"ORC"
],
"offsets": [
[
97,
100
]
],
"normalized": []
},
{
"id": "split_0_train_1198_entity",
"type": "progene_text",
"text": [
"DmORC"
],
"offsets": [
[
103,
108
]
],
"normalized": []
}
]
| []
| []
| []
|
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