id
stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
split_0_train_600 | split_0_train_600 | [
{
"id": "split_0_train_600_passage",
"type": "progene_text",
"text": [
"The alpha4GnT gene is located at chromosome 3p14.3 , and its transcripts are expressed in the stomach and pancreas ."
],
"offsets": [
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0,
116
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]
}
] | [
{
"id": "split_0_train_784_entity",
"type": "progene_text",
"text": [
"alpha4GnT"
],
"offsets": [
[
4,
13
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_601 | split_0_train_601 | [
{
"id": "split_0_train_601_passage",
"type": "progene_text",
"text": [
"An in vitro GlcNAc transferase assay by using a soluble alpha4GnT revealed that alpha1,4 - linked GlcNAc residues are transferred most efficiently to core 2 branched O-glycans ( Galbeta1 --> 4GlcNAcbeta1 --> 6 ( Galbeta1 --> 3 ) GalNAc ) , forming GlcNAcalpha1 --> 4Galbeta1 --> 4GlcNAcbeta1 --> 6 ( GlcNAca lpha1 --> 4Galbeta1- -> 3 ) GalNAc ."
],
"offsets": [
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0,
344
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]
}
] | [
{
"id": "split_0_train_785_entity",
"type": "progene_text",
"text": [
"GlcNAc transferase"
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12,
30
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{
"id": "split_0_train_786_entity",
"type": "progene_text",
"text": [
"alpha4GnT"
],
"offsets": [
[
56,
65
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_602 | split_0_train_602 | [
{
"id": "split_0_train_602_passage",
"type": "progene_text",
"text": [
"Transfection of alpha4GnT cDNA into gastric adenocarcinoma AGS cells produced class III mucin , indicating that alpha4GnT is responsible for the formation of class III Con A reactivity ."
],
"offsets": [
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0,
186
]
]
}
] | [
{
"id": "split_0_train_787_entity",
"type": "progene_text",
"text": [
"alpha4GnT"
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16,
25
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{
"id": "split_0_train_788_entity",
"type": "progene_text",
"text": [
"class III mucin"
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78,
93
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},
{
"id": "split_0_train_789_entity",
"type": "progene_text",
"text": [
"alpha4GnT"
],
"offsets": [
[
112,
121
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_603 | split_0_train_603 | [
{
"id": "split_0_train_603_passage",
"type": "progene_text",
"text": [
"These results indicate that the alpha4GnT is a glycosyltransferase that forms alpha1 , 4 - linked GlcNAc residues , preferentially in O-glycans ."
],
"offsets": [
[
0,
145
]
]
}
] | [
{
"id": "split_0_train_790_entity",
"type": "progene_text",
"text": [
"alpha4GnT"
],
"offsets": [
[
32,
41
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_604 | split_0_train_604 | [
{
"id": "split_0_train_604_passage",
"type": "progene_text",
"text": [
"Tax protein of HTLV-1 inhibits CBP / p300 - mediated transcription by interfering with recruitment of CBP / p300 onto DNA element of E-box or p53 binding site ."
],
"offsets": [
[
0,
160
]
]
}
] | [
{
"id": "split_0_train_791_entity",
"type": "progene_text",
"text": [
"Tax"
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0,
3
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{
"id": "split_0_train_792_entity",
"type": "progene_text",
"text": [
"CBP"
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31,
34
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"normalized": []
},
{
"id": "split_0_train_793_entity",
"type": "progene_text",
"text": [
"p300"
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37,
41
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},
{
"id": "split_0_train_794_entity",
"type": "progene_text",
"text": [
"CBP"
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102,
105
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},
{
"id": "split_0_train_795_entity",
"type": "progene_text",
"text": [
"p300"
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108,
112
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"normalized": []
},
{
"id": "split_0_train_796_entity",
"type": "progene_text",
"text": [
"p53"
],
"offsets": [
[
142,
145
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_605 | split_0_train_605 | [
{
"id": "split_0_train_605_passage",
"type": "progene_text",
"text": [
"Tax protein of human T-cell leukemia virus type 1 ( HTLV-1 ) is a potent transcriptional regulator which can activate or repress specific cellular genes and has been proposed to contribute to leukemogenic processes in adult T-cell leukemia ."
],
"offsets": [
[
0,
241
]
]
}
] | [
{
"id": "split_0_train_797_entity",
"type": "progene_text",
"text": [
"Tax"
],
"offsets": [
[
0,
3
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_606 | split_0_train_606 | [
{
"id": "split_0_train_606_passage",
"type": "progene_text",
"text": [
"The molecular mechanism of Tax - mediated trans - activation has been well investigated ."
],
"offsets": [
[
0,
89
]
]
}
] | [
{
"id": "split_0_train_798_entity",
"type": "progene_text",
"text": [
"Tax"
],
"offsets": [
[
27,
30
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_607 | split_0_train_607 | [
{
"id": "split_0_train_607_passage",
"type": "progene_text",
"text": [
"However , trans-repression by Tax remains to be studied in detail , although it is known to require a specific DNA element such as E-box or p53 binding site ."
],
"offsets": [
[
0,
158
]
]
}
] | [
{
"id": "split_0_train_799_entity",
"type": "progene_text",
"text": [
"Tax"
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"offsets": [
[
30,
33
]
],
"normalized": []
},
{
"id": "split_0_train_800_entity",
"type": "progene_text",
"text": [
"p53"
],
"offsets": [
[
140,
143
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_608 | split_0_train_608 | [
{
"id": "split_0_train_608_passage",
"type": "progene_text",
"text": [
"Examining possible mechanisms of trans-repression , we found that co - expression of E47 and p300 activated E-box dependent transcription and this activation was efficiently repressed by Tax ."
],
"offsets": [
[
0,
192
]
]
}
] | [
{
"id": "split_0_train_801_entity",
"type": "progene_text",
"text": [
"E47"
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"offsets": [
[
85,
88
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],
"normalized": []
},
{
"id": "split_0_train_802_entity",
"type": "progene_text",
"text": [
"p300"
],
"offsets": [
[
93,
97
]
],
"normalized": []
},
{
"id": "split_0_train_803_entity",
"type": "progene_text",
"text": [
"Tax"
],
"offsets": [
[
187,
190
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_609 | split_0_train_609 | [
{
"id": "split_0_train_609_passage",
"type": "progene_text",
"text": [
"In this system , Tax bound to p300 and decreased the level of p300 complexed on the E-box element ."
],
"offsets": [
[
0,
99
]
]
}
] | [
{
"id": "split_0_train_804_entity",
"type": "progene_text",
"text": [
"Tax"
],
"offsets": [
[
17,
20
]
],
"normalized": []
},
{
"id": "split_0_train_805_entity",
"type": "progene_text",
"text": [
"p300"
],
"offsets": [
[
30,
34
]
],
"normalized": []
},
{
"id": "split_0_train_806_entity",
"type": "progene_text",
"text": [
"p300"
],
"offsets": [
[
62,
66
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_610 | split_0_train_610 | [
{
"id": "split_0_train_610_passage",
"type": "progene_text",
"text": [
"Similarly , Tax inhibited transcription directed by p53 and CBP , reducing the level of CBP on the p53 binding site ."
],
"offsets": [
[
0,
117
]
]
}
] | [
{
"id": "split_0_train_807_entity",
"type": "progene_text",
"text": [
"Tax"
],
"offsets": [
[
12,
15
]
],
"normalized": []
},
{
"id": "split_0_train_808_entity",
"type": "progene_text",
"text": [
"p53"
],
"offsets": [
[
52,
55
]
],
"normalized": []
},
{
"id": "split_0_train_809_entity",
"type": "progene_text",
"text": [
"CBP"
],
"offsets": [
[
60,
63
]
],
"normalized": []
},
{
"id": "split_0_train_810_entity",
"type": "progene_text",
"text": [
"CBP"
],
"offsets": [
[
88,
91
]
],
"normalized": []
},
{
"id": "split_0_train_811_entity",
"type": "progene_text",
"text": [
"p53"
],
"offsets": [
[
99,
102
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_611 | split_0_train_611 | [
{
"id": "split_0_train_611_passage",
"type": "progene_text",
"text": [
"These results indicate that Tax interferes with recruitment of CBP / p300 into protein complexes on E-box and p53 binding site through its binding to CBP / p300 ."
],
"offsets": [
[
0,
162
]
]
}
] | [
{
"id": "split_0_train_812_entity",
"type": "progene_text",
"text": [
"Tax"
],
"offsets": [
[
28,
31
]
],
"normalized": []
},
{
"id": "split_0_train_813_entity",
"type": "progene_text",
"text": [
"CBP"
],
"offsets": [
[
63,
66
]
],
"normalized": []
},
{
"id": "split_0_train_814_entity",
"type": "progene_text",
"text": [
"p300"
],
"offsets": [
[
69,
73
]
],
"normalized": []
},
{
"id": "split_0_train_815_entity",
"type": "progene_text",
"text": [
"p53"
],
"offsets": [
[
110,
113
]
],
"normalized": []
},
{
"id": "split_0_train_816_entity",
"type": "progene_text",
"text": [
"CBP"
],
"offsets": [
[
150,
153
]
],
"normalized": []
},
{
"id": "split_0_train_817_entity",
"type": "progene_text",
"text": [
"p300"
],
"offsets": [
[
156,
160
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_612 | split_0_train_612 | [
{
"id": "split_0_train_612_passage",
"type": "progene_text",
"text": [
"In contrast to these findings , we observed that Tax increased the level of CBP on the viral 21 - bp enhancer which is trans - activated by Tax ."
],
"offsets": [
[
0,
145
]
]
}
] | [
{
"id": "split_0_train_818_entity",
"type": "progene_text",
"text": [
"Tax"
],
"offsets": [
[
49,
52
]
],
"normalized": []
},
{
"id": "split_0_train_819_entity",
"type": "progene_text",
"text": [
"CBP"
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"offsets": [
[
76,
79
]
],
"normalized": []
},
{
"id": "split_0_train_820_entity",
"type": "progene_text",
"text": [
"Tax"
],
"offsets": [
[
140,
143
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_613 | split_0_train_613 | [
{
"id": "split_0_train_613_passage",
"type": "progene_text",
"text": [
"From these observations , we propose a universal mechanism for Tax - mediated trans - repression and trans - activation of transcription in which Tax binds to CBP / p300 and determines the accessibility of CBP / p300 to protein complexes on specific DNA element ."
],
"offsets": [
[
0,
263
]
]
}
] | [
{
"id": "split_0_train_821_entity",
"type": "progene_text",
"text": [
"Tax"
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"offsets": [
[
63,
66
]
],
"normalized": []
},
{
"id": "split_0_train_822_entity",
"type": "progene_text",
"text": [
"Tax"
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"offsets": [
[
146,
149
]
],
"normalized": []
},
{
"id": "split_0_train_823_entity",
"type": "progene_text",
"text": [
"CBP"
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"offsets": [
[
159,
162
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],
"normalized": []
},
{
"id": "split_0_train_824_entity",
"type": "progene_text",
"text": [
"p300"
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"offsets": [
[
165,
169
]
],
"normalized": []
},
{
"id": "split_0_train_825_entity",
"type": "progene_text",
"text": [
"CBP"
],
"offsets": [
[
206,
209
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],
"normalized": []
},
{
"id": "split_0_train_826_entity",
"type": "progene_text",
"text": [
"p300"
],
"offsets": [
[
212,
216
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_614 | split_0_train_614 | [
{
"id": "split_0_train_614_passage",
"type": "progene_text",
"text": [
"AND-34 , a novel p130Cas - binding thymic stromal cell protein regulated by adhesion and inflammatory cytokines ."
],
"offsets": [
[
0,
113
]
]
}
] | [
{
"id": "split_0_train_827_entity",
"type": "progene_text",
"text": [
"AND-34"
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"offsets": [
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0,
6
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"normalized": []
},
{
"id": "split_0_train_828_entity",
"type": "progene_text",
"text": [
"p130Cas"
],
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[
17,
24
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"normalized": []
},
{
"id": "split_0_train_829_entity",
"type": "progene_text",
"text": [
"cytokines"
],
"offsets": [
[
102,
111
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_615 | split_0_train_615 | [
{
"id": "split_0_train_615_passage",
"type": "progene_text",
"text": [
"We have characterized a novel cDNA whose steady state mRNA levels rise in the thymus 2 to 6 h following the induction of CD4 + CD8 + thymocyte apoptosis by in vivo cross - linking of CD3 epsilon ."
],
"offsets": [
[
0,
196
]
]
}
] | [
{
"id": "split_0_train_830_entity",
"type": "progene_text",
"text": [
"CD4"
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[
121,
124
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],
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},
{
"id": "split_0_train_831_entity",
"type": "progene_text",
"text": [
"CD8"
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[
127,
130
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],
"normalized": []
},
{
"id": "split_0_train_832_entity",
"type": "progene_text",
"text": [
"CD3 epsilon"
],
"offsets": [
[
183,
194
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_616 | split_0_train_616 | [
{
"id": "split_0_train_616_passage",
"type": "progene_text",
"text": [
"This cDNA , AND-34-1 , contains an open reading frame ( ORF ) encoding a protein with an amino - terminal Src homology 2 ( SH2 ) domain and a carboxyl - terminal domain homologous to GDP - exchange factors ( GEFs ) ."
],
"offsets": [
[
0,
216
]
]
}
] | [
{
"id": "split_0_train_833_entity",
"type": "progene_text",
"text": [
"AND-34-1"
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"offsets": [
[
12,
20
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],
"normalized": []
},
{
"id": "split_0_train_834_entity",
"type": "progene_text",
"text": [
"Src"
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[
106,
109
]
],
"normalized": []
},
{
"id": "split_0_train_835_entity",
"type": "progene_text",
"text": [
"GDP - exchange factors"
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[
183,
205
]
],
"normalized": []
},
{
"id": "split_0_train_836_entity",
"type": "progene_text",
"text": [
"GEFs"
],
"offsets": [
[
208,
212
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_617 | split_0_train_617 | [
{
"id": "split_0_train_617_passage",
"type": "progene_text",
"text": [
"Northern analysis demonstrates widespread expression of the AND-34 gene ."
],
"offsets": [
[
0,
73
]
]
}
] | [
{
"id": "split_0_train_837_entity",
"type": "progene_text",
"text": [
"AND-34"
],
"offsets": [
[
60,
66
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_618 | split_0_train_618 | [
{
"id": "split_0_train_618_passage",
"type": "progene_text",
"text": [
"Anti - CD3 epsilon treatment induces up - regulation of the AND-34 mRNA levels in total thymic RNA but not in RNA from purified thymocytes , suggesting that this transcript is derived from a thymic stromal cell population ."
],
"offsets": [
[
0,
223
]
]
}
] | [
{
"id": "split_0_train_838_entity",
"type": "progene_text",
"text": [
"CD3 epsilon"
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"offsets": [
[
7,
18
]
],
"normalized": []
},
{
"id": "split_0_train_839_entity",
"type": "progene_text",
"text": [
"AND-34"
],
"offsets": [
[
60,
66
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_619 | split_0_train_619 | [
{
"id": "split_0_train_619_passage",
"type": "progene_text",
"text": [
"IL-1 and TNF increase AND-34 transcript levels in thymic cortical reticular , thymic nurse , and fibroblast cell lines ."
],
"offsets": [
[
0,
120
]
]
}
] | [
{
"id": "split_0_train_840_entity",
"type": "progene_text",
"text": [
"IL-1"
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"offsets": [
[
0,
4
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},
{
"id": "split_0_train_841_entity",
"type": "progene_text",
"text": [
"TNF"
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9,
12
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],
"normalized": []
},
{
"id": "split_0_train_842_entity",
"type": "progene_text",
"text": [
"AND-34"
],
"offsets": [
[
22,
28
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_620 | split_0_train_620 | [
{
"id": "split_0_train_620_passage",
"type": "progene_text",
"text": [
"In the thymic cortical reticular cell line , IL-1 and TNF induce a protein of the predicted 93 - kDa size reactive with anti - AND - 34 peptide antisera ."
],
"offsets": [
[
0,
154
]
]
}
] | [
{
"id": "split_0_train_843_entity",
"type": "progene_text",
"text": [
"IL-1"
],
"offsets": [
[
45,
49
]
],
"normalized": []
},
{
"id": "split_0_train_844_entity",
"type": "progene_text",
"text": [
"TNF"
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"offsets": [
[
54,
57
]
],
"normalized": []
},
{
"id": "split_0_train_845_entity",
"type": "progene_text",
"text": [
"AND - 34"
],
"offsets": [
[
127,
135
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_621 | split_0_train_621 | [
{
"id": "split_0_train_621_passage",
"type": "progene_text",
"text": [
"Fifteen minutes of serum stimulation of vanadate - pretreated AND-34-1 - transfected NIH3T3 fibroblasts induces tyrosine phosphorylation of AND-34 as well as coprecipitating 95 - , 125 - , and 130 - kDa proteins ."
],
"offsets": [
[
0,
213
]
]
}
] | [
{
"id": "split_0_train_846_entity",
"type": "progene_text",
"text": [
"AND-34-1"
],
"offsets": [
[
62,
70
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],
"normalized": []
},
{
"id": "split_0_train_847_entity",
"type": "progene_text",
"text": [
"AND-34"
],
"offsets": [
[
140,
146
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_622 | split_0_train_622 | [
{
"id": "split_0_train_622_passage",
"type": "progene_text",
"text": [
"One of these tyrosine phosphorylated proteins is identified as p130Cas ( Crk - associated substrate ) , a signaling molecule previously known to bind to a GDP - exchange factor ( C3G ) and inducibly associate with the focal adhesion complex ."
],
"offsets": [
[
0,
242
]
]
}
] | [
{
"id": "split_0_train_848_entity",
"type": "progene_text",
"text": [
"p130Cas"
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[
63,
70
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],
"normalized": []
},
{
"id": "split_0_train_849_entity",
"type": "progene_text",
"text": [
"Crk - associated substrate"
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[
73,
99
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"normalized": []
},
{
"id": "split_0_train_850_entity",
"type": "progene_text",
"text": [
"GDP - exchange factor"
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[
155,
176
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],
"normalized": []
},
{
"id": "split_0_train_851_entity",
"type": "progene_text",
"text": [
"C3G"
],
"offsets": [
[
179,
182
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_623 | split_0_train_623 | [
{
"id": "split_0_train_623_passage",
"type": "progene_text",
"text": [
"Consistent with such an association , AND-34 tyrosine phosphorylation is induced following adherence of trypsinized fibroblasts to fibronectin or poly-L - lysine - coated surfaces ."
],
"offsets": [
[
0,
181
]
]
}
] | [
{
"id": "split_0_train_852_entity",
"type": "progene_text",
"text": [
"AND-34"
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[
38,
44
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},
{
"id": "split_0_train_853_entity",
"type": "progene_text",
"text": [
"fibronectin"
],
"offsets": [
[
131,
142
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_624 | split_0_train_624 | [
{
"id": "split_0_train_624_passage",
"type": "progene_text",
"text": [
"[ Glucagonoma -- somatostatinoma ]"
],
"offsets": [
[
0,
34
]
]
}
] | [] | [] | [] | [] |
split_0_train_625 | split_0_train_625 | [
{
"id": "split_0_train_625_passage",
"type": "progene_text",
"text": [
"Glucagonoma and somatostatinoma are tumors which produce the respective hormone ."
],
"offsets": [
[
0,
81
]
]
}
] | [] | [] | [] | [] |
split_0_train_626 | split_0_train_626 | [
{
"id": "split_0_train_626_passage",
"type": "progene_text",
"text": [
"When these peptides are also secreted into the circulation the clinical syndromes are characterized by the signs and symptoms due to hormone overproduction ."
],
"offsets": [
[
0,
157
]
]
}
] | [] | [] | [] | [] |
split_0_train_627 | split_0_train_627 | [
{
"id": "split_0_train_627_passage",
"type": "progene_text",
"text": [
"In case of the glucagonoma - syndrome diabetes and typical skin lesions are dominating while patients with the somatostatinoma syndrome have diabetes frequently associated with steatorrhea ."
],
"offsets": [
[
0,
190
]
]
}
] | [] | [] | [] | [] |
split_0_train_628 | split_0_train_628 | [
{
"id": "split_0_train_628_passage",
"type": "progene_text",
"text": [
"Surgical resection of the tumor and its metastases as far as possible is the therapy of choice ."
],
"offsets": [
[
0,
96
]
]
}
] | [] | [] | [] | [] |
split_0_train_629 | split_0_train_629 | [
{
"id": "split_0_train_629_passage",
"type": "progene_text",
"text": [
"For symptomatic relief and inhibition of the growth of the metastases interferon-a and somatostatin analogues can be employed ."
],
"offsets": [
[
0,
127
]
]
}
] | [
{
"id": "split_0_train_854_entity",
"type": "progene_text",
"text": [
"interferon-a"
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"offsets": [
[
70,
82
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],
"normalized": []
},
{
"id": "split_0_train_855_entity",
"type": "progene_text",
"text": [
"somatostatin"
],
"offsets": [
[
87,
99
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_630 | split_0_train_630 | [
{
"id": "split_0_train_630_passage",
"type": "progene_text",
"text": [
"Prognostic value of MIBG imaging in idiopathic dilated cardiomyopathy ."
],
"offsets": [
[
0,
71
]
]
}
] | [] | [] | [] | [] |
split_0_train_631 | split_0_train_631 | [
{
"id": "split_0_train_631_passage",
"type": "progene_text",
"text": [
"Alterations of cardiac sympathetic innervation are likely to contribute to fatal outcomes in patients with heart failure ."
],
"offsets": [
[
0,
122
]
]
}
] | [] | [] | [] | [] |
split_0_train_632 | split_0_train_632 | [
{
"id": "split_0_train_632_passage",
"type": "progene_text",
"text": [
"These alterations can be evaluated noninvasively by 123I-metaiodoben-zylguanidine ( MIBG ) imaging ."
],
"offsets": [
[
0,
100
]
]
}
] | [] | [] | [] | [] |
split_0_train_633 | split_0_train_633 | [
{
"id": "split_0_train_633_passage",
"type": "progene_text",
"text": [
"METHODS :"
],
"offsets": [
[
0,
9
]
]
}
] | [] | [] | [] | [] |
split_0_train_634 | split_0_train_634 | [
{
"id": "split_0_train_634_passage",
"type": "progene_text",
"text": [
"The hypothesis that impaired cardiac sympathetic innervation , as assessed using MIBG imaging , is related to adverse outcomes was tested in 112 patients with heart failure resulting from idiopathic cardiomyopathy ."
],
"offsets": [
[
0,
215
]
]
}
] | [] | [] | [] | [] |
split_0_train_635 | split_0_train_635 | [
{
"id": "split_0_train_635_passage",
"type": "progene_text",
"text": [
"Main inclusion criteria were New York Heart Association classes II-IV and radionuclide left ventricular ejection fraction ( LVEF ) < 40 % ."
],
"offsets": [
[
0,
139
]
]
}
] | [] | [] | [] | [] |
split_0_train_636 | split_0_train_636 | [
{
"id": "split_0_train_636_passage",
"type": "progene_text",
"text": [
"Patients were assessed for cardiac MIBG uptake , circulating norepinephrine concentration , LVEF , peak Vo2 , x - ray cardiothoracic ratio , M-mode echographic end - diastolic diameter and right - sided heart catheterization parameters ."
],
"offsets": [
[
0,
237
]
]
}
] | [] | [] | [] | [] |
split_0_train_637 | split_0_train_637 | [
{
"id": "split_0_train_637_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
] | [] | [] | [] | [] |
split_0_train_638 | split_0_train_638 | [
{
"id": "split_0_train_638_passage",
"type": "progene_text",
"text": [
"During a mean follow - up of 27 +/- 20 mo , 19 patients had transplants , 25 died of cardiac death ( 8 sudden deaths ) , 2 died of noncardiac death and 66 survived without transplantation ."
],
"offsets": [
[
0,
189
]
]
}
] | [] | [] | [] | [] |
split_0_train_639 | split_0_train_639 | [
{
"id": "split_0_train_639_passage",
"type": "progene_text",
"text": [
"The only independent predictors for mortality were low MIBG uptake ( P < 0.001 ) and LVEF ( P = 0.02 ) when using multivariate discriminant analysis ."
],
"offsets": [
[
0,
150
]
]
}
] | [] | [] | [] | [] |
split_0_train_640 | split_0_train_640 | [
{
"id": "split_0_train_640_passage",
"type": "progene_text",
"text": [
"Moreover , MIBG uptake ( P < 0.001 ) and circulating norepinephrine concentration ( P = 0.001 ) were the only independent predictors for life duration when using multivariate life table analysis ."
],
"offsets": [
[
0,
196
]
]
}
] | [] | [] | [] | [] |
split_0_train_641 | split_0_train_641 | [
{
"id": "split_0_train_641_passage",
"type": "progene_text",
"text": [
"CONCLUSION :"
],
"offsets": [
[
0,
12
]
]
}
] | [] | [] | [] | [] |
split_0_train_642 | split_0_train_642 | [
{
"id": "split_0_train_642_passage",
"type": "progene_text",
"text": [
"Impaired cardiac adrenergic innervation as assessed by MIBG imaging is strongly related to mortality ."
],
"offsets": [
[
0,
102
]
]
}
] | [] | [] | [] | [] |
split_0_train_643 | split_0_train_643 | [
{
"id": "split_0_train_643_passage",
"type": "progene_text",
"text": [
"MIBG imaging may help risk stratify patients with heart failure resulting from idiopathic dilated cardiomyopathy ."
],
"offsets": [
[
0,
114
]
]
}
] | [] | [] | [] | [] |
split_0_train_644 | split_0_train_644 | [
{
"id": "split_0_train_644_passage",
"type": "progene_text",
"text": [
"Activation of silent replication origins at autonomously replicating sequence elements near the HML locus in budding yeast ."
],
"offsets": [
[
0,
124
]
]
}
] | [] | [] | [] | [] |
split_0_train_645 | split_0_train_645 | [
{
"id": "split_0_train_645_passage",
"type": "progene_text",
"text": [
"In the budding yeast , Saccharomyces cerevisiae , replicators can function outside the chromosome as autonomously replicating sequence ( ARS ) elements ; however , within chromosome III , certain ARSs near the transcriptionally silent HML locus show no replication origin activity ."
],
"offsets": [
[
0,
282
]
]
}
] | [] | [] | [] | [] |
split_0_train_646 | split_0_train_646 | [
{
"id": "split_0_train_646_passage",
"type": "progene_text",
"text": [
"Two of these ARSs comprise the transcriptional silencers E ( ARS301 ) and I ( ARS302 ) ."
],
"offsets": [
[
0,
88
]
]
}
] | [] | [] | [] | [] |
split_0_train_647 | split_0_train_647 | [
{
"id": "split_0_train_647_passage",
"type": "progene_text",
"text": [
"Another , ARS303 , resides between HML and the CHA1 gene , and its function is not known ."
],
"offsets": [
[
0,
90
]
]
}
] | [
{
"id": "split_0_train_856_entity",
"type": "progene_text",
"text": [
"CHA1"
],
"offsets": [
[
47,
51
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_648 | split_0_train_648 | [
{
"id": "split_0_train_648_passage",
"type": "progene_text",
"text": [
"Here we further localized and characterized ARS303 and in the process discovered a new ARS , ARS320 ."
],
"offsets": [
[
0,
101
]
]
}
] | [] | [] | [] | [] |
split_0_train_649 | split_0_train_649 | [
{
"id": "split_0_train_649_passage",
"type": "progene_text",
"text": [
"Both ARS303 and ARS320 are competent as chromosomal replication origins since origin activity was seen when they were inserted at a different position in chromosome III ."
],
"offsets": [
[
0,
170
]
]
}
] | [] | [] | [] | [] |
split_0_train_650 | split_0_train_650 | [
{
"id": "split_0_train_650_passage",
"type": "progene_text",
"text": [
"However , at their native locations , where the two ARSs are in a cluster with ARS302 , the I silencer , no replication origin activity was detected regardless of yeast mating type , special growth conditions that induce the transcriptionally repressed CHA1 gene , trans - acting mutations that abrogate transcriptional silencing at HML ( sir3 , orc5 ) , or cis - acting mutations that delete the E and I silencers containing ARS elements ."
],
"offsets": [
[
0,
440
]
]
}
] | [
{
"id": "split_0_train_857_entity",
"type": "progene_text",
"text": [
"CHA1"
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"offsets": [
[
253,
257
]
],
"normalized": []
},
{
"id": "split_0_train_858_entity",
"type": "progene_text",
"text": [
"sir3"
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"offsets": [
[
339,
343
]
],
"normalized": []
},
{
"id": "split_0_train_859_entity",
"type": "progene_text",
"text": [
"orc5"
],
"offsets": [
[
346,
350
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_651 | split_0_train_651 | [
{
"id": "split_0_train_651_passage",
"type": "progene_text",
"text": [
"These results suggest that , for the HML ARS cluster ( ARS303 , ARS320 , and ARS302 ) , inactivity of origins is independent of local transcriptional silencing , even though origins and silencers share key cis - and trans - acting components ."
],
"offsets": [
[
0,
243
]
]
}
] | [] | [] | [] | [] |
split_0_train_652 | split_0_train_652 | [
{
"id": "split_0_train_652_passage",
"type": "progene_text",
"text": [
"Surprisingly , deletion of active replication origins located 25 kb ( ORI305 ) and 59 kb ( ORI306 ) away led to detection of replication origin function at the HML ARS cluster , as well as at ARS301 , the E silencer ."
],
"offsets": [
[
0,
217
]
]
}
] | [] | [] | [] | [] |
split_0_train_653 | split_0_train_653 | [
{
"id": "split_0_train_653_passage",
"type": "progene_text",
"text": [
"Thus , replication origin silencing at HML ARSs is mediated by active replication origins residing at long distances from HML in the chromosome ."
],
"offsets": [
[
0,
145
]
]
}
] | [] | [] | [] | [] |
split_0_train_654 | split_0_train_654 | [
{
"id": "split_0_train_654_passage",
"type": "progene_text",
"text": [
"The distal active origins are known to fire early in S phase , and we propose that their inactivation delays replication fork arrival at HML , providing additional time for HML ARSs to fire as origins ."
],
"offsets": [
[
0,
202
]
]
}
] | [] | [] | [] | [] |
split_0_train_655 | split_0_train_655 | [
{
"id": "split_0_train_655_passage",
"type": "progene_text",
"text": [
"Novel human and mouse homologs of Saccharomyces cerevisiae DNA polymerase eta ."
],
"offsets": [
[
0,
79
]
]
}
] | [
{
"id": "split_0_train_860_entity",
"type": "progene_text",
"text": [
"DNA polymerase eta"
],
"offsets": [
[
59,
77
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_656 | split_0_train_656 | [
{
"id": "split_0_train_656_passage",
"type": "progene_text",
"text": [
"The Saccharomyces cerevisiae RAD30 gene encodes a novel eukaryotic DNA polymerase , pol eta that is able to replicate across cis-syn cyclobutane pyrimidine dimers both accurately and efficiently ."
],
"offsets": [
[
0,
196
]
]
}
] | [
{
"id": "split_0_train_861_entity",
"type": "progene_text",
"text": [
"RAD30"
],
"offsets": [
[
29,
34
]
],
"normalized": []
},
{
"id": "split_0_train_862_entity",
"type": "progene_text",
"text": [
"DNA polymerase"
],
"offsets": [
[
67,
81
]
],
"normalized": []
},
{
"id": "split_0_train_863_entity",
"type": "progene_text",
"text": [
"pol eta"
],
"offsets": [
[
84,
91
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_657 | split_0_train_657 | [
{
"id": "split_0_train_657_passage",
"type": "progene_text",
"text": [
"Very recently , a human homolog of RAD30 was identified , mutations in which result in the sunlight - sensitive , cancer - prone , Xeroderma pigmentosum variant group phenotype ."
],
"offsets": [
[
0,
178
]
]
}
] | [
{
"id": "split_0_train_864_entity",
"type": "progene_text",
"text": [
"RAD30"
],
"offsets": [
[
35,
40
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_658 | split_0_train_658 | [
{
"id": "split_0_train_658_passage",
"type": "progene_text",
"text": [
"We report here the cloning and localization of a second human homolog of RAD30 ."
],
"offsets": [
[
0,
80
]
]
}
] | [
{
"id": "split_0_train_865_entity",
"type": "progene_text",
"text": [
"RAD30"
],
"offsets": [
[
73,
78
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_659 | split_0_train_659 | [
{
"id": "split_0_train_659_passage",
"type": "progene_text",
"text": [
"Interestingly , RAD30B is localized on chromosome 18q21.1 in a region that is often implicated in the etiology of many human cancers ."
],
"offsets": [
[
0,
134
]
]
}
] | [
{
"id": "split_0_train_866_entity",
"type": "progene_text",
"text": [
"RAD30B"
],
"offsets": [
[
16,
22
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_660 | split_0_train_660 | [
{
"id": "split_0_train_660_passage",
"type": "progene_text",
"text": [
"The mouse homolog ( Rad30b ) is located on chromosome 18E2 ."
],
"offsets": [
[
0,
60
]
]
}
] | [
{
"id": "split_0_train_867_entity",
"type": "progene_text",
"text": [
"Rad30b"
],
"offsets": [
[
20,
26
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_661 | split_0_train_661 | [
{
"id": "split_0_train_661_passage",
"type": "progene_text",
"text": [
"The human RAD30B and mouse Rad30b mRNA transcripts , like many repair proteins , are highly expressed in the testis ."
],
"offsets": [
[
0,
117
]
]
}
] | [
{
"id": "split_0_train_868_entity",
"type": "progene_text",
"text": [
"RAD30B"
],
"offsets": [
[
10,
16
]
],
"normalized": []
},
{
"id": "split_0_train_869_entity",
"type": "progene_text",
"text": [
"Rad30b"
],
"offsets": [
[
27,
33
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_662 | split_0_train_662 | [
{
"id": "split_0_train_662_passage",
"type": "progene_text",
"text": [
"In situ hybridization analysis indicates that expression of mouse Rad30b occurs predominantly in postmeiotic round spermatids ."
],
"offsets": [
[
0,
127
]
]
}
] | [
{
"id": "split_0_train_870_entity",
"type": "progene_text",
"text": [
"Rad30b"
],
"offsets": [
[
66,
72
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_663 | split_0_train_663 | [
{
"id": "split_0_train_663_passage",
"type": "progene_text",
"text": [
"Database searches revealed genomic and EST sequences from other eukaryotes such as Aspergillus nidulans , Schizosaccharomyces pombe , Brugia malayi , Caenorhabditis elegans , Trypanosoma cruzi , Arabidopsis thaliana , and Drosophila melanogaster that also encode putative homologs of RAD30 , thereby suggesting that Rad30 - dependent translesion DNA synthesis is conserved within the eukaryotic kingdom ."
],
"offsets": [
[
0,
404
]
]
}
] | [
{
"id": "split_0_train_871_entity",
"type": "progene_text",
"text": [
"RAD30"
],
"offsets": [
[
284,
289
]
],
"normalized": []
},
{
"id": "split_0_train_872_entity",
"type": "progene_text",
"text": [
"Rad30"
],
"offsets": [
[
316,
321
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_664 | split_0_train_664 | [
{
"id": "split_0_train_664_passage",
"type": "progene_text",
"text": [
"An autoregulatory circuit affecting peptide signaling in Bacillus subtilis ."
],
"offsets": [
[
0,
76
]
]
}
] | [] | [] | [] | [] |
split_0_train_665 | split_0_train_665 | [
{
"id": "split_0_train_665_passage",
"type": "progene_text",
"text": [
"The competence and sporulation factor ( CSF ) of Bacillus subtilis is an extracellular pentapeptide produced from the product of phrC ."
],
"offsets": [
[
0,
135
]
]
}
] | [
{
"id": "split_0_train_873_entity",
"type": "progene_text",
"text": [
"competence and sporulation factor"
],
"offsets": [
[
4,
37
]
],
"normalized": []
},
{
"id": "split_0_train_874_entity",
"type": "progene_text",
"text": [
"CSF"
],
"offsets": [
[
40,
43
]
],
"normalized": []
},
{
"id": "split_0_train_875_entity",
"type": "progene_text",
"text": [
"phrC"
],
"offsets": [
[
129,
133
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_666 | split_0_train_666 | [
{
"id": "split_0_train_666_passage",
"type": "progene_text",
"text": [
"CSF has at least three activities : (i) at low concentrations , it stimulates expression of genes activated by the transcription factor ComA ; at higher concentrations , it (ii) inhibits expression of those same genes and (iii) stimulates sporulation ."
],
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[
0,
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]
}
] | [
{
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115,
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"ComA"
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136,
140
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}
] | [] | [] | [] |
split_0_train_667 | split_0_train_667 | [
{
"id": "split_0_train_667_passage",
"type": "progene_text",
"text": [
"Because the activities of CSF are concentration dependent , we measured the amount of extracellular CSF produced by cells ."
],
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[
0,
123
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}
] | [
{
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{
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"text": [
"CSF"
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100,
103
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}
] | [] | [] | [] |
split_0_train_668 | split_0_train_668 | [
{
"id": "split_0_train_668_passage",
"type": "progene_text",
"text": [
"We found that by mid - exponential phase , CSF accumulated to concentrations ( 1 to 5 nM ) that stimulate ComA - dependent gene expression ."
],
"offsets": [
[
0,
140
]
]
}
] | [
{
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43,
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{
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"text": [
"ComA"
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106,
110
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_669 | split_0_train_669 | [
{
"id": "split_0_train_669_passage",
"type": "progene_text",
"text": [
"Upon entry into stationary phase , CSF reached 50 to 100 nM , concentrations that stimulate sporulation and inhibit ComA - dependent gene expression ."
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0,
150
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}
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{
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"ComA"
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116,
120
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],
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}
] | [] | [] | [] |
split_0_train_670 | split_0_train_670 | [
{
"id": "split_0_train_670_passage",
"type": "progene_text",
"text": [
"Transcription of phrC was found to be controlled by two promoters : P1 , which precedes rapC , the gene upstream of phrC ; and P2 , which directs transcription of phrC only ."
],
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0,
174
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}
] | [
{
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17,
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{
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{
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"phrC"
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163,
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}
] | [] | [] | [] |
split_0_train_671 | split_0_train_671 | [
{
"id": "split_0_train_671_passage",
"type": "progene_text",
"text": [
"Both RapC and CSF were found to be part of autoregulatory loops that affect transcription from P1 , which we show is activated by ComA approximately P. RapC negatively regulates its own expression , presumably due to its ability to inhibit accumulation of ComA approximately P. CSF positively regulates its own expression , presumably due to its ability to inhibit RapC activity ."
],
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[
0,
380
]
]
}
] | [
{
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{
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130,
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152,
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256,
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278,
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{
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"text": [
"RapC"
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"offsets": [
[
365,
369
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_672 | split_0_train_672 | [
{
"id": "split_0_train_672_passage",
"type": "progene_text",
"text": [
"Transcription from P2 , which is controlled by the alternate sigma factor sigma ( H ) , increased as cells entered stationary phase , contributing to the increase in extracellular CSF at this time ."
],
"offsets": [
[
0,
198
]
]
}
] | [
{
"id": "split_0_train_896_entity",
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61,
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},
{
"id": "split_0_train_897_entity",
"type": "progene_text",
"text": [
"sigma ( H )"
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74,
85
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},
{
"id": "split_0_train_898_entity",
"type": "progene_text",
"text": [
"CSF"
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[
180,
183
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_673 | split_0_train_673 | [
{
"id": "split_0_train_673_passage",
"type": "progene_text",
"text": [
"In addition to controlling transcription of phrC , sigmaH appears to control expression of at least one other gene required for production of CSF ."
],
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0,
147
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]
}
] | [
{
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44,
48
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{
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"type": "progene_text",
"text": [
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51,
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},
{
"id": "split_0_train_901_entity",
"type": "progene_text",
"text": [
"CSF"
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"offsets": [
[
142,
145
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_674 | split_0_train_674 | [
{
"id": "split_0_train_674_passage",
"type": "progene_text",
"text": [
"The controversy of significance testing : misconceptions and alternatives ."
],
"offsets": [
[
0,
75
]
]
}
] | [] | [] | [] | [] |
split_0_train_675 | split_0_train_675 | [
{
"id": "split_0_train_675_passage",
"type": "progene_text",
"text": [
"The current debate about the merits of null hypothesis significance testing , even though provocative , is not particularly novel ."
],
"offsets": [
[
0,
131
]
]
}
] | [] | [] | [] | [] |
split_0_train_676 | split_0_train_676 | [
{
"id": "split_0_train_676_passage",
"type": "progene_text",
"text": [
"The significance testing approach has had defenders and opponents for decades , especially within the social sciences , where reliance on the use of significance testing has historically been heavy ."
],
"offsets": [
[
0,
199
]
]
}
] | [] | [] | [] | [] |
split_0_train_677 | split_0_train_677 | [
{
"id": "split_0_train_677_passage",
"type": "progene_text",
"text": [
"The primary concerns have been (1) the misuse of significance testing , (2) the misinterpretation of P values , and ( 3 ) the lack of accompanying statistics , such as effect sizes and confidence intervals , that would provide a broader picture into the researcher 's data analysis and interpretation ."
],
"offsets": [
[
0,
302
]
]
}
] | [] | [] | [] | [] |
split_0_train_678 | split_0_train_678 | [
{
"id": "split_0_train_678_passage",
"type": "progene_text",
"text": [
"This article presents the current thinking , both in favor and against , on significance testing , the virtually unanimous support for reporting effect sizes alongside P values , and the overall implications for practice and application ."
],
"offsets": [
[
0,
238
]
]
}
] | [] | [] | [] | [] |
split_0_train_679 | split_0_train_679 | [
{
"id": "split_0_train_679_passage",
"type": "progene_text",
"text": [
"Identification of SAS4 and SAS5 , two genes that regulate silencing in Saccharomyces cerevisiae ."
],
"offsets": [
[
0,
97
]
]
}
] | [
{
"id": "split_0_train_902_entity",
"type": "progene_text",
"text": [
"SAS4"
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"offsets": [
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18,
22
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],
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},
{
"id": "split_0_train_903_entity",
"type": "progene_text",
"text": [
"SAS5"
],
"offsets": [
[
27,
31
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_680 | split_0_train_680 | [
{
"id": "split_0_train_680_passage",
"type": "progene_text",
"text": [
"In Saccharomyces cerevisiae , chromatin - mediated silencing inactivates transcription of the genes at the HML and HMR cryptic mating - type loci and genes near telomeres ."
],
"offsets": [
[
0,
172
]
]
}
] | [] | [] | [] | [] |
split_0_train_681 | split_0_train_681 | [
{
"id": "split_0_train_681_passage",
"type": "progene_text",
"text": [
"Mutations in the Rap1p and Abf1p binding sites of the HMR-E silencer ( HMRa-e** ) result in a loss of silencing at HMR ."
],
"offsets": [
[
0,
120
]
]
}
] | [
{
"id": "split_0_train_904_entity",
"type": "progene_text",
"text": [
"Rap1p"
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"offsets": [
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17,
22
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],
"normalized": []
},
{
"id": "split_0_train_905_entity",
"type": "progene_text",
"text": [
"Abf1p"
],
"offsets": [
[
27,
32
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_682 | split_0_train_682 | [
{
"id": "split_0_train_682_passage",
"type": "progene_text",
"text": [
"We characterized a collection of 15 mutations that restore the alpha-mating phenotype to MATalpha HMRa - e** strains ."
],
"offsets": [
[
0,
118
]
]
}
] | [
{
"id": "split_0_train_906_entity",
"type": "progene_text",
"text": [
"MATalpha"
],
"offsets": [
[
89,
97
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_683 | split_0_train_683 | [
{
"id": "split_0_train_683_passage",
"type": "progene_text",
"text": [
"These mutations defined three complementation groups , two new groups and one group that corresponded to the previously identified SAS2 gene ."
],
"offsets": [
[
0,
142
]
]
}
] | [
{
"id": "split_0_train_907_entity",
"type": "progene_text",
"text": [
"SAS2"
],
"offsets": [
[
131,
135
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_684 | split_0_train_684 | [
{
"id": "split_0_train_684_passage",
"type": "progene_text",
"text": [
"We cloned the genes that complemented members of the new groups and identified two previously uncharacterized genes , which we named SAS4 and SAS5 ."
],
"offsets": [
[
0,
148
]
]
}
] | [
{
"id": "split_0_train_908_entity",
"type": "progene_text",
"text": [
"SAS4"
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133,
137
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},
{
"id": "split_0_train_909_entity",
"type": "progene_text",
"text": [
"SAS5"
],
"offsets": [
[
142,
146
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_685 | split_0_train_685 | [
{
"id": "split_0_train_685_passage",
"type": "progene_text",
"text": [
"Neither SAS4 nor SAS5 was required for viability ."
],
"offsets": [
[
0,
50
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]
}
] | [
{
"id": "split_0_train_910_entity",
"type": "progene_text",
"text": [
"SAS4"
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8,
12
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},
{
"id": "split_0_train_911_entity",
"type": "progene_text",
"text": [
"SAS5"
],
"offsets": [
[
17,
21
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_686 | split_0_train_686 | [
{
"id": "split_0_train_686_passage",
"type": "progene_text",
"text": [
"Null alleles of SAS4 and SAS5 restored SIR4 - dependent silencing at HMR , establishing that each is a regulator of silencing ."
],
"offsets": [
[
0,
127
]
]
}
] | [
{
"id": "split_0_train_912_entity",
"type": "progene_text",
"text": [
"SAS4"
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"offsets": [
[
16,
20
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],
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},
{
"id": "split_0_train_913_entity",
"type": "progene_text",
"text": [
"SAS5"
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"offsets": [
[
25,
29
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],
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},
{
"id": "split_0_train_914_entity",
"type": "progene_text",
"text": [
"SIR4"
],
"offsets": [
[
39,
43
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_687 | split_0_train_687 | [
{
"id": "split_0_train_687_passage",
"type": "progene_text",
"text": [
"Null alleles of SAS4 and SAS5 bypassed the role of the Abf1p binding site of the HMR-E silencer but not the role of the ACS or Rap1p binding site ."
],
"offsets": [
[
0,
147
]
]
}
] | [
{
"id": "split_0_train_915_entity",
"type": "progene_text",
"text": [
"SAS4"
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16,
20
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],
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},
{
"id": "split_0_train_916_entity",
"type": "progene_text",
"text": [
"SAS5"
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[
25,
29
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],
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},
{
"id": "split_0_train_917_entity",
"type": "progene_text",
"text": [
"Abf1p"
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55,
60
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],
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},
{
"id": "split_0_train_918_entity",
"type": "progene_text",
"text": [
"Rap1p"
],
"offsets": [
[
127,
132
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_688 | split_0_train_688 | [
{
"id": "split_0_train_688_passage",
"type": "progene_text",
"text": [
"Previous analysis indicated that SAS2 is homologous to a human gene that is a site of recurring translocations involved in acute myeloid leukemia ."
],
"offsets": [
[
0,
147
]
]
}
] | [
{
"id": "split_0_train_919_entity",
"type": "progene_text",
"text": [
"SAS2"
],
"offsets": [
[
33,
37
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_689 | split_0_train_689 | [
{
"id": "split_0_train_689_passage",
"type": "progene_text",
"text": [
"Similarly , SAS5 is a member of a gene family that included two human genes that are the sites of recurring translocations involved in acute myeloid leukemia ."
],
"offsets": [
[
0,
159
]
]
}
] | [
{
"id": "split_0_train_920_entity",
"type": "progene_text",
"text": [
"SAS5"
],
"offsets": [
[
12,
16
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_690 | split_0_train_690 | [
{
"id": "split_0_train_690_passage",
"type": "progene_text",
"text": [
"Signal joint formation is inhibited in murine scid preB cells and fibroblasts in substrates with homopolymeric coding ends ."
],
"offsets": [
[
0,
124
]
]
}
] | [] | [] | [] | [] |
split_0_train_691 | split_0_train_691 | [
{
"id": "split_0_train_691_passage",
"type": "progene_text",
"text": [
"During B and T lymphocyte development , immunoglobulin and T cell receptor genes are assembled from the germline V , ( D ) and J gene segments ( Lewis , S.M. , 1994. The mechanism of V(D) J joining : lessons from molecular , immunological and comparative analyses. Adv. Immunol. 56 , 27 - 150 ) ."
],
"offsets": [
[
0,
296
]
]
}
] | [
{
"id": "split_0_train_921_entity",
"type": "progene_text",
"text": [
"immunoglobulin"
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40,
54
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},
{
"id": "split_0_train_922_entity",
"type": "progene_text",
"text": [
"T cell receptor"
],
"offsets": [
[
59,
74
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_692 | split_0_train_692 | [
{
"id": "split_0_train_692_passage",
"type": "progene_text",
"text": [
"These DNA rearrangements , responsible for immune system diversity , are mediated by a site specific recombination machinery via recognition signal sequences ( RSSs ) composed of conserved heptamers and nonamers separated by spacers of 12 or 23 nucleotides ( Lewis , S.M. , 1994. The mechanism of V(D) J joining : lessons from molecular , immunological and comparative analyses. Adv. Immunol. 56 , 27 - 150 ) ."
],
"offsets": [
[
0,
410
]
]
}
] | [] | [] | [] | [] |
split_0_train_693 | split_0_train_693 | [
{
"id": "split_0_train_693_passage",
"type": "progene_text",
"text": [
"Recombination occurs only between a RSS with a 12mer spacer and a RSS with a 23mer spacer ( Lewis , S.M. , 1994. The mechanism of V(D)J joining : lessons from molecular , immunological and comparative analyses ."
],
"offsets": [
[
0,
211
]
]
}
] | [] | [] | [] | [] |
split_0_train_694 | split_0_train_694 | [
{
"id": "split_0_train_694_passage",
"type": "progene_text",
"text": [
"Adv ."
],
"offsets": [
[
0,
5
]
]
}
] | [] | [] | [] | [] |
split_0_train_695 | split_0_train_695 | [
{
"id": "split_0_train_695_passage",
"type": "progene_text",
"text": [
"Immunol. 56 , 27 - 150 ) ."
],
"offsets": [
[
0,
26
]
]
}
] | [] | [] | [] | [] |
split_0_train_696 | split_0_train_696 | [
{
"id": "split_0_train_696_passage",
"type": "progene_text",
"text": [
"RAG1 and RAG2 proteins cleave precisely at the RSS - coding sequence border leading to flush signal ends and coding ends with a hairpin structure ( Eastman , M. , Leu , T. , Schatz , D. , 1996 ."
],
"offsets": [
[
0,
194
]
]
}
] | [
{
"id": "split_0_train_923_entity",
"type": "progene_text",
"text": [
"RAG1"
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[
0,
4
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],
"normalized": []
},
{
"id": "split_0_train_924_entity",
"type": "progene_text",
"text": [
"RAG2"
],
"offsets": [
[
9,
13
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_697 | split_0_train_697 | [
{
"id": "split_0_train_697_passage",
"type": "progene_text",
"text": [
"Initiation of V(D)J recombination in vitro obeying the 12 / 23 rule ."
],
"offsets": [
[
0,
69
]
]
}
] | [] | [] | [] | [] |
split_0_train_698 | split_0_train_698 | [
{
"id": "split_0_train_698_passage",
"type": "progene_text",
"text": [
"Nature 380 , 85 - 88 ; Roth , D.B. , Menetski , J.P. , Nakajima , P.B. , Bosma , M.J. , Gellert , M. , 1992. V(D)J recombination : broken DNA molecules with covalently sealed ( hairpin ) coding ends in scid mouse thymocytes ."
],
"offsets": [
[
0,
225
]
]
}
] | [] | [] | [] | [] |
split_0_train_699 | split_0_train_699 | [
{
"id": "split_0_train_699_passage",
"type": "progene_text",
"text": [
"Cell 983 - 991 : Roth , D.B. , Zhu , C. , Gellert. M. , 1993 ."
],
"offsets": [
[
0,
62
]
]
}
] | [] | [] | [] | [] |