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split_0_train_700 | split_0_train_700 | [
{
"id": "split_0_train_700_passage",
"type": "progene_text",
"text": [
"Characterization of broken DNA molecules associated with V(D)J recombination ."
],
"offsets": [
[
0,
78
]
]
}
]
| []
| []
| []
| []
|
split_0_train_701 | split_0_train_701 | [
{
"id": "split_0_train_701_passage",
"type": "progene_text",
"text": [
"Proc. Natl. Acad. Sci. USA 90 , 10 , 788 - 10 , 792 ; van Gent , D. , McBlane , J. ."
],
"offsets": [
[
0,
84
]
]
}
]
| []
| []
| []
| []
|
split_0_train_702 | split_0_train_702 | [
{
"id": "split_0_train_702_passage",
"type": "progene_text",
"text": [
"Sadofsky , M. , Hesse , J. , Gellert , M. , 1995 ."
],
"offsets": [
[
0,
50
]
]
}
]
| []
| []
| []
| []
|
split_0_train_703 | split_0_train_703 | [
{
"id": "split_0_train_703_passage",
"type": "progene_text",
"text": [
"Initiation of V(D)J recombination in a cell - free system ."
],
"offsets": [
[
0,
59
]
]
}
]
| []
| []
| []
| []
|
split_0_train_704 | split_0_train_704 | [
{
"id": "split_0_train_704_passage",
"type": "progene_text",
"text": [
"Cell 81 , 925 - 934 ) ."
],
"offsets": [
[
0,
23
]
]
}
]
| []
| []
| []
| []
|
split_0_train_705 | split_0_train_705 | [
{
"id": "split_0_train_705_passage",
"type": "progene_text",
"text": [
"Signal ends join , forming a signal joint ."
],
"offsets": [
[
0,
43
]
]
}
]
| []
| []
| []
| []
|
split_0_train_706 | split_0_train_706 | [
{
"id": "split_0_train_706_passage",
"type": "progene_text",
"text": [
"The hairpin coding ends are opened by a yet unknown endonuclease , and are further processed to form the coding joint ( Lewis , S.M. , 1994 ."
],
"offsets": [
[
0,
141
]
]
}
]
| [
{
"id": "split_0_train_925_entity",
"type": "progene_text",
"text": [
"endonuclease"
],
"offsets": [
[
52,
64
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_707 | split_0_train_707 | [
{
"id": "split_0_train_707_passage",
"type": "progene_text",
"text": [
"The mechanism of V(D)J joining : lessons from molecular , immunological and comparative analyses ."
],
"offsets": [
[
0,
98
]
]
}
]
| []
| []
| []
| []
|
split_0_train_708 | split_0_train_708 | [
{
"id": "split_0_train_708_passage",
"type": "progene_text",
"text": [
"Ad ."
],
"offsets": [
[
0,
4
]
]
}
]
| []
| []
| []
| []
|
split_0_train_709 | split_0_train_709 | [
{
"id": "split_0_train_709_passage",
"type": "progene_text",
"text": [
"Immunol. 56 , 27 - 150. ) The murine scid mutation has been shown to affect coding joints , but much less signal joint formation ."
],
"offsets": [
[
0,
130
]
]
}
]
| []
| []
| []
| []
|
split_0_train_710 | split_0_train_710 | [
{
"id": "split_0_train_710_passage",
"type": "progene_text",
"text": [
"In this study we demonstrate that the murine scid mutation inhibits correct signal joint formation when both coding ends contain homopolymeric sequences ."
],
"offsets": [
[
0,
154
]
]
}
]
| []
| []
| []
| []
|
split_0_train_711 | split_0_train_711 | [
{
"id": "split_0_train_711_passage",
"type": "progene_text",
"text": [
"We suggest that this finding may be due to the function of the SCID protein as an assembly component in V(D)J recombination ."
],
"offsets": [
[
0,
125
]
]
}
]
| []
| []
| []
| []
|
split_0_train_712 | split_0_train_712 | [
{
"id": "split_0_train_712_passage",
"type": "progene_text",
"text": [
"The 193 - kD vault protein , VPARP , is a novel poly(ADP-ribose ) polymerase ."
],
"offsets": [
[
0,
78
]
]
}
]
| [
{
"id": "split_0_train_926_entity",
"type": "progene_text",
"text": [
"193 - kD vault protein"
],
"offsets": [
[
4,
26
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{
"id": "split_0_train_927_entity",
"type": "progene_text",
"text": [
"VPARP"
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"offsets": [
[
29,
34
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"normalized": []
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{
"id": "split_0_train_928_entity",
"type": "progene_text",
"text": [
"poly(ADP-ribose ) polymerase"
],
"offsets": [
[
48,
76
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_713 | split_0_train_713 | [
{
"id": "split_0_train_713_passage",
"type": "progene_text",
"text": [
"Mammalian vaults are ribonucleoprotein ( RNP ) complexes , composed of a small ribonucleic acid and three proteins of 100 , 193 , and 240 kD in size ."
],
"offsets": [
[
0,
150
]
]
}
]
| []
| []
| []
| []
|
split_0_train_714 | split_0_train_714 | [
{
"id": "split_0_train_714_passage",
"type": "progene_text",
"text": [
"The 100 - kD major vault protein ( MVP ) accounts for > 70 % of the particle mass ."
],
"offsets": [
[
0,
83
]
]
}
]
| [
{
"id": "split_0_train_929_entity",
"type": "progene_text",
"text": [
"major vault protein"
],
"offsets": [
[
13,
32
]
],
"normalized": []
},
{
"id": "split_0_train_930_entity",
"type": "progene_text",
"text": [
"MVP"
],
"offsets": [
[
35,
38
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_715 | split_0_train_715 | [
{
"id": "split_0_train_715_passage",
"type": "progene_text",
"text": [
"We have identified the 193 - kD vault protein by its interaction with the MVP in a yeast two - hybrid screen and confirmed its identity by peptide sequence analysis ."
],
"offsets": [
[
0,
166
]
]
}
]
| [
{
"id": "split_0_train_931_entity",
"type": "progene_text",
"text": [
"193 - kD vault protein"
],
"offsets": [
[
23,
45
]
],
"normalized": []
},
{
"id": "split_0_train_932_entity",
"type": "progene_text",
"text": [
"MVP"
],
"offsets": [
[
74,
77
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_716 | split_0_train_716 | [
{
"id": "split_0_train_716_passage",
"type": "progene_text",
"text": [
"Analysis of the protein sequence revealed a region of approximately 350 amino acids that shares 28 % identity with the catalytic domain of poly(ADP-ribose ) polymerase ( PARP ) ."
],
"offsets": [
[
0,
178
]
]
}
]
| [
{
"id": "split_0_train_933_entity",
"type": "progene_text",
"text": [
"poly(ADP-ribose ) polymerase"
],
"offsets": [
[
139,
167
]
],
"normalized": []
},
{
"id": "split_0_train_934_entity",
"type": "progene_text",
"text": [
"PARP"
],
"offsets": [
[
170,
174
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_717 | split_0_train_717 | [
{
"id": "split_0_train_717_passage",
"type": "progene_text",
"text": [
"PARP is a nuclear protein that catalyzes the formation of ADP-ribose polymers in response to DNA damage ."
],
"offsets": [
[
0,
105
]
]
}
]
| [
{
"id": "split_0_train_935_entity",
"type": "progene_text",
"text": [
"PARP"
],
"offsets": [
[
0,
4
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_718 | split_0_train_718 | [
{
"id": "split_0_train_718_passage",
"type": "progene_text",
"text": [
"The catalytic domain of p193 was expressed and purified from bacterial extracts ."
],
"offsets": [
[
0,
81
]
]
}
]
| [
{
"id": "split_0_train_936_entity",
"type": "progene_text",
"text": [
"p193"
],
"offsets": [
[
24,
28
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_719 | split_0_train_719 | [
{
"id": "split_0_train_719_passage",
"type": "progene_text",
"text": [
"Like PARP , this domain is capable of catalyzing a poly(ADP-ribosyl ) ation reaction ; thus , the 193 - kD protein is a new PARP ."
],
"offsets": [
[
0,
130
]
]
}
]
| [
{
"id": "split_0_train_937_entity",
"type": "progene_text",
"text": [
"PARP"
],
"offsets": [
[
5,
9
]
],
"normalized": []
},
{
"id": "split_0_train_938_entity",
"type": "progene_text",
"text": [
"PARP"
],
"offsets": [
[
124,
128
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_720 | split_0_train_720 | [
{
"id": "split_0_train_720_passage",
"type": "progene_text",
"text": [
"Purified vaults also contain the poly(ADP-ribosyl ) ation activity , indicating that the assembled particle retains enzymatic activity ."
],
"offsets": [
[
0,
136
]
]
}
]
| []
| []
| []
| []
|
split_0_train_721 | split_0_train_721 | [
{
"id": "split_0_train_721_passage",
"type": "progene_text",
"text": [
"Furthermore , we show that one substrate for this vault - associated PARP activity is the MVP ."
],
"offsets": [
[
0,
95
]
]
}
]
| [
{
"id": "split_0_train_939_entity",
"type": "progene_text",
"text": [
"PARP"
],
"offsets": [
[
69,
73
]
],
"normalized": []
},
{
"id": "split_0_train_940_entity",
"type": "progene_text",
"text": [
"MVP"
],
"offsets": [
[
90,
93
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_722 | split_0_train_722 | [
{
"id": "split_0_train_722_passage",
"type": "progene_text",
"text": [
"Immunofluorescence and biochemical data reveal that p193 protein is not entirely associated with the vault particle , suggesting that it may interact with other protein(s) ."
],
"offsets": [
[
0,
173
]
]
}
]
| [
{
"id": "split_0_train_941_entity",
"type": "progene_text",
"text": [
"p193"
],
"offsets": [
[
52,
56
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_723 | split_0_train_723 | [
{
"id": "split_0_train_723_passage",
"type": "progene_text",
"text": [
"A portion of p193 is nuclear and localizes to the mitotic spindle ."
],
"offsets": [
[
0,
67
]
]
}
]
| [
{
"id": "split_0_train_942_entity",
"type": "progene_text",
"text": [
"p193"
],
"offsets": [
[
13,
17
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_724 | split_0_train_724 | [
{
"id": "split_0_train_724_passage",
"type": "progene_text",
"text": [
"Characterization of the targeting , binding , and phosphorylation site domains of an A kinase anchor protein and a myristoylated alanine - rich C kinase substrate - like analog that are encoded by a single gene ."
],
"offsets": [
[
0,
212
]
]
}
]
| [
{
"id": "split_0_train_943_entity",
"type": "progene_text",
"text": [
"A kinase anchor protein"
],
"offsets": [
[
85,
108
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],
"normalized": []
},
{
"id": "split_0_train_944_entity",
"type": "progene_text",
"text": [
"myristoylated alanine - rich C kinase substrate"
],
"offsets": [
[
115,
162
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_725 | split_0_train_725 | [
{
"id": "split_0_train_725_passage",
"type": "progene_text",
"text": [
"A novel Drosophila A kinase anchor protein , Drosophila A kinase anchor protein 200 ( DAKAP200 ) , is predicted to be involved in routing , mediating , and integrating signals carried by cAMP , Ca(2+) , and diacylglycerol ( Li , Z. , Rossi , E. A. , Hoheisel , J. D. , Kalderon , D. , and Rubin , C. S. ( 1999 ) J. Biol. Chem. 274 , 27191 - 27200 ) ."
],
"offsets": [
[
0,
350
]
]
}
]
| [
{
"id": "split_0_train_945_entity",
"type": "progene_text",
"text": [
"A kinase anchor protein"
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"offsets": [
[
19,
42
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"normalized": []
},
{
"id": "split_0_train_946_entity",
"type": "progene_text",
"text": [
"A kinase anchor protein 200"
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"offsets": [
[
56,
83
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"normalized": []
},
{
"id": "split_0_train_947_entity",
"type": "progene_text",
"text": [
"DAKAP200"
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"offsets": [
[
86,
94
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_726 | split_0_train_726 | [
{
"id": "split_0_train_726_passage",
"type": "progene_text",
"text": [
"Experiments designed to assess this hypothesis now (a) establish the function , boundaries and identity of critical amino acids of the protein kinase AII ( PKAII ) tethering site of DAKAP200 ; (b) demonstrate that residues 119 - 148 mediate binding with Ca(2+) - calmodulin and F-actin ; (c) show that a polybasic region of DAKAP200 is a substrate for protein kinase C ; (d) reveal that phosphorylation of the polybasic domain regulates affinity for F-actin and Ca(2+) - calmodulin ; and (e) indicate that DAKAP200 is myristoylated and that this modification promotes targeting of DAKAP200 to plasma membrane ."
],
"offsets": [
[
0,
610
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]
}
]
| [
{
"id": "split_0_train_948_entity",
"type": "progene_text",
"text": [
"protein kinase AII"
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135,
153
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{
"id": "split_0_train_949_entity",
"type": "progene_text",
"text": [
"PKAII"
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"offsets": [
[
156,
161
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"normalized": []
},
{
"id": "split_0_train_950_entity",
"type": "progene_text",
"text": [
"DAKAP200"
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"offsets": [
[
182,
190
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"normalized": []
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{
"id": "split_0_train_951_entity",
"type": "progene_text",
"text": [
"calmodulin"
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263,
273
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{
"id": "split_0_train_952_entity",
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"text": [
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278,
285
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{
"id": "split_0_train_953_entity",
"type": "progene_text",
"text": [
"DAKAP200"
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[
324,
332
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"normalized": []
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{
"id": "split_0_train_954_entity",
"type": "progene_text",
"text": [
"protein kinase C"
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352,
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"normalized": []
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{
"id": "split_0_train_955_entity",
"type": "progene_text",
"text": [
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450,
457
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{
"id": "split_0_train_956_entity",
"type": "progene_text",
"text": [
"calmodulin"
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[
471,
481
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{
"id": "split_0_train_957_entity",
"type": "progene_text",
"text": [
"DAKAP200"
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506,
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{
"id": "split_0_train_958_entity",
"type": "progene_text",
"text": [
"DAKAP200"
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"offsets": [
[
581,
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"normalized": []
}
]
| []
| []
| []
|
split_0_train_727 | split_0_train_727 | [
{
"id": "split_0_train_727_passage",
"type": "progene_text",
"text": [
"DeltaDAKAP200 , a second product of the DAKAP200 gene , cannot tether PKAII ."
],
"offsets": [
[
0,
77
]
]
}
]
| [
{
"id": "split_0_train_959_entity",
"type": "progene_text",
"text": [
"DeltaDAKAP200"
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"offsets": [
[
0,
13
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},
{
"id": "split_0_train_960_entity",
"type": "progene_text",
"text": [
"DAKAP200"
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"offsets": [
[
40,
48
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"normalized": []
},
{
"id": "split_0_train_961_entity",
"type": "progene_text",
"text": [
"PKAII"
],
"offsets": [
[
70,
75
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_728 | split_0_train_728 | [
{
"id": "split_0_train_728_passage",
"type": "progene_text",
"text": [
"However , DeltaDAKAP200 is myristoylated and contains a phosphorylation site domain that binds Ca(2+) - calmodulin and F-actin ."
],
"offsets": [
[
0,
128
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]
}
]
| [
{
"id": "split_0_train_962_entity",
"type": "progene_text",
"text": [
"DeltaDAKAP200"
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10,
23
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{
"id": "split_0_train_963_entity",
"type": "progene_text",
"text": [
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104,
114
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{
"id": "split_0_train_964_entity",
"type": "progene_text",
"text": [
"F-actin"
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"offsets": [
[
119,
126
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"normalized": []
}
]
| []
| []
| []
|
split_0_train_729 | split_0_train_729 | [
{
"id": "split_0_train_729_passage",
"type": "progene_text",
"text": [
"An atypical amino acid composition , a high level of negative charge , exceptional thermostability , unusual hydrodynamic properties , properties of the phosphorylation site domain , and a calculated M(r) of 38,000 suggest that DeltaDAKAP200 is a new member of the myristoylated alanine - rich C kinase substrate protein family ."
],
"offsets": [
[
0,
329
]
]
}
]
| [
{
"id": "split_0_train_965_entity",
"type": "progene_text",
"text": [
"DeltaDAKAP200"
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"offsets": [
[
228,
241
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{
"id": "split_0_train_966_entity",
"type": "progene_text",
"text": [
"myristoylated alanine - rich C kinase substrate protein family"
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"offsets": [
[
265,
327
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_730 | split_0_train_730 | [
{
"id": "split_0_train_730_passage",
"type": "progene_text",
"text": [
"DAKAP200 is a potentially mobile , chimeric A kinase anchor protein - myristoylated alanine - rich C kinase substrate protein that may facilitate localized reception and targeted transmission of signals carried by cAMP , Ca(2+) , and diacylglycerol ."
],
"offsets": [
[
0,
250
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]
| [
{
"id": "split_0_train_967_entity",
"type": "progene_text",
"text": [
"DAKAP200"
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{
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"A kinase anchor protein"
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44,
67
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"type": "progene_text",
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_731 | split_0_train_731 | [
{
"id": "split_0_train_731_passage",
"type": "progene_text",
"text": [
"Natural Haemophilus influenzae type b capsular polysaccharide antibodies in 412 infants and children from West Africa ( Burkina - Faso ) and France : a cross - sectional serosurvey ."
],
"offsets": [
[
0,
182
]
]
}
]
| []
| []
| []
| []
|
split_0_train_732 | split_0_train_732 | [
{
"id": "split_0_train_732_passage",
"type": "progene_text",
"text": [
"Prior to possible introduction of large - scale vaccination programmes , an estimation and comparison of naturally acquired immunity against Haemophilus influenzae type b ( Hib ) was carried out in two populations of age-stratified infants and children ( from birth to 14 years old ) in Burkina - Faso ( West Africa ) ( n = 206 ) and France ( n = 206 ) ."
],
"offsets": [
[
0,
354
]
]
}
]
| []
| []
| []
| []
|
split_0_train_733 | split_0_train_733 | [
{
"id": "split_0_train_733_passage",
"type": "progene_text",
"text": [
"Hib capsular polysaccharide antibodies were detected by an ELISA method ."
],
"offsets": [
[
0,
73
]
]
}
]
| []
| []
| []
| []
|
split_0_train_734 | split_0_train_734 | [
{
"id": "split_0_train_734_passage",
"type": "progene_text",
"text": [
"The difference in the percentages of minimum protective levels for the two populations were not significant ( 0.15 microg / ml ) for newborns ( 0 - 1 month ) but became significant as early as 2 to 3 months of age ( p < 0.01 ) when lower levels were found among infants from Burkina - Faso ."
],
"offsets": [
[
0,
291
]
]
}
]
| []
| []
| []
| []
|
split_0_train_735 | split_0_train_735 | [
{
"id": "split_0_train_735_passage",
"type": "progene_text",
"text": [
"Subsequently , the percentages in both countries remained low until 11 months of age and showed no significant differences ."
],
"offsets": [
[
0,
124
]
]
}
]
| []
| []
| []
| []
|
split_0_train_736 | split_0_train_736 | [
{
"id": "split_0_train_736_passage",
"type": "progene_text",
"text": [
"For children between 12 and 35 months , the results > or = 0.15 microg / ml were significantly higher in France ( p < or = 0.05 ) ."
],
"offsets": [
[
0,
131
]
]
}
]
| []
| []
| []
| []
|
split_0_train_737 | split_0_train_737 | [
{
"id": "split_0_train_737_passage",
"type": "progene_text",
"text": [
"From 36 months , the percentage of minimum seropositivity increased in Burkina - Faso , so that the difference was no longer significant ."
],
"offsets": [
[
0,
138
]
]
}
]
| []
| []
| []
| []
|
split_0_train_738 | split_0_train_738 | [
{
"id": "split_0_train_738_passage",
"type": "progene_text",
"text": [
"In each country , the percentage of children with the minimum protective level varied significantly ( p < or = 0.05 ) according to age ( 0 - 47 months ) ."
],
"offsets": [
[
0,
154
]
]
}
]
| []
| []
| []
| []
|
split_0_train_739 | split_0_train_739 | [
{
"id": "split_0_train_739_passage",
"type": "progene_text",
"text": [
"None of the children from Burkina - Faso or France had antibody levels > 1.0 microg / ml before one year of age ."
],
"offsets": [
[
0,
113
]
]
}
]
| []
| []
| []
| []
|
split_0_train_740 | split_0_train_740 | [
{
"id": "split_0_train_740_passage",
"type": "progene_text",
"text": [
"Thereafter , only 9.51 % of French children in the 12 - to 17 - month age stratum and 19.2 % over 4 years of age had antibody levels > 1.0 microg / ml ."
],
"offsets": [
[
0,
152
]
]
}
]
| []
| []
| []
| []
|
split_0_train_741 | split_0_train_741 | [
{
"id": "split_0_train_741_passage",
"type": "progene_text",
"text": [
"There were no non - detectable results for children over 4 years of age , and the means for natural detectable Hib CP antibodies were > 0.15 microg / ml for both populations ."
],
"offsets": [
[
0,
175
]
]
}
]
| []
| []
| []
| []
|
split_0_train_742 | split_0_train_742 | [
{
"id": "split_0_train_742_passage",
"type": "progene_text",
"text": [
"Hib invasive infections depend on climate , socioeconomic status and ethnic and genetic factors ."
],
"offsets": [
[
0,
97
]
]
}
]
| []
| []
| []
| []
|
split_0_train_743 | split_0_train_743 | [
{
"id": "split_0_train_743_passage",
"type": "progene_text",
"text": [
"In Burkina - Faso , the large number of infants and children under 4 years of age susceptible to Hib infections suggests that large scale vaccination programmes are needed soon after birth ."
],
"offsets": [
[
0,
190
]
]
}
]
| []
| []
| []
| []
|
split_0_train_744 | split_0_train_744 | [
{
"id": "split_0_train_744_passage",
"type": "progene_text",
"text": [
"However , it would first be necessary to evaluate such factors as the frequency of Hib diseases in this population ."
],
"offsets": [
[
0,
116
]
]
}
]
| []
| []
| []
| []
|
split_0_train_745 | split_0_train_745 | [
{
"id": "split_0_train_745_passage",
"type": "progene_text",
"text": [
"MEF-2 function is modified by a novel co - repressor , MITR ."
],
"offsets": [
[
0,
61
]
]
}
]
| [
{
"id": "split_0_train_970_entity",
"type": "progene_text",
"text": [
"MEF-2"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "split_0_train_971_entity",
"type": "progene_text",
"text": [
"MITR"
],
"offsets": [
[
55,
59
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_746 | split_0_train_746 | [
{
"id": "split_0_train_746_passage",
"type": "progene_text",
"text": [
"The MEF-2 proteins are a family of transcriptional activators that have been detected in a wide variety of cell types ."
],
"offsets": [
[
0,
119
]
]
}
]
| [
{
"id": "split_0_train_972_entity",
"type": "progene_text",
"text": [
"MEF-2"
],
"offsets": [
[
4,
9
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_747 | split_0_train_747 | [
{
"id": "split_0_train_747_passage",
"type": "progene_text",
"text": [
"In skeletal muscle cells , MEF-2 proteins interact with members of the MyoD family of transcriptional activators to synergistically activate gene expression ."
],
"offsets": [
[
0,
158
]
]
}
]
| [
{
"id": "split_0_train_973_entity",
"type": "progene_text",
"text": [
"MEF-2"
],
"offsets": [
[
27,
32
]
],
"normalized": []
},
{
"id": "split_0_train_974_entity",
"type": "progene_text",
"text": [
"MyoD family"
],
"offsets": [
[
71,
82
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_748 | split_0_train_748 | [
{
"id": "split_0_train_748_passage",
"type": "progene_text",
"text": [
"Similar interactions with tissue or lineage - specific cofactors may also underlie MEF-2 function in other cell types ."
],
"offsets": [
[
0,
119
]
]
}
]
| [
{
"id": "split_0_train_975_entity",
"type": "progene_text",
"text": [
"MEF-2"
],
"offsets": [
[
83,
88
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_749 | split_0_train_749 | [
{
"id": "split_0_train_749_passage",
"type": "progene_text",
"text": [
"In order to screen for such cofactors , we have used a transcriptionally inactive mutant of Xenopus MEF2D in a yeast two - hybrid screen ."
],
"offsets": [
[
0,
138
]
]
}
]
| [
{
"id": "split_0_train_976_entity",
"type": "progene_text",
"text": [
"MEF2D"
],
"offsets": [
[
100,
105
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_750 | split_0_train_750 | [
{
"id": "split_0_train_750_passage",
"type": "progene_text",
"text": [
"This approach has identified a novel protein expressed in the early embryo that binds to XMEF2D and XMEF2A ."
],
"offsets": [
[
0,
108
]
]
}
]
| [
{
"id": "split_0_train_977_entity",
"type": "progene_text",
"text": [
"XMEF2D"
],
"offsets": [
[
89,
95
]
],
"normalized": []
},
{
"id": "split_0_train_978_entity",
"type": "progene_text",
"text": [
"XMEF2A"
],
"offsets": [
[
100,
106
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_751 | split_0_train_751 | [
{
"id": "split_0_train_751_passage",
"type": "progene_text",
"text": [
"The MEF-2 interacting transcription repressor ( MITR ) protein binds to the N - terminal MADS / MEF-2 region of the MEF-2 proteins but does not bind to the related Xenopus MADS protein serum response factor ."
],
"offsets": [
[
0,
208
]
]
}
]
| [
{
"id": "split_0_train_979_entity",
"type": "progene_text",
"text": [
"MEF-2 interacting transcription repressor"
],
"offsets": [
[
4,
45
]
],
"normalized": []
},
{
"id": "split_0_train_980_entity",
"type": "progene_text",
"text": [
"MITR"
],
"offsets": [
[
48,
52
]
],
"normalized": []
},
{
"id": "split_0_train_981_entity",
"type": "progene_text",
"text": [
"MADS"
],
"offsets": [
[
89,
93
]
],
"normalized": []
},
{
"id": "split_0_train_982_entity",
"type": "progene_text",
"text": [
"MEF-2"
],
"offsets": [
[
96,
101
]
],
"normalized": []
},
{
"id": "split_0_train_983_entity",
"type": "progene_text",
"text": [
"MEF-2"
],
"offsets": [
[
116,
121
]
],
"normalized": []
},
{
"id": "split_0_train_984_entity",
"type": "progene_text",
"text": [
"MADS"
],
"offsets": [
[
172,
176
]
],
"normalized": []
},
{
"id": "split_0_train_985_entity",
"type": "progene_text",
"text": [
"serum response factor"
],
"offsets": [
[
185,
206
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_752 | split_0_train_752 | [
{
"id": "split_0_train_752_passage",
"type": "progene_text",
"text": [
"In the early embryo , MITR expression commences at the neurula stage within the mature somites and is subsequently restricted to the myotomal muscle ."
],
"offsets": [
[
0,
150
]
]
}
]
| [
{
"id": "split_0_train_986_entity",
"type": "progene_text",
"text": [
"MITR"
],
"offsets": [
[
22,
26
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_753 | split_0_train_753 | [
{
"id": "split_0_train_753_passage",
"type": "progene_text",
"text": [
"In functional assays , MITR negatively regulates MEF-2 - dependent transcription and we show that this repression is mediated by direct binding of MITR to the histone deacetylase HDAC1 ."
],
"offsets": [
[
0,
186
]
]
}
]
| [
{
"id": "split_0_train_987_entity",
"type": "progene_text",
"text": [
"MITR"
],
"offsets": [
[
23,
27
]
],
"normalized": []
},
{
"id": "split_0_train_988_entity",
"type": "progene_text",
"text": [
"MEF-2"
],
"offsets": [
[
49,
54
]
],
"normalized": []
},
{
"id": "split_0_train_989_entity",
"type": "progene_text",
"text": [
"MITR"
],
"offsets": [
[
147,
151
]
],
"normalized": []
},
{
"id": "split_0_train_990_entity",
"type": "progene_text",
"text": [
"histone deacetylase"
],
"offsets": [
[
159,
178
]
],
"normalized": []
},
{
"id": "split_0_train_991_entity",
"type": "progene_text",
"text": [
"HDAC1"
],
"offsets": [
[
179,
184
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_754 | split_0_train_754 | [
{
"id": "split_0_train_754_passage",
"type": "progene_text",
"text": [
"Thus , we propose that MITR acts as a co - repressor , recruiting a specific deacetylase to downregulate MEF-2 activity ."
],
"offsets": [
[
0,
121
]
]
}
]
| [
{
"id": "split_0_train_992_entity",
"type": "progene_text",
"text": [
"MITR"
],
"offsets": [
[
23,
27
]
],
"normalized": []
},
{
"id": "split_0_train_993_entity",
"type": "progene_text",
"text": [
"deacetylase"
],
"offsets": [
[
77,
88
]
],
"normalized": []
},
{
"id": "split_0_train_994_entity",
"type": "progene_text",
"text": [
"MEF-2"
],
"offsets": [
[
105,
110
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_755 | split_0_train_755 | [
{
"id": "split_0_train_755_passage",
"type": "progene_text",
"text": [
"Electromyographic differentiation of diplegic cerebral palsy from idiopathic toe walking : involuntary coactivation of the quadriceps and gastrocnemius ."
],
"offsets": [
[
0,
153
]
]
}
]
| []
| []
| []
| []
|
split_0_train_756 | split_0_train_756 | [
{
"id": "split_0_train_756_passage",
"type": "progene_text",
"text": [
"Clinical differentiation of patients with mild diplegic cerebral palsy ( CP ) and idiopathic toe walking ( ITW ) can be difficult ."
],
"offsets": [
[
0,
131
]
]
}
]
| []
| []
| []
| []
|
split_0_train_757 | split_0_train_757 | [
{
"id": "split_0_train_757_passage",
"type": "progene_text",
"text": [
"However , an involuntary extensor pattern may be a distinguishing sign ."
],
"offsets": [
[
0,
72
]
]
}
]
| []
| []
| []
| []
|
split_0_train_758 | split_0_train_758 | [
{
"id": "split_0_train_758_passage",
"type": "progene_text",
"text": [
"The purpose of this study was to determine if selected gait parameters or patterns of electromyogram ( EMG ) timing of quadriceps , gastrocnemius , and tibialis anterior during knee extension while sitting can distinguish between these patients ."
],
"offsets": [
[
0,
246
]
]
}
]
| []
| []
| []
| []
|
split_0_train_759 | split_0_train_759 | [
{
"id": "split_0_train_759_passage",
"type": "progene_text",
"text": [
"The hypothesis was that EMG testing for selective control of the quadriceps and gastrocnemius could differentiate patients with diplegic CP from normal controls and from patients with ITW ."
],
"offsets": [
[
0,
189
]
]
}
]
| []
| []
| []
| []
|
split_0_train_760 | split_0_train_760 | [
{
"id": "split_0_train_760_passage",
"type": "progene_text",
"text": [
"We evaluated 10 control , eight CP , and eight ITW subjects ."
],
"offsets": [
[
0,
61
]
]
}
]
| []
| []
| []
| []
|
split_0_train_761 | split_0_train_761 | [
{
"id": "split_0_train_761_passage",
"type": "progene_text",
"text": [
"Measurements included walking speed , energy expenditure index ( EEI ) , ankle position during stance , and EMG of the quadriceps , gastrocnemius , and tibialis anterior during gait and during knee extension while sitting ."
],
"offsets": [
[
0,
223
]
]
}
]
| []
| []
| []
| []
|
split_0_train_762 | split_0_train_762 | [
{
"id": "split_0_train_762_passage",
"type": "progene_text",
"text": [
"Dynamic EMG timing during gait showed significant differences in the mean onset of the gastrocnemius between subjects with CP and ITW , but there was considerable overlap ."
],
"offsets": [
[
0,
172
]
]
}
]
| []
| []
| []
| []
|
split_0_train_763 | split_0_train_763 | [
{
"id": "split_0_train_763_passage",
"type": "progene_text",
"text": [
"More consistent differences were found during active and active - resisted knee extension while sitting ."
],
"offsets": [
[
0,
105
]
]
}
]
| []
| []
| []
| []
|
split_0_train_764 | split_0_train_764 | [
{
"id": "split_0_train_764_passage",
"type": "progene_text",
"text": [
"Mean values for gastrocnemius EMG timing recorded as a percentage of duration of quadriceps EMG while sitting were 0 and 0.4 % for controls , 0 and 3.9 % for ITW subjects , and 84.3 % and 93.4 % for CP subjects ."
],
"offsets": [
[
0,
212
]
]
}
]
| []
| []
| []
| []
|
split_0_train_765 | split_0_train_765 | [
{
"id": "split_0_train_765_passage",
"type": "progene_text",
"text": [
"Patterns of EMG timing of the quadriceps and gastrocnemius during knee extension while sitting can help to differentiate patients with mild diplegic CP from those with ITW ."
],
"offsets": [
[
0,
173
]
]
}
]
| []
| []
| []
| []
|
split_0_train_766 | split_0_train_766 | [
{
"id": "split_0_train_766_passage",
"type": "progene_text",
"text": [
"Protein kinase A-Ialpha subunit - directed antisense inhibition of ovarian cancer cell growth : crosstalk with tyrosine kinase signaling pathway ."
],
"offsets": [
[
0,
146
]
]
}
]
| [
{
"id": "split_0_train_995_entity",
"type": "progene_text",
"text": [
"Protein kinase A-Ialpha"
],
"offsets": [
[
0,
23
]
],
"normalized": []
},
{
"id": "split_0_train_996_entity",
"type": "progene_text",
"text": [
"tyrosine kinase"
],
"offsets": [
[
111,
126
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_767 | split_0_train_767 | [
{
"id": "split_0_train_767_passage",
"type": "progene_text",
"text": [
"Expression of the RIalpha subunit of cAMP - dependent protein kinase type I is increased in human cancers in which an autocrine pathway for epidermal growth factor - related growth factors is activated ."
],
"offsets": [
[
0,
203
]
]
}
]
| [
{
"id": "split_0_train_997_entity",
"type": "progene_text",
"text": [
"RIalpha subunit of cAMP - dependent protein kinase type I"
],
"offsets": [
[
18,
75
]
],
"normalized": []
},
{
"id": "split_0_train_998_entity",
"type": "progene_text",
"text": [
"epidermal growth factor"
],
"offsets": [
[
140,
163
]
],
"normalized": []
},
{
"id": "split_0_train_999_entity",
"type": "progene_text",
"text": [
"growth factors"
],
"offsets": [
[
174,
188
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_768 | split_0_train_768 | [
{
"id": "split_0_train_768_passage",
"type": "progene_text",
"text": [
"We have investigated the effect of sequence - specific inhibition of RIalpha gene expression on ovarian cancer cell growth ."
],
"offsets": [
[
0,
124
]
]
}
]
| [
{
"id": "split_0_train_1000_entity",
"type": "progene_text",
"text": [
"RIalpha"
],
"offsets": [
[
69,
76
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_769 | split_0_train_769 | [
{
"id": "split_0_train_769_passage",
"type": "progene_text",
"text": [
"We report that RIalpha antisense treatment results in a reduction in RIalpha expression and protein kinase A type I , and inhibition of cell growth ."
],
"offsets": [
[
0,
149
]
]
}
]
| [
{
"id": "split_0_train_1001_entity",
"type": "progene_text",
"text": [
"RIalpha"
],
"offsets": [
[
15,
22
]
],
"normalized": []
},
{
"id": "split_0_train_1002_entity",
"type": "progene_text",
"text": [
"RIalpha"
],
"offsets": [
[
69,
76
]
],
"normalized": []
},
{
"id": "split_0_train_1003_entity",
"type": "progene_text",
"text": [
"protein kinase A type I"
],
"offsets": [
[
92,
115
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_770 | split_0_train_770 | [
{
"id": "split_0_train_770_passage",
"type": "progene_text",
"text": [
"The growth inhibition was accompanied by changes in cell morphology and appearance of apoptotic nuclei ."
],
"offsets": [
[
0,
104
]
]
}
]
| []
| []
| []
| []
|
split_0_train_771 | split_0_train_771 | [
{
"id": "split_0_train_771_passage",
"type": "progene_text",
"text": [
"In addition , EGF receptor , c-erbB-2 and c-erbB-3 levels were reduced , and the basal and EGF - stimulated mitogen - activated protein kinase activities were reduced ."
],
"offsets": [
[
0,
168
]
]
}
]
| [
{
"id": "split_0_train_1004_entity",
"type": "progene_text",
"text": [
"EGF receptor"
],
"offsets": [
[
14,
26
]
],
"normalized": []
},
{
"id": "split_0_train_1005_entity",
"type": "progene_text",
"text": [
"c-erbB-2"
],
"offsets": [
[
29,
37
]
],
"normalized": []
},
{
"id": "split_0_train_1006_entity",
"type": "progene_text",
"text": [
"c-erbB-3"
],
"offsets": [
[
42,
50
]
],
"normalized": []
},
{
"id": "split_0_train_1007_entity",
"type": "progene_text",
"text": [
"EGF"
],
"offsets": [
[
91,
94
]
],
"normalized": []
},
{
"id": "split_0_train_1008_entity",
"type": "progene_text",
"text": [
"mitogen - activated protein kinase"
],
"offsets": [
[
108,
142
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_772 | split_0_train_772 | [
{
"id": "split_0_train_772_passage",
"type": "progene_text",
"text": [
"Protein kinase A type I and EGF receptor levels were also reduced in cells overexpressing EGF receptor antisense cDNA ."
],
"offsets": [
[
0,
119
]
]
}
]
| [
{
"id": "split_0_train_1009_entity",
"type": "progene_text",
"text": [
"Protein kinase A type I"
],
"offsets": [
[
0,
23
]
],
"normalized": []
},
{
"id": "split_0_train_1010_entity",
"type": "progene_text",
"text": [
"EGF receptor"
],
"offsets": [
[
28,
40
]
],
"normalized": []
},
{
"id": "split_0_train_1011_entity",
"type": "progene_text",
"text": [
"EGF receptor"
],
"offsets": [
[
90,
102
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_773 | split_0_train_773 | [
{
"id": "split_0_train_773_passage",
"type": "progene_text",
"text": [
"These results suggest that the antisense depletion of RIalpha leads to blockade of both the serine - threonine kinase and the tyrosine kinase signaling pathways resulting in arrest of ovarian cancer cell growth ."
],
"offsets": [
[
0,
212
]
]
}
]
| [
{
"id": "split_0_train_1012_entity",
"type": "progene_text",
"text": [
"RIalpha"
],
"offsets": [
[
54,
61
]
],
"normalized": []
},
{
"id": "split_0_train_1013_entity",
"type": "progene_text",
"text": [
"serine - threonine kinase"
],
"offsets": [
[
92,
117
]
],
"normalized": []
},
{
"id": "split_0_train_1014_entity",
"type": "progene_text",
"text": [
"tyrosine kinase"
],
"offsets": [
[
126,
141
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_774 | split_0_train_774 | [
{
"id": "split_0_train_774_passage",
"type": "progene_text",
"text": [
"Homology modeling and active - site residues probing of the thermophilic Alicyclobacillus acidocaldarius esterase 2 ."
],
"offsets": [
[
0,
117
]
]
}
]
| [
{
"id": "split_0_train_1015_entity",
"type": "progene_text",
"text": [
"esterase 2"
],
"offsets": [
[
105,
115
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_775 | split_0_train_775 | [
{
"id": "split_0_train_775_passage",
"type": "progene_text",
"text": [
"The moderate thermophilic eubacterium Alicyclobacillus ( formerly Bacillus ) acidocaldarius expresses a thermostable carboxylesterase ( esterase 2 ) belonging to the hormone - sensitive lipase ( HSL ) - like group of the esterase / lipase family ."
],
"offsets": [
[
0,
247
]
]
}
]
| [
{
"id": "split_0_train_1016_entity",
"type": "progene_text",
"text": [
"carboxylesterase"
],
"offsets": [
[
117,
133
]
],
"normalized": []
},
{
"id": "split_0_train_1017_entity",
"type": "progene_text",
"text": [
"esterase 2"
],
"offsets": [
[
136,
146
]
],
"normalized": []
},
{
"id": "split_0_train_1018_entity",
"type": "progene_text",
"text": [
"hormone - sensitive lipase"
],
"offsets": [
[
166,
192
]
],
"normalized": []
},
{
"id": "split_0_train_1019_entity",
"type": "progene_text",
"text": [
"HSL"
],
"offsets": [
[
195,
198
]
],
"normalized": []
},
{
"id": "split_0_train_1020_entity",
"type": "progene_text",
"text": [
"esterase / lipase family"
],
"offsets": [
[
221,
245
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_776 | split_0_train_776 | [
{
"id": "split_0_train_776_passage",
"type": "progene_text",
"text": [
"Based on secondary structures predictions and a secondary structure - driven multiple sequence alignment with remote homologous protein of known three - dimensional ( 3D ) structure , we previously hypothesized for this enzyme the alpha / beta-hydrolase fold typical of several lipases and esterases and identified Ser155 , Asp252 , and His282 as the putative members of the catalytic triad ."
],
"offsets": [
[
0,
392
]
]
}
]
| [
{
"id": "split_0_train_1021_entity",
"type": "progene_text",
"text": [
"alpha / beta-hydrolase"
],
"offsets": [
[
231,
253
]
],
"normalized": []
},
{
"id": "split_0_train_1022_entity",
"type": "progene_text",
"text": [
"lipases"
],
"offsets": [
[
278,
285
]
],
"normalized": []
},
{
"id": "split_0_train_1023_entity",
"type": "progene_text",
"text": [
"esterases"
],
"offsets": [
[
290,
299
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_777 | split_0_train_777 | [
{
"id": "split_0_train_777_passage",
"type": "progene_text",
"text": [
"In this paper we report the construction of a 3D model for this enzyme based on the structure of mouse acetylcholinesterase complexed with fasciculin ."
],
"offsets": [
[
0,
151
]
]
}
]
| [
{
"id": "split_0_train_1024_entity",
"type": "progene_text",
"text": [
"acetylcholinesterase"
],
"offsets": [
[
103,
123
]
],
"normalized": []
},
{
"id": "split_0_train_1025_entity",
"type": "progene_text",
"text": [
"fasciculin"
],
"offsets": [
[
139,
149
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_778 | split_0_train_778 | [
{
"id": "split_0_train_778_passage",
"type": "progene_text",
"text": [
"The model reveals the topological organization of the fold corroborating our predictions ."
],
"offsets": [
[
0,
90
]
]
}
]
| []
| []
| []
| []
|
split_0_train_779 | split_0_train_779 | [
{
"id": "split_0_train_779_passage",
"type": "progene_text",
"text": [
"As regarding the active - site residues , Ser155 , Asp252 , and His282 are located close to each other at hydrogen bond distances ."
],
"offsets": [
[
0,
131
]
]
}
]
| []
| []
| []
| []
|
split_0_train_780 | split_0_train_780 | [
{
"id": "split_0_train_780_passage",
"type": "progene_text",
"text": [
"Their catalytic role was here probed by biochemical and mutagenic studies ."
],
"offsets": [
[
0,
75
]
]
}
]
| []
| []
| []
| []
|
split_0_train_781 | split_0_train_781 | [
{
"id": "split_0_train_781_passage",
"type": "progene_text",
"text": [
"Moreover , on the basis of the secondary structure - driven multiple sequence alignment and the 3D structural model , a residue supposed important for catalysis , Gly84 , was mutated to Ser ."
],
"offsets": [
[
0,
191
]
]
}
]
| []
| []
| []
| []
|
split_0_train_782 | split_0_train_782 | [
{
"id": "split_0_train_782_passage",
"type": "progene_text",
"text": [
"The activity of the mutated enzyme was drastically reduced ."
],
"offsets": [
[
0,
60
]
]
}
]
| []
| []
| []
| []
|
split_0_train_783 | split_0_train_783 | [
{
"id": "split_0_train_783_passage",
"type": "progene_text",
"text": [
"We propose that Gly84 is part of a putative \" oxyanion hole \" involved in the stabilization of the transition state similar to the C group of the esterase / lipase family ."
],
"offsets": [
[
0,
172
]
]
}
]
| [
{
"id": "split_0_train_1026_entity",
"type": "progene_text",
"text": [
"esterase / lipase family"
],
"offsets": [
[
146,
170
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_784 | split_0_train_784 | [
{
"id": "split_0_train_784_passage",
"type": "progene_text",
"text": [
"Identification of a human histone acetyltransferase related to monocytic leukemia zinc finger protein ."
],
"offsets": [
[
0,
103
]
]
}
]
| [
{
"id": "split_0_train_1027_entity",
"type": "progene_text",
"text": [
"histone acetyltransferase"
],
"offsets": [
[
26,
51
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_785 | split_0_train_785 | [
{
"id": "split_0_train_785_passage",
"type": "progene_text",
"text": [
"We describe here the identification and functional characterization of a novel human histone acetyltransferase , termed MORF ( monocytic leukemia zinc finger protein - related factor ) ."
],
"offsets": [
[
0,
186
]
]
}
]
| [
{
"id": "split_0_train_1028_entity",
"type": "progene_text",
"text": [
"histone acetyltransferase"
],
"offsets": [
[
85,
110
]
],
"normalized": []
},
{
"id": "split_0_train_1029_entity",
"type": "progene_text",
"text": [
"MORF"
],
"offsets": [
[
120,
124
]
],
"normalized": []
},
{
"id": "split_0_train_1030_entity",
"type": "progene_text",
"text": [
"monocytic leukemia zinc finger protein - related factor"
],
"offsets": [
[
127,
182
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_786 | split_0_train_786 | [
{
"id": "split_0_train_786_passage",
"type": "progene_text",
"text": [
"MORF is a 1781 - residue protein displaying significant sequence similarity to MOZ ( monocytic leukemia zinc finger protein ) ."
],
"offsets": [
[
0,
127
]
]
}
]
| [
{
"id": "split_0_train_1031_entity",
"type": "progene_text",
"text": [
"MORF"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_1032_entity",
"type": "progene_text",
"text": [
"MOZ"
],
"offsets": [
[
79,
82
]
],
"normalized": []
},
{
"id": "split_0_train_1033_entity",
"type": "progene_text",
"text": [
"monocytic leukemia zinc finger protein"
],
"offsets": [
[
85,
123
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_787 | split_0_train_787 | [
{
"id": "split_0_train_787_passage",
"type": "progene_text",
"text": [
"MORF is ubiquitously expressed in adult human tissues , and its gene is located at human chromosome band 10q22 ."
],
"offsets": [
[
0,
112
]
]
}
]
| [
{
"id": "split_0_train_1034_entity",
"type": "progene_text",
"text": [
"MORF"
],
"offsets": [
[
0,
4
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_788 | split_0_train_788 | [
{
"id": "split_0_train_788_passage",
"type": "progene_text",
"text": [
"MORF has intrinsic histone acetyltransferase activity ."
],
"offsets": [
[
0,
55
]
]
}
]
| [
{
"id": "split_0_train_1035_entity",
"type": "progene_text",
"text": [
"MORF"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_1036_entity",
"type": "progene_text",
"text": [
"histone acetyltransferase"
],
"offsets": [
[
19,
44
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_789 | split_0_train_789 | [
{
"id": "split_0_train_789_passage",
"type": "progene_text",
"text": [
"In addition to its histone acetyltransferase domain , MORF possesses a strong transcriptional repression domain at its N terminus and a highly potent activation domain at its C terminus ."
],
"offsets": [
[
0,
187
]
]
}
]
| [
{
"id": "split_0_train_1037_entity",
"type": "progene_text",
"text": [
"histone acetyltransferase"
],
"offsets": [
[
19,
44
]
],
"normalized": []
},
{
"id": "split_0_train_1038_entity",
"type": "progene_text",
"text": [
"MORF"
],
"offsets": [
[
54,
58
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_790 | split_0_train_790 | [
{
"id": "split_0_train_790_passage",
"type": "progene_text",
"text": [
"Therefore , MORF is a novel histone acetyltransferase that contains multiple functional domains and may be involved in both positive and negative regulation of transcription ."
],
"offsets": [
[
0,
175
]
]
}
]
| [
{
"id": "split_0_train_1039_entity",
"type": "progene_text",
"text": [
"MORF"
],
"offsets": [
[
12,
16
]
],
"normalized": []
},
{
"id": "split_0_train_1040_entity",
"type": "progene_text",
"text": [
"histone acetyltransferase"
],
"offsets": [
[
28,
53
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_791 | split_0_train_791 | [
{
"id": "split_0_train_791_passage",
"type": "progene_text",
"text": [
"Hmg-coA reductase gene family in cotton ( Gossypium hirsutum L. ) : unique structural features and differential expression of hmg2 potentially associated with synthesis of specific isoprenoids in developing embryos ."
],
"offsets": [
[
0,
216
]
]
}
]
| [
{
"id": "split_0_train_1041_entity",
"type": "progene_text",
"text": [
"Hmg-coA reductase gene family"
],
"offsets": [
[
0,
29
]
],
"normalized": []
},
{
"id": "split_0_train_1042_entity",
"type": "progene_text",
"text": [
"hmg2"
],
"offsets": [
[
126,
130
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_792 | split_0_train_792 | [
{
"id": "split_0_train_792_passage",
"type": "progene_text",
"text": [
"As a first step towards understanding the biosynthesis of isoprenoids that accumulate in specialized pigment glands of cotton at the molecular level , two full - length genes ( hmg1 and hmg2 ) were characterized encoding hmg-coA reductase ( HMGR ; EC 1.1.1.34 ) , the enzyme that catalyzes the formation of a key isoprenoid precursor ."
],
"offsets": [
[
0,
335
]
]
}
]
| [
{
"id": "split_0_train_1043_entity",
"type": "progene_text",
"text": [
"hmg1"
],
"offsets": [
[
177,
181
]
],
"normalized": []
},
{
"id": "split_0_train_1044_entity",
"type": "progene_text",
"text": [
"hmg2"
],
"offsets": [
[
186,
190
]
],
"normalized": []
},
{
"id": "split_0_train_1045_entity",
"type": "progene_text",
"text": [
"hmg-coA reductase"
],
"offsets": [
[
221,
238
]
],
"normalized": []
},
{
"id": "split_0_train_1046_entity",
"type": "progene_text",
"text": [
"HMGR"
],
"offsets": [
[
241,
245
]
],
"normalized": []
},
{
"id": "split_0_train_1047_entity",
"type": "progene_text",
"text": [
"EC 1.1.1.34"
],
"offsets": [
[
248,
259
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_793 | split_0_train_793 | [
{
"id": "split_0_train_793_passage",
"type": "progene_text",
"text": [
"Cotton hmgr genes exhibited features typical of other plant genes , however , hmg2 encodes the largest of all plant HMGR enzymes described to date ."
],
"offsets": [
[
0,
148
]
]
}
]
| [
{
"id": "split_0_train_1048_entity",
"type": "progene_text",
"text": [
"hmgr"
],
"offsets": [
[
7,
11
]
],
"normalized": []
},
{
"id": "split_0_train_1049_entity",
"type": "progene_text",
"text": [
"hmg2"
],
"offsets": [
[
78,
82
]
],
"normalized": []
},
{
"id": "split_0_train_1050_entity",
"type": "progene_text",
"text": [
"HMGR"
],
"offsets": [
[
116,
120
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_794 | split_0_train_794 | [
{
"id": "split_0_train_794_passage",
"type": "progene_text",
"text": [
"HMG2 contains several novel features that may represent functional specialization of this particular HMGR isoform ."
],
"offsets": [
[
0,
115
]
]
}
]
| [
{
"id": "split_0_train_1051_entity",
"type": "progene_text",
"text": [
"HMG2"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_1052_entity",
"type": "progene_text",
"text": [
"HMGR"
],
"offsets": [
[
101,
105
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_795 | split_0_train_795 | [
{
"id": "split_0_train_795_passage",
"type": "progene_text",
"text": [
"Such features include a unique 42 amino acid sequence located in the region separating the N - terminal domain and C - terminal catalytic domain , as well as an N - terminal hydrophobic domain that is not found in HMG1 or other HMGR enzymes ."
],
"offsets": [
[
0,
242
]
]
}
]
| [
{
"id": "split_0_train_1053_entity",
"type": "progene_text",
"text": [
"HMG1"
],
"offsets": [
[
214,
218
]
],
"normalized": []
},
{
"id": "split_0_train_1054_entity",
"type": "progene_text",
"text": [
"HMGR"
],
"offsets": [
[
228,
232
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_796 | split_0_train_796 | [
{
"id": "split_0_train_796_passage",
"type": "progene_text",
"text": [
"DNA blot analysis revealed that hmg1 and hmg2 belong to small subfamilies that probably include homeologous loci in allotetraploid cotton ( Gossypium hirsutum L. ) ."
],
"offsets": [
[
0,
165
]
]
}
]
| [
{
"id": "split_0_train_1055_entity",
"type": "progene_text",
"text": [
"hmg1"
],
"offsets": [
[
32,
36
]
],
"normalized": []
},
{
"id": "split_0_train_1056_entity",
"type": "progene_text",
"text": [
"hmg2"
],
"offsets": [
[
41,
45
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_797 | split_0_train_797 | [
{
"id": "split_0_train_797_passage",
"type": "progene_text",
"text": [
"Ribonuclease protection assays revealed that hmg1 and hmg2 are differentially expressed in a developmentally - and spatially - modulated manner during morphogenesis of specialized terpenoid - containing pigment glands in embryos ."
],
"offsets": [
[
0,
230
]
]
}
]
| [
{
"id": "split_0_train_1057_entity",
"type": "progene_text",
"text": [
"Ribonuclease"
],
"offsets": [
[
0,
12
]
],
"normalized": []
},
{
"id": "split_0_train_1058_entity",
"type": "progene_text",
"text": [
"hmg1"
],
"offsets": [
[
45,
49
]
],
"normalized": []
},
{
"id": "split_0_train_1059_entity",
"type": "progene_text",
"text": [
"hmg2"
],
"offsets": [
[
54,
58
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_798 | split_0_train_798 | [
{
"id": "split_0_train_798_passage",
"type": "progene_text",
"text": [
"Induced expression of hmg2 coincided with a possible commitment to sesquiterpenoid biosynthesis in developing embryos , although other developmental processes also requiring HMGR cannot be excluded ."
],
"offsets": [
[
0,
199
]
]
}
]
| [
{
"id": "split_0_train_1060_entity",
"type": "progene_text",
"text": [
"hmg2"
],
"offsets": [
[
22,
26
]
],
"normalized": []
},
{
"id": "split_0_train_1061_entity",
"type": "progene_text",
"text": [
"HMGR"
],
"offsets": [
[
174,
178
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_799 | split_0_train_799 | [
{
"id": "split_0_train_799_passage",
"type": "progene_text",
"text": [
"The katX gene of Bacillus subtilis is under dual control of sigmaB and sigmaF ."
],
"offsets": [
[
0,
79
]
]
}
]
| [
{
"id": "split_0_train_1062_entity",
"type": "progene_text",
"text": [
"katX"
],
"offsets": [
[
4,
8
]
],
"normalized": []
},
{
"id": "split_0_train_1063_entity",
"type": "progene_text",
"text": [
"sigmaB"
],
"offsets": [
[
60,
66
]
],
"normalized": []
},
{
"id": "split_0_train_1064_entity",
"type": "progene_text",
"text": [
"sigmaF"
],
"offsets": [
[
71,
77
]
],
"normalized": []
}
]
| []
| []
| []
|
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