bvand086/sciwritingdataset · Datasets at Hugging Face

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portant to acknowledge, however, that this group of par-
ticipants was a small sample size of only 10 respondents
From these participants, cannabinoid products were felt to
play a different role in treating their dystonia
Further
investigation is required to determine if patients using
cannabinoids exclusively for their vocal dystonia are able
to do so due to less severe symptoms at baseline relative to
other patients
In a survey of 496 patients conducted by
Pandey et al
(2019), over 50% of the respondents reported
improvements in their dystonia symptoms after using
medical cannabis.17 The most common benefits reported
were reduced pain, improved sleep, and reduced anxiety
In this study, cannabinoids were felt to be useful in
managing acute symptoms with immediate impact, while
BTX was more effective longitudinally managing their
dystonia
In this way, cannabinoids were helpful managing
symptoms in the period between BTX injections and
FIGURE 8
Table displaying descriptive responses from participants about their perspectives on the role of cannabinoids in treating
vocal dystonia
Noah Millman, et al Cannabinoid Use in the Treatment of Laryngeal Dystonia 7
Downloaded for Anonymous User (n/a) at McMaster University from ClinicalKey.com by Elsevier on September 08,
2023
For personal use only
No other uses without permission
Copyright ©2023
Elsevier Inc
All rights reserved
elongated the time interval between injections
Future
studies would be helpful in further exploring the sub-
jectively increased time intervals between BTX injections
as well as further investigating the effects of varying can-
nabinoid dosages on perceived efficacy
Although it is uncertain if cannabinoids play a direct role
in addressing the physiological cause of laryngeal dystonia/
vocal tremor/MTD, participants often reported an indirect
benefit in using cannabinoid products as these products
helped relieve the stress and anxiety that frequently ex-
acerbate their vocal condition
LIMITATIONS
As an electronic survey, this study is limited to participants
who have Internet access
The electronic link was dis-
tributed exclusively through the Dystonia International
(previously National Spasmodic Dysphonia Association)
listserv, limiting the diversity of the sample population
The
intrinsic nature of online surveys can also predispose to
self-selection bias as participants choose to participate in
the survey potentially based on pre-existing bias
Patients
with a positive response to cannabinoids may have been
more likely to respond, while those who had never con-
sidered cannabinoids may have not had as pronounced
interest in responding
This may be reflected in the low
percentage response rate, with only 158 responses in a
collection of 5000 total emails in the listserv
However, it
would be inaccurate to attribute the low response rate to
selection bias alone, as the listserv was comprised of not
just patients, but also physicians and healthcare profes -
sionals
Without knowing the exact number of patients in
the listserv, the true response rate is difficult to calculate
As this study required participants to retrospectively recall
the extent of effectiveness after using cannabinoid pro-
ducts, there is likely recall bias that is affecting the col-
lected data
CONCLUSION
A considerable number of patients with vocal dystonia
have tried using cannabinoid products or currently use
cannabinoids to treat their laryngeal dystonia, vocal
tremor, and MTD
Most participants considered cannabi -
noids as either less effective or similarly effective to other
treatments in treating their vocal dystonia
A select group
of participants who used cannabinoids with Botox injec -
tions reported the combination as more effective than using
Botox alone
A prospective study is warranted for further
investigation to help clinicians counsel patients in their
treatment journey
Appendix A
Supporting information
Supplementary data associated with this article can be found
in the online version at doi:10.1016/j.jvoice.2023.05.006
REFERENCES
1.Cannito MP, Johnson JP
Spastic dysphonia: a continuum disorder
J
Commun Disord
1981;14:215–233
https://doi.org/10.1016/0021-9924(81)

portant to acknowledge, however, that this group of par-

ticipants was a small sample size of only 10 respondents

From these participants, cannabinoid products were felt to

play a different role in treating their dystonia

Further

investigation is required to determine if patients using

cannabinoids exclusively for their vocal dystonia are able

to do so due to less severe symptoms at baseline relative to

other patients

In a survey of 496 patients conducted by

Pandey et al

(2019), over 50% of the respondents reported

improvements in their dystonia symptoms after using

medical cannabis.17 The most common benefits reported

were reduced pain, improved sleep, and reduced anxiety

In this study, cannabinoids were felt to be useful in

managing acute symptoms with immediate impact, while

BTX was more effective longitudinally managing their

dystonia

In this way, cannabinoids were helpful managing

symptoms in the period between BTX injections and

FIGURE 8

Table displaying descriptive responses from participants about their perspectives on the role of cannabinoids in treating

vocal dystonia

Noah Millman, et al Cannabinoid Use in the Treatment of Laryngeal Dystonia 7

Downloaded for Anonymous User (n/a) at McMaster University from ClinicalKey.com by Elsevier on September 08,

2023

For personal use only

No other uses without permission

Elsevier Inc

elongated the time interval between injections

Future

studies would be helpful in further exploring the sub-

jectively increased time intervals between BTX injections

as well as further investigating the effects of varying can-

nabinoid dosages on perceived efficacy

Although it is uncertain if cannabinoids play a direct role

in addressing the physiological cause of laryngeal dystonia/

vocal tremor/MTD, participants often reported an indirect

benefit in using cannabinoid products as these products

helped relieve the stress and anxiety that frequently ex-

acerbate their vocal condition

LIMITATIONS

As an electronic survey, this study is limited to participants

who have Internet access

The electronic link was dis-

tributed exclusively through the Dystonia International

(previously National Spasmodic Dysphonia Association)

listserv, limiting the diversity of the sample population

The

intrinsic nature of online surveys can also predispose to

self-selection bias as participants choose to participate in

the survey potentially based on pre-existing bias

Patients

with a positive response to cannabinoids may have been

more likely to respond, while those who had never con-

sidered cannabinoids may have not had as pronounced

interest in responding

This may be reflected in the low

percentage response rate, with only 158 responses in a

collection of 5000 total emails in the listserv

However, it

would be inaccurate to attribute the low response rate to

selection bias alone, as the listserv was comprised of not

just patients, but also physicians and healthcare profes -

sionals

Without knowing the exact number of patients in

the listserv, the true response rate is difficult to calculate

As this study required participants to retrospectively recall

the extent of effectiveness after using cannabinoid pro-

ducts, there is likely recall bias that is affecting the col-

lected data

CONCLUSION

A considerable number of patients with vocal dystonia

have tried using cannabinoid products or currently use

cannabinoids to treat their laryngeal dystonia, vocal

tremor, and MTD

Most participants considered cannabi -

noids as either less effective or similarly effective to other

treatments in treating their vocal dystonia

A select group

of participants who used cannabinoids with Botox injec -

tions reported the combination as more effective than using

Botox alone

A prospective study is warranted for further

investigation to help clinicians counsel patients in their

treatment journey

Appendix A

Supporting information

Supplementary data associated with this article can be found

in the online version at doi:10.1016/j.jvoice.2023.05.006

REFERENCES

1.Cannito MP, Johnson JP

Spastic dysphonia: a continuum disorder

J

Commun Disord

1981;14:215–233

https://doi.org/10.1016/0021-9924(81)