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Map Adverse Drug Events (ADEs) mentioned in text data to their most relevant Preferred MeDDRA terms.
Atrial fibrillation occurring in a patient taking etanercept plus methotrexate for rheumatoid arthritis.
Atrial fibrillation
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A review of the literature revealed two other cases of hepatic angiosarcoma in patients after long-term cyclophosphamide treatment.
Hepatic angiosarComa
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Hepatic angiosarcoma occurring after cyclophosphamide therapy: case report and review of the literature.
Hepatic angiosarComa
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We propose that cyclophosphamide be added to the list of exposures potentially associated with hepatic angiosarcoma.
Hepatic angiosarComa
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ARA-C is frequently associated with dermatologic toxicity, but this is only the second case of toxic epidermal necrolysis described in connection with this drug.
Arthropathy
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On the fifth day after administration of a high dose of ARA-C (2 g/m2 intravenously every 12 hours), she developed bullous lesions on the hands and soles that disseminated, evolving to necrosis, sepsis, and death on the 22nd day.
Dermatitis bullous
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Toxic epidermal necrolysis after the use of high-dose cytosine arabinoside.
Toxic epidermal necrolysis
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We report a fatal case of toxic epidermal necrolysis (TEN) resulting from a high dose of cytosine arabinoside (ARA-C).
Toxic epidermal necrolysis
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Quetiapine and obsessive-compulsive symptoms (OCS): case report and review of atypical antipsychotic-induced OCS.
Obsessive-compulsive disorder
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The first known report of quetiapine exacerbating OCS in a 43-year-old man with obsessive-compulsive disorder (OCD), trichotillomania, delusional disorder and bipolar II disorder is presented.
Obsessive-compulsive disorder
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He was diagnosed with possible serotonin syndrome; his symptoms resolved after clomipramine was stopped but before clozapine was restarted eight days later.
Serotonin syndrome
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OBJECTIVE: To report on the possible development of serotonin syndrome in a patient receiving clomipramine after clozapine was withdrawn from the treatment regimen.
Serotonin syndrome
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Possible serotonin syndrome associated with clomipramine after withdrawal of clozapine.
Serotonin syndrome
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The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused.
Agitation
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Quinine induced coagulopathy--a near fatal experience.
Coagulopathy
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The cause of his bleeding was a severe thrombocytopoaenia, induced by chronic ingestion of quinine.
Thrombocytopenia
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Dose-dependent olanzapine-associated leukopenia: three case reports.
Leukopenia
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These cases suggest the possibility that, in some patients, leukopenia or agranulocytosis during olanzapine treatment might be dose-related.
Agranulocytosis
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We report three cases of patients who developed leukopenia during olanzapine treatment.
Leukopenia
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Differential diagnoses included ocular rosacea with cicatrizing conjunctivitis and 5-FU-induced ectropion.
Ectropion
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DISCUSSION: Patients with 5-FU-induced ectropion experience tender, red, scaled lids, making contact lens wear difficult.
Ectropion
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Ectropion secondary to bolus injection of 5-fluorouracil.
Ectropion
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Exacerbation of 5-FU dermatologic toxicities in patients with preexisting conditions suggests the importance of aggressive ocular prophylaxis, using frequent ocular lubrication and topical steroid preparations with concurrent medical management of pre-existing dermatologic conditions.
Dermatitis
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Presented is a case of acute renal failure induced by acetazolamide therapy for glaucoma.
Acute kidney injury
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Renal failure associated with acetazolamide therapy for glaucoma.
Renal failure
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This sulfonamide like nephropathy should be differentiated from acetazolamide-related calcium phosphate nephrolithiasis.
Nephrolithiasis
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Ischaemic colitis in a patient taking meloxicam.
Ischaemic Colitis
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Symptoms and endoscopic lesions quickly regressed within 1 week of meloxicam withdrawal.
Gastric mucosal lesion
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We describe a patient who presented with bloody diarrhoea after 15 mg meloxicam daily for 10 days for osteoarthritis.
Diarrhoea haemorrhagic
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We suggest that meloxicam might have intestinal toxic effects when taken in high doses, because of reduced COX-2 selectivity.
Enteritis
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As these cases revealed, close monitoring of blood chemistry is mandatory after starting spironolactone, and patients should be advised to stop spironolactone immediately if diarrhoea develops.
Diarrhoea
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In patients with chronic heart failure, spironolactone added to conventional treatment may lead to serious and, occasionally, fatal hyperkalaemia.
Hyperkalaemia
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In some cases this seems to happen because spironolactone causes diarrhoea.
Diarrhoea
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Serious adverse events experienced by patients with chronic heart failure taking spironolactone.
Hyperkalaemia
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We report a patient with advanced colonic carcinoma who was treated with concomitant chemoirradiation with oxaliplatin and developed a peculiar dermnatitis in the irradiated field after being exposed to subsequent chemotherapy with oxaliplatin.
Colorectal cancer
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An 11-year-old boy developed a severe enteropathy 2 years after initiation of clofazimine treatment for graft-versus-host disease.
Autoimmune enteropathy
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Clofazimine enteropathy caused by crystal deposition can be life-threatening.
Autoimmune enteropathy
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Clofazimine enteropathy in a pediatric bone marrow transplant recipient.
Autoimmune enteropathy
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She developed a severe urticarial rash 3 weeks following initiation of therapy with Enoxaparin.
Urticaria
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We cared for a patient with progressive renal impairment who presented with blurred vision, QRS broadening and cardiac failure due to chronic cibenzoline intoxication.
Vision blurred
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Indolent aspergillus arthritis complicating fludarabine-based non-myeloablative stem cell transplantation.
Arthritis fungal
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We describe two patients with aspergillus arthritis of the knee joint following fludarabine-based non-myeloablative stem cell transplantation.
Arthritis fungal
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CONCLUSION: The present findings suggest that fluvoxamine can cause increased libido in some patients.
Libido increased
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Increased libido in a woman treated with fluvoxamine: a case report.
Libido increased
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OBJECTIVE: The aim of this paper is to describe a case of increased libido during fluvoxamine therapy.
Libido increased
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RESULTS: The patient, a 27-year-old married Japanese woman with borderline personality disorder, developed an increased libido with the administration of fluvoxamine.
Libido increased
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The increased libido disappeared after fluvoxamine was discontinued.
Libido increased
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An infant who developed pancreatitis during meglumine antimoniate treatment for visceral leishmaniasis and who was successfully treated with a combination of allopurinol and ketoconazole is reported.
Pancreatitis
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Successful treatment of visceral leishmaniasis with allopurinol plus ketoconazole in an infant who developed pancreatitis caused by meglumine antimoniate.
Pancreatitis
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CONCLUSIONS: This case report showed that the clinical appearance of Hashimoto's disease after IFN-alpha therapy for chronic C hepatitis in our patient was associated with a specific genetic predisposition (DR5) for this pathology.
Autoimmune thyroiditis
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Further studies are necessary to evaluate whether the study of HLA antigens may be a very useful tool to detect the patients with a predisposition to develop autoimmune thyroiditis, in order to make a early diagnosis of thyroid disorders during the IFN-alpha treatment.
Autoimmune thyroiditis
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Hashimoto's disease during interferon-alpha therapy in a patient with pre-treatment negative anti-thyroid autoantibodies and with the specific genetic susceptibility to the thyroid disease.
Autoimmune thyroiditis
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OBJECTIVES: The authors described a case of Hashimoto's disease during interferon-alpha (IFN-alpha) treatment for chronic viral C hepatitis in a patient with the specific genetic susceptibility associated with the thyroid disease.
Autoimmune thyroiditis
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During dose-finding studies for intravenous proton pump inhibitors omeprazole and pantoprazole, three of six young female volunteers receiving omeprazole and two young female volunteers receiving pantoprazole developed peripheral edema within 8 hr when high doses of the proton pump inhibitors were applied by continuous infusion together with large volumes of fluid.
OOedema peripheral
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Pheripheral edema was observed in five female patients after taking proton pump inhibitors omeprazole, lansoprazole, or pantoprazole for 7-15 days for peptic acid diseases in recommended standard doses.
OOedema peripheral
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Motor fluctuations appear after 2-3 years of levodopa treatment, and affect at least 50% of patients after five years.
On and off phenomenon
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CONCLUSION: Significant weight loss is a potential adverse event in patients with rheumatoid arthritis treated with leflunomide.
Weight decreased
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Leflunomide-associated weight loss in rheumatoid arthritis.
Weight decreased
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METHODS: We queried 35 rheumatologists at the Robert Breck Brigham Arthritis Center to determine if weight loss had occurred as an adverse event in patients treated with leflunomide between November 1998 and January 2000.
Weight decreased
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OBJECTIVE: To determine the frequency of weight loss in patients treated with leflunomide for rheumatoid arthritis at an arthritis referral center.
Weight decreased
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RESULTS: Five of 70 patients who had begun leflunomide therapy had significant weight loss that could not be linked to other identifiable etiologies.
Weight decreased
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It is increasingly recognized that dose adjustment of oral valacyclovir in renal failure is necessary to avoid neurotoxicity.
Neurotoxicity
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Neurotoxicity of valacyclovir in peritoneal dialysis: a pharmacokinetic study.
Neurotoxicity
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She developed neurotoxicity with an adjustment dosage of valacyclovir for a cutaneous zoster infection.
Neurotoxicity
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Avascular necrosis of the femoral head in patients with prostate cancer treated with cyproterone acetate and radiotherapy.
Osteonecrosis
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We report the case histories of two patients with histologically confirmed adenocarcinoma of the prostate, both of whom had been treated with steroidal anti-androgen therapy in the form of cyproterone acetate prior to radical or palliative pelvic irradiation, and who subsequently developed femoral head avascular necrosis.
Osteonecrosis
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Levofloxacin induced polymorphic ventricular tachycardia with normal QT interval.
Ventricular tachycardia
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We report the first case of polymorphic ventricular tachycardia with normal QT interval associated with the oral use of levofloxacin in the absence of other etiologies known to cause these arrhythmias.
Ventricular tachycardia
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So far, few cases of pulmonary side effects caused by ticlopidine have been reported.
Respiratory disorder
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Special care should be taken when pulmonary symptoms appear in association with ticlopidine treatment.
Respiratory disorder
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Ticlopidine-induced interstitial pulmonary disease: a case report.
Interstitial lung disease
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We report a case of interstitial pulmonary disease that occurred together with lymphocytic colitis during treatment with ticlopidine.
Interstitial lung disease
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A patient that received methadone for cancer-associated pain developed myoclonus as a side effect.
Myoclonus
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Methadone-induced myoclonus in advanced cancer.
Myoclonus
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OBJECTIVE: To report a case of fatal hyperkalemia owing to succinylcholine administration in a patient with mucositis secondary to chemotherapy.
Hyperkalaemia
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Succinylcholine-induced hyperkalemia in a patient with mucositis secondary to chemotherapy.
Hyperkalaemia
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We believe that mucositis was a contributing factor to this case of fatal hyperkalemia after administration of succinylcholine, with a mechanism similar to that reported with thermal injury.
Hyperkalaemia
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Cutaneous seeding after ultrasound-guided percutaneous ethanol injection for treatment of hepatocellular carcinoma.
Skin infection
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We describe a case of needle-track cutaneous seeding of hepatocellular carcinoma (HCC) after sonographically guided percutaneous ethanol injection (PEI).
Skin infection
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Adenosine-induced ventricular fibrillation.
Ventricular fibrillation
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However, adenosine shortens the antegrade refractoriness of accessory atrioventricular connections and may cause acceleration of the ventricular rate during atrial fibrillation.
Tachycardia
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We observed ventricular fibrillation in 2 patients who presented to the emergency department with pre-excited atrial fibrillation and were given 12 mg of adenosine.
Ventricular fibrillation
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After the dose of methylprednisolone was reduced from 40 mg to 20 mg i.v. q6h and shifted to other anti-asthma treatment by procaterol metered dose inhaler via spacer, the psychotic reaction disappeared a few hours later.
Acute Psychotic disorder
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Continuous EEG monitoring is helpful in managing seizures that occur as a complication of CBZ OD, after the course of recovery or worsening, and in providing assistance with prognosis.
Seizure
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Massive CBZ OD may produce a reversible encephalopathy that includes cortical hyperexcitability, a profound burst-suppression EEG pattern, and cranial nerve areflexia.
Hyperexcitability
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Massive plasmocytosis due to methimazole-induced bone marrow toxicity.
Myelosuppression
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To our knowledge this is the first report of pancytopenia due to MMI, where the usual hypoplasia found is replaced by massive plasmocytosis.
Myelosuppression
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We report a case of fulminant hepatic failure associated with didanosine and masquerading as a surgical abdomen and compare the clinical, biologic, histologic, and ultrastructural findings with reports described previously.
Acute hepatic failure
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This report details a case of bilateral avascular necrosis of the femoral heads in a patient receiving 'standard' doses of dexamethasone as part of the antiemetic regimen used in cisplatin-based combination chemotherapy.
Osteonecrosis
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Although no coagulation study was done and the Meckel's diverticulum is normally associated with bleeding, the particular intensity of the following hemorrhage may have been favored by metformin.
Haemorrhage
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An obese patient, not diabetic, treated with metformin for some weeks, was referred to us with severe inferior digestive hemorrhage, diagnosed with Meckel's diverticulum.
Gastrointestinal Haemorrhage
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Digestive hemorrhage caused by a Meckel's diverticulum in a metformin-treated patient: is there any connection?
Digestive Haemorrhage
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Ulcer became worse after tobramycin and gentamycin treatment for 2 days.
Ulcer became worse
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Possible linkage of amprenavir with intracranial bleeding in an HIV-infected hemophiliac.
Haemorrhage intracranial
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The bleeding resolved on discontinuation of APV.
Haemorrhage
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We report the occurrence of spontaneous intracranial bleeding in an human immunodeficiency virus (HIV)-infected adolescent with hemophilia A who was receiving amprenavir (APV).
Haemorrhage intracranial
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According to the Naranjo probability scale, the relationship of gemcitabine treatment with cutaneous eruption in our patient is possible.
Toxic skin eruption
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CONCLUSIONS: We report the first case of gemcitabine-induced LABD.
Systemic Systemic lupus erythematosus erythematosus
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Linear immunoglobulin A bullous dermatosis induced by gemcitabine.
Dermatitis bullous
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OBJECTIVE: To report a case of linear immunoglobulin (Ig) A bullous dermatosis (LABD) induced by gemcitabine.
Systemic Systemic lupus erythematosus erythematosus