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The successful development and implementation of this protocol will have impact on patients who have anaphylactic reactions to MTX but require this medication for specific diseases.
Anaphylactic reaction
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The authors report a case of Balint syndrome with irreversible posterior leukoencephalopathy on MRI following intrathecal methotrexate and cytarabine.
Balint syndrome
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We present a unique case of GTBM in a patient with myeloma following treatment with Melphalan.
Plasma cell myeloma
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Patients with lymphoblastic lymphoma who had treatment with L-asparaginase and steroid are predisposed to the development of cortical venous thrombosis and may have this syndrome in addition to a dural puncture headache.
Cerebral venous Thrombosis
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Interstitial pneumonitis associated with sirolimus: a dilemma for lung transplantation.
Interstitial lung disease
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Rapamycin/sirolimus-induced pneumonitis has been described previously in renal transplant recipients, and this report describes a stable heart-lung transplant recipient who developed a pulmonary infiltrate that reversed after ceasing SR therapy.
Pneumonitis
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A 16-year-old boy developed fever, generalized rigidity, leukocytosis, and increased serum transaminase and creatine kinase levels while receiving treatment with olanzapine and lithium.
Pyrexia
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Concomitant administration of lithium with olanzapine may place patients at risk for NMS.
Neuroleptic malignant syndrome
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Neuroleptic malignant syndrome in an adolescent receiving olanzapine-lithium combination therapy.
Neuroleptic malignant syndrome
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Both 6-MP and AZA are widely used and are known to cause hepatotoxicity in a proportion of patients.
Hepatotoxicity
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Hepatotoxicity associated with 6-thioguanine therapy for Crohn's disease.
Hepatotoxicity
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This case highlights the need to monitor liver enzymes in patients treated with 6-TG and identifies the need for additional research focused on the mechanism of thiopurine-induced hepatic injury.
Drug-induced Liver injury
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We believe the temporal association of the abnormal liver enzymes in this patient, in the absence of other offending agents, argues strongly in favor of 6-TG as a cause of liver enzyme abnormalities.
Liver function test abnormal
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We describe a case of significant elevation of serum transaminases in a patient treated with 6-TG for a flare of Crohn's disease.
Transaminases increased
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Early peritoneal dialysis has not previously been reported for lisinopril induced multiorgan failure.
Multiple organ dysfunction syndrome
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We observed transient panhypogammaglobulinaemia in a patient with neuropsychiatric SLE after treatment with prednisolone and cyclophosphamide.
Hypogammaglobulinaemia
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Fulminant hepatic failure developed in a 24-year-old black woman who had been treated with propylthiouracil and propranolol for hyperthyroidism.
Acute hepatic failure
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Fulminant hepatitis and lymphocyte sensitization due to propylthiouracil.
Hepatitis fulminant
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These observations indicate that submassive hepatic necrosis may result from treatment with propylthiouracil and are consistent with the notion that sensitization mechanisms may be responsible for the hepatic injury induced by this drug.
Drug-induced Liver injury
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The diagnosis of hypothermia was delayed until it was apparent for several days but resolved with the discontinuation of risperidone and continuation of clozapine.
Hypothermia
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This is a case report of subtle, mild hypothermia in a 54-year old female patient receiving risperidone for schizophrenia.
Hypothermia
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Akathisia is a relatively rare side effect with the newer atypical antipsychotic agents, particularly clozapine, and is easily misdiagnosed in children.
Akathisia
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Clozapine-induced akathisia in children with schizophrenia.
Akathisia
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Two cases of childhood-onset schizophrenia associated with clozapine-induced akathisia responsive to beta-blocker treatment are described.
Akathisia
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After reviewing the literature we suggest the CPM was a complication of lithium toxicity which affected the lateral geniculate nucleus which produced blindness.
Blindness
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Central pontine myelinolysis manifested by temporary blindness: a possible complication of lithium toxicity.
Osmotic demyelination syndrome
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Antithyroid treatment with propylthiouracil (PTU) resulted in elevated hepatic enzymes and after the 12th week of pregnancy treatment was changed to carbimazole (CBZ).
Hepatic enzyme increased
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Successful treatment with carbimazole of a hyperthyroid pregnancy with hepatic impairment after propylthiouracil administration: a case report.
Hepatic function abnormal
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Interferon-alpha (IFN-alpha) may precipitate or exacerbate the occurrence of MPGN.
Hepatic function abnormalImmune-complex membranoproliferative glomerulonephritis
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Minimal change disease in a patient receiving IFN-alpha therapy for chronic hepatitis C virus infection.
Glomerulonephritis minimal lesion
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A 58-yr-old male patient with essential thrombocythaemia (ET) developed chronic myeloid leukaemia (CML) after continuous uneventful treatment with hydroxyurea for 18 yr.
Chronic myeloid leukaemia
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Emergence of Philadelphia positive chronic myeloid leukaemia during treatment with hydroxyurea for Philadelphia negative essential thrombocythaemia.
Philadelphia positive Chronic myeloid leukaemia
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There are no previous reports in the literature about the emergence of CML during treatment with hydroxyurea.
Chronic myeloid leukaemia
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A 72-year-old woman with a history of thyrotoxicosis presented with sore throat and fever two weeks after starting carbimazole.
Pyrexia
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Treatment of carbimazole-induced agranulocytosis and sepsis with granulocyte colony stimulating factor.
Agranulocytosis
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We present the management of agranulocytosis and neutropenic sepsis secondary to carbimazole with recombinant human granulocyte colony stimulating factor (G-CSF).
Agranulocytosis
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Comeoscleral perforation after pterygium excision and intraoperative mitomycin C.
Corneal perforation
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To the best of our knowledge, corneoscleral melting in the first postoperative week after a single intraoperative application of mitomycin C has not been reported.
Corneal perforation
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A 71-year-old man, who had a history of a previous bullous drug reaction to a sulfonamide, began receiving an ophthalmic preparation that contained sulfacetamide sodium.
Drug eruption
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The patient received only the ophthalmic sulfonamide, and it was used for one day, but he developed Stevens-Johnson syndrome.
Stevens-Johnson syndrome
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The sulfonamides are the best verified drug-trigger for erythema multiforme and Stevens-Johnson syndrome.
Erythema multiforme
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Based on these findings, the patient was diagnosed with diabetes insipidus secondary to lithium therapy and was treated successfully with amiloride.
Diabetes insipidus
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Treatment of lithium-induced diabetes insipidus with amiloride.
Diabetes insipidus
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Systemic capillary leak syndrome after granulocyte colony-stimulating factor (G-CSF).
Granulocyte-colony stimulating factor level increased
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We present two cases in which both patients suffered with CLS, which we believe was caused following administration of granulocyte colony-stimulating factor, to our knowledge not described in the intensive care patient previously.
Kawasaki's disease
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FK506, which began to be administered 12 days earlier, rose to a level of 44 ng/mL (normal range, 10-20 ng/mL) 1 day before neurologic abnormalities began.
Immune-mediated neurological disorder
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Rapid identification of speech loss linked to FK506 may be important because reduction or cessation of the drug may be associated with reverse of speech loss.
Aphasia
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Tacrolimus (FK506), an immunosuppressant, has been associated with mutism in adults after liver transplant.
Mutism
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Tacrolimus (FK506)-induced mutism after liver transplant.
Mutism
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Does the use of insulin in a patient with liver dysfunction increase water retention in the body, i.e. cause insulin oedema?
OOedema
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Soon after introduction of insulin therapy, she developed severe anasarca, including marked peripheral oedema, ascites and pleural effusion.
Ascites
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The induced hyperglycaemia could not be controlled sufficiently, despite a high dose of insulin (> 110 units/day), suggesting the existence of insulin insensitivity and hyperinsulinaemia.
Hyperinsulinaemia
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Intrathecal methotrexate-induced acute cerebellar syndrome.
Cerebellar syndrome
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We describe a patient who developed acute cerebellar syndrome after prophylactic intrathecal methotrexate administration and recovered spontaneously.
Cerebellar syndrome
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Angioimmunoblastic lymphadenopathy with dysproteinemia following doxycycline administration.
Angioimmunoblastic T-cell lymphoma
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We report a case of AILD in an 80-year-old male who presented with a generalized pruritic maculopapular eruption and fever following doxycycline administration.
Angioimmunoblastic T-cell lymphoma
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Anaphylaxis from isoniazid is a possible side effect to this commonly prescribed antibiotic.
Anaphylactic reaction
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Isoniazid-induced anaphylaxis.
Anaphylactic reaction
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A case is reported in which severe hypocalcemia, with a low plasma parathyroid hormone (PTH) concentration, resulted from the therapeutic use of magnesium sulfate for toxemia of pregnancy.
Hypoparathyroidism
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Carbamazepine-related hyponatremia following cardiopulmonary bypass.
Hyponatraemia
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We discuss the association between carbamazepine and hyponatremia and the causes of hyponatremia after cardiopulmonary bypass.
Hyponatraemia
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After 5-ASA was discontinued, the polyneuropathy symptoms recovered gradually.
PolyNeuropathy peripheral
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Sensorimotor polyneuropathy with 5-aminosalicylic acid: a case report.
Peripheral sensorimotor Neuropathy peripheral
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This clinical course suggests that the sensorimotor polyneuropathy may have been caused by 5-ASA.
Peripheral sensorimotor Neuropathy peripheral
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When SASP was changed to 5-aminosalicylic acid (5-ASA), his skin eruptions were resolved, however, he developed weakness and atrophy in his right arm as well as progressive worsening of the dysesthesia in his legs and gait disturbance.
Atrophy
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Disseminated cellulitic cryptococcosis in the setting of prednisone monotherapy for pemphigus vulgaris.
Cryptococcosis
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In both cases, high fever, skin rash, liver dysfunction and atypical lymphocytosis developed 3 weeks after initiating treatment with SASP.
Lymphocytosis
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Slow acetylator genotypes as a possible risk factor for infectious mononucleosis-like syndrome induced by salazosulfapyridine.
Infectious mononucleosis
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We report two patients with infectious mononucleosis-like syndrome induced by salazosulfapyridine (SASP).
Infectious mononucleosis
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A 45-year-old woman with steroid-dependent Crohn's colitis, successfully managed with maintenance infliximab infusions and methotrexate, developed a lupus-like syndrome eight months after her initial infusion.
Lupus-like syndrome
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A lupus-like syndrome associated with infliximab therapy.
Lupus-like syndrome
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Infliximab therapy may cause a lupus-like syndrome that is reversible upon discontinuing this agent.
Lupus-like syndrome
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We report in detail an unusual adverse reaction to infliximab therapy, a drug-induced lupus-like clinical syndrome.
Lupus-like syndrome
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Chronic myelogenous leukemia (CML), hepatitis C, and interferon alpha (IFNalpha) have all been associated with renal dysfunction.
Renal tubular dysfunction
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Despite the underlying hepatitis C, this case represents renal abnormalities consistent with IFNalpha therapy for CML.
Renal disorder
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Interferon-alpha-induced focal segmental glomerulosclerosis in chronic myelogenous leukemia: a case report and review of the literature.
Focal segmental glomerulosclerosis
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The renal biopsy showed focal segmental glomerulosclerosis, which has only been previously reported in two cases of CML treated with IFNalpha.
Focal segmental glomerulosclerosis
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Severe autoimmune hemolytic anemia following rituximab therapy in a patient with a lymphoproliferative disorder.
Autoimmune haemolytic Anaemia
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The pathophysiological mechanisms remain unknown, although the drug could act through massive cytokines liberation after destruction of CD20 positive cells by rituximab.
B-cell depletion therapy
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We report the first case, to our knowledge, of rituximab-related autoimmune hemolytic anemia.
Autoimmune haemolytic Anaemia
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Early-onset acute transverse myelitis following hepatitis B vaccination and respiratory infection: case report.
Myelitis transverse
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In this paper, we report a case of 3 years-old boy who developed acute onset tetraparesia following a viral respiratory infecction and hepatitis B vaccination.
Quadriparesis
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Although it would be expected that, like other type IA toxicities, diphenhydramine-induced cardiotoxicity could be responsive to hypertonic sodium bicarbonate, this finding is largely unappreciated.
Cardiotoxicity
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Diphenhydramine-induced wide complex dysrhythmia responds to treatment with sodium bicarbonate.
Arrhythmia
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However, because diphenhydramine also exhibits type IA sodium channel blockade, cardiac toxicity is also possible.
Cardiotoxicity
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We describe 3 cases of diphenhydramine-induced cardiac toxicity that were responsive to bicarbonate.
Cardiotoxicity
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We describe a patient with extranodal non-Hodgkin lymphoma who developed systemic candidiasis after treatment with a cyclophosphamide-based chemotherapy regimen.
Systemic candida
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Stevens-Johnson syndrome in a boy with nephrotic syndrome during prednisolone therapy.
Stevens-Johnson syndrome
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We report a case of SJS in a 14-year-old male with nephrotic syndrome, who was treated with oral prednisolone for 6 weeks.
SJS-Toxic epidermal necrolysis overlap
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A 25-year-old man with a history of mid-borderline (BB) Hansen's disease developing a reversal reaction after starting dapsone and rifampin therapy is presented.
Leprosy
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However, in order to avoid neuropathic side effects, patients under thalidomide therapy should be monitored every 6 months with nerve conduction studies while taking the drug.
Neuropathy peripheral peripheral
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After a two-month interruption of interferon administration, natural interferon alpha was given but followed by another episode of the same neurological manifestations.
Diabetic Neuropathy peripheral
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Case 1, a 62-year-old woman, developed bilateral optic neuritis with decreased sensation of vibration and increased deep tendon reflex in the lower extremities after a seven-month use of recombinant interferon alpha-2a for chronic active hepatitis C.
Optic neuritis
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Case 2, a 29-year-old woman, developed bilateral optic neuritis combined with numbness of the lower extremities as well as bowel and bladder dysfunction after a 22-month use of recombinant interferon alpha-2b for chronic myelogenous leukemia.
Optic neuritis
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CONCLUSIONS: Optic neuritis in combination with other neurological signs, simulating multiple sclerosis, should be included in the list of adverse effects of recombinant and natural interferon alpha administration.
Neurological symptom
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Multiple sclerosis-like disease secondary to alpha interferon.
Autoimmune demyelinating disease
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PURPOSE: To describe bilateral optic neuritis that occurred as an adverse effect of recombinant and natural interferon alpha administration.
Optic neuritis
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Acute abdomen due to endometriosis in a premenopausal woman taking tamoxifen.
Acute abdomen
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We describe a premenopausal woman who, while having tamoxifen due to a diagnosis of in situ ductal carcinoma, developed endometriosis requiring surgery.
Endometriosis
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A case report of fatal dapsone-induced agranulocytosis in an Indian mid-borderline leprosy patient.
Agranulocytosis