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0.475117 | b3a73da11b7442f98af7bf3d63df2ebd | Determination of DEGs between TAO and normal samples. The volcano plot showed all differentially expressed genes (DEGs) between TAO and normal samples. Red indicates that the expression of genes is relatively upregulated, and blue means that the expression of genes is relatively downregulated. The number of genes in each module is listed in Supplementary Table S1 | PMC10293385 | 12020_2023_3349_Fig1_HTML.jpg |
0.42174 | 5ca1f4f764b049b1bfdf4842eb96d6e7 | Determination of TAO-associated genes (TAGs) by weighted gene co-expression network analysis (WGCNA). A Analysis of network topology for various soft-thresholding powers. B Clustering dendrogram of genes, with dissimilarity based on the topological overlap and assigned module colors. C Module-trait associations. Each row corresponds to a module, and each column corresponds to a trait. Each cell contains the corresponding correlation and p value. The table is color-coded by correlation according to the color legend. Heatmap of the correlation between module eigengenes and the clinical modules | PMC10293385 | 12020_2023_3349_Fig2_HTML.jpg |
0.370545 | 682b54e94ffa422cb42f02d7ea1fce2a | Determination of TA-DMGs between TAO and normal samples. A Volcano plot of DMGs. B Venn plot of TAGs, DEGs, and DMGs between TAO and normal samples | PMC10293385 | 12020_2023_3349_Fig3_HTML.jpg |
0.523988 | 921f5260eb90485f81e8a93c85d52242 | Functional enrichment analysis of TA-DMGs and PPI network. A Gene Ontology (GO) functional and KEGG pathway enrichment analysis for TA-DMGs. B Protein–protein interaction network of the common differentially methylated genes (DMGs) set. Blue indicates downregulation while red represents upregulation | PMC10293385 | 12020_2023_3349_Fig4_HTML.jpg |
0.470814 | a7d2f17727e9407db13186bdcafd2104 | Diagnostic marker detection by machine learning. A, B The gene coefficient plot and cross-validation error plot were obtained from the lasso regression. Eight signature genes (ADAD2, ADAMTSL2, EHBP1, GPR144, MRPS6, NKD2, NRIP2, and S100A11) were screened. C, D The results of the SVM analysis. Eight signature genes were selected (GDE1, NKD2, PTTG1IP, ATP5J2, SGCE, S100A11, SKP1, and BNIP3L). E Venn plot of signature genes by lasso regression and SVM analysis | PMC10293385 | 12020_2023_3349_Fig5_HTML.jpg |
0.459798 | 2e2696542c8f4f0abd1f50c9d39f91cb | The diagnostic performance of machine learning for the prediction of biomarkers. A The receiver operating characteristic curve (ROC) of NKD2 and S100A11 in the training group. B The ROC curve of NKD2 and S100A11 in the validation set. C, D The boxplots of NKD2 and S100A11 in the GSE58331 and GSE105149 datasets. E Boxplot of the methylation levels of NKD2 and S100A11 in TAO samples and normal samples | PMC10293385 | 12020_2023_3349_Fig6_HTML.jpg |
0.492013 | 1ae9424f958848fe84792c95e8ff2f7a | GSEA for NKD2 and S100A11. A The GO result of NKD2. B The KEGG result of NKD2. C The GO result of S100A11. D The KEGG result of S100A11. Each line represents one particular gene set with unique color. Upregulated genes are located on the left, approaching the origin of the coordinates; by contrast, the downregulated lay on the right of the x-axis. Only gene sets with NOM p < 0.05 were considered significant, and only several leading gene sets were displayed in the plot | PMC10293385 | 12020_2023_3349_Fig7_HTML.jpg |
0.432107 | dbe1cf4d0a414ca3b2da1bfa0c5c5682 | Immune cell infiltration analysis in TAO. A Twelve differential immune cells were found between TAO and normal samples. B Heatmap of the correlation between NKD2 and s100A11 with immune cells in TAO. *p < 0.05, **p < 0.01 | PMC10293385 | 12020_2023_3349_Fig8_HTML.jpg |
0.496952 | 942eb19a4ccc4ddf9d3ed63ef316e3c8 | qRT-PCR for NKD2 and S100A11. A S100A11 was significantly downregulated in TAO. B NKD2 in TAO was significantly upregulated. *p < 0.05, **p < 0.01 | PMC10293385 | 12020_2023_3349_Fig9_HTML.jpg |
0.403466 | 76af10ce13b841ec84bd3cfa1b6bfba9 | Approximate hand movements during 90° turns to the right. (A) RT was achieved by propelling the wheelchair with both hands in the new direction synchronously. A black hand indicates right hand (inner hand), white hand indicates left hand (outer hand). Dashed gray arrows indicate direction of travel, thin black and gray arrows indicate approach pushes and depart pushes of the right and left hand, respectively. Thick black and gray arrows indicate the turning push of the right and left hand, respectively. Spin turn was executed by braking with the inner hand (black solid lines indicate braking periods) whilst the outer hand changed direction by spinning the wheelchair around the inner wheel by increasing the push frequency. Spin turn was sub-categorized by numbers of spinning pushes of the outer hand: (B) 1, (C) 2 or (D) 3 pushes. | PMC10293636 | fspor-05-1127514-g001.jpg |
0.543918 | 22efed9dffd54380a04bf8e09470f219 | Typical pattern of torque during a 2-spinning push turn to the right across time. A solid line indicates torque of the inner wheel (TRi). A dashed line indicates torque of the outer wheel (TLo). | PMC10293636 | fspor-05-1127514-g002.jpg |
0.470197 | 9a7b986f357747e28c75df864add2d1e | Comparisons of peak tangential force (Ft) and peak negative tangential force (Ftneg) across tasks. SSSFP, TRi inner hand of turn right, TLo outer hand of turn left. *Value different from the Ftneg turning phase of TRi. **Value different from the Ft turning phase of TRi. ***Value different from the Ft depart phase of TLo. | PMC10293636 | fspor-05-1127514-g003.jpg |
0.457352 | 1880717be0414dfd9b5c3bef2a8fc946 | In the single cue condition, where stimulus (S) 6 was trained as the threat-conditioned stimulus (CS+), participants showed the highest fear response to S6, with elevated fear responses observed for the nearby stimuli (S4, S5, S7, and S8) during the generalization test. Conversely, stimuli further away from S6 (S1, S2, S10, and S11) elicited lower levels of fear expectation, resulting in a quadratic trend overall. In the discrimination condition, where S1 was trained as the safe conditioned stimulus (CS−) and S6 as the CS+, a linear trend was observed from S1 to S6, with progressively stronger fear responses as the stimuli approached S6. Adjacent stimuli to the CS− (S2, S3) elicited weaker fear responses. | PMC10294887 | behavsci-13-00479-g001.jpg |
0.412649 | 653e69ac6cc04c2aa88fce486cf9b2e4 | (A) Circles of different diameters were used as the conditioned (CS) or generalization stimuli (GS). (B) Two contexts—black and gray—were investigated. | PMC10294887 | behavsci-13-00479-g002.jpg |
0.454505 | 8c29a448c1e34bf5a56fc3c75a5fce51 | The mean unconditioned stimulus (US) expectancy ratings were higher for the late acquisition phase than the early phase. There was no significant difference between the two types of context groups. Error bars represent one standard error of the mean. *** p < 0.001, ** p < 0.01. | PMC10294887 | behavsci-13-00479-g003.jpg |
0.498051 | 9cb01b5d302a49c78b10b62c139b1edd | Both types of context groups had higher mean US expectancy ratings for CS+ than CS−. Since trial 2, participants have learned the difference between the CS-US association of CS+ and CS−. Error bars represent one standard error of the mean. | PMC10294887 | behavsci-13-00479-g004.jpg |
0.498956 | 7d8b4e3f9a0443ee8b50b40cd43942ab | (A) The mean US expectancy ratings and generalization gradient in the single cue condition. (B) The mean US expectancy ratings and generalization gradient in the discrimination condition. The mean US expectancy ratings of all stimuli in the single cue condition were higher than the discrimination condition; specifically, S1, S2, and S4 had a significant difference between the two cue conditions. Error bars represent one standard error of the mean. | PMC10294887 | behavsci-13-00479-g005.jpg |
0.419593 | 872ed22cee12454c96d25873a7a52cf6 | The generalization gradient of linear and similarity rules in the two cue training conditions. In the single cue condition, the linear rule gradient showed the peak shift at S9, while the similarity rule gradient had a ‘flat’ gradient around S4–S8. In the discrimination condition, the linear rule gradient showed the peak shift at S11, and the similarity rule gradient showed a ‘convex’ gradient around S4–S8. Error bars represent one standard error of the mean. | PMC10294887 | behavsci-13-00479-g006.jpg |
0.413157 | 2ce9b4a20cb64a55871a4c738d24172a | The generalization gradient of the linear rule in the consistent context condition showed a significant linear trend and a significant quadratic trend. In the inconsistent context condition, only a significant linear trend was noted. Error bars represent one standard error of the mean. | PMC10294887 | behavsci-13-00479-g007.jpg |
0.460818 | a6060bd4330a4256816cd2057723585a | The peak shift and a main linear trend when using S1 as a safe cue; a main quadratic trend and no peak shift when using S11 as a safe cue. Error bars represent one standard error of the mean. | PMC10294887 | behavsci-13-00479-g008.jpg |
0.409403 | 2a3e0e6f181f48cda6ce5c11fed96ad8 | Flow diagram for selection process of rectal cancer patients. | PMC10294893 | bioengineering-10-00720-g001.jpg |
0.469892 | e46a628745b747f1b3cbdaebc9a2c305 | Bland–Altman analysis of PDFF, R2* and MTRasym (3.5 ppm) of patients with rectal cancer by two readers. | PMC10294893 | bioengineering-10-00720-g002.jpg |
0.463364 | 9cd1c725c13949398349b85c322bfeb2 | A 66-year-old male of rectal adenocarcinoma with T3 stage and no lymph node metastasis (moderately differentiated; EMVI-; MRF-). (a). axial T2-weighted imaging demonstrates a mass with moderate intensity in the rectum. (b). axial diffusion-weighted imaging indicates a mass with uneven high signal in the rectal lumen. (c). PDFF map with delineation of corresponding rectal tumor (PDFF = 3.60%). (d). R2* map with delineation of corresponding rectal tumor (R2* = 32.20 Hz). (e). pseudo-color map of APTWI indicates a mean MTRasym (3.5 ppm) of 3.56%. (f). Histopathological result indicates that the tumor invades the surrounding adipose tissue of rectum. | PMC10294893 | bioengineering-10-00720-g003.jpg |
0.507823 | 62f113a70e10405a8c61ba97f695d063 | A 49-year-old female of rectal adenocarcinoma with T3 stage and N2 lymph node metastasis (moderately differentiated; EMVI+; MRF−). (a). axial T2-weighted imaging demonstrates an irregular-shape mass with moderate intensity in the rectum. (b). axial diffusion-weighted imaging indicates a mass with mildly high signal in the rectal lumen. (c). PDFF map with delineation of corresponding rectal tumor (PDFF = 4.51%). (d). R2* map with delineation of corresponding rectal tumor (R2* = 32.41 Hz). (e). pseudo-color map of APTWI indicates a mean MTRasym (3.5 ppm) of 4.17%. (f). Histopathological result indicates that the tumor invades the surrounding adipose tissue of rectum, and locally breaks through the serosal layer of rectum. | PMC10294893 | bioengineering-10-00720-g004.jpg |
0.479625 | 43c14e2dfa90430f98379dd888fdcb42 | Correlation of MTRasym (3.5 ppm) with PDFF (r = 0.563, p < 0.001) and R2* (r = 0.335, p = 0.006). | PMC10294893 | bioengineering-10-00720-g005.jpg |
0.501027 | d1d0f974b0564c51b45b73a9e8ba07a6 | ROC curves of PDFF, R2* and MTRasym (3.5 ppm) for distinguishing metastatic/non-metastatic lymph nodes. ROC analysis demonstrated PDFF had a higher area under the curve (AUC = 0.858) than the other parameters. | PMC10294893 | bioengineering-10-00720-g006.jpg |
0.404681 | 37c117f0103c45958296b889a3c057df | Preparation and topical application of (tris(hydroxymethyl)-aminomethane)-modified bioadhesive nanoparticles (Tris-BNPs). (A) The synthesis of idebenone (IDB)-loaded Tris-BNPs (IDB/Tris-BNPs) from IDB-loaded non-bioadhesive nanoparticles (IDB/NNPs) and IDB-loaded bioadhesive nanoparticles (IDB/BNPs). (B) IDB/NNPs, IDB/BNPs, and IDB/Tris-BNPs were applied onto normal skin without microneedles. (C) IDB/NNPs, IDB/BNPs, and IDB/Tris-BNPs were applied onto normal skin via microneedles. | PMC10295737 | biomedicines-11-01649-g001.jpg |
0.441385 | 8228748fb0074b08ab4ba92d61e8dade | In vitro evaluation of nanoparticles. (A) Hydrodynamic diameter size distribution of different nanoparticle formulations. (B) Zeta potential of IDB/NNPs, IDB/BNPs, and IDB/Tris-BNPs. (C) Transmission electron microscopy (TEM) images of IDB/NNPs, IDB/BNPs, and IDB/Tris-BNPs. (Scale bars = 200 nm) (D) Drug release rate (%) of IDB/NNPs, IDB/BNPs, and IDB/Tris-BNPs at 37 °C. All experiments were carried out in triplicate. Data are shown as mean ± s.d. | PMC10295737 | biomedicines-11-01649-g002.jpg |
0.482485 | 7b83642d761b454a904317554d9f488c | Cell viability of NIH/3T3, B16F10, and HaCaT cells incubated with IDB/NNPs, IDB/BNPs, IDB/Tris BNPs, free IDB, blank NNPs, blank BNPs, and blank Tris BNPs for 24 h. (A,C,E) The cell viability of NIH/3T3, B16F10, and HaCaT cells treated with IDB (0.5 to 10 µg/mL)-loaded NPs was assessed using a Cell Counting Kit (CCK)-8 assay. (B,D,F) The cell viability of NIH/3T3, B16F10, and HaCaT cells treated with blank NNPs, BNPs, and Tris BNPs (5 to 100 µg/mL) was measured using the CCK-8 assay. All experiments were carried out in triplicate. Data are expressed as mean ± s.d. | PMC10295737 | biomedicines-11-01649-g003.jpg |
0.467821 | 01396b67c8b249f1bc5fdfcdb83b5611 | Effect of various NPs on melanogenesis in alpha-melanocyte-stimulating hormone (ɑ-MSH)-stimulated B16F10 cells. All experiments were carried out in triplicate. Data are expressed as mean ± s.d. * p < 0.05, *** p < 0.001. | PMC10295737 | biomedicines-11-01649-g004.jpg |
0.394016 | 3b21d5cded39455d9c59d28e012aae78 | Evaluation of Tris-BNPs adhesion and penetration with or without microneedle-mediated topical administration in healthy C57BL/6 mice. (A) NNPs, BNPs, and Tris-BNPs loaded with PLA-Cy5 at 1.0 mg/mL were topically applied to healthy C57BL/6 mice, without the use of microneedles. (B) The fluorescence intensity of mice skin without microneedle-mediated topical administration was quantified in each group. All experiments were carried out in triplicate. Data are expressed as mean ± s.d. (C) NNPs, BNPs, and Tris-BNPs at 1.0 mg/mL were administered to the healthy skin of C57BL/6 mice using microneedles. (Scale bars = 50 μm) (D) The fluorescence intensity of mice skin was quantified in each group. All experiments were carried out in triplicate. Data are expressed as mean ± s.d. *** p < 0.001. | PMC10295737 | biomedicines-11-01649-g005.jpg |
0.399426 | dfd7037995b545459bdda5b529869800 | Evaluation of NP retention. (A) NNPs, BNPs, and Tris-BNPs encapsulating PLA-Cy5 were applied on the normal skin of C57BL/6 mice with microneedles. The fluorescence signal retention was imaged with Xenogen at different time points. (B) The fluorescence intensity was quantified and normalized to the baseline intensity in each group. All experiments were carried out in triplicate. Data are expressed as mean ± s.d. * p < 0.05, ** p < 0.01, *** p < 0.001. | PMC10295737 | biomedicines-11-01649-g006.jpg |
0.457885 | 2126462970774046b42e74a888329a74 | Skin protection effect of NPs administered with microneedles to C57BL/6 mice skin after UV irradiation. (A) The changes in chroma values between day 1 and day 4 in each group. (B) The melanin content (%) on day 4 in each group. Statistical differences were compared with the non-UV control group. (C) The ROS content (%) on day 4 in each group. Statistical differences were compared with the non-UV control group. (D) The AGEs content (%) on day 4 in each group. Statistical differences were compared with the non-UV control group. Data are expressed as mean ± s.d. (n = 3). * p < 0.05, ** p < 0.01, and **** p < 0.0001. | PMC10295737 | biomedicines-11-01649-g007.jpg |
0.423772 | 2b76c8975a4142779031f5cc3c5db7a5 | In vivo toxicity evaluation. Hematoxylin and eosin (H&E) staining images of major organs of C57BL/6 mice on day 4 after various NP treatments. CP, commercial product (Scale bar = 100 µm). | PMC10295737 | biomedicines-11-01649-g008.jpg |
0.401118 | 65070ef9e09c48d1812acb4151f8b783 | Initial brain magnetic resonance imaging, contrast-enhanced CT of the chest and abdomen, and follow-up brain CT before and after VP shunt insertion(A) Brain diffusion-weighted magnetic resonance imaging shows diffusion restriction in both lateral ventricles and multifocal foci, which are indicative of septic encephalitis with pyoventriculitis. (B) Contrast-enhanced CT of the chest shows numerous, variably sized nodules and ill-defined peribronchial consolidation (arrowheads) in both lung fields. (C) Contrast-enhanced CT of the abdomen shows multiple small hepatic cysts (arrowheads) suggestive of necrotizing solid lesions. (D) Contrast-enhanced CT of the pelvis shows prominent enhancement in the prostate. (E) Brain CT before VP shunt insertion shows hydrocephalus of the lateral and 3rd ventricles with interstitial edema. (F) Brain CT shows decreased dilatation of the lateral and 3rd ventricles after VP shunt operation.CT, computed tomography; VP, ventriculoperitoneal. | PMC10295916 | encephalitis-2022-00010f1.jpg |
0.449547 | 8538093b990b4c24b3588a9169758174 | Transversal section of the rostral midbrain at the level of the red nucleus. Arrows indicate the location of the superior colliculi. CA: cerebral aqueduct; CP: cerebral peduncle; OMN: oculomotor nucleus; OCn: oculomotor nerve; PAG: periaqueductal gray; RN: red nucleus; SC: superior colliculus; SL: spinal lemniscus; SN: substantia nigra. Top right: brainstem diagram with indication of the location of the midbrain in the brainstem. Klüver–Barrera staining. Scale bar 1000 μm. | PMC10295940 | biomedicines-11-01689-g001.jpg |
0.442675 | d9ee918dac1a437982154ab067fec064 | Cytoarchitectural laminar organization of the SC in the infant. The superficial layers consist of in order from the outside: the stratum zonale (SZ), the stratum griseum superficialis (SGS) and the stratum opticum (SO). The deep layers consist of: the stratum griseum intermedium (SGI), the stratum album intermedium (SAI), the stratum griseum profundum (SGP) and the stratum album profundum (SAP). PAG: periaqueductal gray. Klüver–Barrera staining. Scale bar 200 μm. | PMC10295940 | biomedicines-11-01689-g002.jpg |
0.434769 | af37151f0a0d47f982768bcd213ca357 | SIDS-related changes in cell lamination. (A) normal structure of the SC in a control case (male, 4 months); (B) a considerable number of polygonal cells invading the superior layers in a SIDS case (male, 4 months). Arrows indicate some of these neurons. Klüver–Barrera staining. Scale bar 100 μm. | PMC10295940 | biomedicines-11-01689-g003.jpg |
0.447019 | 3022c079951d496e9dad44ae515dc670 | SIDS-related changes in myelin staining. (A) normal structure of the SC in a control case (female, 4 months); (B) a significant increase in the degree of myelin staining of the neuronal processes in the SGS, SGI and SGP in a SIDS case (male, 4 months). Klüver–Barrera staining. Scale bar 100 μm. | PMC10295940 | biomedicines-11-01689-g004.jpg |
0.497459 | d940cacc8b5e44fea74cac70b7e7da3e | Kaplan–Meier survival estimates of ICU survival according to RABs use. Abbreviations: ACEis: angiotensin-converting enzyme inhibitors; ARBs: angiotensin-receptor blockers; ICU: intensive care unit; RABs: renin-angiotensin system blockers. | PMC10296067 | cancers-15-03183-g001.jpg |
0.439402 | 1dafda14d7404f15bbb3458f9c2f93d3 | Independent determinants of in-ICU, in-hospital, and one-year mortality. Panel (A) Independent risk factors for in-ICU mortality. Panel (B) Independent risk factors for in-hospital mortality. Panel (C) Independent risk factors for one-year mortality. Abbreviations: ACEis: angiotensin-converting enzyme inhibitors; ARBs: angiotensin-receptor blockers; CI: confidence interval; DFLSTs: decisions to forgo life-sustaining therapies; ICU: intensive care unit; OR: Odds Ratio; SAPS II: Simplified Acute Physiology Score II. | PMC10296067 | cancers-15-03183-g002.jpg |
0.448912 | b34e3d6d13874961a4c1d8ecf48fb43f | Kaplan–Meier survival estimates of one-year survival according to ARBs use after propensity score matching. Abbreviations: ARBs: angiotensin-receptor blockers; RABs: renin-angiotensin system blockers. | PMC10296067 | cancers-15-03183-g003.jpg |
0.429775 | 0e87869bdf2c48e599f56119a2c45978 | Results of the one significant latent variable from the PLS analysis with both T1 and MD values. (Panel A) Correlations of brain scores with behavior (± 95% confidence interval, CI). This latent variable identified similar and stable correlations in cisgender boys (CBs) and GD AFAB individuals (GDs) which were stable for age (CB-a; GD-a) and degree of androphilia-gynephilia (CB-deg; GD-deg) in both groups and for strength of sexual attractions in the CBs (CB-str). No correlations were stable in the cisgender girls (CG-str, CG-deg, CG-a). Scatterplots of brain scores by behavioral measures for all participants can be found in Figure S4 (Supplementary Material). (Panel B) Brain saliences for all ROIs for T1 and MD. The majority of brain saliences were negative, indicating that in cisgender boys and GD AFAB individuals, shorter T1s and slower MDs (one region) correlated with older age and stronger gynephilia, and in cisgender boys only, stronger attractions. For the remainder of the stable MD regions, a faster MD value correlated with age and sexual orientation in cisgender boys and GD AFAB individuals. (Panel C) Surface projection of stable ROIs: green = T1 relaxation time only, blue = MD only, purple = MD and T1; created with BrainNet Viewer (version 1.7, Beijing; https://www.nitrc.org/projects/bnv/) [53]. L = left; R = right. | PMC10296103 | brainsci-13-00963-g001.jpg |
0.467111 | 9fb43a1dbdc54b3aba88b0fd6380e4f4 | A multi-component account of developmental coordination disorder (DCD) (adjusted from Blank et al. [2]). IMD: internal modelling deficit; EF: executive function. | PMC10296699 | brainsci-13-00940-g001.jpg |
0.424739 | 90520a4a3827493d87310fa20342ab88 | Overview of the proposed method for automatic detection of respiratory events. | PMC10296791 | entropy-25-00879-g001.jpg |
0.51126 | b3b9ad1b070140fc894e10a1ddeace0b | The distribution of some ECG-related features in different respiratory events. (a) Triangular index of RR interval. (b) SD1/SD2 parameters of RR interval scatter plot. (c) Shannon entropy based on RR interval. (d) Ratio of low and high frequency power from cardiopulmonary coupling analysis. | PMC10296791 | entropy-25-00879-g002.jpg |
0.453189 | 0d736858f5fa4cbab205f886cecbf6a8 | Confusion matrix of different classifiers. (a–c) Confusion matrix of DT, RF and XGBoost based on oronasal airflow-related features. (d–f) Confusion matrix of DT, RF and XGBoost based on ECG-related features. (g–i) Confusion matrix of DT, RF and XGBoost based on oronasal airflow and ECG features. | PMC10296791 | entropy-25-00879-g003.jpg |
0.450063 | 1797c5477bc54d4ebe5fd43ec2758612 | The impact of single features on the output of the XGBoost model. (a–c) The SHAP value for respiratory frequency for the conditions of normal breathing, hypopnea and apnea, respectively. (d–f) The SHAP value for the total power normalized in the frequency domain of the HRV analysis for the conditions of normal breathing, hypopnea and apnea, respectively. (g–i) The SHAP value for the SD1 parameter for the conditions of normal breathing, hypopnea and apnea, respectively. | PMC10296791 | entropy-25-00879-g004.jpg |
0.435617 | ced77f458bc24e2db6ceef10933a7a99 | Frequency plots of the duration distribution. (a) Obstructive sleep apnea, (b) central sleep apnea. | PMC10296791 | entropy-25-00879-g005.jpg |
0.426465 | 9106ef2949ae450ea7e2ff13e5ccb887 | Distribution states of fusion signals in different respiratory events. | PMC10296791 | entropy-25-00879-g006.jpg |
0.455469 | 4742aae72fa248ddb0a7204dba5d6e6c | Confusion matrix and ROC curve for LSTM model. (a) Confusion matrix of the LSTM model. (b) ROC curves of the LSTM model. | PMC10296791 | entropy-25-00879-g007.jpg |
0.472474 | 5bf266162d0c4a5e975839a77b856f25 | Bezafibrate (BEZ) post-treatment mitigates sulfite-induced decrease in MBP and increase in NG2 staining in rat striatum 7 days after sulfite injection (2 μmol). Animals were post-treated with BEZ [30 (A) or 100 (B) mg/kg/day] for 7 days after sulfite infusion. n = 3–4. * p < 0.05, compared to rats receiving NaCl (2 μmol) (control group); ## p < 0.01, compared to rats receiving sulfite (sulfite group) (ANOVA followed by Duncan multiple range test). | PMC10296939 | cells-12-01557-g001.jpg |
0.381995 | 615a042b621245d69fa58d6542bfa609 | Bezafibrate (BEZ) post-treatment mitigates sulfite-induced decrease in the viability of MO3.13 cells. Cells were incubated with sulfite (500 μM) for 24 or 48 h (A,B). In further experiments, cells were post-treated with BEZ (200 or 1000 nM) for 6 h (C). n = 6–8. * p < 0.05, *** p < 0.001, compared to control group; ## p < 0.01, compared to sulfite group (ANOVA followed by Duncan multiple range test). | PMC10296939 | cells-12-01557-g002.jpg |
0.447897 | 84ca193cedac48d781ab5973687f37c1 | Bezafibrate (BEZ) post-treatment mitigates sulfite-induced increase in Iba1 staining in rat striatum 7 days after sulfite injection (2 μmol). Animals were post-treated with BEZ (30 or 100 mg/kg/day) for 7 days after sulfite infusion. n = 3. * p < 0.05, compared to rats receiving NaCl (2 μmol) (control group); # p < 0.05, compared to rats receiving sulfite (sulfite group) (ANOVA followed by Duncan multiple range test). | PMC10296939 | cells-12-01557-g003.jpg |
0.448337 | f339b517e08645ad9de05c0bc3f2cdad | Alterations on the expression of IL-6 (A), IL-1β (B), IL-10 (C), TNF-α (D), ILR1 (E), TNFR1 (F), NFκB (G) and COX-2 (H) elicited by bezafibrate (BEZ) post-treatment and sulfite in rat striatum 7 days after sulfite injection (2 μmol). Animals were post-treated with BEZ (30 or 100 mg/kg/day) for 7 days after sulfite infusion. n = 5. * p < 0.05, ** p < 0.01, *** p < 0.001, compared to rats receiving NaCl (2 μmol) (control group); ## p < 0.01, ### p < 0.001, compared to rats receiving sulfite (sulfite group) (ANOVA followed by Duncan multiple range test). | PMC10296939 | cells-12-01557-g004.jpg |
0.482846 | a9b524b20c8c4dbdb8a2dcf952756661 | Alterations on the expression of iNOS (A), Nrf2 (B), HO-1 (C), SOD1 (D) and SOD2 (E) elicited by bezafibrate (BEZ) post-treatment and sulfite in rat striatum 7 days after sulfite injection (2 μmol). Animals were post-treated with BEZ (30 or 100 mg/kg/day) for 7 days after sulfite infusion. n = 5. *** p < 0.001, compared to rats receiving NaCl (2 μmol) (control group); ### p < 0.001, compared to rats receiving sulfite (sulfite group) (ANOVA followed by Duncan multiple range test). | PMC10296939 | cells-12-01557-g005.jpg |
0.433587 | 9c7d470c01aa412e9b06c19f4c5bffeb | Bezafibrate (BEZ) pre-treatment mitigates sulfite-induced alterations on MBP and Iba1 staining in rat striatum, and reduction in the viability of MO3.13 cells. Animals were pre-treated with BEZ (30 or 100 mg/kg/day) for 7 days after sulfite infusion (A,C). In MO3.13 cells, pre-treatment with BEZ (200 or 1000 nM) was for 6 h (B). n = 3–6. * p < 0.05, ** p < 0.01, *** p < 0.001, compared to rats receiving NaCl (2 μmol) (control group); ## p < 0.01, ### p < 0.001, compared to rats receiving sulfite (sulfite group) (ANOVA followed by Duncan multiple range test). | PMC10296939 | cells-12-01557-g006.jpg |
0.51245 | dbc53a49e86343ba8d3e13382250c9e0 | Schematic representation of PRISMA workflow for manuscripts’ selection. | PMC10296945 | diagnostics-13-02009-g001.jpg |
0.455546 | eb559ad37f1e4e9e990c889d3cae8049 | Quality appraisal of selected articles using CASP checklist for diagnostic studies [14,15,16,17,18,19,20,21,22,23]. | PMC10296945 | diagnostics-13-02009-g002.jpg |
0.39033 | 178065f58bfb43b79d9a9fcb481cd5d3 | 60-year-old male. Pathological fracture in C6. Bone marrow biopsy was compatible with multiple myeloma. (upper row) Baseline FDG PET/MR demonstrated the presence of multiple focal uptake in the bones, without extranodal involvement, corresponding to an increase of signal at DWI images. After induction chemotherapy (lower row), FDG PET/MR demonstrated no uptake in the site of pre-existing lesions, with the persistence of a slight signal at DWI images. Therefore, FDG–PET was conclusive for the presence of non-viable tissue. | PMC10296945 | diagnostics-13-02009-g003.jpg |
0.394818 | 63283f285e9a487883130fb4bcd0f31b | Isolation of proso millet starch. | PMC10297480 | foods-12-02413-g001.jpg |
0.45384 | bd8bca8a2fa645cfb67da28e8e4f79e4 | Focal pancreatic parenchymal atrophy (FPPA). T2 magnetic resonance imaging shows that the pancreatic parenchyma is lacking with an irregular shape and is replaced by fat (square arrow) near the cystic lesion (arrow). | PMC10297586 | diagnostics-13-02080-g001.jpg |
0.403727 | 957077797998483db5be8c34fb9a7a3e | Histopathology of focal pancreatic parenchymal atrophy (FPPA). (a) FPPA consists of replaced adipose tissue. The margin of the area is sharp and clear, and the surrounding pancreatic parenchyma shows no significant changes, such as inflammatory cell infiltration, fibrosis, or atrophy (hematoxylin–eosin, ×40). (b) FPPA is observed around or adjacent to the pancreatic duct with neoplastic changes in the pancreatic ductal epithelium (square part of a) (hematoxylin–eosin, ×200). | PMC10297586 | diagnostics-13-02080-g002.jpg |
0.471796 | 0e863defcf5c44f8b1777027078da028 | Endoscopic ultrasonography (EUS) finding of focal pancreatic parenchymal atrophy (FPPA). FPPA can be observed on EUS as a blurred hypoechoic area (arrow). | PMC10297586 | diagnostics-13-02080-g003.jpg |
0.465046 | 176e6485bc894353871082db86f7b5fa | Endoscopic nasopancreatic drainage tube (arrow) placement for serial pancreatic juice aspiration cytologic examination (SPACE). | PMC10297586 | diagnostics-13-02080-g004.jpg |
0.486823 | f144bd49807b4137b72a9c8a4b3e6610 | Proposal of a diagnostic strategy for pancreatic cancer at the early stage. Endoscopic ultrasound (EUS) is the first-line treatment for patients at risk of pancreatic ductal adenocarcinoma (PDAC). Endoscopic ultrasound-guided fine-needle aspiration (FNA) is performed when a tumor is identified. If a histopathological finding of PDAC is not obtained despite repeated EUS-FNA, serial pancreatic juice aspiration cytologic examination (SPACE) is undertaken. If no tumor is detected on EUS, but focal pancreatic parenchymal atrophy (FPPA) is recognized on magnetic resonance imaging (MRI) or computed tomography (CT), SPACE is selected. PDAC, pancreatic ductal adenocarcinoma; EUS, endoscopic ultrasonography; EUS-FNA, EUS-guided fine-needle aspiration; MRI, magnetic resonance imaging; CT, computed tomography; FPPA, focal pancreatic parenchymal atrophy; SPACE, serial pancreatic juice aspiration cytologic examination. | PMC10297586 | diagnostics-13-02080-g005.jpg |
0.50167 | 2714a7b0c1584ec2a9f2297c1efa6cc2 | Prisma flowchart over study selection [13]. | PMC10298745 | ijerph-20-06069-g001.jpg |
0.403479 | 129c730d5792450096c8693f584f6243 | Risk of GDM after exercise intervention during pregnancy. Explanation: 95% CI−95% confidence interval. The forest plot shows the crude risk of GDM after exercise. Relative risk <1 favors exercise, whereas relative risk > 1 favors control intervention. I2−inconsistency; τ2−between-study variance. Treatment−intervention group. Yes—refers to all cases with GDM; no−refers to the cases without GDM [12,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38]. | PMC10298745 | ijerph-20-06069-g002.jpg |
0.434704 | e7251bae5ca0429aac80790678981796 | Relation between covariates and the risk of GDM. Explanation: 95% CI−95% confidence interval. The size of the bubbles represents the precision of the studies, the bigger the bubble, the higher the precision. GDM—gestational diabetes mellitus. | PMC10298745 | ijerph-20-06069-g003.jpg |
0.535517 | e0072e55b1cf450fb4e27b3577e58d2a | Risk of preeclampsia after exercise intervention during pregnancy. Explanation: 95% CI—95% confidence interval. The forest plot shows the crude risk of preeclampsia after exercise. Relative risk <1 favors exercise, whereas relative risk >1 favors control intervention. I2−inconsistency; τ2−between-study variance. Treatment−intervention group. Yes−refers to all cases with preeclampsia; no−refers to the cases without preeclampsia [22,24,25,28,31,34,36,38,39]. | PMC10298745 | ijerph-20-06069-g004.jpg |
0.484842 | 00604ddcab734d7ab22a69b92da9039d | Risk of withdrawal after exercise intervention compared to control group during pregnancy. Explanation: 95% CI−95% confidence interval. The forest plot shows the crude risk of withdrawal after exercise. Relative risk <1 favors exercise, whereas relative risk >1 favors control intervention. I2—inconsistency; τ2—between-study variance. Treatment—intervention group. Yes—refers to all cases with withdrawal; no—refers to the cases without withdrawal [12,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40]. | PMC10298745 | ijerph-20-06069-g005.jpg |
0.459349 | 770a5994da564ea58b57c443973161c9 | Funnel plot for GDM with pseudo 95% confidence interval. | PMC10298745 | ijerph-20-06069-g0A1.jpg |
0.441922 | 42ffeeeb773549458de129f86340ff15 | Funnel plot for preeclampsia with pseudo 95% confidence interval. | PMC10298745 | ijerph-20-06069-g0A2.jpg |
0.427749 | d3a6983b833544188dbe378f378d32f2 | Risk of GDM after exercise intervention during pregnancy by subgroup interventions modality. Explanation: 95% CI—95% confidence interval. The forest plot shows the crude risk of GDM after exercise intervention during pregnancy by subgroup interventions modality. Relative risk <1 favors exercise, whereas relative risk > 1 favors control intervention. I2—inconsistency; τ2—between-study variance [12,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,40]. | PMC10298745 | ijerph-20-06069-g0A3.jpg |
0.361683 | fe7df0af69ee44b9b11b1520b3b463b9 | Risk of GDM after exercise intervention during pregnancy by subgroup supervised sessions/mixed sessions. Explanation: 95% CI—95% confidence interval. The forest plot shows the crude risk of GDM after exercise intervention during pregnancy by subgroup supervised sessions/mixed sessions. Relative risk <1 favors exercise, whereas relative risk >1 favors control intervention. I2—inconsistency; τ2—between-study variance [12,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,40]. | PMC10298745 | ijerph-20-06069-g0A4.jpg |
0.407975 | 1cbeda89e9df49eca1b90c0a7657ea4a | Risk of GDM after exercise intervention during pregnancy by subgroup intensity [12,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,40]. | PMC10298745 | ijerph-20-06069-g0A5.jpg |
0.372941 | 2b0fd750d1084770b09fe72131dc42d3 | Risk of preeclampsia after exercise intervention during pregnancy by subgroup interventions modality. Explanation: 95% CI—95% confidence interval. The forest plot shows the crude risk of preeclampsia after exercise intervention during pregnancy by subgroup interventions modality. Relative risk <1 favors exercise, whereas relative risk >1 favors control intervention. I2—inconsistency; τ2—between-study variance [12,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,40]. | PMC10298745 | ijerph-20-06069-g0A6.jpg |
0.420832 | 1e9be0d1c03b485db682d91e709719dd | Risk of preeclampsia after exercise intervention during pregnancy by subgroup supervised, non-supervised, or mixed intervention. Explanation: 95% CI—95% confidence interval. The forest plot shows the crude risk of preeclampsia after exercise intervention during pregnancy by subgroup supervised, non-supervised, or mixed intervention. Relative risk <1 favors exercise, whereas relative risk >1 favors control intervention. I2—inconsistency; τ2—between-study variance [22,24,25,28,31,34,36,38,39]. | PMC10298745 | ijerph-20-06069-g0A7.jpg |
0.410466 | 2d6cc1192e23436181611721f6d7f280 | Risk of preeclampsia after exercise intervention during pregnancy by subgroup intensity of intervention. Explanation: 95% CI—95% confidence interval. The forest plot shows the crude risk of preeclampsia after exercise intervention during pregnancy by subgroup intensity of intervention. Relative risk <1 favors exercise, whereas relative risk >1 favors control intervention. I2—inconsistency; τ2—between-study variance. Definition of less extensive and moderate: Moderate extensive: 12–24 sessions; 30–60 min/session; 1–2×/week; AE: 50–70% of HRM, VO2 max or HRR; RE: 50–70% of 1RM. Less extensive: <12 sessions; ≤1×/week; ≤30 min/session; AE: ≤50% of HRM, VO2 max, HRR; RE: ≤50% of 1 RM [22,24,25,28,31,34,36,38,39]. | PMC10298745 | ijerph-20-06069-g0A8.jpg |
0.415327 | e0750726e51c4d52a244e708e2cba4fe | Schematic of transfection of pigs using pCAGG-EGFP plasmid, electrical fusion/activation, and propagation of transgenic strain. Created with BioRender.com (accessed 28 March 2022). | PMC10299052 | jcdd-10-00254-g001.jpg |
0.450915 | b5dd30ebed174e33924c0435d907c753 | Immunofluorescence images of the aorta (Ao), pulmonary artery (PA), aortic valve (AV), and pulmonary valve (PV) of green fluorescent protein-transgenic (GFP-Tg) and wild-type (WT) pig tissues stained for GFP (green) and nuclear staining (DAPI; blue). Scale bar = 100 μm. | PMC10299052 | jcdd-10-00254-g002.jpg |
0.391733 | 97b951fd9ba643c9bccb6f1952ecf17d | Areas of colocalization over areas of DAPI were measured for green fluorescent protein (GFP) vs. wild-type (WT) in the aorta (Ao), pulmonary artery (PA), aortic valve (AV), and pulmonary valve (PV). GFP-transgenic (GFP-Tg) cardiac tissue expressed GFP at a statistically significantly higher level than WT cardiac tissue in all four tissues (Ao, p = 0.0002; PA, p = 0.0005; AV and PV, p < 0.0001). Mann–Whitney statistical test. | PMC10299052 | jcdd-10-00254-g003.jpg |
0.396596 | 509e909860cc4d8daae95c1d739edfd0 | Scatter plot showing orthogroups expanded in trees and herbaceous plants. Numbers in square brackets associated with circle sizes stand for -log(p-adjust), where p-adjust is the p-value of the binomial test adjusted for multiple testing (Figure 4b in [4]). | PMC10299211 | ijms-24-10403-g001.jpg |
0.410515 | 846359043f1341c5b12bde7f4e5cc507 | Schematic representation of the balance between aging and growth. The blue, red and green boxes represent decreased, increased and invariant index values in old trees, respectively. (A) Balance diagram; the balance between growth and aging is maintained by decreased cambium activity. (B,C) Old G. biloba trees lack senescence symptoms. (D) Resistance mechanisms delay senescence in old trees. The color gradation shows the values of indices. (E) Variation in growth rate, senescence symptoms and the resistance ability with age (modified Figure 7 in [3]). | PMC10299211 | ijms-24-10403-g002.jpg |
0.523842 | bf953f71eefb4ae4be60c6e95acea3f6 | Evolutionarily significant biological processes responsible for Ficus longevity (modified Figure 3 in [9]). | PMC10299211 | ijms-24-10403-g003.jpg |
0.466745 | ca37d018220b4aa9bd4b9c39ce51d7fb | Adaptive evolution of genes involved in regulating senescence in Ficus benghalensis (A) and F. religiosa (B) (Figure 4C,D in [9]). | PMC10299211 | ijms-24-10403-g004.jpg |
0.443352 | d3c7000a3848450bbae787f6fdefde22 | Schematic model showing the adaptation mechanisms underlying aging. (a) Dynamic patterns of some essential biological pathways underlying aging. (b) Proposed model for selection of Actinobacteria lineages during the development of poplar in the root-associated microbiome. (1) Early random trial of specific microbiome. (2) Altered metabolism positively selects for Actinobacteria. (3) Recruitment of the lineage of Actinobacteria. Dashed arrows indicate biological processes in the model and non-dashed arrows indicate regulating pathways between plant and microbiome (modified Figure 6 in [13]). | PMC10299211 | ijms-24-10403-g005.jpg |
0.471641 | b83920022eb9478fab532931c6e82f23 | Diagrammatic representation of KNOTTED-like homeobox Class 1 (KNOX 1) and ASYMMETRIC LEAVES1/ROUGHSHEATH2/PHANTASTICA (ARP) gene expression in a typical plant with determinate leaf growth (left) and in Welwitschia (right). With determinate leaf growth, there is an antagonistic regulation of KNOX 1 and ARP, which does not occur in Welwitschia, resulting in indeterminate leaf growth (SAM = shoot apical meristem, LP = leaf primordia) (Figure 4b in [14]). | PMC10299211 | ijms-24-10403-g006.jpg |
0.427853 | 619df903063845ed9959e8fec5908c52 | Weighted gene co-expression network analysis (WGCNA) revealed expression differences between basal meristems and young leaf material. The number of genes in each GO term enrichment category at each node are shown by the circle size. p-values are based on Fisher’s exact test, with two-sided and false discovery rate correction used for calculating p values. The probability that the node contains gene(s) that control differential gene expression between tissues is depicted by node color. The lines connecting each node indicate correlated gene expression between genes (Figure 4e in [14]). | PMC10299211 | ijms-24-10403-g007.jpg |
0.503776 | 24b614819b0b4528ad980914ce68a04f | DNA methylation dynamics associated with the age timer DAL1 age-related expression. (a) The DNA methylation patterns of the PtDAL1 gene in four age stages. (b) The expression of PtDAL1 at 2, 5, 14 and 35 years. Data were presented as means ± SD of three biological replicates. (c) Age-related CHG demethylation of PtDAL1 (Figure 5 in [19]). | PMC10299211 | ijms-24-10403-g008.jpg |
0.461013 | 3af51b60f21d46508b9e3fd290e9deab | Expression changes of nine key SOC1-like transcription factors in the age-related gene module as the age increased. The data are presented as the means ± SD of three biological replicates, which values depicted as dots (Supplementary Figure 17 in [19]). | PMC10299211 | ijms-24-10403-g009.jpg |
0.448027 | 4d96f11f9df64d72837483d15df38b65 | The resin terpene biosynthesis pathways in Pinus tabuliformis. The gene numbers of P. tabuliformis (green box), Picea glauca (blue box) and Arabidopsis thaliana (orange box) in the mevalonate (MEV) and methylerythritol phosphate (MEP) pathways. A five-point star represents the rate-limiting steps of isoprenoid biosynthesis. An asterisk denotes the genes that were duplicated in P. tabuliformis. AACT, acetyl-CoA acetyltransferase; HMGS, hydroxy methylglutaryl-CoA synthase; HMGR, hydroxy methylglutaryl-CoA reductase; MK, mevalonate kinase; PMK, phosphomevalonate kinase; MDD, diphosphomevalonate decarboxylase; DXS, 1-deoxy-d-xylulose-5-phosphate synthase; DXR, 1-deoxy-d-xylulose-5-phosphate reductoisomerase; MCT, 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; CMK, 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; MDS, 2-C-methyl-D-erythritol 2, 4-cyclodiphosphate synthase; HDS, 2-C-methyl-D-erythritol 2, 4-cyclodiphosphate synthase; HDR, 2-C-methyl-D-erythritol 2, 4-cyclodiphosphate reductase; IPPI, isopentenyl-diphosphate delta-isomerase; GPPS, geranyl diphosphate synthase; FPPS, farnesyl pyrophosphate synthase; GGPPS, geranylgeranyl diphosphate synthase; TPS, terpenoids synthase; CYP450, cytochrome P450 (modified Figure 3A in [23]). | PMC10299211 | ijms-24-10403-g010.jpg |
0.497497 | 84f408ae1cf44253b6cc06bea771319b | Expression patterns of the LaAGL2-1 (a), LaAGL2-2 (b), LaAGL2-3 (b), LaSOC1-1 (c), LaAGL11 (d) and LaAP2-2 (e) genes of Larix kaempferi in 3-month-old grafted seedlings (n = 6, sampled in 2019) and 1- and 13-year-old seed seedlings (n = 11, sampled in 2019) assayed using qRT-PCR with LaFBP1 as the internal control (Figure 7 in [25]). | PMC10299211 | ijms-24-10403-g011.jpg |
0.423047 | e730c2c4538149d8895d5aa54b05e7b7 | The relationships between growth rate and copy number ratio of PARP1 in 11 tree species (Figure 5 in [26]). | PMC10299211 | ijms-24-10403-g012.jpg |
0.450421 | 73fc54ed2fb44acf922483500bdf5456 | A general scheme for discovering genetic traits associated with the PARP gene family and plant longevity (graphical abstract in [26]). | PMC10299211 | ijms-24-10403-g013.jpg |
0.382899 | 58c26f7bc5f64a80b85200673576bd46 | Stem cells in plants (Figure 1 in [32]). (A) Schematic of a longitudinal section of the shoot apical meristem (SAM) in Arabidopsis. The SAM consists of three developmental zones: (i) the central zone (CZ; red), with a population of slowly dividing stem cells; (ii) the surrounding peripheral zone (yellow), where cells divide rapidly to give rise to lateral organs, and (iii) the rib zone (green), where cells differentiate into central stem tissue. (B) Schematic of a longitudinal section of the root apical meristem (RAM) in Arabidopsis. The RAM consists of a small group of cells that form the quiescent center (QC; blue) and is surrounded by stem cells (red). Signals from the QC maintain the stem cell niche of the surrounding stem cells. (C) Schematic of a cross-section through the Arabidopsis inflorescence stem. The vascular cambium meristem (VCM) is shown in red. The vascular cambium generates the xylem (yellow) and phloem (blue) through inward and outward cell division, respectively. | PMC10299211 | ijms-24-10403-g014.jpg |
0.460485 | 37dc099af8674431a6bf76c0f485b126 | (A) Optical microscopy of CMC cells. Bar: 10 µm. (B–H) Flow cytometry analysis of subconfluent cultures. IgG control (grey peak); target protein (black peak). Data were normalized to the peak height (number of events), resulting in relative percentages (%) ± standard deviation (SD). The analysis was performed using FlowJo™ v10.8.1 Software (Ashland, OR, USA). | PMC10299282 | ijms-24-10397-g001.jpg |
0.453499 | 9b3235fd514b413b8b6df402644e795f | Cell viability analysis on CMCs pretreated with TNFα (10 ng/mL) for 3 h and then stimulated for a further 24 h with DCF001 (1 µg/mL) in a proliferative (A) or chondrogenic (B) medium. Data were expressed as a percentage (%) ± SD of viable cells detected using cell counting with the trypan blue exclusion of dead cells. In parallel, extracellular ATP (eATP) in PM (C) and CM (D) cultures was evaluated using the CellTiter-Glo® Luminescent Cell Viability Assay. Luminescence was read with a VICTOR® Nivo™ Plate Reader (PerkinElmer, Waltham, MA, USA) and then reported in relative light units (RLU). * p: vs. control; ° p: vs. DCF001-induced cells; ^ p: vs. TNFα-primed cells. | PMC10299282 | ijms-24-10397-g002.jpg |
0.493889 | 4acd2f7d7cff4a5c9d470cc19300e46c | Detection of CD39 (A,C) and CD73 (B,D) expression in CMC cells. The samples were pretreated with TNFα (10 μg/mL) for 3 h and thus cultured for a further 24 h with a proliferative (PM) or chondrogenic (CM) medium supplemented with DCF001 (1 µg/mL). Unstimulated cells (control) or samples treated with only DCF001 or TNFα were used as references. The analysis was performed by flow cytometry using direct staining, and data were reported as representative histograms and relative MFI values (Rel. MFI = target MFI/Isotype IgG MFI). * p: vs. control; ^ p: vs. TNFα-primed cells. | PMC10299282 | ijms-24-10397-g003.jpg |
0.402405 | 8914582adfe240bda41a9a1457849dc9 | FCM analysis of TNFR1 and TNFR2 in CMC cells cultured in proliferative (PM) or chondrogenic (CM) medium or cells treated with only TNFα (10 μg/mL) and/or DCF001 (1 µg/mL). (+) Added to culture medium; (-) not added to culture medium. Histograms represent the basal expression of both TNFR1 and TNFR2 under PM and CM medium. Data from all experimental groups were reported in the table as the mean value of percent positive cells ±SEM. * p: vs. control in PM; ° p: vs. DCF001-induced cells in PM; ^ p: vs. TNFα-induced cells in CM. | PMC10299282 | ijms-24-10397-g004.jpg |
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