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0.452951 | 2dd9730d4c1e4038acdfa9a87b21974f | Phage expression in the presence and absence of the protist.A Pearson correlation of the phage gene expression values (as log2RPKM) with and without protist shows that phage expression levels are largely the same in both treatments. B Heatmap representing the expression (as standardized log2RPKM) of all phage genes (vertical) in the treatment with (right) or without (left) protists. Genes that change temporal dynamics in the presence of protists are marked in green (5 in total) and their annotations are displayed. The known transcriptional categories for this and generally the T4-like myophages (early, middle and late-expressed genes) are unaltered with protist for all except 5 genes (see Supplementary text). The time course for the infection captures more than one infection cycle: the first one with the phages added at the start of the experiment (“inf. cycle 1”) and the ones that follow once the phages are released from “inf. cycle 1” and infect new cells (“inf. cycle 2+”). | PMC9723779 | 43705_2022_169_Fig2_HTML.jpg |
0.48595 | fa233d94b29d40ab9d08f008fc753b27 | Host genes and metabolites altered in each treatment relative to the untreated control.A Number of intracellular metabolites detected as significantly changing in each of the treatments (Venn diagram) and their log10FC value in the treatment relative to the untreated cells (heatmap). Compound names are colored by the class to which they belong, and the confidence in their detection is indicated by an asterisk next to the name. Confidence of level 1 (1 asterisk) indicates the compound had three identification criteria in positive or negative mode (i.e., retention peak, mz, and msms), whereas level 2 (2 asterisks) denotes two of the three criteria were met. Compounds denoted as “Other” represent detected features that were not identified. B Number of host genes differentially expressed in response to protist only (“cyanobacteria with protist”), phage only (“cyanovirocells only”), or phage plus protist (“cyanovirocells with protist”) pictured in a Venn diagram as well as their heatmap, which denotes gene expression as log2fold change (FC) values in the treatment compared to the untreated control over the experiment time course. Gray heatmap cells denote genes or metabolites that did not significantly change their expression or abundance, respectively, in the treatment relative to the control. All represented data derive from the average of a minimum of three biological replicates in which the treatment was compared to the uninfected control (cells only, no phage, no protist). The time course for the cyanovirocells and cyanovirocells with protist captures more than one infection cycle: the first one with the phages added at the start of the experiment (“inf. cycle 1”) and the ones that follow once the phages are released from “inf. cycle 1” and infect new cells (“inf. cycle 2+”). | PMC9723779 | 43705_2022_169_Fig3_HTML.jpg |
0.475834 | 31e5f2d70f0247d6bcd51774326fafac | Cyanovirocell energy and resource metabolic pathways responding to the protist.A Photosynthesis and phosphate (P) stress. B Central C metabolism, including mannose synthesis, glycolysis, galactose metabolism pentose phosphate pathway (PPP), Calvin cycle, and the Tricarboxylic acid (TCA) cycle. C De novo purine and pyrimidine nucleotide synthesis. Phage auxiliary metabolic genes (AMGs) are in green text. Host over-expressed genes are in purple, while the under-expressed one is in red. The color of the arrow or the border (orange or blue) denotes if the gene is expressed in response to phage only or phage and protist. Metabolites that change significantly have a background shade colored red (if enriched) or yellow (if depleted) and the position of the shade denotes under which treatment they are altered: in the cyanovirocells only or in the cyanovirocells co-cultured with protists. D Photosynthetic efficiency of Synechococcus cells under each condition. Asterisks indicate when treatments are significantly different (t-test, p value <0.05). Cyanovirocells and cyanovirocells with protist both have significantly lower photosynthetic efficiency than uninfected cells (red and blue arrows with asterisks, respectively), but cells with just the protist do not (t-test, p value >0.05). Cyanovirocells with protist significantly increase in photosynthetic efficiency from ~2 to ~5 h post infection relative to cyanovirocells alone (t-test, p value <0.05). Abbreviations can be found in the Supplementary text. | PMC9723779 | 43705_2022_169_Fig4_HTML.jpg |
0.433309 | a056651e62504bc28fc4556456359a75 | Changes in the extracellular metabolome of cyanobacteria across three treatments.Venn diagram: number of significantly changing metabolites detected extracellularly in each treatment. Heatmap: abundance of all significantly changing metabolites detected extracellularly with each treatment, in log10-fold change (FC) of the values in the treatment relative to the uninfected control. The colored bar on the left represents the class to which the metabolites belong. The confidence in metabolite detection is indicated by an asterisk next to the name. Confidence of level 1 (1 asterisk) indicates that the compound met all three identification criteria in positive or negative mode (i.e., retention peak, mz, and msms), whereas level 2 (2 asterisks) denotes two of the three criteria were met. The time course for cyanovirocells and cyanovirocells with protist captures more than one infection cycle: the first one with the phages added at the start of the experiment (“inf. cycle 1”) and the ones that follow once the phages are released from “inf. cycle 1” and infect new cells (“inf. cycle 2+”). | PMC9723779 | 43705_2022_169_Fig5_HTML.jpg |
0.50995 | a03d6ddce2b44668b5c95287ef6d8af7 | Metabolic reprogramming and ecosystem impact of protist- and/or phage-treated Synechococcus.A Uninfected cyanobacterium. B Cyanobacteria with protist. The presence of the protist alters the abundance of some exometabolites. C Cyanovirocells only. Cyanophages reprogram P-acquisition, photosynthesis, energy pathways, and nucleotide metabolism toward building new phages. D Cyanovirocells with protist. The energy (e.g., ATP) and resource (e.g., reducing power, phosphate, nucleotides, and amino acids) demand of phage infection is highest for the cyanovirocells co-cultured with a protist. Cyanovirocells have the largest changes in the exometabolites as seen from the release of nutrients, either via diffusion or active transport across the membrane (C, D). This nutrient pool is available for the ecosystem, including uptake by protists (D). | PMC9723779 | 43705_2022_169_Fig6_HTML.jpg |
0.44402 | fddf1a4bb3034933b03ac471d894d9b3 | Pathogenesis of IgA nephropathy. Somatic factors and hereditary mutation trigger Abnormal Galactose-IgA1 formation by B-lymphocyte. Infection of mucosa and tonsils stimulates an abnormal immune system ± abnormal systemic response (Hit1). The increased abnormal def-galactose-IgA1 enhances abnormal glycosylated IgA antibody (Abnormal-Gal-IgA1-AB) (Hit 3). Then an immune-mediated complex (IMC) is formed between abnormal def-galactose-IgA1 and Abnormal-Gal-IgA1-AB (IgA1-antigen-IMC), which stimulates the formation of glycan-specific IgG and complex IgA-Antibodies (glycan-specific IgG and IgA-Abs). The glycan-specific IgG and IgA-Abs and locally produced interleukins (ILs) and other proinflammatories, profibrogenic factors, IMC deposit, damage the tubular epithelial cells, glomerular podocytes and mesangial (Hit 4). | PMC9726424 | medi-101-e31219-g001.jpg |
0.445421 | 258034ae31274210991daed860328f10 | Study design. Immune response to vaccination was assessed in a sample of 34 NH residents 6 and 12 months after the first SARS-CoV-2 vaccination (T6 and T12). A booster SARS-CoV-2 vaccine dose was administered to NH residents after blood sampling at T6. Mean follow-up time between booster dose and T12 assessment was 5 months. | PMC9726683 | fx1_lrg.jpg |
0.449155 | 60e5a6ec3b8d4229a716ac67ae34d2dd | T-cell mediated immune response in NH residents 6 months (pre-booster, T6) and 12 months (postbooster, T12) after first immunization. (A) Frequencies of CD4 and CD8 T cells producing IFN-γ, TNF-α, and IL-2 in response to in vitro stimulation with spike. (B) Percentages of persons with nonresponding CD4+ and CD8+ T cells or producing 1 to 3 cytokines pre- and postbooster. Differences between median frequencies of cytokine positive T cells at T6 and T12 were calculated by the Wilcoxon test. | PMC9726683 | gr1_lrg.jpg |
0.453534 | 51e51109bc7541f19568678e1a8f302f | T-cell mediated immune response in NH residents with a history of SARS-CoV-2 infection 6 months (prebooster, T6) and 12 months (postbooster, T12) after first immunization. (A) Frequencies of CD4 and CD8 T cells producing IFN-γ, TNF-α, and IL-2 in response to spike. (B) Percentages of previously infected NH residents with nonresponding CD4+ and CD8+ T cells or producing 1 to 3 cytokines pre- and post-booster. Differences between median frequencies of cytokine positive T cells at T6 and T12 were calculated by the Wilcoxon test. | PMC9726683 | gr2_lrg.jpg |
0.482819 | df2e6e2470a54119a7ee37fe86cce127 | T-cell mediated immune response in SARS-CoV-2 naïve NH residents 6 months (prebooster, T6) and 12 months (postbooster, T12) after first immunization. (A) Frequencies of CD4 and CD8 T cells producing IFN-γ, TNF-α, and IL-2 in response to spike. (B) Percentages of SARS-CoV-2 naive NH residents with nonresponding CD4+ and CD8+ T cells or producing 1 to 3 cytokines pre- and postbooster. Differences between median frequencies of cytokine positive T cells at T6 and T12 were calculated by the Wilcoxon test. | PMC9726683 | gr3_lrg.jpg |
0.462711 | 23b9dd85fb834cbd8f39019694cf464a | Loss of diversity characterizes inflammatory acne. Skin microbiota was evaluated on samples collected from the skin of ten healthy subjects (HS) and non-inflammatory (NI), and inflammatory lesions (LA) of ten acne patients. (a) Alpha diversity was calculated using the Shannon diversity index (HS vs. NI, P = 0.0209; HS vs. LA, P < 0.0001; LA vs. NI, P = 0.0118) and Pielou Evenness index (HS vs. NI, P = 0.0241; HS vs. LA, P < 0.0001; LA vs. NI, P = 0.0136). Statistical differences were determined using the Kruskal–Wallis test. (b) Bray Curtis beta diversity was calculated at the genus level and represented as principal coordinate analysis (PCoA). PERMANOVA test was used to assess significance. *, P < 0.05; **, P < 0.01; ***, P < 0.001, ****, P < 0.0001. | PMC9727105 | 41598_2022_25436_Fig1_HTML.jpg |
0.487558 | b08daedc02ea497c8843f12cc1ab3687 | Microbiota variation between healthy subjects and acne patients. Skin microbiota was evaluated on samples collected from the skin of ten healthy subjects (HS) and non-inflammatory (NI) and inflammatory lesions (AL) of 10 acne patients. Relative abundances at the phylum level (a) and top eight genera (b) were represented in a stacked bar plot. (c). Relative abundance was evaluated at the species level for Cutibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis relative abundances. Significance was assessed by using the Kruskal Wallis static test. *, P < 0.05; **, P < 0.01; ***, P < 0.001, ****, P < 0.0001. | PMC9727105 | 41598_2022_25436_Fig2_HTML.jpg |
0.426685 | df7a375540584808a305bfa8ec50cbea | Shared and unique genes in 20 C. acnes strains. Venn diagrams display the distribution of shared and unique genes between (a) C. acnes strains from healthy subjects (HS) and the lesional area of acne patients (LA) and (b) phylotypes IA1 and IB/II. Overlapping regions show the genes conserved within strains. The number between brackets represents the unique genes present in all the strains of a particular group. (c) The stacked bar chart of Cluster of Orthologous Genes (COGs) functional category proportions is based on the unique genes in all groups. The n above each group indicates the absolute count of COGs identified in each group. (d) Similarity matrix categories represent the presence (blue; +) or the absence (red, -) of C. acnes virulence genes and phylotype-specific genes. | PMC9727105 | 41598_2022_25436_Fig3_HTML.jpg |
0.448399 | 56f1c27683e34d4cbc015498b16d49ed | Biofilm formation of C. acnes strains. a Kinetic of bacterial adhesion was measured using the BioFilm Ring Test for C. acnes strains isolated from healthy subjects (HS) and the lesional skin of acne patients (LA) and (b) according to the phylotypes IA1, IB, II. C. acnes ATCC 1182 was used as a reference control strain. The mean and corresponding standard errors for three independent experiments of duplicate samples for each time point are shown. (c,d) The amount of biofilm biomass after 72 h was measured by the crystal violet assays (optical density (OD) at 595 nm). The mean and corresponding standard errors for three independent experiments of duplicate samples for each time point are shown. (e) Confocal microscopy image of biofilm formation of different C. acnes isolates and the C. acnes ATCC 1182 after 72 h of incubation in BHI at 37 °C. Significance was assessed by using the Kruskal Wallis static test. *, P < 0.05; **, P < 0.01; ***, P < 0.001, ****, P < 0.0001. | PMC9727105 | 41598_2022_25436_Fig4_HTML.jpg |
0.420667 | cbfb7b7f86df4302b3bf8d3879bfec3f | DNase I and Proteinase K reduce C. acnes adhesion. Comparison of extracellular DNA and proteins on early surface adhesion for the IA1 and IB/II phylotypes. Results are expressed as relative differences (Eq. 1) in the amounts of biofilm as measured by the BioFilm Ring Test after 6 h of incubation in the presence of DNase and Proteinase K compared with untreated control strains. Data represent means and the corresponding standard errors of two independent experiments analyzed in duplicate; *, P < 0.05; **, P < 0.01; ***, P < 0.001, ****, P < 0.0001 using the Mann–Whitney test. | PMC9727105 | 41598_2022_25436_Fig5_HTML.jpg |
0.358731 | f93de5291a144b6ebdbf940d71314314 | Antimicrobial tolerance in C. acnes isolates. (a) Antimicrobial susceptibility testing against ten C. acnes strains (phylotype IA1) isolated from the lesional skin of acne patients in planktonic and biofilm growth measured as minimum inhibitory concentration (MIC) and minimal biofilm eradication concentration (MBEC) for the indicated antibiotics. (b) Heat map showing the biofilm tolerance (BT), calculated as the ratio MBEC/MIC for ampicillin, benzylpenicillin, clindamycin, and doxycycline. Yellow indicates high BT values, and blue represents low BT for the indicated antibiotics. Statistical differences were determined using the Kruskal–Wallis test, followed by Dunn’s post hoc test for multiple comparisons. | PMC9727105 | 41598_2022_25436_Fig6_HTML.jpg |
0.524535 | 628a443e6a96424bbaeeddf8f9da1497 | The proposed strategy for screening and identifying the PK markers of SI. | PMC9727182 | FPHAR_fphar-2022-1062026_wc_sch1.jpg |
0.429512 | 2c3a0af2b9a94d179355e9c10ca9b4b6 | The heatmap for content determination results of multiple ingredients in SI. S1-1 to S1-5, S2-1 to S2-5, and S3-1 to S3-5 represent the five SI samples from the three batches of preparations (Nos. 19050511, 18113011, and 18101511, respectively); the number in each box represents the content of the relative ingredient in the corresponding sample with the unit of μg/ml. | PMC9727182 | fphar-13-1062026-g001.jpg |
0.433266 | 02dae11eb38b4257bb9f8557e9ef40ad | The mean plasma drug concentration–time curves and integrated plasma drug concentration-time curves of six ingredients after i.v., administration of SI with high (4 ml/kg, Mean ± SD, n = 3), medium (2 ml/kg, Mean ± SD, n = 3), and low (1 ml/kg, Mean ± SD, n = 4) dosages. | PMC9727182 | fphar-13-1062026-g002.jpg |
0.417712 | ab8ff54a8030498391d91f47f3e9c73c | DOSE analysis plots for the five ingredients, (A) HSYA, (B) SYR, (C) RU, (D) SCU and (E)
p-CA with favorable PK properties. The top 20 diseases relative to the corresponding ingredient and potential targets are shown in the graphs. | PMC9727182 | fphar-13-1062026-g003.jpg |
0.446622 | 0e7a2604d0c1427f9cbd6f17f05dc0a5 | Molecular docking combinations of (A) HSYA, (B) SYR and (C) RU with their receptor targets, LTA-4H, SDH, and CTSB. | PMC9727182 | fphar-13-1062026-g004.jpg |
0.454987 | 5d16c074084f49a79ede42e17a502e88 |
(A) Cell viability and (B) protection rate for the treatment of HSYA and SYR on cardiomyocytes injured by H2O2. *
p < 0.05 and **
p < 0.01 vs. model group (mean ± SD, n = 4); #
p < 0.05 and ##
p < 0.01 vs. NAC group (mean ± SD, n = 3). | PMC9727182 | fphar-13-1062026-g005.jpg |
0.390768 | 8327e69198fc4d32bab60dc9485e7357 |
(A) Represents the SDS-PAGE analysis for the total proteins of C, M, HSYA and SYR group. (B,C) show the PCA analysis score plot and the difference proteins numbers, respectively for M vs. C, HSYA vs. M and SYR vs. M groups. (D–F) show the difference expression proteins location in the comparisons for M vs. C, HSYA vs. M and SYR vs. M groups, respectively. (G–I) show the GO annotation results of the difference expression proteins for M vs. C, HSYA vs. M and SYR vs. M groups, respectively. (J–L) show the downregulation and upregulation pathways for M vs. C, HSYA vs. M and SYR vs. M groups, respectively. | PMC9727182 | fphar-13-1062026-g006.jpg |
0.452225 | 296876b39ab04f23bf2eb672c8ac5d74 |
(A) Venn diagram of PK marker identification for SI and (B) the integrated drug plasma concentration-time curves by the effect weighting integrated method with the plasma concentration of two ingredients HSYA and SYR after i.v., administration of SI with high (4 ml/kg, Mean ± SD, n = 3), medium (2 ml/kg, Mean ± SD, n = 3), and low (1 ml/kg, Mean ± SD, n = 4) dosages. | PMC9727182 | fphar-13-1062026-g007.jpg |
0.428009 | cf240dc5bbe3492b84354d612ecbff83 | Chemical structures of siderophores discussed
within the text,
with their respective iron binding units highlighted in color. Catechol
groups are highlighted in purple, and hydroxamate groups are highlighted
in pink. | PMC9727729 | ic2c02777_0001.jpg |
0.536908 | a0be5c98f42f418d80fd1520425e6897 | Schematic
representation of the switch in coordination modes as
exhibited by iron(III) catecholate siderophore complexes in response
to a change in pH through the protonation of the phenolic oxygen in
the meta position. | PMC9727729 | ic2c02777_0002.jpg |
0.47072 | cbd9c78e67a247cf86cb0b30bac6fcac | (A) A graphical
illustration of the “chelate
scale” demonstrating the relationship between the Fe3+/2+ reduction potential (Ep) and the stability
(log K) of iron(III) complexes with catechol ligands;
CDTA = cis-1,2-cyclohexylenedinitrilotetraacetate,
NTA = nitrilotriacetate, tiron = 4,5-dihydroxy-1,3-benzenedisulfonic
acid, cat = catechol, 4Ncat = 4-nitrocatechol, ent = enterobactin.
The purple solid line and the dotted lines represent the linear regression
and the 95% confidence interval, respectively. Adapted from ref (27). Copyright 1994 American
Chemical Society. (B) Model representations of the possible
stoichiometries for iron(III) complexes of tetradentate siderophores. | PMC9727729 | ic2c02777_0003.jpg |
0.429109 | aa5dd66a26b84a50a20c6184637a42a2 | Cyclic
voltammogram of an equimolar (M1:L1) iron(III)
azotochelin solution in a 5 mM BIS-TRIS buffer containing
100 mM NaCl at pH 7.0. Analyte concentrations of [Fe] = 0.45 mM and
[Az] = 0.45 mM; v = 10 mV s–1, Estep = 0.01 V. The arrow indicates the direction
of the current. | PMC9727729 | ic2c02777_0004.jpg |
0.490924 | 3b2915bd6cbd4421bda332ce1e48b842 | UV–vis absorption spectra of iron(III) azotochelin in a
5 mM BIS-TRIS buffer containing 100 mM NaCl at pH 7.0 as a function
of varying M:L ratios: 1:1 (1), 1:2 (2),
1:3 (3), and 2:3 (4). | PMC9727729 | ic2c02777_0005.jpg |
0.469514 | ddfdc6c1c27942598d53421d99ea4234 | (A) Cyclic voltammograms of iron(III) azotochelin
(M1:L1) in a 5 mM BIS-TRIS buffer, 100 mM NaCl
at pH 7.0. Analyte concentrations of [Fe] = 0.45 mM and [Az] = 0.45
mM; v = 10 mV s–1, Estep = 0.01 V. The arrow indicates the direction of the
current. (B) The pH dependence of the reduction potential
(Ep) for Fe(III) azotochelin, extracted
from CVs in (A). SD error bars are shown for pH 6.0, 6.5, and 7.0. | PMC9727729 | ic2c02777_0006.jpg |
0.442947 | 73a3081bc1c84262bcdf617b1e87373d | UV–vis absorption spectra of iron(III) azotochelin
in a
5 mM BIS-TRIS buffer containing 100 mM NaCl as a function of pH: 6.0
(1), 6.5 (2), and 7.0 (3).
Analyte concentrations of [Fe] = 0.45 mM and [Az] = 0.45 mM. | PMC9727729 | ic2c02777_0007.jpg |
0.465772 | 2262a4f8a78847b9900785758cd94eee | (A) Chemical structure of ferricrocin,
a tris(hydroxamate)
siderophore with its iron binding units highlighted in pink. (B) Cyclic voltammogram of a ferricrocin solution in a 5 mM
BIS-TRIS buffer containing 100 mM NaCl at pH 7.0. Analyte concentrations
of [Ferr] = 0.45 mM; v = 10 mV s–1, Estep = 0.01 V. The arrow indicates
the direction of the current. | PMC9727729 | ic2c02777_0008.jpg |
0.460967 | 1e67bed26aae4c29960f447c1613156a | ERAAP dsRed is expressed and properly localized in the ER.A. BJAB cells were transduced to express an ERAAP dsRed fusion. Cells were subcloned and selected for high expression of the construct as measured by flow cytometry. Histogram shows ERAAP dsRed levels in two selected clones, B2 (blue histogram) and D4 (orange histogram), in comparison to non-transduced BJAB cells (grey filled histogram). B. To test for proper ERAAP dsRed localization, Endo H assay was performed. WCL was collected from BJAB ERAAP dsRed clones B2 and D4 and ERAAP was immunoprecipitated using an anti-ERAAP antibody. Purified ERAAP was incubated with Endo H enzyme (Endo H +) or water (Endo H -) as a control. After treatment, ERAAP’s molecular weight was determined by western blot. Shown is a representative ERAAP blot. In non-treated samples, ERAAP dsRed appears as a ~150 kDa band (top set of arrows) while endogenous ERAP (WT ERAP; bottom set of arrows) can be observed as a ~100 kDa band. The appearance of a cleavage product of lower molecular weight indicates Endo H sensitivity. | PMC9727756 | nihpp-2022.11.29.518257v1-f0001.jpg |
0.421989 | b0e4bc4cbad04673891935f2f5a0b45c | ERp44 regulates ERAAP levels.A. To confirm the results of the CRISPR KO screen, BJAB ERAAP dsRed cells (clone B2) were transfected with two gRNA targeting ERp44 or one gRNA targeting ERAAP as a control. ERAAP levels in ERp44 KO cells were measured by western blot. Representative blot showing ERAAP and ERp44 protein levels in untransfected BJAB ERAAP dsRed (WT) and KO cells. GAPDH is shown as a loading control. B. Histogram showing ERAAP dsRed levels in BJAB ERAAP dsRed (blue histogram) and ERp44 KO cells (orange histogram). Parental BJAB cells are shown as a control (grey filled histogram) C. ERAAP secretion from ERp44 KO cells was measured by LAP assay. ERAAP was immunoprecipitated from the supernatants of BJAB ERAAP dsRed and BJAB ERAAP dsRed ERp44 KO cells. Beads containing ERAAP were incubated with LpNA substrate and LAP activity was measured 8 h after addition of the substrate by measuring optical density (OD) at 410 nm. Background activity coming from media was subtracted from both conditions. Shown is the fold change in LAP activity relative to BJAB ERAAP dsRed (WT) cells. Data represents mean± SD from three independent experiments. Unpaired two-tailed T-test was performed. ** p value < 0.01. | PMC9727756 | nihpp-2022.11.29.518257v1-f0002.jpg |
0.452298 | 98b7f69bce024915bbd19a92e6c8be57 | SARS-CoV-2 Envelope neutralizes the pH of the Golgi.A. HeLa cells were transfected with pHluorin-TGN38 alone (grey filled histogram) or co-transfected with pHluorin-TGN38 and SARS-CoV-2 E (blue histogram) or IAV M2 (green histogram). The fluorescence emission of pHluorin-TGN38 was measured by flow cytometry after excitation at 405 nm and 488 nm. Histogram shows the pHIuorin-TGN38 emission ratio (405 nm/488 nm) for each condition. B. Using a pH standard curve, the emission ratios values for each condition were used to calculate the pH of the Golgi. Shown are the calculated pH values for the Golgi space in HeLa cells transfected with pHIuorin-TGN38 alone or co-transfected with SARS-CoV-2 E and IAV M2. Data shown is from one representative experiment. SARS-CoV-2 abbreviated as SC2. | PMC9727756 | nihpp-2022.11.29.518257v1-f0003.jpg |
0.406812 | a16e4f5e9732430887d49e41cb525ac3 | SARS-CoV-2 Envelope leads to decreased ERAAP levels.A. HEK293T cells were co-transfected with ERAAP dsRed and SARS-CoV-2 E (blue histogram), or empty vector control (grey filled histogram) and ERAAP dsRed levels were measured by flow cytometry. Histogram shows ERAAP dsRed levels within transfected cells 24 h post-transfection. B. The geometric mean fluorescence intensity (gMFI) for dsRed was obtained from HEK293T co-transfected with ERAAP dsRed and SARS-CoV-2 E, or empty vector as in A. Graphs shows the percent dsRed gMFI 24 h and 48 h after transfection with SARS-CoV-2 E relative to empty vector across 3 independent experiments. Cells that were co-transfected with empty vector were assumed to represent 100% ERAAP dsRed levels and are shown as a control. Data represents mean± SD. Unpaired One-way ANOVA assuming a Gaussian distribution and Tukey’s multiple comparisons test was performed. *** p value < 0.001, ns=not significant. C. Representative blot showing ERAAP levels in HEK293T co-transfected with ERAAP 3XFlag and SARS-CoV-2 E, SARS-CoV-2 S, or empty vector control. WCL collected 36 h post transfection. GAPDH is shown as a loading control. D. From blots as that shown in C, the band intensity of ERAAP 3XFlag and GAPDH was determined using Image J. The relative ERAAP levels for each condition was obtained after normalizing to respective GAPDH levels. Graph shows the percent ERAAP 3XFlag levels in HEK293T transfected with SARS-CoV-2 E or an unrelated protein (ex. SARS-CoV-2 S). Cells that were co-transfected with ERAAP 3XF and empty vector were assumed to represented 100% ERAAP levels and are shown as a control. Data represents mean ± SD from 5 independent experiments for cells co-transfected with vector or SARS-CoV-2 E and from 3 experiments for unrelated protein. SARS-CoV-2 abbreviated as SC2. Unpaired One-way ANOVA assuming a Gaussian distribution with Tukey’s multiple comparisons test was performed. *** p value < 0.001, **** p value < 0.0001. | PMC9727756 | nihpp-2022.11.29.518257v1-f0004.jpg |
0.414556 | 566fdb211c0a487dbc8ce37d4da4e04a | ERAAP is secreted from cells expressing SARS-CoV-2 Envelope.LAP assay was performed on the supernatants of NIH 3T3 ERAAP dsRed transfected with empty vector or SARS-CoV-2 E. Background activity detected in the supernatant of untransfected NIH 3T3 ERAAP dsRed was subtracted from all conditions. LAP activity from the supernatant of NIH 3T3 ERAAP dsRed ERp44 KO cells was measured and assumed to represent 100% ERAAP release. Graph shows the percent of ERAAP released for each condition. Data represents mean ± SD from 3 independent experiments. Unpaired One-way ANOVA assuming a Gaussian distribution with Dunnett’s posttest was performed. ** p value < 0.01, **** p value < 0.0001. | PMC9727756 | nihpp-2022.11.29.518257v1-f0005.jpg |
0.426874 | 047d3e3667d24c84b837a74e2aef667b | A) Location map of early Acheulian sites in Africa. Inset shows eastern African sites mentioned in the text. Relief map from Natural Earth (public domain): http://www.naturalearthdata.com/ B) Relief map showing the terrain around the Melka Wakena site-complex (referred to as MW in the map). The boundaries of the Main Ethiopian Rift are marked by white dotted lines. MK = Melka Kunture site-complex. DEM from USGS National Map Viewer (public domain): http://viewer.nationalmap.gov/viewer/. The map was created by authors in QGIS. | PMC9728887 | pone.0277029.g001.jpg |
0.410771 | 4dd30a2682ca46168a957acc397e2b4e | A) Terrain map showing the general view of the Gadeb Plain B) Location of some of the archaeological localities along the meandering course of the upper reaches of Wabe River. Terrain map from USGS National Map Viewer (public domain): http://viewer.nationalmap.gov/viewer/. | PMC9728887 | pone.0277029.g002.jpg |
0.379817 | 750c2d081cb44fd8a00b61684a00278a | A) The stratigraphic sequence of MW2, showing the archaeological layers in relation to dated tephra. The photograph on the right shows the cliff face composed of the bottom part of the sequence (geological units I-VI) in which the archaeological layers are embedded. Note that the excavated area itself is not shown in this view. B) a partial view of the southern profile of the excavation (along squares G10 and H10), showing higher resolution details of the sedimentary make-up of geological units II and III and the stratigrpahic positions of MW2-L3 and MW2-L4 in relation to the sedimentary changes. C) Stratigraphic and lateral distributions of piece-plotted artifacts and bones in MW2-L3 and MW2-L4, projected onto a 2D-view. | PMC9728887 | pone.0277029.g003.jpg |
0.401884 | 899a97b11cf648f1a9d8a2951d51fe20 | A) MW2-L3 during excavation in 2016 (view to the south). Georeferenced distribution map of MW2-L3 (B) and MW2-L4 (C) lithic and fauna elements. | PMC9728887 | pone.0277029.g004.jpg |
0.438791 | 1395f752e9284b60a3fc1600f03ff958 | Box plot (with standard error) showing the average scar counts on the surface of cores and flakes (as per raw materials represented) from A) MW2-L3 and B) MW2-L1&L2. | PMC9728887 | pone.0277029.g005.jpg |
0.478914 | f3c05b6ea4ce4a7086833b7dba845d88 | Cores from the small to medium-sized flaking system from MW2-L4 (A), MW2-L3 (B–G), and MW2-L1&L2 (H); (A), (B), and (C) are Multifacial cores; (D) Bifacial abrupt partial (BAP) exploited core; (E) Core on flake; (F) Bifacial hierarchical centripetal (BHC) exploited core; (G) and (H) are Discoids. (A), (B), (E), (G), and (H) are made on glassy ignimbrite, (C) and (F) are made on ignimbrite, and (D) is made on basalt. The arrows indicate direction of flaking. | PMC9728887 | pone.0277029.g006.jpg |
0.472089 | 834f9a802d0545db8a9e6df9dac96626 | Large cores (A–D) and small debitage (E) cores from MW2-L3: A) Multifacial core (8 kg); B) Multifacial core (5.2 kg); C) Multifacial core (6 kg); D) Multifacial core (2.4 kg); E) Unifacial Centripetal (UC) exploited core. (A) and (C) are made on ignimbrite, (B) and (D) are made on glassy ignimbrite, and (E) is made on pumiceous ignimbrite. The arrows indicate direction of flaking. | PMC9728887 | pone.0277029.g007.jpg |
0.494237 | 1a13bec6357049ab9a68e93bb29871df | Crude LCTs (A–C), Pick (D), and Large scrapers/knives (E and F) from MW2-L3. (A) is made on special side-struck flake, (B), (C), (E) and (F) are on side-struck flake, and the blank of the pick (D) is indeterminate. All of the tools are made on glassy ignimbrite. Orange arrows indicate the direction of flaking of the blanks, while yellow arrows indicate the direction of removals during shaping phases. | PMC9728887 | pone.0277029.g008.jpg |
0.436874 | 40d15a9e8bc745ad908d37c66e031f85 | Trihedral picks (A and B), Cleaver (C), and Handaxes (D–F) from MW2-L1&L2. The picks and a cleaver are made on flakes (the arrows indicate the direction of flaking of flake blanks), whereas the blanks of the handaxes are indeterminate. All tools are made on glassy ignimbrite. Orange arrows indicate the direction of flaking of the blanks, while yellow arrows indicate the direction of removals during shaping phases. | PMC9728887 | pone.0277029.g009.jpg |
0.45617 | 7cc4ab16a94a4ac6804629886c15fe03 | Handaxes from MW2-L1&L2. (A), (B), and (C) are made on side-struck flake blanks (see the direction of the arrows), while the blanks of (D), (E), and (F) are indeterminate. All tools are made on glassy ignimbrite. Orange arrows indicate the direction of flaking of the blanks, while yellow arrows indicate the direction of removals during shaping phases. | PMC9728887 | pone.0277029.g010.jpg |
0.429203 | e8c80c2d8e9b457c823a940134ae1ae0 | Hammerstones from MW2-L3 (all except H) and MW2-L1&L2 (H): (A), (B), (C), (D), and (F) are ‘classic’ hammerstones from MW2-L3; (E), (G), and (H) are hammerstones with fractured angles. All except (C) are made on basalt. (C) is made on glassy ignimbrite. | PMC9728887 | pone.0277029.g011.jpg |
0.388834 | 2e3814d13a9746208edc9b88d1670d3c | The concept of matricellular proteins. The blue and gold arrows represent upregulation and downregulation, respectively. | PMC9730256 | fcell-10-1073320-g001.jpg |
0.433509 | 9f0baca3663d4ad4be516deb5bad8572 | A timeline of cutaneous wound healing (Reinke and Sorg, 2012) in connection with the timing of the expression of matricellular proteins (arrows) (modified, from Midwood et al., 2004). | PMC9730256 | fcell-10-1073320-g002.jpg |
0.520094 | a576f1cb97d44fd5a2e5ac8ad3b6017b | Timeline of phases and rationale of the UP150 concept and the present study's design (interventions, surveys, and analyses). | PMC9730336 | fpsyg-13-1006876-g0001.jpg |
0.427014 | e4d12dc5ea974ff28a09743849906dac | Example of architectural changes and setting for the UP150 office concept, and interaction with the UP150 App. | PMC9730336 | fpsyg-13-1006876-g0002.jpg |
0.372075 | c0fb0d3609754e1eba88e7812a112d34 | Participants' demographics concerning age and occupational role in the preliminary survey before the UP150 intervention study. | PMC9730336 | fpsyg-13-1006876-g0003.jpg |
0.345881 | 5cdc125be0054d52ae9873ea6e796fdd | Answers to the question concerning the beliefs about personal attention to nutrition and practicing physical activity. | PMC9730336 | fpsyg-13-1006876-g0004.jpg |
0.37671 | 1fca541b29bc4889a549179c8ae810a5 | Answers to the question concerning the beliefs about motivations toward practicing physical activity. | PMC9730336 | fpsyg-13-1006876-g0005.jpg |
0.386665 | 1b841d7d4c494b9399b50c69f156c246 | Answers to the question concerning what respondents consider a barrier to exercising. | PMC9730336 | fpsyg-13-1006876-g0006.jpg |
0.5301 | 452532a9cd684ee8a7ec3b82e3b80089 | Subjects emerging from the semi-structured interview that were administered after the UP150 intervention and analyzed by the grounded theory method. The figure reports: in blue, the core category; in dark gray, the most recurrent categories (frequency of pertinent labels >75%); in light gray, categories having a pertinent labels occurrence between 50 and 75%; in white, the most recurrent labels for each respective category (which have been mentioned by at least 50% of participants). | PMC9730336 | fpsyg-13-1006876-g0007.jpg |
0.422407 | 89e7433433a344ccb6e8d9e1ef29f125 | The rationale of the UP150 concept. | PMC9730336 | fpsyg-13-1006876-g0008.jpg |
0.466994 | 5d32849e219f4755b6dd039e5eda42a4 | Patient-reported outcomes over 3 years of follow-up. Values are the mean (95% CI). BRAF-MDQ: Bristol Rheumatoid Arthritis Fatigue-Multidimensional Questionnaire; EQ-5D-5L: European Quality of life 5-Dimensions 5-Levels; HADS: Hospital Anxiety and Depression Scale; HAQ-DI: Health Assessment Questionnaire–Disability Index; MDA, Minimal Disease Activity; VAS: Visual Analogue Scale. | PMC9730421 | rmdopen-2022-002706f01.jpg |
0.509044 | 7913ba61a7d84bd488aeac776fbc07a4 | Health-related quality of life for minimal disease activity (MDA) groups and the general Dutch population. (A) Mean health-related quality of life scores after 2 years. (B) Mean health-related quality of life scores after 3 years. Health-related quality of life was measured with the short form-36 domains. Health-related quality of life for MDA groups was compared with the general Dutch population norms (adapted from Aaronson et al [33]). | PMC9730421 | rmdopen-2022-002706f02.jpg |
0.494212 | c98c6d7b189147a18266f21d0102b1d6 | Biologic DMARDs usage for minimal disease activity groups. The percentage of patients per minimal disease activity (MDA) group who uses a biologic DMARD over time. | PMC9730421 | rmdopen-2022-002706f03.jpg |
0.467602 | 9a0a309343c94dce8e64373bfaad2cfe | Signaling pathways affected by luteolin | PMC9730645 | 12935_2022_2808_Fig1_HTML.jpg |
0.428752 | c653f0a2e1224afaac90484ded7555fa | Regulation of autophagy and apoptosis by luteolin | PMC9730645 | 12935_2022_2808_Fig2_HTML.jpg |
0.459354 | fcc75b4d5b4e419aa8bc871ce3de89d2 | The distribution of nucleosome-containing structures published per year since 1998 (A) subdivided by acquisition method, (B) structure resolution distribution (C) subdivided by type of structure: Free nucleosomes or nucleosomes in complex with non-histone proteins. (D) Visualization of nucleosome in complex with linker histone, linker DNA region is shown in light gray. (E) Variety of nucleosome components among the known structures. The PDB IDs for nucleosome component variants are presented in Supplementary Table S1. | PMC9730872 | fmolb-09-1070489-g001.jpg |
0.473077 | c8ed52d30504466ebfd8efe1f6d0cabd | Representation of NCP in protein complexes. The bar plot indicates the number of structures annotated by the molecular functions (see text). The structures of class representatives are depicted in circles with PDB IDs. The panel around PTM (post-translational modification) writers represents a number of structures associated with modification (methylation, ubiquitination, acetylation, PARylation and phosphorylation) of specific sites. The panel around chromatin remodelers represents the number of structures in the chromatin remodeler family, which are additionally subdivided into human and non-human complexes. The infographic does not include the following categories: Histone chaperone (three structures), Histone exchange (two structures), DNA integration (two structures). The PDB IDs for each protein category are presented in Supplementary Table S2. | PMC9730872 | fmolb-09-1070489-g002.jpg |
0.475816 | 4704d793fe8a4ba481aa260a2981dc15 | Treatment schedule and behavioral paradigms. (A) A summary of the treatment schedule. norBNI indicates norbinaltorphimine. (B) A scheme of the partition test. The dotted lines represent a transparent perforated Plexiglas wall. The red box shows the area that was designated as social interaction zone during video analysis. “A” stands for “actor” (subject animal), “P” stands for “partner”. (C) A summary of the open field test. The circles represent wire cups. The red and green rectangles represent, respectively, the social zone and the object zone during video analysis. | PMC9731130 | fnbeh-16-1057319-g001.jpg |
0.443476 | b1c931930931400baff4bce7672b9a5a | Locomotor activity during the habituation to the partition and open field tests. (A) Distance traveled during the habituation to the partition apparatus. (B) Activity during habituation to the open field. The group that received only saline is labeled “Sal sal”, ketamine followed by saline “ket sal”, and ketamine followed by norbinaltorphimine “ket norBNI”. Each dot represents an individual mouse. The bar and whiskers correspond to mean and SEM respectively. Group sizes are indicated above the graph. | PMC9731130 | fnbeh-16-1057319-g002.jpg |
0.406033 | 7c5b340e4edc4cc3842daaa9d0f0d3a4 | Social interaction in partition test. (A) time to first approach, (B) time spent in social zone, (C) mean distance to partner’s compartment. “Sal sal” corresponds to treatment with saline throughout the procedure, “ket sal” represents subchronic ketamine treatment and then saline injection before the test, and “ket norBNI” is ketamine treatment followed by single injection of norbinaltorphimine. The lines represent the mean and SEM. The numbers above the graphs indicate group sizes. | PMC9731130 | fnbeh-16-1057319-g003.jpg |
0.429781 | 062fcfef8e394d72bebe63a6c5ba5e6c | Social interaction in the open field. (A) Time spent in in the half of the cage with the partner mouse under the wire cup. (B) Time spent in the empty-cup zone. (C) Percent time spent in the social zone. (D) Time spent investigating the wire cup containing a partner mouse. (E) Time spent investigating empty cup. (F) Percent time spent investigating social cup. Groups are labeled as follows: “Sal sal” is the control group with only saline injections, “ket sal” corresponds to ketamine treatment and then saline, and “ket norBNI” is ketamine followed by norbinaltorphimine. Results are shown as mean and SEM. The numbers above the graphs indicate group sizes. | PMC9731130 | fnbeh-16-1057319-g004.jpg |
0.40697 | bac5a56c0776467eb8c836505dab6262 | Sampling location of P. nobilis individuals resistant or susceptible to H. pinnae parasite. (a) P. nobilis species is endemic to the Mediterranean Sea. (b) Individuals were sampled in three different locations in the Mediterranean Sea: Resistant from the sea were sampled in Peyrefite Bay (green), Susceptible from the Sea were sampled in Agde (Purple) whereas Susceptible from the Lagoon were sampled in Leucate (Red). RS, Resistant from Sea; SS, Susceptible from Sea; SL, Susceptible from Lagoon. | PMC9731998 | 41598_2022_25555_Fig1_HTML.jpg |
0.418864 | d1b960a853004b7798cfc3acebe7f209 | Resistant P. nobilis shows a specific differential expression genes profile. (a) Venn diagram showing the overlap of DEGs identified in RS vs SS, RS vs SL and SL vs SS. (b) Venn diagram showing the overlap of DEGs overexpressed in the two comparisons RS vs SS and RS vs SL. (c) Venn diagram showing the overlap of DEGs down-regulated in the two comparisons RS vs SS and RS vs SL. (d) 10 genes mostly significantly differentially regulated in both comparisons RS vs SL and RS vs SS and the protein associated. (e) Hierarchical clustering of samples (Ward’s method). The 1000 genes with highest variance were kept as dimensions. The percentage above each cluster divide represents the stability of the group as estimated by multiscale bootstrap resampling. Please note that the percentage that divides the clusters resistant with susceptible is equal to 100%. (f) Principal component analysis of samples. The 1000 genes with highest variance were kept as dimensions. RS, Resistant from sea; SS, Susceptible from sea; SL, Susceptible from lagoon. | PMC9731998 | 41598_2022_25555_Fig2_HTML.jpg |
0.426288 | 02e4c98da8ee482a938c50364a398431 | Gene ontology set analysis. (a) Venn diagram showing the overlap of GO terms that were enriched in DEGs identified in RS vs SS, RS vs SL and SL vs SS. (b) Common GO terms only between RS vs SS and RS vs SL. RS, Resistant from sea; SS, Susceptible from sea; SL, Susceptible from lagoon. | PMC9731998 | 41598_2022_25555_Fig3_HTML.jpg |
0.405773 | 0f1d81f1ed7e4cc1829c7ebfd87c623a | (A) Viscosity as a function of shear rate at 25 °C; (b) G’; (c) G”; and (d) tan δ as a function of angular frequency for Al–P solutions at various concentrations. | PMC9732126 | gr1.jpg |
0.43326 | 46c8adc1178f47f7be0eb2455de41bd1 | The particle size of Al–P hydrogels generated via (a) the conventional and (b) 3D food printing methods. *NO PRODUCT means it was not possible to form droplets from 2.2 wt% TGC using the nozzle size of 0.108 mm inner diameter. The nozzle size of 0.337 mm was used for comparison with the literature. Different letters above data points indicate that they are significantly different (p < 0.05). | PMC9732126 | gr2.jpg |
0.41185 | a5066bd3452d473badeea493cd9ed525 | Pictures of Al–P hydrogel particles generated using (a) the conventional and (b) 3D food printing methods. *No product means it was not possible to form droplets from 2.2 wt% TGC using the nozzle size of 0.108 mm inner diameter via the conventional method. | PMC9732126 | gr3.jpg |
0.525282 | 9706bf637bad4439a1346859672f393d | SEM images of freeze-dried Al–P particles. All the particles were formed using a 3D food printing system with a nozzle size of 0.159 mm. | PMC9732126 | gr4.jpg |
0.454515 | e3e7d92aad0c42f4a71afcd9f7609429 | XRD patterns of the (a) pectin, (b) alginate, and 3D-printed Al–P particles produced using TGC of (c) 1.8, (d) 2.0, and (e) 2.2 wt%. (CrI: Crystallinity index). | PMC9732126 | gr5.jpg |
0.554973 | 25ae365721654a2ca96988450d3a7f61 | ATR-FTIR spectra of the (a) pectin, (b) alginate, and 3D-printed Al–P particles produced using TGC of (c) 1.8, (d) 2.0, and (e) 2.2 wt%. | PMC9732126 | gr6.jpg |
0.408821 | 8ecbd1aedd6a4a64aff755852dd845c5 | The surgical procedure of triplanar osteotomy and transverse distraction. A A triplanar osteotomy (6.5 cm in height with a width of 1.5 cm) was created on the medial cortex of the proximal tibia along the 3 sides (proximal, distal, and lateral) of the rectangle; the medial margin of the tibia was used as the medial side of the rectangle. B–D 2 curved skin incisions were made. The external fixator was assembled after triplanar osteotomy and insertion of half pins | PMC9733084 | 13018_2022_3410_Fig1_HTML.jpg |
0.469342 | 8de65704c0b94f84868e0f3014a34040 | A 68-year-old man suffered from recalcitrant diabetic foot ulcer for 2 years. A Ischemic and necrotic toes and soft tissues at distal foot preoperatively. B Preoperative CTA image showed small vessels of the affected calf and foot were damaged. C, D The necrotic tissues were removed after debridement. E, F The triplanar osteotomy and external fixator sites were confirmed on radiographs postoperatively. G, H After medial distraction, the bone fragment is transported medially. I the image showed the affected foot during distraction. J The bone fragment was completely united 4 weeks after removal of the external fixator. K The ulcer was completely healed at 10 weeks postoperatively. L Postoperative CTA image showed more small vessels were present in the affected limb | PMC9733084 | 13018_2022_3410_Fig2_HTML.jpg |
0.488405 | d9b836fce52644e6975a687e086e6789 | Mass spectrometry analysis of urinary eicosanoids. Urinary levels of the prostacyclin urinary metabolite 2,3-dinor-6-keto-PGF1α (left panel), the thromboxane A2 metabolite thromboxane B2 (middle panel), and the cysteinyl-leukotriene E4 (right panel). Urine was collected from patients at baseline, 24-48 h (Early) and after treatment (End) following intravenous infusion (2 mL/kg) of either placebo (NaCl; black symbols, n = 12) or n-3 PUFA emulsion containing 10 g of n-3 polyunsaturated fatty acid emulsion per 100 mL (blue symbols, n = 10) for 5 days. Results (mean ± SEM) are expressed as pg/mg creatinine. Statistical analyses were performed with 2-way ANOVA for repeated measures and post hoc testing. *p < 0.05 compared to baseline and #p < 0.05 between placebo and n-3 PUFA treatment. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.) | PMC9733960 | gr1_lrg.jpg |
0.463372 | a9049e057e0b4494b9a0fc00c43ad7a0 | Mass spectrometry analysis of urinary isoprostanes (IsoP) derived from polyunsaturated fatty acids (PUFA). The left panel shows the n-6 PUFA-derived isoprostane 15(RS)-15-F2t-IsoP and the middle panel shows the n-3 PUFA-derived isoprostane 5(R)-5-F3t-IsoP. Results (mean ± SEM) are expressed as pg/mg creatinine. The right panel shows the ratio (mean ± SEM) between total urinary IsoP derived from n-3 and n-6 PUFA. Urine was collected from patients at baseline, 24-48 h (Early) and after treatment (End) following intravenous infusion (2 mL/kg) of either placebo (NaCl; black symbols, n = 10) or n-3 PUFA emulsion containing 10 g of n-3 PUFA per 100 mL 100 mL (blue symbols, n = 10) for 5 days. Statistical analyses were performed with 2-way ANOVA for repeated measures and post hoc testing. *p < 0.05 compared to baseline and #p < 0.05 between placebo and n-3 PUFA treatment. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.) | PMC9733960 | gr2_lrg.jpg |
0.42354 | 37f4828c693140c4acedd68e889723b1 | Erythrocyte oxidative stress. The upper panel illustrates the oxidation reaction of the CMH-hydrochloride probe by ROS into EPR visible species (left) and shows representative spectra obtained by EPR spectroscopy from the measurement of ROS produced by erythrocytes derived from patients randomized to either placebo (black) or i. v. n-3 PUFA treatment (blue). The lower panel shows the absorbance (mean ± SEM) for measurement of ROS production following CMH-hydrochloride incubation of erythrocytes derived from patients at baseline, at 24-48 h (Early), and after treatment (End) with i. v. infusion (2 mL/kg) of either placebo (black symbols, NaCl; n = 5) or n-3 PUFA emulsion containing 10 g of fish oil per 100 mL (blue symbols; n = 5). Statistical analyses were performed with 2-way ANOVA for repeated measures and post hoc testing. **p < 0.01 compared to baseline and #p < 0.05 between placebo and n-3 PUFA treatment. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.) | PMC9733960 | gr3_lrg.jpg |
0.415099 | a36e04b41a464bad8c69a9f877cbec81 | Model. | PMC9734089 | gr1_lrg.jpg |
0.529696 | a56cbe2af10a4848a29129379349022d | The timing of UK COVID-19 restrictions and Google mobility data for transit stations (the timing of the implementation of policies are shown in red and the relaxation of policies are shown in green. The Google mobility index (shown in grey) was computed by taking the daily average for the UK) | PMC9735226 | 10940_2022_9564_Fig1_HTML.jpg |
0.404802 | fa7015efb17345c393f7a3ea28b60cec | Time series for online shopping fraud (a), hacking (b) and doorstep fraud (c), Google mobility and online sales | PMC9735226 | 10940_2022_9564_Fig2_HTML.jpg |
0.485746 | 054c4d52a38e421bb9bf726ba8edcde7 | The lemon peel is a waste used to prepare the lemon extract. | PMC9735538 | materials-15-08328-g001.jpg |
0.502277 | 80155e7a662543d893eecc6f9440a9b4 | The diffractograms from samples M1, M2, M3, and M4 match the diffraction patterns of magnetite (Fe3O4). | PMC9735538 | materials-15-08328-g002.jpg |
0.441252 | dd13ff2d74b542d2a4b6a89d25cc6f7c | Diffractogram of magnetite nanoparticles obtained by the chemical co-precipitation and green chemistry method at 95 °C. | PMC9735538 | materials-15-08328-g003.jpg |
0.518897 | 4da0f91e5a754369adae95f029a7ab18 | The SEM images of synthesized magnetite nanoparticles at magnifications of 10 µm and 100 µm for the samples M1 (a,b); M2 (c,d); M3 (e,f), and M4 (g,h). | PMC9735538 | materials-15-08328-g004.jpg |
0.487007 | ada8947f6cc94ff79ac5561fb0713d56 | EDS spectra of the magnetite, where the presence of the oxygen and iron elements that constitute the sample were determined in percentages. | PMC9735538 | materials-15-08328-g005.jpg |
0.45782 | 8a079b54d1604cecb23c75941d45bb43 | High-Resolution Transmission Electron Microscopy (HRTEM) images of the three representative samples M1 (a,b) M2 (c,d), and M3 (e,f), operating under magnifications of 20 nm and 10 nm; synthesized at a temperature of 25 °C, 55 °C, and 85 °C, respectively, by the green chemistry method. | PMC9735538 | materials-15-08328-g006.jpg |
0.469814 | 7ee822c2b9c64277a8487cf11560f0dc | Scheme of nanoaggregates of Fe3O4 nanoparticles. | PMC9735538 | materials-15-08328-g007.jpg |
0.452007 | a0ddcc7683ff46ec8ab352715ee9fe46 | Images of HRTEM of obtained magnetite nanoparticles at a magnification of (a) 50 nm and (b) 60 nm of the sample. A uniform size distribution is observed in both images. | PMC9735538 | materials-15-08328-g008.jpg |
0.437852 | 58c865cc18ff40eaa0e55a03cd41a996 | The particle size distribution plot at the nanoscale shows a size distribution of M1 sample. The histogram shows the frequency distribution of the nanoparticles with a normal distribution curve. | PMC9735538 | materials-15-08328-g009.jpg |
0.419067 | 4f6b18e041754934a70bdfe1e377c744 | Images of TEM of obtained magnetite-graphene oxide composite, at 50 nm and 100 nm for the M1 sample. | PMC9735538 | materials-15-08328-g010.jpg |
0.497939 | 537b2f3835b94b3fbf6aee623ce155d8 | The magnetic curve of synthesized nanoparticles at room temperature. | PMC9735538 | materials-15-08328-g011.jpg |
0.450209 | ac0cc4a1145541c881126f2e4d850353 | Image of magnetite nanoparticles: (a) suspension of Fe3O4, (b) by the effect of the magnet. | PMC9735538 | materials-15-08328-g012.jpg |
0.421036 | f07d78e66db94c2c81c1875d32a61692 | Incorporation of the nanoparticles into the Acqua 100 matrix. Obtaining the coating. From left to right the 0.5 wt. % and 1 wt. % coatings (a,b) before mixing and (c,d) after mixing. | PMC9735538 | materials-15-08328-g013.jpg |
0.457717 | 97c35bf6085c4b2496147c1fce6d45fe | (a) Coated samples for tribology assays and (b) coated samples for electrochemical tests. | PMC9735538 | materials-15-08328-g014a.jpg |
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