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Surface profile analysis in (a) finished prototype with second phase milling, (b) higher magnification of milled surface, and (c) topographical profile measurement along the traverse direction to the milling cutter.
PMC9740583
materials-15-08631-g023.jpg
0.436323
009fc668cd6446b78544e25037d6e2a2
Illustration of prototype (a) finished after second phase of milling, (b) higher magnification of machined surface, and (c) topographical analysis in the direction of tool feed movement.
PMC9740583
materials-15-08631-g024.jpg
0.468345
c7cd19ab8e7f4579962b535147d91d16
Optical microscopy of prototype cross-section wall with 11 layers (a) at 50× magnification, and (b) site with porosity and dendritic structure visible at 500× magnification. Red arrow inset in (a) shows the direction of cutting of the WAAM cross-section of AlSi5 blade piece.
PMC9740583
materials-15-08631-g025.jpg
0.468662
bdf43e5d2202472686f73ea93b28d2c5
Tensile test-fractured specimens: (a) 5 with longitudinal angle of 0° with respect to base orientation of the layers, and (b) 7 with transverse orientation of 90° of welding layers with respect to base.
PMC9740583
materials-15-08631-g026.jpg
0.421671
b24d71f4a9844fa39d7fa56437e07440
The stress–strain graph illustrates the elongation of the test pieces (a) in the transverse direction to the welding direction, and (b) in longitudinal to welding directions.
PMC9740583
materials-15-08631-g027.jpg
0.409152
164956b7311a47aba252d8f2c7ed6720
The time distribution histogram for the weldment-processing operations.
PMC9740583
materials-15-08631-g028.jpg
0.386138
c899af84cf5d4282b4fde0566cbadd8d
The time distribution histogram for the milling operations.
PMC9740583
materials-15-08631-g029.jpg
0.397842
2bd201a6c1fb493295160aaec0e7f726
The mechanism for preparation of PRO@DMON–GA–Fe(III) nanoparticle (A). The triggered release mechanism of prochloraz from PRO@DMON–GA–Fe(III) nanoparticles (B).
PMC9741037
nanomaterials-12-04249-g001.jpg
0.427671
a6c55df071284609bb92ae34da4bab41
EDX spectra of DMON nanoparticles, PRO@DMON nanoparticles and PRO@DMON–GA–Fe(III) nanoparticles (A). TEM mapping of PRO@DMON–GA–Fe(III) nanoparticles (B–H).
PMC9741037
nanomaterials-12-04249-g002.jpg
0.400204
b814df32b7f245a4a71b849276b0402c
TEM images of DMON nanoparticles (A,C) and PRO@DMON–GA–Fe(III) nanoparticles (B,D).
PMC9741037
nanomaterials-12-04249-g003.jpg
0.435438
0a16e0d53ed7450eb985c13c28b7a45a
XPS spectra of DMON nanoparticles (A), PRO@DMON nanoparticles (B), and PRO@DMON–GA–Fe(III) nanoparticles (C). FTIR spectra of prochloraz, DMON nanoparticles, PRO@DMON nanoparticles, and PRO@DMON–GA–Fe(III) nanoparticles (D). Nitrogen adsorption–desorption isotherms (E), and BJH pore size (F) of DMON nanoparticles, PRO@DMON nanoparticles, and PRO@DMON–GA–Fe(III) nanoparticles.
PMC9741037
nanomaterials-12-04249-g004.jpg
0.445385
30c6c16b0a57485ebf1c14368d30a4e8
Degradation behaviors of DMON nanoparticles in 10 mM glutathione solution at 0, 2, 5, and 10 days.
PMC9741037
nanomaterials-12-04249-g005.jpg
0.467776
33c216a5a75f4cdd8b9f95eb29d5c2d4
Effect of glutathione on the release performance of prochloraz from PRO@DMON–GA–Fe(III) nanoparticles.
PMC9741037
nanomaterials-12-04249-g006.jpg
0.436591
2af380d51a6f4267869ce110c7cf23c7
Stabilities of prochloraz technical, prochloraz emulsifiable concentrate, and PRO@DMON–GA–Fe(III) nanoparticles under UV radiation (A). Pseudo-first-order models of prochloraz photodegradation for prochloraz technical, prochloraz emulsifiable concentrate, and PRO@DMON–GA–Fe(III) nanoparticles (B).
PMC9741037
nanomaterials-12-04249-g007.jpg
0.471834
def906112a0a42af848d2822cfcb58b9
Contact angles and adhesion works of PRO@DMON nanoparticles and PRO@DMON–GA–Fe(III) nanoparticles on rice blades.
PMC9741037
nanomaterials-12-04249-g008.jpg
0.426464
289eae93cf4b466fba2e6949f0f45fdb
Fungicidal activities of prochloraz emulsifiable concentrate and PRO@DMON–GA–Fe(III) nanoparticles evaluated with Magnaporthe oryzae.
PMC9741037
nanomaterials-12-04249-g009.jpg
0.419288
1ab3f2be95ac41e39f3cc60d271c2a4d
Cubic phase stabilization without vacancy formation.a, b X-ray diffraction patterns of garnet with respect to number of dopants in Zr site. c, d X-ray and neutron diffraction patterns and Rietveld refinement of Li7La3Zr0.4Hf0.4Sn0.4Sc0.4Ta0.4O12.
PMC9741625
41467_2022_35287_Fig1_HTML.jpg
0.409092
751fa6ed170d4cbb84cf057c5f0f76df
Local structure of Zr site and formation enthalpy with respect to number of dopant species.a Local crystal structure of the Zr site with adjacent Li site for the tetragonal phase and b the cubic-phase of garnet. Li1 and Li2 sites for the cubic-phase indicate the 24d tetrahedral and 96h octahedral site, respectively. c Calculated structural parameters of average bond distortion index and bond angle variance between metal and oxygen in the Zr octahedral site as the tetragonal and cubic phase with Li7La3M2O12 composition. d Difference in formation enthalpy energy between the cubic and tetragonal phase with respect to number of dopant species.
PMC9741625
41467_2022_35287_Fig2_HTML.jpg
0.413432
8428707526b54f2aa3491a86a46de3cb
Operando phase evolution during calcination for various numbers of dopants in Zr site.a–c Contour plots of X-ray diffraction patterns during heating and d–f cooling process in 14–20°. White arrow indicates the temperature of cubic phase formation or phase transition temperature from cubic to tetragonal phase.
PMC9741625
41467_2022_35287_Fig3_HTML.jpg
0.45088
a2d6459550634829b02522b30a6215f8
Electrochemical impedance variations in entropy-driven cubic-phase garnet in Li||Li symmetric cell for different lithium contents.a, b Nyquist plots for the coin-type Li||Li symmetric cells with Li7La3Zr0.4Hf0.4Sn0.4Sc0.4Ta0.4O12 and Li6.6La3Zr0.4Hf0.4Sn0.4Sc0.2Ta0.6O12 garnet at 60 °C without additional external pressure. Inset figures describe equivalent circuit model and scheme of interfacial layer structure with Li metal. c Variation in interfacial resistance for Li||Li symmetric cells as a function of time at 60 °C (time interval between measurements: 32 min). d Li stripping and plating profile of Li7La3Zr0.4Hf0.4Sn0.4Sc0.4Ta0.4O12 and e Li6.6La3Zr0.4Hf0.4Sn0.4Sc0.2Ta0.6O12 at 60 °C with a current density (J) of 0.2 mA cm–2.
PMC9741625
41467_2022_35287_Fig4_HTML.jpg
0.425324
b6fa4c4521c24b36aacfa7636cf1e0c1
Battery performance of the quasi-all-solid-state Li||NCM111 cells comprising Li7La3Zr0.4Hf0.4Sn0.4Sc0.4Ta0.4O12 as solid electrolyte.a Electrochemical profile of solid-state batteries at 60 °C with a current density (J) of 0.8 mA/cm2 from first to fifth cycles. Inset is the Nyquist plot of the cell at 25 °C before cycling. b Charge/discharge voltage profile with current density (J) increasing from 0.6 to 2.2 mA/cm2 (∆J = 0.2 mA/cm2) at 60 °C. c Long-term cycling stability performance of the quasi-all-solid-state Li||NCM111 cell at 60 °C and 0.8 mA/cm2.
PMC9741625
41467_2022_35287_Fig5_HTML.jpg
0.480666
44eafd455dd54825b84bfbaa5b5e72ec
Overview of proposed sentiment classification workflow
PMC9742011
13278_2022_998_Fig1_HTML.jpg
0.451238
52320ad70efd4a6d8e0100583621b590
Sentiment proportion of dataset
PMC9742011
13278_2022_998_Fig2_HTML.jpg
0.468219
2c7e1c6cbaad4f869c9d39dd73b28b75
Classification accuracy on binomial dataset
PMC9742011
13278_2022_998_Fig3_HTML.jpg
0.44883
fc11bd751ecd4778b492c706b3d9f1f3
Classification accuracy on polynomial dataset
PMC9742011
13278_2022_998_Fig4_HTML.jpg
0.434192
6c69f93cf56d45c08280f6fc4ee79120
Study design and demonstration of high IGHV1-69 diversity among the donors(A) Schematic representation of the sampling of 14 SARS-CoV-2 RT-PCR+ study participants followed by IGH genotyping and memory B cell sorting 7 months after the infection.(B) Spike-specific IgG in serum samples from the 14 study participants.(C) Serum ID50 neutralization values against the ancestral virus in the serum samples.(D) Amino acid sequence alignment of functional human IGHV1-69 alleles.(E) A summary plot showing which IGHV1-69 alleles were present in each study participant.(F) Schematic illustration of IGHV1-69 alleles present on each chromosome of eight study participants. Neutralization measurements were repeated twice.See also Figure S1.
PMC9742198
gr1_lrg.jpg
0.423525
7e86839d213849a68061a63176bfa571
Spike-specific memory B cell sorting yields several IGHV1-69∗20-using neutralizing mAbs(A) Dendrogram showing IGHV, IGKV, and IGLV alleles present in SP14.(B) Panels showing the gating strategy used to sort single S-specific CD20+CD27+IgG+ B cells.(C) Comparison of IGHV allele usage in the total and spike-specific IgG repertoires of SP14.(D) Number of HC sequences from sorted B cells and clonal lineages derived from the total HC sequences.(E) Pie chart showing the proportion of neutralizing (blue) and non-neutralizing (orange) antibodies among the 29 isolated mAbs.(F) Genetic and functional properties of the 15 neutralizing mAbs isolated from SP14. Neutralization measurements were repeated twice.See also Figure S2.
PMC9742198
gr2_lrg.jpg
0.452219
314de188b5204f128db782d2b1e223e1
IGHV1-69 allele usage influences CAB-I47 neutralizing activity(A) Amino acid sequence alignment of the IGHV1-69∗20 germline allele with the V gene region of CAB-I47.(B) The design of CAB-I47 germline-reverted HC sequences and swaps to the IGHV1-69 germline alleles ∗20, ∗01, ∗02, ∗04, ∗06, or ∗10, which were paired with the mature CAB-I47 LC for functional testing (left). Neutralizing activity of the variant mAbs against the ancestral SARS-CoV-2 strain is shown as curves (middle) and IC50 values (μg/mL) (right).(C) Design of the mature CAB-I47 with the HCDR2 F55L substitution, paired with the CAB-I47 mature LC (top panel). Neutralization activity of CAB-I47 and CAB-I47 F55L against the ancestral SARS-CoV-2 strain (bottom left) and IC50 values (μg/mL) (bottom right). Neutralization measurements were repeated twice.See also Figure S3.
PMC9742198
gr3_lrg.jpg
0.418845
574245b6837e413b84fdf07f31a69e2c
IGHV1-69∗20-using neutralizing mAbs isolated in an independent donor(A) Dendrogram showing IGHV alleles present in SP13.(B) Serum ID50 neutralization values against ancestral SARS-CoV-2 at pre- and post-vaccination time points.(C) Panels showing the gating strategy used to isolate single spike-specific CD20+CD27+ IgG B cells.(D) Comparison of IGHV allele usage in the total and spike-specific IgG repertoire of SP13.(E) Pie chart showing the number of HCs of the total IGHV1-69-using HCs using a given IGHV1-69 allele from the sorted B cells.(F) Genetic and functional properties of the selected neutralizing mAbs.(G) Neutralization of the ancestral SARS-CoV-2 strain by the mature CAB-M77 and CAB-N86 mAbs with and without the F55L mutation.(H) Neutralizing activity by CAB-M77 and CAB-N86 with their HC V gene regions reverted to the IGHV1-69 germline alleles ∗20, ∗01, ∗02, ∗04, ∗06, or ∗10, tested against the ancestral SARS-CoV-2 strain. Neutralization measurements were repeated twice.See also Figure S4.
PMC9742198
gr4_lrg.jpg
0.422082
09d4caac90b8442a99c36ecfdcf66f94
Cryo-EM analysis of the spike-CAB-I47 Fab complex reveals its binding mode(A) Cryo-EM reconstruction of the spike-CAB-I47 Fab complex in 1-up conformation, three CAB-I47 Fabs occupy the RBDs (left). The cryo-EM map (gray transparent) overlayed with atomic model, trimeric spike with three the CAB-I47 Fab variable domains (middle). Atomic model of RBD- the CAB-I47 Fab (variable domains) with the HCDR1, HCDR2, and HCDR3 color-coded (right).(B) Molecular details of the CAB-I47 Fab and RBD interaction with residues important for the interaction labeled.(C) The IGHV1-69∗20 F55 residue (shown in red) located in a hydrophobic pocket of the RBD. The RBD is shown in surface representation and colored according to relative hydrophobicity with various RBD residues in the binding area are labeled.See also Figure S5.
PMC9742198
gr5_lrg.jpg
0.431246
5f723a7722d74e90986e5273ddbe3c82
Substitution of the germline-encoded R50 residue abolishes the activity of CAB-I47(A) Cartoon and stick representation of the IGHV1-69∗20 R50 residue interactions with G482 and E484 on the RBD, color coding as in Figure 5 (left). Neutralization of the ancestral SARS-CoV-2 strain by the mature CAB-I47 and versions containing the F55L mutation, the R50G mutation or both, and ELISA binding by the same antibodies against RBD (right).(B) Summary of variant amino acid positions in different IGHV1-69 alleles with the presence of R50 and F55 highlighted in red. Gray background indicates alleles that were evaluated in this study. Neutralization measurements were repeated twice.See also Figure S6.
PMC9742198
gr6_lrg.jpg
0.449626
b05a72f788fe4de68424c5086b48f81f
Scree plots of C19-OCS
PMC9744046
41811_2022_155_Fig1_HTML.jpg
0.458945
181c9707b8f04af2ac070ddcecceb3c2
Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA-ScR) flow diagram for study inclusion
PMC9745731
10935_2022_718_Fig1_HTML.jpg
0.437621
5e8929000ea14c478aa8c181ac093f73
Choropleth Map showing the geographical distribution of the indigenous population within the articles included in the review
PMC9745731
10935_2022_718_Fig2_HTML.jpg
0.38702
7d43b7923f5d4544935a2c8524a13019
Number of included studies by years of publication (n = 29)
PMC9745731
10935_2022_718_Fig3_HTML.jpg
0.450026
9b128799c03d4c1bba88a306a28f1a5b
Expanded Conceptual framework of climate change impacts on indigenous health
PMC9745731
10935_2022_718_Fig4_HTML.jpg
0.398343
94a3c4f9413643afa966386ad521b06b
Overview of field experimental sampling, sample processing, and analysis. (A) Mean daily temperature based on station BZBM3 in Woods Hole, MA. Dates range from October 2020 to May 2021. The shaded region represents the time in which corals were in quiescence. Lines refer to sampling periods around dormancy: yellow indicates before; the blue line refers to when corals went into quiescence; gray lines refer to quiescence; purple lines refer to after quiescence. Above the plot, the line and labels refer to when samples were taken, the designation of sample points, and naming of the phases of dormancy. (B) Schematic of the sampling protocol for corals (n = 10 per time point) and water (n = 4 per time point) and analyses.
PMC9746315
aem.01391-22-f001.jpg
0.396337
890d1721af9b428abfe2b4054db16921
Coral microbiome alpha diversity decreases during quiescence. Plots show the mean ± standard error (SE) of alpha diversity measures. Colors indicate before (yellow), during (gray), and after (purple) quiescence. The active microbiome and present microbiome are separated by facets and by shape (circles and triangle, respectively). Smaller, transparent points represent raw values. (A) Hill D0 (rarefied richness); (B) D1 exponentiated Shannon diversity (not rarefied); (C) D2 or inverse Simpson diversity. D0 and D1 decreased during quiescence and then increased after quiescence in active microbes; however, in the present microbes, the diversity only changed (increased) after dormancy. Conversely, D2 remained low before and during quiescence and increased after quiescence for both DNA and cDNA.
PMC9746315
aem.01391-22-f002.jpg
0.472496
381a930118724bf7b9ee27b6c2522d95
Coral microbiome beta diversity alters during quiescence. (A to D) The plots show mean ± SE beta dispersion of the (A) active and (B) present microbiomes for the coral (n = 9 to 10) and mean ± SE of the coral (n = 9 to 10) and water (n = 4) microbial communities in NMDS space in the (C) active and (D) present microbiomes. Colors represent timing, and shape indicates coral (squares) or water (diamonds) in the NMDS plot and active (circles) and present (triangles) in the dispersion plots. The numbers inside of the shapes (C and D) indicate the sampling time (see Table 1). Beta dispersion (A and B) was generally high but was significantly lower at time point 3, the sampling point before the onset of quiescence. Microbial community composition differed significantly (P < 0.05) based on timing, sampling time, and active/present microbiomes based on PERMANOVAs on the corals and the water (panels C and D).
PMC9746315
aem.01391-22-f003.jpg
0.485371
81a3597f6f0a4a99abbebb6221b6ce24
Relative abundance of selected active taxa (indicated by order and genus) that were significantly different according to the corncob analysis on the active microbiome-based ASVs. Points represent the relative abundance of ASVs in each coral (9 to 10 samples). Lines are a loess representation of the shape of the relationship based on the geom_smooth function in ggplot (in R). (A to G) Plots include taxa that were enriched before quiescence and at the first one or two time points during quiescence, (A) Pseudoalteromonas (Alteromonadales), (B) Arcobacter (Campylobacterales), (C) Lentisphaera (Lentisphaerales), (D) Endozoicomonas (Oceanospirillales), (E) MD3-55 (Rickettsiales), and (F) Midichloriaceae, and those that were enriched during quiescence, (G) UBA10353 marine group. (H to O) Lastly, those that were enriched as corals were midway through quiescence and continued to increase after quiescence, (H) Paraglaciecola (Alteromonadales), (I) Aureispira (Chitinophagales), (J) Pseudofulvibacter (Flavobacteriales), and (K) Cm1-21 (Nitrosococcales), or those that increase as corals come out of quiescence, (L) MSB-1D1 (Nitrosococcales), (M) Pseudahrensia (Rhizobiales), (N) Filomicrobium (Rhizobiales), and (O) Magnetospira (Rhodospirillales). Additional data are presented in Fig. S2.
PMC9746315
aem.01391-22-f004.jpg
0.43187
2209f24fb7d64f0fac0b6e7a8992a951
Conceptual diagram of the diversity and community shifts that occurred in the Astrangia poculata microbiome before, during, and after quiescence. Illustrations by Alicia Schickle.
PMC9746315
aem.01391-22-f005.jpg
0.437063
385a7c2c6b024ab385150bc410f1db39
A. Computed tomography (CT) image of Phantom HD1; B. CT image of Phantom HD2; C. Region of interest (ROI) positions for Hounsfield unit (HU) analysis
PMC9746644
rpor-27-5-821f1.jpg
0.415922
8ef3fd61cb7f4a88a05a5940d1083041
Image difference color wash. MARCT — computed tomography with metal artifact reduction; WOMARCT — computed tomography without metal artifact reduction
PMC9746644
rpor-27-5-821f2.jpg
0.48162
2daa07e0e6fe416a87617abe1e129cbd
Hounsfield unit (HU) profile of different metal inserts (WOMARCT)
PMC9746644
rpor-27-5-821f3.jpg
0.472722
30acc5c662a04e9886532ff03ff94ea1
Calculated dose profiles at stainless steel level
PMC9746644
rpor-27-5-821f4.jpg
0.521058
328dbca35a06482baa8c0d330c0748d2
Gamma evaluation of computed tomography with metal artifact reduction (MARCT) and computed tomography without metal artifact reduction (WOMARCT) calculated dose distributions
PMC9746644
rpor-27-5-821f5.jpg
0.421169
afb8e4b674bc4425b1710d4de95272e7
Numbers of surgical pathology reports issued by pathologists at the Hospital de Messejana before and during the COVID-19 pandemic, and their relationship with the total numbers of COVID-19 cases and deaths in the state of Ceará, Brazil. In A, surgical pathology reports issued between 2015 and 2021. Each dot represents the number of reports issued each month. There was a significant reduction in the numbers of reports issued in 2020 and 2021 in comparison with those issued in the 2015-2019 period (p < 0.05). There was no significant difference between the numbers of reports issued in 2020 and 2021. In B and C, linear relationship of the numbers of surgical pathology reports issued by pathologists at the Hospital de Messejana with the numbers of COVID-19 cases (B) and deaths (C) occurring between January of 2020 and December of 2021. Each dot represents one month in the analyzed period.
PMC9747184
1806-3756-jbpneu-48-06-e20220248-gf1.jpg
0.420008
807c7508c1584a56b65d90ed9cdf8fc8
IL-27 production is enhanced in response to BCG stimulation in neonatal BMDCs. Day 8 (D8) BMDCs were treated with BCG at an MOI of 0.5-2.5 for indicated time periods. a BMDCs were harvested for RNA isolation and measurement of IL-27p28 (left) or EBI3 (right) gene expression after 6 (top) or 24 h (bottom). Values were normalized to β-actin and expressed as log2 change in expression relative to the unstimulated controls using the formula 2−ΔΔCt. Mean results ± standard error from 9 (BCG) or 6 (LPS) combined experiments averaged from 2-3 technical replicates from batched BMDCs per experiment are shown. Following a normality test, statistical significance in the 95% confidence interval was determined using a One-Way ANOVA and Tukey's multiple comparison test to compare treatment groups to the non-treated samples, ***p=0.0004, **p=0.0046. b IL-27 concentrations in culture supernatants were measured by ELISA after 24 h. Absolute values were normalized to the amount of IL-27 per 105 cells to control for differences in cell density across experiments. Mean results ± SEM for a combined 5 (BCG) or 2 (LPS) experiments averaged from 2-3 technical replicates from batched BMDCs per experiment is shown. Statistical significance in the 95% confidence interval was determined using a non-parametric Kruskal-Wallis and Dunn's multiple comparison test, *p=0.048.
PMC9747568
gr1.jpg
0.481037
138cfd2839d7400780d996ed818ae161
IL-27 signaling opposes BCG clearance in neonatal BMDCs. Day 8 (D8) WT or KO BMDCs were treated with BCG at an MOI of 0.8-2 with or without IFN-γ. At 4 or 72 h, cells were fixed and stained with Auramine O. a A representative measurement of BCG internalization at 4 h is shown as relative fluorescent units (RFU) ± standard error. b Normalized BCG recovery from BMDCs at 72 h for a combined 3 experiments averaged from 3 technical replicates from batched BMDCs per experiment ± standard error is shown. RFU values at 72 h were normalized to those at 4 h within an experimental group. The normalized value of each group was then expressed relative to the BCG-treated WT BMDC group to compare killing ability across experiments. Following normality testing, statistical significance in the 95% confidence interval was determined using a one-sample t test;*p=0.04; **p=0.005.
PMC9747568
gr2.jpg
0.408643
f2fc6d1d0fec4ff08e46dc410c4c2fcf
IL-27 opposes production of IL-12 in response to BCG stimulation in neonatal BMDCs. WT and KO BMDCs from day 8 mice were treated with BCG at an MOI of 0.8-2 or LPS for 6 or 24h. a Cells were harvested after 6h for RNA isolation and measurement of IL-12p35 (left) or IL-12p40 (right) gene expression. Values were normalized to β-actin and expressed as log2 change in expression relative to the unstimulated controls using the formula 2−ΔΔCt. Mean results ± standard error from 3 combined experiments averaged from 2-3 technical replicates from batched BMDCs per experiment are shown. b IL-12p70 concentrations in culture supernatants at 24 (left) or 48 h (bottom) were measured by ELISA. Mean results ± standard error for an experiment representative of 3 experiments performed separately are shown. Statistical significance in the 95% confidence interval was determined using a two-way ANOVA followed by Sidak's multiple comparison test; *p=0.03, **p= 0.006.
PMC9747568
gr3.jpg
0.435908
a8d902a4c8e14381bd7a9de1570c1837
IL-27 signaling limits T cell stimulation by neonatal BMDCs. BMDCs from neonatal WT or KO mice were seeded at 2×104(a) or 104(b) cells per well and treated with BCG at an MOI of 1.6-3. A group of BMDCs treated with TNF-α was included to mature BMDCs without BCG as a control for antigen specificity. At 24 h post-stimulation, CD4+ T cells from adult-vaccinated WT mice were cultured with BMDCs at a constant density of 105 cells per well. Through 72 h of co-culture, samples of supernatant were saved every 24 h to measure production of IFN-γ by ELISA. Mean results ± SEM at 48 (left) or 72 h (right) for an experiment representative of 3 experiments performed separately is shown. Statistical significance in the 95% confidence interval was determined using a two-way ANOVA followed by Sidak's multiple comparison test; ****p < 0.0001.
PMC9747568
gr4.jpg
0.430006
095bc3e8041d4bcdb44e52af6fab965f
BCG is poorly cleared from neonatal WT mice and elevates IL-27 levels. Neonatal WT or KO pups were vaccined at 7 or 8 days of life with a target of 103 BCG per animal. Male and female mice were both used and distributed approximately equally between treatment groups. Mice were rested for five weeks after vaccination. a Three WT and two KO vaccinations were performed to obtain the requisite number of animals. At the study endpoint, mice were humanely euthanized and lungs, livers, and spleens were harvested, homogenized, and serially diluted to enumerate BCG. Following normality tests, statistical significance in the 95% confidence interval was determined using non-parametric Mann-Whitney tests comparing WT to KO mice for each sample; *p=0.018 (lung), **p=0.001 (liver), **p=0.003 (spleen). b Four independent neonatal vaccinations were peformed to obtain the requisite number of animals. Serum was obtained from weekly blood collections by submandibular bleeding and were measured by electrochemiluminescent immunoassay. Statistical significance in the change of IL-27 within treatment groups over time in the 95% confidence interval was assessed by mixed-effects analysis and Sidak's multiple comparison test. Following normality tests, statistical significance in the 95% confidence interval between control and BCG vaccinated within a time point was determined by pairwise comparison with unpaired t tests; *p=0.041 (4 week) and *p=0.034 (5 week).
PMC9747568
gr5.jpg
0.433415
3e59433d26964d6d82ea3a0ae3651268
Response, survival and cost by treatment group. (A) Response; (B) Progression-free survival; (C) Overall survival; (D) Chemotherapy completion rate; (E) Average length of hospital stay; (F) Average total hospital cost per course per patient; (G) Average antibiotic costs per course per patient.
PMC9747713
41598_2022_24922_Fig1_HTML.jpg
0.422438
42593634e89441a988e20d0517f18afa
Kaplan–Meier survival curves and landmark analysis. (A) Progression-free survival by pathological subtype (GCB vs. non-GCB); (B) Progression-free survival by response (CR vs. not CR) at the end of induction chemotherapy; (C) Landmark analysis of progression-free survival by response (CR vs. not CR) at the end of induction chemotherapy; (D) Overall survival by subtype (ECOG > 3 vs. ECOG ≤ 3); (F) Overall survival by response (CR vs. not CR) at the end of induction chemotherapy; (E) Landmark analysis of overall survival by response (CR vs. not CR) at the end of induction chemotherapy.
PMC9747713
41598_2022_24922_Fig2_HTML.jpg
0.396818
70e920cf9d15409b81ff2d2bc879d392
Elements of Strong Structuration TheoryFrom Stones (2005).
PMC9748305
gr1.jpg
0.40995
b3175c6fcb654c4dbce161973437a3e3
Restricted cubic spline of TMAO levels in relation to hazard ratio for the risk of clinical endpoint (n = 163). Dark red line with 95% confidence interval shaded in light red. HR hazard ratio; CI confidence interval; TMAO trimethylamine-N-oxide
PMC9749156
12931_2022_2282_Fig1_HTML.jpg
0.420055
4b62dea1849c490b8753733e6f11f9de
Kaplan–Meier analysis for the incidence of composite outcome events. PH patients (n = 163, P < 0.001 (A), IPAH/HPAH patients (n = 36, P = 0.010 (B), CHD-PAH (n = 76, P < 0.001, (C), and CTEPH (n = 51, P = 0.170 (D) were analysed. Composite outcome events include death, rehospitalisation due to heart failure, and at least 15% decreased 6MWD from the baseline. P-value calculated by the log-rank test. TMAO trimethylamine-N-oxide; PH pulmonary hypertension; IPAH/HPAH idiopathic/heritable pulmonary arterial hypertension; CHD-PAH pulmonary arterial hypertension associated with congenital heart disease; CTEPH chronic thromboembolic pulmonary hypertension; 6MWD 6-min walk distance
PMC9749156
12931_2022_2282_Fig2_HTML.jpg
0.442522
fad108d4048c46f28334ca14f10914d7
Emerging issue identification (ERI) workflow
PMC9749435
EFS2-20-e200913-g001.jpg
0.480226
cd23a0793fa14add8e34268b33ed27d8
Topic detection and visualisation with InfraNodus software after the selection of the topic ‘food safety’
PMC9749435
EFS2-20-e200913-g002.jpg
0.427178
197340310a094185a82fa86a3c7f9194
Topic detection and visualisation with InfraNodus software
PMC9749435
EFS2-20-e200913-g003.jpg
0.525631
62b23cc3d1b64815b029e1cd6d2cf85f
Network design of the overall autophagy biosynthetic network. Solid arrows represent transition between the different biochemical components. Solid lines represent association among biochemical components. Branch points (BP) represent biochemical transitions or associations that are related to more than 2 biochemical components.
PMC9749836
gr1_lrg.jpg
0.459054
e3f081164f604984b723b47bf33f840b
Centrality analyses of the overall autophagy biosynthetic network. Significant biochemical components based on (A) betweenness, (B) stress, (C) closeness, (D) eccentricity, (E) radiality, and (F) edge betweenness centralities are indicated. Significant nodes are colored green. Significant edges are marked by solid red arrow lines. Threshold for each centrality measurement is shown on the upper left. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
PMC9749836
gr2_lrg.jpg
0.409633
cc05545eaff84bf4844f5ec0ef943856
Unified network highlighting common nodes and edges established from centrality measurements. Significant nodes are colored green. Significant edges are marked by solid red arrow lines. Branch points (BP) represent biochemical transitions or associations that are related to more than 2 biochemical components. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
PMC9749836
gr3_lrg.jpg
0.467797
3520c1bc899f41be95401efc452dcd1c
Quantification of LAM in EBC from TB patients and control individuals listed in Table 1.Quantity of LAM in EBC samples from all the subjects involved (a), adults (b), and children (c, e) was determined by an immunoassay using the CS-35 anti-LAM antibody. A receiver-operating characteristic (ROC) analysis of the LAM quantitation data is shown in d. AUC area under the curve, T threshold. In a, b, and c, the difference between TB patient groups and controls (healthy, pneumo) was statistically significant (Mann–Whitney U-test, two-tailed). Error bars represent SEM. Source data are provided as a Source Data file.
PMC9751131
41467_2022_35453_Fig1_HTML.jpg
0.417719
d7d313edd06e49bda8280aa4ff112a7a
Characterization of LAM in EBC by NMR.Expanded region (δ 1H: 4.80-5.50, δ 13C 98-114) of the 2D 1H-13C HSQC spectrum in D2O at 298 K of Ad S+ pool (a) and Ch S+/C+ pool (b) LAM-enriched fractions, and Mtb_broth LAM (c). Cartoons show the structure of arabinan side chain termini deducted from NMR data. The branched hexa-arabinofuranoside (Ara6) motif is the main epitope of the CS-35 anti-LAM antibody. Structural motifs that differ between LAM in EBC and LAM purified from M. tuberculosis H37Rv grown in broth are highlighted in blue.
PMC9751131
41467_2022_35453_Fig2_HTML.jpg
0.452498
86b8d27a9766456b899e2f74e7ca9563
M. tuberculosis lipids and corresponding MS signatures detected in EBC from TB patients.a Negative MALDI-TOF mass spectrum of PI and PIMs. A structure of tetra-acylated PIM2 (Ac2PIM2) that contains 2 palmitic (C16), 1 stearic (C18) and 1 tuberculostearic (C19) acids is drawn. * indicate intense ions that do not correspond to PIM molecular species. b Negative MALDI-TOF mass spectrum of Ac4SGL. A structure that contains 2 hydroxyphthioceranyl (HPA) and 1 phthioceranyl (PA) (SL-II according to the nomenclature of Goren) is drawn. c Positive ESI-QTOF mass spectrum of PDIM. MCA, mycocerosic acid. d, e Negative ESI-QTOF mass spectrum of α- (d) and methoxy-(e) mycolic acids. The main forms are illustrated. f Positive ESI-QTOF mass spectrum of TbAd. 1-TbAd isomer is shown. Data are representative of at least 2 independent experiments on each EBC pooled sample. The precise stereochemistry of PIMs, SGLs, PDIM and Mycolic acids can be found in Minnikin & Brennan, 202028. A detailed peak assignment is shown in Supplementary Tables 4–7.
PMC9751131
41467_2022_35453_Fig3_HTML.jpg
0.537582
74d02bf1ef9d441093c06d083807c8b7
Abundance of M. tuberculosis lipids in EBC from TB patients and control individuals listed in Table 1.Abundance of MA (a–c), TbAd (d–f), and PDIM (g–i) per EBC from adults and children was determined by SFC-HRMS relatively to 1,2-ditridecanoyl-sn-glycero-3-phosphocholine (133 ng/mL of EBC) used as an internal standard (IS). Values are given as the ratio between areas of the extracted ion chromatograms (AEIC) of the ionized lipid molecular species and AEIC of the IS. In g, h, and i, values are multiplied by 10. In a, b, d, e, g, h, unless otherwise stated (ns, not significant), the difference between TB patient groups and controls (healthy, pneumo) was statistically significant (Mann–Whitney U-test, two-tailed). Error bars represent SEM. Source data are provided as a Source Data file.
PMC9751131
41467_2022_35453_Fig4_HTML.jpg
0.486476
3d762b0d587e433a8318974e2e49dbc4
Abundance of M. tuberculosis proteins in EBC from TB patients and control individuals listed in Table 1.a Number of Mtb proteins detected by proteomic analysis in the corresponding groups. b–i Abundance of selected Mtb proteins by proteomic analysis. j–l Abundance of GroEL2 protein by an immunoassay. In b–i, values are given as the Label-Free Quantification (LFQ) intensity (int.). The noise background intensity was ~3.3 log. In j–l, values are given in arbitrary units corresponding to intensity (int.) on the Dot Blot (DB) and normalized to levels of GroEL2 in the Mtb cell lysate. In j and k, unless otherwise stated (ns, not significant), the difference between TB patient groups and controls (healthy, pneumo) was statistically significant (Mann–Whitney U-test, two-tailed). Error bars represent SEM. Source data are provided as a Source Data file.
PMC9751131
41467_2022_35453_Fig5_HTML.jpg
0.437497
543e4982a759403795a18b453134c9a9
(A) Centralized manufacturing facility: Point of care and point of manufacturing is geographically seperated. (B) De-centralized manufacturing facility: Point of care and manufacturing is the same.
PMC9751310
fonc-12-1062296-g001.jpg
0.427561
373c46f98b6c45adbcbe881afcaea76c
Possible mechanism of action of steroids in the management of COVID-19.
PMC9751434
fphar-13-1063246-g001.jpg
0.397151
ab4d671400914fc6bdd820b4b52e69ad
Possible mechanism of action of NSAIDs in the management of COVID-19.
PMC9751434
fphar-13-1063246-g002.jpg
0.466949
6b3f262e8e244861a01c679bc2beb6b4
Structure of steroids used in the management of COVID-19. (A) Methylprednisolone, (B) Hydrocortisone, (C) Dexamethasone.
PMC9751434
fphar-13-1063246-g003.jpg
0.502962
158c67ed8fc54041b7877e111511257a
SARS-CoV-2 entry and effect of ibuprofen. ACE2 = Angiotensin converting enzyme 2, TMPRSS2 = Transmembrane serine protease 2, S1/S2 = SARS-COV-2 spike protein subunits.
PMC9751434
fphar-13-1063246-g004.jpg
0.500597
af1d81c4de194ac2bdadf1b1f86cb57c
Structure of NSAIDS used in the management of COVID-19. (A) Aspirin, (B) Meloxicam, (C) Celecoxib, (D) Naproxen, (E) Ibuprofen, (F) Indomethacin (G) Ketotifen.
PMC9751434
fphar-13-1063246-g005.jpg
0.481051
a1ca37887a0546a187099582dc96de68
Distribution of low- and lower-middle-income countries across the world.
PMC9751812
fonc-12-976168-g001.jpg
0.449324
a5ea81cb293343a6b6d9de8fd50dc2db
Flow chart of screening and study selection processes.
PMC9751812
fonc-12-976168-g002.jpg
0.423624
1173c27d36874d25afe1de4c4819a08f
Characteristics of studies on ML-based models for cancer outcomes in LLMICs. (A) Bar plot showing the frequency of studies by publication year (B) Geographic distribution of studies on ML-models for cancer in LLMICs by country (C) Bar plot showing the study design and number of centers involved during model construction (D) Plot showing the frequency of cancers for which models were developed in the LLMIC population.
PMC9751812
fonc-12-976168-g003.jpg
0.438075
a3c74008d50f443baedcd49de0c324be
Distribution of studies by the PROBAST domains.
PMC9751812
fonc-12-976168-g004.jpg
0.464494
3ef05f0d3c944dd68427d18b7d1d0874
Plot showing the different techniques used for ML-based model construction for cancer patients in LLMICs (A) Model types (B) Novelty of backend algorithm used for model construction (C) Patient cohort size for model construction (D) Functions of the ML-based models.
PMC9751812
fonc-12-976168-g005.jpg
0.408722
9dee67dd87e545b0b4fe020e64e8fec0
Bar and violin plots evaluating the methods used for model development and summary model performances (A) Plot of features used for model construction by publication year (B) Plot of ML technique by the rating of model development processes (C) Plot showing summary accuracy estimates for the three different ML techniques (D) Plot showing summary accuracy for ML-based models for diagnosis according to the cancer types (E) Plot showing summary accuracy for ML-based models for cancer screening according to the cancer types (F) Plot showing summary accuracy for ML-based models for cancer prognosis according to the cancer types.
PMC9751812
fonc-12-976168-g006.jpg
0.430758
b27b4e789d56408da26c68266a287f0e
Mean physical self-concept score and 95%-confidence interval for separate subscales for physical self-concept in children 5 through 12 years in patients (ARM/HD) and controls (range 1 to 4 points). All values lie in the upper section of the scale. There were no significant differences between patients or controls. (PSK-K = physical self-concept-Kinder, ARM = anorectal malformation, HD = Hirschsprung’s disease)
PMC9753325
12887_2022_3782_Fig1_HTML.jpg
0.472659
1c09699cfcd24c97a8150aa141aea627
Mean physical self-concept total score and 95%-confidence interval in children 5 through 12 years in patients (ARM/HD) and controls (range 21 to 84 points). There were no significant differences between the mean (dotted line) and 95%-confidence interval (blue box) of the control group compared to patients, including influencing factors, such as gender or being able to swim. The PSK-K score of patients with HD was significantly higher compared to all other subgroups. (PSK-K = physical self-concept-Kinder, HD = Hirschsprung’s disease, ARM = anorectal malformation, VACTERL = VACTERL association)
PMC9753325
12887_2022_3782_Fig2_HTML.jpg
0.410157
b3d820241fec413d932c3ded60de01b7
a-c Mean PSK score and 95%-confidence interval for separate subscales for physical self-concept in adolescents 13 through 25 years in patients (ARM/HD) and controls (range 1 to 4 points). a. In the analysis of both genders, the mean scores for sports competence, endurance, speed and flexibility were significantly lower compared to controls. b. In females, there was a significant and major deficit in the subscales for sports competence, endurance, speed, strength and flexibility. c. In males, only the score for flexibility was significantly reduced compared to controls. (* significant difference, PSK = physical self-concept, ARM = anorectal malformation, HD = Hirschsprung’s disease)
PMC9753325
12887_2022_3782_Fig3_HTML.jpg
0.437475
bc612b4c9d964f3b92b99763a1ab3d76
Mean physical self-concept total score and 95%-confidence interval in children 13 through 25 years in patients (ARM/HD) and controls (range 46 to 184 points). Even though a reduced physical self-concept score in patients compared to controls is evident, there were no significant differences between the mean (dotted line) and 95%-confidence interval (blue box) of the control group compared to patients, including influencing factors, such as gender or type of malformation. Patients, who are not able to swim have a significantly reduced physical self-concept score compared to controls. (PSK = physical self-concept, HD = Hirschsprung’s disease, ARM = anorectal malformation, VACTERL = VACTERL association)
PMC9753325
12887_2022_3782_Fig4_HTML.jpg
0.43844
fca9c31b5e35409684aadef345498968
Enrolment and outcome in the French NeuroCOVID multicenter registry.
PMC9753577
gr1_lrg.jpg
0.459696
bd4054efcc0a4f5fafeb392d6e7c6f70
Flowchart showing Rwanda Artificial Intelligence for Diabetic Retinopathy Screening trial enrollment. AI = artificial intelligence; DR = diabetic retinopathy.
PMC9754978
gr1.jpg
0.460313
17e0ce7d529e4fa48bca94aa237aef09
Flow chart of the literature search and study selection.
PMC9755205
fphar-13-1004821-g001.jpg
0.411422
89cf9537375d48ccae69d4917b8ff824
Quality assessment for risk of bias for the included randomized controlled trials.
PMC9755205
fphar-13-1004821-g002.jpg
0.448636
fd6ee19648f347a18dd57e53a779a3c8
Forest plots of meta-analyses between ICIs combination with chemotherapy or not vs chemotherapy in PD-L1 positive TNBC (A) for progression-free survival and (B) for overall survival.
PMC9755205
fphar-13-1004821-g003.jpg
0.415481
31d2f369a18b45e39f9e653414b013a6
Subgroup analysis of the effect of ICIs combined with chemotherapy or not on PFSin PD-L1 positive TNBC patients.
PMC9755205
fphar-13-1004821-g004.jpg
0.388965
ee96e2372d664c9e8e53213eff3010cb
Subgroup analysis of the effect of ICIs combined with chemotherapy or not on OS in PD-L1 positive TNBC patients.
PMC9755205
fphar-13-1004821-g005.jpg
0.415414
5c1606c0345a4cde8e8ba8d328cc6192
Subgroup analysis of the effect of ICIs combined with paclitaxel or not on OS in PD-L1 positive TNBC patients.
PMC9755205
fphar-13-1004821-g006.jpg
0.437517
38ca89882bfd4ae0a6c14836155c35a2
Sensitivity analysis (A) for progression-free survival and (B) for overall survival.
PMC9755205
fphar-13-1004821-g007.jpg
0.432117
05400dc92a9343559a65ca8676d544f2
Egger’s test of publication bias (A) for progression-free survival and (B) for overall survival.
PMC9755205
fphar-13-1004821-g008.jpg
0.39863
61d535f211f143a68859ebe7bc86a8c9
Cascaded metalenses in the near infrared. a Schematic of the aberration-free metalens doublet focusing off-axis light. b Illustration of the dielectric metasurface used to implement the metalens. The metasurface array is composed of amorphous silicon posts with variant diameters and SU-8 polymer on top in hexagonal arrangement. The MTF of c polynomials doublet and d hyperbolic singlet metalens. The focal length and aperture diameter of both lens is set as the same. Image taken by e the doublet and f the singlet. a–f Reprinted with permission from Ref. [81]. Copyright 2016, Arbabi et al.
PMC9756243
12200_2022_17_Fig10_HTML.jpg
0.458912
c2bf74e0f6524519bc0c3d0b5e41042b
Metalens doublet in the visible: schematic illustration, SEM image and phase profile of the metasurface doublet. a Metalens doublet is comprised of two metasurfaces integrated on both sides of a SiO2 substrate. b–e Geometrical parameters of the TiO2 nanofins; c–e side and top views of the hexagonal unit cell with constant periodic length S, nanofin height H, nanofin length L, width W, and variant rotation angle \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\alpha$$\end{document}α. f Top-side view SEM micrograph of the focusing metalens. g Side view SEM micrograph at the edge of the sample. h Phase plot of aperture metalens. i Comparison of phase plots of hyperbolic metalens and that of focusing metalens designed based on Eq. (10). j–l Ray diagrams to depict the principle of aberration correction. j Ray diagram of hyperbolic metalens which shows large aberration at oblique illuminance. k Ray diagram of metalens with phase profile designed according to light blue curve in Fig. 9g, which shows positive and negative spherical aberration. l Ray diagrams of the metalens doublet showing diffraction-limited focusing at all angles. a–l Reprinted with permission from Ref. [82]. Copyright 2017, American Chemical Society
PMC9756243
12200_2022_17_Fig11_HTML.jpg
0.442299
fb2e87feac5042e395d93e72a2eaebbf
Wide-angle metalens with aperture stop. a Schematic of the hexagon unit cell composed of SiO2 nanopost placed on GaN substrate with fixed height 600 nm. b Simulated images of USAF-1951 test chart with traditional lens and c wide-angle metalens. d Traditional lens layout. e Traditional lens Strehl ratio. f Traditional lens MTF. g Metalens layout. h Metalens Strehl ratio. i Metalens MTF. The NA of the optical system in both the designs is set to 0.18, and the cutoff frequency is approximately 600 in cycle per mm. a–i Reprinted with permission from Ref. [86]. Copyright 2020, Fan et al.
PMC9756243
12200_2022_17_Fig12_HTML.jpg
0.392306
7d9c5a0f90c540058afa0628990ba2fa
Proof-of-concept quadratic phase metalens. a Ray diagram of wide-angle flat lens illuminated by oblique rays. Red, yellow and blue rays are corresponding to different incident angles. The lens transforms the difference in incident angles into traverse shifts of focuses on the focal plane. b Ray diagram of an ordinary lens and a quadratic flat lens at normal illumination. Spherical aberration is introduced in the quadratic lens. c Top: SEM of the fabricated metalens with elliptical aperture arrays on a gold film. Bottom left: simulated results of light intensity distributions on xz (y = 0) and xy (z = 7.5 μm) plane at 632.8 nm with \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$0^\circ ,-32^\circ ,-80^\circ ,\text{and } 45^\circ$$\end{document}0∘,-32∘,-80∘,and45∘ incident angles. Bottom right: experimental measurement of light intensity distribution on xz plane at \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\theta =0^\circ ,-32^\circ$$\end{document}θ=0∘,-32∘ and \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\theta =0^\circ ,-80^\circ$$\end{document}θ=0∘,-80∘. The FWHM is about 427 nm. d Top: schematic of measurement set up to demonstrate the multiwavelength behavior. Bottom: intensity distribution in a common focal plane shows clear spots for three wavelengths. a–d Reprinted with permission from Ref. [93]. Copyright 2017, The Optical Society
PMC9756243
12200_2022_17_Fig13_HTML.jpg
0.423253
e3051535f0ef451b9bcb7207f88ae462
Quadratic phase metalens with arbitrarily wide FOV. a Schematic of the c-Si nanopost unit cell with fixed period a = 190 nm and height h = 230 nm. b Transmission and phase map. D refers to the diameters of c-Si nanoposts and the cycle marks represent the eight phase levels used to discretize the phase profile. c SEM micrograph of the c-Si nanopost array (top view). d Measured displacement of the focal spot as a function of incident angels. e Measured and simulated FWHM versus incident angles curves of hyperbolic (referred to as D.L. in the graph) and quadratic (referred to as WFOV) lens. a–e Reprinted with permission from Ref. [92]. Copyright 2020, American Chemical Society
PMC9756243
12200_2022_17_Fig14_HTML.jpg
0.447763
26a6e032def84b4e881fe06cb7aed311
Inverse designed single-piece multilayer metalens that simultaneously corrects chromatic and angular aberrations. Top-left is the schematic of the metalens consisting of 20 layers of 3D-printable polymers with NA = 0.24. Top-right inset shows the distribution of Strehl ratio (SR) of intermediate frequencies and angles within the designated bandwidth and FOV. Most SRs remain higher than 0.7 and the mean value is larger than 0.75. The bottom shows the cross-section light field distributions and AEs of the designed wavelengths and angles (N = 10 × 10 = 100). The average of AEs is as high as 55%. Reprinted with the permission from Ref. [61]. Copyright 2021, AIP Publishing
PMC9756243
12200_2022_17_Fig15_HTML.jpg