prognosis/cardio-docs-qa · Datasets at Hugging Face

What is the name of the procedure performed during pregnancy?

Percutaneous balloon valvuloplasty

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the procedure performed during pregnancy?. ### Response: Percutaneous balloon valvuloplasty.

When was the last time a systematic review of cardiovascular surgery and pregnancy was conducted?

1984–1996

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last time a systematic review of cardiovascular surgery and pregnancy was conducted?. ### Response: 1984–1996.

What was the time period from 1984-1996?

1984–1996

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the time period from 1984-1996?. ### Response: 1984–1996.

What was the time period 1984-1996?

1984–1996

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the time period 1984-1996?. ### Response: 1984–1996.

What is the name of the journal published in 1998?

Am J Obstet Gynecol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal published in 1998?. ### Response: Am J Obstet Gynecol.

How are left-sided heart valves evaluated in pregnant women?

Echocardiographic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are left-sided heart valves evaluated in pregnant women?. ### Response: Echocardiographic.

What is the name of the drug used to monitor anti-Xa in pregnant patients with mechanical prosthetic valves receiving low-molecular-weight heparin?

peak or trough levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used to monitor anti-Xa in pregnant patients with mechanical prosthetic valves receiving low-molecular-weight heparin?. ### Response: peak or trough levels.

What are the results of the monitoring of anti-xa?

peak or trough levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of the monitoring of anti-xa?. ### Response: peak or trough levels.

Who is the author of the study?

Vinayakumar D, Vinod GV, Madhavan S

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of the study?. ### Response: Vinayakumar D, Vinod GV, Madhavan S.

What is the name of the data collection system used to study pregnancy outcomes in women with mechanical prosthetic heart valves?

United Kingdom Obstetric Surveillance System

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the data collection system used to study pregnancy outcomes in women with mechanical prosthetic heart valves?. ### Response: United Kingdom Obstetric Surveillance System.

What does UKOSS stand for?

United Kingdom Obstetric Surveillance System

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does UKOSS stand for?. ### Response: United Kingdom Obstetric Surveillance System.

When did BJOG issue 124:1411-9.

2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did BJOG issue 124:1411-9.. ### Response: 2017.

What did van Hagen IM, Roos-Hesselink JW, Ruys TPE, et al. study?

Pregnancy in women with a mechanical heart valve: data of the European Society of Cardi-ology Registry of Pregnancy and Cardiac Disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did van Hagen IM, Roos-Hesselink JW, Ruys TPE, et al. study?. ### Response: Pregnancy in women with a mechanical heart valve: data of the European Society of Cardi-ology Registry of Pregnancy and Cardiac Disease.

What is the European Society of Cardiology Registry of Pregnancy and Cardiac Disease known as?

ROPAC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the European Society of Cardiology Registry of Pregnancy and Cardiac Disease known as?. ### Response: ROPAC.

What is a systematic review and meta-analysis for pregnant women with mechanical heart valves?

Anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a systematic review and meta-analysis for pregnant women with mechanical heart valves?. ### Response: Anticoagulation.

What is the name of the systematic review and meta-analysis of mechanical heart valves?

Anticoagulation for pregnant women

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review and meta-analysis of mechanical heart valves?. ### Response: Anticoagulation for pregnant women.

What is Eur Heart J. 2017:38:1509-16?

Anticoagulation for pregnant women with mechanical heart valves: a systematic review and meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Eur Heart J. 2017:38:1509-16?. ### Response: Anticoagulation for pregnant women with mechanical heart valves: a systematic review and meta-analysis.

What has been shown to be associated with the likelihood of benefit from statin therapy for ASCVD risk reduction?

e605CLINICAL STATEMENTS AND GUIDELINES

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been shown to be associated with the likelihood of benefit from statin therapy for ASCVD risk reduction?. ### Response: e605CLINICAL STATEMENTS AND GUIDELINES.

What has superior discrimination and risk reclassification?

Coronary artery calcium scoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has superior discrimination and risk reclassification?. ### Response: Coronary artery calcium scoring.

What has superior discrimination and risk reclassification as compared with other subclinical imaging mark-ers or biomarkers?

Coronary artery calcium scoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has superior discrimination and risk reclassification as compared with other subclinical imaging mark-ers or biomarkers?. ### Response: Coronary artery calcium scoring.

What was strongly associated with 10-year ASCVD risk in a graded manner across age, sex and racial/ethnic groups?

coronary artery calcium score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was strongly associated with 10-year ASCVD risk in a graded manner across age, sex and racial/ethnic groups?. ### Response: coronary artery calcium score.

What may refine ASCVD risk estimates among lower-risk women?

Coronary artery cal-cium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may refine ASCVD risk estimates among lower-risk women?. ### Response: Coronary artery cal-cium.

What is needed to support its refinement?

more data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is needed to support its refinement?. ### Response: more data.

What is needed to support its use in these subgroups?

more data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is needed to support its use in these subgroups?. ### Response: more data.

A coronary artery calcium score of zero identifies indi-viduals at lower risk of ASCVD events and death over a 10-year period?

statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A coronary artery calcium score of zero identifies indi-viduals at lower risk of ASCVD events and death over a 10-year period?. ### Response: statins.

What do S2.2-15, S2.2-17, and S2.2-25 appear to derive little or no benefit from?

statins for ASCVD risk reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do S2.2-15, S2.2-17, and S2.2-25 appear to derive little or no benefit from?. ### Response: statins for ASCVD risk reduction.

What could reclassify a patient downward into a lower risk group?

absence of coronary artery calcium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could reclassify a patient downward into a lower risk group?. ### Response: absence of coronary artery calcium.

What does the absence of coronary artery calcium not rule out?

noncalcified plaque

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the absence of coronary artery calcium not rule out?. ### Response: noncalcified plaque.

What does not rule out noncalcified plaque?

coronary artery calcium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does not rule out noncalcified plaque?. ### Response: coronary artery calcium.

What might be considered in refining risk for selected low risk adults?

Coronary artery cal-cium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What might be considered in refining risk for selected low risk adults?. ### Response: Coronary artery cal-cium.

What is a history of premature coronary heart disease?

strong family history

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a history of premature coronary heart disease?. ### Response: strong family history.

What are risk estimation tools that incorporate both risk factors and coronary artery calcium for estimating 10-year CHD risk?

S2.2-23 MESAS2.2-28 and Astro-CHARM (Astronaut Cardiovascular Health and Risk Modification)S2.2-29

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are risk estimation tools that incorporate both risk factors and coronary artery calcium for estimating 10-year CHD risk?. ### Response: S2.2-23 MESAS2.2-28 and Astro-CHARM (Astronaut Cardiovascular Health and Risk Modification)S2.2-29.

What is not intended as a “screening” test for all?

Coronary artery calcium measurement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not intended as a “screening” test for all?. ### Response: Coronary artery calcium measurement.

What may be used in select adults to facilitate the clinician-patient risk discussion?

Coronary artery calcium measurement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be used in select adults to facilitate the clinician-patient risk discussion?. ### Response: Coronary artery calcium measurement.

What is the risk of ASCVD for those 40 to 59 years of age?

≥7.5%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of ASCVD for those 40 to 59 years of age?. ### Response: ≥7.5%).

What can be used to estimate a lifetime or 30-year risk of AsCVD?

ACC/AHA 30-year/lifetime risk esti-mator

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be used to estimate a lifetime or 30-year risk of AsCVD?. ### Response: ACC/AHA 30-year/lifetime risk esti-mator.

Younger individuals often have low estimated 10-year risk, but the presence of at least how many major factors is required to have what?

1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Younger individuals often have low estimated 10-year risk, but the presence of at least how many major factors is required to have what?. ### Response: 1.

How many major risk factors are present by middle age?

1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many major risk factors are present by middle age?. ### Response: 1.

What is associated with increased lifetime ASCVD risk and reduced survival free of morbidity compared with those with optimal risk factors?

coronary artery calcium score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with increased lifetime ASCVD risk and reduced survival free of morbidity compared with those with optimal risk factors?. ### Response: coronary artery calcium score.

What is the ACC/AHA 30-year/lifetime risk esti-mator for 20 to 59 years of age?

Calculation of lifetime risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ACC/AHA 30-year/lifetime risk esti-mator for 20 to 59 years of age?. ### Response: Calculation of lifetime risk.

What may be reasonable to consider as a communication strategy for reinforcing adher -ence?

Calculation of lifetime risk with the ACC/AHA 30-year/lifetime risk esti-mator

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be reasonable to consider as a communication strategy for reinforcing adher -ence?. ### Response: Calculation of lifetime risk with the ACC/AHA 30-year/lifetime risk esti-mator.

What is NICE 2018?

What are the Outcomes No of Participants (studies)?

Quality of the evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the Outcomes No of Participants (studies)?. ### Response: Quality of the evidence.

The evidence (GRADE) Anticipated absolute effects Risk with primary +/ - secondary care Risk difference with MDTc (95% CI) Prescribed ACE -I 154 (1 study) 12 months LOWa,b due to risk of bias, imprecision and what else?

indirectness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The evidence (GRADE) Anticipated absolute effects Risk with primary +/ - secondary care Risk difference with MDTc (95% CI) Prescribed ACE -I 154 (1 study) 12 months LOWa,b due to risk of bias, imprecision and what else?. ### Response: indirectness.

Why was LOWa,b downgraded?

risk of bias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was LOWa,b downgraded?. ### Response: risk of bias.

Why was imprecision RR 1.14?

risk of bias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was imprecision RR 1.14?. ### Response: risk of bias.

What was the risk of bias?

VERY LOW

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the risk of bias?. ### Response: VERY LOW.

What percentage of the evidence was at high risk of bias?

majority

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the evidence was at high risk of bias?. ### Response: majority.

How many increments were downgraded if the majority of evidence were at very high risk?

2 increments

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many increments were downgraded if the majority of evidence were at very high risk?. ### Response: 2 increments.

What percentage increments are upgraded when the confidence interval cross 1 MID?

one increment as confidence interval cross 1 MID or 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage increments are upgraded when the confidence interval cross 1 MID?. ### Response: one increment as confidence interval cross 1 MID or 2.

How many increments as the confidence interval crosses both MID and MID?

2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many increments as the confidence interval crosses both MID and MID?. ### Response: 2.

What is the difference between a long MDT clinic and a cardiology clinic?

high risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between a long MDT clinic and a cardiology clinic?. ### Response: high risk.

What is another term for Quality of the evidence?

GRADE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another term for Quality of the evidence?. ### Response: GRADE.

What is the CI for Anticipated absolute effects?

95%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the CI for Anticipated absolute effects?. ### Response: 95%.

How many hospitalisations were there in 1 study?

234

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many hospitalisations were there in 1 study?. ### Response: 234.

What is the risk of bias rate ratio?

0.18

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of bias rate ratio?. ### Response: 0.18.

How many fewer admissions per 100 0?

524

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many fewer admissions per 100 0?. ### Response: 524.

What is LOWa, b due to?

risk of bias, indirectness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is LOWa, b due to?. ### Response: risk of bias, indirectness.

What is the risk of bias in a study?

rate ratio 0

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of bias in a study?. ### Response: rate ratio 0.

How long does it take to get a LOWa, b due to bias?

12 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take to get a LOWa, b due to bias?. ### Response: 12 months.

What is a proxy for Quality of life?

Utility

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a proxy for Quality of life?. ### Response: Utility.

Why is the RR 0.16?

risk of bias, indirectness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is the RR 0.16?. ### Response: risk of bias, indirectness.

What does Utility stand for?

proxy for Quality of life

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Utility stand for?. ### Response: proxy for Quality of life.

What is higher=better?

Utility

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is higher=better?. ### Response: Utility.

How long was the mean utility in the control groups?

0.63

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the mean utility in the control groups?. ### Response: 0.63.

What was the mean utility in the intervention groups?

0.09 higher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean utility in the intervention groups?. ### Response: 0.09 higher.

How much higher was the ACE-I dose prescribed (long acting only)?

210

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much higher was the ACE-I dose prescribed (long acting only)?. ### Response: 210.

Why was MODERATEa due to risk of bias?

rate ratio

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was MODERATEa due to risk of bias?. ### Response: rate ratio.

Why is MODERATEa due to risk of bias?

rate ratio

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is MODERATEa due to risk of bias?. ### Response: rate ratio.

What was the mean ace -i dose prescribed in the control groups?

0.96 to 1.35

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean ace -i dose prescribed in the control groups?. ### Response: 0.96 to 1.35.

All NOACs have some degree of what?

renal elimination

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: All NOACs have some degree of what?. ### Response: renal elimination.

What is the greatest renal dependency for excretion with dabigatran?

80%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the greatest renal dependency for excretion with dabigatran?. ### Response: 80%).

The least withrenal dependency for apixaban is what percentage?

27%).

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The least withrenal dependency for apixaban is what percentage?. ### Response: 27%)..

There are no head-to-head NOAC trials and therefore what should be done?

NOACs should generally not be used

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There are no head-to-head NOAC trials and therefore what should be done?. ### Response: NOACs should generally not be used.

What should treatment be individualized on the basis of?

CrCl

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should treatment be individualized on the basis of?. ### Response: CrCl.

What should the dose adapted according to licensed indications437?

CrCl

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should the dose adapted according to licensed indications437?. ### Response: CrCl.

For mild CKD, what should the clinical decision-making and treatment recommendations match?

thatof patients without CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For mild CKD, what should the clinical decision-making and treatment recommendations match?. ### Response: thatof patients without CKD.

What is a weak recommendation for patients without CKD?

verylow quality evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a weak recommendation for patients without CKD?. ### Response: verylow quality evidence.

What is the low quality of the evidence?

Weak recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the low quality of the evidence?. ### Response: Weak recommendation.

For what stage is oral anticoagulation recommended?

various degrees of renal functionimpairment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For what stage is oral anticoagulation recommended?. ### Response: various degrees of renal functionimpairment.

What is a good quality anticoagulationcontrol?

VKA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a good quality anticoagulationcontrol?. ### Response: VKA.

What is recommended in severe non-dialysis CKD?

using VKAs and selectedNOACs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended in severe non-dialysis CKD?. ### Response: using VKAs and selectedNOACs.

How do we suggest using VKAs and selectedNOACs?

with caution

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do we suggest using VKAs and selectedNOACs?. ### Response: with caution.

What should be used with caution in end-stage renal disease?

VKAs and selectedNOACs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be used with caution in end-stage renal disease?. ### Response: VKAs and selectedNOACs.

What should generally not be used in end stage renal disease with CrCl 15mL/min ordialysis-dependent?

NOACs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should generally not be used in end stage renal disease with CrCl 15mL/min ordialysis-dependent?. ### Response: NOACs.

Where is apixaban 5 mg bid approved for use in AFpatients receiving hemodialysis?

USA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is apixaban 5 mg bid approved for use in AFpatients receiving hemodialysis?. ### Response: USA.

What percentage of TTR is considered ungraded consensus-based?

%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of TTR is considered ungraded consensus-based?. ### Response: %.

What is the name of the drug that is used to monitor renal function in NOAC users?

dabigatran

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug that is used to monitor renal function in NOAC users?. ### Response: dabigatran.

What is a good time to schedule for clinical follow-up?

look for development of new cardiovascular risk factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a good time to schedule for clinical follow-up?. ### Response: look for development of new cardiovascular risk factors.

What is the suggested algorithm for the decision-making process in prescribing OAC therapy in patients with various degrees of renal functionimpairment?

ESRD on RRTFigure 9

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the suggested algorithm for the decision-making process in prescribing OAC therapy in patients with various degrees of renal functionimpairment?. ### Response: ESRD on RRTFigure 9.

What is not available in the United States?

110-mg dose

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not available in the United States?. ### Response: 110-mg dose.

What is preferred unless the patient is elderly or has high bleeding risk?

dabigatran 110 mg bid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is preferred unless the patient is elderly or has high bleeding risk?. ### Response: dabigatran 110 mg bid.

Where is the 110-mg dose not available?

United States

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the 110-mg dose not available?. ### Response: United States.

How many of the doses are available in the US?

75 mg bid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many of the doses are available in the US?. ### Response: 75 mg bid.

What is a system-atic review and meta-analysis of patients with atrial fibrillation and valvular heart disease?

RE-L Y Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a system-atic review and meta-analysis of patients with atrial fibrillation and valvular heart disease?. ### Response: RE-L Y Trial.

What does JAHA stand for?

J Am Heart Assoc

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does JAHA stand for?. ### Response: J Am Heart Assoc.

How does apixaban compare to warfarin?

rivaroxaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does apixaban compare to warfarin?. ### Response: rivaroxaban.

What drug did Bahit use to treat atrial fibrillation and valvular heart disease?

dabigatran

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug did Bahit use to treat atrial fibrillation and valvular heart disease?. ### Response: dabigatran.

What was the name of the trial in which Apixaban was used to reduce stroke and other thromboembolic events in Atrial Fibrillation?

ARISTOTLE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the trial in which Apixaban was used to reduce stroke and other thromboembolic events in Atrial Fibrillation?. ### Response: ARISTOTLE.

When did the ARISTOTLE trial begin?

2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the ARISTOTLE trial begin?. ### Response: 2015.