prognosis/cardio-docs-qa · Datasets at Hugging Face

What is the current status of nicotine addiction therapy?

The past, present, and future

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the current status of nicotine addiction therapy?. ### Response: The past, present, and future.

What is a final recommendation statement of the US Preventive Services Task Force?

Tobacco Smoking Cessation in Adults

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a final recommendation statement of the US Preventive Services Task Force?. ### Response: Tobacco Smoking Cessation in Adults.

In what year was the Cochrane Database Syst Rev published?

2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was the Cochrane Database Syst Rev published?. ### Response: 2012.

S4.5-23. US Preventive Services Task Force. Final Recommendation Statement: Tobacco Smoking Cessation in Adults, Including Pregnant Women: Behavioral and Pharmacotherapy Interventions.

Interventions for smoking cessation in hospitalised patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: S4.5-23. US Preventive Services Task Force. Final Recommendation Statement: Tobacco Smoking Cessation in Adults, Including Pregnant Women: Behavioral and Pharmacotherapy Interventions.. ### Response: Interventions for smoking cessation in hospitalised patients.

What is the name of the TIMI 9A Investigators?

Antman

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the TIMI 9A Investigators?. ### Response: Antman.

What was the safety report from the Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9A trial?

Hirudin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the safety report from the Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9A trial?. ### Response: Hirudin.

How long did it take for Hirudin to be used in acute myocardial infarction?

1624 - 1630

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take for Hirudin to be used in acute myocardial infarction?. ### Response: 1624 - 1630.

What is the name of the Thrombolysis and Thrombin Inhibition in Myocardia 9B trial?

Circulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Thrombolysis and Thrombin Inhibition in Myocardia 9B trial?. ### Response: Circulation.

What is the name of the randomized trial of intravenous heparin versus recombinant hirudin for acute coronary syndromes?

GUSTO IIA Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized trial of intravenous heparin versus recombinant hirudin for acute coronary syndromes?. ### Response: GUSTO IIA Investigators.

What is GUSTO IIa?

Global Use of Strategies to Open Occluded Coronary Arteries

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is GUSTO IIa?. ### Response: Global Use of Strategies to Open Occluded Coronary Arteries.

How many investigators were there in 1994?

61

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many investigators were there in 1994?. ### Response: 61.

What was the total number of investigators?

956 - 961

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the total number of investigators?. ### Response: 956 - 961.

What is a comparison of recombinant hirudin with heparin for the treatment of acute coronary syndromes?

Randomized trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a comparison of recombinant hirudin with heparin for the treatment of acute coronary syndromes?. ### Response: Randomized trial.

What is the Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO)?

IIb investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO)?. ### Response: IIb investigators.

How many ( 11 ): 775 - 782?

335

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many ( 11 ): 775 - 782?. ### Response: 335.

What is used in high-risk coronary angioplasty?

monoclonal antibody

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used in high-risk coronary angioplasty?. ### Response: monoclonal antibody.

The EPIC Investigation uses what antibody?

monoclonal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The EPIC Investigation uses what antibody?. ### Response: monoclonal.

What is the name of the study that investigated platelet glycoprotein IIb/IIIa receptor blockade and low-dose heparin during percutaneous coronary revascularization?

EPILOG Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated platelet glycoprotein IIb/IIIa receptor blockade and low-dose heparin during percutaneous coronary revascularization?. ### Response: EPILOG Investigators.

Low-dose heparin during percutaneous coronary revascularization?

Platelet glycoprotein IIb/IIIa receptor blockade

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Low-dose heparin during percutaneous coronary revascularization?. ### Response: Platelet glycoprotein IIb/IIIa receptor blockade.

N Engl J Med. 1997; 336 ( 24): 1689 - 1696.

1689 - 1696

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: N Engl J Med. 1997; 336 ( 24): 1689 - 1696.. ### Response: 1689 - 1696.

Landefeld CS, Cook EF, et al.

Cook EF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Landefeld CS, Cook EF, et al.. ### Response: Cook EF.

What is a predictor of major bleeding in hospitalized patients starting anticoagu-lant therapy?

preliminary validation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a predictor of major bleeding in hospitalized patients starting anticoagu-lant therapy?. ### Response: preliminary validation.

Who started anticoagu-lant therapy in 1987?

hospitalized patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who started anticoagu-lant therapy in 1987?. ### Response: hospitalized patients.

What is the name of the journal that published 82 ( 4 ): 703-713?

N Engl J Med

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that published 82 ( 4 ): 703-713?. ### Response: N Engl J Med.

What is a bleeding risk index for?

estimating the probability of major bleeding in hospitalized patients starting anticoagulant therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a bleeding risk index for?. ### Response: estimating the probability of major bleeding in hospitalized patients starting anticoagulant therapy.

What is an amjmed index for estimating the probability of major bleeding?

bleeding risk index

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an amjmed index for estimating the probability of major bleeding?. ### Response: bleeding risk index.

What is the weight-based heparin nomogram?

practice guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the weight-based heparin nomogram?. ### Response: practice guideline.

What is a practice guideline?

weight-based heparin nomogram

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a practice guideline?. ### Response: weight-based heparin nomogram.

What is weight-based heparin nomogram as a practice guideline?

The effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is weight-based heparin nomogram as a practice guideline?. ### Response: The effectiveness.

How many ( 15 ): 1645 - 1649?

156

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many ( 15 ): 1645 - 1649?. ### Response: 156.

What is a prospective study of the value of monitoring heparin treatment with the activated par-tial thromboplastin time?

N Engl J Med

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a prospective study of the value of monitoring heparin treatment with the activated par-tial thromboplastin time?. ### Response: N Engl J Med.

Med. 1972 ; 287 ( 7 ): 324 - 327.

N Engl J Med

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Med. 1972 ; 287 ( 7 ): 324 - 327.. ### Response: N Engl J Med.

Bain B, Forster T, Sleigh B. What is the difference between the activated partial thromboplastin time and hisparin?

Heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Bain B, Forster T, Sleigh B. What is the difference between the activated partial thromboplastin time and hisparin?. ### Response: Heparin.

What is the difference between heparin and the activated partial thromboplastin time?

—

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between heparin and the activated partial thromboplastin time?. ### Response: —.

What was Kimberly Henricks on February 10, 2012?

American College of Chest Physicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was Kimberly Henricks on February 10, 2012?. ### Response: American College of Chest Physicians.

What is the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Otto et al 2020 ACC/AHA Guideline for the Management of Valvular Heart DiseaseFebruary 2, 2021 Circulation. 2021;143:e72–e227

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: Otto et al 2020 ACC/AHA Guideline for the Management of Valvular Heart DiseaseFebruary 2, 2021 Circulation. 2021;143:e72–e227.

What is a recommendation for Timing of Intervention for Mixed AS and AR?

AVR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a recommendation for Timing of Intervention for Mixed AS and AR?. ### Response: AVR.

What does Online Data Supplement 33.COR LOE Recommendations1 B-NR1 summarize?

studies that support the recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Online Data Supplement 33.COR LOE Recommendations1 B-NR1 summarize?. ### Response: studies that support the recommendations.

In symptomatic patients with combined AS and AR, what is the peak transvalvular jet velocity of at least 4.0 m/s?

AVR is recommended

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In symptomatic patients with combined AS and AR, what is the peak transvalvular jet velocity of at least 4.0 m/s?. ### Response: AVR is recommended.

What is the mean transvalvular gradient of at least 40 mm Hg?

AVR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the mean transvalvular gradient of at least 40 mm Hg?. ### Response: AVR.

What is SAVR recommended for in asymptomatic patients with combined AS and AR?

jet velocity of ≥4.0 m/s with an LVEF <50%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is SAVR recommended for in asymptomatic patients with combined AS and AR?. ### Response: jet velocity of ≥4.0 m/s with an LVEF <50%,.

What is the peak transvalvular jet velocity of 4.0 m/s?

≥

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the peak transvalvular jet velocity of 4.0 m/s?. ### Response: ≥.

Isolated moderate AS or moderate AR is currently placed in what stage?

Stage B

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Isolated moderate AS or moderate AR is currently placed in what stage?. ### Response: Stage B.

What is Stage B progressive disease for which no therapeutic action is indicated?

isolated moderate AS or moderate AR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Stage B progressive disease for which no therapeutic action is indicated?. ### Response: isolated moderate AS or moderate AR.

Some patients with moderate mixed disease develop symptoms that stem from their valve disease?

LV dysfunction, as evidenced by an LVEF of <50%, and who have no other reason for LV dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Some patients with moderate mixed disease develop symptoms that stem from their valve disease?. ### Response: LV dysfunction, as evidenced by an LVEF of <50%, and who have no other reason for LV dysfunction.

What argument was raised that if there was no AR, the aortic jet velocity and gradient would be what?

correspondingly lower

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What argument was raised that if there was no AR, the aortic jet velocity and gradient would be what?. ### Response: correspondingly lower.

What would not meet the definitions for severe AS?

aortic jet velocity and gradient

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would not meet the definitions for severe AS?. ### Response: aortic jet velocity and gradient.

What would be only moderate AR by defi-nition?

aortic jet velocity and gradient would be correspondingly lower and would not meet the definitions for severe AS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would be only moderate AR by defi-nition?. ### Response: aortic jet velocity and gradient would be correspondingly lower and would not meet the definitions for severe AS.

Recent data suggest that the natural his-tory of moderate mixed disease behaves similarly to that of pure disease?

valve disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Recent data suggest that the natural his-tory of moderate mixed disease behaves similarly to that of pure disease?. ### Response: valve disease.

How does moderate mixed disease compare to pure severe AS1?

similarly

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does moderate mixed disease compare to pure severe AS1?. ### Response: similarly.

What is a similar mortality risk to that of pure severe ass?

moderate mixed disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a similar mortality risk to that of pure severe ass?. ### Response: moderate mixed disease.

How is valve replacement war -ranted for the symptomatic patient if the patient's data meet criteria for severe AS?

AVR is recommended

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is valve replacement war -ranted for the symptomatic patient if the patient's data meet criteria for severe AS?. ### Response: AVR is recommended.

What criteria does TAVI ver -sus SAVR meet for severe AS?

any of the criteria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What criteria does TAVI ver -sus SAVR meet for severe AS?. ### Response: any of the criteria.

What is discussed in Section 3.2.4.2.2?

The decision about whether to proceed with TAVI ver -sus SAVR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is discussed in Section 3.2.4.2.2?. ### Response: The decision about whether to proceed with TAVI ver -sus SAVR.

What is presumed to be the cause of LV dysfunction?

valve disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is presumed to be the cause of LV dysfunction?. ### Response: valve disease.

What is indicated in mixed AS and MRPatients with combined AS and MR?

AVR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is indicated in mixed AS and MRPatients with combined AS and MR?. ### Response: AVR.

What kind of decision-making process is involved in an in-dividual patient?

shared decision-making with the patient

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What kind of decision-making process is involved in an in-dividual patient?. ### Response: shared decision-making with the patient.

What type of AS and primary MR patients are best treated with?

combined

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of AS and primary MR patients are best treated with?. ### Response: combined.

Who makes the decisions for in-diviual patients?

an MDT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who makes the decisions for in-diviual patients?. ### Response: an MDT.

What are patients with severe AS and severe primary MR best treated with?

SAVR and mitral valve surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patients with severe AS and severe primary MR best treated with?. ### Response: SAVR and mitral valve surgery.

What is best treated unless the surgical risk is high or prohibitive?

patients with severe AS and severe primary MR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is best treated unless the surgical risk is high or prohibitive?. ### Response: patients with severe AS and severe primary MR.

A staged procedure with TAVI followed by mitral TEER can be effective if there is severe what?

high or prohibitive surgical risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A staged procedure with TAVI followed by mitral TEER can be effective if there is severe what?. ### Response: high or prohibitive surgical risk.

What can be effective if there is severe AS and severe secondary MR?

SAVR and mitral valve surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be effective if there is severe AS and severe secondary MR?. ### Response: SAVR and mitral valve surgery.

What is Hb A1c?

glycosylat ed haemoglobin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Hb A1c?. ### Response: glycosylat ed haemoglobin.

What is peak flo w or spir ometr y?

urinalysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is peak flo w or spir ometr y?. ### Response: urinalysis.

What should you do when a diagnosis of hear t failure has been made?

assess se verity, aetiology , precipitating f actors, type of car diac dysfunction and correctable causes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should you do when a diagnosis of hear t failure has been made?. ### Response: assess se verity, aetiology , precipitating f actors, type of car diac dysfunction and correctable causes.

What is aetiology, precipitating f actors, type of car diac dysfunction and correctable causes of heart failure?

assess se verity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is aetiology, precipitating f actors, type of car diac dysfunction and correctable causes of heart failure?. ### Response: assess se verity.

What is heart failure caused by?

valve dise

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is heart failure caused by?. ### Response: valve dise.

What is the NICE guideline on hear t valve disease?

1.2.14 When a diagnosis of hear t failure has been made, assess se verity, aetiology , precipitating f actors, type of car diac dysfunction and correctable causes. [2010] Heart failur e caused by valve dise ase 1.2.15 Refer people wit h hear t failure caused b y valve disease f or specialist assessment and advice r egar ding f ollow-up. See t he section on r eferral for echocar diograph y and specialist assessment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the NICE guideline on hear t valve disease?. ### Response: 1.2.14 When a diagnosis of hear t failure has been made, assess se verity, aetiology , precipitating f actors, type of car diac dysfunction and correctable causes. [2010] Heart failur e caused by valve dise ase 1.2.15 Refer people wit h hear t failure caused b y valve disease f or specialist assessment and advice r egar ding f ollow-up. See t he section on r eferral for echocar diograph y and specialist assessment.

What is t he basis f or a hist orical diagnosis of?

hear t failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is t he basis f or a hist orical diagnosis of?. ### Response: hear t failure.

What is a basis for a hist orical diagnosis of hear t failure?

assess se verity, aetiology , precipitating f actors, type of car diac dysfunction and correctable causes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a basis for a hist orical diagnosis of hear t failure?. ### Response: assess se verity, aetiology , precipitating f actors, type of car diac dysfunction and correctable causes.

How can you manage care in accor dance with this guideline only if the diagnosis is confirmed?

Review t he basis f or a hist orical diagnosis of hear t failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How can you manage care in accor dance with this guideline only if the diagnosis is confirmed?. ### Response: Review t he basis f or a hist orical diagnosis of hear t failure.

What should a person have done fur ther in vestigation?

appr opriat

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should a person have done fur ther in vestigation?. ### Response: appr opriat.

Chronic hear t failure in adult s: diagnosis and management (NG106) NICE 2023.

All

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Chronic hear t failure in adult s: diagnosis and management (NG106) NICE 2023.. ### Response: All.

What year is NICE 2023?

Chronic hear t failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year is NICE 2023?. ### Response: Chronic hear t failure.

What is the Subject t o Notice of right s?

All right s reserved

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Subject t o Notice of right s?. ### Response: All right s reserved.

What does VA/DoD CPG f or the Management of Dyslipidemia for Cardiovascular Risk Reduction do?

Primary Prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does VA/DoD CPG f or the Management of Dyslipidemia for Cardiovascular Risk Reduction do?. ### Response: Primary Prevention.

What is the topic sub-topic # Recommendation Strengtha Pharma cotherapy, Supplements, and Nutraceuticals a. Primary Prevention 6. For primary prevention, we recommend offering what?

a moderate -dose statin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the topic sub-topic # Recommendation Strengtha Pharma cotherapy, Supplements, and Nutraceuticals a. Primary Prevention 6. For primary prevention, we recommend offering what?. ### Response: a moderate -dose statin.

What do we recommend for patients with a >12% 10 -year cardiovascular risk?

moderate -dose statin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do we recommend for patients with a >12% 10 -year cardiovascular risk?. ### Response: moderate -dose statin.

What is the l ow-density lipoprotein cholesterol >190 mg/dL?

moderate -dose statin in patients with a >12% 10 -year cardiovascular risk or l ow-density lipoprotein cholesterol >190 mg/dL or diabetes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the l ow-density lipoprotein cholesterol >190 mg/dL?. ### Response: moderate -dose statin in patients with a >12% 10 -year cardiovascular risk or l ow-density lipoprotein cholesterol >190 mg/dL or diabetes.

For primary prevention, what do we suggest offering a moderate -dose statin?

patients with a >12% 10 -year cardiovascular risk or l ow-density lipoprotein cholesterol >190 mg/dL or diabetes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For primary prevention, what do we suggest offering a moderate -dose statin?. ### Response: patients with a >12% 10 -year cardiovascular risk or l ow-density lipoprotein cholesterol >190 mg/dL or diabetes.

What is the recommended dose of a moderate -dose statin for patients with a 10 -year cardiovascular risk between 6% and 12%?

Strong for 7. For primary prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recommended dose of a moderate -dose statin for patients with a 10 -year cardiovascular risk between 6% and 12%?. ### Response: Strong for 7. For primary prevention.

What is a weak for 8?

primary prevention in patients on moderate -dose statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a weak for 8?. ### Response: primary prevention in patients on moderate -dose statins.

For primary prevention in patients on moderate dose statins, what do we suggest against?

maximizing the statin dose

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For primary prevention in patients on moderate dose statins, what do we suggest against?. ### Response: maximizing the statin dose.

Why do we suggest against maximizing the statin dose in patients on moderate -dose statins?

lack of evidence proving added cardiovascular benefits and the risks of higher dose statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why do we suggest against maximizing the statin dose in patients on moderate -dose statins?. ### Response: lack of evidence proving added cardiovascular benefits and the risks of higher dose statins.

What is there insufficient evidence to recommend for or against using for primary prevention?

ezetimibe

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is there insufficient evidence to recommend for or against using for primary prevention?. ### Response: ezetimibe.

What is insufficient evidence to recommend for or against using ezetimibe with or without statins?

primar y prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is insufficient evidence to recommend for or against using ezetimibe with or without statins?. ### Response: primar y prevention.

For primary prevention, we recommend against offering PCSK9 inhibitors due to unknown long-term safety, inconclusive evidence for benefit, and high cost?

10

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For primary prevention, we recommend against offering PCSK9 inhibitors due to unknown long-term safety, inconclusive evidence for benefit, and high cost?. ### Response: 10.

Evidence for benefit and high cost?

inconc lusive

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Evidence for benefit and high cost?. ### Response: inconc lusive.

For secondary prevention, what do we recommend using at least a moderate-dose statin?

Strong for 12

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For secondary prevention, what do we recommend using at least a moderate-dose statin?. ### Response: Strong for 12.

What do we suggest for patients who are willing to intensify treatment?

offering high -dose statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do we suggest for patients who are willing to intensify treatment?. ### Response: offering high -dose statins.

What are high -dose statins supposed to reduce?

non -fatal cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are high -dose statins supposed to reduce?. ### Response: non -fatal cardiovascular events.

What is ezetimibe used for in higher risk patients who are willing to intensify treatment?

secondary prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ezetimibe used for in higher risk patients who are willing to intensify treatment?. ### Response: secondary prevention.

What do we suggest adding to statins for reducing non -fatal cardiovascular events?

ezetimibe

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do we suggest adding to statins for reducing non -fatal cardiovascular events?. ### Response: ezetimibe.

What do we suggest for secondary prevention in higher risk patients who are willing to intensify treatment?

offering high -dose statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do we suggest for secondary prevention in higher risk patients who are willing to intensify treatment?. ### Response: offering high -dose statins.

What is a PCSK9 inhibitor in addition to?

a maximally tolerated statin dose

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a PCSK9 inhibitor in addition to?. ### Response: a maximally tolerated statin dose.

What is a PCSK9 inhibitor in addition to a maximally tolerated statin dose with ezetimibe for reducing non -fatal cardiovascular events?

For secondary prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a PCSK9 inhibitor in addition to a maximally tolerated statin dose with ezetimibe for reducing non -fatal cardiovascular events?. ### Response: For secondary prevention.

A discussion of their uncertain long -term safety, additional benefits, and an exploration of the patient’s values and preferences are what?

risk of high -dose statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A discussion of their uncertain long -term safety, additional benefits, and an exploration of the patient’s values and preferences are what?. ### Response: risk of high -dose statins.

What is weak for c. Other Medications, Supplements, and Nutraceuticals?

15

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is weak for c. Other Medications, Supplements, and Nutraceuticals?. ### Response: 15.

For primary or secondary prevention, what do we recommend against using?

niacin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For primary or secondary prevention, what do we recommend against using?. ### Response: niacin.