prognosis/cardio-docs-qa · Datasets at Hugging Face

What was considered to be preferable to data on heart failure?

Data on all -cause mortality and hospitalisation

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What does FH of-ten go undiagnosed?

S4.4.4.2-2As discussed in these guidelines (Section 4.2.)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does FH of-ten go undiagnosed?. ### Response: S4.4.4.2-2As discussed in these guidelines (Section 4.2.).

Young adults with primary el-evations of LDL-C 190 mg/dl have a long-term ASCVD burden?

S4.4.4.2-3 and statin therapy is recommended

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Young adults with primary el-evations of LDL-C 190 mg/dl have a long-term ASCVD burden?. ### Response: S4.4.4.2-3 and statin therapy is recommended.

What type of screening can identify other family members with elevated LDL-C?

cascade screening

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Even moderate hypercholesterolemia can accelerate development of what?

atherosclerosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Even moderate hypercholesterolemia can accelerate development of what?. ### Response: atherosclerosis.

What should be addressed appropriately?

Sec-ondary causes of elevated cholesterol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be addressed appropriately?. ### Response: Sec-ondary causes of elevated cholesterol.

What suggests genetic forms of hypercholesterolemia?

Elevations of LDL-C persisting af-ter excluding secondary causes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What suggests genetic forms of hypercholesterolemia?. ### Response: Elevations of LDL-C persisting af-ter excluding secondary causes.

Young adults who experience prolonged exposure to hyperlipidemia prior to age 55 are shown to have what?

significantly increased risk of coro-nary heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Young adults who experience prolonged exposure to hyperlipidemia prior to age 55 are shown to have what?. ### Response: significantly increased risk of coro-nary heart disease.

What has significantly increased risk of coro-nary heart disease?

Young adults who experience prolonged exposure to hyperlipidemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has significantly increased risk of coro-nary heart disease?. ### Response: Young adults who experience prolonged exposure to hyperlipidemia.

What has the potential to reduce the hyperlipidemia and associated ASCVD risk factor burden?

Intensive lifestyle change

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has the potential to reduce the hyperlipidemia and associated ASCVD risk factor burden?. ### Response: Intensive lifestyle change.

Young adults with persistent, moderate hypercholesterolemia (LDL-C 160-189 mg/dL) are a smaller group but at what risk?

higher risk

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What is an example of a risk-enhancing factor?

family history of premature AS-CVD

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Why is there an increased probability of genetic FH in this LDL-C range?

clinical judgment would suggest that these high risk young adults will benefit from long-term statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is there an increased probability of genetic FH in this LDL-C range?. ### Response: clinical judgment would suggest that these high risk young adults will benefit from long-term statin therapy.

What type of therapy would high risk young adults benefit from?

statin therapy

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Long-term statin therapy has been shown that those with higher LDL-C can gain as much or more benefit from what?

cholesterol re-duction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Long-term statin therapy has been shown that those with higher LDL-C can gain as much or more benefit from what?. ### Response: cholesterol re-duction.

In young adults without phenotypical severe hy-percholesterolemia, risk assessment should begin by estimation of how many lifetimes?

21 years

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What should risk assessment begin with?

estimation of lifetime risk

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What can be used to estimate lifetime risk starting at age 21 years?

The pooled cohort equations

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To improve high-risk lifestyle behaviors including tobacco use, sedentary lifestyle and/or poor diet?

pooled cohort equations

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When young adults with hyper-cholesterolemia or multiple risk factors are identified, what is indicated?

lifestyle intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When young adults with hyper-cholesterolemia or multiple risk factors are identified, what is indicated?. ### Response: lifestyle intervention.

To date, no long-term RCTs with cholesterol-lowering drugs have been carried out in what age group?

20 to 39 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: To date, no long-term RCTs with cholesterol-lowering drugs have been carried out in what age group?. ### Response: 20 to 39 years.

What is the age range of the primary prevention RCT?

low to moderate short-term risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the age range of the primary prevention RCT?. ### Response: low to moderate short-term risk.

What has been proposed in those younger individuals at low to moderate short-term risk but at high lifetime risk?

a primary prevention RCT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been proposed in those younger individuals at low to moderate short-term risk but at high lifetime risk?. ### Response: a primary prevention RCT.

What would be used to detect significant coronary atherosclerosis with CAC scores?

statins or drug combination

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would be used to detect significant coronary atherosclerosis with CAC scores?. ### Response: statins or drug combination.

What has been suggested for this purpose?

statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been suggested for this purpose?. ### Response: statin therapy.

What does the Department of Veterans Affairs do?

10.1161/CIRCULATIONAHA.120.052209 226

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the Department of Veterans Affairs do?. ### Response: 10.1161/CIRCULATIONAHA.120.052209 226.

What does icosapent ethyl do for hypertriglyceridemia?

Cardiovascular risk reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does icosapent ethyl do for hypertriglyceridemia?. ### Response: Cardiovascular risk reduction.

What is eicosapent ethyl used for?

hypertriglyceridemia

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What is the name of the drug used to treat hypertriglyceridemia?

Medical nutrition therapy

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How many people in Japan have had strokes?

220

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people in Japan have had strokes?. ### Response: 220.

Where is the JELIS Investigators located?

Japan

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What is eicosapentaenoic acid used for in hypercholesterolemic patients?

Reduction in the recurrence of stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is eicosapentaenoic acid used for in hypercholesterolemic patients?. ### Response: Reduction in the recurrence of stroke.

What is the name of the subanalysis of the JELIS trial?

JELIS Investigators, Japan. Reduction in the recurrence of stroke by eicosapentaenoic acid for hypercholesterolemic patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the subanalysis of the JELIS trial?. ### Response: JELIS Investigators, Japan. Reduction in the recurrence of stroke by eicosapentaenoic acid for hypercholesterolemic patients.

How long was the MARINE trial?

12-week

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the MARINE trial?. ### Response: 12-week.

What is the name of the multi-center, plA-cebo-controlled, Randomized, double-blINd, 12-week study with an open-label extension?

MARINE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multi-center, plA-cebo-controlled, Randomized, double-blINd, 12-week study with an open-label extension?. ### Response: MARINE.

When was the Am J Cardiol.108:682-690?

2011

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What is the essential cornerstone for effective treat-ment of “refractory” severe hypertriglyceridemia?

Medical nutrition therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the essential cornerstone for effective treat-ment of “refractory” severe hypertriglyceridemia?. ### Response: Medical nutrition therapy.

What is the essential cornerstone for effective treatment of hypertriglyceridemia?

Medical nutrition therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the essential cornerstone for effective treatment of hypertriglyceridemia?. ### Response: Medical nutrition therapy.

Evidence from a lipid management program.

Eicosapentaenoic acid ethyl ester (AMR101) therapy in patients with very high triglyceride levels (from the Multi-center, plA-cebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension [MARINE] trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Evidence from a lipid management program.. ### Response: Eicosapentaenoic acid ethyl ester (AMR101) therapy in patients with very high triglyceride levels (from the Multi-center, plA-cebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension [MARINE] trial.

What is the name of the randomized clinical trial that evaluated the effect of high-dose omega-3 fatty acids vs corn oil on major adverse cardiovascular events in patients at high cardiovascular risk?

STRENGTH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized clinical trial that evaluated the effect of high-dose omega-3 fatty acids vs corn oil on major adverse cardiovascular events in patients at high cardiovascular risk?. ### Response: STRENGTH.

How many studies have been conducted on the STRENGTH trial?

225

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What does n-3 fatty acid supplements do in elderly patients after myocardial infarc-tion?

Effects

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What is the name of the randomized, controlled trial?

Multi-center, plA-cebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension [MARINE] trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized, controlled trial?. ### Response: Multi-center, plA-cebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension [MARINE] trial.

What is the name of the disease caused by hypertriglyceridemia?

pancreatitis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the disease caused by hypertriglyceridemia?. ### Response: pancreatitis.

What is one of the reasons for the interaction of familial and secondary causes?

role in pancreatitis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the reasons for the interaction of familial and secondary causes?. ### Response: role in pancreatitis.

Who is the author of the paper?

Tanaka K

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Who represents the American Heart Association Clinical Pharmacology Committee of the Council on Clinical Cardiology?

Wiggins BS, Saseen JJ, Page RL 2nd, Reed BN, Sneed K, Kostis JB, Lanfear D, Virani S, Morris PB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who represents the American Heart Association Clinical Pharmacology Committee of the Council on Clinical Cardiology?. ### Response: Wiggins BS, Saseen JJ, Page RL 2nd, Reed BN, Sneed K, Kostis JB, Lanfear D, Virani S, Morris PB.

Who represents Council on Hypertension?

American Heart Association Clinical Pharmacology Committee of the Council on Clinical Cardiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who represents Council on Hypertension?. ### Response: American Heart Association Clinical Pharmacology Committee of the Council on Clinical Cardiology.

Who is Professor of Medicine, Division of Cardiology, Medical Director for Quality, Vanderbilt Heart & Vascular Institute, and Associate Medical Director, Cardiovascular ICUN?

Sidney C. Smith Jr

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Professor of Medicine, Division of Cardiology, Medical Director for Quality, Vanderbilt Heart & Vascular Institute, and Associate Medical Director, Cardiovascular ICUN?. ### Response: Sidney C. Smith Jr.

What is the name of the professor of medicine at the University of North Carolina, Chapel Hill?

Sidney C. Smith Jr

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Who is Professor of Cardiovascular Research at Baylor College of Medicine?

Salim S. Virani

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Professor of Cardiovascular Research at Baylor College of Medicine?. ### Response: Salim S. Virani.

What is Michael E. DeBakey VA Medical Center's job title?

Staff Cardiologist and Investigator

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What is the name of the professor and chief of Rush Medical College?

Kim A. Williams Sr Rush Medical College—James B. Herrick

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When was this article downloaded?

May 1, 2023

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What is the Incremental value of the exercise test for diagnosing the presence or absence of coronary artery disease?

EstimatingPretest Probability

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Incremental value of the exercise test for diagnosing the presence or absence of coronary artery disease?. ### Response: EstimatingPretest Probability.

When did Diamond GA, Forrester JS, Hirsch M, et al. apply conditionalprobability analysis to the clinical diagnosis of CAD?

1985

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Diamond GA, Forrester JS, Hirsch M, et al. apply conditionalprobability analysis to the clinical diagnosis of CAD?. ### Response: 1985.

What is a low diagnostic yield of elective coronaryangiography?

Diamond GA, Kaul S. Low diagnostic yield of elective coronaryangiography. N Engl J Med. 2010;363:93–5.91

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a low diagnostic yield of elective coronaryangiography?. ### Response: Diamond GA, Kaul S. Low diagnostic yield of elective coronaryangiography. N Engl J Med. 2010;363:93–5.91.

What is an alternative diag nosticstrategies for coronary artery disease?

Tradi-tional Age, Sex, and Angina Typicality-Based Approach for EstimatingPretest Probability of Angiographically Significant Coronary ArteryDisease in Patients Undergoing Coronary Computed TomographicAngiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an alternative diag nosticstrategies for coronary artery disease?. ### Response: Tradi-tional Age, Sex, and Angina Typicality-Based Approach for EstimatingPretest Probability of Angiographically Significant Coronary ArteryDisease in Patients Undergoing Coronary Computed TomographicAngiography.

What is low diagnostic yield of elective coronaryangiography?

Low diagnostic yield of elective coronaryangiography. N Engl J Med. 2010;363:93–5.91

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is low diagnostic yield of elective coronaryangiography?. ### Response: Low diagnostic yield of elective coronaryangiography. N Engl J Med. 2010;363:93–5.91.

What is exercise echocardiography or exercise SPECT imaging?

A meta-analysis of diagnostictest performance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is exercise echocardiography or exercise SPECT imaging?. ### Response: A meta-analysis of diagnostictest performance.

What are the results from the Multinational Coronary CTAngiography Evaluation for Clinical Outcomes: An International Mul-ticenter Registry?

Angiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results from the Multinational Coronary CTAngiography Evaluation for Clinical Outcomes: An International Mul-ticenter Registry?. ### Response: Angiography.

What is the name of the journal that studies the risks of cancer from computed tomographic scans in the United States in 2007?

Arch Intern Med.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that studies the risks of cancer from computed tomographic scans in the United States in 2007?. ### Response: Arch Intern Med..

What year did the Arch Intern Med publish a report on cancer risks?

2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did the Arch Intern Med publish a report on cancer risks?. ### Response: 2009.

How did Gerber TC, Gibbons RJ weigh the risks and benefits of cardiac imaging with ionizing radiation?

Weighing the risks and benefits

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Gerber TC, Gibbons RJ weigh the risks and benefits of cardiac imaging with ionizing radiation?. ### Response: Weighing the risks and benefits.

What is ionizing radiation used for in cardiac imaging?

a science advisory

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ionizing radiation used for in cardiac imaging?. ### Response: a science advisory.

What is the risk of myocardial perfusion scans in the United States?

projected population cancer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of myocardial perfusion scans in the United States?. ### Response: projected population cancer.

What does Abbara S, Chen MY, et al. say about SCCT guidelines on radiation dose and dose-optimization strategies in cardiovascular CT?

Halliburton SS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Abbara S, Chen MY, et al. say about SCCT guidelines on radiation dose and dose-optimization strategies in cardiovascular CT?. ### Response: Halliburton SS.

What does Cerqueira MD, Allman KC, Ficaro EP, and others say about radiation exposure in myocardial perfusion imaging?

Recommendations forreducing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Cerqueira MD, Allman KC, Ficaro EP, and others say about radiation exposure in myocardial perfusion imaging?. ### Response: Recommendations forreducing.

What is ionizing radiation used for in cardiacimaging?

a science advisory

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ionizing radiation used for in cardiacimaging?. ### Response: a science advisory.

What is the name of the committee on Cardiac Imaging of the Council on Clinical Cardiology?

Committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the committee on Cardiac Imaging of the Council on Clinical Cardiology?. ### Response: Committee.

What is the name of the multicenter trial of high-speedversus conventional single-photon emission computed tomo graphyimaging?

Multinational Coronary CTAngiography Evaluation for Clinical Outcomes: An International Mul-ticenter Registry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multicenter trial of high-speedversus conventional single-photon emission computed tomo graphyimaging?. ### Response: Multinational Coronary CTAngiography Evaluation for Clinical Outcomes: An International Mul-ticenter Registry.

What are the quantitative results of myocardial perfusion and left ventricular function?

Multicenter trial of high-speedversus conventional single-photon emission computed tomo graphyimaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the quantitative results of myocardial perfusion and left ventricular function?. ### Response: Multicenter trial of high-speedversus conventional single-photon emission computed tomo graphyimaging.

When was the J Am Coll Cardiol 55:1965–74.100?

2010

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What is the name of the 2021 guideline for the secondary prevention of Ischemic Stroke?

GUIDELINESKleindorfer et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2021 guideline for the secondary prevention of Ischemic Stroke?. ### Response: GUIDELINESKleindorfer et al.

What does not support a causal association with increased risk of thromboembolism?

disk aortic valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does not support a causal association with increased risk of thromboembolism?. ### Response: disk aortic valve replacement.

There is no conclusive evidence supporting a causal association between native aortic valve disease and increased risk of stroke or TIA.

478,479

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There is no conclusive evidence supporting a causal association between native aortic valve disease and increased risk of stroke or TIA.. ### Response: 478,479.

What are additional distinct valvular lesions such as Libman-Sacks endocarditis?

486 age-related calcifications,487 or bicuspid aortic valves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are additional distinct valvular lesions such as Libman-Sacks endocarditis?. ### Response: 486 age-related calcifications,487 or bicuspid aortic valves.

Alter-related calcifications and what other lesions have been associated with higher risk of thromboembolism?

bicuspid aortic valves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Alter-related calcifications and what other lesions have been associated with higher risk of thromboembolism?. ### Response: bicuspid aortic valves.

No properly designed trial has addressed the optimal therapeutic strategy to prevent ischemic stroke or what other condition?

TIA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No properly designed trial has addressed the optimal therapeutic strategy to prevent ischemic stroke or what other condition?. ### Response: TIA.

No spe-cific management recommendations can be made for what conditions?

Libman-Sacks endocarditis,486 age-related calcifications,487 or bicuspid aortic valves487 have been associated with increased risk of thromboembolism, although no properly designed trial has addressed the optimal therapeutic strategy to prevent ischemic stroke or TIA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No spe-cific management recommendations can be made for what conditions?. ### Response: Libman-Sacks endocarditis,486 age-related calcifications,487 or bicuspid aortic valves487 have been associated with increased risk of thromboembolism, although no properly designed trial has addressed the optimal therapeutic strategy to prevent ischemic stroke or TIA.

What can be used in patients undergoing bioprosthetic mitral or aortic valve replacement surgery?

oral anticoagulation with warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be used in patients undergoing bioprosthetic mitral or aortic valve replacement surgery?. ### Response: oral anticoagulation with warfarin.

What is the target INR for bioprosthetic mitral or aortic valve replacement surgery?

2.5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the target INR for bioprosthetic mitral or aortic valve replacement surgery?. ### Response: 2.5.

How long is oral anticoagulation with warfarin reasonable for?

at least 3 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is oral anticoagulation with warfarin reasonable for?. ### Response: at least 3 months.

What is a recommendation based on?

the results of observational studies that have reported an increased risk of ischemic stroke early after surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a recommendation based on?. ### Response: the results of observational studies that have reported an increased risk of ischemic stroke early after surgery.

What is the recommended dose of aspirin after 3 to 6 months after surgery?

75 to 100 mg daily

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recommended dose of aspirin after 3 to 6 months after surgery?. ### Response: 75 to 100 mg daily.

Patients with a history of ischemic stroke are advised to take what?

aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with a history of ischemic stroke are advised to take what?. ### Response: aspirin.

How much antiplatelet therapy is recommended for patients with TIA before the bioprosthetic valve surgery?

75 to 100 mg daily

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much antiplatelet therapy is recommended for patients with TIA before the bioprosthetic valve surgery?. ### Response: 75 to 100 mg daily.

What should patients continue to be managed with after the bioproperty valve insertion?

antiplatelet therapy alone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients continue to be managed with after the bioproperty valve insertion?. ### Response: antiplatelet therapy alone.

How should patients with mechanical prosthetic prosthetics be treated?

higher risk of thromboembolic complications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How should patients with mechanical prosthetic prosthetics be treated?. ### Response: higher risk of thromboembolic complications.

What does effective antithrombotic therapy require in patients with mechanical prosthetic heart valves?

effective warfarin anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does effective antithrombotic therapy require in patients with mechanical prosthetic heart valves?. ### Response: effective warfarin anticoagulation.

What does continuous effective warfarin anticoagulation with an INR in the target range require?

effective antithrombotic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does continuous effective warfarin anticoagulation with an INR in the target range require?. ### Response: effective antithrombotic therapy.

How has ACC/AHA guidance been published in separate guidelines?

33

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How has ACC/AHA guidance been published in separate guidelines?. ### Response: 33.

What is the INR of anticoagulation with warfarin?

2.5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the INR of anticoagulation with warfarin?. ### Response: 2.5.

What is recommended for patients with mechanical bileaflet or current-generation single-tilting-disk aortic valve replacement and no risk factors for thromboembolism?

Anticoagulation with warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended for patients with mechanical bileaflet or current-generation single-tilting-disk aortic valve replacement and no risk factors for thromboembolism?. ### Response: Anticoagulation with warfarin.

What are patients with aortic mechanical prosthesis who have a history of ischemic stroke or TIA at higher risk of?

thromboembolic complications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patients with aortic mechanical prosthesis who have a history of ischemic stroke or TIA at higher risk of?. ### Response: thromboembolic complications.

What is recommended to maintain the INR at a higher target of 3.0 (range, 2.5–3.5) or to add aspirin 75 to 100 mg daily?

Anticoagulation with warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended to maintain the INR at a higher target of 3.0 (range, 2.5–3.5) or to add aspirin 75 to 100 mg daily?. ### Response: Anticoagulation with warfarin.

What is the most frequent and severe extracardiac complications of IE?

Neurological complications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most frequent and severe extracardiac complications of IE?. ### Response: Neurological complications.

What is an estimated incidence of up to 20% to 40%?

Neurological complications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an estimated incidence of up to 20% to 40%?. ### Response: Neurological complications.

Ischemic cerebrovascular events represent what type of event?

the most com-

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Ischemic cerebrovascular events represent what type of event?. ### Response: the most com-.

Meschia et al Guidelines for the Primary Prevention of Stroke 3819 433. Francescone S, Halperin JL. What is the risk of antithrombotic therapy for patients with atrial fibrillation?

Balancing the risks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Meschia et al Guidelines for the Primary Prevention of Stroke 3819 433. Francescone S, Halperin JL. What is the risk of antithrombotic therapy for patients with atrial fibrillation?. ### Response: Balancing the risks.