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It is also fairly rambling: for example, lines 95-106 could be removed, Answer:
| null | null |
Also the diagram does not indicate whether the ribozymes are made by the cycle.
| null | null |
life6030029_makarova
| 0 |
Reviewer 2 According to the abstract, this manuscript covers a number of different areas relating to the RNA world hypothesis, including its compatibility with (likely) primitive Earth conditions; the likely characteristics of an RNA world; and, finally, the relationship between an early life-like RNA world system(s) and other life-like systems.
| null | null |
For example there must be ways of making nucleotides from scratch.
| null | null |
life6030029_makarova
| 0 |
It is also fairly rambling: for example, lines 95-106 could be removed, Answer:
| null | null |
Author Response Author Response File: Author Response.pdf
| null | null |
life6030029_makarova
| 0 |
The issue for the origin of life is how to get to a prokaryote.
| null | null |
Maybe there is some slightly different environment that we would still call hydrothermal in which RNA is sufficiently stable.
| null | null |
life6030029_perova
| 0 |
These issues need to be considered separately.
| null | null |
Statements such as in line 232: "the first step is to limit the characteristics of life-like systems into life on Earth" leave one scratching ones head.
| null | null |
life6030029_perova
| 0 |
Was there a way of reproducibly making the same amino acid sequence without translating it from RNA?
| null | null |
But several questions still remain - were there long peptides before long RNA strands?
| null | null |
life6030029_perova
| 0 |
The citations 52 and 53 are in fields that are not related to biology and origin of life.
| null | null |
This section seems to mix up two important questions.
| null | null |
life6030029_perova
| 0 |
These issues need to be considered separately.
| null | null |
Author Response Author Response File: Author Response.pdf
| null | null |
life6030029_perova
| 0 |
The second point is that the paper contains too many errors.
| null | null |
Author Response Author Response File: Author Response.pdf
| null | null |
life6030029_perova
| 0 |
There may be a link from one gene to one protein, but one protein is not really a phenotype.
| null | null |
Author Response Author Response File: Author Response.pdf
| null | null |
life6030029_perova
| 0 |
One example obvious to me is the reference to one of my papers [ref.
| null | null |
The conclusion comes back to the point about primitive Earth environment.
| null | null |
life6030029_perova
| 0 |
It would seem difficult to evolve two separate ribozyme functions at the same time.
| null | null |
It is only when we get to paragraph 3.1 that we get to the point of the article.
| null | null |
life6030029_perova
| 0 |
Another interesting idea that is also raised is the possible importance of RNA solubility at high temperatures, though it does seem that the author is battling nobly (if possibly in vain) to reconcile the RNA world hypothesis with a hydrothermal vent origin of life scenario.
| null | null |
Are you saying a cell interacts with the environment but a single gene does not?
| null | null |
life6030029_perova
| 0 |
The issue for the origin of life is how to get to a prokaryote.
| null | null |
One example obvious to me is the reference to one of my papers [ref.
| null | null |
life6030029_perova
| 0 |
(ii) Do we need the RNA system to be enclosed in a cell membrane or other kind of compartment?
| null | null |
According to the abstract, this manuscript covers a number of different areas relating to the RNA world hypothesis, including its compatibility with (likely) primitive Earth conditions; the likely characteristics of an RNA world; and, finally, the relationship between an early life-like RNA world system(s) and other life-like systems.
| null | null |
life6030029_perova
| 0 |
If so, can RNA control the growth and division of the membrane?
| null | null |
Can we not have an RNA polymerase that uses other copies of itself as a template?
| null | null |
life6030029_perova
| 0 |
If so, can RNA control the growth and division of the membrane?
| null | null |
These issues need to be considered separately.
| null | null |
life6030029_perova
| 0 |
It is only mentioned in the introduction and conclusions.
| null | null |
Author Response Author Response File: Author Response.pdf
| null | null |
life6030029_perova
| 0 |
There are just a few issues that the authors should take into account for further improving their paper prior to acceptance: 1) For several references, the text "Error!
| null | null |
The article contains many original results of undeniable practical significance.
| null | null |
ma15051691_makarova
| 0 |
Author Response Reviewer #2 (Comments to the Author): This manuscript relates to the effect of dysprosium substitution in Ce:YIG thin films and in particular to the temperature dependance of their Faraday rotation.
| null | null |
There are several questions about the content of the article.
| null | null |
ma15051691_makarova
| 0 |
We answer the reviewer’s questions as follows.
| null | null |
demonstrate a temperature stable magneto-optical material Dy2Ce1Fe5O12 for silicon integrated nonreciprocal photonic device applications.
| null | null |
ma15051691_makarova
| 0 |
The saturation magnetization of rare-earth doped YIG affects the Faraday rotation angle. Sayetat et al. and Ostorero et al.
| null | null |
demonstrate a temperature stable magneto-optical material Dy2Ce1Fe5O12 for silicon integrated nonreciprocal photonic device applications.
| null | null |
ma15051691_makarova
| 0 |
1) It is not indicated in the introduction whether any alternative to thin films of yttrium iron garnet is currently being considered for use as magneto-optical resonators. 2) How will the temperature dependence of the Faraday rotation hysteresis loops of Dy:CeYIG thin films change when moving to another wavelength range?
| null | null |
We answer the reviewer’s questions as follows.
| null | null |
ma15051691_makarova
| 0 |
Please check with the editor if this can be fixed.
| null | null |
2) In equation (2) and the following line, there are inconcistencies in the use of capital letters for the Faraday rotation angles.
| null | null |
ma15051691_makarova
| 0 |
The article contains many original results of undeniable practical significance.
| null | null |
It is shown that integrated MO isolators consist of Dy:CeIG thin films show better temperature stability compared to Ce:YIG based devices in the temperature range of 23 ℃ to 70 ℃.
| null | null |
ma15051691_makarova
| 0 |
It is in general well written and the work deserves publication.
| null | null |
Ostorero, J.; Escorne, M.; Pecheron‐Guegan, A.; Soulette, F.; Le Gall, H. Dy3Fe5O12 garnet thin films grown from sputtering of metallic targets.
| null | null |
ma15051691_makarova
| 0 |
Can you explain why an increase in scattering intensity indicates increase in more small voids rather than an increase in existing void sizes?
| null | null |
It indeed the case, but I could not find any discussion on this issue.
| null | null |
ma15124258_makarova
| 0 |
Every available suggestion has been answered carefully and corrected in the article.
| null | null |
-CL-20 crystal form is 622.7 nm-3 -CL-20 is 584.8 nm-3, while the electron density of GPL107 is 571.7 nm-3” You need to specify the reference in which this data were obtained.
| null | null |
ma15124258_makarova
| 0 |
Are the onsets and finishing of the phase transformations consistent with the DSC measurements?
| null | null |
How are the cracks differentiated from the voids?
| null | null |
ma15124258_makarova
| 0 |
How are the cracks differentiated from the voids?
| null | null |
“The electron density of ε-CL-20 crystal form is 622.7 nm-3 and that of γ-CL-20 is 584.8 nm-3, while the electron density of GPL107 is 571.7 nm-3” You need to specify the reference in which this data were obtained.
| null | null |
ma15124258_makarova
| 0 |
Are the onsets and finishing of the phase transformations consistent with the DSC measurements?
| null | null |
I had several questions regarding this work: 1.
| null | null |
ma15124258_makarova
| 0 |
Materials and instruments, you need to specify the particle size of the initial CL-20 powders.
| null | null |
In this paper, the same method was used to calculate the specific surface area and volume fraction, so we did not repeat how to calculator, just added the reference in the manuscript.
| null | null |
ma15124258_makarova
| 0 |
The nano-scale defects were studied by using Wide Angle X-ray Scattering (WAXS) and Small Angle X-ray Scattering (SAXS), during the temperature range from 30 °C to 200 °C .
| null | null |
As you can tell by these questions, my main issue is related to the specific form of the thermal damage.
| null | null |
ma15124258_makarova
| 0 |
I recommend publishing the manuscript after minor the revision.
| null | null |
Could computed microtomography be used to confirm some of the experimental results?
| null | null |
ma15124258_makarova
| 0 |
Some changes in propagation of pores caused by both the phase transitions and temperature were observed by an appropriate experimental technique.
| null | null |
How do these experiments differentiate between increasing the number of defects and the size of the defects?
| null | null |
ma15124258_makarova
| 0 |
The conclusion must be supplemented with a forecast about the change in the performance of the CL-20 in terms of safety and suitability for use after temperature effects.
| null | null |
The DSC curve of CL-20 powders during thermal process Question 5.
| null | null |
ma15124258_makarova
| 0 |
The authors used both WAXS and SAXS to examine CL-20 particles as they were heated from room temperature to around 200C.
| null | null |
If so, do the decomposition products form bubbles in your solvent?
| null | null |
ma15124258_makarova
| 0 |
“During the thermal treatment, the nano-scale pores increase obviously, which will seriously increase the sensitivity of CL-20, and make a dangerous to the explosive charges with CL-20.
| null | null |
To improve the application performance of CL-20, we should try to avoid the increase of such defects, such as storing in an constant low temperature to avoid the thermal expansion, and avoid any phase transition.”
| null | null |
ma15124258_makarova
| 0 |
Response to Reviewer' Comments Dear Reviewer, We sincerely appreciate your comments and suggestions on the manuscript!
| null | null |
The manuscript is devoted to research on the phase transformations of CL-20 at various temperatures.
| null | null |
ma15124258_makarova
| 0 |
“During the thermal treatment, the nano-scale pores increase obviously, which will seriously increase the sensitivity of CL-20, and make a dangerous to the explosive charges with CL-20.
| null | null |
What do you mean by “are calculated” on line 199?
| null | null |
ma15124258_makarova
| 0 |
I recommend publishing the manuscript after minor the revision.
| null | null |
The authors present an experimental study of nano-scale defects in CL-20 under heating.
| null | null |
ma15124258_makarova
| 0 |
Do you have another proof for your conclusions.
| null | null |
Thus, I can recommend it for publication after a minor revision.
| null | null |
ma15124258_makarova
| 0 |
What are the basic equations and assumptions for this calculation?
| null | null |
199-198 “The specific surface area and volume fraction of pores are calculated, and the results are shown in figure 7.” From the text of the manuscript it is not clear what method was used to obtain the calculated data on the specific surface area and volume fraction of pores.
| null | null |
ma15124258_makarova
| 0 |
How do these experiments differentiate between increasing the number of defects and the size of the defects?
| null | null |
Could computed microtomography be used to confirm some of the experimental results?
| null | null |
ma15124258_perova
| 0 |
), we described in detail how to calculate the specific surface area and volume fraction.
| null | null |
Can you explain why an increase in scattering intensity indicates increase in more small voids rather than an increase in existing void sizes?
| null | null |
ma15124258_perova
| 0 |
Review of the manuscript Investigation on the Evolution of Nano-scale Defects of CL-20 Crystals under Thermal Treatment by Wide/Small-Angle X-ray Scattering, Haobin Zhang, Hongfan Wang … The manuscript is devoted to research on the phase transformations of CL-20 at various temperatures.
| null | null |
The conclusion must be supplemented with a forecast about the change in the performance of the SL-20 in terms of safety and suitability for use after temperature effects.
| null | null |
ma15124258_perova
| 0 |
Therefore, I suggest include some comments on this and, probably, provide some discussion of how to avoid the increase of such defects, which increase sensitivity of energetic crystals, in particular CL-20.
| null | null |
As you can tell by these questions, my main issue is related to the specific form of the thermal damage.
| null | null |
ma15124258_perova
| 0 |
), we described in detail how to calculate the specific surface area and volume fraction.
| null | null |
Overall, the work is done well and manuscript sounds.
| null | null |
ma15124258_perova
| 0 |
Do you have another proof for your conclusions.
| null | null |
The nano-scale defects were studied by using Wide Angle X-ray Scattering (WAXS) and Small Angle X-ray Scattering (SAXS), during the temperature range from 30 °C to 200 °C .
| null | null |
ma15124258_perova
| 0 |
Could the increase be due to larger defects rather than an increase in the number of defects?
| null | null |
To improve the application performance of CL-20, we should try to avoid the increase of such defects, such as storing in an constant low temperature to avoid the thermal expansion, and avoid any phase transition.”
| null | null |
ma15124258_perova
| 0 |
Review of article entitled: “Investigation on the Evolution of Nano-scale Defects of CL-20 2 Crystals under Thermal Treatment by Wide/Small-Angle X-ray 3 Scattering” Overall, I liked the paper and believe it contributes to our knowledge of thermal evolution of CL-20.
| null | null |
Or, is it the volume of the defect that is increasing?
| null | null |
ma15124258_perova
| 0 |
Could there be any other explanation rather than increase in number of internal nano-scale pores?
| null | null |
Are the onsets and finishing of the phase transformations consistent with the DSC measurements?
| null | null |
ma15124258_perova
| 0 |
The manuscript is devoted to research on the phase transformations of CL-20 at various temperatures.
| null | null |
In this paper, the same method was used to calculate the specific surface area and volume fraction, so we did not repeat how to calculator, just added the reference in the manuscript.
| null | null |
ma15124258_perova
| 0 |
I recommend publishing the manuscript after minor the revision.
| null | null |
Are the onsets and finishing of the phase transformations consistent with the DSC measurements?
| null | null |
ma15124258_perova
| 0 |
The nano-scale defects were studied by using Wide Angle X-ray Scattering (WAXS) and Small Angle X-ray Scattering (SAXS), during the temperature range from 30 °C to 200 °C .
| null | null |
How do these experiments differentiate between increasing the number of defects and the size of the defects?
| null | null |
ma15124258_perova
| 0 |
The nano-scale defects were studied by using Wide Angle X-ray Scattering (WAXS) and Small Angle X-ray Scattering (SAXS), during the temperature range from 30 °C to 200 °C .
| null | null |
Every available suggestion has been answered carefully and corrected in the article.
| null | null |
ma15124258_perova
| 0 |
The conclusion must be supplemented with a forecast about the change in the performance of the SL-20 in terms of safety and suitability for use after temperature effects.
| null | null |
Review of the manuscript Investigation on the Evolution of Nano-scale Defects of CL-20 Crystals under Thermal Treatment by Wide/Small-Angle X-ray Scattering, Haobin Zhang, Hongfan Wang … The manuscript is devoted to research on the phase transformations of CL-20 at various temperatures.
| null | null |
ma15124258_perova
| 0 |
Overall, the work is done well and manuscript sounds.
| null | null |
Materials and instruments, you need to specify the particle size of the initial CL-20 powders.
| null | null |
ma15124258_perova
| 0 |
To improve the application performance of CL-20, we should try to avoid the increase of such defects, such as storing in an constant low temperature to avoid the thermal expansion, and avoid any phase transition.”
| null | null |
), we described in detail how to calculate the specific surface area and volume fraction.
| null | null |
ma15124258_perova
| 0 |
The authors used both WAXS and SAXS to examine CL-20 particles as they were heated from room temperature to around 200C.
| null | null |
Could computed microtomography be used to confirm some of the experimental results?
| null | null |
ma15124258_perova
| 0 |
Is the omission of any items referring to experience/use of eCigarette/vaping.
| null | null |
The link between smoking and reduced life expectancy has been shown to be causal.
| null | null |
medicina58040502_makarova
| 0 |
Response to Reviewer 1 I would like to thank Reviewer 1 for very detailed and useful comments which will definitely improve our manuscript.
| null | null |
The results section is too extensive - please avoid describing all the results in the text.
| null | null |
medicina58040502_makarova
| 0 |
The results section is too extensive - please avoid describing all the results in the text.
| null | null |
Response to Reviewer 1 I would like to thank Reviewer 1 for very detailed and useful comments which will definitely improve our manuscript.
| null | null |
medicina58040502_makarova
| 0 |
This is a well-designed and executed survey of university cigarette smoking in a country with above-average poverty.
| null | null |
The link between smoking and reduced life expectancy has been shown to be causal.
| null | null |
medicina58040502_makarova
| 0 |
Medicina 2021, 57, x. https://doi.org/10.3390/xxxxx Academic Editor: Firstname Lastname Received: date Accepted: date Published: date Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.
| null | null |
Lack of analysis of second-hand smoke exposure.
| null | null |
medicina58040502_makarova
| 0 |
This is a well-designed and executed survey of university cigarette smoking in a country with above-average poverty.
| null | null |
In Table 5 please provide thr number of subjects (n=.....) Response 5.
| null | null |
medicina58040502_makarova
| 0 |
Author Response Please see the attachment Author Response File: Author Response.pdf
| null | null |
The link between smoking and reduced life expectancy has been shown to be causal.
| null | null |
medicina58040502_makarova
| 0 |
Author Response Please see the attachment Author Response File: Author Response.pdf
| null | null |
This is the opposite of health promotion one expects from all healthcare providers - especially physicians.
| null | null |
medicina58040502_makarova
| 0 |
Author Response Please see the attachment Author Response File: Author Response.pdf
| null | null |
Results were consistent with previous studies of similar target populations.
| null | null |
medicina58040502_makarova
| 0 |
Thus, exposure alone offers little information about the role of second-hand smoke and "contagion."
| null | null |
Thus, exposure alone offers little information about the role of second-hand smoke and "contagion."
| null | null |
medicina58040502_makarova
| 0 |
The study aim should be more precise "The aim of this study was...." Response 1.
| null | null |
Please provide practical implications of this study Response 7.
| null | null |
medicina58040502_makarova
| 0 |
Response to Reviewer 2 I would like to thank Reviewer 2 for very detailed and useful comments which will definitely improve our manuscript.
| null | null |
Tables 6 and 7 are unclear and should be more precise (Especially confidence intervals) Response 6.
| null | null |
medicina58040502_perova
| 0 |
Healthcare providers who smoke provide a bad example to their patients - giving the impression that smoking is not dangerous.
| null | null |
Study sample - please provide more precise data on population (faculties at the university and its share in the total sample of recruited subjects) Response 2.
| null | null |
medicina58040502_perova
| 0 |
Please attach an English version of the questionnaire as supplementary material or precisely describe questions that were used to assess the smoking status.
| null | null |
Medicina 2021, 57, x. https://doi.org/10.3390/xxxxx Academic Editor: Firstname Lastname Received: date Accepted: date Published: date Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.
| null | null |
medicina58040502_perova
| 0 |
Please provide the most important results in the text, and the rest of them are present in Tables.
| null | null |
Results were consistent with previous studies of similar target populations.
| null | null |
medicina58040502_perova
| 0 |
This is contrary to accepted public health policy internationally.
| null | null |
Specifically, whether exposure increases risk of smoking.
| null | null |
medicina58040502_perova
| 0 |
It is likely that students who smoke actively seek roommates who smoke, and students who do not smoke seek roommates who do not smoke.
| null | null |
Author Response Please see the attachment Author Response File: Author Response.docx
| null | null |
medicina58040502_perova
| 0 |
Thus it is unclear if students may be nicotine addicting by alternative means to tobacco smoking.
| null | null |
Finally, I found it disturbing that medical school faculty tolerate student smoking at all.
| null | null |
medicina58040502_perova
| 0 |
In Table 5 please provide thr number of subjects (n=.....) Response 5.
| null | null |
Response to Reviewer 2 I would like to thank Reviewer 2 for very detailed and useful comments which will definitely improve our manuscript.
| null | null |
medicina58040502_perova
| 0 |
This is a well-designed and executed survey of university cigarette smoking in a country with above-average poverty.
| null | null |
Author Response Please see the attachment Author Response File: Author Response.docx
| null | null |
medicina58040502_perova
| 0 |
Is the omission of any items referring to experience/use of eCigarette/vaping.
| null | null |
This result calls into question the university's curriculum addressing the very many diseases associated with tobacco smoking - most of which reduce life expectancy.
| null | null |
medicina58040502_perova
| 0 |
Please provide practical implications of this study Response 7.
| null | null |
This is the opposite of health promotion one expects from all healthcare providers - especially physicians.
| null | null |
medicina58040502_perova
| 0 |
I suggest bringing this result up to the surface and making it more relevant even from the abstract.
| null | null |
Major comments: 1-My main issue is with the way the results are presented.
| null | null |
medsci4030012_makarova
| 0 |
Therefore, the authors pointed out that validation and confirmation of the results in a large sample size will be needed in the future.
| null | null |
Recurrent aberrations of 98 CNA regions were also identified in cases only.
| null | null |
medsci4030012_makarova
| 0 |
It is not clear if there is one or two groups but just one percentage.
| null | null |
It is not clear which statistical method is used for the significant results.
| null | null |
medsci4030012_makarova
| 0 |
2- The only real statistical inference they show is on the pathway analysis yet no mention is made on the abstract.
| null | null |
It is not clear which statistical method is used for the significant results in Table 2.
| null | null |
medsci4030012_makarova
| 0 |
The authors need to give more details about how to use PCA in statistical methods.
| null | null |
The results are novel and provide insight into how multiple CNAs might contribute to cervical cancer development.
| null | null |
medsci4030012_makarova
| 0 |
The authors mentioned the results by using PCA but PCA was not found in methods.
| null | null |
Broad comments This is the first genome-wide copy number analysis of CNAs identified for cervical cancer in the U.S. Latino population.
| null | null |
medsci4030012_makarova
| 0 |
I think that these finding are indeed intriguing and deserve to be pursued in a larger study.
| null | null |
Recurrent aberrations of 98 CNA regions were also identified in cases only.
| null | null |
medsci4030012_makarova
| 0 |
Therefore, the authors pointed out that validation and confirmation of the results in a large sample size will be needed in the future.
| null | null |
Then again there must be estimates of deletion burden for different types of cancers from TCGA studies.
| null | null |
medsci4030012_makarova
| 0 |
The results are novel and provide insight into how multiple CNAs might contribute to cervical cancer development.
| null | null |
The authors claim that they observed statistical differences between case and reference groups yet they do not preform a statistical test, nor give any p-value.
| null | null |
medsci4030012_makarova
| 0 |
The authors claim that they observed statistical differences between case and reference groups yet they do not preform a statistical test, nor give any p-value.
| null | null |
The experimental design is adequate and the statistical methods are updated.
| null | null |
medsci4030012_makarova
| 0 |
The authors have acknowledged the limitation of this study, for example, the small sample size.
| null | null |
The authors claim that they observed statistical differences between case and reference groups yet they do not preform a statistical test, nor give any p-value.
| null | null |
medsci4030012_makarova
| 0 |
You can refer to it as methodological alternative, in the introduction, for the limited number of cases and lack of control group; issues that must be tackle in a larger study.
| null | null |
However if the ancestry is only self reported as latino, then I would write latino in the title and mention the issue of genetic variability between latinos in the discussion.
| null | null |
medsci4030012_makarova
| 0 |
However if the ancestry is only self reported as latino, then I would write latino in the title and mention the issue of genetic variability between latinos in the discussion.
| null | null |
The ancestry of HapMap is not latino so therefore any test between cases and references will be confounded by ancestry.
| null | null |
medsci4030012_makarova
| 0 |
They found that the burden of deletions in these patients is much higher than expected, as compared with CNV burden in HapMap populations.
| null | null |
A total of 32 CNA regions identified contained tumor suppressor genes and oncogenes.
| null | null |
medsci4030012_makarova
| 0 |
Tobari and colleagues studied the CNV burden in patients with cervical cancer from Mexican American ancestry.
| null | null |
They found statistically significant difference of CNA burden between case and reference groups in different sizes of CNAs that included deletions and amplifications, e.g., a statistically significant difference of >100 kb deletions were observed between the reference and pre-cancer and cancer groups.
| null | null |
medsci4030012_perova
| 0 |
If you find good estimates then perhaps a statistical tests with those as your control group would be more believable.
| null | null |
[Response] great suggestions, thank the reviewer.
| null | null |
medsci4030012_perova
| 0 |
However, I think that the manuscript needs some substantial revisions before it can be published.
| null | null |
Then again there must be estimates of deletion burden for different types of cancers from TCGA studies.
| null | null |
medsci4030012_perova
| 0 |
They observed that their sample is enriched in CNV variants in pathways relevant to the phenotype like endometrial cancer and estrogen signaling pathway.
| null | null |
I think that these finding are indeed intriguing and deserve to be pursued in a larger study.
| null | null |
medsci4030012_perova
| 0 |
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