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The authors need to define “pre-cancer” in materials.
| null | null |
Broad comments This is the first genome-wide copy number analysis of CNAs identified for cervical cancer in the U.S. Latino population.
| null | null |
medsci4030012_perova
| 0 |
It is not clear which statistical method is used for the significant results.
| null | null |
The authors need to make clear about “pre-, cancer (91.3%) groups”.
| null | null |
medsci4030012_perova
| 0 |
Tobari and colleagues studied the CNV burden in patients with cervical cancer from Mexican American ancestry.
| null | null |
Tobari and colleagues studied the CNV burden in patients with cervical cancer from Mexican American ancestry.
| null | null |
medsci4030012_perova
| 0 |
The authors need to make clear about “pre-, cancer (91.3%) groups”.
| null | null |
They found statistically significant difference of CNA burden between case and reference groups in different sizes of CNAs that included deletions and amplifications, e.g., a statistically significant difference of >100 kb deletions were observed between the reference and pre-cancer and cancer groups.
| null | null |
medsci4030012_perova
| 0 |
[Response] great suggestions, thank the reviewer.
| null | null |
The authors may need to delete the part in lines 238-242.
| null | null |
medsci4030012_perova
| 0 |
The authors need to define “pre-cancer” in materials.
| null | null |
In the title it refers to Mexican American but in the rest of the manuscript it is treated as a latino population.
| null | null |
medsci4030012_perova
| 0 |
They observed that their sample is enriched in CNV variants in pathways relevant to the phenotype like endometrial cancer and estrogen signaling pathway.
| null | null |
It is not clear if there is one or two groups but just one percentage.
| null | null |
medsci4030012_perova
| 0 |
It is not clear if there is one or two groups but just one percentage.
| null | null |
However if the ancestry is only self reported as latino, then I would write latino in the title and mention the issue of genetic variability between latinos in the discussion.
| null | null |
medsci4030012_perova
| 0 |
I think that these finding are indeed intriguing and deserve to be pursued in a larger study.
| null | null |
Note that there are differences in admixture in the latino population depending of their country of origin.
| null | null |
medsci4030012_perova
| 0 |
Minor comments: 1-I missed a definition of the sample's ancestry.
| null | null |
I think that these finding are indeed intriguing and deserve to be pursued in a larger study.
| null | null |
medsci4030012_perova
| 0 |
In the experimental section of the 13C NMR it should be 125 MHz instead of 126 MHz.
| null | null |
Author Response Reviewer 1The manuscript described ''The vibrational NH stretching transitions in secondary amines with intramolecular NH···O hydrogen bonds were investigated by experimental and theoretical methods, considering a large number of compounds and covering a wide range of stretching wavenumbers'' but the paper needs very significant improvement before acceptance for publication.
| null | null |
molecules26247651_makarova
| 0 |
Rather, the author could check B3PW91 (it often performs better than B3LYP) or any newer suitable functional.
| null | null |
Check the font of the reference numbers in the text and correct
| null | null |
molecules26247651_makarova
| 0 |
Scheme 1 must be redrawn using ACS document 1996 and all structures cleaned up.
| null | null |
In the experimental section of the 13C NMR it should be 125 MHz instead of 126 MHz.
| null | null |
molecules26247651_makarova
| 0 |
Author Response Reviewer 1: Comments and Suggestions for Authors1.
| null | null |
There are some questions about the manuscript as follows: 1.
| null | null |
molecules26247651_makarova
| 0 |
The cell values do not align please correct them.
| null | null |
Full characterization of all synthesized compounds is required in the experimental section.
| null | null |
molecules26247651_makarova
| 0 |
In the experimental section of the 13C NMR it should be 125 MHz instead of 126 MHz.
| null | null |
The explanation should be cleared.Anyway, I think the article has some educational significance and could be published after few major and minor points are taken into account: Major: 1) The authors should give the reason for the nonlinear v(NH) vs delta correlation as it was (according to Dudek) linear for OH-O.
| null | null |
molecules26247651_makarova
| 0 |
Author Response Reviewer 1The manuscript described ''The vibrational NH stretching transitions in secondary amines with intramolecular NH···O hydrogen bonds were investigated by experimental and theoretical methods, considering a large number of compounds and covering a wide range of stretching wavenumbers'' but the paper needs very significant improvement before acceptance for publication.
| null | null |
Author Response Reviewer 1: Comments and Suggestions for Authors1.
| null | null |
molecules26247651_makarova
| 0 |
Author Response Reviewer 1The manuscript described ''The vibrational NH stretching transitions in secondary amines with intramolecular NH···O hydrogen bonds were investigated by experimental and theoretical methods, considering a large number of compounds and covering a wide range of stretching wavenumbers'' but the paper needs very significant improvement before acceptance for publication.
| null | null |
Author Response Reviewer 1: Comments and Suggestions for Authors1.
| null | null |
molecules26247651_makarova
| 0 |
There are some questions about the manuscript as follows: 1.
| null | null |
Minor: 183: should be SD = 34.3 cm-1186: ""are reasonable"": Taking into account that (i) this fit is rather unphysical(ii) moving the points by say 50cm-1 one way or the other would also give rather good fit, this phrase is rather an empty cliche."
| null | null |
molecules26247651_makarova
| 0 |
There are some errors in spelling, syntax, punctuation, usage of capital letters, consistency in language style in the manuscript that must be improved.2.
| null | null |
Author Response Reviewer 1: Comments and Suggestions for Authors1.
| null | null |
molecules26247651_makarova
| 0 |
The manuscript described ''The vibrational NH stretching transitions in secondary amines with intramolecular NH···O hydrogen bonds were investigated by experimental and theoretical methods, considering a large number of compounds and covering a wide range of stretching wavenumbers'' but the paper needs very significant improvement before acceptance for publication.
| null | null |
In the experimental section of the 13C NMR it should be 125 MHz instead of 126 MHz.
| null | null |
molecules26247651_makarova
| 0 |
Check the font of the reference numbers in the text and correct
| null | null |
The rationale for undertaking the research is a bit puzzling.
| null | null |
molecules26247651_makarova
| 0 |
All the 1HNMR and 13CNMR must be attached as supplementary information.
| null | null |
There are some errors in spelling, syntax, punctuation, usage of capital letters, consistency in language style in the manuscript that must be improved.2.
| null | null |
molecules26247651_makarova
| 0 |
In the experimental section of the 13C NMR it should be 125 MHz instead of 126 MHz.
| null | null |
It would be added value if these NH···O hydrogen bonds were also investigated in the solid state using XRD analysis.
| null | null |
molecules26247651_makarova
| 0 |
There are some questions about the manuscript as follows: 1.
| null | null |
Scheme 1 must be redrawn using ACS document 1996 and all structures cleaned up.
| null | null |
molecules26247651_makarova
| 0 |
It would be added value if these NH···O hydrogen bonds were also investigated in the solid state using XRD analysis.
| null | null |
I am curious what prompted the Authors to deal with N-H...O bonding in place of the earlier O-H...O.
| null | null |
molecules26247651_perova
| 0 |
The rationale for undertaking the research is a bit puzzling.
| null | null |
I am curious what prompted the Authors to deal with N-H...O bonding in place of the earlier O-H...O.
| null | null |
molecules26247651_perova
| 0 |
As indicated by the Reviewer, the present study is an extension of our previous OH···O binding studies.
| null | null |
3. All the 1HNMR and 13CNMR must be attached as supplementary information.
| null | null |
molecules26247651_perova
| 0 |
8. Check the font of the reference numbers in the text and correct
| null | null |
6. Use 4 significant figures for the RNH values in table 2 7.
| null | null |
molecules26247651_perova
| 0 |
6. Use 4 significant figures for the RNH values in table 2 7.
| null | null |
There are some questions about the manuscript as follows:1.
| null | null |
molecules26247651_perova
| 0 |
Anyway, I think the article has some educational significance and could be published after few major and minor points are taken into account: Major:
| null | null |
Author Response Reviewer 1The manuscript described ''The vibrational NH stretching transitions in secondary amines with intramolecular NH···O hydrogen bonds were investigated by experimental and theoretical methods, considering a large number of compounds and covering a wide range of stretching wavenumbers'' but the paper needs very significant improvement before acceptance for publication.
| null | null |
molecules26247651_perova
| 0 |
In the experimental section of the 13C NMR it should be 125 MHz instead of 126 MHz.
| null | null |
Correct subscripts and superscripts in the experimental also check the spacings to be consistent.
| null | null |
molecules26247651_perova
| 0 |
We have for some time wished to investigate the corresponding NH···O systems.
| null | null |
We have added a remark on this aspect to the Introduction section.
| null | null |
molecules26247651_perova
| 0 |
Minor: 183: should be SD = 34.3 cm-1186: ""are reasonable"": Taking into account that (i) this fit is rather unphysical(ii) moving the points by say 50cm-1 one way or the other would also give rather good fit, this phrase is rather an empty cliche. Figure 5: Why is the y-axis reversed?"
| null | null |
Rather, the author could check B3PW91 (it often performs better than B3LYP) or any newer suitable functional.
| null | null |
molecules26247651_perova
| 0 |
In this article, the authors describe the spectral characteristics of NH in the hydrogen bridge NH...O.
| null | null |
Author Response Reviewer 1: Comments and Suggestions for Authors1.
| null | null |
molecules26247651_perova
| 0 |
We have added a remark on this aspect to the Introduction section.
| null | null |
As indicated by the Reviewer, the present study is an extension of our previous OH···O binding studies.
| null | null |
molecules26247651_perova
| 0 |
There are some questions about the manuscript as follows:
| null | null |
3. All the 1HNMR and 13CNMR must be attached as supplementary information.
| null | null |
molecules26247651_perova
| 0 |
3. All the 1HNMR and 13CNMR must be attached as supplementary information.
| null | null |
There are some questions about the manuscript as follows:1.
| null | null |
molecules26247651_perova
| 0 |
Author Response Reviewer 1The manuscript described ''The vibrational NH stretching transitions in secondary amines with intramolecular NH···O hydrogen bonds were investigated by experimental and theoretical methods, considering a large number of compounds and covering a wide range of stretching wavenumbers'' but the paper needs very significant improvement before acceptance for publication.
| null | null |
I am curious what prompted the Authors to deal with N-H...O bonding in place of the earlier O-H...O.
| null | null |
molecules26247651_perova
| 0 |
[48] Accelrys Software Inc., Discovery Studio Modeling Environment, Release 4.0, San Diego: Accelrys Software Inc., 2013.
| null | null |
[26] Berrade, L.; Aisa, B.; Ramirez, M. J.; Galiano, S.; Guccione, S.; Moltzau, L. R.; Levy, F. O.; Nicoletti, F.; Battaglia, G.; Molinaro, G.; Aldana, I.; Monge, A.; Perez-Silanes, S. Novel Benzo[b]thiophene Derivatives as New Potential Antidepressants with Rapid Onset of Action.
| null | null |
molecules27051656_makarova
| 0 |
Molecular Docking Study Molecular docking is a powerful tool to investigate and provide a proper understanding for ligand receptor interactions in order to facilitate the design of potential drugs [93-96].
| null | null |
It is well-known that tyrosinase of Bacillus Megaterium bacteria is an attractive target for the development of antimicrobials or antibiotic adjuvants for the treatment of hyperpigmentation because of its similarity (33.5%) to the human enzyme [97-100].
| null | null |
molecules27051656_makarova
| 0 |
The authors are suggested to use some decoy ligands and calculate the enrichment value in order to justify the docking protocol followed by ALA scan (Alanine scanning) based MD experiments.
| null | null |
13C NMR (100 MHz, DMSO-d6, ppm): 159.44 (C=O), 154.55 (Ar-C), 148.91 (Ar-C), 143.22 (-C=N-), 140.48 (Ar-C), 130.06 (Ar-C), 129.44 (Ar-C), 128.20 (Ar-C), 125.75 (Ar- C), 15.32 (-CH3).
| null | null |
molecules27051656_makarova
| 0 |
Antimicrobial activity using agar disc diffusion method In vitro sensitivities of two gram-positive and two gram-negative bacteria including two fungal strains against the synthesized compounds were evaluated by agar disc diffusion method.
| null | null |
; Nahum Alves, C. Analysis of Kojic Acid Derivatives as Competitive Inhibitors of Tyrosinase: A Molecular Modeling Approach.
| null | null |
molecules27051656_makarova
| 0 |
how would we know that −7.7 and −8.8 are good scores or not?
| null | null |
Moreover, ALA44A, LYS47A, ALA44B, LYS47B, PRO52A, ALA40B and ILE139B were actively involved in the non-covalent interaction (hydrophobic pi-alkyl).
| null | null |
molecules27051656_makarova
| 0 |
A, 2002, 106, 10613-10621. https://doi.org/10.1021/jp0211786 [69] Li, Y.; Zhang, Y.; Niu, H.; Wang, C.; Qin, C.; Bai, X.; Wang, W. Schiff bases containing triphenylamine and pyrrole units: synthesis and electrochromic, acidochromic properties.
| null | null |
The authors did not report any Tyrosinase enzyme inhibition assay, they are requested to justify Tyrosinase inhibition as the probable mechanism of action for these sets of ligands by providing suitable literature references.
| null | null |
molecules27051656_makarova
| 0 |
A., 2002, 106, 6871-6875. https://doi.org/10.1021/jp020715j [88] Scrocco, E.; Tomasi, J.
| null | null |
The manuscript is well-written and must be accepted in its present form for publication in Molecules.
| null | null |
molecules27051656_makarova
| 0 |
An octanuclear [Co(II)2–Co(III)2]2 interlocked grid example of an inorganic [2]catenane†.
| null | null |
- Methods should be written in brief before presenting the results.
| null | null |
molecules27051656_makarova
| 0 |
- This sentence “ ) — NHN=CH — CO — hydrazone moiety ( - containing hydrazide Polytopic ligands are important for new drug development” should be better connected to the next one to explain why they are important for new drug development?
| null | null |
It is well-known that tyrosinase of Bacillus Megaterium bacteria is an attractive target for the development of antimicrobials or antibiotic 3 adjuvants for the treatment of hyperpigmentation because of its similarity (33.5%) to the human enzyme 97-103.
| null | null |
molecules27051656_makarova
| 0 |
It is well-known that tyrosinase of Bacillus Megaterium bacteria is an attractive target for the development of antimicrobials or antibiotic adjuvants for the treatment of hyperpigmentation because of its similarity (33.5%) to the human enzyme [97-100].
| null | null |
PDB ID 4j6u is for tyrosinase from Bacillus megaterium, not the bacillus megatherium crystal structure.
| null | null |
molecules27051656_makarova
| 0 |
Understanding the Regioselectivity on Diels−Alder Reactions.
| null | null |
The conclusion should briefly give an insight into the obtained results and also the limitations.
| null | null |
molecules27051656_makarova
| 0 |
Why did the authors consider Tyrosinase from Bacillus megaterium N205A mutant pdb id 4j6u?
| null | null |
Two gram-positive Staphylococcus aureus (cars-2) and Bacillus Megaterium (BTCC-18), two gram-negative Escherichia coli (carsgn-2) and Salmonella Typhi (K-323130) bacteria, and two fungal strains Trichoderma harzianum (carsm-2) and Aspergillus niger (carsm-3) were used in this study.
| null | null |
molecules27051656_makarova
| 0 |
5 Response: We appreciate the recommendation, and corrected this information as shown below: 3.2.
| null | null |
The 3D crystal structure of tyrosinase from Bacillus Megaterium (PDB ID: 4j6u; resolution: 2.5Å, Chain A, B) was obtained in pdb format from online RCSB protein data bank (PDB) database.
| null | null |
molecules27051656_makarova
| 0 |
Each disc was loaded with 25 µL of sample solution in DMSO containing 300 µg of synthesized compounds.
| null | null |
1 Manuscript ID #: Molecules 1583723 Journal: Molecules A detailed point-by-point response to the reviewers' comments We would like to thank the reviewers for the comments and endorsements of our work.
| null | null |
molecules27051656_makarova
| 0 |
The energy calculations were done by genetic algorithms.
| null | null |
[31] Ermiş, E. Synthesis, spectroscopic characterization and DFT calculations of novel Schiff base containing thiophene ring.
| null | null |
molecules27051656_makarova
| 0 |
To investigate and compare the antimicrobial activity of the synthesized compounds, docking analysis of L1 and L2 against tyrosinase from Bacillus Megaterium were performed.
| null | null |
New palladium(II) complexes of 5-nitrothiophene-2-carboxaldehyde thiosemicarbazones.
| null | null |
molecules27051656_makarova
| 0 |
Spect., 2014, 118, 672-682. http://dx.doi.org/10.1016/j.saa.2013.08.054 [71] Maryam, K.; Safar Ali, B.; Azar, G. Novel Schiff Bases of Pyrrole: Synthesis, Experimental and Theoretical Characterizations, Fluorescent Properties and Molecular Docking.
| null | null |
[42] Becke, A. D. Density‐functional thermochemistry.
| null | null |
molecules27051656_makarova
| 0 |
To investigate the biological activities of the ligands, L1 and L2 were tested in vitro bioassays against some Gram-negative and Gram-positive bacteria and the fungus strain.
| null | null |
[20] Tikhomirov, A. S.; Litvinova, V. A.; Andreeva, D. V.; Tsvetkov, V. B.; Dezhenkova, L. G.; Volodina, Y. L.; Kaluzhny, D. N.; Treshalin, I. D.; Schols, D.; Ramonova, A.
| null | null |
molecules27051656_perova
| 0 |
Struct., 2020, 1203, 127285. https://doi.org/10.1016/j.molstruc.2019.127285 [73] Cuenú, F.; Londoño-Salazar, J.; Torres, J. E.; Abonia, R.; D'Vries, R. F. Synthesis, structural characterization and theoretical studies of a new Schiff base 4-(((3-(tert-Butyl)-(1-phenyl) pyrazol-5-yl) imino) methyl) phenol.
| null | null |
Response: We appreciate the recommendation and rewrite the abstract as follows, 2 Polytopic organic ligands with hydrazone moiety are in the forefront of new drug research among many others due to their unique and versatile functionality and ease of strategic ligand design.
| null | null |
molecules27051656_perova
| 0 |
To investigate and compare the antimicrobial activity of the synthesized compounds, docking analysis of L1 and L2 against tyrosinase from Bacillus Megaterium were performed.
| null | null |
Data Collect., 2020, 27, 100393. https://doi.org/10.1016/j.cdc.2020.100393 [60] Sundaram, M. S. S.; Karthick, S.; Sailaja, K.; Karkuzhali, R.; Gopu, G. Theoretical study on cyclophane amide molecular receptors and its complexation behavior with TCNQ.
| null | null |
molecules27051656_perova
| 0 |
Chem., 2016, 40, 5245-5254. https://doi.org/10.1039/C6NJ00321D [70] Tanak, H.; Ağar A.
| null | null |
https://doi.org/10.1016/j.heliyon.2020.e04106 [59] Karpagakalyaani, G.; Daisy Magdaline, J.; Chithambarathanu, T.; Aruldhas, D.; Ronaldo Anuf, A. Spectroscopic (FT-IR, FT-Raman, NBO) Investigation and Molecular Docking study of a Herbicide compound Bifenox.
| null | null |
molecules27051656_perova
| 0 |
The structure was verified, and an energy minimization was performed with the Swiss-Pdb Viewer software packages (version 4.1.0) [44], since the crystal structure contains a variety of issues related to improper bond order, side chains geometry, and missing hydrogen atoms.
| null | null |
DOI:10.33945/SAMI/AJCA.2020.4.14 [57] Balachandran, V.; Santhi, G.; Karpagam, V.; Lakshmi, A. Molecular structure, spectroscopic (FT-IR, FT-Raman), NBO and HOMO–LUMO analyses, computation of thermodynamic functions for various temperatures of 2, 6-dichloro-3-nitrobenzoic acid.
| null | null |
molecules27051656_perova
| 0 |
Synthesis, structural, DFT studies, docking and antibacterial activity of a xanthene-based hydrazone ligand.
| null | null |
The docked conformation of the respective protein conformer with lowest binding free energy and root mean-square deviation value (RMSD) 0.0 Å was analyzed using PyMOL Molecular Graphics System (version 1.7.4) and Accelrys Discovery Studio 4.1 [49].
| null | null |
molecules27051656_perova
| 0 |
The binding site residues predicted by CASTp for tyrosinase were used for grid generation.
| null | null |
The binding site residues predicted by CASTp for tyrosinase were used for grid generation.
| null | null |
molecules27051656_perova
| 0 |
PDB ID 4j6u is for tyrosinase from Bacillus megaterium, not the bacillus megatherium crystal structure.
| null | null |
Molecular negative and positive - Gram .’’ megaterium Bacillus ainst tyrosinase from molecular behavior of L1 and L2 ag Section 2.3.1.
| null | null |
molecules27051656_perova
| 0 |
The binding site residues predicted by CASTp for tyrosinase were used for grid generation.
| null | null |
explored "Synthesis of Novel Tritopic Hydrazone Ligands: Spectroscopy, Biological activity, DFT, and Molecular docking Studies".
| null | null |
molecules27051656_perova
| 0 |
Even if it is an unstructured abstract, it should respond to the following point one after the other.
| null | null |
Author Response Manuscript ID #: Molecules 1583723 Journal: Molecules A detailed point-by-point response to the reviewers' comments We would like to thank the reviewers for the comments and endorsements of our work.
| null | null |
molecules27051656_perova
| 0 |
To investigate the biological activities of the ligands, L1 and L2 were tested in vitro bioassays against some Gram-negative and Gram-positive bacteria and the fungus strain.
| null | null |
The data at least should be split into 2 more subheads, one for the ligand and receptor preparation and the second for the docking analysis.
| null | null |
molecules27051656_perova
| 0 |
Enzyme Research, 2015, 2015, 1-12. http://dx.doi.org/10.1155/2015/262364 [99] Cardoso, R.; Valente, R.; Souza da Costa, C.H.
| null | null |
Attached below is our detailed response to the comments on our manuscript.
| null | null |
molecules27051656_perova
| 0 |
The sample discs were put gently on pre-inoculated agar plates and aerobically incubated for 24 h at 37 °C for antibacterial and for 48 h at 26 °C for antifungal assay.
| null | null |
Synthetic Communications, 2020, 50(6), 831-839. https://doi.org/10.1080/00397911.2020.1720737 [94] Shweta; Khan, E.; Tandon, P.; Maurya, R.; Kumar, P. A theoretical study on molecular structure, chemical reactivity and molecular docking studies on dalbergin and methyldalbergin.
| null | null |
molecules27051656_perova
| 0 |
All both compounds are biologically active but their activity was moderate which did not support their efforts.
| null | null |
Cancers, 2019, 11, 737. https://doi.org/10.3390/cancers11060737 [96] Yuan, Y.; Jin, W.; Nazir, Y.; Fercher, C.; Thomas Blaskovich, M.A.
| null | null |
molecules27051656_perova
| 0 |
Dr. Md Abdul Majed Patwary Comilla University Author Response File: Author Response.pdf
| null | null |
In addition, Molecular docking was used to study the molecular revealed that outcomes The Bacillus megaterium.
| null | null |
molecules27051656_perova
| 0 |
; da S. Gonçalves Vianez, J.L., Jr.; Santana da Costa, K.; de Molfetta, F.A.
| null | null |
Divide the data into those 2 subheads and add more about the software used to perform the docking and the parameters used (Grid box, extensiveness …) Response: We appreciate the recommendation, and splitted the data into 2 more subheads as, 3.2.1.
| null | null |
molecules27051656_perova
| 0 |
This work presented the method for multiple metal ions detection using a carbon quantum dots (CQDs) based chemosensor array by functionalization with different amino acids.
| null | null |
So, I suggest to accept this paper to Molecule with only minor revision: Comments 1: In page 2, you write the heading “2.
| null | null |
molecules27123843_makarova
| 0 |
Reviewer's comments and authors' replies: [Reviewer comments in black; Author response in blue.]
| null | null |
So, I suggest to accept this paper to Molecule with only minor revision: Comments 1: In page 2, you write the heading “2.
| null | null |
molecules27123843_makarova
| 0 |
It is also impressive that all 11 metal ions were successfully identified by LDA with 100% classification rate.
| null | null |
Reviewer's comments and authors' replies: [Reviewer comments in black; Author response in blue.]
| null | null |
molecules27123843_makarova
| 0 |
Write "On TEM images " instead of "Transmission electrone microscopy can be observed..." Reply: Thanks for the valuable comment.
| null | null |
We truly appreciate your positive comments on our work, as well as for raising interesting points, which lead to the improvement of the manuscript.
| null | null |
molecules27123843_makarova
| 0 |
Although the method of preparation of these sensors is not new, the implementation to chemosensor array is well presented.
| null | null |
This work presented the method for multiple metal ions detection using a carbon quantum dots (CQDs) based chemosensor array by functionalization with different amino acids.
| null | null |
molecules27123843_makarova
| 0 |
Although the method of preparation of these sensors is not new, the implementation to chemosensor array is well presented.
| null | null |
We truly appreciate your positive comments on our work, as well as for raising interesting points, which lead to the improvement of the manuscript.
| null | null |
molecules27123843_perova
| 0 |
-------------------------------------------------------------------- Response to Reviewer 1 This work presented the method for multiple metal ions detection using a carbon quantum dots (CQDs) based chemosensor array by functionalization with different amino acids.
| null | null |
Although the method of preparation of these sensors is not new, the implementation to chemosensor array is well presented.
| null | null |
molecules27123843_perova
| 0 |
Reviewer's comments and authors' replies: [Reviewer comments in black; Author response in blue.]
| null | null |
Results”, but the content of that paragraph belong to the introduction part.
| null | null |
molecules27123843_perova
| 0 |
The manuscript is an interesting research about developing a chemosensor array for metals ions detection simultaneously.
| null | null |
A detailed supplementary material is very helpful and useful for readers.
| null | null |
molecules27123843_perova
| 0 |
The CQDs with and without metal ions were systematically characterized (TEM, IR, XRD, XPS, etc).
| null | null |
-------------------------------------------------------------------- Response to Reviewer 2 The manuscript is interesting research about developing a chemosensor array for metals ions detection simultaneously.
| null | null |
molecules27123843_perova
| 0 |
From authors: Victor F. Tarasenko and Dmitry A. Sorokin Institute of High Current Electronics E-mail: [email protected]
| null | null |
One would expect a comparison between discharges that happen in gas mixtures of similar composition.
| null | null |
nano12040652_makarova
| 0 |
Reply: The text of the article was finalized and the English was improved.
| null | null |
The topic is timely and the results provided are interesting.
| null | null |
nano12040652_makarova
| 0 |
The article may be of interest, but for researchers in the field of plasma physics and gas discharges.
| null | null |
A point that should be clarified is the choice of the gases used for the discharges.
| null | null |
nano12040652_makarova
| 0 |
This is known from numerous studies of simpler and more understandable plasma objects such as glow discharge and arc.
| null | null |
For instance: Lines 168, 169 "An increase in the track brightness is apparently determined by an increase in the particle charge and size due to the evaporation of metal from the surface."
| null | null |
nano12040652_makarova
| 0 |
Reply: This judgment was removed from the text of the manuscript.
| null | null |
Lines 173-175 «Based on the brightness of the track glow, the plasma concentration at the particle surface increases with distance from the cathode.» Again, it is not clear how the plasma density on the particle surface can affect the brightness of the track glow.
| null | null |
nano12040652_makarova
| 0 |
However, most of the results provided consist in photographs of the discharges: while these are clear and descriptive, they provide a qualitative information only.
| null | null |
2) The article is more descriptive in nature, there is no explanation of physical laws, but which are misleading readers.
| null | null |
nano12040652_makarova
| 0 |
Other gases, such as argon, were chosen to better demonstrate the discoloration of the discharge.
| null | null |
A point that should be clarified is the choice of the gases used for the discharges.
| null | null |
nano12040652_makarova
| 0 |
In spark or arc discharge, as well as in bright spots the electrodes are locally heated to a high temperature, which leads to the evaporation of the electrode material.
| null | null |
Reply: This judgment was removed from the text of the manuscript.
| null | null |
nano12040652_makarova
| 0 |
The choice of the electrode material should be clearly explained in the present paper.
| null | null |
A spectral analysis is given for one discharge only (discharge in air with a copper electrode): more quantitative results, such as a spectral analysis of the other discharges also, would be helpful for the comparison between the discharges produced in the lab and the ones observed in the atmosphere.
| null | null |
nano12040652_makarova
| 0 |
Reply: In our preliminary studies, as well as in the papers of other authors, it was found that during pulsed discharges of short duration, the electrode material determines the composition of the vapors that evaporate from the electrodes and diffuse into the gap, including due to shock waves and turbulence.
| null | null |
Reply: In our preliminary studies, as well as in the papers of other authors, it was found that during pulsed discharges of short duration, the electrode material determines the composition of the vapors that evaporate from the electrodes and diffuse into the gap, including due to shock waves and turbulence.
| null | null |
nano12040652_makarova
| 0 |
Similar studies and comparisons with known experimental data could be carried out on these objects.
| null | null |
In spark or arc discharge, as well as in bright spots the electrodes are locally heated to a high temperature, which leads to the evaporation of the electrode material.
| null | null |
nano12040652_makarova
| 0 |
We hope for a positive decision regarding the publication of this article in this journal.
| null | null |
So, when using electrodes made of aluminum, steel and copper, we observed the glow of red, blue and green colors, respectively.
| null | null |
nano12040652_perova
| 0 |
The topic is timely and the results provided are interesting.
| null | null |
Reply: In our preliminary studies, as well as in the papers of other authors, it was found that during pulsed discharges of short duration, the electrode material determines the composition of the vapors that evaporate from the electrodes and diffuse into the gap, including due to shock waves and turbulence.
| null | null |
nano12040652_perova
| 0 |
Lines 173-175 «Based on the brightness of the track glow, the plasma concentration at the particle surface increases with distance from the cathode.» Again, it is not clear how the plasma density on the particle surface can affect the brightness of the track glow.
| null | null |
Where does the evaporation of the metal take place?
| null | null |
nano12040652_perova
| 0 |
Please describe better your experimental system, such as ignition energy.
| null | null |
In this regard, I would recommend that the authors revise the article (taking into account their colossal authority in the scientific community and the possibility of conducting more thorough experimental research) and send the article to a more specialized journal.
| null | null |
nano12040652_perova
| 0 |
This is known from numerous studies of simpler and more understandable plasma objects such as glow discharge and arc.
| null | null |
We believe that an increase in the ra-diation intensity of the particle is due to its heating during deceleration on gas particles.
| null | null |
nano12040652_perova
| 0 |
High-temperature zones on the electrodes also supply micro- and nanoparticles into a discharge gap.
| null | null |
One can agree with the influence of the particle size on the track size, but how can an increase in the particle charge affect the track glow?
| null | null |
nano12040652_perova
| 0 |
For instance: Lines 168, 169 "An increase in the track brightness is apparently determined by an increase in the particle charge and size due to the evaporation of metal from the surface."
| null | null |
High-temperature zones on the electrodes also supply micro- and nanoparticles into a discharge gap.
| null | null |
nano12040652_perova
| 0 |
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