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In what century long before Dutch did most West Germanic dialects probably lose case inflection?
15th
40,530
What to do for Diabetes, Heart Disease, and Stroke ?
- If you have diabetes, you are at least twice as likely as other people to have heart disease or a stroke. - Controlling the ABCs of diabetesA1C (blood glucose), blood pressure, and cholesterol-can cut your risk of heart disease and stroke. - Choosing foods wisely, quitting smoking, and taking medications (if needed) can all help lower your risk of heart disease and stroke. - If you have any warning signs of a heart attack or a stroke, get medical care immediatelydon't delay. Early treatment of heart attack and stroke in a hospital emergency room can reduce damage to the heart and the brain.
89,842
What is (are) laryngo-onycho-cutaneous syndrome ?
Laryngo-onycho-cutaneous (LOC) syndrome is a disorder that leads to abnormalities of the voicebox (laryngo-), finger- and toenails (onycho-), and skin (cutaneous). Many of the condition's signs and symptoms are related to the abnormal growth of granulation tissue in different parts of the body. This red, bumpy tissue is normally produced during wound healing and is usually replaced by skin cells as healing continues. However, in people with LOC syndrome, this tissue grows even when there is no major injury. One of the first symptoms in infants with LOC syndrome is a hoarse cry due to ulcers or overgrowth of granulation tissue in the voicebox (the larynx). Excess granulation tissue can also block the airways, leading to life-threatening breathing problems; as a result many affected individuals do not survive past childhood. In LOC syndrome, granulation tissue also grows in the eyes, specifically the conjunctiva, which are the moist tissues that line the eyelids and the white part of the eyes. Affected individuals often have impairment or complete loss of vision due to the tissue overgrowth. Another common feature of LOC syndrome is missing patches of skin (cutaneous erosions). The erosions heal slowly and may become infected. People with LOC syndrome can also have malformed nails and small, abnormal teeth. The hard, white material that forms the protective outer layer of each tooth (enamel) is thin, which contributes to frequent cavities. LOC syndrome is typically considered a subtype of another skin condition called junctional epidermolysis bullosa, which is characterized by fragile skin that blisters easily. While individuals with junctional epidermolysis bullosa can have some of the features of LOC syndrome, they do not usually have overgrowth of granulation tissue in the conjunctiva.
96,787
What did Russell combine at the headquarters?
printing and corporate offices with a house of worship
85,369
Who was the first person to drive through The Queens-Midtown Tunnel?
President Franklin D. Roosevelt
4,506
What organization's definition is widely used?
The International Association for the Study of Pain
76,207
What is made with an alloy of 4% aluminium mixed with 96% zinc?
stamping dies
67,019
How tall is Quirauk Mountain?
2,145 ft
67,305
In his book, Feynman was shown playing what instrument?
drums
70,566
Why are specific seasons for bow hunting established?
limit competition with hunters using more effective weapons
87,147
When did the torch relay in Paris occur?
April 7
8,270
White clam pie is found in what district of New Haven?
Wooster Street in the Little Italy section
44,195
What causeway connects South Beach with Downtown?
MacArthur
57,068
What is the outlook for Post-Polio Syndrome ?
PPS is a very slowly progressing condition marked by long periods of stability. The severity of PPS depends on the degree of the residual weakness and disability an individual has after the original polio attack. People who had only minimal symptoms from the original attack and subsequently develop PPS will most likely experience only mild PPS symptoms. People originally hit hard by the polio virus, who were left with severe residual weakness, may develop a more severe case of PPS with a greater loss of muscle function, difficulty in swallowing, and more periods of fatigue.
115,687
What happens to infected plant cells?
end
30,310
Are there rail services to Germany
International InterCityExpress (ICE) services to Germany (and further) through Arnhem call at Utrecht Centraal
53,204
Who runs Guam's main health care facility?
The Government of Guam
69,268
What church did the King's funeral take place on the 15th?
Windsor Castle
50,714
When was the organ first used?
the coronation of King George VI
16,768
What causes Causes of Diabetes ?
Other types of diabetes have a variety of possible causes. Genetic Mutations Affecting Beta Cells, Insulin, and Insulin Action Some relatively uncommon forms of diabetes known as monogenic diabetes are caused by mutations, or changes, in a single gene. These mutations are usually inherited, but sometimes the gene mutation occurs spontaneously. Most of these gene mutations cause diabetes by reducing beta cells ability to produce insulin. The most common types of monogenic diabetes are neonatal diabetes mellitus (NDM) and MODY. NDM occurs in the first 6 months of life. MODY is usually found during adolescence or early adulthood but sometimes is not diagnosed until later in life. More information about NDM and MODY is provided in the NIDDK health topic, Monogenic Forms of Diabetes. Other rare genetic mutations can cause diabetes by damaging the quality of insulin the body produces or by causing abnormalities in insulin receptors. Other Genetic Diseases Diabetes occurs in people with Down syndrome, Klinefelter syndrome, and Turner syndrome at higher rates than the general population. Scientists are investigating whether genes that may predispose people to genetic syndromes also predispose them to diabetes. The genetic disorders cystic fibrosis and hemochromatosis are linked to diabetes. Cystic fibrosis produces abnormally thick mucus, which blocks the pancreas. The risk of diabetes increases with age in people with cystic fibrosis. Hemochromatosis causes the body to store too much iron. If the disorder is not treated, iron can build up in and damage the pancreas and other organs. Damage to or Removal of the Pancreas Pancreatitis, cancer, and trauma can all harm the pancreatic beta cells or impair insulin production, thus causing diabetes. If the damaged pancreas is removed, diabetes will occur due to the loss of the beta cells. Endocrine Diseases Endocrine diseases affect organs that produce hormones. Cushings syndrome and acromegaly are examples of hormonal disorders that can cause prediabetes and diabetes by inducing insulin resistance. Cushings syndrome is marked by excessive production of cortisolsometimes called the stress hormone. Acromegaly occurs when the body produces too much growth hormone. Glucagonoma, a rare tumor of the pancreas, can also cause diabetes. The tumor causes the body to produce too much glucagon. Hyperthyroidism, a disorder that occurs when the thyroid gland produces too much thyroid hormone, can also cause elevated blood glucose levels. Autoimmune Disorders Rare disorders characterized by antibodies that disrupt insulin action can lead to diabetes. This kind of diabetes is often associated with other autoimmune disorders such as lupus erythematosus. Another rare autoimmune disorder called stiff-man syndrome is associated with antibodies that attack the beta cells, similar to type 1 diabetes. Medications and Chemical Toxins Some medications, such as nicotinic acid and certain types of diuretics, anti-seizure drugs, psychiatric drugs, and drugs to treat human immunodeficiency virus (HIV), can impair beta cells or disrupt insulin action. Pentamidine, a drug prescribed to treat a type of pneumonia, can increase the risk of pancreatitis, beta cell damage, and diabetes. Also, glucocorticoidssteroid hormones that are chemically similar to naturally produced cortisolmay impair insulin action. Glucocorticoids are used to treat inflammatory illnesses such as rheumatoid arthritis, asthma, lupus, and ulcerative colitis. Many chemical toxins can damage or destroy beta cells in animals, but only a few have been linked to diabetes in humans. For example, dioxina contaminant of the herbicide Agent Orange, used during the Vietnam Warmay be linked to the development of type 2 diabetes. In 2000, based on a report from the Institute of Medicine, the U.S. Department of Veterans Affairs (VA) added diabetes to the list of conditions for which Vietnam veterans are eligible for disability compensation. Also, a chemical in a rat poison no longer in use has been shown to cause diabetes if ingested. Some studies suggest a high intake of nitrogen-containing chemicals such as nitrates and nitrites might increase the risk of diabetes. Arsenic has also been studied for possible links to diabetes. Lipodystrophy Lipodystrophy is a condition in which fat tissue is lost or redistributed in the body. The condition is associated with insulin resistance and type 2 diabetes.
119,690
At the end of the 19th century what was the literacy rate for the public in the Empire believed to be?
15%
67,791
The Islamic Prophet Muhammad carried out a siege against what tribe in February 624?
the Banu Qaynuqa tribe
19,489
Whose capital was Beijing before the Manchu's?
Ming
82,513
What was the significance of Damascus during this time period?
capital of the Arab Caliphate
83,563
What occurred to the level of the sea when the Devonian period was finished?
A global drop
86,453
Where do African children find their first jobs?
home
55,586
What position is the switch in when saturated?
on
74,533
Is cri-du-chat syndrome inherited ?
Most cases of cri-du-chat syndrome are not inherited. The deletion occurs most often as a random event during the formation of reproductive cells (eggs or sperm) or in early fetal development. Affected people typically have no history of the disorder in their family. About 10 percent of people with cri-du-chat syndrome inherit the chromosome abnormality from an unaffected parent. In these cases, the parent carries a chromosomal rearrangement called a balanced translocation, in which no genetic material is gained or lost. Balanced translocations usually do not cause any health problems; however, they can become unbalanced as they are passed to the next generation. Children who inherit an unbalanced translocation can have a chromosomal rearrangement with extra or missing genetic material. Individuals with cri-du-chat syndrome who inherit an unbalanced translocation are missing genetic material from the short arm of chromosome 5, which results in the intellectual disability and health problems characteristic of this disorder.
96,365
What event ended the age of the dinosaur by causing a 75% extinction?
K-T Extinction
29,174
What are the treatments for geleophysic dysplasia ?
These resources address the diagnosis or management of geleophysic dysplasia: - Gene Review: Gene Review: Geleophysic Dysplasia - Genetic Testing Registry: Geleophysic dysplasia 2 - MedlinePlus Encyclopedia: Short Stature These resources from MedlinePlus offer information about the diagnosis and management of various health conditions: - Diagnostic Tests - Drug Therapy - Surgery and Rehabilitation - Genetic Counseling - Palliative Care
105,160
Why was philosophy taught in Ottoman madaris?
confirm the doctrines of Islam
68,501
What are the genetic changes related to Meckel syndrome ?
Meckel syndrome can be caused by mutations in one of at least eight genes. The proteins produced from these genes are known or suspected to play roles in cell structures called cilia. Cilia are microscopic, finger-like projections that stick out from the surface of cells and are involved in signaling pathways that transmit information between cells. Cilia are important for the structure and function of many types of cells, including brain cells and certain cells in the kidneys and liver. Mutations in the genes associated with Meckel syndrome lead to problems with the structure and function of cilia. Defects in these cell structures probably disrupt important chemical signaling pathways during early development. Although researchers believe that defective cilia are responsible for most of the features of this disorder, it remains unclear how they lead to specific developmental abnormalities of the brain, kidneys, and other parts of the body. Mutations in the eight genes known to be associated with Meckel syndrome account for about 75 percent of all cases of the condition. In the remaining cases, the genetic cause is unknown. Mutations in several other genes have been identified in people with features similar to those of Meckel syndrome, although it is unclear whether these individuals actually have Meckel syndrome or a related disorder (often described as a "Meckel-like phenotype").
108,833
What other causes are there for inflammatory diarrhea?
tuberculosis, colon cancer, and enteritis.
68,331
Which record did the song break, which was the biggest leap to the top of the Billboard charts?
The Beatles
7,152
What feature does the PocketFami have?
color LCD
35,359
What is Jehovah Witnesses' view of divorce?
discouraged
85,467
What is another term for southern Europe
Mediterranean Europe
11,089
When did the Seattle Super Sonics win an NBA championship?
1978–79
36,005
What does psychological anthropology particularly focus on in a particular culture group?
humans' development and enculturation
5,395
What was the play time of a 45 rpm
eight minutes
57,451
What group of nuns are used all aspects of the Dominican Order for their work?
Dartford
58,309
The Times features what in the first half of its newspaper?
news
24,426
What is (are) Opsoclonus Myoclonus ?
Opsoclonus myoclonus is a rare neurological disorder characterized by an unsteady, trembling gait, myoclonus (brief, shock-like muscle spasms), and opsoclonus (irregular, rapid eye movements). Other symptoms may include difficulty speaking, poorly articulated speech, or an inability to speak. A decrease in muscle tone, lethargy, irritability, and malaise (a vague feeling of bodily discomfort) may also be present. Opsoclonus myoclonus may occur in association with tumors or viral infections. It is often seen in children with tumors.
115,545
What options do Parental controls provide?
allows parents to monitor and manage their children's activities on a device with activity reports and safety controls
80,150
What physical factor must be continuously monitored during temperature studies>
temperatures
34,241
What is the popular name for Northwestern's traditional Armadillo Day?
Dillo Day
39,557
What is the Portuguese word for the short-cycle degrees awarded prior to 1988?
bacharelatos
9,977
What religion is the Flying Fathers team?
Catholic
60,387
What was Johnny Rotten's real name?
John Lydon
69,940
Where is the Semetic Akkadian language found preserved after 2800 BC?
king lists
80,938
Who showed up on the editorial floor of the Independent?
James Murdoch and Rebekah Wade
48,272
What causes Townes-Brocks syndrome ?
What causes Townes-Brocks syndrome? Townes-Brocks syndrome is caused by mutations in the SALL1 gene. This gene is part of a group of genes called the SALL family. These genes provide instructions for making proteins that are involved in the formation of tissues and organs before birth. SALL proteins act as transcription factors, which means they attach (bind) to specific regions of DNA and help control the activity of particular genes. Some mutations in the SALL1 gene lead to the production of an abnormally short version of the SALL1 protein that malfunctions within the cell. Other mutations prevent one copy of the gene in each cell from making any protein. It is unclear how these genetic changes disrupt normal development and cause the symptoms associated with Townes-Brocks syndrome.
100,486
What company was the structure at Clover Field for?
Douglas Aircraft
75,875
With whom does minority leader consult and participate in news conference?
counterparts in the Senate—and with the president if their party controls the White House
85,210
Are albums ever reproduced?
Many popular new albums are given releases
57,718
What is produced when copper compounds are treated with organolithium reagents?
Gilman reagent
26,686
What was inspired by the fall of the Berlin wall?
a pro-democracy movement
62,739
What private estate did Victoria aquire with Albert in 1847?
Balmoral Castle
37,509
Besides the U.N. Headquarters, who hosts many U.N. agencies?
Swiss Confederation
51,068
Where did the Romans attempt to escape to after their loss against the Gauls?
Rome
77,880
What occurred in February of 2016?
The OBA government simultaneously introduced a bill to permit Civil Unions
52,811
What is indicated by the factor √2?
there is half a stop of headroom to deal with specular reflections that would appear brighter than a 100% reflecting white surface
43,259
Which family overthrew the Seljuk Turks?
the Zakarid
76,895
Are the bacteria in caseous necrotic material living or dead?
living
54,832
What are the genetic changes related to distal hereditary motor neuropathy, type V ?
Mutations in the BSCL2 and GARS genes cause distal hereditary motor neuropathy, type V. The BSCL2 gene provides instructions for making a protein called seipin, whose function is unknown. Mutations in the BSCL2 gene likely alter the structure of seipin, causing it to fold into an incorrect 3-dimensional shape. Research findings indicate that misfolded seipin proteins accumulate in the endoplasmic reticulum, which is a structure inside the cell that is involved in protein processing and transport. This accumulation likely damages and kills motor neurons (specialized nerve cells in the brain and spinal cord that control muscle movement), leading to muscle weakness in the hands and feet. The GARS gene provides instructions for making an enzyme called glycyl-tRNA synthetase, which is involved in the production (synthesis) of proteins. It is unclear how GARS gene mutations lead to distal hereditary motor neuropathy, type V. The mutations probably reduce the activity of glycyl-tRNA synthetase. A reduction in the activity of this enzyme may impair transmission of nerve impulses. As a result, nerve cells slowly lose the ability to communicate with muscles in the hands and feet. Mutations in other genes may also cause distal hereditary motor neuropathy, type V.
95,299
What type of clubs does Arsenal have?
domestic supporters' clubs
40,265
How many records of sunspots are there?
112
53,895
what research (or clinical trials) is being done for Binswanger's Disease ?
The National Institute of Neurological Disorders and Stroke (NINDS) conducts research related to BD in its laboratories at the National Institutes of Health (NIH), and also supports additional research through grants to major medical institutions across the country. Much of this research focuses on finding better ways to prevent, treat, and ultimately cure neurological disorders, such as BD.
88,788
What year was the first Go-Getters album released?
1999
5,964
What are the symptoms of Split hand split foot nystagmus ?
What are the signs and symptoms of Split hand split foot nystagmus? People with this condition are born with split hands and feet. Split hands and split foot refers to a developmental malformation consisting of missing digits (fingers and/or toes), a deep median cleft (cleft down the center of the hand or foot), and fusion of remaining digits. People with this syndrome also have rapid involuntary movements of the eyes, called nystagmus. Abnormalities of the teeth can occur rarely. The Human Phenotype Ontology provides the following list of signs and symptoms for Split hand split foot nystagmus. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms. Signs and Symptoms Approximate number of patients (when available) Nystagmus 90% Split foot 90% Split hand 90% Abnormality of the metacarpal bones 50% Strabismus 50% Visual impairment 50% Abnormality of retinal pigmentation 7.5% Cataract 7.5% Autosomal dominant inheritance - Congenital nystagmus - Monodactyly (hands) - Retinopathy - The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature. The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined. Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common.
110,081
Paul claims the Resurrection was needed for what reason?
based on the plan of God
56,839
Why did Greg Dyke of London Weekend Television meet with representatives of the biggest five English football clubs in 1990?
The meeting was to pave the way for a break away from The Football League.
77,553
What term can characterize the status of bodies like the War Claims Commission and the Interstate Commerce Commission?
quasi-judicial
10,772
Why do birds need to perceive ultraviolet light?
courtship
82,301
How many African migrants entered Israel by June 2012?
60,000
38,256
What is emitted as a result of the photoelectric effect?
photoelectrons
54,570
It is only considered political corruption if the act directly relates to what?
their official duties
18,022
Where was Britain's claim to West Africa recognized in 1885?
the Berlin Conference
52,922
What year was the PlayStation 3 released?
2006
62,194
When were MANPADs introduced?
the 1960s
32,285
What is mechanical potential energy?
elastic strain
67,395
Who was the artist of the first song used?
Suzanne Vega
25,445
What causes Hemorrhagic shock and encephalopathy syndrome ?
What causes hemorrhagic shock and encephalopathy syndrome? The cause of hemorrhagic shock and encephalopathy syndrome is unknown. Some researchers believe that this condition is caused by a complex combination of genetic and environmental factors. Researchers have proposed various factors that may contribute to the development of this condition, including infection, exposure to toxins in the environment, and overwrapping of infants with a fever. Hemorrhagic shock and encephalopathy syndrome has not been reported to be associated with a specific ethnic group or religious background.
114,254
What did architects often neglect in their pursuit of aesthetics?
technical aspects of building design
10,955
What are the symptoms of Thymic-Renal-Anal-Lung dysplasia ?
What are the signs and symptoms of Thymic-Renal-Anal-Lung dysplasia? The Human Phenotype Ontology provides the following list of signs and symptoms for Thymic-Renal-Anal-Lung dysplasia. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms. Signs and Symptoms Approximate number of patients (when available) Abnormal lung lobation 90% Abnormality of female internal genitalia 90% Abnormality of the fingernails 90% Abnormality of the nose 90% Abnormality of the parathyroid gland 90% Aplasia/Hypoplasia of the lungs 90% Aplasia/Hypoplasia of the thymus 90% Hypoplasia of the ear cartilage 90% Hypoplastic toenails 90% Intestinal malrotation 90% Intrauterine growth retardation 90% Low-set, posteriorly rotated ears 90% Malar flattening 90% Multicystic kidney dysplasia 90% Oligohydramnios 90% Urogenital fistula 90% Abnormality of metabolism/homeostasis - Abnormality of the endocrine system - Abnormality of the respiratory system - Anal atresia - Autosomal recessive inheritance - Renal agenesis - Ureteral agenesis - Ureteral dysgenesis - The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature. The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined. Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common.
114,360
Is Angelman syndrome inherited ?
How might Angelman syndrome be inherited? Most cases of Angelman syndrome are not inherited, particularly those caused by a deletion in the maternal chromosome 15 or by paternal uniparental disomy. These genetic changes occur as random events during the formation of reproductive cells (eggs and sperm) or in early embryonic development. In these instances, people typically have no history of the disorder in their family. Rarely, a genetic change responsible for Angelman syndrome can be inherited. For example, it is possible for a mutation in the UBE3A gene or in the nearby region of DNA that controls gene activation to be passed from one generation to the next.
101,075
What is the name of the US-based firm in a production-sharing agreement with Cyprus?
Noble Energy
71,278
What was Sega's competitor to the NES called in the US?
Genesis
80,787
What film depicts the Chicago Cubs defeating a baseball team from Miami in the 2015 World Series?
Back to the Future Part II
41,332
Who ordered that a hymn be composed that first mentioned the Somalis?
the Abyssinian Emperor
22,959
What is (are) Oculofaciocardiodental syndrome ?
Oculofaciocardiodental syndrome is a genetic syndrome that affects the eyes, heart, face, and teeth. Common signs and symptoms include abnormally small deep-set eyes, cataracts, long narrow face, a broad nasal tip that is divided by a cleft, heart defects, and teeth with very large roots. Other signs and symptoms include glaucoma, cleft palate, delayed loss of baby teeth, missing or abnormally small teeth, misaligned teeth, and defective tooth enamel. Eye symptoms may involve one or both eyes.Oculofaciocardiodental syndrome is caused by mutations in the BCOR gene and is inherited in an X-linked dominant fashion.
110,528
What was the second name NBCSN was known as?
Versus
54,760
Instead of turning to a spiritual or divine source practicers of humanism turn to what?
science
86,279
Who was the chair that oversaw the editing of the standard?
Professor Musmann
25,455
When was the Assumption dogmatically define by the Catholic Church?
1950
31,168
When is ein diutscher first used?
12th century
43,709
What plan was implemented in September 1941?
Action Lauterbacher
28,109
What transliteration system is most common today?
IAST
32,572
What is navigation based on?
a variety of senses
25,011
When were the plans to update USB 3.0 to 10 Gbit/s revealed?
January 2013
59,137