smrynrz20/medical_quad · Datasets at Hugging Face

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What year did American Idol being to air on television?	2002	7,572
Where does the Rhine originate?	a 30 square kilometre area in Switzerland	20,727
Who made the move to standardize recordings?	National Association of Broadcasters	57,636
What liberal arts type colleges are in Cork?	Cork School of Music and Crawford College of Art and Design	58,659
What do query languages support in abstract interpretation frameworks?	sound approximation techniques	76,487
The Playstation 3 originally struggled for market share for what reasons?	due to being too expensive and initially lacking quality titles	29,494
What turned into the goal of the student body?	winning the big game	48,911
How many people are affected by tetrasomy 18p ?	Tetrasomy 18p is a rare disorder. It is known to affect about 250 families worldwide.	108,027
Who is the most successful solo artist in the history of American singles chart?	Madonna	46,816
What was attacked by Russians on July 31?	Lithuanian border post in Medininkai	56,650
In addition to the New Haven Harbor, what additional natural element is a prominent geographic feature of the area, flanking the northeast and northwest boundaries?	basalt trap rock ridges	44,010
Who did Wycliffe believe should read the Bible?	the laity	23,644
Describe Gaddafi's humble upbringing.	was born in a tent near Qasr Abu Hadi, a rural area outside the town of Sirte in the deserts of western Libya	70,669
The Society of Friends goal was what?	liberating Greece	42,211
what research (or clinical trials) is being done for Dravet Syndrome ?	The NINDS conducts and supports a broad program of basic and clinical research on all types of epilepsy, including Dravet syndrome. Study of the genetic defects responsible for Dravet syndrome and related disorders is expected to lead to the development of effective drug therapies.	115,430
What instrument is a phonautograph similar to?	pen	13,716
What can be seen as of essential importance to a practiced of humanism?	human beings	86,275
When did Virginia adopt The Principle of Partus Sequitur Ventrem?	1662	24,243
What country did Nigeria beat to win a Summer Olympics gold medal?	Argentina	53,128
What did Whitehead believe in so profusely that it was difficult to write a biography on him?	right to privacy	8,815
What are a couple examples of non-Summer music festivals in Portugal?	Flowfest or Hip Hop Porto	5,891
Who has written the only biography of Harper Lee?	Charles Shields	4,735
What is (are) Acquired Cystic Kidney Disease ?	Acquired cystic kidney disease happens when a person's kidneys develop fluid-filled sacs, called cysts, over time. Acquired cystic kidney disease is not the same as polycystic kidney disease (PKD), another disease that causes the kidneys to develop multiple cysts. Acquired cystic kidney disease occurs in children and adults who have - chronic kidney disease (CKD)a condition that develops over many years and may lead to end-stage kidney disease, or ESRD. The kidneys of people with CKD gradually lose their ability to filter wastes, extra salt, and fluid from the blood properly. - end-stage kidney diseasetotal and permanent kidney failure that requires a kidney transplant or blood-filtering treatments called dialysis. The cysts are more likely to develop in people who are on kidney dialysis. The chance of developing acquired cystic kidney disease increases with the number of years a person is on dialysis. However, the cysts are caused by CKD or kidney failure, not dialysis treatments. More information is provided in the NIDDK health topics, kidney failureand dialysis.	119,908
On that date, which elements were assisted by Prussian artillery forces?	Bavarian and two Prussian corps	33,113
What is (are) Unverricht-Lundborg disease ?	Unverricht-Lundborg disease is a rare inherited form of epilepsy. Affected individuals usually begin showing signs and symptoms of the disorder between the ages of 6 and 15. Unverricht-Lundborg disease is classified as a type of progressive myoclonus epilepsy. People with this disorder experience episodes of involuntary muscle jerking or twitching (myoclonus) that increase in frequency and severity over time. Episodes of myoclonus may be brought on by physical exertion, stress, light, or other stimuli. Within 5 to 10 years, the myoclonic episodes may become severe enough to interfere with walking and other everyday activities. Affected individuals also usually have seizures involving loss of consciousness, muscle rigidity, and convulsions (tonic-clonic or grand mal seizures). Like the myoclonic episodes, these may increase in frequency over several years but may be controlled with treatment. After several years of progression, the frequency of seizures may stabilize or decrease. Eventually people with Unverricht-Lundborg disease may develop problems with balance and coordination (ataxia), involuntary rhythmic shaking that worsens during movement (intentional tremor), difficulty speaking (dysarthria), depression, and a slow, mild decline in intellectual functioning. People with Unverricht-Lundborg disease typically live into adulthood. Depending on the severity of the condition and a person's response to treatment, life expectancy may be normal.	105,776
What are the symptoms of Synostoses, tarsal, carpal, and digital ?	What are the signs and symptoms of Synostoses, tarsal, carpal, and digital? The Human Phenotype Ontology provides the following list of signs and symptoms for Synostoses, tarsal, carpal, and digital. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms. Signs and Symptoms Approximate number of patients (when available) Anonychia - Aplasia/Hypoplasia of the middle phalanges of the hand - Autosomal dominant inheritance - Carpal synostosis - Metacarpophalangeal synostosis - Radial head subluxation - Short metacarpal - Tarsal synostosis - Underdeveloped nasal alae - The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature. The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined. Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common.	113,763
Who does Minister-President choose to run state agencies?	a cabinet	41,436
Why is xenon gas not more widely used?	more expensive, so its use is limited to smaller lamps	40,956
What are two main aspects of identity development?	self-clarity and self-esteem	30,708
What rank is the Chief Secretary?	usually a BPS-22 Civil Servant	86,720
In what part of India did the Tamil dynasties rule?	southern India	61,003
What happened to office buildings in Shanghai?	evacuated	3,380
In what films did Spielberg address war?	Empire of the Sun, Saving Private Ryan, War Horse and Bridge of Spies	71,367
What percentage of the children in Hyderabad city had basic vaccinations in 2005?	61%	75,699
If the officers want to advance their careers even further, where is that available?	Army Correspondence Course Program	33,066
What does the British-Irish Council discuss?	issues of mutual importance	79,735
What are the symptoms of Bone dysplasia lethal Holmgren type ?	What are the signs and symptoms of Bone dysplasia lethal Holmgren type? The Human Phenotype Ontology provides the following list of signs and symptoms for Bone dysplasia lethal Holmgren type. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms. Signs and Symptoms Approximate number of patients (when available) Abnormality of the femur 90% Abnormality of the ribs 90% Micromelia 90% Narrow chest 90% Short stature 90% Skeletal dysplasia 90% Weight loss 90% Abnormal diaphysis morphology 50% Abnormality of epiphysis morphology 50% Abnormality of the elbow 50% Abnormality of the metaphyses 50% Abnormality of the thumb 50% Anteverted nares 50% Depressed nasal ridge 50% Frontal bossing 50% Hearing abnormality 50% High forehead 50% Joint dislocation 50% Joint hypermobility 50% Malar flattening 50% Muscular hypotonia 50% Short neck 50% Abnormality of the skin 7.5% Anemia 7.5% Atria septal defect 7.5% Diarrhea 7.5% Hepatomegaly 7.5% Hernia 7.5% Hypertrophic cardiomyopathy 7.5% Nausea and vomiting 7.5% Patent ductus arteriosus 7.5% Recurrent respiratory infections 7.5% Respiratory insufficiency 7.5% Talipes 7.5% Thickened nuchal skin fold 7.5% Autosomal recessive inheritance - Bell-shaped thorax - Short ribs - The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature. The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined. Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common.	109,522
How does the 2009 Human Development Report refer to countries that rank "very high"?	developed countries	11,056
He was accused of selling grain for what reason?	his own personal gain	35,731
Where did some of the US Air Force traditions come from?	Royal Air Force	82,003
What water sport is popular in the city?	Rowing	68,686
Although for some countries the dollar is not their official currency, how do they use the currency?	de facto currency	27,753
On what Richmond street did General Lee live for a while?	Franklin	78,831
What is 'a scrimmage' another term for?	exhibition game	60,351
What sea is North of the Sahara Desert?	Mediterranean Sea	60,003
What are the treatments for Peripheral Arterial Disease (P.A.D.) ?	Yes. In some people, lifestyle changes are not enough to control P.A.D. Surgery and other procedures may be needed. These may include bypass grafting surgery, angioplasty, a stent, or a procedure called atherectomy (ath-eh-REK-to-mee). - Your doctor may recommend bypass grafting surgery if blood flow in your limb is blocked or nearly blocked. In this type of surgery, a blood vessel from another part of the body or a man-made tube is used to make a graft. This graft bypasses (goes around) the blocked part of the artery, which allows blood to flow around the blockage. This surgery doesn't cure P.A.D., but it may increase blood flow to the affected limb. Your doctor may recommend bypass grafting surgery if blood flow in your limb is blocked or nearly blocked. In this type of surgery, a blood vessel from another part of the body or a man-made tube is used to make a graft. This graft bypasses (goes around) the blocked part of the artery, which allows blood to flow around the blockage. This surgery doesn't cure P.A.D., but it may increase blood flow to the affected limb. - Angioplasty is used to restore blood flow through a narrowed or blocked artery. During this procedure, a catheter (thin tube) with a balloon or other device on the end is inserted into a blocked artery. The balloon is inflated, which pushes the plaque outward against the wall of the artery. This widens the artery and restores blood flow. Angioplasty is used to restore blood flow through a narrowed or blocked artery. During this procedure, a catheter (thin tube) with a balloon or other device on the end is inserted into a blocked artery. The balloon is inflated, which pushes the plaque outward against the wall of the artery. This widens the artery and restores blood flow. - A stent (a small mesh tube) may be placed in the artery during angioplasty. A stent helps keep the artery open after the procedure is done. Some stents are coated with medicine to help prevent blockages in the artery. A stent (a small mesh tube) may be placed in the artery during angioplasty. A stent helps keep the artery open after the procedure is done. Some stents are coated with medicine to help prevent blockages in the artery. - A procedure called atherectomy (ath-eh-REK-to-mee) may be used to remove plaque buildup from an artery. During the procedure, a catheter (thin tube) is used to insert a small cutting device into the blocked artery. The device is used to shave or cut off the plaque. The bits of plaque are removed from the body through the catheter or washed away in the bloodstream (if theyre small enough). Doctors also can do atherectomy using a special laser that dissolves the blockage. A procedure called atherectomy (ath-eh-REK-to-mee) may be used to remove plaque buildup from an artery. During the procedure, a catheter (thin tube) is used to insert a small cutting device into the blocked artery. The device is used to shave or cut off the plaque. The bits of plaque are removed from the body through the catheter or washed away in the bloodstream (if theyre small enough). Doctors also can do atherectomy using a special laser that dissolves the blockage.	118,683
What are the genetic changes related to cyclic neutropenia ?	Mutations in the ELANE gene cause cyclic neutropenia. The ELANE gene provides instructions for making a protein called neutrophil elastase, which is found in neutrophils. When the body starts an immune response to fight an infection, neutrophils release neutrophil elastase. This protein then modifies the function of certain cells and proteins to help fight the infection. ELANE gene mutations that cause cyclic neutropenia lead to an abnormal neutrophil elastase protein that seems to retain some of its function. However, neutrophils that produce abnormal neutrophil elastase protein appear to have a shorter lifespan than normal neutrophils. The shorter neutrophil lifespan is thought to be responsible for the cyclic nature of this condition. When the affected neutrophils die early, there is a period in which there is a shortage of neutrophils because it takes time for the body to replenish its supply.	93,189
What are the genetic changes related to alveolar capillary dysplasia with misalignment of pulmonary veins ?	ACD/MPV can be caused by mutations in the FOXF1 gene. The protein produced from the FOXF1 gene is a transcription factor, which means that it attaches (binds) to specific regions of DNA and helps control the activity of many other genes. The FOXF1 protein is important in development of the lungs and their blood vessels. The FOXF1 protein is also involved in the development of the gastrointestinal tract. Mutations in the FOXF1 gene that cause ACD/MPV result in an inactive protein that cannot regulate development, leading to abnormal formation of the pulmonary blood vessels and gastrointestinal tract. ACD/MPV can also be caused by a deletion of genetic material on the long arm of chromosome 16 in a region known as 16q24.1. This region includes several genes, including the FOXF1 gene. Deletion of one copy of the FOXF1 gene in each cell reduces the production of the FOXF1 protein. A shortage of FOXF1 protein affects the development of pulmonary blood vessels and causes the main features of ACD/MPV. Researchers suggest that the loss of other genes in this region probably causes the additional abnormalities, such as heart defects, seen in some infants with this disorder. Like FOXF1, these genes also provide instructions for making transcription factors that regulate development of various body systems before birth. In about 60 percent of affected infants, the genetic cause of ACD/MPV is unknown.	97,739
Whad did Nasser's enemies call him?	dictator	61,661
What relationship did Western countries continue with Estonia?	diplomatic relations	63,771
What is (are) Frank Ter Haar syndrome ?	Frank-Ter Haar syndrome is a rare inherited condition characterized by multiple skeletal abnormalities, developmental delay, and characteristic facial features (unusually large cornea, flattened back of the head, wide fontanels, prominent forehead, widely spaced eyes, prominent eyes, full cheeks, and small chin). Less than 30 cases have been reported worldwide. Protruding ears, prominent coccyx bone (or tail bone), and congenital heart defects are also frequently present. This condition is caused by mutations in the SH3PXD2B gene and is thought to be inherited in an autosomal recessive fashion.	114,514
What are the symptoms of Dystonia 5, Dopa-responsive type ?	What are the signs and symptoms of Dystonia 5, Dopa-responsive type? The Human Phenotype Ontology provides the following list of signs and symptoms for Dystonia 5, Dopa-responsive type. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms. Signs and Symptoms Approximate number of patients (when available) Autosomal recessive inheritance 5% Autosomal dominant inheritance - Babinski sign - Childhood onset - Gait ataxia - Hyperreflexia - Parkinsonism - Parkinsonism with favorable response to dopaminergic medication - Pes cavus - Phenotypic variability - Postural tremor - Scoliosis - Talipes equinovarus - Torticollis - Transient hyperphenylalaninemia - Writer's cramp - The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature. The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined. Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common.	98,687
What are the genetic changes related to hemophilia ?	Changes in the F8 gene are responsible for hemophilia A, while mutations in the F9 gene cause hemophilia B. The F8 gene provides instructions for making a protein called coagulation factor VIII. A related protein, coagulation factor IX, is produced from the F9 gene. Coagulation factors are proteins that work together in the blood clotting process. After an injury, blood clots protect the body by sealing off damaged blood vessels and preventing excessive blood loss. Mutations in the F8 or F9 gene lead to the production of an abnormal version of coagulation factor VIII or coagulation factor IX, or reduce the amount of one of these proteins. The altered or missing protein cannot participate effectively in the blood clotting process. As a result, blood clots cannot form properly in response to injury. These problems with blood clotting lead to continuous bleeding that can be difficult to control. The mutations that cause severe hemophilia almost completely eliminate the activity of coagulation factor VIII or coagulation factor IX. The mutations responsible for mild and moderate hemophilia reduce but do not eliminate the activity of one of these proteins. Another form of the disorder, known as acquired hemophilia, is not caused by inherited gene mutations. This rare condition is characterized by abnormal bleeding into the skin, muscles, or other soft tissues, usually beginning in adulthood. Acquired hemophilia results when the body makes specialized proteins called autoantibodies that attack and disable coagulation factor VIII. The production of autoantibodies is sometimes associated with pregnancy, immune system disorders, cancer, or allergic reactions to certain drugs. In about half of cases, the cause of acquired hemophilia is unknown.	93,319
In what year did Elizabeth pass Victoria's length of rule?	2015	34,304
What book is considered a religious interpretation of the traditions and early national history of the Jews?	The Hebrew Bible	47,765
What are the genetic changes related to prekallikrein deficiency ?	Prekallikrein deficiency is caused by mutations in the KLKB1 gene, which provides instructions for making a protein called prekallikrein. This protein, when converted to an active form called plasma kallikrein in the blood, is involved in the early stages of blood clotting. Plasma kallikrein plays a role in a process called the intrinsic coagulation pathway (also called the contact activation pathway). This pathway turns on (activates) proteins that are needed later in the clotting process. Blood clots protect the body after an injury by sealing off damaged blood vessels and preventing further blood loss. The KLKB1 gene mutations that cause prekallikrein deficiency reduce or eliminate functional plasma kallikrein, which likely impairs the intrinsic coagulation pathway. Researchers suggest that this lack (deficiency) of functional plasma kallikrein protein does not generally cause any symptoms because another process called the extrinsic coagulation pathway (also known as the tissue factor pathway) can compensate for the impaired intrinsic coagulation pathway.	97,199
Which term is in reference to people from a Christian culture?	Nasrani	12,682
What are the genetic changes related to Nakajo-Nishimura syndrome ?	Nakajo-Nishimura syndrome is caused by mutations in the PSMB8 gene. This gene provides instructions for making one part (subunit) of specialized cell structures called immunoproteasomes, which are found primarily in immune system cells. Immunoproteasomes play an important role in regulating the immune system's response to foreign invaders, such as viruses and bacteria. One of the primary functions of immunoproteasomes is to help the immune system distinguish the body's own proteins from proteins made by foreign invaders, so the immune system can respond appropriately to infection. Mutations in the PSMB8 gene greatly reduce the amount of protein produced from the PSMB8 gene, which impairs the normal assembly of immunoproteasomes and causes the immune system to malfunction. For unknown reasons, the malfunctioning immune system triggers abnormal inflammation that can damage the body's own tissues and organs; as a result, Nakajo-Nishimura syndrome is classified as an autoinflammatory disorder. Abnormal inflammation likely underlies many of the signs and symptoms of Nakajo-Nishimura syndrome, including the nodular erythema, recurrent fevers, joint problems, and hepatosplenomegaly. It is less clear how mutations in the PSMB8 gene lead to muscle wasting and lipodystrophy. Studies suggest that the protein produced from the PSMB8 gene may play a separate role in the maturation of fat cells (adipocytes), and a shortage of this protein may interfere with the normal development and function of these cells.	106,313
Which state is known for its Mediterranean climate?	California	74,331
What group still uses race as a valid means to represent human biological diversity?	forensic anthropologists	65,289
Who only voted in the election of 1492?	senators	20,381
What causes Lucey-Driscoll syndrome ?	What causes Lucey-Driscoll syndrome? Lucey-Driscoll syndrome is caused by high levels of a bilirubin "conjugating enzyme inhibitor which is a substance that limits the ability of bilirubin to bind to an enzyme. When bilirubin does not bind efficiently, it builds up in the bloodstream. This inhibitor is thought to occur in the blood (serum) of pregnant women, and it likely blocks the enzyme activity necessary for the development of the fetal liver. Familial cases may result from the pregnant woman having a mutation in the uridine diphosphate-glucuronosyltransferase gene(UGT1A1).	100,651
High altitude needs in Germany were going to be handled by what?	a 75 mm gun from Krupp	32,262
What kind of eggs to all birds lay?	amniotic eggs	82,380
The extent of Victorias political influence became well known after the publishing of what?	her diary and letters	37,447
What is (are) Infectious Diseases ?	Infectious diseases kill more people worldwide than any other single cause. Infectious diseases are caused by germs. Germs are tiny living things that are found everywhere - in air, soil and water. You can get infected by touching, eating, drinking or breathing something that contains a germ. Germs can also spread through animal and insect bites, kissing and sexual contact. Vaccines, proper hand washing and medicines can help prevent infections. There are four main kinds of germs: - Bacteria - one-celled germs that multiply quickly and may release chemicals which can make you sick - Viruses - capsules that contain genetic material, and use your own cells to multiply - Fungi - primitive plants, like mushrooms or mildew - Protozoa - one-celled animals that use other living things for food and a place to live NIH: National Institute of Allergy and Infectious Diseases	93,006
How many people are affected by 3-methylcrotonyl-CoA carboxylase deficiency ?	This condition is detected in an estimated 1 in 36,000 newborns worldwide.	105,192
What fraction of Kathmandu's population died in an ancient earthquake?	third	87,365
Who was referenced as prime minister in a negative manner when the term was first used in its modern sense?	Sir Robert Walpole	9,781
What do Christians believe regarding Jesus' death?	instrumental in restoring humankind to relationship with God	56,826
When was the Triangle created?	1959	51,494
What health issue is compounded by the AIDS epidemic in Namibia?	malaria	81,630
By what means does Tuvalu plan to produce 95% of its energy?	Solar PV	81,152
What is Guam's climate characterized as?	tropical marine	69,198
Was there a specific reason many Nicaraguans fled to the U.S.?	the economic collapse of the country many more Nicaraguans migrated to the United States amongst other countries.	72,251
How many departments did the new store have, built in 1862?	nineteen	44,759
When did the AFL development league begin?	2000	16,130
What are the genetic changes related to spinocerebellar ataxia type 2 ?	Mutations in the ATXN2 gene cause SCA2. The ATXN2 gene provides instructions for making a protein called ataxin-2. This protein is found throughout the body, but its function is unknown. Ataxin-2 is found in the fluid inside cells (cytoplasm), where it appears to interact with a cell structure called the endoplasmic reticulum. The endoplasmic reticulum is involved in protein production, processing, and transport. Researchers believe that ataxin-2 may be involved in processing RNA, a chemical cousin of DNA. Ataxin-2 is also thought to play a role in the production of proteins from RNA (translation of DNA's genetic information). The ATXN2 gene mutations that cause SCA2 involve a DNA segment known as a CAG trinucleotide repeat. This segment is made up of a series of three DNA building blocks (cytosine, adenine, and guanine) that appear multiple times in a row. Normally, the CAG segment is repeated approximately 22 times within the gene, but it can be repeated up to 31 times without causing any health problems. Individuals with 32 or more CAG repeats in the ATXN2 gene develop SCA2. People with 32 or 33 repeats tend to first experience signs and symptoms of SCA2 in late adulthood, while people with more than 45 repeats usually have signs and symptoms by their teens. It is unclear how the abnormally long CAG segment affects the function of the ataxin-2 protein. The abnormal protein apparently leads to cell death, as people with SCA2 show loss of brain cells in different parts of the brain. Over time, the loss of brain cells causes the movement problems characteristic of SCA2.	107,588
What are the treatments for isolated lissencephaly sequence ?	These resources address the diagnosis or management of isolated lissencephaly sequence: - Gene Review: Gene Review: DCX-Related Disorders - Gene Review: Gene Review: LIS1-Associated Lissencephaly/Subcortical Band Heterotopia - Gene Review: Gene Review: Tubulinopathies Overview - Genetic Testing Registry: Lissencephaly 1 - Genetic Testing Registry: Lissencephaly 3 - Genetic Testing Registry: Lissencephaly, X-linked These resources from MedlinePlus offer information about the diagnosis and management of various health conditions: - Diagnostic Tests - Drug Therapy - Surgery and Rehabilitation - Genetic Counseling - Palliative Care	107,960
Who designed the Emerald necklace?	Frederick Law Olmsted	15,085
What word do physicists sometimes consider to be defined as particles exhibiting rest mass?	matter	16,613
What percentage of books borrowed were of a religious nature in England, Germany, and North America?	1	34,150
After the sync field, all packets are made of how many bit bytes?	8-bit bytes	59,308
How many people are affected by spastic paraplegia type 8 ?	The prevalence of all hereditary spastic paraplegias combined is estimated to be 1 to 18 in 100,000 people worldwide. Spastic paraplegia type 8 likely accounts for only a small percentage of all spastic paraplegia cases.	96,168
How many people are affected by Hemorrhoids ?	About 75 percent of people will have hemorrhoids at some point in their lives.1 Hemorrhoids are most common among adults ages 45 to 65.2 Hemorrhoids are also common in pregnant women.	89,926
What film festival will first air 'The BFG'?	Cannes Film Festival	71,559
What important figure was killed in the raid?	Swedish archbishop Johannes	63,695
What era is Pulcinella similar to?	Classical	18,545
What list did the United States add Libya to in 1979?	State Sponsors of Terrorism	70,956
In which year did the Synod of Constantinople confirm the veneration of images of Mary?	842	31,197
What causes Non-classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency ?	What causes non-classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency? Non-classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency (NCAH) is caused by changes (mutations) in the CYP21A2 gene. This gene provides instructions for making an enzyme called 21-hydroxylase, which is found in the adrenal glands. The adrenal glands are cone-shaped organs that sit on top of the kidneys and are responsible for releasing various types of hormones that the body needs to function. Mutations in CYP21A2 lead to deficient levels of 21-hydroxylase which cause low levels of hormones such as cortisol and/or aldosterone and an overproduction of androgens (male hormones such as testosterone). Cortisol is a hormone that affects energy levels, blood sugar levels, blood pressure, and the body's response to stress, illness, and injury. Aldosterone helps the body maintain the proper level of sodium (salt) and water and helps maintain blood pressure. Irregular levels of these hormones lead to the signs and symptoms of NCAH. The amount of functional 21-hydroxylase enzyme determines the severity of the disorder. People with NCAH have CYP21A2 mutations that result in the production of reduced amounts of the enzyme, but more enzyme than the classic form of congenital adrenal hyperplasia.	112,415
What did Humbert use to teach even weak members of the Dominican Order?	uncomplicated language	58,280
How many Fortune 1000 companies are based in Oklahoma?	six	60,718
What are the symptoms of Sonoda syndrome ?	What are the signs and symptoms of Sonoda syndrome? The Human Phenotype Ontology provides the following list of signs and symptoms for Sonoda syndrome. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms. Signs and Symptoms Approximate number of patients (when available) Abnormal dermatoglyphics 90% Abnormality of the oral cavity 90% Anteverted nares 90% Depressed nasal ridge 90% Generalized hyperpigmentation 90% Hypopigmentation of hair 90% Narrow mouth 90% Round face 90% Short nose 90% Short stature 90% Displacement of the external urethral meatus 50% Autosomal recessive inheritance - Depressed nasal bridge - High axial triradius - Intellectual disability - Ventricular septal defect - The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature. The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined. Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common.	112,813
What does OSUT stand for?	One Station Unit Training	33,019
Red was chosen as part of the Nazi flag to do what?	attract attention	72,767
In what state was Wanamakers established?	Pennsylvania	44,766
Why were three large portal used in the construction of the Roman Arch of Constantine?	to ease the problem of congestion	49,482
Do you have information about Sports Safety	Summary : Playing sports can be fun, but it can also be dangerous if you are not careful. You can help prevent injuries by - Getting a physical to make sure you are healthy before you start playing your sport - Wearing the right shoes, gear, and equipment - Drinking lots of water - Warming up and stretching If you have already hurt yourself playing a sport, make sure you recover completely before you start up again. If possible, protect the injured part of your body with padding, a brace, or special equipment. When you do start playing again, start slowly.	117,608
Is keratoderma with woolly hair inherited ?	Most cases of keratoderma with woolly hair have an autosomal recessive pattern of inheritance, which means both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they usually do not show signs and symptoms of the condition.	104,009

What year did American Idol being to air on television?

2002

7,572

Where does the Rhine originate?

a 30 square kilometre area in Switzerland

20,727

Who made the move to standardize recordings?

National Association of Broadcasters

57,636

What liberal arts type colleges are in Cork?

Cork School of Music and Crawford College of Art and Design

58,659

What do query languages support in abstract interpretation frameworks?

sound approximation techniques

76,487

The Playstation 3 originally struggled for market share for what reasons?

due to being too expensive and initially lacking quality titles

29,494

What turned into the goal of the student body?

winning the big game

48,911

How many people are affected by tetrasomy 18p ?

Tetrasomy 18p is a rare disorder. It is known to affect about 250 families worldwide.

108,027

Who is the most successful solo artist in the history of American singles chart?

Madonna

46,816

What was attacked by Russians on July 31?

Lithuanian border post in Medininkai

56,650

In addition to the New Haven Harbor, what additional natural element is a prominent geographic feature of the area, flanking the northeast and northwest boundaries?

basalt trap rock ridges

44,010

Who did Wycliffe believe should read the Bible?

the laity

23,644

Describe Gaddafi's humble upbringing.

was born in a tent near Qasr Abu Hadi, a rural area outside the town of Sirte in the deserts of western Libya

70,669

The Society of Friends goal was what?

liberating Greece

42,211

what research (or clinical trials) is being done for Dravet Syndrome ?

The NINDS conducts and supports a broad program of basic and clinical research on all types of epilepsy, including Dravet syndrome. Study of the genetic defects responsible for Dravet syndrome and related disorders is expected to lead to the development of effective drug therapies.

115,430

What instrument is a phonautograph similar to?

pen

13,716

What can be seen as of essential importance to a practiced of humanism?

human beings

86,275

When did Virginia adopt The Principle of Partus Sequitur Ventrem?

1662

24,243

What country did Nigeria beat to win a Summer Olympics gold medal?

Argentina

53,128

What did Whitehead believe in so profusely that it was difficult to write a biography on him?

right to privacy

8,815

What are a couple examples of non-Summer music festivals in Portugal?

Flowfest or Hip Hop Porto

5,891

Who has written the only biography of Harper Lee?

Charles Shields

4,735

What is (are) Acquired Cystic Kidney Disease ?

Acquired cystic kidney disease happens when a person's kidneys develop fluid-filled sacs, called cysts, over time. Acquired cystic kidney disease is not the same as polycystic kidney disease (PKD), another disease that causes the kidneys to develop multiple cysts. Acquired cystic kidney disease occurs in children and adults who have - chronic kidney disease (CKD)a condition that develops over many years and may lead to end-stage kidney disease, or ESRD. The kidneys of people with CKD gradually lose their ability to filter wastes, extra salt, and fluid from the blood properly. - end-stage kidney diseasetotal and permanent kidney failure that requires a kidney transplant or blood-filtering treatments called dialysis. The cysts are more likely to develop in people who are on kidney dialysis. The chance of developing acquired cystic kidney disease increases with the number of years a person is on dialysis. However, the cysts are caused by CKD or kidney failure, not dialysis treatments. More information is provided in the NIDDK health topics, kidney failureand dialysis.

119,908

On that date, which elements were assisted by Prussian artillery forces?

Bavarian and two Prussian corps

33,113

What is (are) Unverricht-Lundborg disease ?

Unverricht-Lundborg disease is a rare inherited form of epilepsy. Affected individuals usually begin showing signs and symptoms of the disorder between the ages of 6 and 15. Unverricht-Lundborg disease is classified as a type of progressive myoclonus epilepsy. People with this disorder experience episodes of involuntary muscle jerking or twitching (myoclonus) that increase in frequency and severity over time. Episodes of myoclonus may be brought on by physical exertion, stress, light, or other stimuli. Within 5 to 10 years, the myoclonic episodes may become severe enough to interfere with walking and other everyday activities. Affected individuals also usually have seizures involving loss of consciousness, muscle rigidity, and convulsions (tonic-clonic or grand mal seizures). Like the myoclonic episodes, these may increase in frequency over several years but may be controlled with treatment. After several years of progression, the frequency of seizures may stabilize or decrease. Eventually people with Unverricht-Lundborg disease may develop problems with balance and coordination (ataxia), involuntary rhythmic shaking that worsens during movement (intentional tremor), difficulty speaking (dysarthria), depression, and a slow, mild decline in intellectual functioning. People with Unverricht-Lundborg disease typically live into adulthood. Depending on the severity of the condition and a person's response to treatment, life expectancy may be normal.

105,776

What are the symptoms of Synostoses, tarsal, carpal, and digital ?

What are the signs and symptoms of Synostoses, tarsal, carpal, and digital? The Human Phenotype Ontology provides the following list of signs and symptoms for Synostoses, tarsal, carpal, and digital. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms. Signs and Symptoms Approximate number of patients (when available) Anonychia - Aplasia/Hypoplasia of the middle phalanges of the hand - Autosomal dominant inheritance - Carpal synostosis - Metacarpophalangeal synostosis - Radial head subluxation - Short metacarpal - Tarsal synostosis - Underdeveloped nasal alae - The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature. The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined. Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common.

113,763

Who does Minister-President choose to run state agencies?

a cabinet

41,436

Why is xenon gas not more widely used?

more expensive, so its use is limited to smaller lamps

40,956

What are two main aspects of identity development?

self-clarity and self-esteem

30,708

What rank is the Chief Secretary?

usually a BPS-22 Civil Servant

86,720

In what part of India did the Tamil dynasties rule?

southern India

61,003

What happened to office buildings in Shanghai?

evacuated

3,380

In what films did Spielberg address war?

Empire of the Sun, Saving Private Ryan, War Horse and Bridge of Spies

71,367

What percentage of the children in Hyderabad city had basic vaccinations in 2005?

61%

75,699

If the officers want to advance their careers even further, where is that available?

Army Correspondence Course Program

33,066

What does the British-Irish Council discuss?

issues of mutual importance

79,735

What are the symptoms of Bone dysplasia lethal Holmgren type ?

What are the signs and symptoms of Bone dysplasia lethal Holmgren type? The Human Phenotype Ontology provides the following list of signs and symptoms for Bone dysplasia lethal Holmgren type. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms. Signs and Symptoms Approximate number of patients (when available) Abnormality of the femur 90% Abnormality of the ribs 90% Micromelia 90% Narrow chest 90% Short stature 90% Skeletal dysplasia 90% Weight loss 90% Abnormal diaphysis morphology 50% Abnormality of epiphysis morphology 50% Abnormality of the elbow 50% Abnormality of the metaphyses 50% Abnormality of the thumb 50% Anteverted nares 50% Depressed nasal ridge 50% Frontal bossing 50% Hearing abnormality 50% High forehead 50% Joint dislocation 50% Joint hypermobility 50% Malar flattening 50% Muscular hypotonia 50% Short neck 50% Abnormality of the skin 7.5% Anemia 7.5% Atria septal defect 7.5% Diarrhea 7.5% Hepatomegaly 7.5% Hernia 7.5% Hypertrophic cardiomyopathy 7.5% Nausea and vomiting 7.5% Patent ductus arteriosus 7.5% Recurrent respiratory infections 7.5% Respiratory insufficiency 7.5% Talipes 7.5% Thickened nuchal skin fold 7.5% Autosomal recessive inheritance - Bell-shaped thorax - Short ribs - The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature. The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined. Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common.

109,522

How does the 2009 Human Development Report refer to countries that rank "very high"?

developed countries

11,056

He was accused of selling grain for what reason?

his own personal gain

35,731

Where did some of the US Air Force traditions come from?

Royal Air Force

82,003

What water sport is popular in the city?

Rowing

68,686

Although for some countries the dollar is not their official currency, how do they use the currency?

de facto currency

27,753

On what Richmond street did General Lee live for a while?

Franklin

78,831

What is 'a scrimmage' another term for?

exhibition game

60,351

What sea is North of the Sahara Desert?

Mediterranean Sea

60,003

What are the treatments for Peripheral Arterial Disease (P.A.D.) ?

Yes. In some people, lifestyle changes are not enough to control P.A.D. Surgery and other procedures may be needed. These may include bypass grafting surgery, angioplasty, a stent, or a procedure called atherectomy (ath-eh-REK-to-mee). - Your doctor may recommend bypass grafting surgery if blood flow in your limb is blocked or nearly blocked. In this type of surgery, a blood vessel from another part of the body or a man-made tube is used to make a graft. This graft bypasses (goes around) the blocked part of the artery, which allows blood to flow around the blockage. This surgery doesn't cure P.A.D., but it may increase blood flow to the affected limb. Your doctor may recommend bypass grafting surgery if blood flow in your limb is blocked or nearly blocked. In this type of surgery, a blood vessel from another part of the body or a man-made tube is used to make a graft. This graft bypasses (goes around) the blocked part of the artery, which allows blood to flow around the blockage. This surgery doesn't cure P.A.D., but it may increase blood flow to the affected limb. - Angioplasty is used to restore blood flow through a narrowed or blocked artery. During this procedure, a catheter (thin tube) with a balloon or other device on the end is inserted into a blocked artery. The balloon is inflated, which pushes the plaque outward against the wall of the artery. This widens the artery and restores blood flow. Angioplasty is used to restore blood flow through a narrowed or blocked artery. During this procedure, a catheter (thin tube) with a balloon or other device on the end is inserted into a blocked artery. The balloon is inflated, which pushes the plaque outward against the wall of the artery. This widens the artery and restores blood flow. - A stent (a small mesh tube) may be placed in the artery during angioplasty. A stent helps keep the artery open after the procedure is done. Some stents are coated with medicine to help prevent blockages in the artery. A stent (a small mesh tube) may be placed in the artery during angioplasty. A stent helps keep the artery open after the procedure is done. Some stents are coated with medicine to help prevent blockages in the artery. - A procedure called atherectomy (ath-eh-REK-to-mee) may be used to remove plaque buildup from an artery. During the procedure, a catheter (thin tube) is used to insert a small cutting device into the blocked artery. The device is used to shave or cut off the plaque. The bits of plaque are removed from the body through the catheter or washed away in the bloodstream (if theyre small enough). Doctors also can do atherectomy using a special laser that dissolves the blockage. A procedure called atherectomy (ath-eh-REK-to-mee) may be used to remove plaque buildup from an artery. During the procedure, a catheter (thin tube) is used to insert a small cutting device into the blocked artery. The device is used to shave or cut off the plaque. The bits of plaque are removed from the body through the catheter or washed away in the bloodstream (if theyre small enough). Doctors also can do atherectomy using a special laser that dissolves the blockage.

118,683

What are the genetic changes related to cyclic neutropenia ?

Mutations in the ELANE gene cause cyclic neutropenia. The ELANE gene provides instructions for making a protein called neutrophil elastase, which is found in neutrophils. When the body starts an immune response to fight an infection, neutrophils release neutrophil elastase. This protein then modifies the function of certain cells and proteins to help fight the infection. ELANE gene mutations that cause cyclic neutropenia lead to an abnormal neutrophil elastase protein that seems to retain some of its function. However, neutrophils that produce abnormal neutrophil elastase protein appear to have a shorter lifespan than normal neutrophils. The shorter neutrophil lifespan is thought to be responsible for the cyclic nature of this condition. When the affected neutrophils die early, there is a period in which there is a shortage of neutrophils because it takes time for the body to replenish its supply.

93,189

What are the genetic changes related to alveolar capillary dysplasia with misalignment of pulmonary veins ?

ACD/MPV can be caused by mutations in the FOXF1 gene. The protein produced from the FOXF1 gene is a transcription factor, which means that it attaches (binds) to specific regions of DNA and helps control the activity of many other genes. The FOXF1 protein is important in development of the lungs and their blood vessels. The FOXF1 protein is also involved in the development of the gastrointestinal tract. Mutations in the FOXF1 gene that cause ACD/MPV result in an inactive protein that cannot regulate development, leading to abnormal formation of the pulmonary blood vessels and gastrointestinal tract. ACD/MPV can also be caused by a deletion of genetic material on the long arm of chromosome 16 in a region known as 16q24.1. This region includes several genes, including the FOXF1 gene. Deletion of one copy of the FOXF1 gene in each cell reduces the production of the FOXF1 protein. A shortage of FOXF1 protein affects the development of pulmonary blood vessels and causes the main features of ACD/MPV. Researchers suggest that the loss of other genes in this region probably causes the additional abnormalities, such as heart defects, seen in some infants with this disorder. Like FOXF1, these genes also provide instructions for making transcription factors that regulate development of various body systems before birth. In about 60 percent of affected infants, the genetic cause of ACD/MPV is unknown.

97,739

Whad did Nasser's enemies call him?

dictator

61,661

What relationship did Western countries continue with Estonia?

diplomatic relations

63,771

What is (are) Frank Ter Haar syndrome ?

Frank-Ter Haar syndrome is a rare inherited condition characterized by multiple skeletal abnormalities, developmental delay, and characteristic facial features (unusually large cornea, flattened back of the head, wide fontanels, prominent forehead, widely spaced eyes, prominent eyes, full cheeks, and small chin). Less than 30 cases have been reported worldwide. Protruding ears, prominent coccyx bone (or tail bone), and congenital heart defects are also frequently present. This condition is caused by mutations in the SH3PXD2B gene and is thought to be inherited in an autosomal recessive fashion.

114,514

What are the symptoms of Dystonia 5, Dopa-responsive type ?

What are the signs and symptoms of Dystonia 5, Dopa-responsive type? The Human Phenotype Ontology provides the following list of signs and symptoms for Dystonia 5, Dopa-responsive type. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms. Signs and Symptoms Approximate number of patients (when available) Autosomal recessive inheritance 5% Autosomal dominant inheritance - Babinski sign - Childhood onset - Gait ataxia - Hyperreflexia - Parkinsonism - Parkinsonism with favorable response to dopaminergic medication - Pes cavus - Phenotypic variability - Postural tremor - Scoliosis - Talipes equinovarus - Torticollis - Transient hyperphenylalaninemia - Writer's cramp - The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature. The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined. Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common.

98,687

What are the genetic changes related to hemophilia ?

Changes in the F8 gene are responsible for hemophilia A, while mutations in the F9 gene cause hemophilia B. The F8 gene provides instructions for making a protein called coagulation factor VIII. A related protein, coagulation factor IX, is produced from the F9 gene. Coagulation factors are proteins that work together in the blood clotting process. After an injury, blood clots protect the body by sealing off damaged blood vessels and preventing excessive blood loss. Mutations in the F8 or F9 gene lead to the production of an abnormal version of coagulation factor VIII or coagulation factor IX, or reduce the amount of one of these proteins. The altered or missing protein cannot participate effectively in the blood clotting process. As a result, blood clots cannot form properly in response to injury. These problems with blood clotting lead to continuous bleeding that can be difficult to control. The mutations that cause severe hemophilia almost completely eliminate the activity of coagulation factor VIII or coagulation factor IX. The mutations responsible for mild and moderate hemophilia reduce but do not eliminate the activity of one of these proteins. Another form of the disorder, known as acquired hemophilia, is not caused by inherited gene mutations. This rare condition is characterized by abnormal bleeding into the skin, muscles, or other soft tissues, usually beginning in adulthood. Acquired hemophilia results when the body makes specialized proteins called autoantibodies that attack and disable coagulation factor VIII. The production of autoantibodies is sometimes associated with pregnancy, immune system disorders, cancer, or allergic reactions to certain drugs. In about half of cases, the cause of acquired hemophilia is unknown.

93,319

In what year did Elizabeth pass Victoria's length of rule?

2015

34,304

What book is considered a religious interpretation of the traditions and early national history of the Jews?

The Hebrew Bible

47,765

What are the genetic changes related to prekallikrein deficiency ?

Prekallikrein deficiency is caused by mutations in the KLKB1 gene, which provides instructions for making a protein called prekallikrein. This protein, when converted to an active form called plasma kallikrein in the blood, is involved in the early stages of blood clotting. Plasma kallikrein plays a role in a process called the intrinsic coagulation pathway (also called the contact activation pathway). This pathway turns on (activates) proteins that are needed later in the clotting process. Blood clots protect the body after an injury by sealing off damaged blood vessels and preventing further blood loss. The KLKB1 gene mutations that cause prekallikrein deficiency reduce or eliminate functional plasma kallikrein, which likely impairs the intrinsic coagulation pathway. Researchers suggest that this lack (deficiency) of functional plasma kallikrein protein does not generally cause any symptoms because another process called the extrinsic coagulation pathway (also known as the tissue factor pathway) can compensate for the impaired intrinsic coagulation pathway.

97,199

Which term is in reference to people from a Christian culture?

Nasrani

12,682

What are the genetic changes related to Nakajo-Nishimura syndrome ?

Nakajo-Nishimura syndrome is caused by mutations in the PSMB8 gene. This gene provides instructions for making one part (subunit) of specialized cell structures called immunoproteasomes, which are found primarily in immune system cells. Immunoproteasomes play an important role in regulating the immune system's response to foreign invaders, such as viruses and bacteria. One of the primary functions of immunoproteasomes is to help the immune system distinguish the body's own proteins from proteins made by foreign invaders, so the immune system can respond appropriately to infection. Mutations in the PSMB8 gene greatly reduce the amount of protein produced from the PSMB8 gene, which impairs the normal assembly of immunoproteasomes and causes the immune system to malfunction. For unknown reasons, the malfunctioning immune system triggers abnormal inflammation that can damage the body's own tissues and organs; as a result, Nakajo-Nishimura syndrome is classified as an autoinflammatory disorder. Abnormal inflammation likely underlies many of the signs and symptoms of Nakajo-Nishimura syndrome, including the nodular erythema, recurrent fevers, joint problems, and hepatosplenomegaly. It is less clear how mutations in the PSMB8 gene lead to muscle wasting and lipodystrophy. Studies suggest that the protein produced from the PSMB8 gene may play a separate role in the maturation of fat cells (adipocytes), and a shortage of this protein may interfere with the normal development and function of these cells.

106,313

Which state is known for its Mediterranean climate?

California

74,331

What group still uses race as a valid means to represent human biological diversity?

forensic anthropologists

65,289

Who only voted in the election of 1492?

senators

20,381

What causes Lucey-Driscoll syndrome ?

What causes Lucey-Driscoll syndrome? Lucey-Driscoll syndrome is caused by high levels of a bilirubin "conjugating enzyme inhibitor which is a substance that limits the ability of bilirubin to bind to an enzyme. When bilirubin does not bind efficiently, it builds up in the bloodstream. This inhibitor is thought to occur in the blood (serum) of pregnant women, and it likely blocks the enzyme activity necessary for the development of the fetal liver. Familial cases may result from the pregnant woman having a mutation in the uridine diphosphate-glucuronosyltransferase gene(UGT1A1).

100,651

High altitude needs in Germany were going to be handled by what?

a 75 mm gun from Krupp

32,262

What kind of eggs to all birds lay?

amniotic eggs

82,380

The extent of Victorias political influence became well known after the publishing of what?

her diary and letters

37,447

What is (are) Infectious Diseases ?

Infectious diseases kill more people worldwide than any other single cause. Infectious diseases are caused by germs. Germs are tiny living things that are found everywhere - in air, soil and water. You can get infected by touching, eating, drinking or breathing something that contains a germ. Germs can also spread through animal and insect bites, kissing and sexual contact. Vaccines, proper hand washing and medicines can help prevent infections. There are four main kinds of germs: - Bacteria - one-celled germs that multiply quickly and may release chemicals which can make you sick - Viruses - capsules that contain genetic material, and use your own cells to multiply - Fungi - primitive plants, like mushrooms or mildew - Protozoa - one-celled animals that use other living things for food and a place to live NIH: National Institute of Allergy and Infectious Diseases

93,006

How many people are affected by 3-methylcrotonyl-CoA carboxylase deficiency ?

This condition is detected in an estimated 1 in 36,000 newborns worldwide.

105,192

What fraction of Kathmandu's population died in an ancient earthquake?

third

87,365

Who was referenced as prime minister in a negative manner when the term was first used in its modern sense?

Sir Robert Walpole

9,781

What do Christians believe regarding Jesus' death?

instrumental in restoring humankind to relationship with God

56,826

When was the Triangle created?

1959

51,494

What health issue is compounded by the AIDS epidemic in Namibia?

malaria

81,630

By what means does Tuvalu plan to produce 95% of its energy?

Solar PV

81,152

What is Guam's climate characterized as?

tropical marine

69,198

Was there a specific reason many Nicaraguans fled to the U.S.?

the economic collapse of the country many more Nicaraguans migrated to the United States amongst other countries.

72,251

How many departments did the new store have, built in 1862?

nineteen

44,759

When did the AFL development league begin?

2000

16,130

What are the genetic changes related to spinocerebellar ataxia type 2 ?

Mutations in the ATXN2 gene cause SCA2. The ATXN2 gene provides instructions for making a protein called ataxin-2. This protein is found throughout the body, but its function is unknown. Ataxin-2 is found in the fluid inside cells (cytoplasm), where it appears to interact with a cell structure called the endoplasmic reticulum. The endoplasmic reticulum is involved in protein production, processing, and transport. Researchers believe that ataxin-2 may be involved in processing RNA, a chemical cousin of DNA. Ataxin-2 is also thought to play a role in the production of proteins from RNA (translation of DNA's genetic information). The ATXN2 gene mutations that cause SCA2 involve a DNA segment known as a CAG trinucleotide repeat. This segment is made up of a series of three DNA building blocks (cytosine, adenine, and guanine) that appear multiple times in a row. Normally, the CAG segment is repeated approximately 22 times within the gene, but it can be repeated up to 31 times without causing any health problems. Individuals with 32 or more CAG repeats in the ATXN2 gene develop SCA2. People with 32 or 33 repeats tend to first experience signs and symptoms of SCA2 in late adulthood, while people with more than 45 repeats usually have signs and symptoms by their teens. It is unclear how the abnormally long CAG segment affects the function of the ataxin-2 protein. The abnormal protein apparently leads to cell death, as people with SCA2 show loss of brain cells in different parts of the brain. Over time, the loss of brain cells causes the movement problems characteristic of SCA2.

107,588

What are the treatments for isolated lissencephaly sequence ?

These resources address the diagnosis or management of isolated lissencephaly sequence: - Gene Review: Gene Review: DCX-Related Disorders - Gene Review: Gene Review: LIS1-Associated Lissencephaly/Subcortical Band Heterotopia - Gene Review: Gene Review: Tubulinopathies Overview - Genetic Testing Registry: Lissencephaly 1 - Genetic Testing Registry: Lissencephaly 3 - Genetic Testing Registry: Lissencephaly, X-linked These resources from MedlinePlus offer information about the diagnosis and management of various health conditions: - Diagnostic Tests - Drug Therapy - Surgery and Rehabilitation - Genetic Counseling - Palliative Care

107,960

Who designed the Emerald necklace?

Frederick Law Olmsted

15,085

What word do physicists sometimes consider to be defined as particles exhibiting rest mass?

matter

16,613

What percentage of books borrowed were of a religious nature in England, Germany, and North America?

1

34,150

After the sync field, all packets are made of how many bit bytes?

8-bit bytes

59,308

How many people are affected by spastic paraplegia type 8 ?

The prevalence of all hereditary spastic paraplegias combined is estimated to be 1 to 18 in 100,000 people worldwide. Spastic paraplegia type 8 likely accounts for only a small percentage of all spastic paraplegia cases.

96,168

How many people are affected by Hemorrhoids ?

About 75 percent of people will have hemorrhoids at some point in their lives.1 Hemorrhoids are most common among adults ages 45 to 65.2 Hemorrhoids are also common in pregnant women.

89,926

What film festival will first air 'The BFG'?

Cannes Film Festival

71,559

What important figure was killed in the raid?

Swedish archbishop Johannes

63,695

What era is Pulcinella similar to?

Classical

18,545

What list did the United States add Libya to in 1979?

State Sponsors of Terrorism

70,956

In which year did the Synod of Constantinople confirm the veneration of images of Mary?

842

31,197

What causes Non-classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency ?

What causes non-classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency? Non-classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency (NCAH) is caused by changes (mutations) in the CYP21A2 gene. This gene provides instructions for making an enzyme called 21-hydroxylase, which is found in the adrenal glands. The adrenal glands are cone-shaped organs that sit on top of the kidneys and are responsible for releasing various types of hormones that the body needs to function. Mutations in CYP21A2 lead to deficient levels of 21-hydroxylase which cause low levels of hormones such as cortisol and/or aldosterone and an overproduction of androgens (male hormones such as testosterone). Cortisol is a hormone that affects energy levels, blood sugar levels, blood pressure, and the body's response to stress, illness, and injury. Aldosterone helps the body maintain the proper level of sodium (salt) and water and helps maintain blood pressure. Irregular levels of these hormones lead to the signs and symptoms of NCAH. The amount of functional 21-hydroxylase enzyme determines the severity of the disorder. People with NCAH have CYP21A2 mutations that result in the production of reduced amounts of the enzyme, but more enzyme than the classic form of congenital adrenal hyperplasia.

112,415

What did Humbert use to teach even weak members of the Dominican Order?

uncomplicated language

58,280

How many Fortune 1000 companies are based in Oklahoma?

six

60,718

What are the symptoms of Sonoda syndrome ?

What are the signs and symptoms of Sonoda syndrome? The Human Phenotype Ontology provides the following list of signs and symptoms for Sonoda syndrome. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms. Signs and Symptoms Approximate number of patients (when available) Abnormal dermatoglyphics 90% Abnormality of the oral cavity 90% Anteverted nares 90% Depressed nasal ridge 90% Generalized hyperpigmentation 90% Hypopigmentation of hair 90% Narrow mouth 90% Round face 90% Short nose 90% Short stature 90% Displacement of the external urethral meatus 50% Autosomal recessive inheritance - Depressed nasal bridge - High axial triradius - Intellectual disability - Ventricular septal defect - The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature. The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined. Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common.

112,813

What does OSUT stand for?

One Station Unit Training

33,019

Red was chosen as part of the Nazi flag to do what?

attract attention

72,767

In what state was Wanamakers established?

Pennsylvania

44,766

Why were three large portal used in the construction of the Roman Arch of Constantine?

to ease the problem of congestion

49,482

Do you have information about Sports Safety

Summary : Playing sports can be fun, but it can also be dangerous if you are not careful. You can help prevent injuries by - Getting a physical to make sure you are healthy before you start playing your sport - Wearing the right shoes, gear, and equipment - Drinking lots of water - Warming up and stretching If you have already hurt yourself playing a sport, make sure you recover completely before you start up again. If possible, protect the injured part of your body with padding, a brace, or special equipment. When you do start playing again, start slowly.

117,608

Is keratoderma with woolly hair inherited ?

Most cases of keratoderma with woolly hair have an autosomal recessive pattern of inheritance, which means both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they usually do not show signs and symptoms of the condition.

104,009