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{
"caption": "Reflecting the measurements performed in maxilla and mandibuler condyles. a) Measurement of the length of the maxilla; b) Measurement of the mediolateral width of the mandibuler condyles.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271343-4-medoral-27-e357-g002.jpg"
} | 009000 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Volumetric measurements of nasal cavity and mandibuler body (including condyles). Measurements were carried automatically on SimPlant computer program after marking the region of interest manually.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271343-5-medoral-27-e357-g004.jpg"
} | 009001 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Orthodontic angle measurements. a) Measurement of the angle SNA (Sella-Nasion-A point) which indicates the position of the maxilla according to the skull base; b) Measurement of the angle SNB (Sella-Nasion-B point) which indicates the position of the mandible according to the skull base; c) Measurement of the angle ANB (A point-Nasion- B point) which indicates the position of the maxilla according to the mandible.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271343-6-medoral-27-e357-g003.jpg"
} | 009002 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Retrograde filling after apicoectomy in 8 of the cases included in the study. Left: clinical intraoral view. Right: endoscopic view.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271345-1-medoral-27-e383-g001.jpg"
} | 009003 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Cone-beam computed tomography view (left: preoperative; right: postoperative) of four of the cases included in the study, showing the four healing subgroups according to the modified PENN 3D criteria: A) complete healing, B) limited healing, C) uncertain healing, D) unsatisfactory healing.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271345-5-medoral-27-e383-g003.jpg"
} | 009004 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Oral epithelial dysplasias according to the WHO and binary grading systems. (a) Without dysplasia, (b) mild epithelial dysplasia, (c) moderate epithelial dysplasia, (d) severe epithelial dysplasia; (a and b) low risk of malignancy, (c and d) high risk of malignancy (HE; bar =100 μm).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271346-2-medoral-27-e310-g002.jpg"
} | 009005 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Solid ameloblastoma mimicking apical periodontitis. Well-defined unilocular radiolucency in the anterior mandible extending from the left lateral incisor to the right first premolar, causing displacement of lower incisors and right canine.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271348-1-medoral-27-e397-g001.jpg"
} | 009006 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Solid ameloblastoma mimicking apical periodontitis. Well-defined unilocular radiolucency in the anterior mandible extending from the left lateral incisor to the right second premolar, causing teeth displacement and root resorption (Courtesy: Drs. Roberto Bastos and Henrique Martins da Silveira - Oral and Maxillofacial Surgery, Hospital Pedro Ernesto, Rio de Janeiro State University, Rio de Janeiro, Brazil).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271348-3-medoral-27-e397-g003.jpg"
} | 009007 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Immunoreactivity photomicrographs at 400x magnification; Bax (A-B); Bcl-2 (C-D); Cx43 membrane (E-F); E-cadherin (G-H); Ki67 (I-J). The number of positive cells from 3 randomly selected 10-3 mm2 fields was identified, obtaining a percentage of cells with: ≤5% (negative); 6 to 25% (low); 26 to 49% (middle); ≥50% (high). Black arrows indicate positive immunostaining.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271350-2-medoral-27-e366-g002.jpg"
} | 009008 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Hematoxylin and eosin stained 5 µm sections of oral squamous cell carcinoma. Tumor cells were present at all borders of the image field. (A-B) TSR ≤ 50%, stroma-poor. (C-D) Selection of the area with the highest proportion of stroma.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271351-5-medoral-27-e301-g001.jpg"
} | 009009 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Basilar predominant interstitial/reticular pulmonary opacities, patchy ground-glass opacities suggesting NSIP.NSIP: Nonspecific interstitial pneumonia",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271357-0-cureus-0014-00000026159-i03.jpg"
} | 009010 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Extensive peripheral interstitial disease with end-stage bibasilar airspace consolidation.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271357-1-cureus-0014-00000026159-i02.jpg"
} | 009011 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Diffuse parenchymal opacity in the lower lung fields with ground-glass opacities.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271357-2-cureus-0014-00000026159-i01.jpg"
} | 009012 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "TEE showing 7-mm presumed fibroelastoma present on the aortic valve (yellow arrow)TEE: transesophageal echocardiogram",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271363-0-cureus-0014-00000026722-i02.jpg"
} | 009013 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "MRI Axial T2 FLAIR demonstrating right insular CVA (yellow arrow) MRI: magnetic resonance imaging; FLAIR: fluid-attenuated inversion recovery; CVA: cerebrovascular accident",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271363-1-cureus-0014-00000026722-i01.jpg"
} | 009014 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Effects of intrauterine growth restriction on the cell cycle, proliferation index and expression of proliferating cell nuclear antigen in ovine fetal thymuses during late pregnancy. Panel A shows the cell cycle in the fetal thymuses. Frames B shows the proliferation index in the fetal thymuses. Frames C shows the total number of PCNA positive cell in the fetal thymuses. Frames D from sections of fetal thymic tissues shows staining for proliferating cell nuclear antigen; Magnification, ×400 (the arrow indicates a red PCNA). Bars, 50 μm. CG, control group, ad libitum, 0.67 MJ ME/BW0.75/d; RG2, restricted group2, 0.33 MJ ME/BW0.75/d; RG1, restricted group1, 0.18 MJ ME/BW0.75/d; G0/G1, gap 0/1 phase; S, synthesis of DNA phase; G2/M, gap 2 phase/cell division phase. PCNA, proliferating cell nuclear antigen; ME, metabolizable energy; BW, body weight. Duncan’s test was used to identify significant differences between mean values. a,b Means without common letters are different at p<0.05.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271382-2-ab-21-0414f1.jpg"
} | 009015 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Effect of maternal undernutrition during late pregnancy on expression of PPARγ and C/EBPα in fetal perirenal adipose tissue. (a) relative mRNA level of PPARγ and C/EBPα. (b) Western blot of PPARγ. (c) Western blot of C/EBPα. PPARγ and C/EBPα protein expression of all samples were expressed as fold changes, calculated relative to the CG group. (d) quantitative data in immunohistochemical analysis of PPARγ. (e) quantitative data in immunohistochemical analysis of C/EBPα. (f) immunohistochemical staining of PPARγ and C/EBPα expression in fetal perirenal BAT (bar = 50 μm), the arrows indicate the location of the nucleus expressing PPARγ and CEBPα, to respectively. PPARγ, peroxisome proliferator-activated receptor-γ; C/EBPα, CCAAT/enhancer-binding protein-α; BAT, brown adipose tissue. a,b Bars with a different superscript differ (p<0.05).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271387-2-ab-21-0199f4.jpg"
} | 009016 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Effect of maternal undernutrition during late pregnancy on the histology and UCP1 expression of perinatal adipose tissue in ovine fetuses. (a) H&E staining of sections of fetal perinatal adipose tissues (A–C the large and small arrows indicate brown adipose tissue and white adipose tissue, respectively [bar = 50 μm]) and immunohistochemical staining of UCP1 expression in fetal perirenal BAT (D–F, bar = 50 μm). (b) relative mRNA level of UCP1. (c) quantitative data in immunohistochemical analysis of UCP1. (d) western blot of UCP1. UCP1 protein expression of all samples was expressed as fold changes, calculated relative to the CG group. a,b Bars with different superscript differ (p<0.05). UCP1, uncoupling protein 1; H&E, hematoxylin and eosin.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271387-3-ab-21-0199f1.jpg"
} | 009017 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "(A) Histological analysis of Sus scrofa ileum under starvation stress. ICT is the control, IHT-48 indicates piglets subjected to starvation stress for 48 h, and IHT-72 is piglets subjected to starvation stress for 72 h. (B-D) Histogram comparing the length of the villi, depth of the crypt, and villi/crypt ratio in the ileum among the two treatments and the control (A–C indicates p<0.01).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271390-1-ab-21-0483f1.jpg"
} | 009018 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "(A) Giant LA mass macroscopic appearance after surgical removal. (B) Pathological evaluation showing concentric deposition of thrombus composed of nuclear debris, fibrin, and erythrocytes.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271426-1-gr5.jpg"
} | 009019 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "Transthoracic echocardiography: two-dimensional parasternal long-axis view showing LA mass (yellow arrow).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271426-3-gr3.jpg"
} | 009020 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "(A) Transesophageal echocardiography: two-dimensional midesophageal view showing giant LA thrombus. (B) Transesophageal echocardiography: three-dimensional zoomed midesophageal view demonstrating LA thrombus.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271426-4-gr4.jpg"
} | 009021 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "a Class II elastics engaged on the mesiobuccal surface of the mandibular first molar. b The 3D-printed button on the aligner",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271451-8-40510_2022_417_Fig1_HTML.jpg"
} | 009022 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "Continuous delivery of GSK-J4 to Pde6ccpfl1 retinal explants for 10 days allowed significant retention of cone photoreceptors, improved morphology, and localization of M- and S-opsins. A Schematic diagram showing the process of dissecting the retina from PN (Postnatal day) 14 Pde6ccpfl1 mice before growing retinal explants on culture membranes. Retinal explants were either sham-treated or treated with 10 µM of GSK-J4 daily for 10 days before collection at PN (Postnatal day) 24. B, C Representative cone arrestin (green) immunostaining and quantification of cone numbers in Pde6ccpfl1 retinal explants show significant protection of GSK-J4-treated cones compared to untreated explants. Welch’s T-test, n = 11 untreated, n = 12 treated, **P < 0.01. Scale bar 50 µm. ONL, outer nuclear layer. D M-opsin (red) and S-opsin (cyan) immunostaining showed an improvement of protein localization in the cones after treatment with GSK-J4. Scale bar 20 µm. ONL, outer nuclear layer. E An increase of H3K27me3 (magenta) staining was observed in Pde6ccpfl1 explants that had received GSK-J4 treatment (indicated by arrows) but not in untreated explants. Scale bar 20 µm. ONL, outer nuclear layer. Glyphos, glycogen phosphorylase. F The number of photoreceptor rows was unchanged between untreated and GSK-J4-treated groups. Welch’s T-test, n = 4, P > 0.05. G The average soma position of cones relative to the outer limiting membrane was significantly improved after administration of 10 µM GSK-J4. Welch’s T-test, n = 4, *P ≤ 0.05",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271452-4-18_2022_4436_Fig6_HTML.jpg"
} | 009023 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "(up) Assembly of the T3SS over time under a fluorescence microscope. Samples were taken every 2 h after incubation of Strain DL001 in secreting medium. (down) Assembly of the T3SS over time under the fluorescence microscope. cells containing foci were counted and divided by the total cell number. OD measurements are indicated above each column",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271453-5-203_2022_3068_Fig2_HTML.jpg"
} | 009024 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "(up) Effect of NaCl salt concentration on the PscQ foci and ExoS-mCherry synthesis of T3SS of P. aeruginosa. Strain (DL001 + pAD731) was imaged under fluorescence microscopy, GFP filter was used to study the PscQ foci and m-Cherry filter was used to study the ExoS-mCherry synthesis of T3SS. (down) (right) Effect of NaCl salt concentration on ExoS-mCherry synthesis and PscQ foci of T3SS of P. aeruginosa. Strain (DL001/pAD731) was imaged under fluorescence microscopy using an m-Cherry filter and GFP filter, cells with fluorescence were quantified. (left) Effect of NaCl salt concentration on the growth rate of P. aeruginosa strain DL001. Optical density (OD600) was recorded every 2 h for a 6 h period",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271453-6-203_2022_3068_Fig4_HTML.jpg"
} | 009025 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "(up) Images of fluorescence microscopy showing ExoS-mCherry synthesis of T3SS of P. aeruginosa using reporter plasmid pAD731. Strains were incubated in secreting medium for 3 h at 37 °C. (down). ExoS-mCherry synthesis and PscQ foci of T3SS of P. aeruginosa. The ExoS-mCherry synthesis was evaluated using T3SS reporter plasmid in strain DL001/pAD731",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271453-7-203_2022_3068_Fig3_HTML.jpg"
} | 009026 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "Differences in DC values in the cerebellum between the EB and SC groups. Yellow-red denotes higher DC values and green-blue denotes lower DC values in patients with EB compared to SCs. DC, degree centrality; EB, early blindness; SCs, sighted controls; L, left; and R, right.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271564-1-fnhum-16-935642-g003.jpg"
} | 009027 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "Neuroanatomical and functional networks relevant to ketamine's dissociate properties. (A) Map illustrating the relative anatomic position of the temporoparietal junction (TPJ) and the inferior parietal lobe (IPL). Maps are depicted on the flattened brain surface of the PALS atlas (109). Legend and image modified from Geng and Vossel (110) Figure 2 with permission under the terms of the Creative Commons Site License (https://creativecommons.org/licenses/by/4.0/). (B) Relevant structures that comprise the posterior medial cortex (PMC) as determined by whole-brain activation profiles. Image modified from Bzdok et al. (111) Figure 4 with permission. (C) Shown are two dissociated networks (A and B) near the default mode network (DMN) in a single subject. The dashed boxes highlight nine cortical zones where neighboring representations of the two networks were found, including: 1) dorsolateral prefrontal cortex (PFC), 2) inferior PFC, 3) lateral temporal cortex, 4) inferior parietal lobule (IPL) extending into the temporoparietal junction (TPJ), 5) posteromedial cortex (PMC), 6) midcingulate cortex, 7) dorsomedial PFC, 8) ventromedial PFC, and 9) anteromedial PFC. Note the proximity of zones 4 (TPJ/IPL) and 5 (PMC). Legend and image modified from Braga and Buckner (112) Figure 3 with permission under the terms of the Creative Commons Site License (https://creativecommons.org/licenses/by/4.0/). (D) Regions of interest that form the default mode network. Image modified from Krönke et al. (113) Figure 1 with permission.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271565-1-fpain-03-872696-g0003.jpg"
} | 009028 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "Lack of Rnd3 expression causes ultrastructure alterations in the subventricular zone (SVZ). (A) Electron microscopy (EM) images of microglial cells from Rnd3 deficient mice (Rnd3 KO, bottom panel) showing numerous lysosomes (arrows) and mitochondria, some of them with irregular morphologies (arrowheads) and lipid droplets accumulation (asterisks), when compared with wildtype samples (Rnd3 WT, top panel). Scale bar: 500 nm. (B) Quantitative analysis of the EM study of the subventricular zone (SVZ) of wildtype (WT) and Rnd3 deficient (KO) mice. Microglial cells were counted in three different levels of the SVZ (left), as described in Methods. Lysosome (middle) and mitochondria (right) density represent the number of either lysosomes or mitochondria per cell area. Plots represent the mean and standard error of the mean (SEM) of three independent samples (microglial cells) or all the microglial cells found (organelle density; WT, n= 23 cells; Rnd3gt/gt, n = 43 cells). No lipid droplets were found in WT samples and therefore this is not shown in the graphs. Unpaired t test shows statistical differences in the number of microglial cells (p = 0.0364) and lysosome density (p = 0.0196).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271580-3-fcell-10-834561-g001.jpg"
} | 009029 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "Localization of γ-tubulin and CEP290 in several stages of paraspermatogenesis. Several stages of parasperm were stained with anti-acetylated α-tubulin antibody (green), anti-γ-tubulin antibody (A–D, red), anti-CEP290 antibody (E–H, red), and DAPI. (A) γ-Tubulin first accumulates in the anterior region at the late round stage and then (B–D) decreases and becomes localized at the tip of anterior end. BF, bright field image. Bar, 10 μm. (E,F) CEP290 accumulates in the anterior region in the cone-shaped stage, (G) but its localization becomes obscure, and (H) is no longer apparent in mature parasperm. Bar, 10 μm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271582-0-fcell-10-905748-g013.jpg"
} | 009030 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "Differential interference contrast (DIC) images of S. luhuanus sperm. (A) Spermatogenic cells obtained from testis. Both immature eusperm and parasperm can be observed. Scale bar, 100 μm. (B) Mature sperm obtained from sperm duct. Six mature parasperm as well as many mature eusperm are shown. Scale bar, 100 μm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271582-1-fcell-10-905748-g002.jpg"
} | 009031 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Male reproductive system in S. luhuanus. (A) Adult S. luhuanus. Scale bars, 2 cm. (B) A copulating male and a female. Scale bars, 2 cm. (C) Insertion of the penis into the female tract. Scale bars, 1 cm. (D) H&E staining of S. luhuanus testis, which is clearly composed of many lobules (dashed line). Scale bars, 500 μm. (E) Both eusperm and parasperm are generated in a lobule. Parasperm and paraspermatogenic cells (arrows) are recognized as larger cells with less intense hematoxylin staining. Spermatids and mature sperm are recognized by packed nuclei intensely stained with hematoxylin (arrowheads). Scale bars, 100 μm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271582-10-fcell-10-905748-g001.jpg"
} | 009032 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "SEM images of (A–E) Parasperm at elongating stage. (F–I) Magnified images of distinct morphological regions during the elongating stage. The flagellar brushes are bundled at the anterior end. Scale bar (A–E), 10 μm and (F–I), 5 μm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271582-11-fcell-10-905748-g008.jpg"
} | 009033 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Cytoskeletal structure of the round- and cone-shaped stages of parasperm. Immunofluorescence microscopy was performed for (A–C) round stage and (D) cone-shape stage parasperm with anti-acetylated α-tubulin (axoneme, red) and anti-actin (cytoplasm, green) antibodies. DNA was stained with DAPI. Bar, 10 μm. (E–J) Thin-sectioned TEM image with (E,F) a number of axonemes passing through the center of the cytoplasm at the late round stage. (E) Cross section, (F) semi-longitudinal section. Bar, 5 μm. (G) Axoneme structures in the center of the cytoplasm and (H) those in the flagellar brushes with single axoneme. Bar, 500 nm. (I,J) At anterior region, bundles of the root structure with basal bodies (BB), transition zones (TZ), and striated rootlets (SR) can be observed. Bar, 1 μm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271582-12-fcell-10-905748-g010.jpg"
} | 009034 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Sequential images of parasperm (top to bottom) recorded at 200 fps in a forward swimming motion (yellow arrow). Images at 300 ms intervals are shown. Three waves (numbers above parasperm) propagated in the undulating membrane from the anterior to posterior end. (A) Anterior end and (P) posterior end. See Supplementary Video S1. Scale bar, 20 μm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271582-2-fcell-10-905748-g005.jpg"
} | 009035 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Cytoskeletal structure of mature parasperm. Cells were stained with anti-acetylated α-tubulin antibody (axoneme, red), anti-actin antibody (cytoplasm, green), and DAPI. (A) A front and lateral confocal image from 3D constructed data. Bar, 10 μm. (B–O) Thin-sectioned TEM images. (B) A cross and (C) a longitudinal section of a mature parasperm. (B) Two lateral undulating membranes and (C) both anterior and posterior end structures can be observed. Bar, 2 μm (B); 5 μm (C). Magnified images of (D) anterior and (E) posterior ends. Bar, 2 μm (D); 5 μm (E). (F) A longitudinal section of a parasperm showing a prominent edge at the anterior end. (G) Magnification of (F) showing that the projection at the anterior end is composed of basal bodies and striated rootlets. Bar, 2 μm (F); 1 μm (G). (H–J) Axonemal arrangements at the posterior end. Electron dense materials are seen as a streak in the center of the posterior end, where two arrays of axonemes are joined, with 9 + 0 structured axonemes frequently observed near the materials. Bar, 2 μm (H); 1 μm (I,J). (K–M) Magnification of the axonemes shows 9 + 2 structurers in the lateral region and 9 + 0 structures with both outer and inner arms located centrally near the dense materials. Bar, 200 nm (K); 100 nm (L,M). (N) A longitudinal section of the posterior end. Bar, 1 μm. (O–Q) A number of arrays of the axonemes with 9 + 0 structure are occasionally observed in the (O) lateral undulating membranes and (P) posterior end. Bar, 1 μm. (Q) The tip of the axonemes shows a collapsed structure. Bar, 500 nm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271582-3-fcell-10-905748-g012.jpg"
} | 009036 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Scanning electron microscope (SEM) images of (A–F) entire mature parasperm and (G–N) magnified images of distinct morphological regions. (F) Lateral view, (G,H) anterior round edge, (I–K) central areas with globular bodies, and (L–M) posterior streaked end. Scale bar in (A–F), 10 μm; (G–H,J,L), 2 μm; and (I,K,M,N), 5 μm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271582-4-fcell-10-905748-g004.jpg"
} | 009037 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "(A–G) The mature parasperm, including (H) a lateral view. Scale bar, 20 μm. (I,J) Some parasperm lacked globular bodies in the sharpened anterior end. Scale bar, 20 μm. (K,L) Typical parasperm have a round anterior edge with globular bodies. (M) Magnified anterior regions of (H) and (I) showing partial or complete loss of globular bodies. Green or red represents occupied or empty area for the globular bodies, respectively. Scale bar, 10 μm. (N,O) A posterior edge with a flattened end and streak structure. Scale bar, 20 μm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271582-5-fcell-10-905748-g003.jpg"
} | 009038 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Differential interference contrast (DIC) images of S. luhuanus sperm at several stages in spermatogenesis. (A–C) Round stage, (D–G) cone-shaped stage, and (H–L) elongating stage. Yellow arrowheads and magenta asterisks indicate the brush of multiple flagella and the streak of the flattened posterior end, respectively. Blue arrowheads show bundling of the brush in the elongating stage. Scale bar (A–E), 10 μm and (F–I), 5 μm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271582-7-fcell-10-905748-g007.jpg"
} | 009039 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Cytoskeletal structure of the cone-shaped and elongating stage parasperm. Cells were stained with anti-acetylated α-tubulin antibody (axoneme, red), anti-actin antibody (cytoplasm, green), and DAPI. Confocal images from 3D constructed data at different directions for (A) early and (B) late elongating stage parasperm. Bar, 10 μm. (C–F) Thin-sectioned TEM images. (C) A longitudinal section, showing the formation of the lateral undulating membrane with the brush at the anterior end. Bar, 5 μm. (D) Two undulating membranes are observed on the lateral side of the elongating parasperm. Bar, 5 μm. (E) Magnified image of the axonemes in the undulating membrane, showing alignment of axonemal direction. Green lines represent the plane of two singlet microtubules. Bar, 500 nm. (F–G) Structures at the (F) anterior and (G) posterior ends of an elongating parasperm. ST, striated rootlet. Magenta asterisk, electron dense materials. Scale bar, 500 nm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271582-8-fcell-10-905748-g011.jpg"
} | 009040 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Sequential images of parasperm (top to bottom) recorded at 200 fps in a backward swimming motion (yellow arrow). Images at 15 ms intervals are shown. Three waves (numbers above parasperm) propagated in the undulating membrane from the posterior to anterior end. (A) Anterior end and (P) posterior end. See Supplementary Video S2. Scale bar, 20 μm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271582-9-fcell-10-905748-g006.jpg"
} | 009041 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "The brain regions with a significant difference in patients with type 2 diabetes mellitus. (A) Significant difference in internal network connectivity in the SN. (B) Significant difference in internal network connectivity in the LECN. (C) Significant difference in internal network connectivity in the DMN. (D) Significant difference in internal network connectivity in the SN. (E) Significant difference in internal network connectivity in the precuneus network. The significance threshold was set at p < 0.05 (false discovery rate-corrected).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271612-0-fnins-16-887713-g002.jpg"
} | 009042 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Significant brain network regions are rendered on the surface of the automated anatomical labeling atlas in BrainNet Viewer. (A) Significant difference network connectivity in the left executive control network with the whole brain. (B) Significant difference network connectivity in the right executive control network with the whole brain. (C) Significant difference network connectivity in the precuneus network with the whole brain. The significance threshold was set at p < 0.05 (false discovery rate-corrected, cluster size > 20). R, right; L, left.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271612-3-fnins-16-887713-g003.jpg"
} | 009043 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Angiographic and ultrasonic features of extracranial vertebral artery stenosis. (A) Digital subtraction angiography shows severe lumen narrowing of the V1 segment of the vertebral artery; (B) Duplex ultrasonography shows high-velocity flow at the V1 segment; (C) Duplex ultrasonography shows tardus flow in the V2 segment. RVA, right vertebral artery; RSA, right subclavian artery; PSV, peak systolic velocity.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271613-2-fneur-13-814972-g0002.jpg"
} | 009044 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Pre- and postoperative radiographs for comparison of foot morphology. (A) The red dots represent the centers of the lateral metatarsal bones, and the green dots represent the centers of the medial metatarsal bones. The blue line represents the axis of the fifth metatarsal, and the yellow line represents the axis of the fourth metatarsal. (B) The blue line represents the axis of the fifth metatarsal bone after surgery. The blue dot represents the center of the fifth metatarsal bone after surgery; the sequence of the fifth toe line returned to normal after surgery.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271621-0-fped-10-931148-g0004.jpg"
} | 009045 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Intraoperative fluoroscopic images, immediate postoperative appearance and 1-year follow-up findings. (A) Intraoperative fluoroscopic radiographic images showing the fifth ray axis was restored and the wide forefoot was improved. (B) Immediate postoperative photos showing the appearance of the foot. (C) Photos showing the appearance of the operated foot at 1-year after surgery. (D) Radiograph showing good healing ang the fifth ray axis was restored, taken 1-year after surgery.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271621-1-fped-10-931148-g0003.jpg"
} | 009046 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Radiographic and schematic depiction of the surgical process. (A) Radiographic image depicting the lateral column and medial column osteotomy line. (B) Schematic diagram of the surgical process. The red shaded part represents the excised part.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271621-2-fped-10-931148-g0002.jpg"
} | 009047 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Postoperative morphological and radiologic characteristic of feet. (A) The appearance of left foot recovered well 1-year after operation, and the length of the fifth toe was the same as that of the unimpaired side. (B) The fifth digit column of left foot was lengthened. The postoperative length of the fifth metatarsal in the left foot was 39 mm and the fifth metatarsal in the right foot was 35 mm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271621-3-fped-10-931148-g0005.jpg"
} | 009048 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Postoperative medial and lateral arches of feet. (A) The height of the fifth metatarsal bone of left foot was 14.68 mm. (B) The medial arch of left foot was 114° and the lateral arch was 145°. (C) The height of the fifth metatarsal of right foot was 14.30 mm. (D) The medial arch of right foot was 118° and the lateral arch was 145°. The reconstructed lateral arch is similar to the unimpaired side.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271621-4-fped-10-931148-g0006.jpg"
} | 009049 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "RPE mitochondrial morphological changes detected by TEM 7 days after NaIO3 administration. (A) and (B) Representative TEM micrographs show decreased mitochondria numbers, loss of cristae, and mitochondrial vacuolization in the NaIO3 group; EC helped maintain normal mitochondrial morphology. Black BM indicates Bruch's membrane. White arrows indicate mitochondria. White N indicates nucleus. Magnification: 10,000 × (bar = 2 μm) and 20,000 × (bar = 1 μm), respectively. (C) Total number of mitochondria per field were increased in the EC group compared to the NaIO3 group. (D) Percentage of damaged mitochondria per field were decreased in the EC group compared to the NaIO3 group. (E) There was no apparent difference in size of mitochondria between the NaIO3 group and the EC group. Values are presented as mean with SEM; n = 4; n.s., no significance. **p < 0.01, ***p < 0.001, ****p < 0.0001.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271623-1-fmed-09-879901-g0007.jpg"
} | 009050 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Safety validation of EC on the retina of C57BL/6 mice. Representative images of (A) fundus photography, (B) OCT, and (C) HE stained sections show no lesions in the EC group, and there is no observable structural change between the two groups. (D) Quantification of the number of nuclei per μm in the ONL. GCL, Ganglion cell layer; INL, inner nuclear layer; ONL, outer nuclear layer; ELM, external limiting membrane; IS/OS, inner segment/outer segment; RPE, retinal pigment epithelium. Values are presented as the mean with SEM, n = 3; n.s., no significance. Scale bar: 50 μm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271623-3-fmed-09-879901-g0001.jpg"
} | 009051 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "EC protects against retinal degeneration caused by NaIO3 administration. (A) The ONL underwent deformation by day 7 after NaIO3 administration, but this damage was ameliorated by EC treatment. Yellow arrows indicate drusen-like melanin deposits. (B) The total area of drusen-like deposits tended to be smaller and reduced in the EC group. (C) The number of nuclei per μm in the ONL was significantly increased in the EC group. (D) Thickness of the ONL and (F) IS/OS layers were measured at 150 μm intervals from the optic nerve head (#, Control vs. NaIO3 group; *, NaIO3 vs. EC group). (E) Mean thickness of the ONL and (G) IS/OS layers. GCL, Ganglion cell layer; INL, inner nuclear layer; ONL, outer nuclear layer; IS/OS, inner segment/outer segment; RPE, retinal pigment epithelium. Values are presented as mean with SEM, n = 4; n.s., no significance; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Scale bar: 50 μm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271623-5-fmed-09-879901-g0002.jpg"
} | 009052 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "EC reduced outer retinal degeneration induced by NaIO3 administration. (A) Representative color fundus photographs taken at day 7 post-NaIO3 administration showed that EC reduced the number of yellow-white deposits. Black arrows indicate drusen-like deposits. (B) Color fundus photographs were converted to gray scale with retinal degeneration areas show in white. (C) The percentage of retinal degeneration (degeneration area/total area) were quantified. (D) Representative OCT images showed EC reduced hyperreflective foci in the outer retinal layers. White arrows indicate high reflex lesions. GCL, Ganglion cell layer; INL, inner nuclear layer; ONL, outer nuclear layer; ELM, external limiting membrane; RPE, retinal pigment epithelium. Values are presented as mean with SEM; n = 4 or 5. ***p < 0.001, ****p < 0.0001; Scale bar: 50 μm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271623-8-fmed-09-879901-g0003.jpg"
} | 009053 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "(A) Loss of IDE expression reduces ciliated α-cells number. Representative epifluorescence microscopy (40X zoom) images of cilia signal in siRNA-Ide- and control-treated α-cells. Acetylated α-tubulin (green) and DAPI (blue). Asterisks indicate the presence of cilia. (B) Primary cilium and proliferation in α-cells. Representative fluorescence microscopy images of cilia signal obtained with confocal microscopy (60X zoom) in non-permeabilized α-cells. As seen in the images, proliferation (BrdU staining) was associated with unciliated cells. Acetylated α-tubulin (green), DAPI (blue), and BrdU (red).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271624-1-fendo-13-922825-g004.jpg"
} | 009054 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Met treatment attenuated HFD-induced CH. (A) Heart morphology. (B) Heart weight/femur length. (C) HE staining of heart tissue (scale bar: 50 µm). (D) Quantification of cardiomyocyte size. (E,F) mRNA expression levels of ß-MHC and ANP. Graphs represent mean ± SEM (n = 6). *\np < 0.05, **\np < 0.01.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271627-1-fphar-13-919202-g002.jpg"
} | 009055 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Activation of PPAR-γ abolished the protective effect of Met on CH in rat cardiomyocytes. (A) H9c2 cells were subjected to an immunofluorescence assay with anti-ANP and anti-α-actin antibodies (scale bar: 20 µm). (B) Detection of apoptotic cells by TUNEL staining (scale bar: 100 µm). (C) Quantitative data of ANP fluorescence intensity analyzed by Image-Pro Plus 6.0 software. (D) Quantification of apoptotic cells. Graphs represent mean ± SEM (n = 3). **\np < 0.01, ***\np < 0.001.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271627-7-fphar-13-919202-g006.jpg"
} | 009056 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Random effects group analysis of the facial smiling task. Activations (one sample t-test, p < 0.05, FDR corrected) in response to blocked (15 s) movement of the bilateral mouth angle are shown superimposed on a template cortex. Images from the control group (n = 15) are shown in the upper part of the figure, while images from the patients (n = 22) are shown in the lower part. PoCG, postcentral gyrus; PreCG, precentral gyrus; SMA, supplementary motor area; MFG, middle frontal gyrus; MTG, middle temporal gyrus; R, right; L, left; FP, facial paralysis patients; HC, healthy controls. Color bar shows the t-value.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271667-4-fnins-16-943919-g002.jpg"
} | 009057 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "Active sleep resistance group differences. Axial slices displaying significant activation clusters that were significantly more activated in people with narcolepsy type 1 than in controls during active sleep resistance. Analyses were cluster-corrected (p < 0.05), masked for gray matter, and a minimum cluster size > 20 voxels was used.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271668-0-fnins-16-904820-g002.jpg"
} | 009058 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "Main task effect activation clusters. Axial slices displaying significantly activated voxels in the “active sleep resistance > waking rest” contrast over all subjects. Analyses were cluster-corrected (p < 0.05), masked for gray matter, and a minimum cluster size > 20 voxels was used.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271668-1-fnins-16-904820-g001.jpg"
} | 009059 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "Representation of healthy stomach compartments, and different gastric disorders induced by H. pylori. (a) normal body. (b) normal antrum. (c) normal duodenum. (d) antral gastritis. (e) duodenal ulcer. (f) gastric ulcer. (g) gastric cancer. (h) esophagitis. (i) polypoid lesion in the antrum.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271669-6-fphar-13-917184-g001.jpg"
} | 009060 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "MRI findings of an 18-year-old male with HLA-B27 positive ankylosing spondylitis at baseline (A) and 6-month follow-up (B). Coronal oblique T1 images show new ‘backfill’ at the right sacroiliac joints (white arrows) after 6-month follow-up.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271670-1-fimmu-13-887470-g002.jpg"
} | 009061 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "MRI findings of a 38-year-old female with HLA-B27 negative axial spondyloarthritis at baseline (A) and 12-month follow-up (B). Coronal oblique T1 images show fat metaplasia at both sacroiliac joint surfaces, however, no backfill occurs after 12-month follow-up.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271670-2-fimmu-13-887470-g003.jpg"
} | 009062 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "FcγRI does not contribute to immune cell infiltration in mouse DRG in the late phase of CAIA. (A) Representative image of mouse DRG sections from Fcgr1+/+\n and Fcgr1-/-\n mice on day 56 after CAIA. DRG sections were stained for CD3, Ly6C/G, CD68 and NeuN. Scale bar, 50 μm. (B–D) Quantification showed an increase in the number of CD3+ (B; n = 8-10 mice/group) and Ly6C/G+ (C; n = 6-10 mice/group) cells per unit area but not the mean fluorescent intensity of CD68+ (D; n = 6-7 mice/group) per unit area in the DRG of either genotype on day 56 after CAIA induction. Yet, no obvious differences in CD3+ or Ly6C/G+ cell infiltration were observed between genotypes. *p < 0.05, **p < 0.01 versus Ctrl, two-way ANOVA followed by Bonferroni post hoc test. n.s., not significant.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271677-0-fimmu-13-889286-g007.jpg"
} | 009063 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "FcγRI mRNA expression is upregulated in DRG neurons in the postinlfammatory phase of CAIA. (A) Representative lumbar DRG ISH for Fcgr1 and immunostaining for CGRP and NeuN from control and CAIA mice on day 56 after challenge. Scale bar, 50 μm. (B) Percentage of Fcgr1\n+ neurons among all DRG neurons in control (Ctrl) and CAIA mice. n = 7-8 mice per group; *p < 0.05 versus control; unpaired Student’s t test. (C) Size frequency distribution of Fcgr1 mRNA expression in each cell size population in DRG neurons of control and CAIA mice on day 56 after immunization. n = 7 mice per group; *p < 0.05, **p < 0.01 versus Ctrl; unpaired Student’s t test. (D) Percentage of CGRP+ neurons among all DRG neurons in control and CAIA mice. n = 8-9 mice per group; p > 0.05 versus Ctrl; unpaired Student’s t test. (E) Percentage of Fcgr1+\n neurons among CGRP+ neurons in control and CAIA mice. n = 8-9 mice per group; P > 0.05 versus Ctrl; unpaired Student’s t test. (F) Percentage of CGRP+ neurons among Fcgr1+\n neurons in control and CAIA mice. n = 8-9 mice per group; *p < 0.05 versus Ctrl; unpaired Student’s t test. n.s., not significant.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271677-2-fimmu-13-889286-g006.jpg"
} | 009064 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "FcγRI is not necessary for cartilage destruction in the postinflammatory phase of CAIA. (A) Representative images of Safranin O/fast green-stained ankle joints from Fcgr1+/+\n and Fcgr1-/-\n mice on day 56 after CAIA. Arrowheads indicated cartilage destruction. Scale bar, 200 μm. (B) No obvious differences in the histology score for cartilage destruction were observed at day 56 after CAIA between genotypes. n = 4 - 6 mice/group; *p < 0.05; **p < 0.01 versus control (Ctrl), two-way ANOVA followed by Bonferroni correction. n.s., not significant.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271677-5-fimmu-13-889286-g002.jpg"
} | 009065 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Transmission electron microscopy image of Ac42AzGlc encapsulated PLGA nanoparticles prepared to employ improvised nanoprecipitation method. Zoomed image has also been shown.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271679-5-fbioe-10-833456-g011.jpg"
} | 009066 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Evaluation of apoptosis protection in UVB-irradiated L929 fibroblasts treated with DPFRHY. (A) DNA condensation formation was observed under a fluorescence microscope following Hoechst 33342 staining. (B) The units statistics of DNA condensation in each field of microscope.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271680-4-fbioe-10-908033-g011.jpg"
} | 009067 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "The potential of SSCH-L to repair skin damage in zebrafish exposed to UVB. (A). UVB-induced malformed fin phenotypes can be attenuated by SSCH-L. (B). Quantification of fin phenotypes. (C). Schematic representation of the zebrafish experimental protocols performed in this study.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271680-6-fbioe-10-908033-g009.jpg"
} | 009068 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Histone molecular-specific structural disorder by confocal-IPR: (a)–(b) the confocal images of the PF and EF H3K27me3-stained pup brain cells targeting histone, and (a′)–(b′) represent their respective ⟨IPR⟩ images. (c) The ⟨IPR⟩ values or the degree of structural disorder at sample length L=0.8 μm for PF H3K27me3-stained and EF H3K27me3-stained pup brain cells are presented. The ⟨IPR⟩ value for PF H3K27me3-stained brain cells was found to be lower compared to that of the PF H3K27me3-stained brain cells. The percentage difference of the ⟨IPR⟩ values for structural disorder between these two groups is 10%. (Student t-test, P-value<0.05 PF mice (n=5) and EF mice (n=5), 3 to 5 samples per mouse.)",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271689-2-JBO-027-076002-g003.jpg"
} | 009069 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Increased and decreased activation of PMS patients' brain regions than healthy controls when processing depression vs. neutral pictures. (A) Depicts overall activation of the brain area by negative emotional picture task in PMS patients. (B) Manifests bilateral temporal lobe. (C) Illustrates bilateral precuneus, posterior cingulate, and cuneiform. (D) Demonstrates the brain areas activated in motor areas. Red indicates enhanced activation of brain regions in PMS patients, while blue indicates that activation is decreased.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271695-1-fpsyt-13-856443-g0002.jpg"
} | 009070 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "The regions of the basolateral amygdala [basolateral amygdala (BLA): –2.8 mm from bregma] and central amygdala [central amygdala (CeA): –2.8 mm from bregma]. The cannula was placed into them as shown in the rostral faces of each coronal section.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271698-0-fnmol-15-932939-g001.jpg"
} | 009071 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Schematic structure and early invasion of the SARS-CoV-2 coronavirus. (A) This simplified outline of the viral unit shows its two essential components: “A” indicates the outer spikes (S protein, main antigen units) and “B” indicates the inner single-stranded RNA (the genetic viral genome). (B) Electron microscopy imaging showing coronavirus invasion (multiple round units, in blue) inside the pulmonary alveolar spaces and interstitial cells. Source: (A) Design Cells/Shutterstock and (B) Centers for Disease Control and Prevention, Public Health Image Library. ID# 23354; Hannah A. Bullock; Azaibi Tamin (2020); https://phil.cdc.gov/Details.aspx?pid=23354.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271702-0-fcvm-09-919715-g001.jpg"
} | 009072 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Typical angiographic imaging of the coronary arteries in a patient with a dobutamine-related 4 mm ST-elevation acute ischemic event. (A) At baseline, mild diffuse narrowing of all left coronary artery branches was observed. (B) After intracoronary acetylcholine infusion, severe and diffuse narrowing appeared, with almost total occlusion of all left coronary artery branches (with chest pain, electrocardiogram changes, and recurrent cardiomyopathy on echocardiography; not shown). (C) Immediately after intracoronary nitroglycerin administration, the spasm was relieved. We concluded that coronary endothelial dysfunction was present at baseline and that spasm was stimulated by initial dobutamine testing (outside our hospital) as well as after acetylcholine testing.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271702-1-fcvm-09-919715-g006.jpg"
} | 009073 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Histological findings in patients with COVID-19. (A) Microthrombi (arrowheads) in the pulmonary perialveolar small vessels (12). Hematoxylin-eosin staining; the scale bar corresponds to 50 μm. (B) Megakaryocyte-related (arrow) small vessels in the myocardium of a patient with a small myocardial necrotic injury. Fibrin thrombosis in a perforating vein associated with a myocardial infarction shows transmural myocardial necrosis and neutrophilic infiltrates (15). Source: (A) Ackermann et al. (12). Used with permission. (B) Rapkiewicz et al. (15). Reproduced under Creative Commons license CC-BY-NC-ND. https://creativecommons.org/licenses/by-nc-nd/4.0/.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271702-3-fcvm-09-919715-g003.jpg"
} | 009074 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Impaired interactions between neutrophils and T-cells in TDLNs. (A, B) Tumor decreases the number of interactions between neutrophils and T-cells in LNs of tumor-bearing WT (A) and Ifnar1-/-\n(B) mice. Exemplified pictures showing TDLN neutrophils in red (tdTomato), T-cells in green (FITC), and LNs tissue in grey (autofluorescence). Corresponding movies available in supplements. Scale bar 30 µm. The white arrows indicate the neutrophil that interacts with T-cell. (C) Growing primary tumor impairs interactions between neutrophils and T-cells in TDLNs of tumor-bearing animals, especially in Ifnar1-/-\n mice, in comparison to tumor-free animals (interactions were estimated during 15 minutes and normalized per one neutrophil, in an in vivo system). (D–J) Significantly reduced T-cell activation in TDLNs in Ifnar1-/-\n mice, estimated by Ki-67 expression on TDLN cryo-sections (D) and flow cytometry for all T Lymphocytes (E) and for both CD8 and CD4 subpopulations (G–J). (F) Representative histograms showing down-regulated expression of Ki-67 in CD4 and CD8 cells of tumor-bearing Ifnar1-/-\n mice in comparison to WT mice. (K, L) Impaired IFN-ɣ expression in CD4 (K) and CD8 (L) cells in TDLNs of Ifnar1-/-\n. (M, N) Suppressed T-cell activation after co-incubation with Ifnar1-/-\n TDLN neutrophils visualized by IFN-γ production in both CD4 (M) and CD8 (N) cell populations, in an in vitro setting. For (A–C) tumor cells were injected s.c. into the flank of mice. Two-photon microscopy of the previously surgically exposed inguinal TDLNs was performed on day 14. Cell interactions were manually counted in ROIs over the duration of 15 minutes. Representative results from six replicate experiments are shown for (A, B), n=5 for WT animals, n=8 for WT tumor-bearing animals, n=5 for Ifnar1-/-\n animals, n=8 for Ifnar1-/-\n tumor-bearing animals. For (D–J, K, L) tumor cells were injected s.c. into the flank of mice. Mice were sacrificed on day 14 post tumor induction, LNs were collected, immunofluorescent histological staining (quantification of CD3+ and CD3+Ki67+ cells, 10 fields of view 1mm2) (D) and flow cytometry (Ki67 expression on single alive CD3+, CD3+CD4+ and CD3+CD8+ cells) (E–G) were performed. Representative results are shown for thee experiment for (D), n=10 for each cohort and for three experiments for (E), n=5 for each cohort and three replicate experiments. Representative results are shown for two replicate experiments for (G–J), n=5 for each cohort. For (M, N) tumor cells were injected s.c. into the flank of mice. Mice were sacrificed on day 14 post tumor induction, LNs were collected and neutrophils (single alive Ly6G+ CD11b+ cells) were isolated using flow sorting. T-cells (single alive CD3+ cells) were isolated from the spleens of naïve WT mice using flow sorting and co-incubated with neutrophils. On day 3 the intracellular expression of IFN-ɣ in single alive CD4+ and CD8+ cells was estimated by flow cytometry. Representative results are shown for two experiment for (M), n=4 for each cohort and two replicate experiments for (N), n=5 for WT, n=7 for Ifnar1-/-\n. For comparison of two independent groups, Mann-Whitney U test was used. Data are shown as an individual values with median. *p < 0.05, **p < 0.01, ***p < 0.005.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271705-2-fimmu-13-878959-g004.jpg"
} | 009075 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "miR-140-5p expression during adipocyte differentiation. (A) Expression of miR-140-5p at 24, 48, and 72 h during differentiation of preadipocytes treated with differentiation cocktail or DMI based on qRT-PCR. miR-140-5p expression in this study was normalized with U6 as the internal control. (B) miR-140-5p expression at diverse time points (1 day before differentiation, 0, 1, 2, 3, 5, and 7 days) during differentiation of preadipocytes. 3T3-L1 cells were inoculated with differentiation cocktail or DMI based on qRT-PCR. (C) Oil red O staining of preadipocytes at diverse time points (1, 2, 3, 5, and 7 days) during differentiation (100-fold magnification). Data are given as mean ± SD (n = 3, with three replicates in one independent experiment). Remarkable difference is given at the levels of *p < 0.05, **p < 0.01, and ***p < 0.001 via two-tailed Student’s t test.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271708-0-fmolb-09-907148-g001.jpg"
} | 009076 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Influence of PDGFRα on adipogenesis-linked gene expression and lipid droplet synthesis in 3T3-L1 cells. (A) qRT-PCR analysis of the expression of adipogenesis-associated genes after transfection with pEGFP-N1-PDGFRα (PDGFRα) or control in 3T3-L1 cells. (B) Western blotting analysis of the expression of adipogenesis-associated transcription factors after transfection with pEGFP-N1-PDGFRα (PDGFRα) or control in 3T3-L1 cells. (C) Illustrative images of oil red O after transient transfection with pEGFP-N1-PDGFRα (PDGFRα) or control (100-fold magnification) in 3T3-L1 cells.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271708-1-fmolb-09-907148-g004.jpg"
} | 009077 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Adipogenesis regulation via miR-140-5p as the adipogenic factor. (A) Expression levels of miR-140-5p and adipogenic genes after transient transfection with negative control mimics (Control) or miR-140-5p mimics in 3T3-L1 cells based on qRT-PCR analysis. (B) Western blot assessment of expression level of adipogenesis-linked genes after 3T3-L1 cells were transfected with miR-140-5p mimics, as well as control mimics. (C) Oil red O staining of 3T3-L1 cells in cell transfects of miR-140-5p mimics and control mimics (100-fold magnification). (D) Expression levels of miR-140-5p in 3T3-L1 preadipocytes transfected with miR-140-5p inhibitors (Inhi-miR-140-5p) and negative control (Control) based on qRT-PCR analysis. (E) Adipogenesis-linked gene protein content in 3T3-L1 cell transfects of miR-140-5p inhibitor or control inhibitor. (F) Oil red O staining of preadipocytes—3T3-L1 in the miR-140-5p inhibitor transfection group (Inhi-miR-140-5p) and control group (100-fold magnification).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271708-3-fmolb-09-907148-g002.jpg"
} | 009078 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Increase in adipocyte differentiation-related gene expression and enhancement in lipid droplet synthesis by PDGFRα knockdown. (A) qRT-PCR along with Western blot assays of PDGFRα expression after transfection of 3T3-L1 cells with PDGFRα siRNA 1(Si-PDGFRα1), PDGFRα siRNA 2(Si-PDGFRα2), and PDGFRα siRNA 3(Si-PDGFRα3), respectively. (B) Western blot assessment of the expression of adipocyte differentiation-related transcription factors after being transfected with PDGFRα siRNA (Si-PDGFRα) or control in 3T3-L1 cells. (C) RT-PCR analysis of mRNA expression of adipocyte differentiation-related genes after transfection with PDGFRα siRNA (Si-PDGFRα) or control in 3T3-L1 cells. (D) Illustrative images of oil red O after transient transfection with PDGFRα siRNA (Si-PDGFRα) or control in 3T3-L1 cells (100-fold magnification).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271708-4-fmolb-09-907148-g005.jpg"
} | 009079 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Differences in DC value between CAD patients and HC. Blue represents the decreased DC values in the right hippocampus (hippocampus_R) and right lingual gyrus (lingual_R). Red represents increased DC values in the left middle frontal gyrus (Frontal_Mid_L).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271740-0-fnagi-14-786253-g001.jpg"
} | 009080 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Side to side comparison MRI flair day 1 (A), day 6 (B), day 14 (C) and day 45 (D). The follow-up MRIs shows a gradual reduction of the initially displayed leptomeningeal enhancement in the left temporal, parietal and occipital lobes. The substance defect after astrocytoma excision appears as a liquid-filled black cyst in the lower part of the right hemisphere (left-sided in the pictures).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271741-1-fneur-13-887287-g0001.jpg"
} | 009081 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "XRD patterns of products in different (A) reaction temperatures and (B) reaction stages. SEM images of (C) natural sepiolite and (D) SNF showing 1D nanofiber morphology (Yellow ring marks material pores).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271742-0-fchem-10-932650-g002.jpg"
} | 009082 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "(A) XRD patterns of pre-pickling sepiolite and final product from pre-pickling sepiolite. (B) SEM of pre-pickling sepiolite showing 1D nanofiber morphology. (C,D) SEM and (E,F) TEM of the final product showing nanosphere morphology.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271742-2-fchem-10-932650-g004.jpg"
} | 009083 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "(A) TEM and (B) magnified TEM of natural sepiolite showing 1D nanofiber morphology. Morphological characterization of SNF, (C) TEM, (D) magnified TEM, (E) HRTEM, and (F) the corresponding SAED pattern (Yellow ring marks material pores).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271742-3-fchem-10-932650-g003.jpg"
} | 009084 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Schematic overview of the image registration and motion quantification steps. Abbreviations: cor: coronal, sag: sagittal, tra: transverse, dyn: dynamic slice, LN: lymph node, ROI: region of interest.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271760-0-gr1.jpg"
} | 009085 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Diagnosis of PCa using mpUS—case 1. A 68-year-old patient has a total serum PSA of 10.4ng/ml. The T2-weighted sequence of MRI (A, arrow) shows a slightly low signal shadow in the peripheral zone of the prostate, suggesting PCa in the diagnosis. The lesion showed a slightly hypoechoic area on the B-mode (B, arrow), and it’s not clearly demarcated from the seminal vesicle gland. CDU shows an abnormally increased blood flow in the lesion (C, arrow). TRTE shows that the slightly hypoechoic area of the prostate’s peripheral zone is highly stiff (D, arrow). CEUS shows early high enhancement within the lesion (E, arrow). TRUS-guided systematic biopsy confirmed that the peripheral zone of the prostate was a Gleason 4 + 4 PCa.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271763-0-fonc-12-905087-g001.jpg"
} | 009086 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "CT scan demonstrating (A) HSC-FND on coronal imaging, (B) normal HSC and facial nerve anatomy on coronal imaging, (C) HSC-FND on Poschl imaging, and (D) normal HSC and facial canal on Poschl imaging.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271764-0-fneur-13-879149-g0001.jpg"
} | 009087 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Multiplex immunofluorescence and colocalization examples. (A) CD3+ expression (red) on a lymphocyte T. (B) CD8+ expression (pink) of the same lymphocyte T in example (A). (C) CD3+ and CD8+ expression and colocalization (red and pink) for a cytotoxic T lymphocyte. (D) CD3+ expression (red) on a lymphocyte T. (E) PD1+ expression (green) of the same lymphocyte T in example (D). (F) CD3+ and PD1+ expression and colocalization (red and green) for a T lymphocyte PD1+. (G) Cytokeratin+ expression (cyan) of an epithelial tumor cell. (H) PDL1+ expression (orange) of the same epithelial tumor cell on example (G). (I) Cytokeratin+ and PDL1+ expression and colocalization (cyan and orange) on an epithelial tumor cell expressing PDL1 on its surface for immune evasion. Composite image from inform ® image analysis software, Akoya bioscience. Scanner Vectra Polaris.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271766-0-fonc-12-889886-g007.jpg"
} | 009088 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "egion of Interest and Image Preparation for Multiplex Analysis Using Tyramide Signal Amplification. Representative digital image of non-small cell lung cancer for multiplex immunofluorescence phenotyping analysis (10x – scale bar: 500 μm). (A) Hematoxylin & Eosin (H&E) (representative H&E image view provided by the software during analysis). (B) Multiplex immunofluorescence image view for ROI (composite image). (C) Multiplex immunofluorescence image on intratumoral region with training regions for tissue segmentation, red (tumor), green (stroma), blue (glass). (D) Region on interest (intratumoral) after training algorithm for tissue segmentation, red (tumor), green (stroma), blue (glass). Composite image from inForm ® image analysis software, Akoya bioscience. Scanner Vectra Polaris.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271766-1-fonc-12-889886-g001.jpg"
} | 009089 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Algorithm Workflow of Multiplex immunofluorescence Digital Image Analysis. After image scanning, raw images (A) are prepared by activating the fluorochromes attached to the different cell surface proteins (B). Then, for tissue compartmentalization, the software user can select the most representative examples of each compartment used during the training algorithm and exclude areas of disinterest (C). Once the tissue compartment algorithm is applied and the areas are defined (D), the next step is to define the cells limits (E) as individual objects to count for the analysis. The final part of the image analysis algorithm is the classification of the cells based on their phenotypes according to their surface protein expression (F). Images examples from inForm ® image analysis software. Akoya Biosciences.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271766-2-fonc-12-889886-g006.jpg"
} | 009090 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Multiplex Immunofluorescence. Image Analysis Overview. (A) Tumor and Stroma H&E image before preparation with multiplex fluorochromes. (B) Composite image, before algorithm analysis. (C) Tissue compartmentalization, tumor (red), stroma (green). (D) Nuclear detection and nuclear segmentation in both compartments (tumor and stroma). (E) Phenotyping map. (F) Complete algorithm visualization, including tissue segmentation, nuclear detection, cell segmentation and phenotyping. Composite image from inForm ® image analysis software, Akoya bioscience (scale bar: 100 μm). Scanner Vectra Polaris.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271766-3-fonc-12-889886-g008.jpg"
} | 009091 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Multiplex immunofluorescence T lymphocytes panel. As on the activation panel, the T lymphocytes panel includes a universal biomarker for nuclear detection (DAPI) and cytokeratin for detection of epithelial cells (malignant cells), which is also helpful for compartmentalization of the image (tumor vs. stroma). T lymphocyte populations are detected using CD3+ for all lymphocytes, co-expressed CD8+ for cytotoxic T cells, and co-expressed FOXP3+ for regulatory T-cells. This panel includes granzyme B+ (GB) and CD45RO+ to identify activated T-cells and memory T-cells, respectively. (A) Composite image of TME from oral squamous cell carcinoma, showing all markers of a multiplex immunofluorescence “T lymphocytes phenotypes”, activated simultaneously. (B) Composite image showing CD45RO positive expression (yellow) of immune cells in the stromal compartment. (C) Composite image showing FOXP3 positive expression (green) of immune cells in the stromal compartment. (D) Composite image showing CD3 positive expression (red) of immune cells in the stromal compartment. (E) Composite image showing CD8 positive expression (pink) of immune cells in the stromal compartment. (F) Composite image showing GB positive expression (magenta) of immune cells in the stromal compartment. inForm ® image analysis software, Akoya bioscience (scale bar: 100 μm). Scanner Vectra Polaris. DAPI (blue-DAPI), cytokeratin (cyan-opal 620), CD3+ (red-opal 690), CD8+ (pink-opal 540), CD45RO+ (yellow-opal 520), FOXP3+ (green-opal 650), Granzyme B+ (magenta-opal 570).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271766-4-fonc-12-889886-g005.jpg"
} | 009092 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Multiplex immunofluorescence activation panel. The activation panel includes a universal biomarker for nuclear detection (DAPI) and cytokeratin for the detection of epithelial cells (malignant cells), which is also helpful for the compartmentalization of the image (tumor vs. stroma). TME and its different immune cell populations are detected using CD3+ for all lymphocytes and co-expressed CD8+ for cytotoxic T cells. Biomarker CD68+ identify macrophage population. This panel also includes biomarker expression for PD1+ and PDL1+ in immune cells and tumor cells to determine their activator or inhibitor status. (A) Composite image of TME from oral squamous cell carcinoma, showing all markers of a multiplex immunofluorescence “activation panel”, activated simultaneously. (B) Composite image showing CD68 positive expression (yellow) of immune cells in the stromal compartment. (C) Composite image showing PD1 positive expression (green) of immune cells in the stromal compartment. (D) Composite image showing CD3 positive expression (red) of immune cells in the stromal compartment. (E) Composite image showing CD8 positive expression (pink) of immune cells in the stromal compartment. (F) Composite image showing PD-L1 positive expression (orange) of immune cells in the stromal compartment. inForm ® image analysis software, Akoya bioscience (scale bar: 100 μm). Scanner Vectra Polaris. DAPI (blue-DAPI), cytokeratin (cyan-opal 620), CD3+ (red-opal 690), CD8+ (pink-opal 540), CD68+ (yellow-opal 520), PD1+ (green-opal 650), PD-L1+ (orange-opal 570).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271766-7-fonc-12-889886-g004.jpg"
} | 009093 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Chest CT imaging findings of adenovirus pneumonia. (A) Right upper lung consolidation with bronchial inflation sign; (B) left emphysema; (C) double lung mosaic sign; (D) right lower lung bronchial wall thickening and surrounding lobule inflammation; (E) right Middle lung bronchiectasis; (F) a small amount of pleural effusion on the right.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271770-0-fped-10-874822-g002.jpg"
} | 009094 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Immunohistochemical staining of lung adenocarcinoma (LUAD) specimens. (A) Immunostaining images of POSTN in the adjacent normal tissues. Scale bar = 100 μm. (B) The distribution of POSTN in the LUAD tumor tissues in interstitial cells was denser than that in cancer cells. Scale bar = 100 μm. (C) The expression of POSTN in tumor tissues was higher than that in the adjacent normal tissues (p < 0.0001). (D) Immunohistochemical staining of CD34, which was used to mark endothelial cells and to count microvessel density (MVD) in the adjacent normal tissues. Scale bar = 100 μm. (E) Distribution of CD34 in the LUAD tumor tissues. Scale bar = 100 μm. (F) The expression of MVD in the LUAD tissues was higher than that in the adjacent normal tissues (p < 0.0001). (G) The correlation analyses revealed that the POSTN expression was positively correlated with MVD in lung adenocarcinoma.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271775-8-fonc-12-699824-g003.jpg"
} | 009095 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "By immunohistochemistry, the stromal cells showed positivity for (A) EMA (focal) (case 1, ×100), (B) desmin (focal) (case 5, ×120), and (C) CD68 (diffuse) (case 7, ×80), with the latter two displaying a dendritic cytoplasmic expression pattern. (D) The expression of Rb protein is retained in all cases analyzed (case 2, ×100).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271777-1-fonc-12-900411-g004.jpg"
} | 009096 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Uncommonly seen features include (A) sheets of small round cells separated by a thin-walled vascular network (case 8, HE ×120), (B) scattered degenerative nuclear atypia (case 7, HE ×200), (C) ischemic cystic change (case 2, HE ×100), and (D) foci of prominent neutrophil infiltration (case 3, HE ×200).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271777-2-fonc-12-900411-g003.jpg"
} | 009097 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "At low power, (A) the tumors are well-circumscribed and partially encapsulated (case 6, HE ×15) and (B) show a vaguely lobulated pattern of alternating hypocellular, myxoid, and more cellular collagenous areas (case 8, HE ×40). (C) Foci of tumor cells infiltration into the surrounding fibroadipose tissues are noted (case 3, HE ×100). (D) Prominent vascular network consisting of innumerable, small, thin-walled, frequently slit-like or branching blood vessels (case 8, HE ×120). (E) The calibers of the thin-walled blood vessel are sometimes opened and rounded (case 2, HE ×150). (F) Foci of plexiform delicate vascular network reminiscent of “chicken wire”-like capillaries characteristic of myxoid liposarcoma are observed; however, the tumor cells are mostly spindle-shaped with bland nuclei, contrasting sharply to the uniform round cells with small lipoblasts in myxoid liposarcoma (case 4, HE ×200). (G) Medium- to large-sized blood vessels with prominent staghorn morphology are commonly seen in four cases (case 5, HE ×100). (H) The tumor cells have inconspicuous palely eosinophilic cytoplasm and short ovoid or tapering nuclei, with irregular contours, fine chromatin, and indistinct nucleoli (case 8, HE ×200).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271777-3-fonc-12-900411-g002.jpg"
} | 009098 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "By fluorescence in situ hybridization analysis, (A) seven of the eight cases analyzed show NCOA2 gene rearrangement (case 4), (B) and the remaining one has increased gene copy numbers of intact NCOA2 (case 2). (Insets in A and B indicate schematic diagram of break-apart probes flanking NOCA2). Rearrangements involving (C)\nFUS (case 7)and (D)\nDDIT3 (case 3) are not identified in any of the cases examined. (Insets in C, D indicate a schematic diagram of break-apart probes flanking FUS and DDIT3, respectively).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271777-4-fonc-12-900411-g005.jpg"
} | 009099 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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