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stringlengths 57
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stringclasses 125
values | h
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dict |
|---|---|---|---|
the absorption , distribution , excretion and metabolism of pindolol were studied in rhesus monkeys after a single oral dose of 2.5 mg/kg or 25 mg/kg and after a chronic treatment of 5 years at the same daily dosage . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
32,
41
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
46,
56
]
} |
1-hexylcarbamoyl-5-fluoro [ 6-14c ] uracil ( 14c-hcfu ) administered orally to rats , rabbits and dogs at a dose of 20 mg/kg was well absorbed and rapidly excreted via the kidney . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
36,
42
]
} | {
"id": "C0016360",
"name": "hcfu",
"pos": [
49,
53
]
} |
these results indicate a simultaneous activation of synthesis of trna , rrna as well as of poly ( a ) -containing rna during outgrowth of b. subtilis spores . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
72,
76
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
114,
117
]
} |
the dependence of foot trouble on body weight is evidenced by the fact that overweight women are more prone to develop foot trouble than women with standard weight . | NA | {
"id": "C0497406",
"name": "overweight",
"pos": [
76,
86
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
157,
163
]
} |
the angle of the big toe , in particular , is clearly weight-related , i.e . the risk to develop hallux valgus is greater in overweight women over 55 years of age than it is in standard-weight females . | NA | {
"id": "C0497406",
"name": "overweight",
"pos": [
125,
135
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
186,
192
]
} |
the motor activity of the colon is influenced by many factors , mainly by the central nervous system , the gastrointestinal hormones ( cholecystokinin , gastrin , serotonin , insulin and prostaglandins ) , the diet and the way of life . | NA | {
"id": "C0017182",
"name": "gastrointestinal hormones",
"pos": [
107,
132
]
} | {
"id": "C0008328",
"name": "cholecystokinin",
"pos": [
135,
150
]
} |
the motor activity of the colon is influenced by many factors , mainly by the central nervous system , the gastrointestinal hormones ( cholecystokinin , gastrin , serotonin , insulin and prostaglandins ) , the diet and the way of life . | NA | {
"id": "C0017182",
"name": "gastrointestinal hormones",
"pos": [
107,
132
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
153,
160
]
} |
this examination method was particularly suitable in cholelithiases , in concrements of the choledochus , in diseases of the pancreas above all in different forms of pancreatitis and pancreatic tumours and in abdominal lymphomas . | NA | {
"id": "C0030286",
"name": "diseases of the pancreas",
"pos": [
109,
133
]
} | {
"id": "C0030305",
"name": "pancreatitis",
"pos": [
166,
178
]
} |
associated positivity to various aromatic balsam-like substances ( balsam of peru , turpentine , colophony , wood tar ) has been interpreted as pseudo-cross-allergy . | NA | {
"id": "C0004714",
"name": "balsam",
"pos": [
42,
48
]
} | {
"id": "C0070477",
"name": "balsam of peru",
"pos": [
67,
81
]
} |
the pseudotumorous forms of cystitis , the benign diseases of the adjacent organs , the rare diseases of the urinary bladder as well as the malignomas of extravesical origin are included into the differential diagnosis of tumours of the urinary bladder . | NA | {
"id": "C0010692",
"name": "cystitis",
"pos": [
28,
36
]
} | {
"id": "C0005686",
"name": "the",
"pos": [
233,
236
]
} |
in addition , the eia offers the possibility to detect antibodies belonging to different immunoglobulin classes . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
55,
65
]
} | {
"id": "C0021017",
"name": "immunoglobulin classes",
"pos": [
89,
111
]
} |
full sensitization to picryl chloride is achieved as early as 3 days after a single painting with the hapten . | NA | {
"id": "C0031891",
"name": "picryl chloride",
"pos": [
22,
37
]
} | {
"id": "C0018593",
"name": "hapten",
"pos": [
102,
108
]
} |
thus no impairment was found in the gh-dependent sma levels or the ability of hgh to generate somatomedin , which indicates that the growth retarding effect of cortisol is most likely due to a direct effect on the tissue . | NA | {
"id": "C0021666",
"name": "sma",
"pos": [
49,
52
]
} | {
"id": "C0037657",
"name": "somatomedin",
"pos": [
94,
105
]
} |
to examine whether endogenous angiotensin -- which has been suggested to produce increased vasopressin ( adh ) release and water intake under dehydration , by stimulating the central nervous system -- is derived from the brain or from the circulating blood or from both , the effects of water deprivation for 46 h on immunoreactive angiotensin ii ( aii ) concentrations of plasma , cerebroventricular perfusate and the hypothalamus were studied in conscious and urethane-anaesthetized rats . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
30,
41
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
332,
346
]
} |
proximal myopathy and different types of neuromuscular syndromes are frequently observed in hyperthyroid patients with complicated thyrotoxicosis . | NA | {
"id": "C0020550",
"name": "hyperthyroid",
"pos": [
92,
104
]
} | {
"id": "C0040156",
"name": "thyrotoxicosis",
"pos": [
131,
145
]
} |
a microspectrophotometric study of the dna content of carcinoma-in-situ germ cells in the testes of eight infertile men revealed an aneuploid dna distribution pattern . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
142,
145
]
} |
we conclude that hypersensitivity or tolerance to ergotamine tartrate is not observed in previous ergotamine abusers . | NA | {
"id": "C0086248",
"name": "ergotamine tartrate",
"pos": [
50,
69
]
} | {
"id": "C0014710",
"name": "ergotamine",
"pos": [
98,
108
]
} |
yet other antidepressants such as mianserin are potent antagonists at central alpha 2-receptors , a phenomenon which can even cause activation of brain ne neurons and form a basis for their therapeutic action . beta-receptor activation in the brain is also suggested to participate in the therapeutic effect of several drugs , e.g . mianserin and the putative antidepressant agent salbutamol , a beta 2- receptor agonist . | NA | {
"id": "C1579362",
"name": "other antidepressants",
"pos": [
4,
25
]
} | {
"id": "C0003289",
"name": "antidepressant agent",
"pos": [
360,
380
]
} |
the association between hypertriglyceridaemia ( type iv hyperlipoproteinaemia ) and reduced fibrinolytic activity might possibly be explained by a reduced lipoprotein lipase activity in these individuals . | NA | {
"id": "C0020557",
"name": "hypertriglyceridaemia",
"pos": [
24,
45
]
} | {
"id": "C0020480",
"name": "type iv",
"pos": [
48,
55
]
} |
moreover , thallium-201 imaging at rest is reliable in assessing the extent of coronary disease in hospitalized patients who can not undergo exercise testing because of unstable angina , uncompensated heart failure , poorly controlled arrhythmias or physical limitations . | NA | {
"id": "C0018799",
"name": "the",
"pos": [
65,
68
]
} | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
235,
246
]
} |
seventeen of the 21 patients with known heart disease were symptomatic ( cardiac arrest in 5 , syncope in 5 , dizziness in 7 ) compared with only 6 of the 17 patients without heart disease ( syncope in 3 and dizziness in 3 ) ( p less than 0.01 ) . | NA | {
"id": "C0018790",
"name": "cardiac arrest",
"pos": [
73,
87
]
} | {
"id": "C0018799",
"name": "heart",
"pos": [
175,
180
]
} |
the order of absorbability ( percentage absorption ) of individual sterols from the mixture of oyster sterols was : cholesterol greater than or equal to 26-carbon sterols greater than or equal to dehydrocholesterol greater than 24-methylene cholesterol greater than brassicasterol greater than plant sterols . | NA | {
"id": "C0038323",
"name": "sterols",
"pos": [
67,
74
]
} | {
"id": "C0031866",
"name": "plant sterols",
"pos": [
294,
307
]
} |
these studies suggest that shellfish sterols are poorly absorbed , and , like plant sterols , effectively reduce dietary and/or endogenous cholesterol absorption from the intestine . | NA | {
"id": "C0038323",
"name": "sterols",
"pos": [
37,
44
]
} | {
"id": "C0031866",
"name": "plant sterols",
"pos": [
78,
91
]
} |
the data indicate a unique instance of tubulointerstitial nephritis caused by antibodies to multiple proximal tubule antigens apparently forming immune complexes in situ . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
78,
88
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
145,
161
]
} |
the weight gain of the smokers was 200 g less than that of the controls matched with them for age , parity , place or residence and marital status , but the difference in birth weight and placental weight accounted for about 85 % of the total sample in order to quantify the separate and joint contributions to birth weight of smoking , maternal weight gain , pre-pregnant weight , height and duration of gestation . | NA | {
"id": "C0005612",
"name": "birth weight",
"pos": [
171,
183
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
373,
379
]
} |
it is concluded that : ( 1 ) pepck activity was highest in the amniotic fluid cells of midtrimester pregnancies as compared to those of pregnancies close to term ; | NA | {
"id": "C0032980",
"name": "midtrimester",
"pos": [
87,
99
]
} | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
136,
147
]
} |
norepinephrine , epinephrine , isoproterenol ( all 1:10 ( 5 ) [ w/v ] in concentration ) , or saline was infused intravenously to the fetus , each on five separate occasions . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
0,
14
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
17,
28
]
} |
we treated 16 patients aged 1 1/2 to 11 years with myopic anisometropic amblyopia with contact-lens correction of refractive error and occlusion . | NA | {
"id": "C0027092",
"name": "myopic",
"pos": [
51,
57
]
} | {
"id": "C0034951",
"name": "refractive error",
"pos": [
114,
130
]
} |
also , other retinopathies , maculopathies , retinoblastoma , retrolental fibroplasia , and retinal breaks , holes , and detachments were included . | NA | {
"id": "C0035309",
"name": "retinopathies",
"pos": [
13,
26
]
} | {
"id": "C0035321",
"name": "retinal breaks",
"pos": [
92,
106
]
} |
the differences between cells grown in cs alone and those grown in cs plus fgf were also demonstrated by the growth of subcultured glomerular cells on purified extracellular matrix proteins ( fibronectin , laminin , or type iv collagen ) or purified heparan sulfate . | NA | {
"id": "C0079323",
"name": "extracellular matrix proteins",
"pos": [
160,
189
]
} | {
"id": "C0016055",
"name": "fibronectin",
"pos": [
192,
203
]
} |
the differences between cells grown in cs alone and those grown in cs plus fgf were also demonstrated by the growth of subcultured glomerular cells on purified extracellular matrix proteins ( fibronectin , laminin , or type iv collagen ) or purified heparan sulfate . | NA | {
"id": "C0079323",
"name": "extracellular matrix proteins",
"pos": [
160,
189
]
} | {
"id": "C0022984",
"name": "laminin",
"pos": [
206,
213
]
} |
these observations demonstrate a close link between adipocyte size and plasma iri and suggest that the hyperinsulinemia and peripheral insulin resistance of obesity are more likely due to adipocyte hypertrophy than to increases in total body fat or daily food intake . | NA | {
"id": "C0020459",
"name": "hyperinsulinemia",
"pos": [
103,
119
]
} | {
"id": "C0021655",
"name": "insulin resistance",
"pos": [
135,
153
]
} |
if carbamylcholine ( cch ) or the octapeptide of cholecystokinin-pancreozymin ( cck-op ) was added in the presence of low la3+ concentrations ( 0.1 and 0.3 mmol/l ) to 45ca2+-equilibrated cells , secretagogue-induced 45ca2+ release-reuptake was not inhibited . | NA | {
"id": "C0037167",
"name": "octapeptide",
"pos": [
34,
45
]
} | {
"id": "C0008328",
"name": "pancreozymin",
"pos": [
65,
77
]
} |
prospective controlled trial of cryoprecipitated plasma , plasma protein fraction and serum albumin solution for kidney preservation . | NA | {
"id": "C0071214",
"name": "plasma protein fraction",
"pos": [
58,
81
]
} | {
"id": "C0036773",
"name": "serum albumin",
"pos": [
86,
99
]
} |
the study has revealed no differences in the time elapsed between oral intake and peak blood alcohol concentration and no differential in the height of the peak alcohol concentration for the two groups . | NA | {
"id": "C0684262",
"name": "blood alcohol concentration",
"pos": [
87,
114
]
} | {
"id": "C0001962",
"name": "alcohol",
"pos": [
161,
168
]
} |
simple vitreous haemorrhages usually failed to stimulate a fibroblastic cellular response , whereas vitreous blood clots in eyes with penetrating injuries were frequently invaded by choroidal and/or scleral fibroblasts . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
72,
80
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
207,
218
]
} |
-- the fibroblastic transformation of the endothelial cells is present in man but this may simply represent the migrating form of the cells . | NA | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
7,
19
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
130,
133
]
} |
a recently developed derivative of fentanyl , alfentanil , which showed an extremely short lived activity in pharmacological studies was evaluated in 57 female patients undergoing short gynaecological operations . | NA | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
35,
43
]
} | {
"id": "C0002026",
"name": "alfentanil",
"pos": [
46,
56
]
} |
marked variation was demonstrated in fatty acid occurrence and distribution in the sterol ester , triglyceride , phospholipid , and free fatty acid fractions . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
37,
47
]
} | {
"id": "C0015688",
"name": "free fatty acid",
"pos": [
132,
147
]
} |
dibutyryl cyclic amp and theophylline decreased mannitol flux , suggesting that cyclic amp acts on cl transport by increasing its flow through cellular rather than through paracellular pathways . | NA | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
0,
20
]
} | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
80,
90
]
} |
many authors accept that hbs antigen is implicated , certain tumoral antigens may also play an analagous role . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
29,
36
]
} | {
"id": "C0003335",
"name": "tumoral antigens",
"pos": [
61,
77
]
} |
the identification of factors that affect their in vivo metabolism and excretion , the importance of drug interactions , and the development of methods for estimation of serum and cerebrospinal fluid levels have added both complexity and sophistication to the clinical utilization of the antimicrobial agents . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
56,
66
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
71,
80
]
} |
the number of available antimicrobials has expanded greatly during recent years , although the penicillins , chloramphenicol , and the aminoglycosides remain the mainstay of antibiotic treatment in the majority of cases of bacterial infection of the central nervous system . | NA | {
"id": "C1136254",
"name": "antimicrobials",
"pos": [
24,
38
]
} | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
135,
150
]
} |
the total cellular ck and ck-mm reached highest values around 21 days in both dmd and control cultures , suggesting that dmd cultures do not show delayed myoblast fusion . | NA | {
"id": "C0010287",
"name": "ck",
"pos": [
19,
21
]
} | {
"id": "C0010291",
"name": "ck-mm",
"pos": [
26,
31
]
} |
the surfaces of water distribution mains and suspended particulate matter from drinking water were examined by using scanning electron microscopy to investigate the nature and extent of association of microorganisms with these surfaces . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
16,
21
]
} | {
"id": "C0599638",
"name": "drinking water",
"pos": [
79,
93
]
} |
x-ray energy scans of the pipe surface revealed the presence of five major elemental constituents including silicon , phosphorous , sulfur , calcium , and iron . | NA | {
"id": "C0013879",
"name": "elemental",
"pos": [
75,
84
]
} | {
"id": "C0031705",
"name": "phosphorous",
"pos": [
118,
129
]
} |
substantial quantities of trichothecenes were detected in the refused corn : t-2 toxin ( 30 micrograms/g ) was detected in corn fermented with the f. poae strain ; | NA | {
"id": "C0040952",
"name": "trichothecenes",
"pos": [
26,
40
]
} | {
"id": "C0039185",
"name": "t-2 toxin",
"pos": [
77,
86
]
} |
coliform species recovered from untreated surface water and drinking water by the membrane filter , standard , and modified most-probable-number techniques . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
50,
55
]
} | {
"id": "C0599638",
"name": "drinking water",
"pos": [
60,
74
]
} |
publications relating to cutaneous t-cell lymphomas ( ctcls ) ( principally mycosis fungoides and the sezary syndrome ) , which appeared primarily from 1977 to 1979 , are reviewed . | NA | {
"id": "C0079773",
"name": "cutaneous t-cell lymphomas",
"pos": [
25,
51
]
} | {
"id": "C0036920",
"name": "sezary syndrome",
"pos": [
102,
117
]
} |
the levels of beta 2-microglobulin ( beta 2-m ) in serum and urine of 24 seropositive patients with rheumatoid arthritis ( ra ) treated with regular gold ( sodium aurothiomalate ) injections have been investigated . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
149,
153
]
} | {
"id": "C0018034",
"name": "sodium aurothiomalate",
"pos": [
156,
177
]
} |
one patient suffers from the type of hypophosphatasia that presents in adult life , with fractures that are either spontaneous or the result of minimal trauma . | NA | {
"id": "C0016658",
"name": "fractures",
"pos": [
89,
98
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
152,
158
]
} |
though a few transient arrhythmias were seen , all survivors are in sinus rhythm without evidence of sick sinus syndrome , except 1 patient in whom atrial flutter associated with cardiomyopathy developed 1 year after operation . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
23,
34
]
} | {
"id": "C0004239",
"name": "atrial flutter",
"pos": [
148,
162
]
} |
the results suggest that the simultaneous administration of the two cannabinoids might produce a qualitative stimulus different from that produced by delta 9-thc alone . | NA | {
"id": "C0006864",
"name": "cannabinoids",
"pos": [
68,
80
]
} | {
"id": "C0039663",
"name": "thc",
"pos": [
158,
161
]
} |
in rabbit left atrium and ileum as well as in guinea-pig tracheal chain preparations dose-response curves for isoprenaline , adrenaline , noradrenaline and fenoterol have been determined . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
125,
135
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
138,
151
]
} |
the determination of the pd2-values for the agonists showed a relative high affinity of fenoterol and adrenaline to tracheal beta-adrenoceptors whilst noradrenaline was most affine to atrial beta-adrenoceptors . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
102,
112
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
151,
164
]
} |
the results suggest that both ring c of morphinans and morphines and the furan ring of morphines contribute to binding to the allosteric site ; | NA | {
"id": "C0026548",
"name": "morphinans",
"pos": [
40,
50
]
} | {
"id": "C0026553",
"name": "morphines",
"pos": [
87,
96
]
} |
the periods of maximal pyrophosphate accumulation in yeast coincide with those of the minimal contest of polymeric acid-soluble polyphosphates and intense budding . | NA | {
"id": "C0034320",
"name": "pyrophosphate",
"pos": [
23,
36
]
} | {
"id": "C0032575",
"name": "polyphosphates",
"pos": [
128,
142
]
} |
the ratio of csf albumin/serum albumin ( whose upper limit was 0.65 in the study ) was the best sign of alteration of blood-brain barrier permeability . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
17,
24
]
} | {
"id": "C0036773",
"name": "albumin/serum",
"pos": [
17,
30
]
} |
the ratio of csf albumin/serum albumin and the csf igg level must be compared to the electrophoretic pattern of csf proteins in order to better characterize one aspect of the blood-brain barrier under normal and pathologic conditions of the central nervous system . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
17,
24
]
} | {
"id": "C0036773",
"name": "albumin/serum",
"pos": [
17,
30
]
} |
biological and morphological properties of a virus , isolated from the intestine of infant mice with clinical signs of diarrhea and designated as diarrhea virus of infant mice ( dvim ) , were examined . | NA | {
"id": "C0011991",
"name": "diarrhea",
"pos": [
119,
127
]
} | {
"id": "C0011992",
"name": "diarrhea",
"pos": [
146,
154
]
} |
most of the carbohydrate was removed from influenza virus mrc ii ( h3n2 ) and its purified hemagglutinin ( ha ) on treatment with glycosidases , including alpha-mannosidase , beta-n-acetylglucosaminidase , beta-galactosidase and alpha-fucosidase . | NA | {
"id": "C0017976",
"name": "glycosidases",
"pos": [
130,
142
]
} | {
"id": "C0016787",
"name": "alpha-fucosidase",
"pos": [
229,
245
]
} |
histologically the tumour has a typical cribrose appearance owing to glandular-like and cyst-like cavities among alveolar cell aggregates embedded into intensely developed but poor in cells and somewhat hyalinized stroma . | NA | {
"id": "C0027651",
"name": "tumour",
"pos": [
19,
25
]
} | {
"id": "C0010709",
"name": "cyst",
"pos": [
88,
92
]
} |
the aggregation of cancer in families , possible causes of tissue specificity of hereditary susceptibility to cancer , as well as various kinds of inherited enzyme disorders regarded as the basis of this susceptibility are discussed . | NA | {
"id": "C0314657",
"name": "hereditary susceptibility",
"pos": [
81,
106
]
} | {
"id": "C0012655",
"name": "susceptibility",
"pos": [
204,
218
]
} |
breathy vocal quality was verified in five of nine patients with the ectrodactyly -- ectodermal dysplasia -- cleft palate syndrome , nine of 15 patients with either suspected or confirmed anhidrotic ectodermal dysplasia ( one case of partial expression ) , and one of two siblings with the rapp-hodgkin form of ectodermal dysplasia . | NA | {
"id": "C0013575",
"name": "ectodermal dysplasia",
"pos": [
85,
105
]
} | {
"id": "C0162359",
"name": "anhidrotic ectodermal dysplasia",
"pos": [
188,
219
]
} |
cold-acclimated rats , administered the dipsogenic agents angiotensin i , angiotensin ii , isoproterenol or serotonin , had water intakes not significantly different from control rats . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
58,
69
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
74,
88
]
} |
glucocorticoids and muscle rna : the effect of daily administration of prednisolone to rats on the turnover of gastrocnemius ribosomal rna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
27,
30
]
} | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
125,
138
]
} |
after azosemide , the urine contained more chloride than sodium , the fractional tubular chloride reabsorption was inhibited to a greater degree than that of sodium , the urinary ph fell and the potassium excretion increased . | NA | {
"id": "C0037494",
"name": "chloride",
"pos": [
43,
51
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
89,
97
]
} |
the two aminoglycosides were randomly assigned to hospitalized adult patients with systemic infections , and were administered by i.m . injection or slow i.v . infusion in divided doses generally calculated to deliver either 4-6.5 mg/kg per day of netilmicin , or 3-5 mg/kg per day of gentamicin . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
8,
23
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
285,
295
]
} |
cyclophosphamide , ifosfamide , trofosfamide and two secondary metabolites showed a weak activity ( ed50 between 5 x 10 ( -4 ) mol/l and 5 x 10 ( -5 ) mol/l ) . | NA | {
"id": "C0010583",
"name": "cyclophosphamide",
"pos": [
0,
16
]
} | {
"id": "C0020823",
"name": "ifosfamide",
"pos": [
19,
29
]
} |
[ determination of bumadizone , phenylbutazone and oxyphenbutazone in human plasma by high-performance liquid chromatography ( author 's transl ) ] . | NA | {
"id": "C0031463",
"name": "phenylbutazone",
"pos": [
32,
46
]
} | {
"id": "C0030078",
"name": "oxyphenbutazone",
"pos": [
51,
66
]
} |
the procedure for the determination of phenylbutazone and oxyphenbutazone is based on a microphase extraction and especially suitable for routine analyses because of its simplicity and rapidity . | NA | {
"id": "C0031463",
"name": "phenylbutazone",
"pos": [
39,
53
]
} | {
"id": "C0030078",
"name": "oxyphenbutazone",
"pos": [
58,
73
]
} |
plasma levels of bumadizone , phenylbutazone and oxyphenbutazone were determined over a period of 384 h . | NA | {
"id": "C0031463",
"name": "phenylbutazone",
"pos": [
30,
44
]
} | {
"id": "C0030078",
"name": "oxyphenbutazone",
"pos": [
49,
64
]
} |
a study was made of hyperlipidemia caused by ascorbic acid deficiency and of the effects of cholesterol , dl-ethionine and aflatoxin on plasma lipoprotein fractions of normal and scorbutic guinea pigs . | NA | {
"id": "C0003969",
"name": "ascorbic acid deficiency",
"pos": [
45,
69
]
} | {
"id": "C0036474",
"name": "scorbutic",
"pos": [
179,
188
]
} |
the plasma lipoprotein fractions of scorbutic animals showed a significantly higher level of pre-beta-lipoprotein and a lower level of alpha-lipoprotein . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
11,
22
]
} | {
"id": "C0023825",
"name": "pre-beta-lipoprotein",
"pos": [
93,
113
]
} |
the plasma lipoprotein fractions of scorbutic animals showed a significantly higher level of pre-beta-lipoprotein and a lower level of alpha-lipoprotein . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
11,
22
]
} | {
"id": "C0065058",
"name": "a",
"pos": [
139,
140
]
} |
the effect of cholesterol feeding and estrogen administration on serum lipoproteins and lipoprotein lipid composition was investigated in male rabbits . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
71,
82
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
100,
105
]
} |
the amount of cholesterol , cholesterol ester , triglycerides and phospholipids was determined in each of the lipoprotein fractions . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
14,
25
]
} | {
"id": "C0008387",
"name": "cholesterol ester",
"pos": [
28,
45
]
} |
it was found that treatment of the cholesterol-fed animals with estrogen resulted in an increase of their serum hdl , hdl cholesterol , hdl phospholipids and hdl triglycerides . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
35,
46
]
} | {
"id": "C0023822",
"name": "hdl cholesterol",
"pos": [
118,
133
]
} |
serum lipids and lipoprotein lipids were studied in 53 patients ( 21 males and 32 females ) with xanthelasma palpebrarum and 40 age-matched normal controls ( 20 males and 20 females ) . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
17,
28
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
29,
35
]
} |
the above results raise the possibility that ( a ) high saturated fatty acid diets may promote atherosclerosis not only by inducing hypercholesterolemia but also by injuring the arterial lining , and ( b ) diabetes may promote atherosclerosis not only by inducing hyperlipemia but also by damaging the arterial wall during periods of uncontrolled ketoacidosis . | NA | {
"id": "C0020443",
"name": "hypercholesterolemia",
"pos": [
132,
152
]
} | {
"id": "C0020473",
"name": "hyperlipemia",
"pos": [
264,
276
]
} |
lipid and apoprotein moieties of the plasma lipoproteins of mongolian gerbils ( meriones unguiculatus ) were compared in animals fed semipurified diets containing either coconut oil ( coc ) or safflower oil ( saf ) . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
0,
5
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
44,
56
]
} |
lipoprotein composition and size were not influenced by the type of dietary fat , suggesting that the hypercholesterolemia with saturated fat feeding was due to the circulation of a greater number of lipoprotein particles . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
0,
11
]
} | {
"id": "C0065058",
"name": "a",
"pos": [
213,
214
]
} |
in contrast to the findings in non-immunized rabbits , no significant decrease in hdl-cholesterol was found as a consequence of the bleedings , but a negative correlation ( p less than 0.05 ) between plasma tg and hdl-cholesterol appeared . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
86,
97
]
} | {
"id": "C0023822",
"name": "hdl-cholesterol",
"pos": [
214,
229
]
} |
the hypotension was associated with myocardial ischaemia , cardiac arrhythmia and ventricular fibrillation , and was treated successfully with i.v . calcium chloride given at the onset of hypotension . | NA | {
"id": "C0003811",
"name": "cardiac arrhythmia",
"pos": [
59,
77
]
} | {
"id": "C0042510",
"name": "ventricular fibrillation",
"pos": [
82,
106
]
} |
it is antigenically distinct from human blood-group substances a and b and from heterophile antigens such as forssman , infectious mononucleosis and serum sickness antigens . | NA | {
"id": "C0003333",
"name": "heterophile antigens",
"pos": [
80,
100
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
164,
172
]
} |
this paper describes results on which the points of covalent linkage between the drugs ( carbinolamine carbon atom ) and dna ( n-2 of guanine ) are deduced , as well as corey-pauling-koltun ( cpk ) models for the various drug-dna adducts . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
121,
124
]
} | {
"id": "C0242958",
"name": "drug-dna adducts",
"pos": [
221,
237
]
} |
these tested experimental predictions include ( 1 ) instability of the drug-dna adducts to denaturation of dna , ( 2 ) saturation binding limits , ( 3 ) effect of drug binding on the structure of dna , ( 4 ) lack of unwinding and in vitro strand breakage of closed-circular supercoiled simian virus 40 ( sv-40 ) dna , ( 5 ) sensitivity of the secondary structure of dna to drug binding , ( 6 ) hydrodynamic properties of the drug-dna adducts , ( 7 ) hydrogen bonding of the 9-phenolic proton in anthramycin to dna , ( 8 ) structure-activity relationships , and ( 9 ) biological consequences of dna damage , including cumulative damage and slow excision repair , double-strain breaks in dna in repair-proficient cells , and the selective inhibition of h-strand dna synthesis in mitochondria . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
76,
79
]
} | {
"id": "C0242958",
"name": "drug-dna adducts",
"pos": [
425,
441
]
} |
antibodies against scallop myosin heavy chain and rod fragment cross-reacted to a variable extent with all invertebrate myosins but with none of the vertebrates species tested . | NA | {
"id": "C0027100",
"name": "myosin heavy chain",
"pos": [
27,
45
]
} | {
"id": "C0027096",
"name": "myosins",
"pos": [
120,
127
]
} |
we have developed a semiquantitative in vitro translation assay for the messenger ribonucleic acid ( mrna ) which encodes cystathionase and have tested two pairs of cys- , cystathionase- and cys+ , cystathionase+ cell lines for their intracellular content of this rna . | NA | {
"id": "C0035696",
"name": "messenger ribonucleic acid",
"pos": [
72,
98
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
264,
267
]
} |
the thermodynamics of double-helix formation by ( dg-dc ) 3 have been measured in aqueous solvent mixtures containing 10 mol % methanol , ethanol , 1-propanol , formamide , n , n-dimethylformamide , or urea and 20 mol % ethanol . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
127,
135
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
220,
227
]
} |
with the assumption that the carbon isotope effect on the decarboxylation step is in the usual range ( 1.05 -- 1.07 ) , it is possible to derive relative rates and solvent isotope effects for all steps in the enzyme mechanism . | NA | {
"id": "C0007017",
"name": "carbon isotope",
"pos": [
29,
43
]
} | {
"id": "C0022262",
"name": "isotope",
"pos": [
172,
179
]
} |
the type of binding of cytochrome c to phospholipids observed here implies that there are specific areas on the protein which appear to be different from those involved in its interaction with cytochrome oxidase and other cytochromes . | NA | {
"id": "C1256752",
"name": "type",
"pos": [
4,
8
]
} | {
"id": "C0010798",
"name": "cytochromes",
"pos": [
222,
233
]
} |
the abortive initiation reaction of rna polymerase has been used to prepare adenylyl- ( 3 ' -- 5 ' ) -uridine 5'-phosphate ( papu ) in 74 % yield from amp and utp . | NA | {
"id": "C0041921",
"name": "uridine",
"pos": [
102,
109
]
} | {
"id": "C0042010",
"name": "utp",
"pos": [
159,
162
]
} |
mechanism of lipid-protein interaction in the plasma lipoproteins : identification of a lipid-binding site in apolipoprotein a-ii . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
13,
18
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
53,
65
]
} |
inactivation of phosphoglucose isomerase , when incubated with various modifier concentrations , was found to be pseudo first order with respect to enzyme concentration ( half-life of inactivation 6 h at ph 7.5 ( 30 degrees c ) and 2.0 mum active site concentration ) but showed saturation kinetics for the dependence on inactivator concentration . | NA | {
"id": "C0018517",
"name": "half-life",
"pos": [
171,
180
]
} | {
"id": "C0022702",
"name": "kinetics",
"pos": [
290,
298
]
} |
the sequencing data together with results of amino acid analysis and c-terminal end-group determination indicated that 4k ss was identical with somatostatin-28 ( ss-28 ) isolated from procine upper small intestine and sequenced by pradayrol et al . | NA | {
"id": "C0037659",
"name": "ss",
"pos": [
122,
124
]
} | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
144,
159
]
} |
trypsin cleaved the somatostatin ( ss ) entity less selectively from ovine hypothalamic ss-28 than from rat hypothalamic 12 000-dalton ss-like polypeptide ( 12k ss ) . | NA | {
"id": "C0074854",
"name": "ss-28",
"pos": [
88,
93
]
} | {
"id": "C0037659",
"name": "ss",
"pos": [
161,
163
]
} |
native ovine hypothalamic ss-28 was found to be highly potent in inhibit growth hormone release from cultured rat anterior pituitary cells . | NA | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
73,
87
]
} | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
114,
132
]
} |
the results raised doubts that ovine ss-28 would be an ss precursor and indicated that ss-28 itself may possess regulatory functions . | NA | {
"id": "C0037659",
"name": "ss",
"pos": [
37,
39
]
} | {
"id": "C0074854",
"name": "ss-28",
"pos": [
87,
92
]
} |
for an understanding of the cation selectivity and general binding characteristics of macrotetralide antibiotic nonactin ( na ) with ions of different sizes and charges , the nature of binding of divalent caption , ca2+ , to na and conformation of the na-ca2+ complex have been studied by use of 270-mhz proton nuclear magnetic resonance ( 1h nmr ) and carbon-13 nuclear magnetic resonance ( 13c nmr ) . | NA | {
"id": "C0007447",
"name": "cation",
"pos": [
28,
34
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
133,
137
]
} |
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