text
stringlengths 57
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| relation
stringclasses 125
values | h
dict | t
dict |
|---|---|---|---|
in plasma membrane isolated from el4 cells , no difference in p values for either probe was observed among membranes from unsubstituted , saturated fatty acid substituted or unsaturated fatty acid substituted cells , even when the degree of fatty acid substitution was quite substantial . | NA | {
"id": "C0015690",
"name": "unsaturated fatty acid",
"pos": [
174,
196
]
} | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
241,
251
]
} |
the erythrocytes were subsequently exposed to a peroxide-generating system consisting of xanthine and xanthine oxidase , or h2o2 for 1 h at 37 degrees c . | NA | {
"id": "C0031180",
"name": "peroxide",
"pos": [
48,
56
]
} | {
"id": "C0020281",
"name": "h2o2",
"pos": [
124,
128
]
} |
the permeability coefficients of novikoff hepatoma ascites cell membranes for tritiated water ( 3hho ) and for a homologous series of monohydric alcohols ( methanol through hexanol ) were deduced from linear diffusion coefficients by means of a series-parallel pathway model ( redwood et al . ( 1974 ) j. gen. physiol . 64 , 706-729 ) . | NA | {
"id": "C0001975",
"name": "alcohols",
"pos": [
145,
153
]
} | {
"id": "C0001963",
"name": "methanol",
"pos": [
156,
164
]
} |
no evidence for liposome-mediated cell death could be found in these cell lines when tubercidin 5'-monophosphate was entrapped in either large or small unilamellar liposomes composed of egg phosphatidylcholine/cholesterol ( 2 : 1 ) , bovine brain phosphatidylserine/egg phosphatidylcholine/cholesterol ( 8 : 2 : 5 ) or egg phosphatidylcholine/stearylamine/cholesterol ( 10 : 1 : 5 ) . | NA | {
"id": "C0023828",
"name": "liposome",
"pos": [
16,
24
]
} | {
"id": "C1721091",
"name": "unilamellar liposomes",
"pos": [
152,
173
]
} |
the results indicate that the na+-enzyme at steady-state tends to be accumulated in an enzyme-potassium complex when k+ is added . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
34,
40
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
87,
93
]
} |
a partially purified preparation of human leukocytic pyrogen , however , caused a 70 % increase in leucine incorporation into haptoglobin relative to albumin in the present of the hormone mixture , suggesting that this substance may affect acute-phase protein synthesis . | NA | {
"id": "C0018595",
"name": "haptoglobin",
"pos": [
126,
137
]
} | {
"id": "C0001347",
"name": "acute-phase protein",
"pos": [
240,
259
]
} |
the 'pulse-chase ' approach also allowed a quantitative estimate to be made of the conversion of nuclear poly ( a ) +-rna and poly ( a ) -u+-rna to cytoplasmic poly ( a ) -rna and poly ( a ) -u+-rna . | NA | {
"id": "C0032402",
"name": "u",
"pos": [
6,
7
]
} | {
"id": "C0032400",
"name": "poly ( a",
"pos": [
105,
113
]
} |
this suggests that a greater part ( if not all ) of 5-methylcytosine in mammalian dnas is a product of dna methylases which recognize the ( 5 ' ) -cg- ( 3 ' ) dna sequence . | NA | {
"id": "C0012854",
"name": "dnas",
"pos": [
82,
86
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
161,
162
]
} |
the kinetics of inactivator ( s ) production varied for the different phenols , and the inactivator activity of the incubated mixture of pyrogallol and cu2+ was notably labile . | NA | {
"id": "C0031428",
"name": "phenols",
"pos": [
70,
77
]
} | {
"id": "C0034303",
"name": "pyrogallol",
"pos": [
137,
147
]
} |
the poly ( adp-ribose ) polymerase activity of wild-type mouse l cells and of balb/c-3t3 mouse fibroblasts remained relatively unchanged ( at approx . 400 nmol substrate utilized/mg dna per h ) in actively-growing cells incubated at 34 degrees c or at 38.5 degrees c for at least 72 h . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
95,
106
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
214,
219
]
} |
a similar result was obtained with the following temperature-sensitive cells grown at the permissive temperature ( 34 degrees c ) : ts a1s9 mouse l cells , ts c1 mouse l cells and balb/c-3t3 ts mouse fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
71,
76
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
200,
211
]
} |
after competition between the enzyme-labeled prostaglandin f2alpha and the free prostaglandin f2alpha in their immunoreaction with prostaglandin f2alpha-specific antiserum , the antigen-antibody conjugate was precipitated by the double antibody method , and the activity of precipitated alkaline phosphatase was determined . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
162,
171
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
236,
244
]
} |
the influx of free and esterified cholesterol into various tissues of cholesterol-fed rabbits is calculated from the tissue [ 3h ] cholesterol and [ 14c ] cholesterol content - corrected for radioactivity in contaminating plasma - after a 3 -- 6 h exposure to in vivo-labeled plasma . | NA | {
"id": "C0008387",
"name": "esterified cholesterol",
"pos": [
23,
45
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
155,
166
]
} |
from tissue free and esterified cholesterol radioactivity , one can calculate that 20 -- 70 % of the newly entered esterified cholesterol was hydrolyzed by various tissues and that most tissues esterified less than 10 % of newly entered cholesterol during the experimental period . | NA | {
"id": "C0008387",
"name": "esterified cholesterol",
"pos": [
21,
43
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
237,
248
]
} |
a comparison is presented between the co binding properties of sulphaemoglobin , myoglobin and haemoglobin and a mechanism whereby the co binding parameters of sulphaemoglobin are modified is proposed . | NA | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
67,
78
]
} | {
"id": "C0038731",
"name": "sulphaemoglobin",
"pos": [
160,
175
]
} |
cholera toxin-activated membranes were responsiveness only to epinephrine and gtp , while fluoride-activated membranes responded somewhat to all other agents , and gpp ( nh ) p-activated membranes responded to no other agents . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
78,
81
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
164,
176
]
} |
for chlorophyll monomeres the death of cation-radicals is described by the 2nd order equation and is conditioned by the recombination of ion-radicals of the pigment and acceptor . | NA | {
"id": "C0007447",
"name": "cation",
"pos": [
39,
45
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
137,
140
]
} |
the membrane protein fraction bound to the crystals was composed of the majority of the putatively intrinsic polypeptides , including the amphiphilic protein spiralin , and several extrinsic polypeptides . | NA | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
4,
20
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
150,
157
]
} |
the amount of cholesterol and the percentage of esterified cholesterol were increased in transformed cells . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
14,
25
]
} | {
"id": "C0008387",
"name": "esterified cholesterol",
"pos": [
48,
70
]
} |
their proteins , referred to here as ifp ( intermediate filament proteins ) , comprise keratin desmin , vimentin , glialin and neurofilin . | NA | {
"id": "C0021769",
"name": "intermediate filament",
"pos": [
43,
64
]
} | {
"id": "C0010803",
"name": "keratin",
"pos": [
87,
94
]
} |
their proteins , referred to here as ifp ( intermediate filament proteins ) , comprise keratin desmin , vimentin , glialin and neurofilin . | NA | {
"id": "C0021769",
"name": "intermediate filament",
"pos": [
43,
64
]
} | {
"id": "C0042666",
"name": "vimentin",
"pos": [
104,
112
]
} |
brine shrimp nauplii labeled with tritiated precursors of protein and nucleic acids ( dna and rna ) were fed to light and dark grown hydras . | NA | {
"id": "C0028606",
"name": "nucleic acids",
"pos": [
70,
83
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
86,
89
]
} |
another possible explanation might be that , unlike 5-htp research , tryptophan studies have so far disregarded the patient 's serotonergic status . | NA | {
"id": "C0000578",
"name": "5-htp",
"pos": [
52,
57
]
} | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
69,
79
]
} |
a survey was carried out throughout europe to establish a registry of experimental digestive tumours , including cancers of the oesophagus , stomach , colon , rectum and pancreas , transplantable tumour lines in animal models , and human digestive tumours grafted into nude mice or immunosuppressed animals . | NA | {
"id": "C0027659",
"name": "experimental",
"pos": [
70,
82
]
} | {
"id": "C0027651",
"name": "tumour",
"pos": [
248,
254
]
} |
we used synchrotron radiation to measure the k-edge absorption spectra of the potassium ion in valinomycin-k+ complexes dissolved in ethanol and methanol . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
133,
140
]
} | {
"id": "C0001963",
"name": "methanol",
"pos": [
145,
153
]
} |
it is suggested that the open-field behavior of wistar rats correlates with the brain catecholamine interplay , the main part being played by adrenaline-synthesizing neurons of a1 area , noradrenaline-synthesizing neurons of locus ceruleus and dopamine-synthesizing neurons of n. arcuatus . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
142,
152
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
187,
200
]
} |
the temperature dependence ( td ) of the membrane repolarization process ( rp ) in muscle cells within the range of 10 -- 20 degrees c following preliminary cooling of muscles , the effect of treatment of diaphragmatic muscles ( dm ) with ouabain ( ou ) ( 10 ( -4 ) m ) and administration of 2,4-dinitrophenol ( 2,4-dnp ) ( 1.5 mg/100g ) on rp were studied in experiments on isolated dm of adult ( 7 -- 8-month-old ) and old ( 28 -- 32-month-old ) male white rats . | NA | {
"id": "C0012466",
"name": "dinitrophenol",
"pos": [
296,
309
]
} | {
"id": "C0045511",
"name": "dnp",
"pos": [
316,
319
]
} |
unlike indomethacin , nonachlazin exerts a direct effect on the rate of tyrosin hydroxylase reaction but has no effect on the activity of cyclooxygenase and on synthetase of prostaglandins . | NA | {
"id": "C0020364",
"name": "hydroxylase",
"pos": [
80,
91
]
} | {
"id": "C0033551",
"name": "synthetase",
"pos": [
160,
170
]
} |
motional excitement ( me ) , dopamine ( da ) and homovanillic acid ( hva ) content in the caudate nucleus of rats who were injected with morphine in doses of 2 and 10 mg/kg intraperitoneally after amyzil ( 40 mg/kg ) given via the same route were studied to clarify the character of the action of narcotic analgetics on animals ' behavior and dan metabolism under conditions of imbalance between the cholinergic and dopaminergic neuromediator systems of the striatum , induced by central cholinolytics . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
29,
37
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
416,
428
]
} |
the occurrence of a single-phase circadian rhythm in the content of cortisole , 11-deoxycortisole , 17-hydroxypregnenolone , 17-hydroxyprogesterone , pregnenolone and progesterone in the blood plasma of hamadryas baboons was established by radioimmunoassay with peak levels early in the morning and minimum ones in the evening . | NA | {
"id": "C0376260",
"name": "17-hydroxypregnenolone",
"pos": [
100,
122
]
} | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
150,
162
]
} |
the occurrence of a single-phase circadian rhythm in the content of cortisole , 11-deoxycortisole , 17-hydroxypregnenolone , 17-hydroxyprogesterone , pregnenolone and progesterone in the blood plasma of hamadryas baboons was established by radioimmunoassay with peak levels early in the morning and minimum ones in the evening . | NA | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
125,
147
]
} | {
"id": "C0033308",
"name": "progesterone",
"pos": [
167,
179
]
} |
destruction of kinin was blocked by 8-hydroxyquinoline ( 0.03-0.05 ml of saturated solution per 1 ml of blood ) or by unithiol ( 2,3-dimercaptopropanol-2 mg/ml ) . | NA | {
"id": "C0041738",
"name": "unithiol",
"pos": [
118,
126
]
} | {
"id": "C0012383",
"name": "dimercaptopropanol",
"pos": [
133,
151
]
} |
in this report we have compared the effects of isolated lipoproteins [ very low density lipoproteins ( vldl ) , low density lipoproteins ( ldl ) , and high density lipoproteins ( hdl ) ] and lipoprotein-depleted plasma ( ldp ) on dna synthesis by phytohemagglutinin-stimulated human lymphocytes . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
56,
68
]
} | {
"id": "C0023825",
"name": "vldl",
"pos": [
103,
107
]
} |
the relative potency for the inhibition of lymphocyte proliferation was vldl greater than ldl greater than hdl greater than ldp . | NA | {
"id": "C0023825",
"name": "vldl",
"pos": [
72,
76
]
} | {
"id": "C0023820",
"name": "ldp",
"pos": [
124,
127
]
} |
although the immune regulatory role of plasma lipoproteins is uncertain , we suggest tha vldl and ldl-in may maintain circulating blood lymphocytes in a nonproliferative state via their respective cell receptor mechanisms . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
46,
58
]
} | {
"id": "C0023825",
"name": "vldl",
"pos": [
89,
93
]
} |
peripheral blood mononuclear cells ( pbmc ) from 18 untreated patients with non-hodgkin 's lymphoma ( nhl ) were studied to characterize the cellular mechanisms contributing to impaired in vitro lymphocyte responses after stimulation by the mitogen conconavalin a ( con-a ) . | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
0,
34
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
141,
149
]
} |
however , in 2 older monkeys , ai conversion was not altered by cei although the vascular response to ai was attenuated by both the aii antagonist ( saralasin ) and the antibody to aii ( ab-aii ) . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
149,
158
]
} | {
"id": "C0003009",
"name": "aii",
"pos": [
190,
193
]
} |
in these 2 older animals , renin substrate caused vasoconstriction that was not altered by cei , but was reduced by saralasin and ab-aii . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
116,
125
]
} | {
"id": "C0003009",
"name": "aii",
"pos": [
133,
136
]
} |
1 in cats anaesthetized with pentobarbitone sodium or chloralose , the amino acids , gamma-aminobutyric acid ( gaba ) and glycine , were applied to the ventral surface of the brain through paired perspex rings placed across the medulla . | NA | {
"id": "C0002520",
"name": "amino",
"pos": [
71,
76
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
122,
129
]
} |
anticoagulant activity of dermatan sulphates is unaffected by antiserum specific for antithrombin iii ( at iii ) unless the glycosaminoglycan preparation contains demonstrable heparin . | NA | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
124,
141
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
176,
183
]
} |
in 142 patients who had the presence or absence of gall stones proved by surgery gall stones had been correctly predicted in 84 % of patients with stones and absent in 64 % of those without . | NA | {
"id": "C0008350",
"name": "gall stones",
"pos": [
51,
62
]
} | {
"id": "C0006736",
"name": "stones",
"pos": [
147,
153
]
} |
these results suggest that antibodies directed against other myelin components are responsible for the myelination-inhibition and demyelination produced by anti-central nervous system ( cns ) and anti-myelin antisera in vitro . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
27,
37
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
208,
216
]
} |
in contrast to previous results obtained in pigmented rats , photic stimulation with flashing white light did not alter the release of glycine or any of the other amino acids . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
135,
142
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
163,
174
]
} |
the suppressive effect of histidyl-proline diketopiperazine was antagonized by the enkephalin analogue , d-ala-met-enkephalin , in equimolar concentrations . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
83,
93
]
} | {
"id": "C0014295",
"name": "met-enkephalin",
"pos": [
111,
125
]
} |
in the present study no significant release of axonally transported protein from frog sciatic nerves was detected with more stringent control for non-axonal sources of released protein . | NA | {
"id": "C0007292",
"name": "transported protein",
"pos": [
56,
75
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
177,
184
]
} |
beta-endorphin-induced increases in plasma epinephrine , norepinephrine and dopamine in rats : inhibition of adrenomedullary response by intracerebral somatostatin . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
43,
54
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
57,
71
]
} |
synthetic human beta-endorphin , 7.25 nmol intracisternally , in unanesthetized , freely moving , chronically cannulated , adult male rats increased plasma concentrations of all 3 catecholamines : epinephrine , norepinephrine and dopamine , for the 2 h period studied . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
197,
208
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
211,
225
]
} |
these results permit us to conclude that the hypothalamic areas which inhibit sodium chloride intake predominate over the stimulating areas of the amygdaloid complex in the control of sodium chloride intake . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
85,
93
]
} | {
"id": "C0037494",
"name": "sodium chloride",
"pos": [
184,
199
]
} |
the decreased labeling observed during pulse studies with [ methyl-3h ] choline is due to dilution of the labeled choline into a pool of phosphocholine which is 3.5 times larger in the infected cells . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
72,
79
]
} | {
"id": "C0031716",
"name": "phosphocholine",
"pos": [
137,
151
]
} |
the mg2+-dependent phosphatidate phosphohydrolase activity increased in the microsomal and decreased in the soluble fraction of isolated rat fat cells incubated for short periods with the lipolytic hormones or agents , epinephrine , cyclic amp , theophylline , and dibutyryl cyclic amp . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
233,
243
]
} | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
265,
285
]
} |
the composition of the lipid extracted from the structural glycoproteins is quite distinct from the lipid in the guanidine . hcl extract of cartilage , the lipid of cartilage matrix vesicles , and that of other known lipid membranes . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
23,
28
]
} | {
"id": "C0025249",
"name": "lipid membranes",
"pos": [
217,
232
]
} |
no antigenic relationships have been found between the cartilage structural glycoproteins or cartilage extracts and the plasma lipoproteins ldl , vldl , and lp ( a ) . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
127,
139
]
} | {
"id": "C0065058",
"name": "lp ( a",
"pos": [
157,
163
]
} |
phosphate transport was affected by high luminal sulfate concentrations indicating distinct reabsorptive mechanisms for these two anions . | NA | {
"id": "C0038720",
"name": "sulfate",
"pos": [
49,
56
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
130,
136
]
} |
enhanced distal delivery of sulfate significantly inhibited calcium and magnesium reabsorption in the distal tubule , a site where the sulfate anion is not reabsorbed . | NA | {
"id": "C0038720",
"name": "sulfate",
"pos": [
28,
35
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
143,
148
]
} |
a similar relationship was observed between gfr and bicarbonate reabsorption during ca inhibition in normal dogs ( r equals 0.957 ) as well as in sodium bicarbonate loaded dogs ( r equals 0.867 ) . | NA | {
"id": "C0005367",
"name": "bicarbonate",
"pos": [
52,
63
]
} | {
"id": "C0074722",
"name": "sodium bicarbonate",
"pos": [
146,
164
]
} |
distal tubular blockade with ethacrynic acid and chlorothiazide , performed in normal dogs and in sodium bicarbonate loaded dogs , did not abolish glomerulotubular balance for bicarbonate during ca inhibition . | NA | {
"id": "C0074722",
"name": "sodium bicarbonate",
"pos": [
98,
116
]
} | {
"id": "C0005367",
"name": "bicarbonate",
"pos": [
176,
187
]
} |
in animals treated with reserpine , gaba still produces its normal effects ( reduction of epsp size , synaptic depression , posttetanic potentiation , and increase of facilitation ) , indicating that baclofen does not act directly on the gaba receptor located on the presynaptic terminal . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
36,
40
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
200,
208
]
} |
after 10 weeks the difference in body weight between the sedentary rats ( body weight ( bw ) equals 514.4 plus or minus 76.4 g ) and the exercise rats ( bw equals 389 plus or minus 44 g ) was significant ( p less than 0.05 ) . | NA | {
"id": "C0005911",
"name": "difference",
"pos": [
19,
29
]
} | {
"id": "C0005910",
"name": "bw",
"pos": [
153,
155
]
} |
the difference in body weight between the high fat diet rats ( bw equals 479 plus or minus 80 g , n equals 10 ) and the balanced diet group ( bw equals 424 plus or minus 76 g , n equals 10 ) was also significant ( p less than 0.05 ) . | NA | {
"id": "C0005911",
"name": "difference",
"pos": [
4,
14
]
} | {
"id": "C0005910",
"name": "bw",
"pos": [
142,
144
]
} |
the affinity of pst was , in descending order , towards dopamine ( da ) greater than norepinephrine ( ne ) greater than epinephrine ( e ) ( km ( da ) equals 17.6 microm , km ( ne ) equals 66.6 microm , km ( e ) equal 330 micro m ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
88,
99
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
176,
178
]
} |
the progressive ataxia and epileptic , sometimes myoclonic , seizures in these patients and the dentate nucleus changes in the autopsied patient were consistent with the diagnosis of dyssynergia cerebellaris myoclonica . | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
27,
36
]
} | {
"id": "C0014550",
"name": "myoclonic",
"pos": [
208,
217
]
} |
this study of 93 patients with clearly documented previous optic neuritis was conducted to determine the statistical relationship between these three measures and other clinical diagnostic indices for detection for previous optic nerve disease and the utility of the diagnostic predictors taken individually , and in combination . | NA | {
"id": "C0029134",
"name": "optic",
"pos": [
59,
64
]
} | {
"id": "C0029132",
"name": "optic nerve disease",
"pos": [
224,
243
]
} |
conventional histology , aspiration cytology , and electron microscopy disclosed histiocyte-like cells , fibroblast-like cells , and multinucleated giant cells of both osteoclast-like benign and pleomorphic malignant type , in varying proportions . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
97,
102
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
105,
115
]
} |
sixty-five had acute lymphoblastic leukemia , nine had acute myeloblastic leukemia , nine had malignant lymphoma ( four hodgkin and five non-hodgkin ) , five had chronic myeloid leukemia , four had rhabdomyosarcoma , three had cns tumors , two had neuroblastoma , one had wilms , and four had other malignant tumors . | NA | {
"id": "C0024299",
"name": "malignant lymphoma",
"pos": [
94,
112
]
} | {
"id": "C0024305",
"name": "non-hodgkin",
"pos": [
137,
148
]
} |
this evidence and observations in renal allograft recipients , patients with pemphigus , and patients with other autoimmune disorders point to the frequency of a common background of deranged immune status in patients with ks . | NA | {
"id": "C0030807",
"name": "pemphigus",
"pos": [
77,
86
]
} | {
"id": "C0004364",
"name": "autoimmune disorders",
"pos": [
113,
133
]
} |
hemoptysis was the only presenting symptom in two of the four reported cases and significant bleeding occurred during biopsy in the other two cases . | NA | {
"id": "C0019079",
"name": "hemoptysis",
"pos": [
0,
10
]
} | {
"id": "C0019080",
"name": "bleeding",
"pos": [
93,
101
]
} |
the results of this study , together with the absence of brain lesions in published reports in children receiving high-dose methotrexate but no cranial irradiation , indicate that delayed neurotoxicity is not a major complication of this form of therapy in older children . | NA | {
"id": "C0008059",
"name": "children",
"pos": [
95,
103
]
} | {
"id": "C1455726",
"name": "older children",
"pos": [
257,
271
]
} |
the gyrase-dna complex differs from the nucleosome , however , in that it must possess features necessary for the catalysis of dna chain breakage and the modulation of the dna-enzyme interaction by atp . | NA | {
"id": "C0540193",
"name": "catalysis",
"pos": [
114,
123
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
172,
175
]
} |
we have determined the effect of parental cell concentration at the time of fusion with polyethylene glycol on the frequency of viable somatic hybrids and of polykaryocytes of different multiplicity , between chinese hamster ( line wg3 ) and mouse ( line 3tp ) fibroblasts . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
19,
22
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
261,
272
]
} |
by using antisera against ( a ) apolipoprotein ai ( a major apolipoprotein of hdl ) and ( b ) apolipoprotein e ( an apolipoprotein present in hdlc ) , the binding of hdl at 4 degrees c to indentations of the plasma membrane could be demonstrated . | NA | {
"id": "C0003595",
"name": "apolipoprotein e",
"pos": [
94,
110
]
} | {
"id": "C0003591",
"name": "apolipoprotein",
"pos": [
116,
130
]
} |
these folds of gastric mucosa are located more often in the terminal ileum than in the jejunum and act as the leading part of intussusception : the clinical finding were usually those of subacute obstruction of the small intestine and can occur during several years before an intestinal obstruction leading to surgery : after reduction of the intussusception , intestinal resection must be done . | NA | {
"id": "C0021933",
"name": "intussusception",
"pos": [
126,
141
]
} | {
"id": "C0021843",
"name": "intestinal",
"pos": [
361,
371
]
} |
we conclude that intermittent claudication may be used as a simple model for studies of arteriosclerosis , the arm-ankle systolic pressure gradient being a measure of the degree of arteriosclerosis between heart and ankle . | NA | {
"id": "C0021775",
"name": "intermittent claudication",
"pos": [
17,
42
]
} | {
"id": "C0003850",
"name": "arteriosclerosis",
"pos": [
181,
197
]
} |
elevated serum beta 2 microglobulin correlated with demonstration of rheumatoid factor but not with detection of circulating immune complexes , hepatitis b virus markers or autoantibodies . | NA | {
"id": "C0035448",
"name": "rheumatoid factor",
"pos": [
69,
86
]
} | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
173,
187
]
} |
the presence of this enzyme in amniotic fluid cell cultures , both fibroblastic and mixed cell type , makes possible the prenatal detection of these diseases . | NA | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
67,
79
]
} | {
"id": "C0007634",
"name": "cell type",
"pos": [
90,
99
]
} |
the sensitivity of the assay developed was at 2.2 pg for prostaglandin e and 2pg for prostaglandin f alpha . | NA | {
"id": "C0033554",
"name": "pg",
"pos": [
50,
52
]
} | {
"id": "C0033561",
"name": "prostaglandin",
"pos": [
85,
98
]
} |
dopamine , noradrenaline and adrenaline all had a high affinity for the enzyme , with km values of 3.0 , 5.0 and 2.7 mumol/l respectively . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
11,
24
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
29,
39
]
} |
testicular function was evaluated in forty-one prepubertal patients with male pseudohermaphroditism by determining serum concentrations of progesterone , 17-hydroxyprogesterone , dehydroepiandrosterone , androstenedione , testosterone and dihydrotestosterone before and after stimulation with hcg and , in some instances , acth . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
139,
151
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
154,
176
]
} |
in one patient , a 4-year-old boy , a deficiency of 17,20-desmolase activity was diagnosed based on the coexistence of elevated levels of pregnenolone , 17-hydroxypregnenolone , progesterone and 17-hydroxyprogesterone and low levels of dehydroepiandrosterone and androstenedione . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
178,
190
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
195,
217
]
} |
the effect of long-acting analogue of met-enkephalin ( damme ) and naloxone on gonadotrophin secretion has been investigated in man . | NA | {
"id": "C0014295",
"name": "met-enkephalin",
"pos": [
38,
52
]
} | {
"id": "C0949300",
"name": "damme",
"pos": [
55,
60
]
} |
under 35 % o2 , cell sheets were thicker and there was increased pleomorphism of chondrocyte and fibroblast cell types , with a relative increase of fibroblast components and reduction in chondroblasts and chondrocyte aggregates . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
16,
20
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
149,
159
]
} |
under 35 % o2 , cell sheets were thicker and there was increased pleomorphism of chondrocyte and fibroblast cell types , with a relative increase of fibroblast components and reduction in chondroblasts and chondrocyte aggregates . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
16,
20
]
} | {
"id": "C0225369",
"name": "chondrocyte",
"pos": [
206,
217
]
} |
the effects of long-term administration of ethane-1-hydroxy-1 , 1-diphosphonate on osteoarthrosis and heterotopic ossification in the mouse knee joint . | NA | {
"id": "C0022408",
"name": "osteoarthrosis",
"pos": [
83,
97
]
} | {
"id": "C0022411",
"name": "mouse",
"pos": [
134,
139
]
} |
to ascertain the origin of multinucleated osteoclasts from hematopoietic stem cells , giant lysosomes peculiar to cells of beige mice ( bg bg ) were used as marker cells of that provenance . | NA | {
"id": "C0018956",
"name": "hematopoietic stem",
"pos": [
59,
77
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
164,
169
]
} |
a large proportion of both men and women with moderate trauma fractures had some evidence of preexisting osteoporosis . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
55,
61
]
} | {
"id": "C0016658",
"name": "fractures",
"pos": [
62,
71
]
} |
resorption of cartilage matrix is usually considered to be due to extrinsic proteases , generally thought to be the neutral metalloproteases , including collagenase . | NA | {
"id": "C0030940",
"name": "proteases",
"pos": [
76,
85
]
} | {
"id": "C0025543",
"name": "metalloproteases",
"pos": [
124,
140
]
} |
recently , a radioimmunoassay specific for group i pepsinogens ( pgi ) , one of two immunochemically distinct groups of human pepsinogens or precursor zymogens of pepsin , has been developed . | NA | {
"id": "C0030913",
"name": "pepsinogens",
"pos": [
51,
62
]
} | {
"id": "C0014436",
"name": "zymogens",
"pos": [
151,
159
]
} |
we describe four cases of drownings or near drownings in pails and summarize the literature . | NA | {
"id": "C0013142",
"name": "drownings",
"pos": [
26,
35
]
} | {
"id": "C0027516",
"name": "near drownings",
"pos": [
39,
53
]
} |
serum diazepam and desmethyldiazepam concentrations were measured by electron-capture gas-liquid chromatography in samples drawn up to 72 hr after injection . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
6,
14
]
} | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
19,
36
]
} |
effects of desmethyldiazepam on diazepam kinetics : a study of effects of a metabolite on parent drug disposition . | NA | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
11,
28
]
} | {
"id": "C0012010",
"name": "diazepam",
"pos": [
32,
40
]
} |
the effect of high concentrations of desmethyldiazepam ( dmdz ) , the major metabolite of diazepam ( dz ) , on parent drug kinetics was evaluated in six healthy young subjects who received a single intravenous dose ( 10 mg ) of dz on two occasions . | NA | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
37,
54
]
} | {
"id": "C0012010",
"name": "dz",
"pos": [
228,
230
]
} |
the first dz dose was given in the drug-free control condition and the second after the subject had ingested clorazepate ( czp ) , a precursor of dmdz ( 15 mg daily for 7 days before dz and then during the second dz study ) . | NA | {
"id": "C0011279",
"name": "dmdz",
"pos": [
146,
150
]
} | {
"id": "C0012010",
"name": "dz",
"pos": [
213,
215
]
} |
maximum dmdz concentration after the first dz dose did not exceed 66 ng/ml , whereas mean dmdz levels ( derived from czp ) during the second dz study were 481 +/- 61.5 ng/ml ( se ) for all subjects . | NA | {
"id": "C0011279",
"name": "dmdz",
"pos": [
8,
12
]
} | {
"id": "C0012010",
"name": "dz",
"pos": [
141,
143
]
} |
percent unbound dz was 1.40 +/- 0.25 % when subject plasma was spiked with dz alone and 1.47 +/- 0.21 % when subjects ' plasma was spiked with 500 ng/ml dmdz in addition to dz . | NA | {
"id": "C0011279",
"name": "dmdz",
"pos": [
153,
157
]
} | {
"id": "C0012010",
"name": "dz",
"pos": [
173,
175
]
} |
formation and presence of the active metabolite dmdz had no influence on kinetic behavior of parent dz . | NA | {
"id": "C0011279",
"name": "dmdz",
"pos": [
48,
52
]
} | {
"id": "C0012010",
"name": "dz",
"pos": [
100,
102
]
} |
subsequent camp excretion after ddavp increased inconsistently with no relationship to duration of antidiuresis , indicating that urinary camp is a poor index of antidiuretic hormone action on the distal nephron . | NA | {
"id": "C0003779",
"name": "ddavp",
"pos": [
32,
37
]
} | {
"id": "C0042413",
"name": "antidiuretic hormone",
"pos": [
162,
182
]
} |
the plasma adrenaline and noradrenaline levels in patients with shock due to severe drug intoxication are elevated . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
11,
21
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
26,
39
]
} |
in general , elective surgery in the patient with liver disease should be delayed until consequences of hepatic parenchymal cell dysfunction and portal hypertension are optimally corrected . | NA | {
"id": "C0023895",
"name": "liver disease",
"pos": [
50,
63
]
} | {
"id": "C0020541",
"name": "portal hypertension",
"pos": [
145,
164
]
} |
mean excretory rates of endogenous biliverdin ( bv ) and bilirubin ( br ) in nutria were determined to be 6.0 +/- 1.0 and 0.67 +/- 0.10 microgram/min/kg , respectively . | NA | {
"id": "C0005446",
"name": "biliverdin",
"pos": [
35,
45
]
} | {
"id": "C0005437",
"name": "bilirubin",
"pos": [
57,
66
]
} |
mineral retention was measured during 39 metabolic balance studies in 34 patients with nutritional osteomalacia or late rickets ; | NA | {
"id": "C0029442",
"name": "osteomalacia",
"pos": [
99,
111
]
} | {
"id": "C0035579",
"name": "rickets",
"pos": [
120,
127
]
} |
whether the hla tissue antigens are involved directly in the pathogenesis of cad , act as markers for immune response genes , or serve as markers of other yet undefined genetic factors needs further study . | NA | {
"id": "C0005516",
"name": "markers",
"pos": [
90,
97
]
} | {
"id": "C0017393",
"name": "markers",
"pos": [
138,
145
]
} |
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