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stringclasses 125
values | h
dict | t
dict |
|---|---|---|---|
[ pathogenesis of the polyradiculoneuritic syndrome and its treatment with acth . on the differential diagnosis of diseases simulating poliomyelitis ] . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
43,
51
]
} | {
"id": "C0012634",
"name": "diseases",
"pos": [
115,
123
]
} |
[ effect of clay minerals on the microbiological uptake of carbohydrates and n-containing substances . i. utilization of glucose by the complex soil microflora in sand cultures ] . | NA | {
"id": "C0026162",
"name": "minerals",
"pos": [
17,
25
]
} | {
"id": "C0037098",
"name": "sand",
"pos": [
163,
167
]
} |
[ the influence of thyroid gland function on the pharmacological action of propranolol , adrenaline , noradrenaline and dinitrophenol ] . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
89,
99
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
102,
115
]
} |
[ biogenesis of ergot alkaloids . development and present status of research on alkaloid formation . 3. biogenetic relations between single alkaloids and alkaloid groups ] . | NA | {
"id": "C0014707",
"name": "ergot alkaloids",
"pos": [
16,
31
]
} | {
"id": "C0002062",
"name": "alkaloid",
"pos": [
154,
162
]
} |
further observations on the haemagglutinating protein and on the coagulation by heat of some seminal plasma proteins . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
46,
53
]
} | {
"id": "C0074312",
"name": "seminal plasma proteins",
"pos": [
93,
116
]
} |
[ changes in the activity of chondroitin sulfate-protein degrading enzymes ( glycosaminoglycan hydrolases and peptide hydrolases ) of arterial tissue in old age and in arteriosclerosis ] . | NA | {
"id": "C0020289",
"name": "hydrolases",
"pos": [
95,
105
]
} | {
"id": "C0030940",
"name": "peptide hydrolases",
"pos": [
110,
128
]
} |
[ on a case of late silicosis associated with rheumatoid arthritis : possibility of caplan 's syndrome with small nodes ] . | NA | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
46,
66
]
} | {
"id": "C0006915",
"name": "caplan 's syndrome",
"pos": [
84,
102
]
} |
[ experimental research on the stimulation viral antibody formation under the influence of thymus extracts . ii . the kinetics of adenoviral antibodies in guinea pigs ] . | NA | {
"id": "C0003253",
"name": "viral antibody",
"pos": [
43,
57
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
141,
151
]
} |
adrenaline has a significantly greater effect on the kcl contracture tension than noradrenaline or isoprenaline.4 . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
0,
10
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
82,
95
]
} |
[ detection of immune globulin and autoantibodies in autoimmune diseases , with special reference to sle and hashimoto 's diseases ] . | NA | {
"id": "C0004364",
"name": "autoimmune diseases",
"pos": [
53,
72
]
} | {
"id": "C0024141",
"name": "sle",
"pos": [
101,
104
]
} |
the technique on its own can not be used to identify the immunoglobulin nature of the antibody but is very useful when employed in conjunction with the antiglobulin test using specific antisera and with other methods . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
86,
94
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
185,
193
]
} |
a method is described for the estimation of adrenaline and noradrenaline in a 5 to 10 ml plasma sample.a batch technique of adsorption and elution from alumina is used and the final estimation is carried out using an automated fluorimetric technique based on the trihydroxyindole method . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
44,
54
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
59,
72
]
} |
[ electrophysiologic characteristics of the changes in the condition of the myometrium under the effect of adrenaline and noradrenaline ] . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
107,
117
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
122,
135
]
} |
[ stillbirth , infant mortality and fetal death in 1965 and 1966 ( distribution by region and department ) ] . | NA | {
"id": "C0595939",
"name": "stillbirth",
"pos": [
2,
12
]
} | {
"id": "C0015927",
"name": "fetal death",
"pos": [
36,
47
]
} |
experimental method for producing brain abscesses in dogs with evaluation of the effect of dexamethasone and antibiotic therapy on the pathogenesis of intracerebral abscesses . | NA | {
"id": "C0006105",
"name": "brain abscesses",
"pos": [
34,
49
]
} | {
"id": "C0000833",
"name": "abscesses",
"pos": [
165,
174
]
} |
[ on the determination of biogenic amines in the human skin and its tumors by thin layer chromatographic method ( according to seiler ) . ii . catecholamines ( dopamine , norepinephrine , epinephrine ) and beta-phenylethylamine ] . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
171,
185
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
188,
199
]
} |
[ sanitary study of the spanish drinking water ( iodine content in the water for public consumption ) ] . | NA | {
"id": "C0599638",
"name": "drinking water",
"pos": [
32,
46
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
71,
76
]
} |
[ detection and titration of chloride insecticide residues in surface waters used for drinking water . preliminary note ] . | NA | {
"id": "C0043047",
"name": "waters",
"pos": [
70,
76
]
} | {
"id": "C0599638",
"name": "drinking water",
"pos": [
86,
100
]
} |
[ ruling of the commission des eaux minerales in regard to a request for introduction and sale in france of water from the natural mineral water spring called `` '' adelhaid '' '' , situated at daun ( eifel ) , federal german republic ] . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
108,
113
]
} | {
"id": "C0026157",
"name": "mineral water",
"pos": [
131,
144
]
} |
[ concerning the request for authorization to exploit , after long distance transport , the water of the natural mineral water spring called `` '' clairvic '' '' , situated at volvic ( puy-de-dome ) ] . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
92,
97
]
} | {
"id": "C0026157",
"name": "water",
"pos": [
121,
126
]
} |
central effects of 3,4-dihydroxyphenylalanine and 5-hydroxytryptophane on tetrabenazine pretreated rabbits with special reference to the possible role of catecholamine and serotonin in the brain . | NA | {
"id": "C0013023",
"name": "dihydroxyphenylalanine",
"pos": [
23,
45
]
} | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
154,
167
]
} |
[ biguanides in the treatment of obesity . i. controlled clinical research with placebo , anorectics , phenformin and metformin ] . | NA | {
"id": "C0005382",
"name": "biguanides",
"pos": [
2,
12
]
} | {
"id": "C0031404",
"name": "phenformin",
"pos": [
103,
113
]
} |
[ biguanides in the treatment of obesity . i. controlled clinical research with placebo , anorectics , phenformin and metformin ] . | NA | {
"id": "C0005382",
"name": "biguanides",
"pos": [
2,
12
]
} | {
"id": "C0025598",
"name": "metformin",
"pos": [
118,
127
]
} |
purification and separation of follicle stimulating hormone ( fsh ) and luteinizing hormone ( lh ) from human pituitary gonadotrophins of male urine ( hpg-mu ) . | NA | {
"id": "C0733758",
"name": "follicle stimulating hormone",
"pos": [
31,
59
]
} | {
"id": "C0018066",
"name": "pituitary gonadotrophins",
"pos": [
110,
134
]
} |
purification and separation of follicle stimulating hormone ( fsh ) and luteinizing hormone ( lh ) from human pituitary gonadotrophins of male urine ( hpg-mu ) . | NA | {
"id": "C0023607",
"name": "luteinizing hormone",
"pos": [
72,
91
]
} | {
"id": "C0018066",
"name": "pituitary gonadotrophins",
"pos": [
110,
134
]
} |
effect of hydrocortisone on growth in vitro of fibroblast-like ( fl ) cells derived from rat organs . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
47,
57
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
70,
75
]
} |
isolation and analysis of two types of diester waxes from the skin surface lipids of the rat . | NA | {
"id": "C0043076",
"name": "waxes",
"pos": [
47,
52
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
75,
81
]
} |
[ research on a series of benzofurans . xxx . action of amiodarone on phosphorylating oxidations of rat liver mitochondria ] . | NA | {
"id": "C0005068",
"name": "benzofurans",
"pos": [
26,
37
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
56,
66
]
} |
they were ( a ) ouabain-sensitive mg ( 2+ ) -stimulated atpase , ( b ) k ( + ) -stimulated atpase , ( c ) ( na ( + ) , k ( + ) ) -stimulated atpase and ( d ) na ( + ) -stimulated atpase activities . | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
56,
62
]
} | {
"id": "C0001479",
"name": "na",
"pos": [
158,
160
]
} |
the concentration producing 50 % inhibition was 0.1mum for ouabain-sensitive mg ( 2+ ) -stimulated atpase , 0.2mum for k ( + ) -stimulated atpase , 0.1mum for ( na ( + ) , k ( + ) ) -stimulated atpase and 0.003mum for na ( + ) -stimulated atpase activity . | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
99,
105
]
} | {
"id": "C0001479",
"name": "na",
"pos": [
218,
220
]
} |
it was inhibited by increasing substrate concentration and by urethane , n-butyl carbamate , cyanide , p-benzoquinone or 2,4-dinitrophenol , but not by p-chloromercuribenzoate or menadione . | NA | {
"id": "C0041964",
"name": "urethane",
"pos": [
62,
70
]
} | {
"id": "C0006948",
"name": "carbamate",
"pos": [
81,
90
]
} |
by using amino acid-requiring mutants , this excretion of pyrimidine moiety was shown to be dependent on the presence of both methionine and glycine . | NA | {
"id": "C0002520",
"name": "amino",
"pos": [
9,
14
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
141,
148
]
} |
precipitate formation between concanavalin a and dextran or soluble starch was induced by the incorporation of phosphate groups into the unreactive glucans . | NA | {
"id": "C0038179",
"name": "starch",
"pos": [
68,
74
]
} | {
"id": "C0017696",
"name": "glucans",
"pos": [
148,
155
]
} |
a pharmacological study of the depression of spinal neurones by glycine and related amino acids . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
64,
71
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
84,
95
]
} |
[ determination of human growth hormone in urine by radioimmunologic technic . aspecific factors simulating the presence of the growth hormone ] . | NA | {
"id": "C0169964",
"name": "human growth hormone",
"pos": [
19,
39
]
} | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
128,
142
]
} |
[ influence of the selective inhibition of true cholinesterase and false cholinesterase on muscular development in the chick embryo ] . | NA | {
"id": "C0001044",
"name": "true cholinesterase",
"pos": [
43,
62
]
} | {
"id": "C0008429",
"name": "cholinesterase",
"pos": [
73,
87
]
} |
[ on the question of locally conditioned peculiarities in the metabolism and excretion of steroid hormones in women under the climatic-geographic conditions of the tadzhikistan republic ] . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
62,
72
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
77,
86
]
} |
[ studies on the lipid metabolism of fetal erythroblastosis rh and abo . non-esterified plasma fatty acids and gas chromatographic fractionation of plasma and erythrocyte fatty acids ] . | NA | {
"id": "C0015688",
"name": "non-esterified",
"pos": [
73,
87
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
171,
182
]
} |
by means of potentiometric ph titrations at 25 degrees c and an ionic strength of 1.0 ( kno ( 3 ) ) , the formation of ca ( ii ) -dpa ( 1:1 and 1:2 ) chelates and the interactions of ca ( ii ) -dpa chelate with a mole of each of three typical amino acids viz. , cysteine , alanine , and glycine has been investigated . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
243,
254
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
273,
280
]
} |
by means of potentiometric ph titrations at 25 degrees c and an ionic strength of 1.0 ( kno ( 3 ) ) , the formation of ca ( ii ) -dpa ( 1:1 and 1:2 ) chelates and the interactions of ca ( ii ) -dpa chelate with a mole of each of three typical amino acids viz. , cysteine , alanine , and glycine has been investigated . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
243,
254
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
287,
294
]
} |
changes in the reactivity of human adipose tissue in vitro to epinephrine and norepinephrine during postnatal development . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
62,
73
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
78,
92
]
} |
[ fibroadenomas , phyllode tumors and mammary sarcomas ( apropos of 2 cases of progressive sarcomatous transformation of a clinically and histologically initially benign mammary nodule ] . | NA | {
"id": "C0010701",
"name": "phyllode tumors",
"pos": [
18,
33
]
} | {
"id": "C1261473",
"name": "sarcomas",
"pos": [
46,
54
]
} |
[ catamnestic studies in early childhood with reference to the existing relationship between febril convulsions and epilepsy ] . | NA | {
"id": "C0036572",
"name": "convulsions",
"pos": [
100,
111
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
116,
124
]
} |
biochemistry of cerebral tumours : sodium , potassium , calcium , phosphorus , magnesium , copper and sulphur contents of astrocytomata , medulloblastomata and glioblastomata multiforme . | NA | {
"id": "C0004114",
"name": "astrocytomata",
"pos": [
122,
135
]
} | {
"id": "C0017636",
"name": "glioblastomata",
"pos": [
160,
174
]
} |
acid extracts were assayed for reduced glutathione ( gsh ) and oxidized glutathione ( gssg ) , by the sensitive enzymatic procedure of tietze . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
53,
56
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
86,
90
]
} |
the optimal concentrations eliciting an efficient rate of enzyme secretion were 1 microm for carbamylcholine or acetylcholine , and 5 nm and 20 nm for cck-pz octapeptide and cck-pz , respectively . | NA | {
"id": "C0037167",
"name": "cck-pz octapeptide",
"pos": [
151,
169
]
} | {
"id": "C0008328",
"name": "cck-pz",
"pos": [
174,
180
]
} |
the inhibition of enzyme secretion was reversible since restoration of efficient enzyme secretion occurred after removal of carbamylcholine ( 1 mm ) by washing , followed by addition of an optimal concentration of cck-pz octapeptide . | NA | {
"id": "C0037167",
"name": "cck-pz octapeptide",
"pos": [
214,
232
]
} | {
"id": "C0008328",
"name": "cck-pz",
"pos": [
214,
220
]
} |
sequential fixation in aldehyde followed by ethanol or methanol provided the best conditions for ultrastructural indirect immunocytochemical studies . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
44,
51
]
} | {
"id": "C0001963",
"name": "methanol",
"pos": [
55,
63
]
} |
the chemical activities of the viking biology experiments and the arguments for the presence of superoxides , peroxides , gamma-fe2o3 and carbon suboxide polymer in the martian soil . | NA | {
"id": "C0038836",
"name": "superoxides",
"pos": [
96,
107
]
} | {
"id": "C0031180",
"name": "peroxides",
"pos": [
110,
119
]
} |
follicular-cell tumors of the thyroid ( carcinomas , cystadenocarcinomas , adenomas , cystadenomas , and papillary cystadenomas ) occurred at statistically significant incidences ( p < /= 0.005 ) in low- and high-dose groups of male rats ( controls 0/53 , low-dose 7/40 , high-dose 6/40 ) ; | NA | {
"id": "C0001430",
"name": "adenomas",
"pos": [
75,
83
]
} | {
"id": "C0010633",
"name": "cystadenomas",
"pos": [
115,
127
]
} |
in high dose male and female rats groups , the proportion of animals having one or more of the following malignant follicular-cell thyroid tumors : papillary adenocarcinomas , follicular-cell carcinomas , papillary cystadenocarcinomas , or adenocarcinomas nos , was significantly greater than the proportion in corresponding control groups . | NA | {
"id": "C0206682",
"name": "follicular",
"pos": [
115,
125
]
} | {
"id": "C0001418",
"name": "adenocarcinomas",
"pos": [
240,
255
]
} |
diagnoses included transposition of the great arteries ( 4 ) , tetralogy of fallot ( 4 ) , pulmonary arterial atresia ( 2 ) , and taussig-bing syndrome ( 1 ) . | NA | {
"id": "C0040761",
"name": "transposition of",
"pos": [
19,
35
]
} | {
"id": "C0013069",
"name": "taussig-bing syndrome",
"pos": [
130,
151
]
} |
since coronary revascularization surgery is most frequently performed to relieve chest pain , there are few reports evaluating the results of coronary artery bypass surgery in patients with minimal or no angina pectoris but with anatomically severe disease . | NA | {
"id": "C0008031",
"name": "chest pain",
"pos": [
81,
91
]
} | {
"id": "C0002962",
"name": "angina pectoris",
"pos": [
204,
219
]
} |
in contrast , the four study dogs placed on tcpbp experienced an abrupt fall of the cci to 30 % ( p < 0.03 ) , severe ischemia , and infarction in each ; | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
118,
126
]
} | {
"id": "C0021308",
"name": "infarction",
"pos": [
133,
143
]
} |
detection of the latter in the cultures during growth gives rise to the suggestion that collagen-producing cells ( true fibroblasts ) may be formed in vitro . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
107,
112
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
120,
131
]
} |
since these cells contain neutral fat bodies , the possibility of a reversible conversion to fat cells has to be assumed and ( e ) fibroblasts , cells which synthesize the substance of the extracellular space . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
131,
142
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
145,
150
]
} |
we recommend vigorous continual respiratory therapy for for infants and small children and intracardiac repair in older children since repair in infancy does not relieve respiratory symptoms . | NA | {
"id": "C0008059",
"name": "children",
"pos": [
78,
86
]
} | {
"id": "C1455726",
"name": "older children",
"pos": [
114,
128
]
} |
patients with mitral valve prolapse ( mvp ) frequently experience chest pain which may , expecially in older subjects and males , be difficult to differentiate from angina pectoris . | NA | {
"id": "C0008031",
"name": "chest pain",
"pos": [
66,
76
]
} | {
"id": "C0002962",
"name": "angina pectoris",
"pos": [
165,
180
]
} |
vasoactive intestinal peptide and impure cholecystokinin-pancreozymin ( but not the 99 % pure preparation or pure cholecystokinin octapeptide ) were potent stimuli , but pentagastrin , glucagon , secretin , and gastric inhibitory peptide were impotent . | NA | {
"id": "C0008328",
"name": "cholecystokinin-pancreozymin",
"pos": [
41,
69
]
} | {
"id": "C0037167",
"name": "cholecystokinin octapeptide",
"pos": [
114,
141
]
} |
nucleic acid contents , dna specific activity , villous height , crypt depth , and luminal circumference were greatest 1 week after resection . | NA | {
"id": "C0028606",
"name": "nucleic acid",
"pos": [
0,
12
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
24,
27
]
} |
a study of serum estradiol , progesterone , 17alpha-hydroxy-progesterone , testosterone , dihydrotestosterone , dehydroepiandrosterone ( dha ) , delta4-androstenedione ( delta4-a ) , fsh , and lh was carried out in one of three sisters having polycystic ovarian disease for a period of 18 days before wedge resection , at the time of surgery , and for 24 days following wedge resection . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
29,
41
]
} | {
"id": "C0020387",
"name": "17alpha-hydroxy-progesterone",
"pos": [
44,
72
]
} |
taking the vpb reproducibility for the group as a whole , the proportion of subjects having different frequency or kinds of ectopic beats is reasonably stable for the different test occasions . | NA | {
"id": "C0151636",
"name": "vpb",
"pos": [
11,
14
]
} | {
"id": "C0340464",
"name": "ectopic beats",
"pos": [
124,
137
]
} |
the oxidation step produces cholest-4-en-3-one and hydrochloride peroxidesterase hydrolyzes cholesterol esters and cholesterol in direct proportion to the amount of cholesterol present . | NA | {
"id": "C0008387",
"name": "cholesterol esters",
"pos": [
92,
110
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
165,
176
]
} |
under these nonequilibrium conditions , 26 % of the 125i-labeled angiotensin i was bound at zero dose of unlabeled angiotensin , as compared to 57 % at equilibrium after 18 h at 4 degrees c . | NA | {
"id": "C0003006",
"name": "angiotensin i",
"pos": [
65,
78
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
115,
126
]
} |
the percentage of alpha-lipoprotein cholesterol ( mean +/- sd : 38.6 +/- 5.0 ) in children further confirmed the earlier observations that cholesterol derived from alpha-lipoprotein in children constitutes a relatively greater part of the serum total cholesterol than is true of adults . | NA | {
"id": "C0023822",
"name": "alpha-lipoprotein cholesterol",
"pos": [
18,
47
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
251,
262
]
} |
[ 1-14c ] acetyl-coa is used , and labeled acetylcarnitine is measured with a sensitivity of less than 1 to 50 nmol of l-carnitine per 50-microliter sample . | NA | {
"id": "C0001040",
"name": "acetylcarnitine",
"pos": [
43,
58
]
} | {
"id": "C0007258",
"name": "carnitine",
"pos": [
121,
130
]
} |
we describe a homogeneous enzyme immunoassay for measurement of cannabinoid metabolites , as well as delta9-tetrahydrocannabinol ( i ) in urine . | NA | {
"id": "C0006864",
"name": "cannabinoid",
"pos": [
64,
75
]
} | {
"id": "C0039663",
"name": "tetrahydrocannabinol",
"pos": [
108,
128
]
} |
assay of the purified alpha-l-fucosidase showed only trace amounts of contaminating glycosidases present , with beta-galactosidase being the largest contamnant ( 0.5 % by activity ) . | NA | {
"id": "C0016787",
"name": "alpha-l-fucosidase",
"pos": [
22,
40
]
} | {
"id": "C0017976",
"name": "glycosidases",
"pos": [
84,
96
]
} |
three of these could be identified as the characteristic lipoprotein of cholestasis , lp-x , as an enlarged and modified hdl and as a lipoprotein of density 1.055 g/ml intermediate in size between ldl and vldl . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
57,
68
]
} | {
"id": "C0065058",
"name": "a lipoprotein",
"pos": [
132,
145
]
} |
normal fibroblasts and amniotic fluid cells , and cells from patients with mucopolysaccharidosis type i and ii , were cultured in the presence of 35so4 . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
7,
18
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
50,
55
]
} |
a new aminoglycoside antibiotic , netilmicin , was tested against 306 clinical isolates from ill children and compared with sisomicin and gentamicin . | NA | {
"id": "C0027780",
"name": "netilmicin",
"pos": [
34,
44
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
124,
133
]
} |
a new aminoglycoside antibiotic , netilmicin , was tested against 306 clinical isolates from ill children and compared with sisomicin and gentamicin . | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
124,
133
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
138,
148
]
} |
activity against enterobacteriaceae was similar to that of gentamicin but less than that of sisomicin . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
59,
69
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
92,
101
]
} |
the narcotic cueing activity of sufentanil , fentanyl , morphine and met-enkephalin was studied upon their injection into the lateral brain ventricle of the rat . | NA | {
"id": "C0143993",
"name": "sufentanil",
"pos": [
32,
42
]
} | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
45,
53
]
} |
dantrolene irreversibly decreased the response of the vas deferens to epinephrine , norepinephrine , acetylcholine and electrical stimulation . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
70,
81
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
84,
98
]
} |
in this report we present details of the mechanisms for biological methylation of certain metals and metalloids with special emphasis on those elements that are widely dispersed in the biosphere . | NA | {
"id": "C0439879",
"name": "metalloids",
"pos": [
101,
111
]
} | {
"id": "C0013879",
"name": "elements",
"pos": [
143,
151
]
} |
on the basis of the results obtained , the substances can be ranked in the following order of potency ( percent inhibition of surface epithelial proliferation ) : acetylsalicylic acid ( 7.9 % ) , phenylbutazone ( 12.5 % ) , bufexamac ( 16.4 % ) , bendazac ( 16.6 % ) , oxyphenbutazone ( 19.5 % ) , indomethacin ( 20.0 % ) , hydrocortisone ( 20.6 % ) and fluocinolone acetonide ( 32.0 % ) . | NA | {
"id": "C0031463",
"name": "phenylbutazone",
"pos": [
196,
210
]
} | {
"id": "C0030078",
"name": "oxyphenbutazone",
"pos": [
269,
284
]
} |
peaks for progesterone , estrogens and dehydroepiandrosterone were recorded at 2 h , and that of 20alpha-dihydroprogesterone 6 h after hcg injection . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
10,
22
]
} | {
"id": "C0012311",
"name": "dihydroprogesterone",
"pos": [
105,
124
]
} |
the mg2+ requirement of a morphological mutant of bacillus subtlis , rodb strain 104 was highly temperature sensitive in the presence of halide or nitrate anions . | NA | {
"id": "C0028125",
"name": "nitrate",
"pos": [
147,
154
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
155,
161
]
} |
it was found that the matrix protein was extracted from the peptidoglycan of a mutant strain ( lpo ) that lacks another major membrane protein , the lipoprotein , at a lower nacl concentration than was the matrix protein of the wild-type cell ( lpo+ ) . | NA | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
126,
142
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
213,
220
]
} |
examination of amino acid composition showed that acidic amino acids were in high excess over basic amino acids . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
15,
25
]
} | {
"id": "C0815040",
"name": "acidic",
"pos": [
50,
56
]
} |
examination of amino acid composition showed that acidic amino acids were in high excess over basic amino acids . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
15,
25
]
} | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
94,
111
]
} |
these results are consistent with the interpretation that the binding of these proteins increases the stacking of specific single-stranded bases in 5 s rna and aligns them in helical arrays , resulting in a conformation which facilitates base-pairing with nucleotide segment ( s ) of the ribosomal 23 s rna or the transfer rna ( or both ) . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
152,
155
]
} | {
"id": "C0035711",
"name": "transfer rna",
"pos": [
314,
326
]
} |
both the enzymically active form and the isomer having the opposite configuration at carbon 6 inhibited the influx of enzymically synthesized ( + ) -5-methyltetrahydrofolate , methotrexate , and aminopterin . | NA | {
"id": "C0025677",
"name": "methotrexate",
"pos": [
176,
188
]
} | {
"id": "C0002583",
"name": "aminopterin",
"pos": [
195,
206
]
} |
formate-induced inactivation of pig heart mitochondrial aspartate aminotransferase by beta-chloro-l-alanine resulted in the modification of the epsilon-amino group of the lysyl residue which is involved in the formation of an aldimine bond with 4-formyl group of the coenzyme , pyridoxal 5'-phosphate . | NA | {
"id": "C0009235",
"name": "coenzyme",
"pos": [
267,
275
]
} | {
"id": "C0034266",
"name": "pyridoxal 5",
"pos": [
278,
289
]
} |
this suggests that the anion is directly attached to the metal ion in the protein . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
23,
28
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
63,
66
]
} |
homogeneous cgmp-dependent protein kinase catalyzes the rapid incorporation of phosphate , specifically into the inhibitory subunit of purified cardiac troponin with a maximal incorporation of 1 mol of phosphate/mol of troponin . | NA | {
"id": "C0077401",
"name": "inhibitory subunit",
"pos": [
113,
131
]
} | {
"id": "C0041199",
"name": "troponin",
"pos": [
219,
227
]
} |
comparisons with other known sequences indicate that in eukaryotes 5.8 s rrna is more highly conserved than 5 s rna species . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
73,
77
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
112,
115
]
} |
although the purified spectrin-actin did not have a significant atpase of its own , it stimulated the ca2+ , mg2+-atpase of the smooth membrane significantly , suggesting a cooperative interaction between these two fractions . | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
64,
70
]
} | {
"id": "C0001477",
"name": "mg2",
"pos": [
109,
112
]
} |
ultrastructural examination revealed that the cells were morphologically intact , and two distinct types of adrenal medullary cells were identified , on the basis of the morphology of their electron-dense vesicles , as ( a ) adrenaline-containing and ( b ) noradrenaline-containing cells . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
225,
235
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
257,
270
]
} |
a marked increase in alphaa-chains and several beta-crystallin polypeptides accompanies the transition from epithelial to fiberlike lens cells while synthesis of the non-crystallin proteins diminishes significantly . | NA | {
"id": "C0005203",
"name": "beta-crystallin",
"pos": [
47,
62
]
} | {
"id": "C0010422",
"name": "crystallin",
"pos": [
170,
180
]
} |
conversion to cyclic amp sensitivity is detectable after 30 hours growth in medium containing 2 % dmso , and either 0.5 mm 8-br-cyclic amp or 5 nm cholera toxin . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
14,
24
]
} | {
"id": "C0000661",
"name": "8-br-cyclic amp",
"pos": [
123,
138
]
} |
the reverse transformation reaction of chinese hamster ovary cells from compact , epithelial-like , randomly growing , heavily knobbed , lectin reactive cells into stretched , tighly adherent , smooth-surfaced , lectin resistant , fibroblast-like cells normally elicited by dibutyryl camp can be produced to its complete extent by n6-monobutyryl camp or 8-bromo-camp , o2'-monobutyryl camp is ineffective as is camp itself in the absence of an inhibitor of phosphodiesterase activity . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
61,
66
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
231,
241
]
} |
putrescine levels return to normal between 10 and 24 hours after the operation , whereas the increased spermidine level is maintained . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
0,
10
]
} | {
"id": "C0037871",
"name": "level",
"pos": [
114,
119
]
} |
isozyme patterns of enzymes in this line such as lactate dehydrogenase , glucose 6-phosphate dehydrogenase and esterase were of human type . | NA | {
"id": "C0022173",
"name": "isozyme",
"pos": [
0,
7
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
20,
27
]
} |
significantly ( p= < 0.05 ) lower than normal mean cytotoxic indices against lymphocyte targets were seen with effector cells from 10 patients with x-linked agammaglobulinemia ( 3.7+/-4.33 ) , in 10 with common variable agammaglobulinemia ( 16.05+/-7.74 ) , in 3 with immunodeficiency with hyper igm ( 18.41+/-4.88 ) , and in 2 with severe combined immunodeficiency ( 3.94+/-0.3 ) . | NA | {
"id": "C0009447",
"name": "common variable agammaglobulinemia",
"pos": [
204,
238
]
} | {
"id": "C0021051",
"name": "immunodeficiency",
"pos": [
349,
365
]
} |
when patients were consuming unrestricted diets , c apoproteins accounted for 19-49 % of the protein in lipoproteins of d < 1.006 g/ml . | NA | {
"id": "C0003601",
"name": "apoproteins",
"pos": [
52,
63
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
108,
115
]
} |
ingestion of low-fat , high-carbohydrate diets reduced the vldl-c-apoprotein content in all tangier patients ( mean = 17 % of vldl protein vs. 43 % in controls ) . | NA | {
"id": "C0003601",
"name": "apoprotein",
"pos": [
66,
76
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
131,
138
]
} |
to test the hypothesis that in both the liver and renal cortex of the fructose-loaded rat , severity of depletion of inorganic phosphate ( p ( i ) ) , and not the magnitude of accumulation of fructose-1-phosphate ( f-1-p ) , determines the severity of the dose-dependent reduction of atp , we intraperitoneally injected fed rats with fructose , 20 and 40 mumol/g , alone , and at the higher load , in combination with ( a ) sodium phosphate , 20 mumol/g , administered shortly beforehand or subsequently or , ( b ) adenosine , 2 mumol/g , administered beforehand . | NA | {
"id": "C0031603",
"name": "inorganic phosphate",
"pos": [
117,
136
]
} | {
"id": "C0074757",
"name": "sodium phosphate",
"pos": [
424,
440
]
} |
whole lymph had no significant effect on hmg-coa reductase activity in fibroblasts from a patient with homozygous familial hypercholesterolemia , whose cells lack ldl receptors . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
71,
82
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
152,
157
]
} |
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