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stringlengths 57
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stringclasses 125
values | h
dict | t
dict |
|---|---|---|---|
the diabetic patients with occlusive arterial disease had a longer duration of diabetes mellitus and a higher rate of other diabetic complications than those without arterial disease . | NA | {
"id": "C0011849",
"name": "diabetes mellitus",
"pos": [
79,
96
]
} | {
"id": "C0342257",
"name": "diabetic complications",
"pos": [
124,
146
]
} |
lipid and lipoprotein findings are described in a group of 707 persons consisting of normal control subjects , patients with clinical peripheral occlusive arterial disease , patients with diabetes and no occlusive arterial disease , and diabetic patients with occlusive arterial disease . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
0,
5
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
10,
21
]
} |
a few hours after admission lesions characteristic of gas gangrene appeared in the right upper limb without prior trauma , and a clostridial infection was suspected . | NA | {
"id": "C0017105",
"name": "gas gangrene",
"pos": [
54,
66
]
} | {
"id": "C0009062",
"name": "clostridial infection",
"pos": [
129,
150
]
} |
the percentage fall in serum levels of desmethyldiazepam in patients who experienced withdrawal symptoms after stopping diazepam was significantly greater in patients with no withdrawal symptoms . | NA | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
39,
56
]
} | {
"id": "C0012010",
"name": "diazepam",
"pos": [
120,
128
]
} |
our results emphasize the remarkable predominance of ebv-iga antibodies to viral capsid antigen ( vca ) and early antigen ( ea ) in npc patients and prove the value of the test for the initial diagnosis of the disease . | NA | {
"id": "C0003342",
"name": "viral",
"pos": [
75,
80
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
114,
121
]
} |
short chain fatty acids increased significantly with age in e. floccosum whereas these fatty acids represented a minor fraction of the total fatty acids in m. cookie and t. mentagrophytes . | NA | {
"id": "C0015691",
"name": "short chain fatty acids",
"pos": [
0,
23
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
141,
152
]
} |
the fatty acid compositions of the ce , ffa , triacylglycerides and glyceryl ether diesters ( gede ) were determined and oleic acid ( 18:1 ) was found to be the major fatty acid . | NA | {
"id": "C0015688",
"name": "ffa",
"pos": [
40,
43
]
} | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
167,
177
]
} |
the alkyl group composition of the gede consisted essentially of 16:0 and 18:0 and 18:1 carbon atoms in both types of ethers . | NA | {
"id": "C0017886",
"name": "gede",
"pos": [
35,
39
]
} | {
"id": "C0014996",
"name": "ethers",
"pos": [
118,
124
]
} |
in attempting to provide a practical classification of cutaneous mycobacteriosis which includes infection by nontuberculous mycobacteria , we propose the following grouping , which uses simple terms , avoids confusing nomenclature , and incorporates pathophysiologic descriptions and prognostic information : 1 ) mycobacteriosis caused by inoculation from an exogenous source . | NA | {
"id": "C0026919",
"name": "infection",
"pos": [
96,
105
]
} | {
"id": "C0026918",
"name": "mycobacteriosis",
"pos": [
313,
328
]
} |
rrna comprises about 25 % of the total rna synthesized in this system under optimal conditions and is stimulated by a crude protein fraction prepared from e. coli cell extracts . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
0,
4
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
39,
42
]
} |
however , the percentage of sugar phosphates , phosphoenolpyruvate and organic acids ( carbohydrates at the stage of exponential growth ) in these products increased in the presence of np ( exposition for 20 min ) . | NA | {
"id": "C0038655",
"name": "sugar phosphates",
"pos": [
28,
44
]
} | {
"id": "C0007004",
"name": "carbohydrates",
"pos": [
87,
100
]
} |
the fraction of neutral lipids was represented mainly by free fatty acids ( about 5 % ) , tri- and diglycerides ( in trace amounts ) , and two nonidentified classes , apparently , hydrocarbons and waxes . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
24,
30
]
} | {
"id": "C0043076",
"name": "waxes",
"pos": [
197,
202
]
} |
in contrast , the labelling of total nuclear proteins and of total histones continues at an unreduced level for many hours . | NA | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
37,
53
]
} | {
"id": "C0019652",
"name": "histones",
"pos": [
67,
75
]
} |
yet deviant behavior in autosomal chromosome aberrations , especially the down syndrome , on account of their severity and considerable reduction of intelligence of those affected , are far less important to the public than the gonosomal aberrations : the klinefelter syndrome ( xxy ) , the xyy syndrome , gonadal dysgenesis ( turner 's syndrome , xo ) . | NA | {
"id": "C0036868",
"name": "gonosomal aberrations",
"pos": [
228,
249
]
} | {
"id": "C3266843",
"name": "xyy syndrome",
"pos": [
291,
303
]
} |
yet deviant behavior in autosomal chromosome aberrations , especially the down syndrome , on account of their severity and considerable reduction of intelligence of those affected , are far less important to the public than the gonosomal aberrations : the klinefelter syndrome ( xxy ) , the xyy syndrome , gonadal dysgenesis ( turner 's syndrome , xo ) . | NA | {
"id": "C0018051",
"name": "gonadal",
"pos": [
306,
313
]
} | {
"id": "C0041408",
"name": "turner 's syndrome",
"pos": [
327,
345
]
} |
induction of dna single-strand breaks by t2 toxin , a trichothecene metabolite of fusarium : effect on lymphoid organs and liver . | NA | {
"id": "C0039185",
"name": "t2 toxin",
"pos": [
41,
49
]
} | {
"id": "C0040952",
"name": "trichothecene",
"pos": [
54,
67
]
} |
t2 toxin , a trichothecene metabolite produced by fusarium species , contaminates cereals harvested and stored under damp and cold conditions . | NA | {
"id": "C0039185",
"name": "t2 toxin",
"pos": [
0,
8
]
} | {
"id": "C0040952",
"name": "trichothecene",
"pos": [
13,
26
]
} |
combinations of 3 progestins , ethynodiol diacetate , norethynodrel and norgestrel , and 2 oestrogens , ethinyloestradiol and mestranol , were fed to larval oregon-r fruit flies . | NA | {
"id": "C0015011",
"name": "ethinyloestradiol",
"pos": [
104,
121
]
} | {
"id": "C0025506",
"name": "mestranol",
"pos": [
126,
135
]
} |
sera harvested at necropsy from guinea pigs fed penitrem a and control guinea pigs did not differ significantly in mean values of two liver enzymes ( ornithine carbamoyltransferase and sorbitol dehydrogenase ) , complement , total protein , and differential proteins ( albumin ; alpha 1 , alpha 2 , beta , and gamma globulins ) . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
258,
266
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
269,
276
]
} |
heroin hydrochloride is approximately twice as potent as morphine sulfate , and acts slightly faster but for a shorter duration than morphine . | NA | {
"id": "C0066814",
"name": "morphine sulfate",
"pos": [
57,
73
]
} | {
"id": "C0026549",
"name": "morphine",
"pos": [
133,
141
]
} |
the tumour promoter 12-o-tetradecanoyl-phorbol-13-acetate ( tpa ) and structurally related phorbol esters effect changes in avian and mammalian cell cultures that mimic transformation by oncogenic viruses or chemical carcinogens and the inhibition or induction of various types of differentiation ( for review see refs 1 -- 3 ) . | NA | {
"id": "C0039654",
"name": "12-o-tetradecanoyl-phorbol-13-acetate",
"pos": [
20,
57
]
} | {
"id": "C0031586",
"name": "phorbol esters",
"pos": [
91,
105
]
} |
it has the direct function of catalysing pairing of single-stranded dna to a homologous region in duplex dna , a reaction thought to be fundamental to genetic recombination . | NA | {
"id": "C0012935",
"name": "single-stranded",
"pos": [
52,
67
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
105,
108
]
} |
these and previous results indicate that the heavy ( h ) strand sequences coding for the rrna , poly ( a ) -containing rna and trna species form a continuum extending over almost the entire length of this strand . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
89,
93
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
128,
131
]
} |
treatments have included the administration of plasmin , other less specific proteolytic enzymes , the indirect plasminogen activator , streptokinase , and the direct activators , urokinase and streptokinase-human plasmin complex . | NA | {
"id": "C0032144",
"name": "plasminogen activator",
"pos": [
112,
133
]
} | {
"id": "C0038418",
"name": "streptokinase",
"pos": [
194,
207
]
} |
as the antigenic specificity of the antibody responsible for these observations is not known , we decided to investigate the effects of monoclonal antibodies directed against the individual measles polypeptides . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
36,
44
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
136,
157
]
} |
comparative antigenic analysis of epidemic influenza virus strains has allowed the description of 'strain-specific ' and 'cross-reactive ' antigenic determinants . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
12,
21
]
} | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
139,
161
]
} |
thus , in characterizing the antigenic structure of the ha molecule , our approach has been ( 1 ) to generate a panel of monoclonal anti-ha hybridoma antibodies , ( 2 ) to use some of these antibodies to select mutants of the influenza a/pr/8/34 ( pr8 ) virus expressing antigenically altered ha molecules , and ( 3 ) to construct an operational antigenic map of the ha molecule by comparative antigenic analysis of the mutant viruses with the monoclonal antibodies . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
150,
160
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
444,
465
]
} |
c3b , the major cleavage fragment of the third component of complement ( c3 ) , has been demonstrated to bind to a specific receptor on various mammalian cells . | NA | {
"id": "C0009511",
"name": "c3b",
"pos": [
0,
3
]
} | {
"id": "C0009506",
"name": "component",
"pos": [
47,
56
]
} |
these data suggest that after intraventricular application in anaesthetized rats , the effects of these alpha-adrenoceptor blockers are related to their individual affinity for the alpha 2 adrenoceptor . | NA | {
"id": "C0034784",
"name": "alpha-adrenoceptor",
"pos": [
104,
122
]
} | {
"id": "C0001639",
"name": "alpha 2 adrenoceptor",
"pos": [
181,
201
]
} |
the following performance criteria are presented : precision , accuracy , detectability ( 40 pg/ml for adrenaline and noradrenaline , 130 pg/ml for dopamine ) , linearity and day-by-day variation . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
103,
113
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
118,
131
]
} |
the relation between renal vein renin activity ( rvra ) and renal vein-prostaglandin a ( pga ) and prostaglandin e ( pge ) concentrations was examined in 50 patients with hypertension who underwent renal vein catheterizations for suspected renovascular hypertension . | NA | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
71,
84
]
} | {
"id": "C0033559",
"name": "prostaglandin e",
"pos": [
99,
114
]
} |
the tumours had been histologically classified as cellular and fibrillary ependymomas , subependymomas , myxopapillary and malignant ependymomas ( table 1 ) . | NA | {
"id": "C0014474",
"name": "ependymomas",
"pos": [
74,
85
]
} | {
"id": "C0206725",
"name": "subependymomas",
"pos": [
88,
102
]
} |
the normal hypothalamic dopamine levels in dogs with pdh are not consistent with a dopaminergic-depletion as the cause of pdh . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
24,
32
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
83,
95
]
} |
2 patients had pituitary dependent cushing 's disease , 3 non-endocrine neurological disease and 10 non-acth related pituitary disease . | NA | {
"id": "C0014130",
"name": "endocrine",
"pos": [
62,
71
]
} | {
"id": "C0032002",
"name": "pituitary disease",
"pos": [
117,
134
]
} |
an immunohistochemical study of enkephalins and other neuropeptides in the striatum of the cat with evidence that the opiate peptides are arranged to form mosaic patterns in register with the striosomal compartments visible by acetylcholinesterase staining . | NA | {
"id": "C0014298",
"name": "enkephalins",
"pos": [
32,
43
]
} | {
"id": "C0205753",
"name": "opiate peptides",
"pos": [
118,
133
]
} |
an immunohistochemical study of enkephalins and other neuropeptides in the striatum of the cat with evidence that the opiate peptides are arranged to form mosaic patterns in register with the striosomal compartments visible by acetylcholinesterase staining . | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
54,
67
]
} | {
"id": "C0205753",
"name": "opiate peptides",
"pos": [
118,
133
]
} |
present data indicate that valproic acid is able to displace phenytoin from plasma proteins , suggesting a critical evaluation of the routine phenytoin plasma proteins , suggesting a critical evaluation of the routine phenytoin plasma levels ( which reflect free + bound fraction ) when this drug is administered concurrently with sodium valproate . | NA | {
"id": "C0042291",
"name": "valproic acid",
"pos": [
27,
40
]
} | {
"id": "C0037567",
"name": "sodium valproate",
"pos": [
331,
347
]
} |
because acute attacks of porphyria may be precipitated by anticonvulsants , a therapeutic dilemma arises when seizures complicate hepatic porphyria . | NA | {
"id": "C0162565",
"name": "acute",
"pos": [
8,
13
]
} | {
"id": "C0162533",
"name": "hepatic porphyria",
"pos": [
130,
147
]
} |
bath perfusion of normorphine , methionine-enkephalin ( m-e ) or [ d-ala2 , d-leu5 ] -enkephalin ( dadl ) did not alter membrane potential , threshold potential for spike initiation or the spike waveform either before or after addition of ba2+ and 4-aminopyridine . | NA | {
"id": "C0014295",
"name": "methionine-enkephalin",
"pos": [
32,
53
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
86,
96
]
} |
an analysis of the interrelationship of the mixed odontogenic tumors -- ameloblastic fibroma , ameloblastic fibro-odontoma , and the odontomas . | NA | {
"id": "C0028880",
"name": "odontogenic",
"pos": [
50,
61
]
} | {
"id": "C0028882",
"name": "odontomas",
"pos": [
133,
142
]
} |
the mixed odontogenic tumors -- ameloblastic fibroma , ameloblastic fibro-odontoma , and the odontomas -- represent a group of lesions of which some are neoplastic and some are hamartomatous . | NA | {
"id": "C0028880",
"name": "odontogenic tumors",
"pos": [
10,
28
]
} | {
"id": "C0028882",
"name": "odontomas",
"pos": [
93,
102
]
} |
a careful histopathological diagnosis , which may separate other pathological conditions , and an appropriate staging , which may exclude dissemination of disease , are stressed as representing the basis for effective treatment . | NA | {
"id": "C0030660",
"name": "pathological",
"pos": [
15,
27
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
155,
162
]
} |
the in vitro susceptibilities of 7 commonly isolated species of bacteria to cephalothin , cefoxitin , and 3 new cephalosporins -- cephamandole , cefuroxime , and cefoperazone -- were studied using an agar dilution method . | NA | {
"id": "C0007541",
"name": "cephamandole",
"pos": [
130,
142
]
} | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
162,
174
]
} |
the term lethal neonatal dwarfism ( death dwarfism ) denotes bone dysplasias which always have a fatal outcome . | NA | {
"id": "C0013336",
"name": "dwarfism",
"pos": [
25,
33
]
} | {
"id": "C0005941",
"name": "bone dysplasias",
"pos": [
61,
76
]
} |
menkes fibroblasts contain a significantly greater amount of cysteine-rich 10,000 dalton copper-binding protein ( s ) ( metallotheionein ) than normal cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
7,
18
]
} | {
"id": "C0007634",
"name": "normal cells",
"pos": [
144,
156
]
} |
using five lines of nf cells , age- and passage-matched to normal controls , we found that nf fibroblasts grew more slowly and stopped growing at a lower population density than normal cells ( p less than 0.0005 ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
94,
105
]
} | {
"id": "C0007634",
"name": "normal cells",
"pos": [
178,
190
]
} |
the same cells also incorporated [ 3h ] thymidine at a lower rate than normal skin fibroblasts ( 9,330 +/- 3,240 versus 42,100 +/- 6,840 ; p less than 0.01 ) . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
9,
14
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
83,
94
]
} |
nf cells ( n = 5 ) were found to be morphologically different from normal skin fibroblasts ( n = 5 ) in culture by light microscopy . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
3,
8
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
79,
90
]
} |
using a marker perfusing technique , the jejunal absorption rates of glycine and phenylalanine from test solutions containing either the free amino acids or glycyl-phenylalanine ( 30 mm each ) were studied in five children with active celiac disease and in three controls . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
69,
76
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
142,
153
]
} |
thus , amino acid absorption is higher from peptide-linked glycine and phenylalanine , and the advantage of individual amino acid absorption from dipeptide seems to be maintained in the disease state . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
59,
66
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
119,
129
]
} |
six patients with pseudomembranous colitis unrelated to lincomycin or clindamycin treatment were investigated for signs of localised or diffuse cytomegalovirus ( cmv ) infection . | NA | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
56,
66
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
70,
81
]
} |
cytomegalic cells with nuclear inclusion bodies were found in the rectal mucosa of 5 patients , 4 of whom also had foci of cmv-infected cells in leucocyte-fibroblast cultures , indicative of viraemia . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
12,
17
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
155,
165
]
} |
forty-five patients in deep coma resulting from head injury were treated with pentobarbital in doses adjusted to maintain serum barbiturate levels between 15 and 25 mg/l and short burst suppression phases on eeg . | NA | {
"id": "C0030883",
"name": "pentobarbital",
"pos": [
78,
91
]
} | {
"id": "C0004745",
"name": "barbiturate",
"pos": [
128,
139
]
} |
they found that steatonecrosis precedes acinic lesions and hypothesize that it might be responsible for necrosis of the glandular tissue . | NA | {
"id": "C0015668",
"name": "steatonecrosis",
"pos": [
16,
30
]
} | {
"id": "C0027540",
"name": "necrosis",
"pos": [
104,
112
]
} |
[ adrenocortical scintigraphy with 131i-19-iodocholesterol . indications and results in 66 cases of hypercortisolism and hyperaldosteronism ( author 's transl ) ] . | NA | {
"id": "C0001622",
"name": "hypercortisolism",
"pos": [
100,
116
]
} | {
"id": "C0020428",
"name": "hyperaldosteronism",
"pos": [
121,
139
]
} |
p106 specifies the last actin amino acid codon , the termination codon and the entire 3 ' non-translated region . | NA | {
"id": "C0009221",
"name": "codon",
"pos": [
41,
46
]
} | {
"id": "C0242611",
"name": "termination codon",
"pos": [
53,
70
]
} |
rna/protein binding experiments with isolated components , and analysis of reformed rnp complexes in cscl gradients , demonstrate that the stable interactions are : 5s rna/p45 , 3 ( trna ) /p45 , 5s rna/p39 and 5s rna/p45/p39 . | NA | {
"id": "C0085177",
"name": "rna/protein binding",
"pos": [
0,
19
]
} | {
"id": "C0035544",
"name": "rnp",
"pos": [
84,
87
]
} |
it is suggested that the 40s rnp particle not only stores 5s rna and trna but also provides a means for the exchange of the 5s rna transcript binding protein ( p45 ) for the 5s rna ribosome associated protein ( p39 ) . | NA | {
"id": "C0035544",
"name": "rnp",
"pos": [
29,
32
]
} | {
"id": "C0085177",
"name": "rna",
"pos": [
177,
180
]
} |
the results obtained with salicylic acid ointments by the lipophil collodion-lipid membranes and silicone membranes developed by furst and coworkers [ 14 ] were comparable with those yielded by the hydrophilic cellulose membrane : release rates of comparable order of magnitude ; | NA | {
"id": "C0009356",
"name": "collodion",
"pos": [
67,
76
]
} | {
"id": "C0007648",
"name": "cellulose",
"pos": [
210,
219
]
} |
experiments have been performed to optimize the composition of tablets with 250 mg of noramidopyrine methanesulphonate sodium , 250 mg of aminophenazone and 100 mg of caffeine + sodium benzoate . | NA | {
"id": "C0012586",
"name": "noramidopyrine methanesulphonate sodium",
"pos": [
86,
125
]
} | {
"id": "C0002586",
"name": "aminophenazone",
"pos": [
138,
152
]
} |
one property , mediation of exchange transport , suggests that amino acid influx is coupled to efflux , particularly efflux of glutamine , synthesized in glial astrocytes from ammonia and glutamic acid . | NA | {
"id": "C0017797",
"name": "glutamine",
"pos": [
127,
136
]
} | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
188,
201
]
} |
due to the pathogenetic and pathomorpohologic similarities of silicosis and tuberculosis , it is often difficult and sometimes even impossible to recognise the presence of tuberculosis in cases of silicoses or to identify and isolate the tb component in silicotuberculosis . | NA | {
"id": "C0037116",
"name": "silicoses",
"pos": [
197,
206
]
} | {
"id": "C0037118",
"name": "silicotuberculosis",
"pos": [
254,
272
]
} |
( i ) the mixture of dipalmitoyl phosphatidyl choline and dioleyl phosphatidyl choline shows a periodic structure . | NA | {
"id": "C0000039",
"name": "dipalmitoyl phosphatidyl choline",
"pos": [
21,
53
]
} | {
"id": "C1959616",
"name": "phosphatidyl",
"pos": [
66,
78
]
} |
in both cases levels of the progesterone metabolite 20 alpha hydroxypregn-4-ene-3-one ( 20 alpha-ohp ) were less than 2 percent of progesterone levels and declined in a manner similar to progesterone . | NA | {
"id": "C0012311",
"name": "20 alpha hydroxypregn-4-ene-3-one",
"pos": [
52,
85
]
} | {
"id": "C0033308",
"name": "progesterone",
"pos": [
187,
199
]
} |
stimulation of the entire spinal cord ( 50v , 0.3-3 hz , 1.0 msec ) of the pithed rat increased blood pressure , heart rate and plasma epinephrine ( epi ) and norepinephrine ( ne ) concentration ( radioenzymatic-thin layer chromatographic assay ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
135,
146
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
159,
173
]
} |
infusion of pge2 ( 10-30 microgram/kg . min , i.v . ) suppressed blood pressure and heart rate responses to spinal cord stimulation while plasma epi ( but not ne ) was augmented over levels found in control animals . | NA | {
"id": "C0014563",
"name": "epi",
"pos": [
145,
148
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
159,
161
]
} |
the in vivo model systems discussed in this study , utilizing the synthetic form of lte4 should be useful in the future evaluation of other srs-a antagonists . | NA | {
"id": "C0125644",
"name": "lte4",
"pos": [
84,
88
]
} | {
"id": "C0038091",
"name": "srs-a",
"pos": [
140,
145
]
} |
decreases in hepatic aryl hydrocarbon hydroxylase , 7-ethoxycoumarin o-dethylase and aniline hydroxylase with advanced age have also previously been reported for this strain of mouse . | NA | {
"id": "C0003927",
"name": "aryl",
"pos": [
21,
25
]
} | {
"id": "C0003039",
"name": "aniline hydroxylase",
"pos": [
85,
104
]
} |
although immediate recovery from these nephrotoxic effects of aminoglycosides and the elevation of urinary nag activity occurs on prompt withdrawal of the drugs , two autopsied cases receiving prolonged administration of gentamicin , followed marked nag elevation , show necrosis and exfoliation of tubular epithelial cells with little glomerular injury . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
62,
77
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
221,
231
]
} |
levels of antibiotic in human blood and interstitial fluid after oral administration of bacampicillin or phenoxymethyl penicillin and intravenous administration of amoxicillin or ampicillin . | NA | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
164,
175
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
179,
189
]
} |
levels of antibiotic in the serum and interstitial fluid were determined for 11 volunteers who received conventional doses of either phenoxymethyl penicillin ( penicillin v ) or bacampicillin orally and for 11 volunteers who received either amoxicillin or ampicillin intravenously . | NA | {
"id": "C0052865",
"name": "orally",
"pos": [
192,
198
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
256,
266
]
} |
levels of antibiotic in the serum and interstitial fluid were determined for 11 volunteers who received conventional doses of either phenoxymethyl penicillin ( penicillin v ) or bacampicillin orally and for 11 volunteers who received either amoxicillin or ampicillin intravenously . | NA | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
241,
252
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
256,
266
]
} |
the levels of antibiotic in serum and interstitial fluid of participants in the study who received amoxicillin or ampicillin intravenously were comparable with those achieved with equivalent doses of oral bacampicillin . | NA | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
99,
110
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
208,
218
]
} |
the lowest levels of antibiotic in serum and interstitial fluid were obtained in volunteers who received oral penicillin v , whereas the highest levels were obtained in those given ampicillin and amoxicillin intravenously . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
181,
191
]
} | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
196,
207
]
} |
comparison of bacampicillin twice daily and ampicillin four times daily in treatment of acute exacerbations of chronic bronchitis . | NA | {
"id": "C0052865",
"name": "twice daily",
"pos": [
28,
39
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
44,
54
]
} |
bacampicillin administered twice daily may offer several advantages over drugs given three times a day ( e.g. , amoxicillin ) or four times a day ( e.g. , ampicillin ) . | NA | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
112,
123
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
155,
165
]
} |
the regimens included 2.4 g of bacampicillin plus 1.0 g of probenecid , 1.6 g of bacampicillin plus 1.0 g of probenecid , and 3.5 g of ampicillin plus 1.0 g of probenecid . | NA | {
"id": "C0052865",
"name": "plus",
"pos": [
45,
49
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
135,
145
]
} |
when the translation was performed in the presence of microsomal membranes from dog pancreas the glycophorin a apoprotein aws both n-and o-glycosylated and the apparent molecular weight ( 37000 ) of the synthesized protein was identical to that of the precursor obtained from cells . | NA | {
"id": "C0003601",
"name": "apoprotein",
"pos": [
111,
121
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
215,
222
]
} |
some discrepancy in the estimated potency was observed between methods used for the assay of thrombin , fviii and several other clotting factors and their inhibitors . | NA | {
"id": "C0040018",
"name": "thrombin",
"pos": [
93,
101
]
} | {
"id": "C0005789",
"name": "clotting factors",
"pos": [
128,
144
]
} |
depletion of adherent cells of the mononuclear cell suspensions by nylon wool column fractionation or by incubation on plastic dishes and depletion of cells which had phagocytosed colloidal iron had no substantial effect on the cytotoxicity whereas depletion of cells forming rosettes with human erythrocytes sensitized with human igg ( ea-rfc ) practically abolished the activity . | NA | {
"id": "C0028736",
"name": "nylon",
"pos": [
67,
72
]
} | {
"id": "C0032167",
"name": "plastic",
"pos": [
119,
126
]
} |
cyclosporin a may give rise to a whole range of side effects and its use -- like that of other immunosuppressants -- should therefore be contemplated only in severe and progressive forms of psoriasis and psoriatic arthritis resistant to other forms of treatment except cytostatic drugs . | NA | {
"id": "C0033860",
"name": "psoriasis",
"pos": [
190,
199
]
} | {
"id": "C0003872",
"name": "psoriatic arthritis",
"pos": [
204,
223
]
} |
circulating immune complexes and precipitins against the contaminated humidifier water and cheese mites were found , but no antibodies suggesting legionnaires ' disease . | NA | {
"id": "C0003313",
"name": "circulating immune complexes",
"pos": [
0,
28
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
124,
134
]
} |
circulating immune complexes and precipitins against the contaminated humidifier water and cheese mites were found , but no antibodies suggesting legionnaires ' disease . | NA | {
"id": "C0032936",
"name": "precipitins",
"pos": [
33,
44
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
124,
134
]
} |
determination of hdl-cholesterol should therefore be confined to borderline cases of hypercholesteremia ( cholesterol 240-300 mg/100 ml ) to provide a further argument for or against lipid-lowering treatment . | NA | {
"id": "C0023822",
"name": "hdl-cholesterol",
"pos": [
17,
32
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
106,
117
]
} |
the study of the associated diseases shows the high incidence of the tumors ( 23 % ) , benign and malignant ( 13 % ) and of the cysts in other organs ( 5 % ) . | NA | {
"id": "C0027651",
"name": "tumors",
"pos": [
69,
75
]
} | {
"id": "C0010709",
"name": "cysts",
"pos": [
128,
133
]
} |
pituitary abscess is rare and should be suspected in patients with hypopituitarism or a febrile chiasma syndrome as well as in the presence of acute or chronic relapsing aseptic meningitis . | NA | {
"id": "C0032002",
"name": "pituitary",
"pos": [
0,
9
]
} | {
"id": "C0020635",
"name": "hypopituitarism",
"pos": [
67,
82
]
} |
cholecystoses imply a benign proliferation of normal tissue elements , whereas cholecystosis indicates a pathologic process that is distinct from inflammation . | NA | {
"id": "C0030660",
"name": "pathologic process",
"pos": [
105,
123
]
} | {
"id": "C0021368",
"name": "inflammation",
"pos": [
146,
158
]
} |
in the iron overload states , the test had been performed in 2 subgroups of patients : chronic anemic patients with transfusional iron overload and hemochromatosis without anemia . | NA | {
"id": "C0282193",
"name": "iron overload",
"pos": [
7,
20
]
} | {
"id": "C0018995",
"name": "hemochromatosis",
"pos": [
148,
163
]
} |
clinical evaluation of every extremity injury must be tempered by suspicion and vigilance to detect compartment syndromes early enough to prevent ischemic contracture . | NA | {
"id": "C0009492",
"name": "compartment syndromes",
"pos": [
100,
121
]
} | {
"id": "C0042951",
"name": "ischemic contracture",
"pos": [
146,
166
]
} |
the change in hba1 observed during pregnancy may be due to lower fasting glucose concentrations , but other physiologic changes of pregnancy such as expansion of the red cell mass and variations in fetal hemoglobin levels also may contribute to the decrease in hba1 in the third trimester of pregnancy . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
35,
44
]
} | {
"id": "C0032981",
"name": "third trimester",
"pos": [
273,
288
]
} |
our case illustrates that arthritis due to yersinia may mimic acute rheumatic fever both clinically and serologically . | NA | {
"id": "C0003864",
"name": "arthritis",
"pos": [
26,
35
]
} | {
"id": "C0035436",
"name": "acute rheumatic fever",
"pos": [
62,
83
]
} |
half-lives of the antigens could not be calculated from the arrhenius equation because the response curves at each temperature followed different kinetics . | NA | {
"id": "C0018517",
"name": "half-lives",
"pos": [
0,
10
]
} | {
"id": "C0022702",
"name": "kinetics",
"pos": [
146,
154
]
} |
the additive model pertained to fusions made in cell suspensions and the multiplicative one mainly to fusions in fibroblast monolayers . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
48,
52
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
113,
123
]
} |
single dose dexamethasone suppression test with adrenocorticotropic hormone stimulation , and analysis of 24 hour urinary excretion of epinephrine and norepinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
135,
146
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
151,
165
]
} |
in all seven patients , the plasma cortisol levels , dexamethasone suppression -- adrenocorticotropic hormone stimulation test results and urinary excretion of epinephrine and norepinephrine were similar to those found in comparable patients without adrenal metastases . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
160,
171
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
176,
190
]
} |
sixty male swiss-webster mice were given intraperitoneal injections of the gold-containing drug aurothioglucose in saline at 3 dose levels : 50 , 200 , and 400 mg/kg . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
75,
79
]
} | {
"id": "C0018033",
"name": "aurothioglucose",
"pos": [
96,
111
]
} |
tubular epithelial cells of aurothioglucose-dosed animals often had cytoplasmic vacuoles which contained granular brown-gold material ; | NA | {
"id": "C0018033",
"name": "aurothioglucose",
"pos": [
28,
43
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
120,
124
]
} |
these substrates can be used for measuring the 16 alpha hydroxylase activity , an important step in the biosynthesis of estriol ( viii ) and estetrol ( ix ) . | NA | {
"id": "C0014927",
"name": "estriol",
"pos": [
120,
127
]
} | {
"id": "C0014899",
"name": "estetrol",
"pos": [
141,
149
]
} |
no disorders were found in the free amino acid ratio in liver tissue of animals who had received liquid diet in which the protein component was represented by casein ( 73 % ) and milk serum proteins ( 27 % ) . | NA | {
"id": "C0007332",
"name": "casein",
"pos": [
159,
165
]
} | {
"id": "C0026138",
"name": "milk",
"pos": [
179,
183
]
} |
which is the foreseeable future role of ethanol fractionation for the production of the main fractions albumin and immunoglobulins , as well as for the preparation of concentrates of trace proteins like coagulation factors ? | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
103,
110
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
189,
197
]
} |
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