text
stringlengths 57
1.72k
| relation
stringclasses 125
values | h
dict | t
dict |
|---|---|---|---|
binder iiia has been separated chromatographically from the glutathione s-transferases ( including ligandin ) and protein z described by arias [ levi , a.j. , gatmaitan , z. and arias , i.m . ( 1969 ) j. clin . invest . 48 , 21856-21866 ] , both of which have been shown to bind anionic metabolites . | NA | {
"id": "C0021966",
"name": "i",
"pos": [
1,
2
]
} | {
"id": "C0003075",
"name": "anionic",
"pos": [
279,
286
]
} |
we conclude from our results that bt2camp induces the synthesis of tyrosine aminotransferase by an increase in the rate of initiation on the tyrosine aminotransferase mrna . | NA | {
"id": "C0002594",
"name": "aminotransferase",
"pos": [
76,
92
]
} | {
"id": "C0041487",
"name": "tyrosine aminotransferase",
"pos": [
141,
166
]
} |
the very restricted cleavage of peptide bonds in denatured collagens can be ascribed to the infrequent occurrence of groupings of more than two hydrophobic residues and to the high content of the conformation-limiting residues proline and hydroxyproline . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
227,
234
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
239,
253
]
} |
in this paper we examined whether the haem-regulated inhibitor produced by treating postribosomal supernatant with n-ethylmaleimide and the inhibitor generated by heating at 44 degrees c in the presence of haemin are the same molecular entity . | NA | {
"id": "C0018966",
"name": "haem",
"pos": [
38,
42
]
} | {
"id": "C0018988",
"name": "haemin",
"pos": [
206,
212
]
} |
the calculation of product formation has been applied to the production of hydrogen by hydrogenase in a system with a redox mediator , whose reduced form functions as the ultimate electron donor for hydrogenase , and the dithionite/ ( bi ) sulphite redox couple as reducing system . | NA | {
"id": "C0012787",
"name": "dithionite",
"pos": [
221,
231
]
} | {
"id": "C0038750",
"name": "sulphite",
"pos": [
240,
248
]
} |
these actions of albumin are abolished only when albumin is preloaded with four molecules of oleic acid per protein molecule . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
17,
24
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
108,
115
]
} |
a preparative method for the isolation of the lipid free apoprotein , the ca2+-atpase of sarcoplasmic reticulum , from the partially purified lipoprotein , ca2+-atpase vesicles , is presented . | NA | {
"id": "C0916181",
"name": "ca2",
"pos": [
74,
77
]
} | {
"id": "C0001476",
"name": "ca2",
"pos": [
156,
159
]
} |
the beta 1-adrenergic nature of the receptors was derived from the order of potencies of beta-adrenergic agonists ( isoproterenol greater than norepinephrine greater than epinephrine ) to complete with ( -- ) - [ 3h ] dihydroalprenolol for binding . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
143,
157
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
171,
182
]
} |
a comparative analysis of the ribosomal proteins split off by kcl , the core proteins , the proteins transferable between the two subunits and the proteins labelled in absence of ribosomal synthesis . | NA | {
"id": "C0035552",
"name": "ribosomal",
"pos": [
30,
39
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
147,
155
]
} |
the purified enzyme reassociates with the residual complex lacking this component to a fully active enzyme complex . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
13,
19
]
} | {
"id": "C0026741",
"name": "enzyme complex",
"pos": [
100,
114
]
} |
pyruvate exerts a cooperative effect both upon the partial enzyme reaction of the pyruvate dehydrogenase component as well as upon the overall reaction of the native enzyme complex . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
59,
65
]
} | {
"id": "C0026741",
"name": "enzyme complex",
"pos": [
166,
180
]
} |
experiments with the free enzyme , with the component integrated into the native complex molecule and with enzyme complexes which are partially deficient in the pyruvate dehydrogenase component demonstrate that the type of saturation curves obtained were characteristic for the reaction observed rather than for the interaction of a high number of subunits of the pyruvate dehydrogenase complex . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
26,
32
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
107,
113
]
} |
experiments with the free enzyme , with the component integrated into the native complex molecule and with enzyme complexes which are partially deficient in the pyruvate dehydrogenase component demonstrate that the type of saturation curves obtained were characteristic for the reaction observed rather than for the interaction of a high number of subunits of the pyruvate dehydrogenase complex . | NA | {
"id": "C0026741",
"name": "enzyme",
"pos": [
26,
32
]
} | {
"id": "C0034344",
"name": "pyruvate dehydrogenase complex",
"pos": [
364,
394
]
} |
the transition state activation energy of the catalytic activity is smaller for the complex-bound enzyme than that found for the free enzyme . | NA | {
"id": "C0026741",
"name": "complex",
"pos": [
84,
91
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
134,
140
]
} |
16-s rrna increases the rate of s20 synthesis , the final yield of product depends on the duration of persistence of the rna added . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
5,
9
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
121,
124
]
} |
this study indicates that 11c-methionine brain uptake may be taken as an index of blood barrier permeability to essential amino acids , and of brain maturation . | NA | {
"id": "C0025646",
"name": "methionine",
"pos": [
30,
40
]
} | {
"id": "C0002525",
"name": "essential amino acids",
"pos": [
112,
133
]
} |
extra-renal elimination ( metabolic and biliary ) represented the main route of elimination , with a renal to body clearance ratio of 0.123 . | NA | {
"id": "C1373187",
"name": "renal elimination",
"pos": [
6,
23
]
} | {
"id": "C1373186",
"name": "route of elimination",
"pos": [
71,
91
]
} |
it was determined that the target antigen of anti-t is a 69 000 molecular weight cell surface glycoprotein and that the t3 antigen is a 19 000 mol . wt . glycoprotein . | NA | {
"id": "C0025248",
"name": "cell surface glycoprotein",
"pos": [
81,
106
]
} | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
154,
166
]
} |
spleen cells from chronically infected mice suppressed lymphocyte stimulation induced in normal spleen and lymph node cell populations by con a , lps and allogeneic stimulator cells . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
7,
11
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
154,
164
]
} |
ifn and the lymphokine macrophage-activating factor ( maf ) were compared for their ability to provide the sequence of activation signals to macrophages from the normal responder c3h/hen mice and from c3h/hej mice , which are defective for several macrophage responses . | NA | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
12,
22
]
} | {
"id": "C0079786",
"name": "macrophage-activating factor",
"pos": [
23,
51
]
} |
naltrexone , a congener of naloxone , was more potent than naloxone in reducing isoproterenol-induced water intake . | NA | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
0,
10
]
} | {
"id": "C0027358",
"name": "naloxone",
"pos": [
59,
67
]
} |
schedule-induced polydipsia , which occurs in the absence of body fluid deficits , was not altered by either naloxone or naltrexone at doses attenuating drinking induced by the other methods . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
109,
117
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
121,
131
]
} |
acute sino-aortic denervation produces an acute reduction of adrenaline stores in the anterior and posterior hypothalamus and a reduction of noradrenaline stores in the dorsal midline area of the caudal medulla oblongata . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
61,
71
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
141,
154
]
} |
unlabelled noradrenaline ( 0.1 micrometer ) , alpha-methyl-noradrenaline ( 0.01-0.1 micrometer ) , xylazine ( 0.1-10 micrometer ) and guanabenz ( 0.01 micrometer ) decreased , whereas yohimbine ( 0.01-1 micrometer ) , rauwolscine ( 0.01-1 micrometer ) , corynanthine ( 10 micrometers ) , tolazoline ( 0.1-10 micrometers ) and azapetine ( 0.1-1 micrometer ) increased the stimulation-evoked overflow of tritium without a change in basal outflow . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
11,
24
]
} | {
"id": "C0025805",
"name": "alpha-methyl-noradrenaline",
"pos": [
46,
72
]
} |
kainic acid lesion of rat striata reduces the specific dopamine receptor binding of the butyrophenone antagonist [ 3h ] spiperone and the butyrophenone-like antagonist [ 3h ] domperidone by 56 % and 59 % respectively . | NA | {
"id": "C0037956",
"name": "spiperone",
"pos": [
120,
129
]
} | {
"id": "C0006525",
"name": "butyrophenone",
"pos": [
138,
151
]
} |
norepinephrine ( ne ) and epinephrine ( e ) suppressed field potentials elicited by a single shock to the stria terminalis ( st ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
0,
14
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
26,
37
]
} |
the action of inhibitory amino acid transmitters gaba , glycine , beta-alanine and taurine has been studied on the membrane potential of cultured astrocytes and on the extracellular k+-concentration ( [ k+ ] 0 ) using k+-sensitive microelectrodes . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
25,
35
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
56,
63
]
} |
further , two systems are discussed that served as differentiation markers on lymphocytes : the ly antigens and a family of large cell surface membrane proteins ( lmps ) . | NA | {
"id": "C0003324",
"name": "differentiation markers",
"pos": [
51,
74
]
} | {
"id": "C0003334",
"name": "ly antigens",
"pos": [
96,
107
]
} |
destruction of ca3-4 blocks the ability of met-enkephalin , ketocyclazocine , and 5-hydroxytryptophan , but not sodium valproate or ice water to induce withdrawal-like behaviors . | NA | {
"id": "C0020746",
"name": "ice",
"pos": [
132,
135
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
136,
141
]
} |
sodium valproate , ice water , and withdrawal itself are released by naloxone and blocked by opiate agonists . | NA | {
"id": "C0020746",
"name": "ice",
"pos": [
19,
22
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
23,
28
]
} |
drugs that wholly or largely fulfill these criteria are 3-isobutyl-1-methylxanthine ( ibmx ) , theophylline , caffeine , ici 63197 , and ro 201724 . | NA | {
"id": "C0000096",
"name": "3-isobutyl-1-methylxanthine",
"pos": [
56,
83
]
} | {
"id": "C0039771",
"name": "theophylline",
"pos": [
95,
107
]
} |
partial characterization of the active protein resulted in the conclusion that inhibin from bovine follicular fluid is a hydrophobic glycoprotein with an apparent molecular weight between 60 000 and 70 000 daltons . | NA | {
"id": "C0021463",
"name": "inhibin",
"pos": [
79,
86
]
} | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
133,
145
]
} |
a size preference appears to exist , since oligosaccharides of dp4-10 liberated by a gastric hyaluronidase-like enzyme is a poor substrate for desulfation by the gastric enzyme complex . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
112,
118
]
} | {
"id": "C0026741",
"name": "enzyme complex",
"pos": [
170,
184
]
} |
it is suggested that in these cases of alcoholic liver disease there is loss of tolerance , and continued production of anti-lsp could promote periportal inflammation and accelerate the progression to cirrhosis . | NA | {
"id": "C0023895",
"name": "of",
"pos": [
36,
38
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
201,
210
]
} |
serum iron and transferrin should be determined in all patients with arthralgias , since arthropathy may be the first clinical sign of hemochromatosis . | NA | {
"id": "C0003862",
"name": "arthralgias",
"pos": [
69,
80
]
} | {
"id": "C0022408",
"name": "arthropathy",
"pos": [
89,
100
]
} |
26 women were treated for osteoporosis with 40 mg of sodium fluoride twice a day ( equivalent 36 mg of fluorine ) for a longer period . | NA | {
"id": "C0037508",
"name": "sodium fluoride",
"pos": [
53,
68
]
} | {
"id": "C0016327",
"name": "fluorine",
"pos": [
103,
111
]
} |
[ hemoglobins , xxxvi : the primary structure of a dimeric insect hemoglobin ( erythrocruorin ) , component ix from chironomus thummi thummi . | NA | {
"id": "C0019046",
"name": "hemoglobins",
"pos": [
2,
13
]
} | {
"id": "C0019016",
"name": "a",
"pos": [
49,
50
]
} |
dependent on enzyme concentration , however , granulocytic elastase induced progressive inactivation of antithrombin iii leading to an almost complete loss of the thrombin inhibitory activity at a molar ratio of elastase : antithrombin iii = 0.4:1 within 5 min at 25 degrees c . | NA | {
"id": "C0064833",
"name": "granulocytic elastase",
"pos": [
46,
67
]
} | {
"id": "C0030306",
"name": "elastase",
"pos": [
212,
220
]
} |
the synthesis is described of a suitably protected decapeptide derivative corresponding to the c-terminal tyrosin-o-sulfate-containing sequence 24 -- 33 of cholecystokinin-pancreozymin as key fragment for the total synthesis of this gastrointestinal hormone or its 39-variant . | NA | {
"id": "C0008328",
"name": "cholecystokinin-pancreozymin",
"pos": [
156,
184
]
} | {
"id": "C0017182",
"name": "gastrointestinal hormone",
"pos": [
233,
257
]
} |
a case of angiolymphoid hyperplasia ( ahe ) with eosinophilia presenting with recurrent inguinal swellings simulating lymphadenopathy is described . | NA | {
"id": "C0002989",
"name": "angiolymphoid hyperplasia",
"pos": [
10,
35
]
} | {
"id": "C0014457",
"name": "eosinophilia",
"pos": [
49,
61
]
} |
ultrastructurally , spindle shaped cells resembled fibroblasts and , in a few cells , intracellular collagen fibres were seen . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
51,
62
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
78,
83
]
} |
the presence of numerous lipid inclusions in many of the tumour cells , which are otherwise ultrastructurally similar to fibroblast , suggests that these cells represent precursors of lipoblasts . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
121,
131
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
154,
159
]
} |
five insulin independent and three insulin dependent human diabetic patients and their age and sex matched controls were studied . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
5,
12
]
} | {
"id": "C0795635",
"name": "insulin",
"pos": [
35,
42
]
} |
such target-specific inhibition is consistent with the hypothesis that cytotoxic human monocytes recognize various targets through surface receptors which interact with specific monosacchardies , disaccharide , and oligosaccharide sequences present on the target surface . | NA | {
"id": "C0012611",
"name": "disaccharide",
"pos": [
196,
208
]
} | {
"id": "C0028959",
"name": "oligosaccharide",
"pos": [
215,
230
]
} |
mouse-immunoglobulin ( mig ) tolerant rabbits immunized with mouse h-2 antibodies produced anti-idiotype antisera , which were reactive towards specific b- and t-cell receptors . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
71,
81
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
105,
113
]
} |
the 5936-id were found to be associated with ig-1b allotypes and the h-2b complex may contain immune response ( ir ) genes which , in comparison with ir genes in h-2d and h-2s , favor the expression of 5936-id. -- adsorption of 5936-id+ b6 anti-cba mig preparations on cba ( iak ) spleen cells demonstrated that cba antibodies were 5936-id- . | NA | {
"id": "C0021006",
"name": "ig",
"pos": [
45,
47
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
316,
326
]
} |
these cells responded to epinephrine and norepinephrine by increasing both synthesis and release of renin . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
25,
36
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
41,
55
]
} |
to test the role of central neurogenic factors in sodium-depleted states , cerebrospinal fluid ( csf ) norepinephrine , epinephrine , and dopamine were measured in mongrel dogs first on a normal sodium intake ( 65 meq sodium/day ) and then on a 21-day regime of low sodium diet ( 4 meq/day combined with diuretics ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
103,
117
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
120,
131
]
} |
similarly , blockade of angiotensin ii by saralasin induced a comparable fall in blood pressure in both groups . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
24,
38
]
} | {
"id": "C0036193",
"name": "saralasin",
"pos": [
42,
51
]
} |
although endotoxic lipid a was inactive , mitogenic activity of lipopolysaccharide was exhibited by purified preparations of polysaccharides i and ii , which constitute the carbohydrate moiety of the macromolecule . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
19,
26
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
64,
82
]
} |
human lung fibroblasts were grown in different serum concentrations , plated at different densities , and grown for different periods of time to alter the metabolic activity of the cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
11,
22
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
177,
180
]
} |
after opsonization with whole immune sera ( with antibody and total complement pathway ) , heat-inactivated immune sera ( with antibody alone ) , or magnesium dichloride-ethylene glycol tetraacetic acid-chelated immune sera ( with antibody and alternative complement pathway ) , live s. pneumoniae cells were incubated at 37 degrees c with normal polymorphonuclear leukocytes while serial chemiluminescence measurements were recorded . | NA | {
"id": "C0020960",
"name": "immune sera",
"pos": [
30,
41
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
231,
239
]
} |
purified lipopolysaccharide ( lps ) from smooth ( s ) and rough ( r ) strains of brucella abortus and lipid a isolated from s-lps by mild acid hydrolysis were examined in several assays of biological activity . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
102,
109
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
126,
129
]
} |
previously reported mitogenic activation by brucella lpss of spleen cells from endotoxin-resistant c3h/hej mice was confirmed and also produced by isolated brucella lipid a . | NA | {
"id": "C0023810",
"name": "lpss",
"pos": [
53,
57
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
79,
88
]
} |
previously reported mitogenic activation by brucella lpss of spleen cells from endotoxin-resistant c3h/hej mice was confirmed and also produced by isolated brucella lipid a . | NA | {
"id": "C0023810",
"name": "lpss",
"pos": [
53,
57
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
165,
172
]
} |
s and r brucella lpss and lipid a all produced equivalent polyclonal stimulation of c3h/hej and c3h/heau spleen cells . | NA | {
"id": "C0023810",
"name": "lpss",
"pos": [
17,
21
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
26,
33
]
} |
the participation of the protein strongly bound to the lipid a can not be excluded , but its mode of action , if any , is different from that of the lipid a-associated protein of enterobacterial lps . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
55,
62
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
195,
198
]
} |
the presence of choriogonadotropin- and alpha-subunit-like materials in two species of bacteria identified as staphylococcus simulans and streptococcus faecalis have been demonstrated by the indirect fluorescein-labeled and the indirect peroxidase-labeled immunocytochemical techniques , utilizing antiserum for human choriogonadotropin , for its alpha and beta-subunits and the bera-subunit cooh-terminal peptide . | NA | {
"id": "C0018062",
"name": "choriogonadotropin",
"pos": [
16,
34
]
} | {
"id": "C0017963",
"name": "alpha-subunit",
"pos": [
40,
53
]
} |
upon infection , cr antibodies were detected by day 2 postinfection and reached peak titers between 7 and 14 days postinfection in the antisera of all ponies . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
20,
30
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
135,
143
]
} |
fractionation of 1-week and 2-week postinfection antisera of group i ponies indicated the cr antibody activity resided in both the 7s and 19s fractions . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
49,
57
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
93,
101
]
} |
the sixth volunteer , who had a low titer of preexisting dengue-2 neutralizing antibody , had no viremia , no symptoms , and a modest rise in hemagglutination inhibiting antibody . | NA | {
"id": "C0475463",
"name": "neutralizing antibody",
"pos": [
66,
87
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
170,
178
]
} |
in contrast , erythematous and edematous rashes were produced after administration of either pe to animals presensitized to homologous toxin . | NA | {
"id": "C0015309",
"name": "pe",
"pos": [
93,
95
]
} | {
"id": "C0040549",
"name": "toxin",
"pos": [
135,
140
]
} |
the assays consist of a double-antibody elisa which utilizes type-specific monkey and mouse coxsackievirus antisera . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
31,
39
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
107,
115
]
} |
a positive correlation was demonstrated between the proportion of black-pigmented bacteroides ( mainly b. melaninogenicus subsp . intermedius ) and both the severity of gingival inflammation and the periodontal pocket depth , suggesting that these organisms may contribute to the pathogenesis of certain forms of periodontal disease . | NA | {
"id": "C0017574",
"name": "gingival inflammation",
"pos": [
169,
190
]
} | {
"id": "C0017563",
"name": "periodontal",
"pos": [
313,
324
]
} |
this naturally expanded population of in-reactive cells has an isotype profile resembling populations arising after intentional priming with other antigens in that it contained a large proportion of cells which generated clones expressing immunoglobulin g and immunoglobulin a isotypes , often without detectable immunoglobulin m . | NA | {
"id": "C0020852",
"name": "immunoglobulin g",
"pos": [
239,
255
]
} | {
"id": "C0021017",
"name": "immunoglobulin",
"pos": [
313,
327
]
} |
this naturally expanded population of in-reactive cells has an isotype profile resembling populations arising after intentional priming with other antigens in that it contained a large proportion of cells which generated clones expressing immunoglobulin g and immunoglobulin a isotypes , often without detectable immunoglobulin m . | NA | {
"id": "C0021017",
"name": "immunoglobulin",
"pos": [
239,
253
]
} | {
"id": "C0020861",
"name": "immunoglobulin m",
"pos": [
313,
329
]
} |
passive protection tests with antisera known to contain antibodies to pertussigen protected mice from intracerebral infection , whereas sera lacking anti-pertussigen antibodies but containing high concentrations of anti-fha antibodies did not protect mice . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
30,
38
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
224,
234
]
} |
the microfilament-disrupting agents cytochalasins a , b , and d were shown to impair the binding of the chemotactic factors [ 3h ] formylmethionylleucylphenylalanine and 125 i-labeled crystal-induced chemotactic factor to their neutrophil receptor . | NA | {
"id": "C0008013",
"name": "chemotactic factors",
"pos": [
104,
123
]
} | {
"id": "C0027229",
"name": "formylmethionylleucylphenylalanine",
"pos": [
131,
165
]
} |
the capsular polysaccharide type did not determine the adhesive capacity of the strains , but otitis strains belonging to the capsular types often associated with otitis media adhered in high numbers . | NA | {
"id": "C0029877",
"name": "otitis",
"pos": [
94,
100
]
} | {
"id": "C0029882",
"name": "otitis media",
"pos": [
163,
175
]
} |
different classes of immunoglobulins ( immunoglobulin m [ igm ] , igg , and secretory iga ) were purified from pooled serum and milk samples of convalescent cholera patients by gel filtration and immunoadsorbent techniques . | NA | {
"id": "C0021017",
"name": "classes",
"pos": [
10,
17
]
} | {
"id": "C0020861",
"name": "immunoglobulin m",
"pos": [
39,
55
]
} |
cutaneous biopsies of lesions were nonspecific but provided no evidence for other explanations for the dermatitis which appears to be an analogue of human atopic dermatitis . | NA | {
"id": "C0011603",
"name": "dermatitis",
"pos": [
103,
113
]
} | {
"id": "C0011615",
"name": "atopic dermatitis",
"pos": [
155,
172
]
} |
these antigens may be clinically relevant since coffee workers sensitized to castor have ige antibodies to both allergens . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
6,
14
]
} | {
"id": "C0002092",
"name": "allergens",
"pos": [
112,
121
]
} |
these observations suggest that the action of dibutyryl-cyclic gmp is not due to elevation of cyclic gmp levels and that cyclic gmp levels do not play a major role in c2 production by monocytes . | NA | {
"id": "C0012055",
"name": "dibutyryl-cyclic gmp",
"pos": [
46,
66
]
} | {
"id": "C0018338",
"name": "cyclic gmp",
"pos": [
121,
131
]
} |
it is demonstrated that equilibration is a particular process typical for each amino acid which after 8 hour is nearly complete only for glycine , alanine and asparagine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
79,
89
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
137,
144
]
} |
it is demonstrated that equilibration is a particular process typical for each amino acid which after 8 hour is nearly complete only for glycine , alanine and asparagine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
79,
89
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
147,
154
]
} |
effects of temperature on the removal of urea as ammonia by enzymatic conversion and by gas absorption using an oxygenator . | NA | {
"id": "C0002607",
"name": "ammonia",
"pos": [
49,
56
]
} | {
"id": "C0017110",
"name": "gas",
"pos": [
88,
91
]
} |
ammonium and bicarbonate can be removed using a gas absorption unit ( e.g . oxygenator ) to remove ammonia gas and carbon dioxide . | NA | {
"id": "C0002607",
"name": "ammonia",
"pos": [
99,
106
]
} | {
"id": "C0017110",
"name": "gas",
"pos": [
107,
110
]
} |
similarity of the fatty acid pattern suggests that the free fatty acids are derived from the triacyl glycerols as in human sebum . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
18,
28
]
} | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
55,
71
]
} |
a retrospective analysis of refractive error among humans subjected to various ocular anomalies that disrupt pattern vision revealed a significant degree of myopia . | NA | {
"id": "C0034951",
"name": "refractive error",
"pos": [
28,
44
]
} | {
"id": "C0027092",
"name": "myopia",
"pos": [
157,
163
]
} |
epinephrine and norepinephrine significantly increased facility , approximately 25 % and 40 % , respectively , beyond the effect of mock aqueous in all three types of eyes . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
0,
11
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
16,
30
]
} |
the percentage increases in facility produced by epinephrine and norepinephrine were virtually identical in disinserted and nondisinserted eyes and were independent of starting facility in the individual eyes . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
49,
60
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
65,
79
]
} |
our results prove that the epinephrine- and norepinephrine-induced facility increase in cynomolgus eyes is not mediated by the iris or ciliary muscle and suggest that the increase in total facility is due largely to increased facility across the trabecular meshwork . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
27,
38
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
44,
58
]
} |
the conditional probabilities used in this model are the relative frequency of occurrence of 15 specific uroradiographic signs in the presence of cyst , tumor , and benign cortical nodule . | NA | {
"id": "C0010709",
"name": "cyst",
"pos": [
146,
150
]
} | {
"id": "C0027651",
"name": "tumor",
"pos": [
153,
158
]
} |
the escherichia coli endoribonuclease ribonuclease e , the enzyme responsible for the processing of precursor 5s ribosomal ribonucleic acid ( rna ) from the nascent ribosomal rna transcript , is thermolabile in rne-3071 mutants . | NA | {
"id": "C0035707",
"name": "5s ribosomal ribonucleic acid",
"pos": [
110,
139
]
} | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
165,
178
]
} |
adaptation of mycoplasma gallisepticum , a sterol-requiring mycoplasma sp. , to growth in a serum-free medium supplemented with cholesterol in decreasing concentrations and with various saturated or unsaturated fatty acids enabled us to control both the cholesterol levels and the membrane fatty acid composition . | NA | {
"id": "C0015690",
"name": "unsaturated fatty acids",
"pos": [
199,
222
]
} | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
290,
300
]
} |
lipid-phase transitions were observed in low-cholesterol-adapted organisms , whose membrane lipids were still highly ordered at the growth temperature . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
0,
5
]
} | {
"id": "C0025249",
"name": "membrane lipids",
"pos": [
83,
98
]
} |
glucose or pyruvate fermentation in the presence of acetone was correlated with increased substrate consumption , growth ( both rate and yield ) , acetate yield , and quantitative reduction of acetone to isopropanol in lieu of normal reduced fermentation products ( i.e. , h2 , ethanol , lactate ) . | NA | {
"id": "C0022237",
"name": "isopropanol",
"pos": [
204,
215
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
278,
285
]
} |
mycoplasma isozyme expression for seven of the enzymes were readily detected in various infected-cell culture lines by using either cell extracts or concentrated cell culture fluids . | NA | {
"id": "C0022173",
"name": "isozyme",
"pos": [
11,
18
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
47,
54
]
} |
this suggested that developmental 5s to 16s rna was more stable than vegetative cell 5s to 16s rna ( presumptive messenger rna ) . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
44,
47
]
} | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
113,
126
]
} |
the protein is similar to the surface protein alpha of acinetobacter ssp . in molecular weight , reassociation characteristics , and high ratio of acidic to basic amino acids . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
4,
11
]
} | {
"id": "C0025252",
"name": "surface protein",
"pos": [
30,
45
]
} |
the relative stability of membrane proteins in escherichia coli was investigated to determine whether these proteins are degraded at heterogeneous rates and , if so , whether the degradative rates are correlated with the sizes or charges of the proteins . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
26,
43
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
245,
253
]
} |
in contrast to the relationships found for soluble proteins in mammalian cells , there were no strong correlations between the degradative rates and either the isoelectric points or the molecular weights of membrane proteins in e. coli . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
51,
59
]
} | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
207,
224
]
} |
amino acids present in the walls consisted of glycine , glutamic acid , diaminopimelic acid , and alanine , in a molar ratio of approximately 1:1:1:0.6 -- 0.8 . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
0,
11
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
46,
53
]
} |
amino acids present in the walls consisted of glycine , glutamic acid , diaminopimelic acid , and alanine , in a molar ratio of approximately 1:1:1:0.6 -- 0.8 . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
0,
11
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
98,
105
]
} |
second , when polyadenylic acid-containing ribonucleic acid was extracted from polysomes from uninduced and induced cells and placed into a messenger ribonucleic acid-dependent in vitro translation system , nadp-gdh subunits were synthesized from the ribonucleic acid from both sources . | NA | {
"id": "C0035696",
"name": "messenger ribonucleic acid",
"pos": [
140,
166
]
} | {
"id": "C0035668",
"name": "ribonucleic acid",
"pos": [
251,
267
]
} |
when the salts were tested for their ability to dislodge cell-bound tritiated lysozyme , the extent of the initial release of enzyme by individual anions correlated with the anion potency for deoxyribonucleic acid liberation ( scn- greater than clo4- greater than i- greater than br- greater than no3- greater than cl- greater than f- ) , although the total amount of lysozyme dislodged did not correspond directly with cell lysis . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
147,
152
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
428,
429
]
} |
when the salts were tested for their ability to dislodge cell-bound tritiated lysozyme , the extent of the initial release of enzyme by individual anions correlated with the anion potency for deoxyribonucleic acid liberation ( scn- greater than clo4- greater than i- greater than br- greater than no3- greater than cl- greater than f- ) , although the total amount of lysozyme dislodged did not correspond directly with cell lysis . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
147,
152
]
} | {
"id": "C0016327",
"name": "f",
"pos": [
366,
367
]
} |
differences in the effectiveness of anions ( scn- , hco3- , cl- and f- ) in potentiating cell lysis could be enhanced or minimized by varying the lysozyme , anion , and bacterial cell concentrations . | NA | {
"id": "C0016327",
"name": "f",
"pos": [
2,
3
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
157,
162
]
} |
furthermore , on analyzing glycosaminoglycans and glycopeptides from the enzyme-treated cells and control cells , it was concluded that heparan sulfate was exclusively present on the cell surface and accessible to the heparitinase whereas other cell surface complex carbohydrates remained intact . | NA | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
27,
45
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
136,
151
]
} |
the mobility of spin labels covalently bound to the ca2+-transport atpase ( atp phosphohydrolase [ ec 3.y.1.3 ] ) was studied by electron spin-resonance spectroscopy in purified atpase and reconstituted vesicles . | NA | {
"id": "C0001476",
"name": "ca2",
"pos": [
52,
55
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
178,
184
]
} |
Subsets and Splits
No saved queries yet
Save your SQL queries to embed, download, and access them later. Queries will appear here once saved.