text
stringlengths 57
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| relation
stringclasses 125
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dict |
|---|---|---|---|
by measuring the enzyme activity in the eluate , the amount of antibodies could be determined even in a serum sample which contained antibodies corresponding to as little as 0.01 % of the standard antisera . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
63,
73
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
197,
205
]
} |
hydrolysis of the total non-cellulosic 14c-polysaccharides from soybean cell wall with carbohydrate hydrolases of an aspergillus oryzae enzyme preparation yielded 14c-monosaccharides and [ 14c ] isoprimeverose ( 6-o-alpha-d-xylopyranosyl-d-glucopyranose ) in which all of the xylosyl residues of the xyloglucan were recovered . | NA | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
87,
99
]
} | {
"id": "C0026492",
"name": "monosaccharides",
"pos": [
167,
182
]
} |
hydrogen-tritium exchange and nuclear magnetic resonance titrations of the histidine residues in ribonuclease st and analysis of their microenvironment . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
0,
8
]
} | {
"id": "C0041119",
"name": "tritium",
"pos": [
9,
16
]
} |
the pka values of his-60 and his-91 were estimated by hydrogen-tritium exchange titration to be 8.0 and 6.3 , respectively , and these values were confirmed by 1h nmr titration . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
54,
62
]
} | {
"id": "C0041119",
"name": "tritium",
"pos": [
63,
70
]
} |
the pka for his-91 was shifted to the alkaline side in the presence of 3'-gmp , a competitive inhibitor , in the titration plots observed by both hydrogen-tritium exchange and 1h nmr spectroscopy . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
146,
154
]
} | {
"id": "C0041119",
"name": "tritium",
"pos": [
155,
162
]
} |
the ( na+ and k+ ) -stimulated adenosine triphosphatase ( na+ , k+ ) -atpase ) from canine kidney reconstituted into phospholipid vesicles showed an atp-dependent , ouabain-inhibited uptake of 22na+ in the absence of added k+ . | NA | {
"id": "C0001473",
"name": "adenosine triphosphatase",
"pos": [
31,
55
]
} | {
"id": "C0001479",
"name": "na",
"pos": [
195,
197
]
} |
when very low density lipoproteins , labeled endogenously with [ 3h ] cholesterol and with radioiodinated apolipoprotein e , are added to perfusates of isolated rat livers , the labeled cholesteryl esters and apolipoprotein e are removed from the perfusate rapidly and at the same rate . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
70,
81
]
} | {
"id": "C0008387",
"name": "cholesteryl esters",
"pos": [
186,
204
]
} |
using this clock , we postulate that the chromosomal segregation of human prl and human growth hormone occurred about 392 million years ago and that growth hormone and chorionic sommatomammotropin underwent an intrachromosomal recombination within the last 10 million years . | NA | {
"id": "C0169964",
"name": "human growth hormone",
"pos": [
82,
102
]
} | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
149,
163
]
} |
four different repeated sequence elements have been found in cloned silk moth dna , extending from 5700 base pairs upstream from the silk fibroin gene to 600 base pairs within its intervening sequence . | NA | {
"id": "C0074529",
"name": "silk",
"pos": [
68,
72
]
} | {
"id": "C0016042",
"name": "fibroin",
"pos": [
138,
145
]
} |
the data show that repeated sequences comprise a major portion of the dna flanking this developmentally regulated gene but not the dna immediately 5 ' to it ; | NA | {
"id": "C0000702",
"name": "a",
"pos": [
5,
6
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
131,
134
]
} |
we have recently developed an in vitro dna synthesis system in which a synthetic heptaribonucleotide pairs with a unique site on a single-stranded fd dna molecule and thereby primes the growth of new dna strands from this single point ( huang , c.-c. , and hearst , j. e. ( 1980 ) anal . biochem . 103 , 127-139 ) . | NA | {
"id": "C0012935",
"name": "single-stranded",
"pos": [
131,
146
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
200,
203
]
} |
their phospholipid and cholesterol contents have been determined , and the cholesterol/phospholipid ratios of the two surface fractions are over twice that of the intracellular membrane , which also has a significantly lower microviscosity as determined by fluorescence polarization using diphenyl hexatriene . | NA | {
"id": "C0031676",
"name": "phospholipid",
"pos": [
6,
18
]
} | {
"id": "C0771648",
"name": "phospholipid",
"pos": [
87,
99
]
} |
the aim of this investigation was to find a nucleophile that would displace a methyl group from the sulfonium cation of [ s- [ 13c ] methylmethionine-192 ] -alpha-chymotrypsin without disrupting the five disulfide bridges of the protein , thereby producing [ [ epsilon-13c ] methionine-192 ] -alpha-chymotrypsin , an isotopically enriched version of the native enzyme desirable for 13c nmr studies . | NA | {
"id": "C0042889",
"name": "methylmethionine",
"pos": [
133,
149
]
} | {
"id": "C0025646",
"name": "methionine",
"pos": [
275,
285
]
} |
upon repeating the experiment with [ s- [ 13c ] methylmethionine-192 ] -alpha chymotrypsin , we isolated in 40 % yield a protein which was identified as [ [ epsilon-13c ] methionine-192 ] -alpha-chymotrypsin by a combination of 13c nmr and chemical criteria . | NA | {
"id": "C0042889",
"name": "methylmethionine",
"pos": [
48,
64
]
} | {
"id": "C0025646",
"name": "methionine",
"pos": [
171,
181
]
} |
d-amino acid transaminase from bacillus sphaericus shows a deuterium kinetic isotope effect ( vh/vd ) between 2 and 3 in the transamination of alpha-protio- or alpha-deuterio-d-alanine and alpha-ketoglutarate , suggesting that alpha-proton abstraction is at least partially rate-limiting for this reaction . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
2,
12
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
177,
184
]
} |
analysis of the products of deaminative cleavage of heparan sulfate by nitrous acid under conditions where cleavage occurs quantitatively at n-sulfated glucosamine residues showed that , although heparan sulfate from the three cell lines gave similar yields of o-sulfated disaccharides , both 215csc and 219ct had only about half as many o-sulfate residues in higher molecular weight oligosaccharides compared to heparan sulfate from 210c . | NA | {
"id": "C0012611",
"name": "disaccharides",
"pos": [
272,
285
]
} | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
384,
400
]
} |
subsequent analysis of solubilized membrane proteins by two-dimensional isoelectric focusing-polyacrylamide gel electrophoresis indicated cross-linking between radioactive phospholipids and an number of proteins . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
35,
52
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
203,
211
]
} |
if a fracture is suspected , a cross-table lateral radiograph should be made in an attempt to detect fat within the joint fluid and confirm the existence of an intra-articular fracture . | NA | {
"id": "C0016658",
"name": "fracture",
"pos": [
5,
13
]
} | {
"id": "C0332715",
"name": "intra-articular fracture",
"pos": [
160,
184
]
} |
their increased formation in response to fracture and pinning may stimulate the vascular changes , bone resorption and the proliferation of osteogenic cells observed after trauma to bone . | NA | {
"id": "C0016658",
"name": "fracture",
"pos": [
41,
49
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
172,
178
]
} |
we identified approximately 130 cellular proteins by fluorography of one-dimensional polyacrylamide electrophoretic gels and found that slightly less than half of them ( designated np , for nuclear proteins ) are almost exclusively nuclear . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
41,
49
]
} | {
"id": "C0028589",
"name": "nuclear",
"pos": [
232,
239
]
} |
cat superior cervical ganglia ( scg ) , denervated preganglionically 6-8 d previously , were stained for acetylcholinesterase ( ache ) and butyrylcholinesterase ( buche ) by the bis- ( thioacetoxy ) aurate ( i ) , or au ( ta ) 2 , method and compared by electron microscopy with normal scg described previously ( davis , r. , and g . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
105,
125
]
} | {
"id": "C0008429",
"name": "butyrylcholinesterase",
"pos": [
139,
160
]
} |
as in the normal scg , physostigmine-resistant staining , caused by noncholinesterase enzymes plus the possible presence of very low concentrations of ache or buche , was noted at external mitochondrial membranes , elements of the endoplasmic reticulum of neurites and schwann cells , and also in lysosomes . | NA | {
"id": "C0001044",
"name": "ache",
"pos": [
151,
155
]
} | {
"id": "C0008429",
"name": "buche",
"pos": [
159,
164
]
} |
in addition to ra , other retinoids , such as 13-cis-retinoic acid , retinyl acetate , the tmmp analog of ra and the phenyl analog of ra , but not the pyridyl analog of ra or retinyl palmitate , also inhibited cell growth and enhanced melanin synthesis . | NA | {
"id": "C0035339",
"name": "retinoids",
"pos": [
26,
35
]
} | {
"id": "C0022265",
"name": "13-cis-retinoic acid",
"pos": [
46,
66
]
} |
as the na+ channel may actually be a general uptake system for monovalent cations ( a number of cations inhibit na+ uptake ) , the uptake of these inhibitory cations was examined in amr2 cells . | NA | {
"id": "C0007449",
"name": "monovalent cations",
"pos": [
63,
81
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
158,
165
]
} |
in contrast , pro+ cells are as sensitive as , or in some cases slightly more sensitive than , pro- cells to glycine , basic amino acids , and to amino acids that are mainly transported by the l system . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
109,
116
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
146,
157
]
} |
in contrast , pro+ cells are as sensitive as , or in some cases slightly more sensitive than , pro- cells to glycine , basic amino acids , and to amino acids that are mainly transported by the l system . | NA | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
119,
136
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
146,
157
]
} |
when medium containing either hgh or sm-c was changed frequently so as to remove factors secreted by fibroblasts only those cells exposed to exogeneous somatomedin-c entered dna synthesis . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
101,
112
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
124,
129
]
} |
radioisotopic uptake studies with the glucose analogues 2-deoxy-d-glucose , and 3-o-methyl-d-glucose , and the nonmetabolizable stereoisomer l-glucose , indicated the presence of a saturable , stereospecific hexose carrier mechanism in both cell types . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
38,
45
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
208,
214
]
} |
tumor-promoting phorbol esters , such as 12-0-tetradecanoylphorbol-13-acetate ( tpa ) , stimulate mouse peritoneal exudate macrophages to undergo dna synthesis without added macrophage growth factor ( mgf ) . | NA | {
"id": "C0031586",
"name": "phorbol esters",
"pos": [
16,
30
]
} | {
"id": "C0039654",
"name": "tetradecanoylphorbol",
"pos": [
46,
66
]
} |
plasminogen activator ( pa ) levels of both exudate and resident peritoneal macrophages are elevated by tpa . | NA | {
"id": "C0032144",
"name": "plasminogen activator",
"pos": [
0,
21
]
} | {
"id": "C0032143",
"name": "tpa",
"pos": [
104,
107
]
} |
report on a case of intestinal obstruction due to a sigmoido-rectal and afterwards anal intussusception of a malignant tumor : review of the literature . | NA | {
"id": "C0021843",
"name": "of intestinal obstruction",
"pos": [
17,
42
]
} | {
"id": "C0021933",
"name": "intussusception",
"pos": [
88,
103
]
} |
reversed-phase and reversed-phase ion-pair chromatographic methods were used to determine 5-alkyluracils in the presence of purine bases ( mainly adenine ) in the hydrolysates of enzymatically synthesized dna . | NA | {
"id": "C0034140",
"name": "purine",
"pos": [
124,
130
]
} | {
"id": "C0001407",
"name": "adenine",
"pos": [
146,
153
]
} |
a new method for quantitating cannabidiol ( cbd ) and delta 9-tetrahydrocannabinol ( thc ) in mouse plasma and brain involves ( 1 ) the separation of cbd and thc from their major metabolites by the use of isocratic , reversed-phase high-performance liquid chromatography ( hplc ) , and ( 2 ) the on-line reaction of the cannabinoids with fast blue salt b ( fbb ) as a the former elute from the column ; | NA | {
"id": "C0039663",
"name": "thc",
"pos": [
85,
88
]
} | {
"id": "C0006864",
"name": "cannabinoids",
"pos": [
320,
332
]
} |
in addition to this hplc -- fbb analytical procedure , a method for extracting cbd and thc from brain and plasma is described , and selected examples illustrate the procedure 's application to the analysis of cbd and thc in mouse plasma and brain samples taken from animals injected with these two cannabinoids . | NA | {
"id": "C0039663",
"name": "thc",
"pos": [
87,
90
]
} | {
"id": "C0006864",
"name": "cannabinoids",
"pos": [
298,
310
]
} |
separation and semi-quantitative determination of tetracycline degradation products in tetracycline hydrochloride powders and capsules by thin-layer chromatography . | NA | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
50,
62
]
} | {
"id": "C0546879",
"name": "tetracycline hydrochloride",
"pos": [
87,
113
]
} |
the faster peak should not be proinsulin but an associated c-peptide without a covalent bond . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
30,
40
]
} | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
59,
68
]
} |
proinsulin is in fact eluted in the fraction prior to the faster eluting peak of c-peptide immunoreactivity with 1 m acetic acid as the eluting buffer . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
0,
10
]
} | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
81,
90
]
} |
therefore the use of gel chromatography to study c-peptide and proinsulin needs to be carefully re-evaluated , although the method has been established as one of the standard methods . | NA | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
49,
58
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
63,
73
]
} |
a rapid , sensitive and specific high-performance liquid chromatography ( hplc ) assay was developed for the determination of diazepam , and its major metabolites , oxazepam , temazepam and nordiazepam in plasma , blood , and urine of humans and cats . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
126,
134
]
} | {
"id": "C0011279",
"name": "nordiazepam",
"pos": [
190,
201
]
} |
the hplc assay was used to monitor the plasma concentration -- time profile in humans following a 10-mg oral dose of diazepam and the blood concentration time profile of diazepam and nordiazepam in cats following a 10 mg/kg intravenous dose of either diazepam or nordiazepam . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
117,
125
]
} | {
"id": "C0011279",
"name": "nordiazepam",
"pos": [
263,
274
]
} |
based upon the presence of appropriate biosynthetic enzyme markers and neuropeptide localization , these findings suggest that neurons within the area postrema contain noradrenalin and enkephalin and that the afferent axons contain substance p , adrenalin and , probably , noradrenalin . | NA | {
"id": "C0014563",
"name": "adrenalin",
"pos": [
171,
180
]
} | {
"id": "C0028351",
"name": "noradrenalin",
"pos": [
273,
285
]
} |
erythroplasia of queyrat ( eq ) is an epidermoid carcinoma in situ which is histologically identical with bowen 's disease of the skin but involves mucosal surfaces . | NA | {
"id": "C0007137",
"name": "epidermoid carcinoma",
"pos": [
38,
58
]
} | {
"id": "C0006079",
"name": "bowen 's disease of the skin",
"pos": [
106,
134
]
} |
( 3 ) fibroblastic studies suggested little or no phenylalanine hydroxylase activity in cells of patients with pku and controls ; | NA | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
6,
18
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
88,
93
]
} |
peripheral blood mononuclear cells from ragweed-sensitive individuals formed soluble factors that inhibited rosette formation of fc epsilon receptor ( + ) cells with ige-coated ox erythrocytes when the cells were incubated with ragweed antigen e and human ige . | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
0,
34
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
202,
207
]
} |
the cytotoxic activity was mediated by t lymphocytes of the cytotoxic/suppressor subset , as determined by cytofluorographic analysis and antibody plus complement-mediated lysis , using monoclonal antibodies to human lymphocyte surface antigen . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
138,
146
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
186,
207
]
} |
a panel of hybridoma antibodies was used to study the expression of the 2 major internal influenza a virus proteins , matrix protein ( m ) , and nucleoprotein ( np ) on the surface of influenza a-infected p815 cells . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
107,
114
]
} | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
145,
158
]
} |
an antiserum prepared by injecting ce mice with cba spleen cells has been shown to contain antibodies specifically reactive with nk cells . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
3,
12
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
91,
101
]
} |
to determine whether daily intraventricular injection of gentamicin sulfate would cause neurologic or morphologic abnormalities of the central nervous system , adult male rabbits were given gentamicin sulfate , 2 mg/kg , intramuscularly twice a day plus saline , 0.2 ml ( group 1 ) , or gentamicin , 0.05 mg/kg ( group 2 ) , 0.25 mg/kg ( group 3 ) , or 0.5 mg/kg ( group 4 ) , given as the sulfate intraventricularly once a day . | NA | {
"id": "C0546866",
"name": "gentamicin sulfate",
"pos": [
57,
75
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
287,
297
]
} |
this mutant was inhibited by `` '' tk-mediated '' '' drugs : idoxuridine , which is already in use , and two drugs with promising clinical potential , 1-beta-arabinofuranosylthymine and e-5- ( 2-bromovinyl ) -2'-deoxyuridine . | NA | {
"id": "C0020811",
"name": ": idoxuridi",
"pos": [
59,
70
]
} | {
"id": "C0011535",
"name": "'-deoxyuridi",
"pos": [
210,
222
]
} |
the absolute concentration of each fatty acid and the total nonesterified fatty acid concentration decreased exponentially with age and were significantly higher for girls than for boys . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
35,
45
]
} | {
"id": "C0015688",
"name": "nonesterified fatty acid",
"pos": [
60,
84
]
} |
the activity of epinephrine-sensitive adenylate cyclase of human fat cell ghosts is markedly enhanced by the gtp analog 5'-guanylyl-imidodiphosphate ( gmp-p ( nh ) p ) , but a similar effect of gtp itself has not been heretofore demonstrable . | NA | {
"id": "C0018366",
"name": "guanylyl-imidodiphosphate",
"pos": [
123,
148
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
194,
197
]
} |
since a-i , a-ii , and a-iv apoproteins are also integral components of lymph chylomicrons , we suggest that the protein be designated a-v apoprotein . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
31,
38
]
} | {
"id": "C0003601",
"name": "apoprotein",
"pos": [
139,
149
]
} |
no correlation was found between cholesterol esterifying activity in a ) the lumen or b ) the mucosa , and cholesteryl ester output into lymph . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
33,
44
]
} | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
107,
124
]
} |
ammonia gas : an improved reagent for chemical ionization mass spectrometry of bile acid methyl ester acetates . | NA | {
"id": "C0002607",
"name": "ammonia",
"pos": [
0,
7
]
} | {
"id": "C0017110",
"name": "gas",
"pos": [
8,
11
]
} |
kinetic modeling of the vldl-tg data suggested that the tg reduction was due to a decrease in tg content of vldl and hence a reduction in lipoprotein size more than number . | NA | {
"id": "C0023825",
"name": "vldl",
"pos": [
24,
28
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
138,
149
]
} |
rat ldl fractions ( d 1.02-1.05 g/ml ) , in contrast , were degraded more rapidly than human ldl by rat fibroblasts , caused a significant increase in cell cholesterol content , an increase in acat activity , and a significant decrease in hmg coa reductase activity . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
104,
115
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
151,
155
]
} |
the possible multiple role of cockroach dglp in transporting such lipids as diacylglycerol , cholesterol , and hydrocarbon from the site of storage , absorption , or synthesis is discussed . | NA | {
"id": "C0023820",
"name": "dglp",
"pos": [
40,
44
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
66,
72
]
} |
we describe the selective analysis of n-methylated ribonucleosides , i.e. , n1-methyl adenosine ( m1ado ) and n7-methyl guanosine ( m7guo ) in the presence of other nucleosides in urine . | NA | {
"id": "C0035546",
"name": "ribonucleosides",
"pos": [
51,
66
]
} | {
"id": "C0028621",
"name": "nucleosides",
"pos": [
165,
176
]
} |
fingertip trauma , whether a clean laceration or a crushing avulsion , may result in further injury , possible permanent disability , or in a functional well-healed finger . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
10,
16
]
} | {
"id": "C0043246",
"name": "laceration",
"pos": [
35,
45
]
} |
children tended to impinge on younger children more frequently than older children ( p less than .06 ) . | NA | {
"id": "C0008059",
"name": "children",
"pos": [
0,
8
]
} | {
"id": "C1455726",
"name": "older children",
"pos": [
68,
82
]
} |
titrations of the enzyme with cratp in the presence of na+ and k+ yielded characteristic enhancements for the binary enzyme-cratp and ternary enzyme-mg2+-cratp complexes of 3.3 and 3.6 and dissociation constants for cratp of 5 and 12 microm , respectively . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
18,
24
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
142,
148
]
} |
computed tomography fails to ascertain , or exclude , the presence of intracranial haemorrhage in a considerable number of cases , especially in subarachnoid haemorrhage and haemorrhagic infarcts . | NA | {
"id": "C0151699",
"name": "intracranial",
"pos": [
70,
82
]
} | {
"id": "C0038525",
"name": "subarachnoid",
"pos": [
145,
157
]
} |
serum concentrations of primidone and its metabolites-phenobarbitone and phenylethylmalonamide-were measured in 40 epileptic patients receiving treatment with primidone alone or primidone plus phenytoin . | NA | {
"id": "C0031412",
"name": "phenobarbitone",
"pos": [
54,
68
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
178,
187
]
} |
ala ( 2 g n/kg ) , gly /2 g n/kg ) , met ( 0.2 -- 0.4 g n/kg ) and cys ( 0.4 g n/kg ) were the only amino acids which increased all five activities . | NA | {
"id": "C0017890",
"name": "gly",
"pos": [
19,
22
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
100,
111
]
} |
the keto-acid of alanine , pyruvate , or the alpha-hydroxy acid of methionine did not increase any enzyme whereas the same molar dose of their amino acids increased all five activities . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
17,
24
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
143,
154
]
} |
thus three amino acids of casein , ala , gly and especially met , account for the enzyme adaptation of the urea cycle on a high casein diet . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
11,
22
]
} | {
"id": "C0017890",
"name": "gly",
"pos": [
41,
44
]
} |
a factorial experiment was conducted using two degrees of oxidation of the 7.5 % supplemental fish oil ( peroxide values of 5 and 120 meq/kg oil ) , two levels of supplemental dl-apha-tocopheryl acetate ( 0 and 33 mg/kg diet ) and two levels of ethoxyquin ( 0 and 125 mg/kg diet ) supplementation . | NA | {
"id": "C0016157",
"name": "fish oil",
"pos": [
94,
102
]
} | {
"id": "C0028908",
"name": "oil",
"pos": [
141,
144
]
} |
the latter received caffeine via drinking water ( 0.06 mg/ml h2o ) during a 4-week period whereas controls received water only . | NA | {
"id": "C0599638",
"name": "drinking water",
"pos": [
33,
47
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
116,
121
]
} |
all were tested before and after their dietary lipid was changed from corn oil to butter plus cholesterol . | NA | {
"id": "C0012171",
"name": "dietary lipid",
"pos": [
39,
52
]
} | {
"id": "C0006494",
"name": "butter",
"pos": [
82,
88
]
} |
although both types of changes in migration when considered together were statistically more frequent in the group of infertile women it was not possible to distinguish , on the basis of this test , between fertile and supposedly infertile individual women . | NA | {
"id": "C0021359",
"name": "infertile",
"pos": [
118,
127
]
} | {
"id": "C0021361",
"name": "infertile",
"pos": [
230,
239
]
} |
it appears that some of the clinical signs and symptoms seen in these patients ( including toxemia , theca lutein cyst , hyperthyroidism and thyrotoxicosis , and galactorrhea ) are a direct manifestation or reflection of the level of hcg . | NA | {
"id": "C0020550",
"name": "hyperthyroidism",
"pos": [
121,
136
]
} | {
"id": "C0040156",
"name": "thyrotoxicosis",
"pos": [
141,
155
]
} |
a 28 yr old white woman with fevers , arthralgias , and panniculitis was found to have factitial weber-christian disease induced by repeated subcutaneous injections of paint . | NA | {
"id": "C0030326",
"name": "panniculitis",
"pos": [
56,
68
]
} | {
"id": "C0030328",
"name": "weber-christian disease",
"pos": [
97,
120
]
} |
we have recently described that human autologous rosette-forming ( tar ) cells have the characteristics of postthymic precursor cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
73,
78
]
} | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
118,
133
]
} |
pretreatment of peripheral blood mononuclear cells ( mnc ) from sle patients with serum from young normal adults or wtih serum thymic factors ( fts ) increased their percentages of tar cells significantly but reached near normal values in only 3 patients with inactive disease . | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
16,
50
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
185,
190
]
} |
characteristic functions of postthymic precursor cells are feedback inhibition and generation of suppressor cells which we studied in systems where we depleted or added tar cells to tmu and b cells , or mnc , respectively , using as indicators the production of immunoglobulins measured in culture supernatants or 3h-thymidine incorporation . | NA | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
39,
54
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
192,
197
]
} |
pulmonary alveolar proteinosis ( pap ) is a diffuse pulmonary disease of unknown etiology , characterized by the accumulation of large amounts of amorphous phospholipid containing material in the alveolar spaces . | NA | {
"id": "C0034050",
"name": "pap",
"pos": [
33,
36
]
} | {
"id": "C0024115",
"name": "pulmonary disease",
"pos": [
52,
69
]
} |
among a number of salts and ions tested for effectiveness in causing ca2+ release the order was gluconate- less than cacodylate- less than isethionate- = methane sulfonate- less than methylsulfate- less than scn- for anions , and k+ = na+ = li+ less than choline+ = tetramethylammonium+ for cations . | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
28,
32
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
217,
223
]
} |
among a number of salts and ions tested for effectiveness in causing ca2+ release the order was gluconate- less than cacodylate- less than isethionate- = methane sulfonate- less than methylsulfate- less than scn- for anions , and k+ = na+ = li+ less than choline+ = tetramethylammonium+ for cations . | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
28,
32
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
291,
298
]
} |
k+-sensitive liquid ion exchange electrode systems respond with a slow potential change to acetylcholine , choline , anticholinergic drugs , biogenic amines , and glutamic acid . | NA | {
"id": "C0001041",
"name": "acetylcholine",
"pos": [
91,
104
]
} | {
"id": "C0005496",
"name": "biogenic amines",
"pos": [
141,
156
]
} |
the septic state is characterized in both the basal and amino acid infusion state by splanchnic extraction of an unbalanced mixture of amino acids which is deficient in branched-chain amino acids and in relative excess of glucogenic amino acids with increased glucose release and increased utilization of amino acids for gluconeogenesis . | NA | {
"id": "C0002521",
"name": "branched-chain amino acids",
"pos": [
169,
195
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
305,
316
]
} |
the data suggest that the patient in late sepsis should have a branched-chain rich amino acid mixture and that the hepatic failure of sepsis is strongly associated with peripheral release of an unbalanced mixture of amino acids secondary to enhanced branched-chain catabolism . | NA | {
"id": "C0002521",
"name": "branched-chain",
"pos": [
63,
77
]
} | {
"id": "C0002520",
"name": "amino",
"pos": [
216,
221
]
} |
to determine whether multiple priming events are a general property of retroviral dna synthesis in vivo , we also examined plus strands of mouse mammary tumor virus dna in chronically infected rat cells after induction of rna and subsequent dna synthesis with dexamethasone . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
45,
46
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
241,
244
]
} |
label incorporated in viral rf dna in vivo appeared first in ri dna and then in single-stranded dna during incubation in vitro . | NA | {
"id": "C0012939",
"name": "viral",
"pos": [
22,
27
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
96,
99
]
} |
in addition to three rna species cosedimenting with the three viral rna segments l ( 29s ) , m ( 23s ) , and s ( 17s ) , a fourth major rna species , sedimenting at about 12s ( s2 ) , was found early in the infection . | NA | {
"id": "C0035736",
"name": "viral rna",
"pos": [
62,
71
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
136,
139
]
} |
5-bromodeoxyuridine-labeled viral dna ( hh ) recovered by banding on cesium chloride gradients was sedimented on neutral sucrose density gradients or separated by the agarose gel-dna transfer procedure and detected by hybridization with complementary dna . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
28,
37
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
251,
254
]
} |
levels of the two species of closed circular viral dna made in fv-1 permissive cells increased relative to the levels of linear dna during the chase period . | NA | {
"id": "C0012925",
"name": "circular",
"pos": [
36,
44
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
128,
131
]
} |
to determine whether the transport of linear viral dna from the cytoplasm into the nucleus was prevented by the fv-1 gene product , sim.r cells were fractionated into cytoplasmic and nuclear fractions , and viral dna was detected in each fraction by the agarose gel-dna transfer procedure . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
45,
54
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
266,
269
]
} |
( i ) fragments near the ends of hvp dna were identified by treating viral dna with lambda exonuclease before restriction enzyme digestion ; | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
37,
40
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
69,
78
]
} |
these experiments indicate that each avian sarcoma virus infection of a chicken embryo fibroblast requires division of the infected cell for production of that virus regardless of whether or not the cell is already producing a similar virus . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
87,
97
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
199,
203
]
} |
a circular map of the phi 11 dna was established , and the phage genome was circularly permuted based on the failure to end label mature viral dna , restriction maps of replicating dna , and finally , homoduplex analysis in the electron microscope . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
181,
184
]
} |
a circular map of the phi 11 dna was established , and the phage genome was circularly permuted based on the failure to end label mature viral dna , restriction maps of replicating dna , and finally , homoduplex analysis in the electron microscope . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
137,
146
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
181,
184
]
} |
a restriction enzyme map of the prophage form of phi 11 dna was obtained by analysis of chromosomal dna from a lysogenic strain . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
100,
103
]
} |
a microscopical study of the av conduction system using a serial sectioning method , was performed on 81 autopsied hearts with blocks anywhere in the hearts without arrhythmia . | NA | {
"id": "C0018794",
"name": "blocks",
"pos": [
127,
133
]
} | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
165,
175
]
} |
hypertrophy anywhere in the av conduction system was seen in 77 % , 42 % , 78 % , 39 % , 30 % and 74 % of the cases with blocks , sick sinus syndrome , pre-excitation syndrome , other arrhythmias , normal hearts and hypertrophied hearts without arrhythmia , respectively . | NA | {
"id": "C0032915",
"name": "pre-excitation syndrome",
"pos": [
152,
175
]
} | {
"id": "C0003811",
"name": "hearts",
"pos": [
230,
236
]
} |
his arrhythmia is characterized by incessant form of tachycardia which is not initiated by a triggering extrasystole but by critical shortening of p-p interval . | NA | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
4,
14
]
} | {
"id": "C0340464",
"name": "extrasystole",
"pos": [
104,
116
]
} |
the authors discuss the information on the prevalence of the various forms of ischemic heart disease , the frequency of the risk factors among them , the patients ' knowledge of the fact that they have ischemic heart disease and application for medical aid , and the frequency of angina pectoris attacks in patients with myocardial infarction and in persons not suffering from this disease . | NA | {
"id": "C0151744",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0027051",
"name": "myocardial infarction",
"pos": [
321,
342
]
} |
[ four benzamides ( metoclopramide , sulpiride , sultopride and tiapride ) effects on the oestrus cycle of the female rat : a comparative statistical study ( author 's transl ) ] . | NA | {
"id": "C0005029",
"name": "benzamides",
"pos": [
7,
17
]
} | {
"id": "C0025853",
"name": "metoclopramide",
"pos": [
20,
34
]
} |
[ four benzamides ( metoclopramide , sulpiride , sultopride and tiapride ) effects on the oestrus cycle of the female rat : a comparative statistical study ( author 's transl ) ] . | NA | {
"id": "C0005029",
"name": "benzamides",
"pos": [
7,
17
]
} | {
"id": "C0038803",
"name": "sulpiride",
"pos": [
37,
46
]
} |
presence of dietary lipids generally gives a moderate increase of these parameters , but the effect of fish oil is higher than of other fats . | NA | {
"id": "C0012171",
"name": "dietary lipids",
"pos": [
12,
26
]
} | {
"id": "C0015677",
"name": "fats",
"pos": [
136,
140
]
} |
we recommend a staged treatment plan consisting of preliminary systemic -- pulmonary artery shunting for symptomatic children under 4 to 5 years of age and total correction for older children . | NA | {
"id": "C0008059",
"name": "children",
"pos": [
117,
125
]
} | {
"id": "C1455726",
"name": "older children",
"pos": [
177,
191
]
} |
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