text
stringlengths 57
1.72k
| relation
stringclasses 125
values | h
dict | t
dict |
|---|---|---|---|
alb , cp and tf are carrier proteins , at is a protease inhibitor , and agps are acute phase reactants , with protective functions in inflammation . | NA | {
"id": "C0007841",
"name": "cp",
"pos": [
6,
8
]
} | {
"id": "C0001347",
"name": "acute phase reactants",
"pos": [
81,
102
]
} |
alb , cp and tf are carrier proteins , at is a protease inhibitor , and agps are acute phase reactants , with protective functions in inflammation . | NA | {
"id": "C0040679",
"name": "tf",
"pos": [
13,
15
]
} | {
"id": "C0001347",
"name": "acute phase reactants",
"pos": [
81,
102
]
} |
review of the literature on pregnancy in epileptic women shows that a third to half experienced more seizures during gestation . | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
41,
50
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
101,
109
]
} |
it was found that the reaction with 2,5-dinitrophenol ( 2,5-dnp ) in dimethylsulfoxide ( dmso ) providing the highest batochromic shift in the electron spectra was most suitable . | NA | {
"id": "C0012466",
"name": "dinitrophenol",
"pos": [
40,
53
]
} | {
"id": "C0045511",
"name": "dnp",
"pos": [
60,
63
]
} |
it was found that rubomycin in equal with carminomycin doses by the toxicity induced more significant and slower reducing shifts in the immune response . | NA | {
"id": "C0011015",
"name": "rubomycin",
"pos": [
18,
27
]
} | {
"id": "C0007308",
"name": "carminomycin",
"pos": [
42,
54
]
} |
analysis of the cell mechanism of the immunosuppressive effects of rubomycin and carminomycin at early periods after their administration showed that the antibiotics inhibited mainly the functional activity of b-lymphocytes and had not effect on the helper function of t-lymphocytes . | NA | {
"id": "C0011015",
"name": "rubomycin",
"pos": [
67,
76
]
} | {
"id": "C0007308",
"name": "carminomycin",
"pos": [
81,
93
]
} |
high nephrotoxicity of sisomycin as compared to that of gentamicin , kanamycin or streptomycin under conditions of their equal levels in the blood was revealed on the basis of the above correlation . | NA | {
"id": "C0037209",
"name": "sisomycin",
"pos": [
23,
32
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
56,
66
]
} |
still , when the antibiotic concentrations in the blood serum were maintained at the respective therapeutic levels , the nephrotoxic effects of sisomycin and gentamicin were almost equal . | NA | {
"id": "C0037209",
"name": "sisomycin",
"pos": [
144,
153
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
158,
168
]
} |
the safe concentration of gentamicin in blood serum is 8 micrograms/ml , while that of sisomycin in 6 micrograms/ml . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
26,
36
]
} | {
"id": "C0037209",
"name": "sisomycin",
"pos": [
87,
96
]
} |
high-boiling coal tar acids ( phenols ) , vitamin a ( retinyl acetate ) , and hydrocortisone butyrate ( locoid ) were assayed . | NA | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
42,
51
]
} | {
"id": "C0073109",
"name": "retinyl acetate",
"pos": [
54,
69
]
} |
findings included : genu varum , shortened stature , fasting hypophosphataemia ( 2.3-2.5 mg/100 ml ; 0.74-0.81 mmol/l ) , diminished theoretical renal threshold for phosphate ( tmp/gfr ) , and osteomalacia without rickets . | NA | {
"id": "C0029442",
"name": "osteomalacia",
"pos": [
193,
205
]
} | {
"id": "C0035579",
"name": "rickets",
"pos": [
214,
221
]
} |
a double-blind , controlled trial was performed to assess the effect of a short intraoperative course of cefoxitin , a new broad spectrum cephamycin antibiotic , on the incidence of septic complications following elective colonic and rectal surgery . | NA | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
105,
114
]
} | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
138,
148
]
} |
in a retrospective study involving 400 patients , we found that this step did not increase postoperative bleeding as measured by drainage from the chest tube and by the need to return patients to the operating room because of bleeding . | NA | {
"id": "C0032788",
"name": "postoperative bleeding",
"pos": [
91,
113
]
} | {
"id": "C0019080",
"name": "bleeding",
"pos": [
226,
234
]
} |
these contractile fibroblasts share characteristics of both smooth muscle cells and fibroblasts and are thought to be the cellular cause of wound and scar contraction . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
18,
29
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
122,
130
]
} |
in young adults , fsh pretreatment resulted in increased levels of androstenedione , testosterone , and 5 alpha dihydrotestosterone , but not progesterone , 17 hydroxyprogesterone , or estradiol . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
142,
154
]
} | {
"id": "C0020387",
"name": "17 hydroxyprogesterone",
"pos": [
157,
179
]
} |
hypersensitivity pneumonitis due to pigeon 's exposure ( pigeon 's breeder disease ) is a interstitial lung disease caused by immune mechanisms after sensitization to pigeon serum antigens . | NA | {
"id": "C0002390",
"name": "hypersensitivity pneumonitis",
"pos": [
0,
28
]
} | {
"id": "C0206062",
"name": "interstitial lung disease",
"pos": [
90,
115
]
} |
because daily ingestion of 592 ml of table wine ( 12 % ethanol by volume ) during mealtime had no notable effect on long-term , `` '' therapeutic '' '' hypoprothrombinemia with racemic warfarin sodium in normal subjects , similar experiments were repeated using fortified wine ( 20 % ethanol by volume ) during fasting . | NA | {
"id": "C0043188",
"name": "wine",
"pos": [
43,
47
]
} | {
"id": "C0001962",
"name": "% ethan",
"pos": [
282,
289
]
} |
none of the primary and methylated amines tested ( i.e . methylamine , dimethylamine , trimethylamine , tetramethylammonium chloride , choline , ethylamine , propylamine , butylamine and benzylamine ) were utilized as a carbon and energy source , although the majority of yeasts ( 86 % ) were able to utilize one or more of these compounds as a nitrogen source . | NA | {
"id": "C0002508",
"name": "amines",
"pos": [
35,
41
]
} | {
"id": "C0033504",
"name": "propylamine",
"pos": [
158,
169
]
} |
the present report examines four such events-parental death , parental divorce , sibling death , and having been the youngest child for less than two years-for their frequency of occurrence within four groups of physician subjects classified according to current health status as follows : major cancer , skin cancer , benign tumor , and healthy controls . | NA | {
"id": "C0524342",
"name": "parental",
"pos": [
45,
53
]
} | {
"id": "C0011065",
"name": "death",
"pos": [
89,
94
]
} |
the defective cell in both pseudoxanthoma and some of the extracolonic manifestations of gardner 's syndrome is the fibroblast ; | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
116,
126
]
} |
two case-control studies of motor neuron disease that involved 712 cases and 158 cases , respectively , showed that ( 1 ) mechanical injuries were two to three times more frequent in both sexes , heralding amyotrophic lateral sclerosis , progressive bulbar paralysis , and progressive muscular atrophy ; | NA | {
"id": "C0085084",
"name": "motor neuron disease",
"pos": [
28,
48
]
} | {
"id": "C0002736",
"name": "amyotrophic lateral sclerosis",
"pos": [
206,
235
]
} |
two case-control studies of motor neuron disease that involved 712 cases and 158 cases , respectively , showed that ( 1 ) mechanical injuries were two to three times more frequent in both sexes , heralding amyotrophic lateral sclerosis , progressive bulbar paralysis , and progressive muscular atrophy ; | NA | {
"id": "C0085084",
"name": "motor neuron disease",
"pos": [
28,
48
]
} | {
"id": "C0030442",
"name": "progressive bulbar paralysis",
"pos": [
238,
266
]
} |
urinary excretion of electrolytes , creatinine , urea , and antidiuretic hormone -- measured as arginine vasopressin ( avp ) by radioimmunoassay -- was investigated in eight himalayan mountaineers during ascent on foot from 1900- 5400 m . | NA | {
"id": "C0042413",
"name": "antidiuretic",
"pos": [
60,
72
]
} | {
"id": "C0003779",
"name": "arginine vasopressin",
"pos": [
96,
116
]
} |
monophasic binding curves were produced by penicillin g , penicillin v , propicillin , mezlocillin , azlocillin , carbenicillin , ticarcillin and mecillinam . | NA | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
43,
55
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
114,
127
]
} |
it also enhances the head-twitch effect of 5-hydroxy-tryptophan , the effects of noradrenaline , adrenaline , serotonin , tyramine on blood pressure as well as the hypertensive and tremor activities of tryptamine . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
81,
94
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
97,
107
]
} |
1 factors influencing steady-state plasma concentrations of diazepam ( dz ) and its major metabolite desmethyldiazepam ( dmdz ) were assessed in 110 male veterans administration outpatient clinic patients ( mean age 53 years ) . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
60,
68
]
} | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
101,
118
]
} |
3 steady-state plasma concentrations of dz ( mean 329 ng/ml ) and dmdz ( mean 389 ng/ml ) were highly correlated ( r = 0.80 ) , with a mean dmdz/dz ratio of 1.26 . | NA | {
"id": "C0011279",
"name": "dmdz",
"pos": [
66,
70
]
} | {
"id": "C0012010",
"name": "dz",
"pos": [
145,
147
]
} |
4 weight-corrected daily dose were significantly correlated with plasma level of dz ( r = 0.32 ) , dmdz ( r = 0.38 ) and the sum of dz plus dmdz ( r = 0.37 ) , but explained a small fraction of individual variation . | NA | {
"id": "C0012010",
"name": "dz",
"pos": [
81,
83
]
} | {
"id": "C0011279",
"name": "dmdz",
"pos": [
140,
144
]
} |
2 the effect of both drugs on blood pressure , plasma noradrenaline ( na ) , plasma adrenaline ( ad ) , urinary catecholamines and plasma renin activity ( pra ) was assessed in four previously untreated male hypertensive patients in a cross over study . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
54,
67
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
84,
94
]
} |
5 during withdrawal of either drug there was rebound of blood pressure and na , ad , pra , overshooting baseline levels . | NA | {
"id": "C0028351",
"name": "na",
"pos": [
75,
77
]
} | {
"id": "C0014563",
"name": "ad",
"pos": [
80,
82
]
} |
2 this method has been used to establish dose-response curves for the constrictor effects of noradrenaline , adrenaline , 5-hydroxytryptamine and dihydroergotamine after direct local infusion . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
93,
106
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
109,
119
]
} |
3 the degree of conjugation of mestranol and levonorgestrel was much lower than for ethinyloestradiol suggesting that the 17-position of the steroid nucleus is relatively inaccessible for conjugation . | NA | {
"id": "C0025506",
"name": "mestranol",
"pos": [
31,
40
]
} | {
"id": "C0015011",
"name": "ethinyloestradiol",
"pos": [
84,
101
]
} |
morphometric analysis of lymphoid cells in the skin was used to differentiate between cutaneous t cell lymphomas ( ctcl ) , i.e . mycosis fungoides ( mf ) and sezary syndrome ( ss ) , and chronic benign skin diseases . | NA | {
"id": "C0079773",
"name": "cutaneous t cell lymphomas",
"pos": [
86,
112
]
} | {
"id": "C0036920",
"name": "sezary syndrome",
"pos": [
159,
174
]
} |
the average diameter of ml was 0.5 microgram , and that of ul was 0.08 microgram . | NA | {
"id": "C0023828",
"name": "ml",
"pos": [
24,
26
]
} | {
"id": "C1721091",
"name": "ul",
"pos": [
59,
61
]
} |
de novo synthesis of factor viii related protein ( viii : r ) was quantitated by incorporation of labelled amino acids into specific protein subunits . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
41,
48
]
} | {
"id": "C0599220",
"name": "protein subunits",
"pos": [
133,
149
]
} |
it is suggested that the abnormal results of tryptophan load tests in women receiving oestrogens are the result of inhibition of kynureninase by oestrogen conjugates , and that there is no evidence for oestrogen-induced vitamin b deficiency in such cases . | NA | {
"id": "C0014938",
"name": "oestrogen conjugates",
"pos": [
145,
165
]
} | {
"id": "C0014939",
"name": "oestrogen",
"pos": [
202,
211
]
} |
retention of arginine , proline and glycine in the body was greater than the apparent absorption of each of these amino acids . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
36,
43
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
114,
125
]
} |
both the membrane-bound and the soluble forms of the enzyme are inhibited by modifiers of thiols [ n-ethylmaleimide ( nem ) and p- ( chloromercuri ) phenylsulfonate ( pcms ) ] , vicinal dithiols [ phenylarsine oxide and diazenedicarboxylic acid bis ( dimethylamide ) ( diamide ) ] , and disulfides ( sulfite , sulfide , and cyanide ) . | NA | {
"id": "C0012771",
"name": "disulfides",
"pos": [
287,
297
]
} | {
"id": "C0038739",
"name": "sulfide",
"pos": [
310,
317
]
} |
fluoride competitively inhibits the catalytic activity of the enzyme and appears in a ternary enzyme-reduced nicotinamide adenine dinucleotide ( nadh ) -fluoride complex detectable in fluorescence and circular dichroism measurements . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
62,
68
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
94,
100
]
} |
dilution experiments showed that nadh binding in the presence of nacl is independent of enzyme concentration , demonstrating that the chloride sensitivity is not linked to reversible dissociation of the enzyme . | NA | {
"id": "C0037494",
"name": "nacl",
"pos": [
65,
69
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
134,
142
]
} |
titration with leucine showed that the reaction of butanedione also took place with the enzyme-nadh-alpha-ketoglutarate-leucine complex more slowly than with the free enzyme . | NA | {
"id": "C0026741",
"name": "enzyme",
"pos": [
88,
94
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
167,
173
]
} |
unlike the reaction of virions with phospholipid vesicle , nonspecific adherence of lipoproteins and exogenous lipids to the envelope of the virus was found to be minimal . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
84,
96
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
111,
117
]
} |
correct codon -- anticodon base pairing at the 5'-anticodon position blocks covalent cross-linking between transfer ribonucleic acid and 16s rna at the ribosomal p site . | NA | {
"id": "C0003284",
"name": "anticodon",
"pos": [
17,
26
]
} | {
"id": "C0035711",
"name": "transfer ribonucleic acid",
"pos": [
107,
132
]
} |
the computed contribution to the stabilization of deoxyhemoglobin by binding of 2,3-diphosphoglycerate in the beta cleft compared well with experimental binding behavior for human hemoglobin a0 and hemoglobin f . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
55,
65
]
} | {
"id": "C0015936",
"name": "hemoglobin f",
"pos": [
198,
210
]
} |
a direct competition was formulated between these two effectors , with extension to include a simple anion such as chloride or bicarbonate binding in competition with diphosphoglycerate but not with val-1 beta carbamino formation . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
101,
106
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
115,
123
]
} |
the kinetics and mechanism of binding of cu- ( ii ) .bleomycin , fe ( iii ) .bleomycin , and cu ( ii ) .phleomycin to dna were studied by using fluorometry , equilibrium dialysis , electric dichroism , and temperature-jump and stopped-flow spectrophotometry . | NA | {
"id": "C0005740",
"name": "bleomycin",
"pos": [
53,
62
]
} | {
"id": "C0031559",
"name": "phleomycin",
"pos": [
104,
114
]
} |
dna was lengthened by 4.6 a/molecule of bound cu ( ii ) .bleomycin and by 3.2 a/bound fe ( iii ) .bleomycin but not at all by cu ( ii ) .phleomycin , suggesting that both bleomycin complexes intercalate while the phleomycin complex does not . | NA | {
"id": "C0005740",
"name": "bleomycin",
"pos": [
57,
66
]
} | {
"id": "C0031559",
"name": "phleomycin",
"pos": [
213,
223
]
} |
the important feature of this model is a shifted parallel alignment of both polypeptide chains resulting in one free n-terminal stretch for each l7/l12 dimer which attaches the protein to the ribosome via protein l10 . | NA | {
"id": "C0035552",
"name": "protein",
"pos": [
177,
184
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
205,
212
]
} |
radioimmunoassay was performed with 125i-labeled ldl and several homologous antisera , each corresponding to different periods ( 1 -- 18 weeks ) of immunization and thus containing various antibody populations . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
76,
84
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
189,
197
]
} |
studies with antisera corresponding to different periods of immunization ( 2 , 4 , and 8 weeks ) indicated that antibodies reacting with mannose appeared early ( maximum 31 % inhibition at 2 weeks ) , disappearing at 6 -- 8 weeks ; | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
13,
21
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
112,
122
]
} |
that such organization is observed with the predominant cholesteryl ester species of blood and aorta suggests a role for double-layer structure in regulating the transport and metabolism of cholesteryl esters in lipoproteins , arterial lipid deposits , and adrenal cortex . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
212,
224
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
236,
241
]
} |
the inhibition of the two enzyme fractions by 4-methylpyrazole is analogous to that observed for the corresponding isoenzymes of human liver . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
26,
32
]
} | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
115,
125
]
} |
the diffusion constant ( ph 7.5 , 20 degrees c ) of the free enzyme is ( 2.85 +/- 0.005 ) x 10 ( -7 ) cm2 s-1 , of the enzyme . mg2+ complex ( 2.40 +/- 0.05 ) x 10 ( -7 ) cm2 s-1 and of the enzyme . mg2+ . trnaphe complex ( 2.95 +/- 0.06 ) x 10 ( -7 ) cm2 s-1 . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
61,
67
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
190,
196
]
} |
these data indicate that the oligomer is the active form of the enzyme under assay conditions and that certain nondenaturing detergents can inactivate this enzyme by dissociating the enzyme complex . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
64,
70
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
183,
189
]
} |
the two 2-deoxy-d-rhamnose moieties are derived from glucose with retention of the hydrogens at c-1 , c-2 , and c-6 and loss of h-3 and h-5 . | NA | {
"id": "C0020275",
"name": "hydrogens",
"pos": [
83,
92
]
} | {
"id": "C0041119",
"name": "h-3",
"pos": [
128,
131
]
} |
the hydrogen at c-4 of glucose is transferred intramolecularly to c-6 of the hexose , replacing the hydroxyl group at c-6 in an inversion mode , a result which implicates the thymidine 5'-diphosphate-glucose oxidoreductase reaction in this transformation . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
23,
30
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
77,
83
]
} |
the combined sequences specified the amino acid sequences for chicken pro-alpha 1 and pro-alpha 2 type i collagens starting at residue 814 in the collagen triple-helical region and continuing to the procollagen c-termini as determined by the first in-phase termination codon . | NA | {
"id": "C0009325",
"name": "collagen",
"pos": [
105,
113
]
} | {
"id": "C0033235",
"name": "procollagen",
"pos": [
199,
210
]
} |
the kinetics of cytochrome b reduction and oxidation in the ubiquinone-cytochrome b/c2 oxidoreductase of chromatophores from rhodopseudomonas sphaeroides ga have been measured both in the presence and absence of antimycin , after subtraction of contributions due to absorption changes from cytochrome c2 , the oxidized bacteriochlorophyll dimer of the reaction center , and a red shift of the antenna bacteriochlorophyll . | NA | {
"id": "C0004638",
"name": "bacteriochlorophyll",
"pos": [
319,
338
]
} | {
"id": "C0600166",
"name": "a",
"pos": [
402,
403
]
} |
similarly , neither cation was essential for the enhanced 2-deoxy-d- [ 3h ] glucose uptake stimulated by two chemotactic factors ( c5a and n-formylmethionylleucylphenylalanine ) and arachidonic acid : enhanced uptake was only partially depressed by the omission of ca2+ and mg2+ from the suspensions and was still prominent in the presence of edta . | NA | {
"id": "C0008013",
"name": "chemotactic factors",
"pos": [
109,
128
]
} | {
"id": "C0027229",
"name": "formylmethionylleucylphenylalanine",
"pos": [
141,
175
]
} |
separation of the radioactive hexosamines from acid hydrolysates of cells incubated with [ 14c ] glucosamine and tunicamycin showed predominant labelling of galactosamine , whereas in control cells not treated with the drug both glucosamine and galactosamine were labelled equally . | NA | {
"id": "C0019478",
"name": "hexosamines",
"pos": [
30,
41
]
} | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
229,
240
]
} |
separation of the radioactive hexosamines from acid hydrolysates of cells incubated with [ 14c ] glucosamine and tunicamycin showed predominant labelling of galactosamine , whereas in control cells not treated with the drug both glucosamine and galactosamine were labelled equally . | NA | {
"id": "C0019478",
"name": "hexosamines",
"pos": [
30,
41
]
} | {
"id": "C0016943",
"name": "galactosamine",
"pos": [
245,
258
]
} |
the effect of dicarboxylic phosphatidylcholines ( glutaryl phosphatidylcholine ) on the stability and phase transition of phosphatidylcholine liposomes is examined by using liposomes prepared with egg phosphatidylcholine or dipalmitoyl phosphatidylcholine and by varying the surface charge by addition of dicetyl phosphate . | NA | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
27,
46
]
} | {
"id": "C0000039",
"name": "dipalmitoyl",
"pos": [
224,
235
]
} |
when s-benzyl-n-acetyl-l- [ u-14c ] cysteine , a mercapturic acid , was administered to rats intravenously , the plasma level of radioactivity decreased very rapidly with a concomitant increase in the renal level of radioactivity . | NA | {
"id": "C0010654",
"name": "cysteine",
"pos": [
36,
44
]
} | {
"id": "C0001047",
"name": "mercapturic acid",
"pos": [
49,
65
]
} |
the electrogenic action of the basic amino acid , l-arginine , has been compared with the action of the neutral amino acids , l-alanine and glycine , in mouse pancreatic acinar cells . | NA | {
"id": "C0301714",
"name": "basic amino acid",
"pos": [
31,
47
]
} | {
"id": "C0003765",
"name": "l-arginine",
"pos": [
50,
60
]
} |
the results suggest that the interaction of exogeneously added enzyme with the membranes is primarily dependent on lipid components or some specific lipid environment on the acceptor membranes . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
115,
120
]
} | {
"id": "C0025249",
"name": "lipid",
"pos": [
149,
154
]
} |
the synthesis of membrane proteins with electrophoretic mobilities similar to bands 3 and 4 was increased 2 -- 3-fold by the fourth day , while bands 6 and 5 proteins attained maximal synthesis ( 4-fold ) on the fifth and sixth days of treatment . | NA | {
"id": "C0034861",
"name": "synthesis",
"pos": [
4,
13
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
158,
166
]
} |
still , the decline in the intracellular level of carnitine was prevented by the corticoid hormone . | NA | {
"id": "C0001617",
"name": "corticoid",
"pos": [
81,
90
]
} | {
"id": "C0019932",
"name": "hormone",
"pos": [
91,
98
]
} |
nucleoside analyses revealed both pseudouridine and 5-methyl-uridine levels to be reduced more extensively at low levels of analog incorporation than could be accounted for by a stoichiometric replacement , as observed earlier with escherichia coli . | NA | {
"id": "C0033846",
"name": "pseudouridine",
"pos": [
34,
47
]
} | {
"id": "C0041984",
"name": "uridine",
"pos": [
61,
68
]
} |
comparing these properties with those of the renal cytoplasmic and the human red cell b and c isozymes , it appears that the membrane enzyme is quite different from the soluble carbonic anhydrases . | NA | {
"id": "C0022173",
"name": "isozymes",
"pos": [
94,
102
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
134,
140
]
} |
a routine procedure for the growth and harvesting of large ( 600 1 ) batches of chromatium vinosum and the isolation of hydrogenase ( hydrogen : ( acceptor ) oxidoreductase , ec 1.12.-.- ) are described . | NA | {
"id": "C0020284",
"name": "hydrogenase",
"pos": [
120,
131
]
} | {
"id": "C0030016",
"name": "ec 1",
"pos": [
175,
179
]
} |
the enzyme system incorporated delta-n-acetyl-delta-n-hydroxyornithine into ferrichrome and catalyzed atp-pp1 exchange reactions , dependent on the constituent amino acids , glycine and delta-n-acetyl-delta-n-hydroxyornithine , in the presence of mg2+ . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
160,
171
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
174,
181
]
} |
on polyacrylamide gel electrophoresis sulphatase a migrates as a single protein band which coincides with both the arylsulphatase and phosphodiesterase activities , suggesting that these are due to a single protein . | NA | {
"id": "C0038717",
"name": "sulphatase",
"pos": [
38,
48
]
} | {
"id": "C0003940",
"name": "arylsulphatase",
"pos": [
115,
129
]
} |
immunological homology was shown between the active site regions of pig and rabbit aminopeptidases n and between those of the corresponding aminopeptidases a . | NA | {
"id": "C0054943",
"name": "aminopeptidases n",
"pos": [
83,
100
]
} | {
"id": "C0002570",
"name": "aminopeptidases",
"pos": [
140,
155
]
} |
also , the results suggest that in vivo esterified cholesterol fractions of vldl and ldl originate from hdl , that some ldl ester is transferred back to hdl , and that the cholesterol liberated form hydrolyzed esters undergoes recirculation into the free cholesterol pool rather than excretion as biliary cholesterol or bile acids . | NA | {
"id": "C0023826",
"name": "in",
"pos": [
32,
34
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
305,
316
]
} |
also , the results suggest that in vivo esterified cholesterol fractions of vldl and ldl originate from hdl , that some ldl ester is transferred back to hdl , and that the cholesterol liberated form hydrolyzed esters undergoes recirculation into the free cholesterol pool rather than excretion as biliary cholesterol or bile acids . | NA | {
"id": "C0008387",
"name": "cholesterol",
"pos": [
51,
62
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
305,
316
]
} |
independent evidence for the absolute configurations was obtained by capillary gas-liquid chromatography of diastereomeric r- ( - ) -2-butyl esters of the acetylated 2-hydroxy carboxylic acids produced by oxidative ozonolysis of the acetylated dihydroxy fatty acids . | NA | {
"id": "C0014898",
"name": "esters",
"pos": [
141,
147
]
} | {
"id": "C0007066",
"name": "carboxylic acids",
"pos": [
176,
192
]
} |
in this study it was found that the 14co2 formation from the 14c-labeled lanosterol was inhibited by antibodies to yeast cytochrome b5 and by palmitoyl-coa , a substrate of the cytochrome b5-containing fatty acyl-coa desaturase system of yeast microsomes . | NA | {
"id": "C0030239",
"name": "palmitoyl-coa",
"pos": [
142,
155
]
} | {
"id": "C0001374",
"name": "fatty acyl-coa",
"pos": [
202,
216
]
} |
chylomicron remnants ( sf greater than 100 ) were prepared by treating human chylomicrons ( sf greater than 400 ) with human post heparin plasma . | NA | {
"id": "C0443616",
"name": "chylomicron remnants",
"pos": [
0,
20
]
} | {
"id": "C0008731",
"name": "chylomicrons",
"pos": [
77,
89
]
} |
chylomicron remnants recovered after 70-80 % of chylomicron triacylglycerol was hydrolyzed , suppressed ldl-receptor activity and increased cell cholesterol esterification to the same extent as did ldl when added to cultured human arterial smooth muscle cells at an equal cholesterol concentration . | NA | {
"id": "C0443616",
"name": "chylomicron",
"pos": [
0,
11
]
} | {
"id": "C0008731",
"name": "chylomicron",
"pos": [
48,
59
]
} |
cell cholesterol mass increased 36 % after incubation with 25 micrograms ldl cholesterol/ml and 35 % with 25 micrograms chylomicron-remnant cholesterol/ml . | NA | {
"id": "C0023824",
"name": "ldl cholesterol",
"pos": [
73,
88
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
140,
151
]
} |
with 100 micrometers acetylcholine , the proportions of individual fatty acids in diacylglycerol showed a significant enrichment of stearic and arachidonic acid at 40 min and of linoleic and arachidonic acids at 80 min . | NA | {
"id": "C0003695",
"name": "arachidonic acid",
"pos": [
144,
160
]
} | {
"id": "C0003701",
"name": "arachidonic acids",
"pos": [
191,
208
]
} |
hepatocyte d less than 1.006 and d 1.006-1.063 g/ml lipoproteins were similar to plasma very low density lipoprotein ( vldl ) and low density lipoprotein ( ldl ) , respectively , in chemical composition , morphology and apolipoprotein distribution . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
52,
64
]
} | {
"id": "C0023825",
"name": "very low density lipoprotein",
"pos": [
88,
116
]
} |
the differences in affinity did not correlate with total fatty acid content ( r = -0.39 ) , total unsaturated fatty acid content ( r = -0.26 ) , or with the content of fatty acids containing two or more double bonds ( r = -0.01 ) . | NA | {
"id": "C0015690",
"name": "unsaturated fatty acid",
"pos": [
98,
120
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
168,
179
]
} |
monolayer chondrocytes produced higher levels of prostaglandin e2 relative to 6-oxo-prostaglandin f1 alpha than did spinner cells , but the latter synthesized more total prostaglandins . | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
10,
22
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
124,
129
]
} |
the skin surface lipids of the gerbil were found to consist sterol esters ( 10 % ) , wax diesters ( 36.3 % ) , triacylglycerol ( 26.1 % ) , free fatty alcohols ( 8.8 % ) , free fatty acids ( 5.4 % ) , cholesterol ( 8.4 % ) and polar lipids ( 5 % ) . | NA | {
"id": "C0043076",
"name": "wax",
"pos": [
85,
88
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
233,
239
]
} |
in addition , whereas fetal slices contained significantly more radioactivity in choline phosphate and cdpcholine , adult slices incorporated significantly more [ 14c ] choline into phosphatidylcholine . | NA | {
"id": "C0031716",
"name": "choline phosphate",
"pos": [
81,
98
]
} | {
"id": "C0008405",
"name": "choline",
"pos": [
194,
201
]
} |
in addition , whereas fetal slices contained significantly more radioactivity in choline phosphate and cdpcholine , adult slices incorporated significantly more [ 14c ] choline into phosphatidylcholine . | NA | {
"id": "C0010725",
"name": "cdpcholine",
"pos": [
103,
113
]
} | {
"id": "C0008405",
"name": "choline",
"pos": [
194,
201
]
} |
experiments with [ 3h ] choline and 32pi revealed that the 3h/32p ratio of choline phosphate in fetal or adult slices was identical to the isotopic ratio in phosphatidylcholine , indicating that under the experimental conditions , negligible radioactivity was incorporated by base-exchange . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
24,
31
]
} | {
"id": "C0031716",
"name": "choline phosphate",
"pos": [
75,
92
]
} |
the rates of peptide nh exchange with solvent for [ asn1 , val5 ] angiotensin ii , angiotensin iii and saralasin . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
66,
80
]
} | {
"id": "C0036193",
"name": "saralasin",
"pos": [
103,
112
]
} |
the amide hydrogen exchange rates in h2o of two angiotensin agonists ( angiotensinamide and angiotensin iii ) and one angiotensin antagonist ( saralasin ) have been measured at room temperature by the transfer of solvent saturation method . | NA | {
"id": "C0003012",
"name": "angiotensin iii",
"pos": [
92,
107
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
118,
129
]
} |
the results indicate that hb fia1 , hb fia2 , and hb fic have been formed by the modification of gamma chains of hb f by reacting with fructose-1,6-p2 , glucose-6-p , and glucose , respectively . | NA | {
"id": "C0019046",
"name": "hb",
"pos": [
26,
28
]
} | {
"id": "C0015936",
"name": "hb f",
"pos": [
113,
117
]
} |
incubations of hb f with [ 14c ] hexoses and subsequent chromatographic separation of hemoglobins and their globin chains confirm the previous findings that the binding of carbohydrate to hb involves both specific and nonspecific reactions . | NA | {
"id": "C0015936",
"name": "hb f",
"pos": [
15,
19
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
188,
190
]
} |
two of these proteins were similar in composition to b2 globulin and may represent degradation products of some larger protein . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
13,
21
]
} | {
"id": "C0017649",
"name": "globulin",
"pos": [
56,
64
]
} |
this population of low molecular weight plasma proteins has previously been shown to contain the cystic fibrosis mucociliary inhibitor and is here shown to contain two proteins similar to b2 globulin , c3a and many proteins remaining to be characterized . | NA | {
"id": "C0017649",
"name": "globulin",
"pos": [
191,
199
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
215,
223
]
} |
experiments have been carried out with fibrinogen and with purified degradation products of fibrinogen and fibrin which demonstrate that the structure of d fragments obtained after prolonged plasmin digestion is influenced by several factors in the media . | NA | {
"id": "C0163275",
"name": "degradation",
"pos": [
68,
79
]
} | {
"id": "C0015982",
"name": "fibrin",
"pos": [
107,
113
]
} |
the protein copper can be removed by diethyldithiocarbamate and the procedure of reconstitution of holoprotein from apoprotein and cu2+ was developed . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
4,
11
]
} | {
"id": "C0003601",
"name": "apoprotein",
"pos": [
116,
126
]
} |
similar results were obtained with related peptide hormones such as human growth hormone , chicken growth hormone , and human placental lactogen . | NA | {
"id": "C0169964",
"name": "human growth",
"pos": [
68,
80
]
} | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
99,
113
]
} |
a study of the ability of this catecholamine to stimulate adenylate cyclase activity of broken-cell preparations revealed that ( +/- ) -hydroxybenzylisoproterenol was equipotent to ( - ) -isoproterenol in liver cell homogenates , while 3- to 4-fold more potent than ( - ) -isoproterenol in fat cell ghost membranes . | NA | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
31,
44
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
273,
286
]
} |
in the plasma of 19-day fetuses , there is only one lipoprotein electrophoretic band which corresponds to the beta-lipoproteins of adults ( low density lipoproteins , ldl ) according to its mobility and floating characteristics , while in the fetus of 21 days there are also pre-beta-lipoproteins ( vldl ) . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
52,
63
]
} | {
"id": "C0023825",
"name": "vldl",
"pos": [
299,
303
]
} |
the responses of the common internal iliac artery and middle uterine artery of the pregnant horn to continuous infusions of graded doses of norepinephrine , epinephrine , dopamine , isoxsuprine , angiotensin and nitroprusside were investigated in chronically instrumental pregnant ewes . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
140,
154
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
157,
168
]
} |
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