text
stringlengths 57
1.72k
| relation
stringclasses 125
values | h
dict | t
dict |
|---|---|---|---|
the angiotensin analog ( sar1 leu8 ) -aii has low efficacy and is a potent competitive antagonist of the parent peptide in pressor and myotropic systems , but is a full agonist with even greater potency than aii in stimulating jejunal transport . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
4,
15
]
} | {
"id": "C0003009",
"name": "aii",
"pos": [
208,
211
]
} |
results of these studies demonstrate that the end-products of the pathway , purine nucleotides , control the activity of the enzyme that catalyzes the first reaction leading to purine nucleotide synthesis either through a direct effect of purine nucleotides on the enzyme , through an indirect effect of the change in nucleotides on pp-ribose-p synthesis , or a combination of these effects . | NA | {
"id": "C0034137",
"name": "purine nucleotides",
"pos": [
76,
94
]
} | {
"id": "C0028630",
"name": "nucleotides",
"pos": [
318,
329
]
} |
the secretory protein content ( determined by measuring the level of alpha-amylase activity ) and the synthesis of proteins ( assayed by the rate of incorporation of 3h-leucine into acid-insoluble proteins ) decline with increasing age . | NA | {
"id": "C0034861",
"name": "synthesis",
"pos": [
102,
111
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
197,
205
]
} |
glucosamine and n-acetyl glucosamine were the most effective , whereas neutral sugars such as sucrose were less effective . | NA | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
0,
11
]
} | {
"id": "C0001056",
"name": "n-acetyl glucosamine",
"pos": [
16,
36
]
} |
glucosamine and n-acetyl glucosamine were the most effective , whereas neutral sugars such as sucrose were less effective . | NA | {
"id": "C0242209",
"name": "sugars",
"pos": [
79,
85
]
} | {
"id": "C0038636",
"name": "sucrose",
"pos": [
94,
101
]
} |
in order to test if there is an alteration in major surface proteins in human fibroblasts as they become senescent in vitro , activity of specific antisera against presenescent and senescent cells was measured . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
78,
89
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
191,
196
]
} |
swiss 3t3-4 mouse fibroblasts were chosen as an example of highly adherent untransformed cells with prominent microfilament bundles , and l929 mouse fibroblasts were chosen as an example of poorly adherent , rounded , transformed cells with prominent microvilli . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
18,
29
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
230,
235
]
} |
a fuller understanding of the factors affecting vitamin d utilisation is needed to completely explain rickets and osteomalacia . | NA | {
"id": "C0035579",
"name": "rickets",
"pos": [
102,
109
]
} | {
"id": "C0029442",
"name": "osteomalacia",
"pos": [
114,
126
]
} |
when normal peripheral blood mononuclear cells were fractionated , fmc7 reacted with only the b-enriched fraction , staining some but not all cells expressing smig . | NA | {
"id": "C1321301",
"name": "peripheral",
"pos": [
12,
22
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
142,
147
]
} |
genetics of natural antitumor antibody production : antibodies to mhc-linked determinants detected in the serum of unstimulated mice . | NA | {
"id": "C0003251",
"name": "antitumor antibody",
"pos": [
20,
38
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
52,
62
]
} |
from studies in which it was demonstrated that allogeneic nab were absorbed with splenocytes bearing the haplotype of the target cell but not by other splenocytes , it was concluded that allo-nab were recognizing h-2 antigenic determinants , or an antigen ( s ) whose expression is closely linked to the mhc . | NA | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
217,
239
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
248,
255
]
} |
cell volume analysis indicated that 63d3-negative cells were identical to the non-adherent cells ( nac ) in pbm , whereas 63d3-positive cells had a bimodal size distribution comparable to glass-adherent cells ( ac ) . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
50,
55
]
} | {
"id": "C1321301",
"name": "pbm",
"pos": [
108,
111
]
} |
upon activation , this protein was incorporated into a macromolecular complex that closely resembles a membrane attack complex ( mac ) of human and guinea pig complement . | NA | {
"id": "C0009545",
"name": "membrane attack complex",
"pos": [
103,
126
]
} | {
"id": "C0009498",
"name": "complement",
"pos": [
159,
169
]
} |
secretion of macrophage-derived growth factor may be relevant to the function of mononuclear phagocytes in several pathologic processes , including the neovascularization and fibroplasia of wound healing , smooth muscle hyperplasia in atherosclerosis , and proliferative glomerulonephritis . | NA | {
"id": "C0030660",
"name": "pathologic processes",
"pos": [
115,
135
]
} | {
"id": "C0016059",
"name": "fibroplasia",
"pos": [
175,
186
]
} |
the antibody facilitates neutralization by forming an immune complex that activates c1 and thus efficiently initiates the classical pathway at the viral surface . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
4,
12
]
} | {
"id": "C0003313",
"name": "immune complex",
"pos": [
54,
68
]
} |
furthermore , since alpha 1 antichymotrypsin and alpha 1 antitrypsin are acute phase proteins , the increase in plasma concentration or turnover rates of the proteins could influence natural killer cell activity in vivo . | NA | {
"id": "C0002190",
"name": "alpha 1 antichymotrypsin",
"pos": [
20,
44
]
} | {
"id": "C0001347",
"name": "acute phase proteins",
"pos": [
73,
93
]
} |
furthermore , since alpha 1 antichymotrypsin and alpha 1 antitrypsin are acute phase proteins , the increase in plasma concentration or turnover rates of the proteins could influence natural killer cell activity in vivo . | NA | {
"id": "C0002191",
"name": "alpha 1",
"pos": [
20,
27
]
} | {
"id": "C0001347",
"name": "acute phase proteins",
"pos": [
73,
93
]
} |
the ability of lymph node cells from mice bearing the bcl1 tumor to respond in vitro to mitogens , allogeneic cells , and both ti and td antigens was investigated . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
99,
115
]
} |
after determining the antiserum was specific for ifn gamma and did not neutralize other known types of interferon , it was used with antibody to human ifn alpha to demonstrate the type ( s ) of interferon stimulated by some new inducers and antigens . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
22,
31
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
133,
141
]
} |
[ 3h ] thymidine incorporation and 51cr-release from appropriate allogeneic target cells were determined either directly in the same hanging drop or after cell transfer and serial 2-fold dilutions in new terasaki plates . | NA | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
65,
75
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
155,
159
]
} |
examples are given where inclusion of an anti-responder alloantiserum plus complement on day 0 of the mlc eliminated the day 4 cytotoxic response , and where treatment of cytotoxic effector cells with alloantiserum plus complement for 1 h prior to the 51cr-release assay eliminated the effector cell activity . | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
75,
85
]
} | {
"id": "C0009499",
"name": "complement",
"pos": [
220,
230
]
} |
antibody bound in an antigen-antibody complex was barely detectable by the standard farr technique using 10 microgram/ml of radiolabeled antigen . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
0,
8
]
} | {
"id": "C0003313",
"name": "antigen-antibody complex",
"pos": [
21,
45
]
} |
antibody bound in immune complexes can be detected with a modified farr technique using a high concentration of antigen and/or by pretreatment of the complexes with low ph buffers before the addition of radiolabeled antigen . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
0,
8
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
18,
34
]
} |
the assay has been optimized with respect to amount of antiserum needed for coating staphylococci , concentration of antibody-coated staphylococci , ph and ionic strength of the assay system , and stirring speed of the aggregometer . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
55,
64
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
117,
125
]
} |
haptens , such as trinitrochlorobenzene ( tncb ) , bind to autologous skin proteins in the induction of allergic content sensitivity . | NA | {
"id": "C0018593",
"name": "haptens",
"pos": [
0,
7
]
} | {
"id": "C0031891",
"name": "trinitrochlorobenzene",
"pos": [
18,
39
]
} |
an exogenous agent could account for the circulating immune complexes ' cross-reactions for the group as a whole , and two antigenic determinants of that agent or antigens from different damaged tissues explain the subsets . | NA | {
"id": "C0003316",
"name": "antigenic",
"pos": [
123,
132
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
163,
171
]
} |
in plasma only 5.6 % of the infused steroid was recovered as unconverted progesterone and the major amount was metabolized to polar compounds with smaller amounts of 5 alpha-pregnane-3,20-dione , 5 alpha-pregnan-3 beta-ol-20-one and 20 alpha hydroxypregn-4-en-3-one . | NA | {
"id": "C0038317",
"name": "steroid",
"pos": [
36,
43
]
} | {
"id": "C0033006",
"name": "pregnane",
"pos": [
174,
182
]
} |
[ biotransformation of zipeprol ( mirsol ) in humans . gas chromatographic/mass spectrometric studies , using ammonia as a selective reactant gas ( author 's transl ) ] . | NA | {
"id": "C0002607",
"name": "ammonia",
"pos": [
110,
117
]
} | {
"id": "C0017110",
"name": "gas",
"pos": [
142,
145
]
} |
the analysis of aspirin and nonaspirin salicylates in buffered and plain tablet formulations employing nearly nonaqueous extraction is described . | NA | {
"id": "C0004057",
"name": "aspirin",
"pos": [
16,
23
]
} | {
"id": "C0036077",
"name": "salicylates",
"pos": [
39,
50
]
} |
a simultaneous assay for aspirin and nonaspirin salicylates in buffered tablets involves the use of an acidified chromatographic siliceous earth column for the separation of the aspirin and nonaspirin salicylates from various buffers or antacids . | NA | {
"id": "C0004057",
"name": "aspirin",
"pos": [
25,
32
]
} | {
"id": "C0036077",
"name": "salicylates",
"pos": [
201,
212
]
} |
several conflicting observations in the literature raised considerable doubt about the metabolic fate of doxycycline , which , like other tetracyclines , has been claimed to be metabolically inert . | NA | {
"id": "C0013090",
"name": "doxycycline",
"pos": [
105,
116
]
} | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
138,
151
]
} |
thus , the different excretion behavior of doxycycline , compared to other analogs , can not be explained in terms of increased metabolism . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
21,
30
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
128,
138
]
} |
the rat cerebral cortex was dissected in five regions and analyzed for the catecholamines noradrenaline , adrenaline and dopamine , and for the indoleamine serotonin using sensitive radioenzymatic assay methods with thin-layer chromatography . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
90,
103
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
106,
116
]
} |
each nerve segment of 5 mm in length retains 1.5 % of the transported proteins , and the profile of retained proteins along the sciatic nerves follows a single exponential function . | NA | {
"id": "C0007292",
"name": "transported proteins",
"pos": [
58,
78
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
109,
117
]
} |
from the proportion of retained proteins , the concentration of transported proteins at the terminals of branching axons as a function of the branching ratio was estimated . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
32,
40
]
} | {
"id": "C0007292",
"name": "transported proteins",
"pos": [
64,
84
]
} |
in the case of motor axons innervating the soleus muscle of the cat , the concentration of recently transported proteins at the nerve terminals would be approximately 0.83 % of the proteins leaving the spinal cord . | NA | {
"id": "C0007292",
"name": "transported proteins",
"pos": [
100,
120
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
181,
189
]
} |
acetylcholinesterase ( ec 3.1.1.7. ; ache ) and butyrylcholinesterase ( ec 3.1.1.8. ; buche ) from chicken muscle exist as sets of structurally homologous forms with very similar properties . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
0,
20
]
} | {
"id": "C0008429",
"name": "butyrylcholinesterase",
"pos": [
48,
69
]
} |
the release of labelled fatty acids from phosphatidylcholine by the neuronal plasma membrane phospholipase a1 decreased with increasing degree of unsaturation of the fatty acids at the 1 position . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
24,
35
]
} | {
"id": "C0015690",
"name": "unsaturation",
"pos": [
146,
158
]
} |
inhibition of ca release was also obtained with naloxone ( id50 = 14 ) microm ) and naltrexone ( id50 greater than 10 ( -4 ) m ) , two classical antagonists of opiate receptors , and this effect was additive to that of beta-endorphin . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
48,
56
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
84,
94
]
} |
seizures were observed in 22 patients , but epileptic eeg patterns appeared only when the bismuth blood level was below 1500 microgram/1 . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
0,
8
]
} | {
"id": "C0014544",
"name": "epileptic",
"pos": [
44,
53
]
} |
antibodies to viral and non-viral antigens in subacute sclerosing panencephalitis and multiple sclerosis demonstrated by thin-layer polyacrylamide gel isoelectric focusing , antigen immunofixation and autoradiography . | NA | {
"id": "C0003342",
"name": "viral antigens",
"pos": [
28,
42
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
174,
181
]
} |
five patients , four with sinusitis and subdural empyema and one with sinusitis and brain abscess , did not respond to antimicrobial therapy and aspiration of the abscess , and required surgical drainage of their inflamed sinuses . | NA | {
"id": "C0006105",
"name": "brain abscess",
"pos": [
84,
97
]
} | {
"id": "C0000833",
"name": "abscess",
"pos": [
163,
170
]
} |
myocarditis and cardiomyopathy occur in 50 % of patients who go on to develop chronic chagas ' disease . | NA | {
"id": "C0027059",
"name": "myocarditis",
"pos": [
0,
11
]
} | {
"id": "C0878544",
"name": "cardiomyopathy",
"pos": [
16,
30
]
} |
percentage net phosphorus availability ( npha ) and set phosphorus utilization ( nphu ) of the phosphorus contained in a heat-sterilized poultry litter ( pl ) as compared to feed grade dicalcium phosphate ( dcp ) for lambs was assessed by the `` '' slope '' '' method . | NA | {
"id": "C0031705",
"name": "phosphorus",
"pos": [
15,
25
]
} | {
"id": "C0795598",
"name": "dicalcium phosphate",
"pos": [
185,
204
]
} |
the percentage of npha was found to be 63.7 and 39 , and that of nphu was 63 and 38 for the phosphorus supplied by dcp and pl , respectively . | NA | {
"id": "C0031705",
"name": "phosphorus",
"pos": [
92,
102
]
} | {
"id": "C0795598",
"name": "dcp",
"pos": [
115,
118
]
} |
thus , the npha or nphu for the phosphorus contained in pl is 60.9 and 60.3 % of that of dcp , respectively . | NA | {
"id": "C0031705",
"name": "phosphorus",
"pos": [
32,
42
]
} | {
"id": "C0795598",
"name": "dcp",
"pos": [
89,
92
]
} |
sprague-dawley rats were fed high carbohydrate ( 5 % corn oil ) , all unsaturated fat ( 20 % corn oil ) or all saturated fat ( 20 % coconut oil ) diets containing either basal ( 0.15 % nacl ) or high ( 8.0 % nacl ) levels of salt . | NA | {
"id": "C0012172",
"name": "unsaturated fat",
"pos": [
70,
85
]
} | {
"id": "C0010029",
"name": "corn oil",
"pos": [
93,
101
]
} |
rapid and essentially synchronous vitamin a deficiency was induced by the withdrawal of retinoic acid from stringently deficient animals reared by feeding early weight plateau vitamin a-deprived male rats diets first supplemented with and then lacking in 2 micrograms retinoic acid/g diet in repeating 18:10 day cycles . | NA | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
34,
43
]
} | {
"id": "C0040845",
"name": "retinoic acid",
"pos": [
268,
281
]
} |
initial therapy was ampicillin or amoxicillin ( 31 ) , trimethoprim-sulfamethoxazole ( 5 ) , erythromycin and sulfisoxazole ( 5 ) , erythromycin ( 1 ) , and ampicillin and gentamicin ( 1 ) . | NA | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
34,
45
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
157,
167
]
} |
resistant isolates from children initially treated with ampicillin or amoxicillin were sensitive to trimethoprim-sulfamethoxazole or to erythromycin and sulfisoxazole , and vice versa . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
56,
66
]
} | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
70,
81
]
} |
when ethanol ( 2 g/kg i.p . ) was administered 48 hr after termination of ethanol inhalation , the ethanol vapor-treated animals maintained normal body temperatures despite the presence of blood ethanol concentrations ( 1.81 +/- 0.04 mg/ml ) which caused hypothermia in control animals . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
5,
12
]
} | {
"id": "C0684262",
"name": "blood ethanol concentrations",
"pos": [
189,
217
]
} |
acute and chronic effects of naltrexone and naloxone on schedule-controlled behavior of squirrel monkeys and pigeons . | NA | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
29,
39
]
} | {
"id": "C0027358",
"name": "naloxone",
"pos": [
44,
52
]
} |
dose-effect curves were obtained for the influence of naltrexone , of naloxone and of morphine on lever-pressing responses of squirrel monkeys and key-pecking responses of pigeons maintained by food presentation during fixed-interval ( fi ) and fixed-ratio ( fr ) components of a multiple schedule . | NA | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
54,
64
]
} | {
"id": "C0027358",
"name": "naloxone",
"pos": [
70,
78
]
} |
naltrexone doses as low as 0.03 mg/kg ( monkeys ) or 0.1 mg/kg ( pigeons ) and naloxone doses as low as 0.1 mg/kg ( monkeys ) or 1 mg/kg ( pigeons ) shifted morphine dose-effect curves by one or more log units to the right . | NA | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
0,
10
]
} | {
"id": "C0027358",
"name": "naloxone",
"pos": [
79,
87
]
} |
the effects of a 3 mg/kg injection of morphine were blocked completely by naltrexone ( 0.1-0.3 mg/kg ) injected up to 16 hr before morphine , but not by naloxone ( 0.3-1 mg/kg ) injected more than 2 hr before morphine . | NA | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
74,
84
]
} | {
"id": "C0027358",
"name": "naloxone",
"pos": [
153,
161
]
} |
given alone , only high doses of naltrexone or naloxone ( 10 mg/kg , monkeys ; 56 mg/kg , pigeons ) had pronounced actions ; | NA | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
33,
43
]
} | {
"id": "C0027358",
"name": "naloxone",
"pos": [
47,
55
]
} |
repeated daily injections of these high doses of naltrexone or naloxone resulted in little or no tolerance . | NA | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
49,
59
]
} | {
"id": "C0027358",
"name": "naloxone",
"pos": [
63,
71
]
} |
the ic50 for displacement of [ 3h ] spiroperidol by lisuride in frontal cortex was increased by the gtp analog , 5'-guanylylimidodiphosphate , indicating an agonist-like interaction . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
100,
103
]
} | {
"id": "C0018366",
"name": "guanylylimidodiphosphate",
"pos": [
116,
140
]
} |
clonidine , epinephrine , alpha-methylnorepinephrine and norepinephrine were most potent and methoxamine and phenylephrine least potent in inhibiting the glucose-stimulated insulin release . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
12,
23
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
57,
71
]
} |
clonidine , epinephrine , alpha-methylnorepinephrine and norepinephrine were most potent and methoxamine and phenylephrine least potent in inhibiting the glucose-stimulated insulin release . | NA | {
"id": "C0025805",
"name": "alpha-methylnorepinephrine",
"pos": [
26,
52
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
57,
71
]
} |
in the aorta , the order of agonist potency was norepinephrine greater than phenylephrine greater than epinephrine greater than methoxamine greater than alpha-methylnorepinephrine and that of antagonist potency was prazosin greater than wb-4101 greater than phentolamine greater than dihydroergotamine greater than phenoxybenzamine greater than yohimbine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
48,
62
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
168,
179
]
} |
in the aorta , the order of agonist potency was norepinephrine greater than phenylephrine greater than epinephrine greater than methoxamine greater than alpha-methylnorepinephrine and that of antagonist potency was prazosin greater than wb-4101 greater than phentolamine greater than dihydroergotamine greater than phenoxybenzamine greater than yohimbine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
48,
62
]
} | {
"id": "C0025805",
"name": "alpha-methylnorepinephrine",
"pos": [
153,
179
]
} |
these results clearly demonstrate that the alpha adrenergic receptors in rat pancreatic islets are different from those on rabbit aorta ( alpha-1 ) and are typical postsynaptic alpha-2 adrenergic receptors . | NA | {
"id": "C0034784",
"name": "alpha",
"pos": [
43,
48
]
} | {
"id": "C0001639",
"name": "alpha-2 adrenergic receptors",
"pos": [
177,
205
]
} |
during the transition to the blastocyst , most amino acid pools increased 2-3-fold , but the taurine and glycine pools decreased to about 50 and 10 % , respectively , of the egg value . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
47,
57
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
105,
112
]
} |
uterine cells from hormone-treated ovariectomized animals underwent similar transformations but those from untreated ovariectomized mice gave only isolated islets of epithelial cells and scattered fibroblast-like cells in culture . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
8,
13
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
197,
207
]
} |
specific antisera and iodinated tracers , as well as strict conditions of sample storage pg extraction and purification , were used to estimate prostaglandins ( microgram/ml ) in the semen of fertile men : 19-oh-pge ( 1 + 2 ) ( 350 ) , 19-oh-pgf-alpha ( 22 ) , pge-2 ( 15 ) , pge-1 ( 6.2 ) , pgf-2 alpha ( 2.3 ) , pgf-1 alpha ( 1.3 ) , 6-keto-pgf-1 alpha ( less than 1 ) , pgd-2 , 13,14-dihydro-15-keto-pgf alpha and txb-2 ( less than 0.1 ) . | NA | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
144,
158
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
276,
279
]
} |
specific antisera and iodinated tracers , as well as strict conditions of sample storage pg extraction and purification , were used to estimate prostaglandins ( microgram/ml ) in the semen of fertile men : 19-oh-pge ( 1 + 2 ) ( 350 ) , 19-oh-pgf-alpha ( 22 ) , pge-2 ( 15 ) , pge-1 ( 6.2 ) , pgf-2 alpha ( 2.3 ) , pgf-1 alpha ( 1.3 ) , 6-keto-pgf-1 alpha ( less than 1 ) , pgd-2 , 13,14-dihydro-15-keto-pgf alpha and txb-2 ( less than 0.1 ) . | NA | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
144,
158
]
} | {
"id": "C0033558",
"name": "pgd",
"pos": [
373,
376
]
} |
the incidence of cis has reached a plateau , and the author feels that cis will now decline as earlier stages of cervical intraepithelial neoplasia ( cin ) are being detected and eradicated . | NA | {
"id": "C0007099",
"name": "cis",
"pos": [
17,
20
]
} | {
"id": "C0206708",
"name": "cervical intraepithelial",
"pos": [
113,
137
]
} |
with the aim of obtaining new agents for the photochemotherapy of psoriasis , we have prepared monofunctional reagents for dna by starting from 4,5'-dimethylangelicin ( 2 ) , an angular furocoumarin , and introducing in a 4'- ( hydroxymethyl ) ( 3 ) , 4'- ( methoxymethyl ) ( 4 ) , or 4'- ( aminomethyl ) group ( 5 ) , in way analogous to what other authors have done previously on trioxsalen , a dna bifunctional reagent . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
123,
126
]
} | {
"id": "C0000702",
"name": "a dna",
"pos": [
395,
400
]
} |
with the aim of obtaining new agents for the photochemotherapy of psoriasis , we have prepared monofunctional reagents for dna by starting from 4,5'-dimethylangelicin ( 2 ) , an angular furocoumarin , and introducing in a 4'- ( hydroxymethyl ) ( 3 ) , 4'- ( methoxymethyl ) ( 4 ) , or 4'- ( aminomethyl ) group ( 5 ) , in way analogous to what other authors have done previously on trioxsalen , a dna bifunctional reagent . | NA | {
"id": "C0016859",
"name": "furocoumarin",
"pos": [
186,
198
]
} | {
"id": "C0041086",
"name": "trioxsalen",
"pos": [
382,
392
]
} |
hemoglobin s ( hb s ) , treated with antisickling agents which interfere with gel formation , has been found to migrate on citrate agar electrophoresis in a manner similar to hb a or hb f . | NA | {
"id": "C0019046",
"name": "hb",
"pos": [
15,
17
]
} | {
"id": "C0015936",
"name": "hb f",
"pos": [
183,
187
]
} |
a review of the most recent literature on biliary tract disease in sickle cell ( hbss ) disease has shown gallstones to be present in approximately 67 percent of affected patients . | NA | {
"id": "C0005424",
"name": "biliary tract disease",
"pos": [
42,
63
]
} | {
"id": "C0008350",
"name": "gallstones",
"pos": [
106,
116
]
} |
a fistula between a lacerated middle meningeal artery and the sphenoparietal sinus was discovered in a patient who had increased intracranial pressure following trauma . | NA | {
"id": "C0043246",
"name": "lacerated",
"pos": [
20,
29
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
161,
167
]
} |
trauma recovery is a developing organization which focuses on the psychosocial concerns of those recovering from multiple trauma . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
0,
6
]
} | {
"id": "C0026771",
"name": "multiple trauma",
"pos": [
113,
128
]
} |
although cleft palate abnormalities in infancy invariably cause otitis media , which may result in hearing loss , only rarely have hearing deficits been reported in association with larsen 's disease . | NA | {
"id": "C0011053",
"name": "hearing loss",
"pos": [
99,
111
]
} | {
"id": "C1384666",
"name": "hearing deficits",
"pos": [
131,
147
]
} |
acute lower urinary tract infections were treated in 57 women according to a randomized protocol , using either cefaclor , a cephalosporin whose chemical structure is similar to that of cephalexin , or trimethoprim-sulfamethoxazole combination . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
112,
120
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
186,
196
]
} |
nine adult patients with obstructive sleep apnea syndrome were administered medroxyprogesterone acetate , 60 to 120 mg/day , and the effect of medroxyprogesterone on clinical symptoms and obstructive apneas during sleep was assessed . | NA | {
"id": "C0065864",
"name": "medroxyprogesterone acetate",
"pos": [
76,
103
]
} | {
"id": "C0025147",
"name": "medroxyprogesterone",
"pos": [
143,
162
]
} |
thus the choice of medium is important in studies of lipid-soluble antifolates such as ddmp that have a high affinity for cellular and medium lipoprotein components . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
53,
58
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
142,
153
]
} |
rosette inhibition assay showed that these antigenic determinants were expressed on antigenic structures , which are not associated with beta 2 microglobulin and histocompatibility antigens . | NA | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
43,
65
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
84,
93
]
} |
hermansky-pudlak syndrome is reported from a 5 year old girl presenting with oculocutaneous albinism and bleeding tendency . | NA | {
"id": "C0079504",
"name": "hermansky-pudlak syndrome",
"pos": [
0,
25
]
} | {
"id": "C0078918",
"name": "oculocutaneous albinism",
"pos": [
77,
100
]
} |
in both the media and the adventitia the amount of type i collagen was drastically reduced as shown by quantitation of collagen and procollagen . | NA | {
"id": "C0009325",
"name": "collagen",
"pos": [
58,
66
]
} | {
"id": "C0033235",
"name": "procollagen",
"pos": [
132,
143
]
} |
ventricular tachycardia could be reproducibly induced in 15 patients by programmed stimulation , qrs morphology and rate being comparable to the spontaneously occurring tachycardia . | NA | {
"id": "C0042514",
"name": "ventricular tachycardia",
"pos": [
0,
23
]
} | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
169,
180
]
} |
at rest , atenolol prevented the pacing induced tachycardias ( 20 dysrhythmias in 18 patients ) in 3/5 individuals with wolff-parkinson-white ( wpw ) -syndrome , in 4/6 cases with atrial tachycardias , in 4/6 patients presenting atrial flutter , in 2/2 cases developing av-nodal tachycardias and in 1/1 individual with ventricular tachycardia . | NA | {
"id": "C0003811",
"name": "dysrhythmias",
"pos": [
66,
78
]
} | {
"id": "C0004239",
"name": "atrial flutter",
"pos": [
229,
243
]
} |
at rest , atenolol prevented the pacing induced tachycardias ( 20 dysrhythmias in 18 patients ) in 3/5 individuals with wolff-parkinson-white ( wpw ) -syndrome , in 4/6 cases with atrial tachycardias , in 4/6 patients presenting atrial flutter , in 2/2 cases developing av-nodal tachycardias and in 1/1 individual with ventricular tachycardia . | NA | {
"id": "C0039231",
"name": "tachycardias",
"pos": [
48,
60
]
} | {
"id": "C0042514",
"name": "ventricular tachycardia",
"pos": [
319,
342
]
} |
it could be shown by an immunoprecipitation test using precipitating antibodies against ck-mm and ck-bb that the creatine kinase of the abnormal band consists entirely of the mm-type , which after treatment with polyethylene glycol not only became susceptible to inhibiting anti-m antibodies , but also showed the electrophoretic motility of ck-mm . | NA | {
"id": "C0010289",
"name": "ck-bb",
"pos": [
98,
103
]
} | {
"id": "C0010287",
"name": "creatine kinase",
"pos": [
113,
128
]
} |
it could be shown by an immunoprecipitation test using precipitating antibodies against ck-mm and ck-bb that the creatine kinase of the abnormal band consists entirely of the mm-type , which after treatment with polyethylene glycol not only became susceptible to inhibiting anti-m antibodies , but also showed the electrophoretic motility of ck-mm . | NA | {
"id": "C0010287",
"name": "creatine kinase",
"pos": [
113,
128
]
} | {
"id": "C0010291",
"name": "ck-mm",
"pos": [
342,
347
]
} |
this encouraging experience indicates that the pattern of persistent fetal circulation in the newborn infant who has undergone repair of a diaphragmatic hernia can be successfully managed with ecmo even when efforts to lower pulmonary hypertension and improve oxygenation with vasodilators ( tolazoline , phenothiazine , acetylcholine , or prostaglandin e1 ) and have been ineffective . | NA | {
"id": "C0031190",
"name": "persistent fetal",
"pos": [
58,
74
]
} | {
"id": "C0020542",
"name": "pulmonary hypertension",
"pos": [
225,
247
]
} |
where there were differences , most tended to favor slightly the family pattern of care : older children maintained their use of the center , immunization was somewhat more timely and children over time appeared to make fewer visits to sources of ambulatory care other than the health center . | NA | {
"id": "C1455726",
"name": "older children",
"pos": [
90,
104
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
184,
192
]
} |
in spite of the absence of spleen enlargement , the patient was diagnosed as suffering from felty 's syndrome without splenomegaly . | NA | {
"id": "C0020564",
"name": "enlargement",
"pos": [
34,
45
]
} | {
"id": "C0038002",
"name": "splenomegaly",
"pos": [
118,
130
]
} |
since fibroblasts from controls were also found to synthesize transcobalamin ii ( tc ii ) , a plasma protein shown previously to facilitate the cellular uptake of cbl , it seemed possible that the observed uptake of free cn-cbl was tc ii-mediated . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
6,
17
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
144,
152
]
} |
in a short-term study , however , an elevation of the fh by 11 % after 2 days and by 26 % after 6 days of diabetes was noticed suggesting that a rapid increase of the fh may occur in relation to rapid changes of the glucose level . | NA | {
"id": "C0019046",
"name": "fh",
"pos": [
54,
56
]
} | {
"id": "C0019016",
"name": "a",
"pos": [
203,
204
]
} |
the major increase of cholesterol occurred in very low density lipoproteins ( vldl , 43.5-fold ) followed by intermediate density lipoproteins ( idl , 26-fold ) and low density lipoproteins ( ldl , 6-fold ) with no change in high density lipoproteins ( hdl ) . | NA | {
"id": "C0023825",
"name": "very low density lipoproteins",
"pos": [
46,
75
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
238,
250
]
} |
the major increase of cholesterol occurred in very low density lipoproteins ( vldl , 43.5-fold ) followed by intermediate density lipoproteins ( idl , 26-fold ) and low density lipoproteins ( ldl , 6-fold ) with no change in high density lipoproteins ( hdl ) . | NA | {
"id": "C0065063",
"name": "intermediate density lipoproteins",
"pos": [
109,
142
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
238,
250
]
} |
these particles were rich in apolipoprotein e , and the radioactivity bound to this apolipoprotein was selectively removed by the perfused normal rabbit liver relative to its uptake of apolipoproteins b and c . | NA | {
"id": "C0003595",
"name": "apolipoprotein e",
"pos": [
29,
45
]
} | {
"id": "C0003591",
"name": "apolipoprotein",
"pos": [
185,
199
]
} |
involvement of radical species in the oxidation of aminopyrine and 4-aminoantipyrine by cumene hydroperoxide in rat liver microsomes . | NA | {
"id": "C0002586",
"name": "aminopyrine",
"pos": [
51,
62
]
} | {
"id": "C0002696",
"name": "4-aminoantipyrine",
"pos": [
67,
84
]
} |
under pathological conditions with limited clarification function of the liver res ( alcoholic hepatitis , severe virus hepatitis , cholestasis , cirrhosis of the liver ) they do reach the systemic circulation . | NA | {
"id": "C0023895",
"name": "conditions",
"pos": [
19,
29
]
} | {
"id": "C0019158",
"name": "hepatitis",
"pos": [
120,
129
]
} |
under pathological conditions with limited clarification function of the liver res ( alcoholic hepatitis , severe virus hepatitis , cholestasis , cirrhosis of the liver ) they do reach the systemic circulation . | NA | {
"id": "C0023895",
"name": "conditions",
"pos": [
19,
29
]
} | {
"id": "C0023890",
"name": "cirrhosis of",
"pos": [
146,
158
]
} |
in other experiments in which mmc was not used , fa fibroblasts were shown to be significantly more sensitive than control cells to 6-mercaptopurine ( 6-mp ) , 6-thioguanine ( 6-tg ) , and 6-azauridine ( 6-au ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
52,
63
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
123,
128
]
} |
the apparent synthesis rate of nonmyofibrillar proteins was similar in normal aand dystrophic cells throughout development , but the apparent synthesis rates of myosin heavy chain and the myofibrillar protein fraction were 50 % -- 90 % higher in dystrophic muscle cultures once maturity had been reached ( days 6 -- 14 ) . | NA | {
"id": "C0034861",
"name": "synthesis",
"pos": [
13,
22
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
201,
208
]
} |
a total of 190 patients representing facioscapulohumeral md ( n = 20 ) , limb-girdle md ( n = 50 ) , becker md ( n = 20 ) , duchenne md ( n = 90 ) , and the `` '' intermediate '' '' type of md ( n = 10 ) were studied using simple spirometric respiratory function tests . | NA | {
"id": "C0238288",
"name": "facioscapulohumeral md",
"pos": [
37,
59
]
} | {
"id": "C0026850",
"name": "f",
"pos": [
9,
10
]
} |
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