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a total of 190 patients representing facioscapulohumeral md ( n = 20 ) , limb-girdle md ( n = 50 ) , becker md ( n = 20 ) , duchenne md ( n = 90 ) , and the `` '' intermediate '' '' type of md ( n = 10 ) were studied using simple spirometric respiratory function tests . | NA | {
"id": "C0686353",
"name": "limb-girdle md",
"pos": [
73,
87
]
} | {
"id": "C0026850",
"name": "f",
"pos": [
9,
10
]
} |
only buoyancy was highly predictive of gallstone composition : all 14 patients with floating stones had cholesterol stones ( p less than 0.01 ) , but only one third of the patients with cholesterol stones had stone buoyancy . | NA | {
"id": "C0008350",
"name": "gallstone",
"pos": [
39,
48
]
} | {
"id": "C0006736",
"name": "stone",
"pos": [
209,
214
]
} |
this antibody , which belonged to the igg class of immunoglobulins , acted early in the polymerization process to inhibit the association of fibrin monomers , as indicated by a prolonged lag time and a decreased slope in the polymerization curves . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
5,
13
]
} | {
"id": "C0021017",
"name": "class",
"pos": [
42,
47
]
} |
plasma from persistently infected individuals , one source of viral antigen , contains characteristic 22-nm spherical particles which share a common antigen ( the hepatitis b surface antigen or hbsag ) with the outer envelope of the 42-nm double-shelled dna virus . | NA | {
"id": "C0003342",
"name": "viral antigen",
"pos": [
62,
75
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
183,
190
]
} |
however , specific binding of 125i-labelled lipid-a of lps to b cells was found to be equivalent in lps-responder and lps-nonresponder c3h/hej , c57bl/10 sccr and c57bl/10 scn mice . | NA | {
"id": "C0023767",
"name": "lipid-a",
"pos": [
44,
51
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
118,
121
]
} |
the beta-p-chlorophenyl derivative of gaba , baclofen , is stereospecifically active at the gaba b site whereas it is devoid of activity at the classical gaba a3 site . | NA | {
"id": "C0004609",
"name": "baclofen",
"pos": [
45,
53
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
154,
158
]
} |
we now report that high-affinity saturable binding of 3h-baclofen and 3h-gaba to the gaba b site can be detected in fragments of crude synaptic membranes prepared from rat brain . | NA | {
"id": "C0004609",
"name": "baclofen",
"pos": [
57,
65
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
85,
89
]
} |
the results support the concept of a novel gaba receptor within the mammalian brain and show that gaba and baclofen can compete for the same recognition site . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
43,
47
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
107,
115
]
} |
during the second phase ( the last 4 days ) , the middle part of the gland synthesis approximately 45 mg of the silk protein sericin ( 31 % serine ) and the posterior part of the gland synthesizes approximately 130 mg of the silk protein fibroin ( 46 % glycine , 29 % alanine and 12 % serine ) . | NA | {
"id": "C0074364",
"name": "sericin",
"pos": [
125,
132
]
} | {
"id": "C0074529",
"name": "silk",
"pos": [
225,
229
]
} |
during the second phase ( the last 4 days ) , the middle part of the gland synthesis approximately 45 mg of the silk protein sericin ( 31 % serine ) and the posterior part of the gland synthesizes approximately 130 mg of the silk protein fibroin ( 46 % glycine , 29 % alanine and 12 % serine ) . | NA | {
"id": "C0074529",
"name": "silk",
"pos": [
112,
116
]
} | {
"id": "C0016042",
"name": "fibroin",
"pos": [
238,
245
]
} |
silk fibroin and sericin are detectable by the second day and represent 80 and 50 % respectively of the total proteins produced at day 8 ( refs 1 -- 4 ) . | NA | {
"id": "C0074529",
"name": "silk",
"pos": [
0,
4
]
} | {
"id": "C0016042",
"name": "fibroin",
"pos": [
5,
12
]
} |
silk fibroin and sericin are detectable by the second day and represent 80 and 50 % respectively of the total proteins produced at day 8 ( refs 1 -- 4 ) . | NA | {
"id": "C0074529",
"name": "silk",
"pos": [
0,
4
]
} | {
"id": "C0074364",
"name": "sericin",
"pos": [
17,
24
]
} |
unlike histamine , slow-reacting substances ( srss ) have been assessed very little for their roles in obstructive airways disease . | NA | {
"id": "C0019588",
"name": "histamine",
"pos": [
7,
16
]
} | {
"id": "C0037343",
"name": "slow-reacting substances",
"pos": [
19,
43
]
} |
replacement therapy with l-thyroxine : serum thyroid hormone and thyrotropin levels in hypothyroid patients changing from desiccated thyroid to pure thyroxine substitution therapy . | NA | {
"id": "C0040135",
"name": "thyroid hormone",
"pos": [
45,
60
]
} | {
"id": "C0040134",
"name": "desiccated thyroid",
"pos": [
122,
140
]
} |
sulpiride and other benzamides ' displacement of [ 3h ] -spiroperidol binding to rat and dog anterior pituitary dopaminergic receptors was found to be selectively sodium dependent , while typical neuroleptic activity was not influenced by nacl . | NA | {
"id": "C0038803",
"name": "sulpiride",
"pos": [
0,
9
]
} | {
"id": "C0005029",
"name": "benzamides",
"pos": [
20,
30
]
} |
in 181 consecutive records , the most common clinical indications were differentiation of epileptic and nonepileptic events ( 99 ) , seizure recordings for locating a possible focus ( 23 ) , seizure frequency determination ( 32 ) , and investigation of possible trigger factors ( 19 ) . | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
90,
99
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
191,
198
]
} |
iontophoretically applied 2-azido photoaffinity analogues of adenosine 5'-triphosphate ( atp ) and adenosine 5'-monophosphate ( amp ) have been tested on rat cerebral cortical neurons . | NA | {
"id": "C0001480",
"name": "adenosine",
"pos": [
61,
70
]
} | {
"id": "C0001413",
"name": "adenosine 5",
"pos": [
99,
110
]
} |
digoxin and digoxigenin act in a similar manner with a relative potency of ouabain approximately or equal to digoxin greater than digoxigenin . | NA | {
"id": "C0012265",
"name": "digoxin",
"pos": [
0,
7
]
} | {
"id": "C0012264",
"name": "digoxigenin",
"pos": [
130,
141
]
} |
after infiltration of serum lipoproteins , smooth muscle cells become into lipid - loaded foam cells which die . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
28,
40
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
75,
80
]
} |
interrelationships of high-density lipoprotein cholesterol ( c-hdl ) with total plasma cholesterol ( tc ) , triglyceride , and low-density lipoprotein cholesterol , as well as longitudinal maintenance of c-hdl rank order ( tracking ) from birth to age 2 years were assessed in 76 hypercholesterolemic neonates ( cord blood , tc greater than 95 mg/dl ) with focus upon 34 hyperalphalipoproteinemic neonates who had cord blood c-hdl greater than 61 mg/dl , greater than or equal to the 99th percentile . | NA | {
"id": "C0023822",
"name": "high-density lipoprotein cholesterol",
"pos": [
22,
58
]
} | {
"id": "C0008377",
"name": "c-hdl",
"pos": [
425,
430
]
} |
interrelationships of high-density lipoprotein cholesterol ( c-hdl ) with total plasma cholesterol ( tc ) , triglyceride , and low-density lipoprotein cholesterol , as well as longitudinal maintenance of c-hdl rank order ( tracking ) from birth to age 2 years were assessed in 76 hypercholesterolemic neonates ( cord blood , tc greater than 95 mg/dl ) with focus upon 34 hyperalphalipoproteinemic neonates who had cord blood c-hdl greater than 61 mg/dl , greater than or equal to the 99th percentile . | NA | {
"id": "C0023824",
"name": "low-density lipoprotein cholesterol",
"pos": [
127,
162
]
} | {
"id": "C0008377",
"name": "c-hdl",
"pos": [
425,
430
]
} |
[ in vitro activity of cefotaxime against enterobacteriaceae . comparison with cephalothin , cefazolin , cefamandole , cefoxitin and cefuroxime on 117 strains isolated from neutropenic patients ( author 's transl ) ] . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
23,
33
]
} | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
133,
143
]
} |
the in vitro activity of cefotaxime in enterobacteriaceae has been compared to that of cephalothin , cefazolin , cefamandole , cefoxitin and cefuroxime . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
25,
35
]
} | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
141,
151
]
} |
the data were compared with those of 3 other patients with osteoporosis and hypogonadism unconnected with ks . | NA | {
"id": "C0020619",
"name": "hypogonadism",
"pos": [
76,
88
]
} | {
"id": "C0022735",
"name": "ks",
"pos": [
106,
108
]
} |
these results with p. polycephalum in combination with previous studies in non-synchronized rodent cells , suggest that the association of newly replicated dna with the nuclear matrix may be a general feature of eucaryotic dna replication . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
156,
159
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
233,
234
]
} |
inhibition of ellagic acid-activated hageman factor ( factor xii ) and hageman factor fragments by popcorn inhibitor . | NA | {
"id": "C0015527",
"name": "activated hageman factor",
"pos": [
27,
51
]
} | {
"id": "C0015525",
"name": "hageman",
"pos": [
71,
78
]
} |
following short-term administration of estrogens , the concentration of aortic cholesterol was significantly higher in estrogen-treated pigeons with a marked increase in cholesteryl esters . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
79,
90
]
} | {
"id": "C0008387",
"name": "cholesteryl esters",
"pos": [
170,
188
]
} |
no difference was found between the levels of plasminogen activators and antistreptokinase antibodies before and after oral or rectal administration of streptokinase-streptodornase ( varidase ) , nor was there any difference in the hematoma resorption times between patients treated with oral streptokinase and a control group . | NA | {
"id": "C0032144",
"name": "plasminogen",
"pos": [
46,
57
]
} | {
"id": "C0038418",
"name": "streptokinase",
"pos": [
293,
306
]
} |
the electrohydraulic lithotriptor , a machine which breaks up stones by generating a hydraulic shock wave , was assessed as a means of facilitating percutaneous extraction of biliary calculi . | NA | {
"id": "C0006736",
"name": "stones",
"pos": [
62,
68
]
} | {
"id": "C0008350",
"name": "biliary calculi",
"pos": [
175,
190
]
} |
amoxycillin or penicillin g were the first-line drugs for respiratory infection , cotrimoxazole for urinary tract infection and cefalothin or cefacetrile for surgical prophylaxis . | NA | {
"id": "C0007735",
"name": "cefalothin",
"pos": [
128,
138
]
} | {
"id": "C0007714",
"name": "cefacetrile",
"pos": [
142,
153
]
} |
inorganic elements , such as calcium , phosphorus , and magnesium , which have been shown to decrease the intestinal absorption of fluoride in animals were ineffective in man , while aluminum , given as aluminum-containing antacids , markedly decreased the intestinal absorption of fluoride and thereby decreased the retention of fluoride . | NA | {
"id": "C0013879",
"name": "elements",
"pos": [
10,
18
]
} | {
"id": "C0031705",
"name": "phosphorus",
"pos": [
39,
49
]
} |
four new synthetic analogs of vasopressin ( antidiuretic hormone ) can antagonize the antidiuretic response to intravenous vasopressin in anesthetized , water-loaded rats . | NA | {
"id": "C0042413",
"name": "antidiuretic hormone",
"pos": [
44,
64
]
} | {
"id": "C0003779",
"name": "vasopressin",
"pos": [
123,
134
]
} |
radioactive nitrogen-13 from nitrite ( no2- ) or nitrate ( no3- ) administered intratracheally or intravenously without added carrier to mice or rabbits was distributed evenly throughout most organs and tissues regardless of the entry route or the anion administered . | NA | {
"id": "C0028137",
"name": "nitrite",
"pos": [
29,
36
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
248,
253
]
} |
radioactive nitrogen-13 from nitrite ( no2- ) or nitrate ( no3- ) administered intratracheally or intravenously without added carrier to mice or rabbits was distributed evenly throughout most organs and tissues regardless of the entry route or the anion administered . | NA | {
"id": "C0028125",
"name": "nitrate",
"pos": [
49,
56
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
248,
253
]
} |
the injection of vanadate or the hydrolysis-resistant analog of guanosine triphosphate , gtp-gamma-s , into ventral photoreceptors induces the production of discrete waves in the dark . | NA | {
"id": "C0018353",
"name": "guanosine triphosphate",
"pos": [
64,
86
]
} | {
"id": "C0079469",
"name": "gtp-gamma-s",
"pos": [
89,
100
]
} |
the frequency of spondylolysis and spondylolisthesis was determined , as well as that of other spinal abnormalities . | NA | {
"id": "C0038018",
"name": "spondylolysis",
"pos": [
17,
30
]
} | {
"id": "C0038016",
"name": "spondylolisthesis",
"pos": [
35,
52
]
} |
no case of spondylolysis or spondylolisthesis was detected , and when compared to the 5.8 % incidence in the general population , this finding is significant at the p less than 0.001 level . | NA | {
"id": "C0038018",
"name": "spondylolysis",
"pos": [
11,
24
]
} | {
"id": "C0038016",
"name": "spondylolisthesis",
"pos": [
28,
45
]
} |
with the advent of the radioreceptor assay for human chorionic gonadotropin and the radioimmunoassays for the beta subunit of human chorionic gonadotropin , the presence of a positive pregnancy test result may be the most reliable diagnostic aid in helping to recognize early ectopic pregnancy . | NA | {
"id": "C0018062",
"name": "human chorionic",
"pos": [
47,
62
]
} | {
"id": "C0106132",
"name": "beta subunit",
"pos": [
110,
122
]
} |
in previously normal patients in a state of severe shock , a prolongation of partial thromboplastin time above 100 seconds due to shock , an elevation of lactic dehydrogenase above 500 units per milligram , an elevation of serum glutamicoxalacetic transaminase above 125 units per milliliter , an elevation of serum glutamic-pyruvate transaminase above 60 units per milliliter , an elevation of lactate above 52 milligrams per milliliter are grave signs and predict a probable mortality . | NA | {
"id": "C0002594",
"name": "transaminase",
"pos": [
248,
260
]
} | {
"id": "C0001899",
"name": "glutamic-pyruvate transaminase",
"pos": [
316,
346
]
} |
analysis of 24 hour urinary excretion of cortisol , and analyses of 24 hour urinary excretion of epinephrine and norepinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
97,
108
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
113,
127
]
} |
patients in group b , when compared with those of group a , generally had an increase in cortisol secretion as well as in epinephrine and norepinephrine excretion . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
122,
133
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
138,
152
]
} |
studies on the influence of combustion exhaust gases and the products of their reaction with ammonia on the living organism . | NA | {
"id": "C0017110",
"name": "gases",
"pos": [
47,
52
]
} | {
"id": "C0002607",
"name": "ammonia",
"pos": [
93,
100
]
} |
the paper presents the behaviour of dna , rna and soluble proteins in whole homogenate as well as the nuclear , mitochondrial and postmitochondrial liver fractions in guinea pigs exposed to combustion exhaust gases and the products of their reaction with ammonia . | NA | {
"id": "C0017110",
"name": "gases",
"pos": [
209,
214
]
} | {
"id": "C0002607",
"name": "ammonia",
"pos": [
255,
262
]
} |
studies on the influence of combustion exhaust gases and the products of their reaction with ammonia on the living organism . | NA | {
"id": "C0017110",
"name": "gases",
"pos": [
47,
52
]
} | {
"id": "C0002607",
"name": "ammonia",
"pos": [
93,
100
]
} |
blood pressure and mesenteric blood flow were recorded during infusion of biogenic amines ( noradrenaline , dopamine , serotonin , acetylcholine and histamine ) . | NA | {
"id": "C0005496",
"name": "biogenic amines",
"pos": [
74,
89
]
} | {
"id": "C0001041",
"name": "acetylcholine",
"pos": [
131,
144
]
} |
the fact that in vivo methylene diphosphonic acid in a dose having an immuno-depressive action has no influence on the activity of glucose-6-phosphatase dehydrogenase in the lymphoid organs , may evidence for the absence of the indirect immunodepressive effect of diphosphonate by affecting this enzyme . | NA | {
"id": "C0066351",
"name": "methylene",
"pos": [
22,
31
]
} | {
"id": "C0012544",
"name": "diphosphonate",
"pos": [
264,
277
]
} |
this study describes an experimental model for the investigation of nephrotoxicity in which the aminoglycoside , gentamicin , is given after unilateral ureteral obstruction is produced . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
96,
110
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
113,
123
]
} |
there were found some specific features of the clinico-morphological picture of the neoplastic process in question : slow development , a predominant peripheral tumor growth , large size tumors , less pronounced local invasion of dimorphous cancer , comparatively rare metastases ( 34.8 % ) . | NA | {
"id": "C0027671",
"name": "neoplastic process",
"pos": [
84,
102
]
} | {
"id": "C0027627",
"name": "metastases",
"pos": [
269,
279
]
} |
the main component of the thyroid colloid was 19s thyroglobulin ( tg ) , but larger iodoproteins ( s-tg ) and smaller protein fractions , an albumin-like protein and a pre-albumin fraction , were also present in varying relative amounts . | NA | {
"id": "C0021989",
"name": "iodoproteins",
"pos": [
84,
96
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
154,
161
]
} |
the main component of the thyroid colloid was 19s thyroglobulin ( tg ) , but larger iodoproteins ( s-tg ) and smaller protein fractions , an albumin-like protein and a pre-albumin fraction , were also present in varying relative amounts . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
88,
95
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
172,
179
]
} |
foetal and maternal plasma adrenaline and noradrenaline concentrations in the late pregnant rat : effects of intra-uterine isotonic saline or uterine handling . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
27,
37
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
42,
55
]
} |
the catecholamines adrenaline ( a ) and noradrenaline ( na ) were determined in plasma samples of late pregnant rats and rat foetuses using a radioenzymatic procedure . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
19,
29
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
40,
53
]
} |
morphometric analysis of secretory granules was performed in 16 chromophobe adenomas : seven undifferentiated cell adenomas ( group a ) , two of which were accompanied by mild hyperprolactinemia and nine prolactin cell sparsely granulated adenomas ( group b ) , all associated with hyperprolactinemia . | NA | {
"id": "C0001432",
"name": "chromophobe",
"pos": [
64,
75
]
} | {
"id": "C0001430",
"name": "adenomas",
"pos": [
239,
247
]
} |
morphometric analysis of secretory granules was performed in 16 chromophobe adenomas : seven undifferentiated cell adenomas ( group a ) , two of which were accompanied by mild hyperprolactinemia and nine prolactin cell sparsely granulated adenomas ( group b ) , all associated with hyperprolactinemia . | NA | {
"id": "C0001430",
"name": "adenomas",
"pos": [
76,
84
]
} | {
"id": "C0033375",
"name": "prolactin cell",
"pos": [
204,
218
]
} |
on this basis , we believe that ( a ) cerebral astrocytomas have a characteristic behavior in vitro and ( b ) the glioblastoma is an astrocytic tumor showing maximal dedifferentiation . | NA | {
"id": "C0017636",
"name": "glioblastoma",
"pos": [
114,
126
]
} | {
"id": "C0004114",
"name": "astrocytic tumor",
"pos": [
133,
149
]
} |
concentrations of progesterone ( p ) , 20 alpha-dihydroprogesterone ( 20p ) , 17-hydroxyprogesterone ( 17p ) , androstenedione ( a ) , estrone ( e1 ) estradiol ( e2 ) in endometrium and peripheral blood taken simultaneously from normally menstruating women in the course of hysterectomy were determined by radioimmunological assay . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
18,
30
]
} | {
"id": "C0012311",
"name": "20 alpha-dihydroprogesterone",
"pos": [
39,
67
]
} |
concentrations of progesterone ( p ) , 20 alpha-dihydroprogesterone ( 20p ) , 17-hydroxyprogesterone ( 17p ) , androstenedione ( a ) , estrone ( e1 ) estradiol ( e2 ) in endometrium and peripheral blood taken simultaneously from normally menstruating women in the course of hysterectomy were determined by radioimmunological assay . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
18,
30
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
78,
100
]
} |
from the growth pattern of uterine fundal length and bpd , intrauterine growth retardation ( iugr ) in pregnancy with eph-gestosis occurred mainly within the third trimester of pregnancy . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
103,
112
]
} | {
"id": "C0032981",
"name": "third trimester",
"pos": [
158,
173
]
} |
acute pancreatitis verified at laparotomy occurred in the 37th week in 1 of 4 women who developed excessive hypertriglyceridemia ( type v hyperlipoproteinemia ) during pregnancy . | NA | {
"id": "C0020557",
"name": "hypertriglyceridemia",
"pos": [
108,
128
]
} | {
"id": "C0020481",
"name": "type v hyperlipoproteinemia",
"pos": [
131,
158
]
} |
the long-term ocular and systemic effects of topically applied metoprolol tartrate in glaucoma and ocular hypertension . | NA | {
"id": "C0017601",
"name": "glaucoma",
"pos": [
86,
94
]
} | {
"id": "C0028840",
"name": "ocular hypertension",
"pos": [
99,
118
]
} |
ten patients with ocular hypertension or glaucoma were treated over 4 months with the betablocker metoprolol tartrate as 3 % eye drops twice daily . | NA | {
"id": "C0028840",
"name": "ocular hypertension",
"pos": [
18,
37
]
} | {
"id": "C0017601",
"name": "glaucoma",
"pos": [
41,
49
]
} |
the subjects in whom pre-beta 1-lipoprotein was present exhibited a significantly delayed early insulin response compared to subjects without this lipoprotein fraction . | NA | {
"id": "C0023825",
"name": "pre-beta",
"pos": [
21,
29
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
147,
158
]
} |
in the neural lobe , peptide hormones from magnocellular neurons are stored and released into the general circulation in the median eminence , releasing and inhibiting hormones enter the hypothalamo-adenohypophyseal portal circulation . | NA | {
"id": "C0597192",
"name": "peptide hormones",
"pos": [
21,
37
]
} | {
"id": "C0019932",
"name": "hormones",
"pos": [
168,
176
]
} |
a variety of neuropeptides , such as trh , somatostatin , vip , substance p , neurotensin , cck , gastrin , and opioid peptides , alter secretion of gh and prl from the pituitary . | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
13,
26
]
} | {
"id": "C0027930",
"name": "neurotensin",
"pos": [
78,
89
]
} |
a variety of neuropeptides , such as trh , somatostatin , vip , substance p , neurotensin , cck , gastrin , and opioid peptides , alter secretion of gh and prl from the pituitary . | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
13,
26
]
} | {
"id": "C0205753",
"name": "opioid peptides",
"pos": [
112,
127
]
} |
the transferrins are iron-binding proteins with molecular weights of around 80,000 , which interact with a maximum of two ferric atoms per each protein molecule . | NA | {
"id": "C3202973",
"name": "transferrins",
"pos": [
4,
16
]
} | {
"id": "C1135611",
"name": "iron-binding proteins",
"pos": [
21,
42
]
} |
10 patients with coronary artery disease ( cad ) ( group 2 ) , 12 patients with severe obstructive lung disease ( copd ) ( group 3 ) , and eight patients with both cad and copd ( group 4 ) by gated equilibrium radionuclide angiography . | NA | {
"id": "C0600260",
"name": "obstructive lung disease",
"pos": [
87,
111
]
} | {
"id": "C0024117",
"name": "copd",
"pos": [
172,
176
]
} |
seven dogs were resuscitated from vf during coronary ligation and all seven suffered vf on reperfusion , whereas 37 dogs were arrhythmia-free during ligation and only one ( 3 % , p less than 0.001 ) had vf on reperfusion . | NA | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
126,
136
]
} | {
"id": "C0042510",
"name": "vf",
"pos": [
203,
205
]
} |
we conclude that exercise-induced regional wall motion abnormalities are not reliable for the detection of coronary artery disease in patients with valvular heart disease . | NA | {
"id": "C0018799",
"name": "the",
"pos": [
90,
93
]
} | {
"id": "C0018824",
"name": "valvular heart disease",
"pos": [
148,
170
]
} |
the stomach content of the nucleotide in rat pups remained high for at least 1 h after suckling indicating that cyclic nucleotides remain available for intestinal absorption ; | NA | {
"id": "C0028630",
"name": "nucleotide",
"pos": [
27,
37
]
} | {
"id": "C0028631",
"name": "cyclic nucleotides",
"pos": [
112,
130
]
} |
plasma amino acid concentrations and the ratios of tryptophan and tyrosine to other large neutral amino acids ( naa ) were related to prior food consumption by normal healthy adults and by adults with hepatic encephalopathy . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
7,
17
]
} | {
"id": "C0301715",
"name": "neutral amino acids",
"pos": [
90,
109
]
} |
human milk samples obtained from 1436 women residing in the united states were analyzed by gas-liquid chromatography for the chlorinated hydrocarbon insecticides -- dieldrin , chlordane , heptachlor , heptachlor epoxide , oxychlordane and mirex . | NA | {
"id": "C0019219",
"name": "heptachlor",
"pos": [
188,
198
]
} | {
"id": "C0019220",
"name": "heptachlor epoxide",
"pos": [
201,
219
]
} |
although heptachlor was recovered in less than 2 % of the samples , its metabolite , heptachlor epoxide , was found above the detection limit in 63 % of the samples . | NA | {
"id": "C0019219",
"name": "heptachlor",
"pos": [
9,
19
]
} | {
"id": "C0019220",
"name": "heptachlor epoxide",
"pos": [
85,
103
]
} |
material cross-reacting with antibodies to acid lipase was demonstrated in fibroblasts of three patients with wolman disease and three with cholesterol ester storage disease . | NA | {
"id": "C0043208",
"name": "wolman disease",
"pos": [
110,
124
]
} | {
"id": "C0008384",
"name": "cholesterol",
"pos": [
140,
151
]
} |
crm specific activity toward triolein and cholesteryl oleate was reduced about 200-fold in the wolman disease fibroblasts and 50- to 100-fold in the cholesterol ester storage disease cells when compared to normal . | NA | {
"id": "C0043208",
"name": "wolman disease",
"pos": [
95,
109
]
} | {
"id": "C0008384",
"name": "cholesterol ester storage disease",
"pos": [
149,
182
]
} |
although metabolism may play a role in the disposition of cefaclor , elimination is primarily renal . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
9,
19
]
} | {
"id": "C0221102",
"name": "elimination",
"pos": [
69,
80
]
} |
cefaclor 's spectrum of activity is similar to that of cefalexin , including a wide range of gram-negative and gram-positive bacteria ; | NA | {
"id": "C0007537",
"name": "cefaclor 's",
"pos": [
0,
11
]
} | {
"id": "C0007716",
"name": "cefalexin",
"pos": [
55,
64
]
} |
in particular , escherichia coli , klebsiella spp. , proteus mirabilis , salmonella spp. , and haemophilus influenzae are more susceptible to clinically achievable concentrations of cefaclor than cephalexin . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
182,
190
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
196,
206
]
} |
we have investigated the effects of six weeks of treatment with the sulfonylurea agents gliclazide and glyburide on platelet aggregation in 10 noninsulin-dependent diabetic subjects . | NA | {
"id": "C0038766",
"name": "sulfonylurea",
"pos": [
68,
80
]
} | {
"id": "C0017631",
"name": "gliclazide",
"pos": [
88,
98
]
} |
we have investigated the effects of six weeks of treatment with the sulfonylurea agents gliclazide and glyburide on platelet aggregation in 10 noninsulin-dependent diabetic subjects . | NA | {
"id": "C0038766",
"name": "sulfonylurea",
"pos": [
68,
80
]
} | {
"id": "C0017628",
"name": "glyburide",
"pos": [
103,
112
]
} |
to investigate the mechanism of pharmacodynamic tolerance reported to occur during prazosin therapy of chronic congestive heart failure , we measured plasma norepinephrine , plasma epinephrine , plasma renin activity ( pra ) and plasma aldosterone , as well as hemodynamics in eight patients with chronic congestive heart failure , functional class iii and iv ( nyha ) , before and during 10 weeks of prazosin therapy . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
157,
171
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
181,
192
]
} |
initially , prazosin therapy produced significant hemodynamic improvement , but no significant changes were noted in norepinephrine , epinephrine , plasma renin activity or aldosterone . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
117,
131
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
134,
145
]
} |
following treatment with acyclovir ( 19- ( 2-hydroxyethoxymethyl ) guanine ) , this patient had a rapid remission of these viral infections . | NA | {
"id": "C0001367",
"name": "acyclovir",
"pos": [
25,
34
]
} | {
"id": "C0018321",
"name": "guanine",
"pos": [
67,
74
]
} |
circulating concentrations of specific placental proteins ( human chorionic gonadotropin , pregnancy-specific beta-1 glycoprotein , and placental protein 5 ) in untreated gestational trophoblastic tumors . | NA | {
"id": "C0032974",
"name": "placental proteins",
"pos": [
39,
57
]
} | {
"id": "C0033002",
"name": "pregnancy-specific beta-1 glycoprotein",
"pos": [
91,
129
]
} |
the pathophysiologic findings suggested a photosensitivity reaction in sites of uroporphyrin and 7-carboxyl porphyrin deposition . | NA | {
"id": "C0042093",
"name": "uroporphyrin",
"pos": [
80,
92
]
} | {
"id": "C0032712",
"name": "porphyrin",
"pos": [
108,
117
]
} |
an immunoperoxidase study of normal , megaloblastic , and dysplastic erythropoiesis , including erythroleukemia and other myeloproliferative disorders . | NA | {
"id": "C0023440",
"name": "erythroleukemia",
"pos": [
96,
111
]
} | {
"id": "C0027022",
"name": "myeloproliferative",
"pos": [
122,
140
]
} |
using an immunoperoxidase indirect sandwich technique for detection of intracellular hemoglobin , erythroid cells at all stages of maturation were readily identified in bone marrow biopsies ( 58 specimens total ) with a ) normal erythropoiesis , b ) megalobastic erythropoiesis , and c ) various myeloproliferative disorders , including erythroleukemia . | NA | {
"id": "C0027022",
"name": "myeloproliferative disorders",
"pos": [
296,
324
]
} | {
"id": "C0023440",
"name": "erythroleukemia",
"pos": [
337,
352
]
} |
type iv nuclear bodies were most commonly seen in the epithelial cells of proximal tubules but were also seen occasionally in interstitial fibroblasts and cells of a collecting duct and a developing crescent . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
139,
150
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
155,
160
]
} |
at 4 degrees c animals fasted for 2 days excreted 29 % less norepinephrine ( ne ) than fed animals , averaging 458 +/- 32ng ne/mg creatinine and 646 +/- 68 , respectively ( p less than 0.005 ) , but 122 % more epinephrine ( e ) 77.9 +/- 11.7 ng e/mg creatinine and 35.1 +/- 6.7 , respectively ( p less than .01 ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
60,
74
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
210,
221
]
} |
it is possible , however , that there exist in the antiserum heterogeneous antibodies that bind to nonreceptor sites on the plasma membrane and mediate some of the phenomena observed . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
51,
60
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
75,
85
]
} |
graded physiological doses of norepinephrine or epinephrine were infused either intravenously or directly into the renal artery of conscious dogs previously prepared with chronic indwelling catheters . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
30,
44
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
48,
59
]
} |
the concentrations of norepinephrine or epinephrine required to alter urinary sodium and potassium excretion and flow rate were in the upper physiological range or higher and the responses were small except for intravenous epinephrine , which decreased sodium excretion at very low physiological concentrations ( 120-400 pg/ml ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
22,
36
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
223,
234
]
} |
the potential significance of ionized species in weak electrolyte absorption or secretion has been reexamined using a mathematical model that represents the epithelium as a system of parallel ion-permeable and ion-impermeable channels . | NA | {
"id": "C0013832",
"name": "electrolyte",
"pos": [
54,
65
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
210,
213
]
} |
with occlusions exceeding 20 min there was persistence of systolic passive lengthening for 6 h despite the absence of infarction in the segment lengths in which function was being evaluated , although infarcted tissue was present ranging from 16.5 +/- 2.6 % of the area of ischemia in dogs with 60-min coronary occlusions to 37.2 +/- 4.6 % of the area of ischemia in dogs with 120-min occlusions . | NA | {
"id": "C0021308",
"name": "infarction",
"pos": [
118,
128
]
} | {
"id": "C0022116",
"name": "ischemia",
"pos": [
355,
363
]
} |
the effects of prostaglandins ( pge2 and 16,16-dimethyl-pge1 ) on epinephrine ( e ) and norepinephrine ( ne ) release , in response to a hypotensive stimulus ( bleeding 5 ml/300 g ) , were studied in relation to blood pressure and heart rate responses in the rat . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
66,
77
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
88,
102
]
} |
the glucose replacement rate , plasma glucose concentration , glucose body mass , and amino acid gluconeogenesis were determined in vivo in fed and fasted kelp bass ( paralabrax clathratus ) using [ 6-3h ] glucose administered with [ u-14c ] glutamate , [ u-14c ] aspartate , or [ u-14c ] alanine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
86,
96
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
289,
296
]
} |
is he or she to concentrate in objective-descriptive fashion , observing symptoms and signs , seeking the likely syndrome or disease concept ? | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
113,
121
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
125,
132
]
} |
electron microscopic examination of stools of 702 infants and young children hospitalized in the emergency service of the alejandro mann children 's hospital in guayaquil , ecuador , between august 1978 and october 1979 showed rotavirus to be present in 148 ( 21.1 % ) . | NA | {
"id": "C0728836",
"name": "young children",
"pos": [
62,
76
]
} | {
"id": "C0008059",
"name": "children 's",
"pos": [
137,
148
]
} |
these findings indicated that histamine and serotonin were released from the edematous tissue and that circulation improved through increased output of adrenaline and noradrenaline . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
152,
162
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
167,
180
]
} |
increased efforts must be made to diagnose sepsis early and drain any collections of pus , particularly in anergic patients who may show little or no evidence of sepsis even after the development of multiple organ failure or shock . | NA | {
"id": "C0026766",
"name": "multiple organ failure",
"pos": [
199,
221
]
} | {
"id": "C0036974",
"name": "shock",
"pos": [
225,
230
]
} |
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