text
stringlengths 57
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stringclasses 125
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dict | t
dict |
|---|---|---|---|
compounds with an oxazolidine ring had approximately similar affinities for the [ 3h ] clonidine binding sites compared with the corresponding imidazolines ( except for the 2,6-dichlorophenyl-substituted compound ) whereas the pyrrolidine derivatives showed a 10-fold weaker affinity . | NA | {
"id": "C0009014",
"name": "clonidine",
"pos": [
87,
96
]
} | {
"id": "C1449836",
"name": "imidazolines",
"pos": [
143,
155
]
} |
it is suggested that although the high oxygen affinity hemoglobins ( hb lr ) ( beta 143 ( h21 ) his leads to gln ) with stabilization of r quaternary conformation is not more susceptible to the oxidizing effect of nitrites in vitro , in an in vivo situation where hemoglobin is partly deoxygenated , it might be more susceptible to methemoglobin formation due to higher oxidation and lower reduction rate . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
55,
65
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
332,
345
]
} |
a new schedule of combined treatment with bromocriptine and clomiphene citrate was applied to 23 patients with normoprolactinemic amenorrhea who failed to respond to clomiphene alone . | NA | {
"id": "C0546859",
"name": "clomiphene citrate",
"pos": [
60,
78
]
} | {
"id": "C0009008",
"name": "clomiphene",
"pos": [
166,
176
]
} |
in a survey of literature concerning 548 patients , delta prl after trh administration amounted to 100 % or more of the basal value in 11 % of patients with clinical evidence of a prolactinoma and in 9 % with an adenoma proven by surgery . | NA | {
"id": "C0033375",
"name": "prolactinoma",
"pos": [
180,
192
]
} | {
"id": "C0001430",
"name": "adenoma",
"pos": [
212,
219
]
} |
whenever male infertility is resistant to therapy , artificial donor insemination ( aid ) may be employed as a very efficient tool to provide the infertile couple with the desired child . | NA | {
"id": "C0021364",
"name": "male infertility",
"pos": [
9,
25
]
} | {
"id": "C0021359",
"name": "infertile",
"pos": [
146,
155
]
} |
more recently we have observed in seminal plasma a soluble component that has a typical spectrum of a reduced cytochrome b , but can be distinguished from the b-type cytochromes in other mammalian tissue . | NA | {
"id": "C0010798",
"name": "cytochrome",
"pos": [
110,
120
]
} | {
"id": "C1256751",
"name": "b-type cytochromes",
"pos": [
159,
177
]
} |
gc monolayers after 48 h with or without fsh and te converted [ 3h ] cholesterol into 4 major metabolites , 3 of which were secreted into the medium and , in thin-layer chromatographic behavior , resembled pregnenolone , progesterone and 20 alpha-dihydroprogesterone . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
221,
233
]
} | {
"id": "C0012311",
"name": "20",
"pos": [
238,
240
]
} |
binding of thyrotropin-releasing hormone ( trh , thyroliberin ) to receptors in chilled membrane resuspensions from sheep anterior pituitary glands is reduced in affinity almost 2-fold by micromolar concentrations of guanosine 5'-triphosphate ( gtp ) and the hydrolysis-resistant analog guanyl-5'-yl imidodiphosphate ( gppnhp ) added to tissue during a 10-min preincubation at 37 degree c . | NA | {
"id": "C0018353",
"name": "guanosine",
"pos": [
217,
226
]
} | {
"id": "C0018366",
"name": "guanyl-5",
"pos": [
287,
295
]
} |
dextrose ingestion led to a higher initial blood glucose increase than did the mixed meal , but the duration of blood glucose increase lasted significantly longer after the mixed meal than after the dextrose load . | NA | {
"id": "C0005802",
"name": "blood",
"pos": [
43,
48
]
} | {
"id": "C0017725",
"name": "dextrose",
"pos": [
199,
207
]
} |
antibodies from five of the cell lines by radioimmunoassay react significantly with cultured rat fibroblasts in addition to their reaction with rin cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
97,
108
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
148,
153
]
} |
this study demonstrates the feasibility of producing monoclonal antibodies to islet cell differentiation antigens and describes several antibodies which should be useful reagents in studies of the physiology and pathophysiology of the islet cell plasma membrane . | NA | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
53,
63
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
136,
146
]
} |
the dominant effect of the proteolytic enzymes was to incompletely degrade the major membrane protein ( mol . wt . 28,000 ) , with the appearance of new protein ( mol . wt . 20,000 ) . | NA | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
85,
101
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
153,
160
]
} |
the in vivo effects of vasoactive intestinal polypeptide ( vip ) , secretin and two different molecular forms of gastrin , gastrin 17 and pentagastrin , on basal and stimulated insulin secretion have been investigated in the mouse . | NA | {
"id": "C0017151",
"name": "gastrin",
"pos": [
113,
120
]
} | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
138,
150
]
} |
neither the diabetic group on diet alone nor the insulin-treated group differed significantly from control subjects with respect to lipid and lipoprotein concentrations . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
132,
137
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
142,
153
]
} |
in dogs with gastric and pancreatic thomas fistulas the effect of different cholecystokinin-like peptides upon pancreatic polypeptide ( pp ) release was studied in three ways : ( a ) plasma pp concentrations were determined by radioimmunoassay in response to 135 pmol/kg/h of the synthetic c-terminal octapeptide of cholecystokinin ( cck-op ) ( a ) , of three of its analogues ( b , c , d ) where methionine has been replaced by methoxinine , and in response to 45 pmol/kg/h of caerulein . | NA | {
"id": "C0008328",
"name": "cholecystokinin",
"pos": [
76,
91
]
} | {
"id": "C0037167",
"name": "cck-op",
"pos": [
334,
340
]
} |
these results support the concept that in jejunal mucosa of children , d-xylose is at least in part , transported by a system that is different from those for fructose and na-dependent d-glucose ( hexose ) transport . | NA | {
"id": "C0016745",
"name": "fructose",
"pos": [
159,
167
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
197,
203
]
} |
these results support the concept that in jejunal mucosa of children , d-xylose is at least in part , transported by a system that is different from those for fructose and na-dependent d-glucose ( hexose ) transport . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
187,
194
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
197,
203
]
} |
we report a case of a man previously exposed to sulfamethoxazole-trimethoprim who died of liver failure following subsequent ingestion of only two tablets of the drug ( 160 mg trimethoprim and 800 mg sulfamethoxazole ) . | NA | {
"id": "C0041044",
"name": "sulfamethoxazole-trimethoprim",
"pos": [
48,
77
]
} | {
"id": "C0038689",
"name": "sulfamethoxazole",
"pos": [
200,
216
]
} |
unsaturated fatty acids ( fa ) were bound to human albumin in a molar ratio of 2 and were then added to platelet-rich plasma ( prp ) , increasing the total fa concentration by 1 mm . | NA | {
"id": "C0015690",
"name": "unsaturated fatty acids",
"pos": [
0,
23
]
} | {
"id": "C0015684",
"name": "fa",
"pos": [
156,
158
]
} |
sulphide , sulphite and thiosulphate are oxidized to sulphate at a maximal rate at the beginning of the reaction , oxidation of elemental sulphur exhibits a lag phase . | NA | {
"id": "C0039950",
"name": "thiosulphate",
"pos": [
24,
36
]
} | {
"id": "C0038720",
"name": "sulphate",
"pos": [
53,
61
]
} |
we studied pulmonary tissue from seven men employed in the mining and milling of talc that contained minimal amounts of crystalline silica and asbestiform minerals . | NA | {
"id": "C0037098",
"name": "silica",
"pos": [
132,
138
]
} | {
"id": "C0026162",
"name": "minerals",
"pos": [
155,
163
]
} |
nodular transformation , a rare hyperplastic condition of the liver , has been reported in patients with rheumatoid arthritis , felty 's syndrome , the crst syndrome , and myeloproliferative disorders . | NA | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
105,
125
]
} | {
"id": "C0015773",
"name": "felty 's syndrome",
"pos": [
128,
145
]
} |
the light microscopic features were typical , and ultrastructural examination confirmed the presence of pericyte-like cells and excluded smooth muscle and fibroblastic differentiation . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
118,
123
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
155,
167
]
} |
the effect of iron on the mlr was examined by pretreating peripheral blood mononuclear cells from 77 unrelated caucasians with five concentrations of ferric-citrate ( 10.0 mm , 1.0 mm , 0.1 mm , 0.01 mm and 0.005 mm ) . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
14,
18
]
} | {
"id": "C0060231",
"name": "ferric-citrate",
"pos": [
150,
164
]
} |
insulin-dependent diabetes mellitus ( iddm ) has been found to be highly associated with a rare allele of the complement protein , properdin factor b ( bf ) . | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
110,
120
]
} | {
"id": "C0033453",
"name": "properdin factor b",
"pos": [
131,
149
]
} |
the influence of the b complex component on genetic susceptibility is more visible in animals with limited susceptibility at other loci and becomes indistinguishable as the frequency of other genes determining thyroid autoimmunity increases . | NA | {
"id": "C0314657",
"name": "genetic susceptibility",
"pos": [
44,
66
]
} | {
"id": "C0012655",
"name": "susceptibility",
"pos": [
107,
121
]
} |
absorption analysis demonstrated that the antisera were complex , and contained several new antibodies including some which were not cytotoxic , but could be detected by rosetting . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
42,
50
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
92,
102
]
} |
in contrast to hybrids with pseudodiploid alv-induced lymphomas , hybrids between thy 1.1+ lymphomas and pseudotetraploid thy 1.2- abelson-leukemia-virus-induced lymphomas do not express thy-1 glycoprotein on their cell surface and thy-1 glycoprotein can not be detected in detergent extracts of these cells . | NA | {
"id": "C0025248",
"name": "glycoprotein",
"pos": [
193,
205
]
} | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
238,
250
]
} |
these studies are based on our previous observation tht aldosterone enhances the biosynthesis of renal flavin mononucleotide ( fmn ) and flavin adenine dinucleotide ( fad ) from riboflavin , and that fmi and hei competitively inhibit conversion of riboflavin to fmn and reabsorption of na+ in the kidney of adrenalectomized rats . | NA | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
178,
188
]
} | {
"id": "C0016388",
"name": "fmn",
"pos": [
262,
265
]
} |
compared with nk cells , the in vitro-generated killer cells with nk-like reactivity were slightly adherent to nylon wool fibers , a little more sensitive to anti-thyl.2 antibody plus complement and almost entirely resistant to cytotoxic treatment with anti-asialo gm1 antiserum which is selectively cytotoxic to nk cells . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
170,
178
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
269,
278
]
} |
the pharmacokinetics of amitryptyline ( ami ) have been evaluated in six healthy elderly volunteers ( 72-83 years of age ) after a single dose of 125 mg of ami-hcl . | NA | {
"id": "C0002600",
"name": "amitryptyline",
"pos": [
24,
37
]
} | {
"id": "C0700523",
"name": "ami-hcl",
"pos": [
156,
163
]
} |
ten kidney tumors conforming to nephroblastoma were encountered during a 10-year period in a closed colony of nb hooded rats . | NA | {
"id": "C0022665",
"name": "kidney tumors",
"pos": [
4,
17
]
} | {
"id": "C0027708",
"name": "nephroblastoma",
"pos": [
32,
46
]
} |
the lowered levels of some amino acids ( e.g. , alanine , glutamine , glutamate ) seem to suggest that amino acid catabolism and/or gluconeogenesis is increased by exercise . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
27,
38
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
48,
55
]
} |
glucose feeding resulted in a rapid increase in blood glucose , with attainment of peak hyperglycemia within 1 h and of peak muscle glycogen in about 2 h . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
0,
7
]
} | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
48,
61
]
} |
blood glucose and muscle glycogen increased slowly in the glycerol-fed rats and peaked much later than after glucose feeding . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
0,
13
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
109,
116
]
} |
these results suggest that branched chain alpha-keto acid dehydrogenase activity , which is thought to limit the rate of branched chain amino acid oxidation in adipose tissue , may be sensitive to changes in the concentration of leucine in rat blood . | NA | {
"id": "C0002521",
"name": "branched",
"pos": [
27,
35
]
} | {
"id": "C0023401",
"name": "leucine",
"pos": [
229,
236
]
} |
these data represent the first chemical evidence for the existence of an evolutionary relationship among anaphylatoxins c3a , c4a , and c5a , and imply that a similar relationship exists among their precursor proteins . | NA | {
"id": "C0002791",
"name": "anaphylatoxins",
"pos": [
105,
119
]
} | {
"id": "C0009510",
"name": "c3a",
"pos": [
120,
123
]
} |
studies with the synthetic gtp analogue , gtp gamma s , suggest that gtp hydrolysis is required for this 41 protein movement , but that it is not essential for the function of the 41 protein in rna primer synthesis . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
27,
30
]
} | {
"id": "C0079469",
"name": "gtp gamma s",
"pos": [
42,
53
]
} |
by blocking this gtpase activity with the synthetic gtp analogue , gtp gamma s , we show that limited rna primer synthesis can occur without this nucleotide hydrolysis by the 41 protein , but that prolonged rna primer synthesis requires such hydrolysis . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
17,
20
]
} | {
"id": "C0079469",
"name": "gtp gamma s",
"pos": [
67,
78
]
} |
the differential mobilities of empty carrier and carrier loaded with these hexoses and the efficiency of their transport were equivalent to those observed with 3-o-methylglucose , but the michaelis-menten constants for the transport of d-galactose and d-glucosamine were 5-8-fold higher than those for d-glucose , 2-deoxy-d-glucose , and 3-o-methylglucose , which were about equivalent . | NA | {
"id": "C0019494",
"name": "hexoses",
"pos": [
75,
82
]
} | {
"id": "C0016945",
"name": "galactose",
"pos": [
238,
247
]
} |
studies in which the formation of individual gamma-glutamyl amino acids was determined in the presence of glutathione and the amino acid mixture showed that l-cystine and l-glutamine are the most active amino acid acceptors , and that other neutral amino acids also participate in transpeptidation to a significant extent . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
60,
70
]
} | {
"id": "C0301715",
"name": "neutral",
"pos": [
241,
248
]
} |
the participation of sterol carrier protein2 in the conversion of cholesterol to cholesterol ester by rat liver microsomes . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
66,
77
]
} | {
"id": "C0008387",
"name": "cholesterol ester",
"pos": [
81,
98
]
} |
the reaction studied in the present investigation was the conversion of cholesterol to cholesterol ester ( acyl-coa cholesterol acyltransferase ) by rat liver microsomes . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
72,
83
]
} | {
"id": "C0008387",
"name": "cholesterol ester",
"pos": [
87,
104
]
} |
the results show that when exogenously added [ 4-14c ] cholesterol is the substrate , scp2 produces a striking increase in cholesterol ester biosynthesis by rat liver microsomes . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
55,
66
]
} | {
"id": "C0008387",
"name": "cholesterol ester",
"pos": [
123,
140
]
} |
although the effect of scp2 was most clearly seen with exogenously added cholesterol , it was also demonstrated when [ 1-14c ] oleoyl-coa was the labeled substrate and the incorporation of labeled oleate into cholesterol ester was determined . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
73,
84
]
} | {
"id": "C0008387",
"name": "cholesterol ester",
"pos": [
209,
226
]
} |
the results demonstrate that scp2 participates in the utilization of cholesterol via the microsomal conversion of cholesterol to cholesterol ester . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
69,
80
]
} | {
"id": "C0008387",
"name": "cholesterol ester",
"pos": [
129,
146
]
} |
evidence that the highly dynamic protein of the purified membranes is indeed membrane protein is provided by the observations indicating : that this protein is immunochemically distinct from serum proteins , which are the major secretory product of liver ; | NA | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
77,
93
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
197,
204
]
} |
the production of procollagen molecules by human diploid fetal lung fibroblasts ( hfl-1 cells ) remains constant in both rapid and stationary growth phases . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
68,
79
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
88,
93
]
} |
therefore , the ability of hfl-1 cells to maintain constant collagen production irrespective of the growth status of the cells results from the combined action of a number of regulatory mechanisms , including changes in procollagen mrna levels , the utilization of procollagen mrna , and intracellular procollagen degradation . | NA | {
"id": "C0009325",
"name": "collagen",
"pos": [
60,
68
]
} | {
"id": "C0033235",
"name": "procollagen",
"pos": [
302,
313
]
} |
the electron microscopic appearance of the biotinated mac hybrid closely resembled that of the characteristic membrane lesions of complement lysed cells . | NA | {
"id": "C0009545",
"name": "mac",
"pos": [
54,
57
]
} | {
"id": "C0009498",
"name": "complement",
"pos": [
130,
140
]
} |
required active myeloperoxidase , micromolar concentrations of h2o2 ( or glucose oxidase as a peroxide generator ) , and a halide cofactor ( cl- or i- ) ; | NA | {
"id": "C0020281",
"name": "h2o2",
"pos": [
63,
67
]
} | {
"id": "C0031180",
"name": "peroxide",
"pos": [
94,
102
]
} |
the vmax of factor xa formation slightly increases when more phospholipid is present in our experiments , and there is a considerable increase of the km for factor x at higher phospholipid concentrations . | NA | {
"id": "C0015520",
"name": "factor xa",
"pos": [
12,
21
]
} | {
"id": "C0015518",
"name": "factor x",
"pos": [
157,
165
]
} |
between 75 and 90 % of the peroxide produced results from dismutation of superoxide formed as an intermediate . | NA | {
"id": "C0031180",
"name": "peroxide",
"pos": [
27,
35
]
} | {
"id": "C0038836",
"name": "superoxide",
"pos": [
73,
83
]
} |
extent and specificity of cell adhesion triggered by carbohydrate-reactive proteins ( glycosidases and lectins ) and by fibronectin . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
75,
83
]
} | {
"id": "C0023206",
"name": "lectins",
"pos": [
103,
110
]
} |
the extent and the specificity of the initial cell attachment induced by various proteins coated on plastic surfaces have been studied with the following results : ( a ) cell adhesion on the surfaces coated with sialidase and beta-galactosidase was as strong as on concanavalin a and limulus lectin-coated surfaces and the reactions were strongly inhibited by glycosidase inhibitors or by competitive substrates . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
81,
89
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
292,
298
]
} |
the occurrence of alpha-mannosidase activity at the surface of hamster embryo ( nil ) fibroblasts is indicated by the following findings : ( a ) when nil cells were incubated on the glass surfaces on which ovalbumin glycopeptides were covalently linked , a rapid release of free mannose from ovalbumin glycopeptides was observed as evidenced by analysis on gas chromatography/mass spectrometry . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
86,
97
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
154,
159
]
} |
high inhibitory activity of the mannan polysaccharide and of ovalbumin favored the presence of the mannosidase activity at the cell surface , as these substrates may not penetrate rapidly into the cells . | NA | {
"id": "C0024727",
"name": "mannan",
"pos": [
32,
38
]
} | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
39,
53
]
} |
the following findings indicated that the cell surface mannosidase is mediating the cell adhesion based on the recognition of high-mannose-type glycopeptide : ( a ) ovalbumin- coated plastic surfaces strongly promoted attachment and spreading of nil fibroblasts , whereas the same ovalbumin coat did not promote attachment and spreading of some other cell types ( balb/c 3t3 fibroblasts and freshly prepared rat liver cells ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
250,
261
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
418,
423
]
} |
the interpretation that the cell surface mannosidase is able to mediate cell adhesion is in agreement with previous studies suggesting that polyvalent glycosidase surfaces can promote cell adhesion to a degree similar to that caused by fibronectin and several lectins by interacting with their cell surface substrate site ( the accompanying papers of this series ) . | NA | {
"id": "C0024746",
"name": "mannosidase",
"pos": [
41,
52
]
} | {
"id": "C0017976",
"name": "glycosidase",
"pos": [
151,
162
]
} |
microtubule proteins and tubulin have been purified from brain and labeled with dichlorotriazinyl fluorescein ( dtaf ) . | NA | {
"id": "C0026042",
"name": "microtubule proteins",
"pos": [
0,
20
]
} | {
"id": "C0041348",
"name": "tubulin",
"pos": [
25,
32
]
} |
within 15 min after microinjection of either dtaf-microtubule proteins or dtaf-tubulin into cultured gerbil fibroma cells , there was an evolution of a fluorescent fibrillar pattern with a distribution similar to that of the microtubular network seen after staining with fluorescent antitubulin . | NA | {
"id": "C0026042",
"name": "microtubule proteins",
"pos": [
50,
70
]
} | {
"id": "C0041348",
"name": "tubulin",
"pos": [
287,
294
]
} |
translation of f and mb rna fractions in a messenger-dependent reticulocyte lysate indicates that essentially all mb rna contains poly ( a ) , whereas 25 % of f mrna lacks poly ( a ) . | NA | {
"id": "C0035696",
"name": "rna",
"pos": [
24,
27
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
162,
165
]
} |
transformed fibroblasts , which included rna and dna tumor virus-transformed cells and carcinogen-transformed cells , grew in milk . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
12,
23
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
110,
115
]
} |
the failure of cells to adhere to the substratum in milk-supplemented medium suggested that milk might be deficient in attachment factors for fibroblasts . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
142,
153
]
} |
when the attachment of fibroblastic cells in milk-supplemented medium was facilitated by pretreating culture dishes with fibronectin , ( a ) transformed cells grew attached rather than in suspension , ( b ) normal cell lines attached and grew to confluence , and ( c ) normal cell strains adhered and survived but did not exhibit appreciable cell proliferation . | NA | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
23,
35
]
} | {
"id": "C0007634",
"name": "normal cell",
"pos": [
269,
280
]
} |
these polypeptides have apparent molecular weights of 46,000 and 56,000 daltons and are rich in glutamic acid-glutamine , glycine , and serine . | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
96,
109
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
110,
119
]
} |
this activation , attributable to structure-linked latency , is markedly diminished in dmd cells which show an optimal activation of only 180 % compared to 255 % for control fibroblasts ( p less than 0.01 ) . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
91,
96
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
174,
185
]
} |
a dramatic difference is observed in the intracellular distribution of the high mobility group ( hmg ) proteins when chicken embryo fibroblasts are fractionated into nucleus and cytoplasm by either mass enucleation of cytochalasin-b-treated cells or by differential centrifugation of mechanically disrupted cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
132,
143
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
307,
312
]
} |
the current studies demonstrate that this cell line also expresses 5- to 10-fold more low density lipoprotein ( ldl ) receptors per cell than either human fibroblasts or chinese hamster ovary ( cho ) cells . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
42,
46
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
155,
166
]
} |
the ldl receptors in a-431 cells showed the same affinity and specificity as the ldl receptors in human fibroblasts and other cell types . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
27,
32
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
104,
115
]
} |
the potentiation of adenine toxicity to chinese hamster cells by coformycin : suppression in mutants with altered regulation of purine biosynthesis or increased adenylate-deaminase activity . | NA | {
"id": "C0001407",
"name": "adenine",
"pos": [
20,
27
]
} | {
"id": "C0034140",
"name": "purine",
"pos": [
128,
134
]
} |
in contrast , deinduction kinetics for mt synthesis following removal of the two inducers ( zinc and dex ) are the same , with a half-life of two and one-half hours . | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
26,
34
]
} | {
"id": "C0018517",
"name": "half-life",
"pos": [
129,
138
]
} |
since the plasma dopac concentration appears to reflect central nervous system dopaminergic neuronal activity , the present demonstration of a circadian rhythm of plasma dopac suggests that the activity of central nervous system da-containing cells is higher during the day than at night . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
79,
91
]
} | {
"id": "C0013030",
"name": "da",
"pos": [
270,
272
]
} |
however , the consistently higher values observed when the sm peptide content was measured by rra compared to that measured by ria and the variability in the rra to ria ratio among individual subjects suggest that the igf-i/sm-c ria measures only one of a number of gh-dependent sm peptides . | NA | {
"id": "C0037657",
"name": "sm",
"pos": [
59,
61
]
} | {
"id": "C0021665",
"name": "sm-c",
"pos": [
224,
228
]
} |
however , the consistently higher values observed when the sm peptide content was measured by rra compared to that measured by ria and the variability in the rra to ria ratio among individual subjects suggest that the igf-i/sm-c ria measures only one of a number of gh-dependent sm peptides . | NA | {
"id": "C0037657",
"name": "sm",
"pos": [
59,
61
]
} | {
"id": "C0021666",
"name": "a",
"pos": [
254,
255
]
} |
we have previously demonstrated that somatomedin ( sm ) can induce the loss of specific smc receptors on cultured im-9 lymphocytes in a time- and concentration-dependent manner . | NA | {
"id": "C0037657",
"name": "somatomedin",
"pos": [
37,
48
]
} | {
"id": "C0021665",
"name": "smc",
"pos": [
88,
91
]
} |
overall , a significant inverse correlation was observed between plasma sm levels and mononuclear cellular binding of [ 125i ] smc ( p less than 0.001 ) . | NA | {
"id": "C0037657",
"name": "sm",
"pos": [
68,
70
]
} | {
"id": "C0021665",
"name": "smc",
"pos": [
127,
130
]
} |
the data demonstrate that treatment of hypopituitary dwarfs with conventional therapeutic doses of human gh results in significant acute increases in plasma sm levels in the majority of subjects , with a reciprocal decline in the specific binding of [ 125i ] smc . | NA | {
"id": "C0037657",
"name": "sm",
"pos": [
153,
155
]
} | {
"id": "C0021665",
"name": "smc",
"pos": [
259,
262
]
} |
in the patient with virilism , the tumor 's major secretory product was testosterone ( t ) , and the dominant biosynthetic pathway was pregnenolone ( pe ) leads to 17-hydroxypregnenolone leads to 17-hydroxyprogesterone leads to androstenedione ( delta ) leads to t . | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
135,
147
]
} | {
"id": "C0376260",
"name": "17-hydroxypregnenolone",
"pos": [
164,
186
]
} |
in the patient with estrogenic signs , the major secretory product was delta , derived from a similar pathway of pregnenolone leads to 17-hydroxypregnenolone leads to 17-hydroxyprogesterone leads to delta . | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
113,
125
]
} | {
"id": "C0376260",
"name": "17-hydroxypregnenolone",
"pos": [
135,
157
]
} |
the failure of 1 week of dopaminergic blockade to significantly alter the hormonal ( prl , gh , and cortisol ) responses to itt in the group as a whole suggests that dopamine-blocking mechanisms play little role in mediating these responses , at least in schizophrenic patients . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
25,
37
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
166,
174
]
} |
of 33 freshly dressed turkey carcases , 94 % were positive before chilling in tanks of chlorinated ice and water ; | NA | {
"id": "C0020746",
"name": "ice",
"pos": [
99,
102
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
107,
112
]
} |
0.4 u insulin/kg body wt was infused intravenously over 30 min while blood glucose was maintained constant by glucose infusion . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
69,
82
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
110,
117
]
} |
in addition to anti-rana , we measured antibodies to viral capsid antigen ( anti-vca ) , early antigen ( anti-ea ) and ebv-associated nuclear antigen ( anti-ebna ) . | NA | {
"id": "C0069115",
"name": "anti-rana",
"pos": [
15,
24
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
142,
149
]
} |
in addition to anti-rana , we measured antibodies to viral capsid antigen ( anti-vca ) , early antigen ( anti-ea ) and ebv-associated nuclear antigen ( anti-ebna ) . | NA | {
"id": "C0069115",
"name": "anti-rana",
"pos": [
15,
24
]
} | {
"id": "C0116397",
"name": "ebv",
"pos": [
119,
122
]
} |
since we have shown in previous studies that 6-n-propyl-2-thiouracil ( ptu ) can substitute for gsh as a substrate for the gsh s-transferases , we examined the possibility that ptu might also protect against acetaminophen hepatotoxicity by direct chemical interaction with the reactive metabolite of acetaminophen . | NA | {
"id": "C0033511",
"name": "6",
"pos": [
45,
46
]
} | {
"id": "C0039957",
"name": "ptu",
"pos": [
177,
180
]
} |
of the purine nucleosides known to accumulate in nucleoside phosphorylase-deficient patients , inosine alone caused the phosphate-dependent , irreversible inactivation of purified human placental adohcyase , and of adohcyase in intact erythrocytes and cultured lymphoblastoid cells . | NA | {
"id": "C0034136",
"name": "purine",
"pos": [
7,
13
]
} | {
"id": "C0021528",
"name": "inosine",
"pos": [
95,
102
]
} |
first fibrinopeptide a and fibrin i are formed and then fibrinopeptide b ( b beta 1-14 ) and fibrin ii . | NA | {
"id": "C0016022",
"name": "fibrinopeptide a",
"pos": [
6,
22
]
} | {
"id": "C0015982",
"name": "fibrin",
"pos": [
93,
99
]
} |
first fibrinopeptide a and fibrin i are formed and then fibrinopeptide b ( b beta 1-14 ) and fibrin ii . | NA | {
"id": "C0016023",
"name": "fibrinopeptide b",
"pos": [
56,
72
]
} | {
"id": "C0015982",
"name": "fibrin",
"pos": [
93,
99
]
} |
since it is postulated that fibrin ii is important in the genesis of thrombosis , it is of interest to measure fibrinopeptide b in peripheral blood samples . | NA | {
"id": "C0015982",
"name": "fibrin",
"pos": [
28,
34
]
} | {
"id": "C0016023",
"name": "fibrinopeptide b",
"pos": [
111,
127
]
} |
on the basis of these data it is suggested that plasma desarginine fibrinopeptide b levels reflect fibrin ii formation in vivo . | NA | {
"id": "C0016023",
"name": "fibrinopeptide b",
"pos": [
67,
83
]
} | {
"id": "C0015982",
"name": "fibrin",
"pos": [
99,
105
]
} |
the major protein in the kscn eluate is a single polypeptide chain with an apparent molecular weight of 26,000 in sodium dodecyl sulfate and an amino acid composition essentially identical to that of apoprotein ai , the major protein of rabbit hdl . | NA | {
"id": "C0003601",
"name": "apoprotein",
"pos": [
200,
210
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
226,
233
]
} |
the deletion removes the linked epsilon , gamma- , and delta-globin structural genes and terminates within the coding portion of the beta-globin gene . | NA | {
"id": "C0011244",
"name": "delta-globin",
"pos": [
55,
67
]
} | {
"id": "C0005221",
"name": "beta-globin",
"pos": [
133,
144
]
} |
the hypophosphatemic male mouse , an animal model for human vitamin d-resistant rickets , is characterized by low serum phosphorus concentration due to increased urinary phosphate excretion , rickets , osteomalacia , and dwarfism . | NA | {
"id": "C0035579",
"name": "rickets",
"pos": [
80,
87
]
} | {
"id": "C0029442",
"name": "osteomalacia",
"pos": [
202,
214
]
} |
because phosphate administration can heal rickets but not osteomalacia in the human disease , we have compared the effect of phosphate supplementation on the epiphyseal and endosteal bone mineralization in the mutant animal . | NA | {
"id": "C0035579",
"name": "rickets",
"pos": [
42,
49
]
} | {
"id": "C0029442",
"name": "osteomalacia",
"pos": [
58,
70
]
} |
the increase in uptake of lactate , alanine , and other amino acids was due to a 35-80 % rise in splanchnic fractional extraction plus a 20 % rise in estimated hepatic blood flow . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
36,
43
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
56,
67
]
} |
the fluorescent staining was mediated by a platelet fc receptor , as shown by the absence of platelet staining with immune complex containing antibody preincubated with staphylococcal protein a to block the fc region . | NA | {
"id": "C0003313",
"name": "immune complex",
"pos": [
116,
130
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
142,
150
]
} |
marked increases in epinephrine and slight increases in norepinephrine were associated with increases in plasma glucose and renin activity and decreases in plasma potassium . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
20,
31
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
56,
70
]
} |
acute caffeine in subjects who do not normally ingest methylxanthines leads to increases in blood pressure , heart rate , plasma epinephrine , plasma norepinephrine , plasma renin activity , and urinary catecholamines . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
129,
140
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
150,
164
]
} |
( g ) fivefold increase in circulating cathepsin d titer ( p < 0.005 ) and ( h ) increase in blood norepinephrine ( p < 0.005 ) , dopamine ( p < 0.005 ) , and epinephrine ( p < 0.001 ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
99,
113
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
159,
170
]
} |
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