text
stringlengths 57
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| relation
stringclasses 125
values | h
dict | t
dict |
|---|---|---|---|
the effects of a mixture of red pepper suspension and alpha-alanine ( an amino-acid ) on gastric acid secretion in 33 duodenal ulcer and 18 non-duodenal ulcer patients were studied . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
60,
67
]
} | {
"id": "C0002520",
"name": "amino-acid",
"pos": [
73,
83
]
} |
the fact that it is nearly impossible on many occasions to make a conclusive diagnosis on clinical grounds alone of either endomyocardial fibrosis and heart muscle disease is discussed and the need for haemodynamic and angiographic studies to make the differentiation is stressed . | NA | {
"id": "C0553980",
"name": "endomyocardial fibrosis",
"pos": [
123,
146
]
} | {
"id": "C0878544",
"name": "heart muscle disease",
"pos": [
151,
171
]
} |
40 and 41 of the 358 sera tested were positive for yellow fever and ugmp 359 cf antibodies respectively , with 12 possession cf antibodies to both viruses . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
80,
90
]
} | {
"id": "C0003253",
"name": "antibodies",
"pos": [
128,
138
]
} |
concordant expression of human hexokinase-1 and inorganic pyrophosphatase was established in somatic cell hybrids between thymidine kinase-deficient chinese hamster cells and human fibroblasts carrying a translocation of the distal third of the long arm of chromosome 10 to chromosome 17 . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
165,
170
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
181,
192
]
} |
mutants of class 1 and class 2 which affect proteins pi and p2 , respectively , direct the synthesis of only early proteins in nonsuppressor cells , indicating that these two proteins are involved in the transition from early to late viral protein synthesis . | NA | {
"id": "C0034861",
"name": "synthesis",
"pos": [
91,
100
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
175,
183
]
} |
aminochromes of adrenaline and noradrenaline show resonance raman scattering at 1480 and 1430 cm ( -1 ) respectively , with ar ( + ) excitation . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
16,
26
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
31,
44
]
} |
complex formation between bismuth ( iii ) chloride and potassium diphenyldiselenophosphate has been studied spectrophotometrically in acetronitrile , dimethylformamide , acetone , methanol , ethanol and dimethylsulphoxide media . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
180,
188
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
191,
198
]
} |
concentrations of cadmium of the order of 0.1 ppm in alloy steels containing large concentrations of chromium and nickel ( ca . 17 and 13 % respectively ) , about 0.1 % of copper and a number of metals at low concentrations , were determined by anodic stripping voltammetry with a hanging mercury-drop electrode in 1m hydrochloric acid . | NA | {
"id": "C0002154",
"name": "alloy",
"pos": [
53,
58
]
} | {
"id": "C0038239",
"name": "steels",
"pos": [
59,
65
]
} |
the detector , the response characteristics of which are controlled by the ionization potential of the ethylamine filler gas and the calcium fluoride window employed , is shown to provide for efficient detection of atomic line emission from carbon , oxygen and chlorine in this wavelength region . | NA | {
"id": "C0017110",
"name": "gas",
"pos": [
121,
124
]
} | {
"id": "C0008209",
"name": "chlorine",
"pos": [
261,
269
]
} |
studies on extraction of thorium by the n-oxides of 5- ( 4-pyridyl ) nonane and trioctylamine from different mineral acid solutions and its separation from rare earth elements and yttrium . | NA | {
"id": "C0025556",
"name": "rare",
"pos": [
156,
160
]
} | {
"id": "C0043432",
"name": "yttrium",
"pos": [
180,
187
]
} |
separation factors for a number of metal ions are reported and a method for the separation of thorium from rare earth elements and yttrium is also suggested . | NA | {
"id": "C0025556",
"name": "rare",
"pos": [
107,
111
]
} | {
"id": "C0043432",
"name": "yttrium",
"pos": [
131,
138
]
} |
trace analysis for chlorinated hydrocarbons in air by quantitative combustion and coulometric chloride determination : application to standardization of vinyl chloride permeation tubes . | NA | {
"id": "C0020247",
"name": "chlorinated hydrocarbons",
"pos": [
19,
43
]
} | {
"id": "C0042684",
"name": "vinyl",
"pos": [
153,
158
]
} |
a method is presented for the determination of niobium , tantalum and tungsten in steel and non-ferrous alloys , based on hydrolysis with sulphurous acid followed by x-ray fluorescence measurements . | NA | {
"id": "C0038239",
"name": "steel",
"pos": [
82,
87
]
} | {
"id": "C0002154",
"name": "alloys",
"pos": [
104,
110
]
} |
thorium is eluted with 8m hydrochloric acid and separated from co-eluted substances by anion-exchange in 8m nitric acid medium on a separate 2-g column of the same resin in the nitrate form . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
87,
92
]
} | {
"id": "C0028125",
"name": "nitrate",
"pos": [
177,
184
]
} |
the slopes of the isotherms of various cations are widely different suggesting that separation of these ions on a pyridinium tungstoarsenate column is feasible . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
39,
46
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
104,
108
]
} |
sulphide , sulphite and thiosulphate can be determined separately or in admixture , with thallic perchlorate or sulphate in acid medium . | NA | {
"id": "C0039950",
"name": "thiosulphate",
"pos": [
24,
36
]
} | {
"id": "C0038720",
"name": "sulphate",
"pos": [
112,
120
]
} |
based on this , a method has been developed for accurate determination of small amounts of certain rare earths and yttrium . | NA | {
"id": "C0025556",
"name": "rare earths",
"pos": [
99,
110
]
} | {
"id": "C0043432",
"name": "yttrium",
"pos": [
115,
122
]
} |
coloured products with absorption maxima at 430 , 385 , 430 , 380 and 380 nm , linearly proportional to the concentration of oestrone , oestradiol , ethinyloestradiol , adrenaline and noradrenaline , respectively , are obtained . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
169,
179
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
184,
197
]
} |
organic acid solutions in the chromatography of inorganic ions-iv : cation-exchange of mn ( ii ) , cd ( ii ) , co ( ii ) , ni ( ii ) , cu ( ii ) , al ( iii ) and fe ( iii ) in tartrate media . | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
18,
22
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
68,
74
]
} |
sample is carried in a gas at a flow-rate of 350 ml min . carbon disulphide , methyl mercaptan or sulphur dioxide in amounts up to a hundred times that of the hydrogen sulphide do not interfere . | NA | {
"id": "C0017110",
"name": "gas",
"pos": [
23,
26
]
} | {
"id": "C0038777",
"name": "sulphur dioxide",
"pos": [
98,
113
]
} |
the complex [ zn ( par ) ( 2 ) ] ( cdba ) ( 2 ) , where par is the 4- ( 2-pyridylazo ) resorcinol anion and cdba is cetyldimethylbenzylammonium ion , is extracted from a solution buffered at ph 9.7 with carbonate/bicarbonate . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
98,
103
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
175,
178
]
} |
the complex [ zn ( par ) ( 2 ) ] ( cdba ) ( 2 ) , where par is the 4- ( 2-pyridylazo ) resorcinol anion and cdba is cetyldimethylbenzylammonium ion , is extracted from a solution buffered at ph 9.7 with carbonate/bicarbonate . | NA | {
"id": "C0007026",
"name": "carbonate",
"pos": [
203,
212
]
} | {
"id": "C0005367",
"name": "bicarbonate",
"pos": [
213,
224
]
} |
analyses of the hexose moieties of the gm ( 3 ) -gangliosides of the ms group revealed the presence of only glucose and galactose in a 1:1 ratio . | NA | {
"id": "C0019494",
"name": "hexose",
"pos": [
16,
22
]
} | {
"id": "C0016945",
"name": "galactose",
"pos": [
120,
129
]
} |
antisera raised against oxytocin , [ 8-arginine ] -vasopressin , porcine neurophysin-i and porcine neurophysin-ii were used to localize the neurohypophysial hormones and neurophysins in the paraventricular nucleus ( pvn ) of the pig using immunoenzyme cytochemical techniques . | NA | {
"id": "C0030095",
"name": "oxytocin",
"pos": [
24,
32
]
} | {
"id": "C0032017",
"name": "neurohypophysial hormones",
"pos": [
140,
165
]
} |
drinking to the renin substrate infusions was inhibited by intracranial infusions of either angiotensin i-converting enzyme inhibitor ( sq 20881 ) or a specific aii antagonist , saralasin , indicating that conversion of the substrates to aii was a necessary step in order to produce the drinking responses . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
178,
187
]
} | {
"id": "C0003009",
"name": "aii",
"pos": [
238,
241
]
} |
the volume averaged cross sections for extinction , scattering , absorption , and radiation pressure along with the elements of the phase matrix were computed for a spherical polydispersion of water coated carbon particles . | NA | {
"id": "C0013879",
"name": "elements",
"pos": [
116,
124
]
} | {
"id": "C0007009",
"name": "carbon",
"pos": [
206,
212
]
} |
the changes in the solar absorption by nitrogen dioxide and ozone induced by the injection of no ( x ) ( oxides of nitrogen ) in the stratosphere are complementary , even though the nitrogen dioxide absorption is only a small fraction of the ozone absorption for an unperturbed stratosphere . | NA | {
"id": "C0028167",
"name": "oxides of nitrogen",
"pos": [
105,
123
]
} | {
"id": "C0028160",
"name": "nitrogen dioxide",
"pos": [
182,
198
]
} |
inorganic and organic components of the gaseous tropospheric halogens chlorine , bromine , and iodine have been simultaneously measured . | NA | {
"id": "C0018544",
"name": "halogens",
"pos": [
61,
69
]
} | {
"id": "C0006223",
"name": "bromine",
"pos": [
81,
88
]
} |
similar analyses of sediment deposited during the last ice age ( 18,000 years before the present ) indicate a maximum shallowing of the upper limit of antarctic bottom water ( aabw ) of about 100 meters , coupled with an increase in velocity , which resulted in an increase in aabw transport . | NA | {
"id": "C0020746",
"name": "ice",
"pos": [
55,
58
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
168,
173
]
} |
while e. americanum has a minor effect on energy flow , it may reduce losses of potassium and nitrogen from the ecosystem during the period of maximum removal by incorporating these elements in accumulating biomass . | NA | {
"id": "C0028158",
"name": "nitrogen",
"pos": [
94,
102
]
} | {
"id": "C0013879",
"name": "elements",
"pos": [
182,
190
]
} |
a mineralogic model , derived from computer mixing studies and laboratory analog preparations , suggests that mars fines could be an intimate mixture of about 80 percent iron-rich clay , about 10 percent magnesium sulfate ( kieserite ? ) , about 5 percent carbonate ( calcite ) , and about 5 percent iron oxides ( hematite , magnetite , maghemite , goethite ? ) . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
170,
174
]
} | {
"id": "C0060240",
"name": "iron oxides",
"pos": [
300,
311
]
} |
the following high-temperature minerals were determined : alpha- and beta-cristobalite , quartz , calcic plagioclase , diopsidic pyroxene , wollastonite , cordierite , graphite , fluorapatite , and fluorite ; | NA | {
"id": "C0026162",
"name": "minerals",
"pos": [
31,
39
]
} | {
"id": "C0037098",
"name": "cristobalite",
"pos": [
74,
86
]
} |
the following high-temperature minerals were determined : alpha- and beta-cristobalite , quartz , calcic plagioclase , diopsidic pyroxene , wollastonite , cordierite , graphite , fluorapatite , and fluorite ; | NA | {
"id": "C0037098",
"name": "cristobalite",
"pos": [
74,
86
]
} | {
"id": "C0034387",
"name": "quartz",
"pos": [
89,
95
]
} |
the existence of a hexagonal ( wurtzite ) form of silicon , similar to that form of diamond ( carbon ) observed in meteorites and in the laboratory , has been identified by x-ray diffraction in reaction-bonded silicon nitride containing unreacted silicon . | NA | {
"id": "C0057717",
"name": "diamond",
"pos": [
84,
91
]
} | {
"id": "C0007009",
"name": "carbon",
"pos": [
94,
100
]
} |
an organism ( thermonospora fusca atcc 27730 ) that is known to degrade cellulose but not lignin was shown to grow on lignocellulose in the presence of [ c ] lignocelluloses without evolution of co ( 2 ) . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
72,
81
]
} | {
"id": "C0023705",
"name": "lignin",
"pos": [
90,
96
]
} |
decomposition of c-labeled lignin to co ( 2 ) by the lignin-decomposing fungi phanerochaete chrysosporium and coriolus versicolor required a growth substrate such as cellulose or glucose . | NA | {
"id": "C0023705",
"name": "lignin",
"pos": [
27,
33
]
} | {
"id": "C0007648",
"name": "cellulose",
"pos": [
166,
175
]
} |
tissues of cytoplasmic male sterile , maintainer , restorer , and restored lines , and sterile plants which reverted to fertility in vicia faba were examined in ultrathin sections . | NA | {
"id": "C0021364",
"name": "male sterile",
"pos": [
23,
35
]
} | {
"id": "C0021359",
"name": "sterile",
"pos": [
87,
94
]
} |
the presence of significant maternal and/or reciprocal components in both f ( 1 ) ( 1974 ) and f ( 1 ) by tester diallels suggests that differences in maternal cytoplasm rather than maternal genotype per se were responsible for much of the variation resulting from these non-direct genetic effects . | NA | {
"id": "C0016330",
"name": "components",
"pos": [
55,
65
]
} | {
"id": "C0016327",
"name": "f",
"pos": [
292,
293
]
} |
the present studies have demonstrated unequivocal malabsorption of both simple and conjugated folates in tropical sprue . | NA | {
"id": "C0024523",
"name": "malabsorption",
"pos": [
50,
63
]
} | {
"id": "C0038054",
"name": "tropical sprue",
"pos": [
105,
119
]
} |
the nucleic acid of hyphi30 is linear , double-stranded dna with a molecular weight of 29.7 x 10 ( 6 ) . | NA | {
"id": "C0028606",
"name": "nucleic acid",
"pos": [
4,
16
]
} | {
"id": "C0012854",
"name": "double-stranded dna",
"pos": [
40,
59
]
} |
over 90 % of the radioactive n ( 6 ) -benzyladenosine recovered from the rna preparations was associated with the rrna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
73,
76
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
114,
118
]
} |
purification of the crude rrna by either mak chromatography or sephadex g-200 gel filtration had no effect on the n ( 6 ) -benzyladenosine content of the rna preparation . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
26,
30
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
154,
157
]
} |
legumin from mature seed was found to contain 1 % neutral sugars ( mannose and glucose ) and 0.1 % amino sugar ( glucosamine ) , whereas vicilin contained 0.3 % neutral sugar ( mannose ) and 0.2 % amino sugar ( glucosamine ) . | NA | {
"id": "C0007004",
"name": "sugar",
"pos": [
58,
63
]
} | {
"id": "C0002531",
"name": "amino sugar",
"pos": [
197,
208
]
} |
the results indicate a rapid accumulation and turnover of radioactivity into pc and pg fatty acids ( oleic acid in pc and oleic and palmitic acids in pg ) . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
87,
98
]
} | {
"id": "C0030235",
"name": "palmitic acids",
"pos": [
132,
146
]
} |
the tissue grown on a medium containing ammonium chloride accumulated considerably greater quantities of the two cytokinins made from the labeled adenine during each incubation period . | NA | {
"id": "C0010815",
"name": "cytokinins",
"pos": [
113,
123
]
} | {
"id": "C0001407",
"name": "adenine",
"pos": [
146,
153
]
} |
a pigment synthesized by neurospora whose absorption spectrum resembles the action spectrum is beta-carotene.a model for the regulation of carotenoid biosynthesis in n. crassa is proposed which describes a mechanism by which beta-carotene could act as a photoregulator . | NA | {
"id": "C0007271",
"name": "carotenoid",
"pos": [
139,
149
]
} | {
"id": "C0053396",
"name": "beta-carotene",
"pos": [
225,
238
]
} |
the results show that germinating castor bean endosperm synthesizes membrane lipids de novo from acetate rather than reutilizing stored lipid components directly . | NA | {
"id": "C0025249",
"name": "membrane lipids",
"pos": [
68,
83
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
136,
141
]
} |
in immature rib segments prepared from morning-glory ( ipomoea tricolor ) flower buds , the major soluble metabolite formed from tracer amounts of l-methionine-u- ( 14 ) c was s-methylmethionine ( smm ) . | NA | {
"id": "C0025646",
"name": "methionine",
"pos": [
149,
159
]
} | {
"id": "C0042889",
"name": "methylmethionine",
"pos": [
178,
194
]
} |
in segments of senescing ribs , ( 14 ) c was progressively lost from smm and appeared in free methionine . | NA | {
"id": "C0042889",
"name": "smm",
"pos": [
69,
72
]
} | {
"id": "C0025646",
"name": "methionine",
"pos": [
94,
104
]
} |
immature segments contained about 4 nmoles of free methionine and about 16 nmoles of smm per 30 segments . | NA | {
"id": "C0025646",
"name": "methionine",
"pos": [
51,
61
]
} | {
"id": "C0042889",
"name": "smm",
"pos": [
85,
88
]
} |
as the segments senesced , the methionine content increased about 10-fold while the smm content remained unchanged ; | NA | {
"id": "C0025646",
"name": "methionine",
"pos": [
31,
41
]
} | {
"id": "C0042889",
"name": "smm",
"pos": [
84,
87
]
} |
tracer experiments with l-methionine-u- ( 14 ) c , l-methionine-methyl- ( 3 ) h , and l-homocysteine thiolactone- ( 35 ) s indicated that smm was capable of acting as a methyl donor , and that in senescent segments the methyl group was utilized for methionine production with homocysteine serving as methyl acceptor . | NA | {
"id": "C0042889",
"name": "smm",
"pos": [
138,
141
]
} | {
"id": "C0025646",
"name": "methionine",
"pos": [
249,
259
]
} |
of the 2 molecules of methionine produced in this reaction , 1 was re-methylated to smm , and the other contributed to the observed rise in the content of free methionine . | NA | {
"id": "C0042889",
"name": "smm",
"pos": [
84,
87
]
} | {
"id": "C0025646",
"name": "methionine",
"pos": [
160,
170
]
} |
internal pools of methionine and smm were prelabeled ( but not significantly expanded ) by overnight incubation on 10 mum l-methionine-u- ( 14 ) c . | NA | {
"id": "C0042889",
"name": "smm",
"pos": [
33,
36
]
} | {
"id": "C0025646",
"name": "methionine",
"pos": [
124,
134
]
} |
the specific radioactivity of carbon atoms 3 plus 4 of extracted smm was about twice that of the free methionine . | NA | {
"id": "C0042889",
"name": "smm",
"pos": [
65,
68
]
} | {
"id": "C0025646",
"name": "methionine",
"pos": [
102,
112
]
} |
after overnight exposure of segments to 9 muml-methionine-u- ( 14 ) c , the specific radioactivity of the ethylene evolved by untreated and wounded tissue was determined and compared to the specific radioactivities of carbon atoms 3 plus 4 of methionine and s-methylmethionine ( smm ) extracted from the segments . | NA | {
"id": "C0025646",
"name": "methionine",
"pos": [
47,
57
]
} | {
"id": "C0042889",
"name": "methylmethionine",
"pos": [
260,
276
]
} |
these results are consistent with the interpretations that wound ethylene is synthesized from carbon atoms 3 plus 4 of either smm or methionine . | NA | {
"id": "C0042889",
"name": "smm",
"pos": [
126,
129
]
} | {
"id": "C0025646",
"name": "methionine",
"pos": [
133,
143
]
} |
separation of the lipid extracts by thin layer chromatography revealed four major fractions : wax esters , triacylglycerols , free fatty acids , and phospholipids . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
18,
23
]
} | {
"id": "C0043076",
"name": "wax",
"pos": [
94,
97
]
} |
examination of the 1-butanol-soluble glucolipids from pea ( pisum sativum ) seedlings also demonstrated anionic glucolipids , evidencing metabolic turnover but none with the properties of glucosylated prenol phosphate . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
104,
111
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
208,
217
]
} |
if dna solutions are supplied to axillary buds of vegetative plants and if the axillary buds are defoliated every 4th day for 12 days , the buds supplied a solution of dna from stems in a floral state initiate flowers under noninductive conditions , and the buds supplied a solution of dna from stems in a vegetative state remain vegetative . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
3,
6
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
335,
336
]
} |
the presence of 40 mm succinate decreased acetylene reduction with leguminous proteins supplying 1.4 mg of n/ml but promoted acetylene reduction by rhizobium 32h1-soybean cell associations on media containing alpha-casein , bovine serum albumin , or egg albumin suppling 1.4 mg of n/ml . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
78,
86
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
254,
261
]
} |
sections were cultured for 5,9,13 , or 22 days on a callus medium with zeatin or other cytokinins . | NA | {
"id": "C0043456",
"name": "zeatin",
"pos": [
71,
77
]
} | {
"id": "C0010815",
"name": "cytokinins",
"pos": [
87,
97
]
} |
the escape of tritiated water can be ascribed to diffusion , while the escape of sugars is apparently linked to the metabolism of the surrounding parenchyma cells ( q ( 10 ) sucrose uptake = 3.5 ) . | NA | {
"id": "C0242209",
"name": "sugars",
"pos": [
81,
87
]
} | {
"id": "C0038636",
"name": "sucrose",
"pos": [
174,
181
]
} |
lateral escape rates of sugars from the xylem vessels are in the proportion of sucrose-glucose-fructose ( 2.4:1.0:0.6 ) . | NA | {
"id": "C0242209",
"name": "sugars",
"pos": [
24,
30
]
} | {
"id": "C0038636",
"name": "sucrose",
"pos": [
79,
86
]
} |
the accessibility of xylem parenchyma cells and their differential permeability to sugars control the longitudinal mass transfer of sugars in the xylem vessels.as sucrose and glucose do not compete for uptake from the vessels by the contiguous cells , separate uptake systems for both may be postulated . | NA | {
"id": "C0242209",
"name": "sugars",
"pos": [
83,
89
]
} | {
"id": "C0038636",
"name": "sucrose",
"pos": [
163,
170
]
} |
digestion of the tumor dna preparations with pancreatic deoxyribonuclease i until no detectable dna remained , followed by restoration of solution viscosity by added calf thymus dna , failed to remove the acceleration effect of the tumor dna preparations . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
23,
26
]
} | {
"id": "C0012930",
"name": "tumor dna",
"pos": [
232,
241
]
} |
reisolation of the reannealed nucleic acid formed in this experiment , and digestion with ribonuclease a or deoxyribonuclease i revealed that the double-stranded fraction was composed entirely of dna-dna duplexes , with no detectable dna-rna hybrids . | NA | {
"id": "C0028606",
"name": "nucleic acid",
"pos": [
30,
42
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
234,
237
]
} |
the data indicate that tumor , but not healthy tissue dna preparations contain some factor or factors ( not dna ) which accelerate the reannealing of bacterial dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
54,
57
]
} | {
"id": "C0012924",
"name": "bacterial dna",
"pos": [
150,
163
]
} |
sunflower tumor tissue dnas , therefore , do not contain integrated a. tumefaciens dna sequences in amounts greater than a random ( 1/5 ) of the bacterial genome per diploid amount of plant dna , or a complete bacterial genome per five diploid plant cell dna equivalents . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
23,
26
]
} | {
"id": "C0242964",
"name": "plant dna",
"pos": [
184,
193
]
} |
sunflower tumor tissue dnas , therefore , do not contain integrated a. tumefaciens dna sequences in amounts greater than a random ( 1/5 ) of the bacterial genome per diploid amount of plant dna , or a complete bacterial genome per five diploid plant cell dna equivalents . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
23,
26
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
264,
265
]
} |
however , treatment of a microsomal suspension in 25 % glycerol with 1 % sodium deoxycholate led to the release of about 60 % of the protein and each of the above hemoproteins and electron transfer activities to the fraction which was not pelleted after centrifugation for 2 hours at 105,000g . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
133,
140
]
} | {
"id": "C0018974",
"name": "hemoproteins",
"pos": [
163,
175
]
} |
also , the matrix proteins were soluble in water while the crystalloid proteins were insoluble in water but soluble in salt solution , thus representing albumins and globulins , respectively . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
18,
26
]
} | {
"id": "C0001924",
"name": "albumins",
"pos": [
153,
161
]
} |
also , the matrix proteins were soluble in water while the crystalloid proteins were insoluble in water but soluble in salt solution , thus representing albumins and globulins , respectively . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
18,
26
]
} | {
"id": "C0017649",
"name": "globulins",
"pos": [
166,
175
]
} |
an enzymic electric cell was constructed in which the anode was composed of a zinc plate inserted in aqueous nh ( 4 ) cl solution and the cathode was composed of an electrode made of a glassy carbon stick inserted in a reaction mixture containing cytochrome c ( 3 ) hydrogenase ( h ( 2 ) : ferricytochrome c ( 3 ) oxidoreductase , ec 1.12.2.1 ) and methylviologen under an atmosphere of n ( 2 ) . | NA | {
"id": "C0020284",
"name": "hydrogenase",
"pos": [
266,
277
]
} | {
"id": "C0030016",
"name": "oxidoreductase",
"pos": [
314,
328
]
} |
more probably , the xenon anomalies were established in the early solar system , by mass fractionation during trapping of noble gases in solids and by spontaneous fission of a superheavy element . | NA | {
"id": "C0043339",
"name": "xenon",
"pos": [
20,
25
]
} | {
"id": "C0017112",
"name": "noble gases",
"pos": [
122,
133
]
} |
more probably , the xenon anomalies were established in the early solar system , by mass fractionation during trapping of noble gases in solids and by spontaneous fission of a superheavy element . | NA | {
"id": "C0017112",
"name": "noble gases",
"pos": [
122,
133
]
} | {
"id": "C0013879",
"name": "element",
"pos": [
187,
194
]
} |
two months after removal of the plate and screws , 10 months after the initial trauma , a malignant bone tumour in the form of malignant fibrous histiocytoma was diagnosed at the same location after a renewed fracture . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
79,
85
]
} | {
"id": "C0016658",
"name": "fracture",
"pos": [
209,
217
]
} |
three hours after oral intake of 300 micrograms clonidine in single dose there was significant lowering of the plasma adrenaline and noradrenaline levels . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
118,
128
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
133,
146
]
} |
these results indicate that clonidine decreases plasma adrenaline and noradrenaline levels without significant effect on circulatory regulation . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
55,
65
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
70,
83
]
} |
we conclude that gonadotropin release from the pituitary gland requires the continual presence of gnrh during the ascending limb of the preovulatory gonadotropin surge , and that once the surge has been triggered , the ovaries do not appear to be required for further hypothalamic stimulation . | NA | {
"id": "C0018066",
"name": "gonadotropin",
"pos": [
17,
29
]
} | {
"id": "C0018061",
"name": "gonadotropin",
"pos": [
149,
161
]
} |
the declining progesterone production was not due to the increased conversion of progesterone to the major metabolite , 20 alpha-dihydroprogesterone . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
14,
26
]
} | {
"id": "C0012311",
"name": "20 alpha-dihydroprogesterone",
"pos": [
120,
148
]
} |
the similarities between both the largest and the smallest known forms of the breast tumor estrogen receptor and corresponding forms of other receptors support the notion of the common architecture of steroid receptors in normal and malignant tissues of diverse origins . | NA | {
"id": "C0034804",
"name": "estrogen receptor",
"pos": [
91,
108
]
} | {
"id": "C0034840",
"name": "steroid receptors",
"pos": [
201,
218
]
} |
the inclusion of progesterone , dihydrotestosterone , or 17 beta-estradiol ( but not 20 alpha-dihydroprogesterone ) in the culture together with fsh and agp will overcome the inhibition by agp and restore the induction of lh receptors . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
17,
29
]
} | {
"id": "C0012311",
"name": "20 alpha-dihydroprogesterone",
"pos": [
85,
113
]
} |
the presence of 17-hydroxysteroid oxidoreductase , aromatase , 5 alpha-reductase , and 3-hydroxysteroid oxidoreductase activities in mcf-7 suggests the possibility that the hormonal regulation of these human breast cancer cells may be mediated in part by intracellular estrogen and/or androgen biosynthesis . | NA | {
"id": "C0000165",
"name": "17-hydroxysteroid",
"pos": [
16,
33
]
} | {
"id": "C0020392",
"name": "hydroxysteroid",
"pos": [
89,
103
]
} |
regulation of ovarian cholesterol metabolism : control of 3-hydroxy-3-methylglutaryl coenzyme a reductase and acyl coenzyme a : cholesterol acyltransferase . | NA | {
"id": "C0009226",
"name": "coenzyme a",
"pos": [
85,
95
]
} | {
"id": "C0001374",
"name": "acyl coenzyme a",
"pos": [
110,
125
]
} |
the asynchronous hormonal induction of lactose synthetase components , alpha-lactalbumin and galactosyltransferase , in relation to lactose secretion by mouse mammary explants . | NA | {
"id": "C0022952",
"name": "lactose synthetase",
"pos": [
39,
57
]
} | {
"id": "C0016964",
"name": "galactosyltransferase",
"pos": [
93,
114
]
} |
hormonal induction of the lactose synthetase components , alpha-lactalbumin and galactosyltransferase , in relation to the induced levels of lactose synthetase activity and lactose secretion by mammary gland explants from mature virgin mice was examined . | NA | {
"id": "C0022952",
"name": "lactose synthetase",
"pos": [
26,
44
]
} | {
"id": "C0016964",
"name": "galactosyltransferase",
"pos": [
80,
101
]
} |
on the other hand , galactosyltransferase , lactose synthetase and lactose secretion were only slightly increased at 0.01 microgram/ml , were maximal between 0.1 and 1.0 microgram/ml , and at 10 microgram/ml were still considerably above the baseline levels observed without cortisol . | NA | {
"id": "C0016964",
"name": "galactosyltransferase",
"pos": [
20,
41
]
} | {
"id": "C0022952",
"name": "lactose synthetase",
"pos": [
44,
62
]
} |
with the help of synthetic reference substances , five metabolites of valproic acid ( vpa ) could be quantitated by gas chromatography in the plasma of 26 epileptic patients undergoing chronic therapy with sodium valproate . | NA | {
"id": "C0042291",
"name": "valproic",
"pos": [
70,
78
]
} | {
"id": "C0037567",
"name": "sodium valproate",
"pos": [
206,
222
]
} |
following observations that the intracerebral injection into rats of antiserum to brain gangliosides resulted in recurrent epileptiform activity and that seizure activity was not seen if antibodies were removed by absorption of the antiserum with pure gm1 ganglioside , a study was undertaken to establish characteristics of the immunological agents used to produce this model of epilepsy . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
187,
197
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
232,
241
]
} |
following observations that the intracerebral injection into rats of antiserum to brain gangliosides resulted in recurrent epileptiform activity and that seizure activity was not seen if antibodies were removed by absorption of the antiserum with pure gm1 ganglioside , a study was undertaken to establish characteristics of the immunological agents used to produce this model of epilepsy . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
69,
78
]
} | {
"id": "C1579312",
"name": "immunological agents",
"pos": [
329,
349
]
} |
in fed fish , several amino acids ( alanine , serine , asparagine and glycine ) and lactate produced co2 at considerably higher rates than palmitate . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
22,
33
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
36,
43
]
} |
in fed fish , several amino acids ( alanine , serine , asparagine and glycine ) and lactate produced co2 at considerably higher rates than palmitate . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
22,
33
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
70,
77
]
} |
no evidence could be found to support the contention that alanine is the most important glucogenic amino acid . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
58,
65
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
99,
109
]
} |
with the aid of these methods two main kinds of glycans ( 1a and 2a ) were obtained and fractionated on concanavalin-a -- sepharose into non-reactive ( 1a ) and reactive ( 2a ) molecules . | NA | {
"id": "C0032594",
"name": "glycans",
"pos": [
48,
55
]
} | {
"id": "C0036681",
"name": "sepharose",
"pos": [
122,
131
]
} |
ii ) analysis of nuclear proteins showed that low amounts of basic proteins were present ( basis proteins : dna less than 0.1 ) , the two major one with molecular weights 12 000 and 13 000 and that histones characteristic of eucaryotes were absent . | NA | {
"id": "C0028589",
"name": "nuclear",
"pos": [
17,
24
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
97,
105
]
} |
ii ) analysis of nuclear proteins showed that low amounts of basic proteins were present ( basis proteins : dna less than 0.1 ) , the two major one with molecular weights 12 000 and 13 000 and that histones characteristic of eucaryotes were absent . | NA | {
"id": "C0028589",
"name": "nuclear",
"pos": [
17,
24
]
} | {
"id": "C0019652",
"name": "histones",
"pos": [
198,
206
]
} |
thus , the abilities of epinephrine , norepinephrine , methyldopa , ( +/- ) -methylnorepinephrine and ( +/- ) -methylepinephrine to compete for alpha 1- ( [ 3h ] wb-4101 ) and alpha 2- ( [ 3h ] clonidine ) binding sites in rat brain wee compared . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
24,
35
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
83,
97
]
} |
order of potency at each binding site was : [ 3h ] wb-4101 -- ( - ) epinephrine = ( - ) -norepinephrine greater than ( +/- ) -methylnorepinephrine greater than ( +/- ) -methylepinephrine much greater than ( - ) -methyldopa ; | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
68,
79
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
132,
146
]
} |
[ 3h ] clonidine -- ( - ) -epinephrine greater than ( +/- ) -methylnorepinephrine greater than ( - ) -norepinephrine greater than ( +/- ) -methylepinephrine much greater than ( - ) -methyldopa . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
27,
38
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
102,
116
]
} |
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