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stringlengths 57
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stringclasses 125
values | h
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dict |
|---|---|---|---|
if cells were grown in the absence of whole serum but in the presence of medium containing alpha globulins or fetuin which inhibit both trypsin and cell proteases , such cultures grew as well as cultures containing serum . | NA | {
"id": "C0002211",
"name": "alpha globulins",
"pos": [
91,
106
]
} | {
"id": "C0002210",
"name": "fetuin",
"pos": [
110,
116
]
} |
plasma concentrations of arginine-vasopressin ( antidiuretic hormone ) have been measured in 40 patients with benign essential hypertension and 12 patients with malignant-phase hypertension . | NA | {
"id": "C0003779",
"name": "arginine-vasopressin",
"pos": [
25,
45
]
} | {
"id": "C0042413",
"name": "antidiuretic hormone",
"pos": [
48,
68
]
} |
host resistance against bacterial lipopolysaccharides ( l.p.s . ) and especially against its toxic part lipid a has earlier been demonstrated in biological assays . | NA | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
34,
53
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
104,
111
]
} |
in domestic pigs repeated applications of gastrointestinal hormones ( pancreozymin , secretin ) as well as cholecystectomy lead to histologic transformation of the epithelium in the area of the papilla of vater and to inconstant pressure changes in the common duct . | NA | {
"id": "C0017182",
"name": "gastrointestinal hormones",
"pos": [
42,
67
]
} | {
"id": "C0008328",
"name": "pancreozymin",
"pos": [
70,
82
]
} |
in domestic pigs repeated applications of gastrointestinal hormones ( pancreozymin , secretin ) as well as cholecystectomy lead to histologic transformation of the epithelium in the area of the papilla of vater and to inconstant pressure changes in the common duct . | NA | {
"id": "C0017182",
"name": "gastrointestinal hormones",
"pos": [
42,
67
]
} | {
"id": "C0036534",
"name": "secretin",
"pos": [
85,
93
]
} |
with the use of an organ redoximeter , the effects of noradrenaline , adrenaline , isoproterenol , and phenylephrine on the oxidation-reduction state of the myocardial pyridine nucleotides were studied in the canine heart-lung preparation supported by a donor . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
54,
67
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
70,
80
]
} |
noradrenaline and adrenaline produced an initial , transient improvement , and phenylephrine a sustained improvement , of the redox state , while isoproterenol produced a depression . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
0,
13
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
18,
28
]
} |
pretreatment of the preparation with adrenergic alpha-blockers resulted in an abolishment of the improvement by noradrenaline , adrenaline , and phenylephrine , while the depression by isoproterenol remained unchanged . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
112,
125
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
128,
138
]
} |
whereas noradrenaline and adrenaline produced a sustained improvement after an adrenergic beta-blocker , propranolol , the effect of isoproterenol was abolished . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
8,
21
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
26,
36
]
} |
this tracer study shows the presence of a pool of myocardial fatty acids with a relatively slow turnover rate that may constitute an important reservoir of ffa . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
61,
72
]
} | {
"id": "C0015688",
"name": "ffa",
"pos": [
156,
159
]
} |
increased dietary availability of docosahexaenoic acid ( 22:6 omega3 ) leads to extensive replacement of linoleic acid ( 18:2omega6 ) and arachidonic acid ( 20:4omega6 ) in phospholipids . | NA | {
"id": "C0012968",
"name": "docosahexaenoic acid",
"pos": [
34,
54
]
} | {
"id": "C0015689",
"name": "omega3",
"pos": [
62,
68
]
} |
paralleling the increase in plamsa norepinephrine ( ne ) and epinephrine ( e ) induced by ach infusion , hemodynamic measurements showed a positive inotropic response with increase in pulse , blood pressure , left ventricular contractility , and cardiac output . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
35,
49
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
61,
72
]
} |
to investigate the mechanism by which catecholamines produce myocardial ischemia , the effect of intracoronary-administered adrenaline and noradrenaline was studied in dogs with graded coronary constriction . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
124,
134
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
139,
152
]
} |
effects of beta-adrenergic blocking agent ( propranolol ) on metabolic response to adrenaline and noradrenaline in dogs with coronary constriction . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
83,
93
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
98,
111
]
} |
to obtain further information on the mechanism by which catecholamines produce myocardial ischemia , the effects of propranolol on metabolic and mechanical responses to adrenaline or noradrenaline were investigated in coronary-constricted dogs . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
169,
179
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
183,
196
]
} |
propranolol suppressed the myocardial ischemia produced by noradrenaline and adrenaline in dogs with moderate coronary constriction . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
59,
72
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
77,
87
]
} |
the findings were compared with those obtained in noncoronarogenic myocardial injury models following administration of norepinephrine , a pressor , and isoproterenol , a depressor catecholamine . | NA | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
153,
166
]
} | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
181,
194
]
} |
the concentrations of atp and phosphorylcreatine ( pc ) were decreased in the adriamycin-treated cells , but the addition of creatine resulted in a several-fold increase of pc . | NA | {
"id": "C0010286",
"name": "creatine",
"pos": [
40,
48
]
} | {
"id": "C0031634",
"name": "pc",
"pos": [
173,
175
]
} |
in all three systems induction was carried out with 0.5 mg fentanyl or 0.05 mg sulfentanil , followed by etomidate and a muscle relaxant . | NA | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
59,
67
]
} | {
"id": "C0143993",
"name": "sulfentanil",
"pos": [
79,
90
]
} |
in a second series reinjections were done with 0.5 mg of fentanyl or 0.05 mg of sulfentanil . | NA | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
57,
65
]
} | {
"id": "C0143993",
"name": "sulfentanil",
"pos": [
80,
91
]
} |
the authors present the concept that a multi-disciplinary interdepartmental pain center should include : 1 ) an initial out-patient pain clinic , 2 ) an inpatient pain service for diagnosis of pain problems and treatment of patients with intractable pain , including pain from cancer , 3 ) a psychotherapeutically-oriented chronic benign pain unit , 4 ) facilities for clinical and basic pain research , and 5 ) affiliations for an adequate teaching program . | NA | {
"id": "C0030200",
"name": "intractable pain",
"pos": [
238,
254
]
} | {
"id": "C0030193",
"name": "pain",
"pos": [
388,
392
]
} |
the authors present the concept that a multi-disciplinary interdepartmental pain center should include : 1 ) an initial out-patient pain clinic , 2 ) an inpatient pain service for diagnosis of pain problems and treatment of patients with intractable pain , including pain from cancer , 3 ) a psychotherapeutically-oriented chronic benign pain unit , 4 ) facilities for clinical and basic pain research , and 5 ) affiliations for an adequate teaching program . | NA | {
"id": "C0596240",
"name": "pain",
"pos": [
76,
80
]
} | {
"id": "C0030193",
"name": "pain",
"pos": [
388,
392
]
} |
this depression is caused by a blocking factor that may be present as an antigen , antibody , or antigen-antibody complex . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
83,
91
]
} | {
"id": "C0003313",
"name": "antigen-antibody complex",
"pos": [
97,
121
]
} |
`` `` twenty cases of down 's syndrome and 25 age-matched normal controls were subjected to hematologic study including hb , r.b.cs , w.b.cs. , hbf. , bone marrow , protein electrophoresis and chromosomal study . peripheral blood and bone marrow showed noticeable increase in granulocytes , increase in staff , and decrease in lymphocytes in mongols as compared to the controls . hbf was lower than normal in 18 cases . the other two showed abnormally high hbf . protein electrophoretic study showed normal pattern except one case in which a remarkable decrease in the beta and gamma fraction was noticed '' '' . | NA | {
"id": "C0019046",
"name": "h",
"pos": [
54,
55
]
} | {
"id": "C0015936",
"name": "hb",
"pos": [
120,
122
]
} |
the comparison of citrate-synthase activities , citrate levels in tissues and 14c-incorporation from different precursors into citric acid permitted us to establish that the biosynthesis of citrate in brain was more intensive than in other tissues studied . | NA | {
"id": "C0055819",
"name": "citric",
"pos": [
127,
133
]
} | {
"id": "C0008857",
"name": "citrate",
"pos": [
190,
197
]
} |
nad-specific isocitrate dehydrogenase reaction was found to be the dominant pathway for citrate oxidation in brain : more than 60 percent of brain citrate were oxidized by nad-icdh , while less than 10 percent of citric acid were utilized by this enzyme in other tissues studied . | NA | {
"id": "C0008857",
"name": "citrate",
"pos": [
16,
23
]
} | {
"id": "C0055819",
"name": "citric acid",
"pos": [
213,
224
]
} |
the existance of an adenine nucleotide control of nad-icdh activity in brain may be an additional mechanism for the regulation of the first steps of energy metabolism in brain . | NA | {
"id": "C0001413",
"name": "adenine nucleotide",
"pos": [
20,
38
]
} | {
"id": "C0027270",
"name": "nad",
"pos": [
50,
53
]
} |
in three of these patients , iabp assist was started before the surgical procedure because these patients were in cardiogenic shock due to myocardial infarction . | NA | {
"id": "C0036980",
"name": "cardiogenic shock",
"pos": [
114,
131
]
} | {
"id": "C0027051",
"name": "myocardial",
"pos": [
139,
149
]
} |
serum gamma-glutamyl transpeptidase ( gamma-gt ) level was estimated in 132 patients with different liver diseases ( chronic persistent and chronic active hepatitis , postnecrotic cirrhosis , chronic alcholic hepatitis and alcoholic cirrhosis , cholestasis syndrome , fatty liver , gilbert disease ) and malignancies with and without liver involvement . | NA | {
"id": "C0023895",
"name": "liver diseases",
"pos": [
100,
114
]
} | {
"id": "C0015695",
"name": "fatty liver",
"pos": [
268,
279
]
} |
the primary and secondary structure of the three kinds of gastrointestinal hormones , i.e . gastrin , cholecystokinin-pancreozymin and secretin are discussed . | NA | {
"id": "C0017182",
"name": "gastrointestinal",
"pos": [
58,
74
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
92,
99
]
} |
the primary and secondary structure of the three kinds of gastrointestinal hormones , i.e . gastrin , cholecystokinin-pancreozymin and secretin are discussed . | NA | {
"id": "C0017182",
"name": "gastrointestinal",
"pos": [
58,
74
]
} | {
"id": "C0008328",
"name": "cholecystokinin-pancreozymin",
"pos": [
102,
130
]
} |
the primary and secondary structure of the three kinds of gastrointestinal hormones , i.e . gastrin , cholecystokinin-pancreozymin and secretin are discussed . | NA | {
"id": "C0017182",
"name": "gastrointestinal",
"pos": [
58,
74
]
} | {
"id": "C0036534",
"name": "secretin",
"pos": [
135,
143
]
} |
all derivatives of the c-terminal tetrapeptide fragment of gastrins with 17 amino acids elicit every physiological effect of the gastrin . | NA | {
"id": "C0039659",
"name": "tetrapeptide",
"pos": [
34,
46
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
129,
136
]
} |
the present state of chemistry , structure-activity relationship and cellular mode of action of gastrointestinal polypeptide hormones ( gastrin , secretin , cholecystokinin-pancreozymin , caerulein and bombesin ) are reviewed . | NA | {
"id": "C0017182",
"name": "gastrointestinal",
"pos": [
96,
112
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
136,
143
]
} |
the present state of chemistry , structure-activity relationship and cellular mode of action of gastrointestinal polypeptide hormones ( gastrin , secretin , cholecystokinin-pancreozymin , caerulein and bombesin ) are reviewed . | NA | {
"id": "C0017182",
"name": "gastrointestinal",
"pos": [
96,
112
]
} | {
"id": "C0036534",
"name": "secretin",
"pos": [
146,
154
]
} |
the present state of chemistry , structure-activity relationship and cellular mode of action of gastrointestinal polypeptide hormones ( gastrin , secretin , cholecystokinin-pancreozymin , caerulein and bombesin ) are reviewed . | NA | {
"id": "C0017182",
"name": "gastrointestinal",
"pos": [
96,
112
]
} | {
"id": "C0008328",
"name": "cholecystokinin-pancreozymin",
"pos": [
157,
185
]
} |
results of investigations on the metabolism of gastrin , pentagastrin , cholecystokinin and secretin are discussed on the basis of data in the literature . | NA | {
"id": "C0017151",
"name": "gastrin",
"pos": [
47,
54
]
} | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
57,
69
]
} |
present knowledge about gastrointestinal peptide hormones is discussed from three points of view : ( a ) diagnostic significance of these hormones ; | NA | {
"id": "C0017182",
"name": "gastrointestinal",
"pos": [
24,
40
]
} | {
"id": "C0019932",
"name": "hormones",
"pos": [
138,
146
]
} |
the effects of addition of the essential amino acids , l-lysine and dl-methionine , were compared with those of the nonessential glycine and l-glutamic acid . | NA | {
"id": "C0002525",
"name": "essential amino acids",
"pos": [
31,
52
]
} | {
"id": "C0025646",
"name": "methionine",
"pos": [
71,
81
]
} |
the probable mechanisms of action of the above anions on mg-atpase and possible relation to passive permeability of na+ and k+ ions are discussed . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
47,
53
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
127,
131
]
} |
in a group of 29 patients with mechanical icterus and a control group of 38 patients ( acute , chronic hepatitis and hyperbilirubinemia ) there have been followed up alkaline phosphatase , leucinaminopeptidase and gammaglutamil transpeptidase activities aiming to evaluate the value of gamma gt in differentiation of icterus of various etiology . | NA | {
"id": "C0020433",
"name": "hyperbilirubinemia",
"pos": [
117,
135
]
} | {
"id": "C0022346",
"name": "icterus",
"pos": [
317,
324
]
} |
the disorders mentioned include : eczematous processes , rosacea-like dermatitis , steroid rosacea , acne , especially the diagnosis and therapy of cystic acne , psoriasis , atopic dermatitis , viral infection ( heck 's disease ) and circumscribed scleroderma versus systemic sclerosis and hemiatrophy of the face . | NA | {
"id": "C0011603",
"name": "dermatitis",
"pos": [
70,
80
]
} | {
"id": "C0011615",
"name": "atopic dermatitis",
"pos": [
174,
191
]
} |
in contrast , acquired progressive depigmentation represented by vitiligo vulgaris and sutton 's leukoderma is characterized by the loss of premelanosome synthesis . | NA | {
"id": "C0042900",
"name": "vitiligo",
"pos": [
65,
73
]
} | {
"id": "C0162835",
"name": "leukoderma",
"pos": [
97,
107
]
} |
[ studies on arsenic metabolism ( report 19 ) . the toxicity and detoxication of arsenic trioxide paste on rat mucous membrane ( author 's transl ) ] . | NA | {
"id": "C0003818",
"name": "arsenic",
"pos": [
13,
20
]
} | {
"id": "C0052416",
"name": "arsenic trioxide",
"pos": [
81,
97
]
} |
the highest frequencies of lymphatic spread in the different metastasized tumours were found to be : bone sarcomas : reticulosarcoma 100 % , ewing 's sarcoma 50 % , osteosarcoma 47 % . | NA | {
"id": "C0553580",
"name": "ewing 's sarcoma",
"pos": [
141,
157
]
} | {
"id": "C0029463",
"name": "osteosarcoma",
"pos": [
165,
177
]
} |
there was a concomitant increase in the levels of erythrocyte glutathione reductase ( gssg nadph reductase ) and glutathione peroxidase ( gsh : h2o2 peroxidase ) during deficiency . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
86,
90
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
138,
141
]
} |
in vivo acylation of triglycerides and phosphoglycerides of liver subcellular fractions with palmitate-1-14c in rats fed vitamin a . | NA | {
"id": "C0073115",
"name": "palmitate-1-14c",
"pos": [
93,
108
]
} | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
121,
130
]
} |
incorporation of palmitate-1-14c into liver and its mitochondrial , and microsomal triglycerides and phosphoglycerides of rats fed 100000 i.u . of vitamin a for two days has been studied . | NA | {
"id": "C0073115",
"name": "palmitate-1-14c",
"pos": [
17,
32
]
} | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
147,
156
]
} |
the incorporation of palmitate-1-14c ( counts/min/liver ) into triglycerides of liver mitochondrial , microsomal and supernatant fractions of vitamin a fed rats was significantly higher , whereas in phosphatidyl ethanolamine and phosphatidyl choline it was not significantly different from the controls . | NA | {
"id": "C0073115",
"name": "palmitate-1-14c",
"pos": [
21,
36
]
} | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
142,
151
]
} |
in addition no rise in fasting vitamin e levels was seen after 3 subjects had been loaded for 4 days with 0.5 g dl alpha-tocopherol acetate/day . | NA | {
"id": "C0042874",
"name": "vitamin e",
"pos": [
31,
40
]
} | {
"id": "C0994472",
"name": "dl alpha-tocopherol acetate",
"pos": [
112,
139
]
} |
interest in the 5- , 6- , and 7-trifluoromethyl-substituted 2,3-bis ( 4-methoxyphenyl ) indoles as potent , orally active anti-inflammatory agents required a method for their determination in serum , urine , and feces to permit studies of their absorption , metabolism , and excretion . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
258,
268
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
275,
284
]
} |
effect of nonionic surfactants on percutaneous absorption of salicylic acid and sodium salicylate in the presence of dimethyl sulfoxide . | NA | {
"id": "C0036079",
"name": "salicylic acid",
"pos": [
61,
75
]
} | {
"id": "C0037549",
"name": "sodium salicylate",
"pos": [
80,
97
]
} |
fifteen nonionic surfactants , 10 % ( w/w ) , were each incorporated into white petrolatum usp ointment base containing 10 % ( w/w ) salicylic acid or 11.6 % ( w/w ) sodium salicylate with 10 % ( w/w ) dimethyl sulfoxide . | NA | {
"id": "C0036079",
"name": "salicylic acid",
"pos": [
133,
147
]
} | {
"id": "C0037549",
"name": "sodium salicylate",
"pos": [
166,
183
]
} |
percutaneous absorption of salicylic acid was increased significantly when sorbitan monopalmitate , sorbitan trioleate , poloxamer 231 , poloxamer 182 , polyoxyethylene 4 lauryl ether , polyoxyethylene 2 oleyl ether , or polyoxyl 8 stearate was added to the ointment containing dimethyl sulfoxide , salicylic acid , and white petrolatum . | NA | {
"id": "C0600615",
"name": "poloxamer",
"pos": [
121,
130
]
} | {
"id": "C1572787",
"name": "poloxamer 182",
"pos": [
137,
150
]
} |
a method for the simultaneous determination of cyanocobalamin , cobinamide ( factor b ) , and hydroxocobalamin in the solid state is described . | NA | {
"id": "C0042845",
"name": "cyanocobalamin",
"pos": [
47,
61
]
} | {
"id": "C0020316",
"name": "hydroxocobalamin",
"pos": [
94,
110
]
} |
recently , the sanorex preparation ( mazindol , teronak , an 448 degrees -- imidazo-isoindole derivative having a tricyclic structure ) is ever more extensively used . | NA | {
"id": "C0024977",
"name": "mazindol",
"pos": [
37,
45
]
} | {
"id": "C1956073",
"name": "isoindole",
"pos": [
84,
93
]
} |
etiology and pathogenesis of empty cella syndrome remains undetermined in some cases ( primary or idiopathic type ) , while in others it is related to treatment of pituitary and parasellar disease ( secondary type ) . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
41,
49
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
189,
196
]
} |
while as low as 10 m delta-tetrahydrocannabinol showed appreciable decrements in both the membrane-bound atpases , the other cannabinoids did not show such a great depression in enzyme activity . | NA | {
"id": "C0039663",
"name": "tetrahydrocannabinol",
"pos": [
27,
47
]
} | {
"id": "C0006864",
"name": "cannabinoids",
"pos": [
125,
137
]
} |
it was additionally shown that the cannabinoids , delta-tetrahydrocannabinol in particular , bound to the synaptic membranes almost irreversibly in the in vitro system , and that the vehicle for dissolving the cannabinoids , while used as background control values when calculating the percentage decrements in enzyme specific activity , did vary the effects on the atpase enzymes in particular . | NA | {
"id": "C0039663",
"name": "tetrahydrocannabinol",
"pos": [
56,
76
]
} | {
"id": "C0006864",
"name": "cannabinoids",
"pos": [
210,
222
]
} |
increasing oestrogen output during the follicular phase was associated with decreasing levels of osmolality , urea , total protein and the albumin free protein fraction . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
139,
146
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
152,
159
]
} |
bovine albumin , human albumin and human epidermis protein were used as carrier proteins in the complexes . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
7,
14
]
} | {
"id": "C0304925",
"name": "human",
"pos": [
35,
40
]
} |
this paper describes the assay system for two different types of lymphocyte complement receptors , the immune adherence receptor ( c3b receptor ) and the c3d receptor . | NA | {
"id": "C0034793",
"name": "complement receptors",
"pos": [
76,
96
]
} | {
"id": "C0034817",
"name": "immune",
"pos": [
103,
109
]
} |
the pathologic process is induced principally by anticoagulant therapy , bleeding diathesis , or abdominal trauma and occurs as a localized , well-defined , intramural mass or as a more diffuse segmental involvement . | NA | {
"id": "C0030660",
"name": "pathologic process",
"pos": [
4,
22
]
} | {
"id": "C0019080",
"name": "bleeding",
"pos": [
73,
81
]
} |
corticosterone ( b ) and a less polar form or derivative of 18-hydroxycorticosterone obtained by dissolving the mother-steroid in 0.01 n hcl , ( l ) , were assayed as precursors to aldosterone in : 1 ) samples only containing buffer ( c ) ; | NA | {
"id": "C0010124",
"name": "corticosterone",
"pos": [
0,
14
]
} | {
"id": "C0000172",
"name": "18-hydroxycorticosterone",
"pos": [
60,
84
]
} |
the effect of different porphyrins , porphyrinogens and haemin on uroprophyrinogen decarboxylation was also studied to see the influence of nature and position of the side chains of pyrroles as well as the oxidation state in the tetrapyrrolic ring . | NA | {
"id": "C0032712",
"name": "porphyrins",
"pos": [
24,
34
]
} | {
"id": "C0032711",
"name": "porphyrinogens",
"pos": [
37,
51
]
} |
correlatively , an increase in the levels of adenosine 5'-monophosphate ( amp ) and guanosine 5'-monophosphate ( gmp ) and adenosine 5'-pyrophosphate ( adp ) and guanosine 5'-pyrophosphate ( gdp was observed . | NA | {
"id": "C0001413",
"name": "adenosine",
"pos": [
45,
54
]
} | {
"id": "C0001459",
"name": "adenosine",
"pos": [
123,
132
]
} |
epileptic paroxystic headache consists of an episode of pain that starts suddenly , in a varying area that is usually the same for the same patient , of medium to high intensity , lasting from a few seconds to minutes and , rarely , hours ; | NA | {
"id": "C0018681",
"name": "headache",
"pos": [
21,
29
]
} | {
"id": "C0030193",
"name": "pain",
"pos": [
56,
60
]
} |
the metabolism of synacthen ( corticotrophin- ( 1 -- 24 ) -tetracosapeptide ) and c-41795-ba ( [ d-ser1 , lys17 , lys18 ] -corticotrophin- ( 1 -- 18 ) -octadecapeptide amide ) have been compared in the rat following intravenous injection . | NA | {
"id": "C0010192",
"name": "tetracosapeptide",
"pos": [
59,
75
]
} | {
"id": "C0001655",
"name": "corticotrophin",
"pos": [
123,
137
]
} |
comparisons of synthetic 1-18 acth ( organon 2001 ) and 1-39 acth of animal origin in human subjects . | NA | {
"id": "C0010192",
"name": "synthetic",
"pos": [
15,
24
]
} | {
"id": "C0001655",
"name": "1-39 acth",
"pos": [
56,
65
]
} |
nas of aromatic amino acids ( phe , tyr , trp ) are hydrolyzed predominantly by an enzyme showing maximum activity in uterine epithelium and in walls of blood vessels . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
7,
27
]
} | {
"id": "C0031453",
"name": "phe",
"pos": [
30,
33
]
} |
when nas of basic ( arg , lys ) or certain other ( gly , ala ) amino acids were used , a strong reaction was obtained in myometrium , uterine epithelium , blood vessels and trophoblast as well . | NA | {
"id": "C0017890",
"name": "gly",
"pos": [
51,
54
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
63,
74
]
} |
by means of thin layer chromatography and selective detection , vitamin a acetate , vitamin e and vitamin e acetate , vitamin d3 and cholesterol were identified in the prepericardic body , adrenal tissue , fat bodies and testis of bubo bufo , as well as in the prepericardic body of rana esculenta . | NA | {
"id": "C0042874",
"name": "vitamin e",
"pos": [
84,
93
]
} | {
"id": "C0078373",
"name": "vitamin e acetate",
"pos": [
98,
115
]
} |
the ribosomal rna transport from a nucleus to a perinuclear cytoplasm and its following distribution in the cytoplasm of acetabularia mediterranea cells were studied using transplantation of rna-labeled rhizoid into unlabeled stalk . | NA | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
4,
17
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
191,
194
]
} |
to clarify the influence of protein surrounding on the heme reactivity in heme proteins the effect of interaction between a porphyrin ring and pi-acceptor molecule , 1,2,4-trimethyl-pyridinium ( tmp ) , on the affinity of deuteroheme to axial ligands ( imidazole and cyanide ) has been studied as a model system . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
28,
35
]
} | {
"id": "C0018974",
"name": "heme",
"pos": [
229,
233
]
} |
the comparison of the equilibrium constant values allowed to find the sequence of probabilities of the approach of aromatic amino acids to adenosine-5'-phosphate ( tryptophan greater than tyrosine greater than phenylalanine ) . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
115,
135
]
} | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
164,
174
]
} |
the comparison of the equilibrium constant values allowed to find the sequence of probabilities of the approach of aromatic amino acids to adenosine-5'-phosphate ( tryptophan greater than tyrosine greater than phenylalanine ) . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
115,
135
]
} | {
"id": "C0041485",
"name": "tyrosine",
"pos": [
188,
196
]
} |
the comparison of the equilibrium constant values allowed to find the sequence of probabilities of the approach of aromatic amino acids to adenosine-5'-phosphate ( tryptophan greater than tyrosine greater than phenylalanine ) . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
115,
135
]
} | {
"id": "C0031453",
"name": "phenylalanine",
"pos": [
210,
223
]
} |
a comparative x-ray study of dna compact particles , formed in peg-containing solution from native dna and from dna molecules with altered secondary structure was carried out . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna molecules",
"pos": [
112,
125
]
} |
[ nucleoprotein melting . i. theory of helix-coil transition of dna in the presence of proteins with cooperative character of interaction under conditions of reversible binding ] . | NA | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
2,
15
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
87,
95
]
} |
3 ) the changing of the form of the divertion system is considered immediately after an abdominal aseptic intolerance is present ( ileus , ascites , etc . ) , due to the double risk of intestinal occlusion or ventriculitis . | NA | {
"id": "C1258215",
"name": "ileus",
"pos": [
131,
136
]
} | {
"id": "C0021843",
"name": "intestinal occlusion",
"pos": [
185,
205
]
} |
etiological factors are analyzed dividing the patients in two groups according to the age of beginning of seizures ( before or after 25 years ) and in the younger groups perinatal factors and epilepsy of unknown origin predominate , while in the older group vascular and tumoral causes are more frequent . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
106,
114
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
192,
200
]
} |
compared to cortisol these sex hormones are relatively weak suppressors of lymphocyte blastogenesis ( cortisol 10 ( -7 ) m , progesterone 5 times 10 ( -6 ) m , testosterone 5 times 10 ( -5 ) m , diethylstilbestrol 5 times 10 ( -5 ) m and diethylstilbestrol diphosphate 10 ( -3 ) m ) and probably are not significantly immunosuppressive in commonly used pharmacologic dosages . | NA | {
"id": "C0012203",
"name": "diethylstilbestrol",
"pos": [
195,
213
]
} | {
"id": "C0060692",
"name": "10",
"pos": [
269,
271
]
} |
the re-evaluation of the diuretic agent at this point will usually necessitate the substitution of furosemide for thiazide or the doubling of the dose of the present loop diuretic . | NA | {
"id": "C0012798",
"name": "diuretic",
"pos": [
25,
33
]
} | {
"id": "C0354100",
"name": "loop diuretic",
"pos": [
166,
179
]
} |
this paper reviews the clinical and pathological differences of the systemic vasculitides , and a working approach to the differential diagnosis of vasculitis is formulated based on the size of the vessel involved . | NA | {
"id": "C0264939",
"name": "systemic vasculitides",
"pos": [
68,
89
]
} | {
"id": "C0042384",
"name": "vasculitis",
"pos": [
148,
158
]
} |
however , when cultured skin fibroblasts from cystinotic patients and normal control individuals are incubated in se-d , l-methionine , se-d , l-cystine , se-cystamine x hcl , se-urea , selenite or in medium without added selenium , only the cystinotic fibroblasts grown in se-urea or selenite ( seo3= ) contain more selenium than do the corresponding normal cells ( p less than 0.05 ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
29,
40
]
} | {
"id": "C0007634",
"name": "normal cells",
"pos": [
352,
364
]
} |
the addition of subtoxic concentrations of zinc ( 200 ppm in form of zncl2 ) to supply water containing 5 ppm of se abolishes the cancer-protecting effect of selenium . | NA | {
"id": "C0043481",
"name": "zinc",
"pos": [
43,
47
]
} | {
"id": "C0078774",
"name": "zncl2",
"pos": [
69,
74
]
} |
the interaction of metal cations with single chain globular proteins produces volume increases , the magnitude of which is determined primarily by the ion and to a lesser extent by the protein . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
25,
32
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
151,
154
]
} |
evaluation of the pulmonary venous pressure is of great importance , however , in differentiating pulmonary vascular disease from pulmonary hypertension secondary to patch obstruction of pulmonary venous return . | NA | {
"id": "C0042373",
"name": "vascular disease",
"pos": [
108,
124
]
} | {
"id": "C0020538",
"name": "hypertension",
"pos": [
140,
152
]
} |
the serum was ultracentrifugally fractionated into six classes of lipoproteins and analyzed for lipid composition and protein content . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
66,
78
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
96,
101
]
} |
disc gel electrophoresis using lipid and protein stains established that the various lipoprotein subclasses were reasonably free of adjacent density fractions . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
31,
36
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
85,
96
]
} |
precise agreement was found between the distribution of lipid reacting with oil red 0 and specific fluorescence for tldl in endothelial cells , in extracellular deposits in the intimal ground-substance and in medial smooth muscle cells . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
56,
61
]
} | {
"id": "C0028908",
"name": "oil",
"pos": [
76,
79
]
} |
it is suggested that these results establish that rabbit tldl serve as the vehicles transporting lipid into the experimental lesions , just as the homologous human lipoproteins do in human atherosclerosis . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
97,
102
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
164,
176
]
} |
( 3 ) with semisynthetic diets in the whole cholesterol range 250-400 mg/100 ml it was possible , with respect to cholesterol , to induce fairly similar concentrations and distributions to those seen in man , with about 60 % transported as `` '' ldl '' '' , 30 % as `` '' vldl '' '' and 10 % as `` '' hdl '' '' cholesterol with the coconut oil diet and 65 % , 20 % and 15 % , respectively , with the butter diet . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
44,
55
]
} | {
"id": "C0023822",
"name": "as",
"pos": [
84,
86
]
} |
( 4 ) compared with earlier investigations on rabbits , the present distribution study suggests that the degree of aortic lipid infiltration in cholesterol-fed rabbits is better related to the levels of `` '' ldl '' '' than to `` '' vldl '' '' cholesterol . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
144,
155
]
} | {
"id": "C0023826",
"name": "`` '' v",
"pos": [
227,
234
]
} |
under pathological conditions ( inflammations , impediment of secretion fluid , radiation effects etc . ) metaplasias and proliferations of the duct system arise with development of indifferent duct formations analogous to the type of an embryonal salivary gland . | NA | {
"id": "C0030660",
"name": "pathological conditions",
"pos": [
6,
29
]
} | {
"id": "C0021368",
"name": "inflammations",
"pos": [
32,
45
]
} |
under pathological conditions ( inflammations , impediment of secretion fluid , radiation effects etc . ) metaplasias and proliferations of the duct system arise with development of indifferent duct formations analogous to the type of an embryonal salivary gland . | NA | {
"id": "C0030660",
"name": "pathological conditions",
"pos": [
6,
29
]
} | {
"id": "C0025568",
"name": "metaplasias",
"pos": [
106,
117
]
} |
most proteins in isolated synaptic junctions and nearly all those in postsynaptic densities ( the fibrous protein matrix underlying the postsynaptic membrane at the synapse ) are extensively cross-linked by disulfide bonds into polymers with a molecular weight of 350,000 or greater . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
5,
13
]
} | {
"id": "C0036425",
"name": "fibrous protein",
"pos": [
98,
113
]
} |
effects on the rate of methylation of these neurophysins were investigated with the posterior pituitary hormone ligands , oxytocin and vasopressin , and the hormone-related tripeptide ligand , methionyl-tyrosyl-phenylalaninamide . | NA | {
"id": "C0032017",
"name": "posterior pituitary hormone",
"pos": [
84,
111
]
} | {
"id": "C0030095",
"name": "oxytocin",
"pos": [
122,
130
]
} |
administration of the pyrimidine antimetabolite , 5-fluorouridine , to mice was found to cause a marked specific reduction of the amounts of 5-methyluridine , pseudouridine , and dihydrouridine but not of 3- ( 3-amino-3-carboxypropyl ) uridine in trna from the livers of the treated animals . | NA | {
"id": "C0033846",
"name": "pseudouridine",
"pos": [
159,
172
]
} | {
"id": "C0041984",
"name": "uridine",
"pos": [
236,
243
]
} |
dna repair replication was found decreased in all xeroderma pigmentosum fibroblasts compared with control cells obtained from normal donors . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
72,
83
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
106,
111
]
} |
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